{
  "dbId" : 10222483,
  "stableId" : "R-RNO-442755",
  "displayName" : "Activation of NMDA receptors and postsynaptic events",
  "nodes" : [ {
    "id" : 109508,
    "reactomeId" : 10223693,
    "displayName" : "Glutamate binding, activation of AMPA receptors and synaptic plasticity",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 103,
      "y" : 233
    },
    "minX" : 30,
    "maxX" : 177,
    "minY" : 189,
    "maxY" : 278,
    "prop" : {
      "x" : 30,
      "y" : 189,
      "width" : 147,
      "height" : 89
    },
    "textPosition" : {
      "x" : 34,
      "y" : 198
    },
    "connectors" : [ ]
  }, {
    "id" : 109511,
    "reactomeId" : 10225283,
    "displayName" : "Assembly and cell surface presentation of NMDA receptors",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 658,
      "y" : 367
    },
    "minX" : 566,
    "maxX" : 750,
    "minY" : 322,
    "maxY" : 413,
    "prop" : {
      "x" : 566,
      "y" : 322,
      "width" : 184,
      "height" : 91
    },
    "textPosition" : {
      "x" : 567,
      "y" : 339
    },
    "connectors" : [ ]
  }, {
    "id" : 109510,
    "reactomeId" : 10139403,
    "displayName" : "GRIN1:GRIN2 NMDA receptors:PSD proteins",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 678,
      "y" : 238
    },
    "minX" : 613,
    "maxX" : 750,
    "minY" : 207,
    "maxY" : 263,
    "prop" : {
      "x" : 613,
      "y" : 213,
      "width" : 131,
      "height" : 50
    },
    "textPosition" : {
      "x" : 613,
      "y" : 214
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 744,
          "y" : 213
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 744,
          "y" : 213
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 109521,
    "reactomeId" : 10118107,
    "displayName" : "p21 RAS:GTP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2063,
      "y" : 640
    },
    "minX" : 2020,
    "maxX" : 2113,
    "minY" : 623,
    "maxY" : 651,
    "prop" : {
      "x" : 2020,
      "y" : 629,
      "width" : 87,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2031,
      "y" : 616
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2107,
          "y" : 629
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2107,
          "y" : 629
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 109459,
    "reactomeId" : 74113,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 21,
      "y" : 494
    },
    "minX" : 0,
    "maxX" : 44,
    "minY" : 478,
    "maxY" : 509,
    "prop" : {
      "x" : 0,
      "y" : 479,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 4,
      "y" : 483
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 38,
          "y" : 484
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 38,
          "y" : 484
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109458,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109461,
    "reactomeId" : 10135817,
    "displayName" : "Ca impermeable AMPA receptor ligand complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 220,
      "y" : 332
    },
    "minX" : 166,
    "maxX" : 281,
    "minY" : 301,
    "maxY" : 489,
    "prop" : {
      "x" : 166,
      "y" : 307,
      "width" : 109,
      "height" : 50
    },
    "textPosition" : {
      "x" : 164,
      "y" : 308
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 275,
          "y" : 307
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 275,
          "y" : 307
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109458,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 219,
          "y" : 360
        },
        "to" : {
          "x" : 218,
          "y" : 481
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 218,
          "y" : 485
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 218,
          "y" : 485
        }
      }
    } ]
  }, {
    "id" : 109525,
    "reactomeId" : 10139820,
    "displayName" : "p-T286-CaMKII dodecamer:CALM1:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1337,
      "y" : 650
    },
    "minX" : 1276,
    "maxX" : 1405,
    "minY" : 619,
    "maxY" : 675,
    "prop" : {
      "x" : 1276,
      "y" : 625,
      "width" : 123,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1287,
      "y" : 626
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1399,
          "y" : 625
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1399,
          "y" : 625
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 109460,
    "reactomeId" : 83910,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 436,
      "y" : 521
    },
    "minX" : 415,
    "maxX" : 459,
    "minY" : 505,
    "maxY" : 536,
    "prop" : {
      "x" : 415,
      "y" : 506,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 419,
      "y" : 510
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 453,
          "y" : 511
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 453,
          "y" : 511
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109458,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109462,
    "reactomeId" : 10139834,
    "displayName" : "Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1730,
      "y" : 342
    },
    "minX" : 7,
    "maxX" : 1798,
    "minY" : 0,
    "maxY" : 492,
    "prop" : {
      "x" : 1669,
      "y" : 296,
      "width" : 123,
      "height" : 92
    },
    "textPosition" : {
      "x" : 1674,
      "y" : 297
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1792,
          "y" : 296
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1792,
          "y" : 296
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109458,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1729,
          "y" : 293
        },
        "to" : {
          "x" : 1728,
          "y" : 0
        }
      }, {
        "from" : {
          "x" : 1728,
          "y" : 0
        },
        "to" : {
          "x" : 13,
          "y" : 4
        }
      }, {
        "from" : {
          "x" : 13,
          "y" : 4
        },
        "to" : {
          "x" : 7,
          "y" : 344
        }
      }, {
        "from" : {
          "x" : 7,
          "y" : 344
        },
        "to" : {
          "x" : 211,
          "y" : 492
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 203,
          "y" : 491
        },
        "b" : {
          "x" : 211,
          "y" : 492
        },
        "c" : {
          "x" : 208,
          "y" : 485
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 208,
          "y" : 485
        }
      }
    } ]
  }, {
    "id" : 109465,
    "reactomeId" : 74016,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1282,
      "y" : 397
    },
    "minX" : 1257,
    "maxX" : 1308,
    "minY" : 381,
    "maxY" : 412,
    "prop" : {
      "x" : 1257,
      "y" : 382,
      "width" : 50,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1261,
      "y" : 386
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1302,
          "y" : 387
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1302,
          "y" : 387
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109463,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109464,
    "reactomeId" : 74112,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1276,
      "y" : 174
    },
    "minX" : 1251,
    "maxX" : 1302,
    "minY" : 158,
    "maxY" : 189,
    "prop" : {
      "x" : 1251,
      "y" : 159,
      "width" : 50,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1255,
      "y" : 163
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1296,
          "y" : 164
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1296,
          "y" : 164
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109463,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109467,
    "reactomeId" : 9635195,
    "displayName" : "Ifenprodil",
    "schemaClass" : "ChemicalDrug",
    "renderableClass" : "ChemicalDrug",
    "position" : {
      "x" : 1133,
      "y" : 67
    },
    "minX" : 1093,
    "maxX" : 1283,
    "minY" : 49,
    "maxY" : 270,
    "prop" : {
      "x" : 1093,
      "y" : 49,
      "width" : 81,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1100,
      "y" : 56
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 255,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 109463,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1146,
          "y" : 88
        },
        "to" : {
          "x" : 1280,
          "y" : 268
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1277,
          "y" : 270
        },
        "b" : {
          "x" : 1283,
          "y" : 266
        },
        "c" : {
          "x" : 1280,
          "y" : 268
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1280,
          "y" : 268
        }
      }
    } ]
  }, {
    "id" : 109466,
    "reactomeId" : 10139405,
    "displayName" : "Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1193,
      "y" : 280
    },
    "minX" : 1139,
    "maxX" : 1277,
    "minY" : 249,
    "maxY" : 305,
    "prop" : {
      "x" : 1139,
      "y" : 255,
      "width" : 108,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1142,
      "y" : 242
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1247,
          "y" : 255
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1247,
          "y" : 255
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109463,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1250,
          "y" : 277
        },
        "to" : {
          "x" : 1269,
          "y" : 276
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1273,
          "y" : 276
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1273,
          "y" : 276
        }
      }
    } ]
  }, {
    "id" : 109469,
    "reactomeId" : 10210088,
    "displayName" : "p-S221,T359.S363,S380,T573,T732-RSK",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1323,
      "y" : 1210
    },
    "minX" : 1259,
    "maxX" : 1387,
    "minY" : 1185,
    "maxY" : 1235,
    "prop" : {
      "x" : 1259,
      "y" : 1185,
      "width" : 128,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1259,
      "y" : 1185
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 204
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 109468,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109470,
    "reactomeId" : 10140001,
    "displayName" : "p-S221,T359,S363,S380,T573,T732-RSK",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1096,
      "y" : 859
    },
    "minX" : 736,
    "maxX" : 1160,
    "minY" : 810,
    "maxY" : 884,
    "prop" : {
      "x" : 1032,
      "y" : 834,
      "width" : 128,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1032,
      "y" : 834
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 204
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 109468,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 109471,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1026,
          "y" : 850
        },
        "to" : {
          "x" : 744,
          "y" : 814
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 740,
          "y" : 814
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 740,
          "y" : 814
        }
      }
    } ]
  }, {
    "id" : 109473,
    "reactomeId" : 10124140,
    "displayName" : "Creb1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 637,
      "y" : 927
    },
    "minX" : 614,
    "maxX" : 717,
    "minY" : 863,
    "maxY" : 938,
    "prop" : {
      "x" : 614,
      "y" : 916,
      "width" : 47,
      "height" : 22
    },
    "textPosition" : {
      "x" : 615,
      "y" : 916
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 661,
          "y" : 916
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 661,
          "y" : 916
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109471,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 650,
          "y" : 913
        },
        "to" : {
          "x" : 717,
          "y" : 863
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109472,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 632,
      "y" : 856
    },
    "minX" : 612,
    "maxX" : 717,
    "minY" : 840,
    "maxY" : 871,
    "prop" : {
      "x" : 612,
      "y" : 841,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 616,
      "y" : 845
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 647,
          "y" : 846
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 647,
          "y" : 846
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109471,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 655,
          "y" : 857
        },
        "to" : {
          "x" : 717,
          "y" : 863
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109475,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 648,
      "y" : 726
    },
    "minX" : 628,
    "maxX" : 737,
    "minY" : 710,
    "maxY" : 741,
    "prop" : {
      "x" : 628,
      "y" : 711,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 632,
      "y" : 715
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 664,
          "y" : 716
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 664,
          "y" : 716
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109471,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 672,
          "y" : 728
        },
        "to" : {
          "x" : 737,
          "y" : 737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 679,
          "y" : 725
        },
        "b" : {
          "x" : 672,
          "y" : 728
        },
        "c" : {
          "x" : 678,
          "y" : 733
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 678,
          "y" : 733
        }
      }
    } ]
  }, {
    "id" : 109474,
    "reactomeId" : 10124143,
    "displayName" : "phospho-Creb1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 654,
      "y" : 637
    },
    "minX" : 605,
    "maxX" : 737,
    "minY" : 620,
    "maxY" : 737,
    "prop" : {
      "x" : 605,
      "y" : 626,
      "width" : 99,
      "height" : 22
    },
    "textPosition" : {
      "x" : 621,
      "y" : 620
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 704,
          "y" : 626
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 704,
          "y" : 626
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109471,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 663,
          "y" : 651
        },
        "to" : {
          "x" : 737,
          "y" : 737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 671,
          "y" : 654
        },
        "b" : {
          "x" : 663,
          "y" : 651
        },
        "c" : {
          "x" : 664,
          "y" : 659
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 664,
          "y" : 659
        }
      }
    } ]
  }, {
    "id" : 109477,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 555,
      "y" : 1029
    },
    "minX" : 535,
    "maxX" : 604,
    "minY" : 1013,
    "maxY" : 1044,
    "prop" : {
      "x" : 535,
      "y" : 1014,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 539,
      "y" : 1018
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 570,
          "y" : 1019
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 570,
          "y" : 1019
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109476,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 578,
          "y" : 1030
        },
        "to" : {
          "x" : 604,
          "y" : 1032
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109479,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 560,
      "y" : 1082
    },
    "minX" : 540,
    "maxX" : 607,
    "minY" : 1066,
    "maxY" : 1097,
    "prop" : {
      "x" : 540,
      "y" : 1067,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 544,
      "y" : 1071
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 576,
          "y" : 1072
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 576,
          "y" : 1072
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109476,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 584,
          "y" : 1080
        },
        "to" : {
          "x" : 607,
          "y" : 1078
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 591,
          "y" : 1075
        },
        "b" : {
          "x" : 584,
          "y" : 1080
        },
        "c" : {
          "x" : 591,
          "y" : 1083
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 591,
          "y" : 1083
        }
      }
    } ]
  }, {
    "id" : 109478,
    "reactomeId" : 10140017,
    "displayName" : "CaMKK:CALM1:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 608,
      "y" : 990
    },
    "minX" : 559,
    "maxX" : 663,
    "minY" : 966,
    "maxY" : 1053,
    "prop" : {
      "x" : 559,
      "y" : 972,
      "width" : 98,
      "height" : 36
    },
    "textPosition" : {
      "x" : 560,
      "y" : 973
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 657,
          "y" : 972
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 657,
          "y" : 972
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109476,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 606,
          "y" : 1011
        },
        "to" : {
          "x" : 604,
          "y" : 1032
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 109476,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 618,
          "y" : 1011
        },
        "to" : {
          "x" : 638,
          "y" : 1042
        }
      }, {
        "from" : {
          "x" : 638,
          "y" : 1042
        },
        "to" : {
          "x" : 618,
          "y" : 1048
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 614,
          "y" : 1049
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 614,
          "y" : 1049
        }
      }
    } ]
  }, {
    "id" : 109480,
    "reactomeId" : 10140023,
    "displayName" : "p-CaMKK:CALM1:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 611,
      "y" : 1131
    },
    "minX" : 555,
    "maxX" : 674,
    "minY" : 1078,
    "maxY" : 1149,
    "prop" : {
      "x" : 555,
      "y" : 1113,
      "width" : 113,
      "height" : 36
    },
    "textPosition" : {
      "x" : 557,
      "y" : 1114
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 668,
          "y" : 1113
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 668,
          "y" : 1113
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109476,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 609,
          "y" : 1110
        },
        "to" : {
          "x" : 607,
          "y" : 1078
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 605,
          "y" : 1103
        },
        "b" : {
          "x" : 609,
          "y" : 1110
        },
        "c" : {
          "x" : 613,
          "y" : 1103
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 613,
          "y" : 1103
        }
      }
    } ]
  }, {
    "id" : 109483,
    "reactomeId" : 10112040,
    "displayName" : "p-T200-CAMK4:CALM1:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 459,
      "y" : 1070
    },
    "minX" : 405,
    "maxX" : 520,
    "minY" : 973,
    "maxY" : 1088,
    "prop" : {
      "x" : 405,
      "y" : 1052,
      "width" : 109,
      "height" : 36
    },
    "textPosition" : {
      "x" : 409,
      "y" : 1053
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 514,
          "y" : 1052
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 514,
          "y" : 1052
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109481,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 459,
          "y" : 1049
        },
        "to" : {
          "x" : 462,
          "y" : 1007
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 109481,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 470,
          "y" : 1049
        },
        "to" : {
          "x" : 487,
          "y" : 1025
        }
      }, {
        "from" : {
          "x" : 487,
          "y" : 1025
        },
        "to" : {
          "x" : 470,
          "y" : 981
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 468,
          "y" : 977
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 468,
          "y" : 977
        }
      }
    } ]
  }, {
    "id" : 109482,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 426,
      "y" : 998
    },
    "minX" : 406,
    "maxX" : 462,
    "minY" : 982,
    "maxY" : 1013,
    "prop" : {
      "x" : 406,
      "y" : 983,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 410,
      "y" : 987
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 441,
          "y" : 988
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 441,
          "y" : 988
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109481,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 449,
          "y" : 1003
        },
        "to" : {
          "x" : 462,
          "y" : 1007
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109485,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 421,
      "y" : 924
    },
    "minX" : 401,
    "maxX" : 467,
    "minY" : 908,
    "maxY" : 939,
    "prop" : {
      "x" : 401,
      "y" : 909,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 405,
      "y" : 913
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 437,
          "y" : 914
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 437,
          "y" : 914
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109481,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 445,
          "y" : 925
        },
        "to" : {
          "x" : 467,
          "y" : 928
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 452,
          "y" : 922
        },
        "b" : {
          "x" : 445,
          "y" : 925
        },
        "c" : {
          "x" : 451,
          "y" : 930
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 451,
          "y" : 930
        }
      }
    } ]
  }, {
    "id" : 109484,
    "reactomeId" : 10112046,
    "displayName" : "p-S12.S13,T200-CAMK4:CALM1:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 467,
      "y" : 864
    },
    "minX" : 410,
    "maxX" : 531,
    "minY" : 833,
    "maxY" : 928,
    "prop" : {
      "x" : 410,
      "y" : 839,
      "width" : 115,
      "height" : 50
    },
    "textPosition" : {
      "x" : 412,
      "y" : 840
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 525,
          "y" : 839
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 525,
          "y" : 839
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109481,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 467,
          "y" : 892
        },
        "to" : {
          "x" : 467,
          "y" : 928
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 471,
          "y" : 899
        },
        "b" : {
          "x" : 467,
          "y" : 892
        },
        "c" : {
          "x" : 463,
          "y" : 899
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 463,
          "y" : 899
        }
      }
    } ]
  }, {
    "id" : 109487,
    "reactomeId" : 10112083,
    "displayName" : "PKA tetramer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1017,
      "y" : 483
    },
    "minX" : 947,
    "maxX" : 1066,
    "minY" : 466,
    "maxY" : 494,
    "prop" : {
      "x" : 974,
      "y" : 472,
      "width" : 86,
      "height" : 22
    },
    "textPosition" : {
      "x" : 985,
      "y" : 459
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1060,
          "y" : 472
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1060,
          "y" : 472
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109486,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 971,
          "y" : 485
        },
        "to" : {
          "x" : 947,
          "y" : 487
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109489,
    "reactomeId" : 10112085,
    "displayName" : "PKA tetramer:4xcAMP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 934,
      "y" : 557
    },
    "minX" : 868,
    "maxX" : 985,
    "minY" : 533,
    "maxY" : 575,
    "prop" : {
      "x" : 889,
      "y" : 539,
      "width" : 90,
      "height" : 36
    },
    "textPosition" : {
      "x" : 900,
      "y" : 526
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 979,
          "y" : 539
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 979,
          "y" : 539
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109490,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 109490,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 886,
          "y" : 544
        },
        "to" : {
          "x" : 875,
          "y" : 541
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 872,
          "y" : 540
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 872,
          "y" : 540
        }
      }
    }, {
      "edgeId" : 109486,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109488,
    "reactomeId" : 30389,
    "displayName" : "cAMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 899,
      "y" : 451
    },
    "minX" : 875,
    "maxX" : 947,
    "minY" : 435,
    "maxY" : 487,
    "prop" : {
      "x" : 875,
      "y" : 436,
      "width" : 48,
      "height" : 30
    },
    "textPosition" : {
      "x" : 878,
      "y" : 440
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 918,
          "y" : 441
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 918,
          "y" : 441
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109486,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 919,
          "y" : 469
        },
        "to" : {
          "x" : 947,
          "y" : 487
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 927,
            "y" : 472
          },
          "b" : {
            "x" : 939,
            "y" : 484
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 933,
            "y" : 478
          }
        }
      }
    } ]
  }, {
    "id" : 109491,
    "reactomeId" : 10112081,
    "displayName" : "PKA catalytic subunit",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 731,
      "y" : 557
    },
    "minX" : 667,
    "maxX" : 837,
    "minY" : 532,
    "maxY" : 568,
    "prop" : {
      "x" : 667,
      "y" : 546,
      "width" : 128,
      "height" : 22
    },
    "textPosition" : {
      "x" : 685,
      "y" : 540
    },
    "connectors" : [ {
      "edgeId" : 109490,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 789,
          "y" : 540
        },
        "to" : {
          "x" : 837,
          "y" : 537
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 807,
            "y" : 532
          },
          "b" : {
            "x" : 819,
            "y" : 544
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 813,
            "y" : 538
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 796,
          "y" : 536
        },
        "b" : {
          "x" : 789,
          "y" : 540
        },
        "c" : {
          "x" : 796,
          "y" : 544
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 796,
          "y" : 544
        }
      }
    } ]
  }, {
    "id" : 109492,
    "reactomeId" : 10112087,
    "displayName" : "cAMP:PKA regulatory subunit",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 801,
      "y" : 490
    },
    "minX" : 735,
    "maxX" : 874,
    "minY" : 466,
    "maxY" : 537,
    "prop" : {
      "x" : 735,
      "y" : 472,
      "width" : 133,
      "height" : 36
    },
    "textPosition" : {
      "x" : 740,
      "y" : 473
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 868,
          "y" : 472
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 868,
          "y" : 472
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109490,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 814,
          "y" : 511
        },
        "to" : {
          "x" : 837,
          "y" : 537
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 822,
          "y" : 514
        },
        "b" : {
          "x" : 814,
          "y" : 511
        },
        "c" : {
          "x" : 816,
          "y" : 519
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 816,
          "y" : 519
        }
      }
    } ]
  }, {
    "id" : 109495,
    "reactomeId" : 10211052,
    "displayName" : "CaMKK:CALM1:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1760,
      "y" : 729
    },
    "minX" : 1711,
    "maxX" : 1815,
    "minY" : 705,
    "maxY" : 802,
    "prop" : {
      "x" : 1711,
      "y" : 711,
      "width" : 98,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1712,
      "y" : 712
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1809,
          "y" : 711
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1809,
          "y" : 711
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109493,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1758,
          "y" : 750
        },
        "to" : {
          "x" : 1755,
          "y" : 776
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 109493,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1741,
          "y" : 750
        },
        "to" : {
          "x" : 1720,
          "y" : 767
        }
      }, {
        "from" : {
          "x" : 1720,
          "y" : 767
        },
        "to" : {
          "x" : 1741,
          "y" : 795
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1743,
          "y" : 798
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1743,
          "y" : 798
        }
      }
    } ]
  }, {
    "id" : 109558,
    "reactomeId" : 10224791,
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 2063,
      "y" : 754
    },
    "minX" : 2006,
    "maxX" : 2121,
    "minY" : 732,
    "maxY" : 776,
    "prop" : {
      "x" : 2006,
      "y" : 732,
      "width" : 115,
      "height" : 44
    },
    "textPosition" : {
      "x" : 2005,
      "y" : 732
    },
    "connectors" : [ ]
  }, {
    "id" : 109494,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1816,
      "y" : 779
    },
    "minX" : 1755,
    "maxX" : 1837,
    "minY" : 763,
    "maxY" : 794,
    "prop" : {
      "x" : 1796,
      "y" : 764,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1800,
      "y" : 768
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1831,
          "y" : 769
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1831,
          "y" : 769
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109493,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1793,
          "y" : 778
        },
        "to" : {
          "x" : 1755,
          "y" : 776
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109497,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1819,
      "y" : 841
    },
    "minX" : 1754,
    "maxX" : 1841,
    "minY" : 825,
    "maxY" : 856,
    "prop" : {
      "x" : 1799,
      "y" : 826,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1803,
      "y" : 830
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1835,
          "y" : 831
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1835,
          "y" : 831
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109493,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1796,
          "y" : 841
        },
        "to" : {
          "x" : 1754,
          "y" : 842
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1789,
          "y" : 845
        },
        "b" : {
          "x" : 1796,
          "y" : 841
        },
        "c" : {
          "x" : 1789,
          "y" : 837
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1789,
          "y" : 837
        }
      }
    } ]
  }, {
    "id" : 109560,
    "reactomeId" : 10118219,
    "displayName" : "p-T,Y MAPK dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 805,
      "y" : 1565
    },
    "minX" : 743,
    "maxX" : 867,
    "minY" : 1554,
    "maxY" : 1576,
    "prop" : {
      "x" : 743,
      "y" : 1554,
      "width" : 124,
      "height" : 22
    },
    "textPosition" : {
      "x" : 744,
      "y" : 1554
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ ]
  }, {
    "id" : 109496,
    "reactomeId" : 10211060,
    "displayName" : "p-CaMKK:CALM1:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1762,
      "y" : 901
    },
    "minX" : 1706,
    "maxX" : 1825,
    "minY" : 842,
    "maxY" : 919,
    "prop" : {
      "x" : 1706,
      "y" : 883,
      "width" : 113,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1708,
      "y" : 884
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1819,
          "y" : 883
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1819,
          "y" : 883
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109493,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1759,
          "y" : 880
        },
        "to" : {
          "x" : 1754,
          "y" : 842
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1754,
          "y" : 874
        },
        "b" : {
          "x" : 1759,
          "y" : 880
        },
        "c" : {
          "x" : 1762,
          "y" : 873
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1762,
          "y" : 873
        }
      }
    } ]
  }, {
    "id" : 109499,
    "reactomeId" : 10211069,
    "displayName" : "CAMK1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1623,
      "y" : 867
    },
    "minX" : 1598,
    "maxX" : 1681,
    "minY" : 850,
    "maxY" : 882,
    "prop" : {
      "x" : 1598,
      "y" : 856,
      "width" : 51,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1599,
      "y" : 856
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1649,
          "y" : 856
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1649,
          "y" : 856
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109498,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1652,
          "y" : 873
        },
        "to" : {
          "x" : 1681,
          "y" : 882
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109501,
    "reactomeId" : 10211071,
    "displayName" : "CAMK1:CALM1:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1685,
      "y" : 1002
    },
    "minX" : 1636,
    "maxX" : 1741,
    "minY" : 978,
    "maxY" : 1020,
    "prop" : {
      "x" : 1636,
      "y" : 984,
      "width" : 99,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1637,
      "y" : 985
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1735,
          "y" : 984
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1735,
          "y" : 984
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109498,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 109500,
    "reactomeId" : 10112128,
    "displayName" : "CALM1:4xCa2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1542,
      "y" : 576
    },
    "minX" : 1492,
    "maxX" : 1681,
    "minY" : 559,
    "maxY" : 882,
    "prop" : {
      "x" : 1492,
      "y" : 565,
      "width" : 101,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1492,
      "y" : 566
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1593,
          "y" : 565
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1593,
          "y" : 565
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 109498,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1552,
          "y" : 590
        },
        "to" : {
          "x" : 1651,
          "y" : 687
        }
      }, {
        "from" : {
          "x" : 1651,
          "y" : 687
        },
        "to" : {
          "x" : 1681,
          "y" : 882
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 109490,
    "reactomeId" : 10112090,
    "displayName" : "cAMP induces dissociation of inactive PKA tetramers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 860,
      "y" : 537
    },
    "minX" : 837,
    "maxX" : 886,
    "minY" : 531,
    "maxY" : 543,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 886,
        "y" : 539
      },
      "to" : {
        "x" : 860,
        "y" : 537
      }
    }, {
      "from" : {
        "x" : 860,
        "y" : 537
      },
      "to" : {
        "x" : 837,
        "y" : 537
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 854,
        "y" : 531
      },
      "b" : {
        "x" : 866,
        "y" : 543
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 860,
        "y" : 537
      }
    },
    "inputs" : [ {
      "id" : 109489
    } ],
    "outputs" : [ {
      "id" : 109491,
      "points" : [ {
        "x" : 789,
        "y" : 540
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 109492,
      "points" : [ {
        "x" : 814,
        "y" : 511
      } ]
    } ],
    "catalysts" : [ {
      "id" : 109489,
      "points" : [ {
        "x" : 886,
        "y" : 544
      } ]
    } ]
  }, {
    "id" : 109458,
    "reactomeId" : 10139836,
    "displayName" : "Membrane depolarization upon activation of Ca impermeable AMPA receptors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 218,
      "y" : 497
    },
    "minX" : 46,
    "maxX" : 412,
    "minY" : 491,
    "maxY" : 518,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 46,
        "y" : 494
      },
      "to" : {
        "x" : 218,
        "y" : 497
      }
    }, {
      "from" : {
        "x" : 218,
        "y" : 497
      },
      "to" : {
        "x" : 412,
        "y" : 518
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 405,
        "y" : 521
      },
      "b" : {
        "x" : 412,
        "y" : 518
      },
      "c" : {
        "x" : 406,
        "y" : 513
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 406,
        "y" : 513
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 212,
        "y" : 491
      },
      "b" : {
        "x" : 224,
        "y" : 503
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 218,
        "y" : 497
      }
    },
    "inputs" : [ {
      "id" : 109459
    } ],
    "outputs" : [ {
      "id" : 109460
    } ],
    "catalysts" : [ {
      "id" : 109461,
      "points" : [ {
        "x" : 219,
        "y" : 360
      } ]
    } ],
    "activators" : [ {
      "id" : 109462,
      "points" : [ {
        "x" : 1729,
        "y" : 293
      }, {
        "x" : 1728,
        "y" : 0
      }, {
        "x" : 13,
        "y" : 4
      }, {
        "x" : 7,
        "y" : 344
      } ]
    } ]
  }, {
    "id" : 109493,
    "reactomeId" : 10211063,
    "displayName" : "CaMKK autophosphorylates in the cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1750,
      "y" : 808
    },
    "minX" : 1744,
    "maxX" : 1756,
    "minY" : 776,
    "maxY" : 842,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1755,
        "y" : 776
      },
      "to" : {
        "x" : 1750,
        "y" : 808
      }
    }, {
      "from" : {
        "x" : 1750,
        "y" : 808
      },
      "to" : {
        "x" : 1754,
        "y" : 842
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1744,
        "y" : 802
      },
      "b" : {
        "x" : 1756,
        "y" : 814
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1750,
        "y" : 808
      }
    },
    "inputs" : [ {
      "id" : 109494,
      "points" : [ {
        "x" : 1793,
        "y" : 778
      } ]
    }, {
      "id" : 109495,
      "points" : [ {
        "x" : 1758,
        "y" : 750
      } ]
    } ],
    "outputs" : [ {
      "id" : 109496,
      "points" : [ {
        "x" : 1759,
        "y" : 880
      } ]
    }, {
      "id" : 109497,
      "points" : [ {
        "x" : 1796,
        "y" : 841
      } ]
    } ],
    "catalysts" : [ {
      "id" : 109495,
      "points" : [ {
        "x" : 1741,
        "y" : 750
      }, {
        "x" : 1720,
        "y" : 767
      } ]
    } ]
  }, {
    "id" : 109476,
    "reactomeId" : 10140026,
    "displayName" : "CaMKK autophosphorylates in the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 603,
      "y" : 1053
    },
    "minX" : 597,
    "maxX" : 609,
    "minY" : 1032,
    "maxY" : 1078,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 604,
        "y" : 1032
      },
      "to" : {
        "x" : 603,
        "y" : 1053
      }
    }, {
      "from" : {
        "x" : 603,
        "y" : 1053
      },
      "to" : {
        "x" : 607,
        "y" : 1078
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 597,
        "y" : 1047
      },
      "b" : {
        "x" : 609,
        "y" : 1059
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 603,
        "y" : 1053
      }
    },
    "inputs" : [ {
      "id" : 109477,
      "points" : [ {
        "x" : 578,
        "y" : 1030
      } ]
    }, {
      "id" : 109478,
      "points" : [ {
        "x" : 606,
        "y" : 1011
      } ]
    } ],
    "outputs" : [ {
      "id" : 109479,
      "points" : [ {
        "x" : 584,
        "y" : 1080
      } ]
    }, {
      "id" : 109480,
      "points" : [ {
        "x" : 609,
        "y" : 1110
      } ]
    } ],
    "catalysts" : [ {
      "id" : 109478,
      "points" : [ {
        "x" : 618,
        "y" : 1011
      }, {
        "x" : 638,
        "y" : 1042
      } ]
    } ]
  }, {
    "id" : 109463,
    "reactomeId" : 10139408,
    "displayName" : "Ca2+ influx into the post-synaptic cell",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1285,
      "y" : 275
    },
    "minX" : 1277,
    "maxX" : 1291,
    "minY" : 192,
    "maxY" : 379,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1277,
        "y" : 192
      },
      "to" : {
        "x" : 1285,
        "y" : 275
      }
    }, {
      "from" : {
        "x" : 1285,
        "y" : 275
      },
      "to" : {
        "x" : 1282,
        "y" : 379
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1278,
        "y" : 372
      },
      "b" : {
        "x" : 1282,
        "y" : 379
      },
      "c" : {
        "x" : 1286,
        "y" : 372
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1286,
        "y" : 372
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1279,
        "y" : 269
      },
      "b" : {
        "x" : 1291,
        "y" : 281
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1285,
        "y" : 275
      }
    },
    "inputs" : [ {
      "id" : 109464
    } ],
    "outputs" : [ {
      "id" : 109465
    } ],
    "catalysts" : [ {
      "id" : 109466,
      "points" : [ {
        "x" : 1250,
        "y" : 277
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 109467,
      "points" : [ {
        "x" : 1146,
        "y" : 88
      } ]
    } ]
  }, {
    "id" : 109481,
    "reactomeId" : 10112049,
    "displayName" : "CAMK4 autophosphorylates",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 464,
      "y" : 966
    },
    "minX" : 458,
    "maxX" : 470,
    "minY" : 928,
    "maxY" : 1007,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 462,
        "y" : 1007
      },
      "to" : {
        "x" : 464,
        "y" : 966
      }
    }, {
      "from" : {
        "x" : 464,
        "y" : 966
      },
      "to" : {
        "x" : 467,
        "y" : 928
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 458,
        "y" : 960
      },
      "b" : {
        "x" : 470,
        "y" : 972
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 464,
        "y" : 966
      }
    },
    "inputs" : [ {
      "id" : 109482,
      "points" : [ {
        "x" : 449,
        "y" : 1003
      } ]
    }, {
      "id" : 109483,
      "points" : [ {
        "x" : 459,
        "y" : 1049
      } ]
    } ],
    "outputs" : [ {
      "id" : 109484,
      "points" : [ {
        "x" : 467,
        "y" : 892
      } ]
    }, {
      "id" : 109485,
      "points" : [ {
        "x" : 445,
        "y" : 925
      } ]
    } ],
    "catalysts" : [ {
      "id" : 109483,
      "points" : [ {
        "x" : 470,
        "y" : 1049
      }, {
        "x" : 487,
        "y" : 1025
      } ]
    } ]
  }, {
    "id" : 109498,
    "reactomeId" : 10211073,
    "displayName" : "CAMK1 binds calmodulin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1683,
      "y" : 928
    },
    "minX" : 1677,
    "maxX" : 1689,
    "minY" : 882,
    "maxY" : 981,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1681,
        "y" : 882
      },
      "to" : {
        "x" : 1683,
        "y" : 928
      }
    }, {
      "from" : {
        "x" : 1683,
        "y" : 928
      },
      "to" : {
        "x" : 1684,
        "y" : 981
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1680,
        "y" : 974
      },
      "b" : {
        "x" : 1684,
        "y" : 981
      },
      "c" : {
        "x" : 1688,
        "y" : 974
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1688,
        "y" : 974
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1683,
        "y" : 928
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1683,
        "y" : 928
      }
    },
    "inputs" : [ {
      "id" : 109499,
      "points" : [ {
        "x" : 1652,
        "y" : 873
      } ]
    }, {
      "id" : 109500,
      "points" : [ {
        "x" : 1552,
        "y" : 590
      }, {
        "x" : 1651,
        "y" : 687
      } ]
    } ],
    "outputs" : [ {
      "id" : 109501
    } ]
  }, {
    "id" : 109468,
    "reactomeId" : 10210090,
    "displayName" : "p-S363,S380,T573 RS6K translocates to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1231,
      "y" : 888
    },
    "minX" : 1166,
    "maxX" : 1407,
    "minY" : 872,
    "maxY" : 1179,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1334,
        "y" : 1179
      },
      "to" : {
        "x" : 1405,
        "y" : 1034
      }
    }, {
      "from" : {
        "x" : 1405,
        "y" : 1034
      },
      "to" : {
        "x" : 1407,
        "y" : 945
      }
    }, {
      "from" : {
        "x" : 1407,
        "y" : 945
      },
      "to" : {
        "x" : 1231,
        "y" : 888
      }
    }, {
      "from" : {
        "x" : 1231,
        "y" : 888
      },
      "to" : {
        "x" : 1166,
        "y" : 872
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1174,
        "y" : 870
      },
      "b" : {
        "x" : 1166,
        "y" : 872
      },
      "c" : {
        "x" : 1172,
        "y" : 878
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1172,
        "y" : 878
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1225,
        "y" : 882
      },
      "b" : {
        "x" : 1237,
        "y" : 894
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1231,
        "y" : 888
      }
    },
    "inputs" : [ {
      "id" : 109469
    } ],
    "outputs" : [ {
      "id" : 109470
    } ]
  }, {
    "id" : 109471,
    "reactomeId" : 10140004,
    "displayName" : "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 728,
      "y" : 812
    },
    "minX" : 717,
    "maxX" : 737,
    "minY" : 737,
    "maxY" : 863,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 717,
        "y" : 863
      },
      "to" : {
        "x" : 728,
        "y" : 812
      }
    }, {
      "from" : {
        "x" : 728,
        "y" : 812
      },
      "to" : {
        "x" : 737,
        "y" : 737
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 722,
        "y" : 806
      },
      "b" : {
        "x" : 734,
        "y" : 818
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 728,
        "y" : 812
      }
    },
    "inputs" : [ {
      "id" : 109472,
      "points" : [ {
        "x" : 655,
        "y" : 857
      } ]
    }, {
      "id" : 109473,
      "points" : [ {
        "x" : 650,
        "y" : 913
      } ]
    } ],
    "outputs" : [ {
      "id" : 109474,
      "points" : [ {
        "x" : 663,
        "y" : 651
      } ]
    }, {
      "id" : 109475,
      "points" : [ {
        "x" : 672,
        "y" : 728
      } ]
    } ],
    "catalysts" : [ {
      "id" : 109470,
      "points" : [ {
        "x" : 1026,
        "y" : 850
      } ]
    } ]
  }, {
    "id" : 109486,
    "reactomeId" : 10205622,
    "displayName" : "cAMP binds PKA tetramer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 958,
      "y" : 512
    },
    "minX" : 943,
    "maxX" : 964,
    "minY" : 487,
    "maxY" : 536,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 947,
        "y" : 487
      },
      "to" : {
        "x" : 958,
        "y" : 512
      }
    }, {
      "from" : {
        "x" : 958,
        "y" : 512
      },
      "to" : {
        "x" : 943,
        "y" : 536
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 943,
        "y" : 528
      },
      "b" : {
        "x" : 943,
        "y" : 536
      },
      "c" : {
        "x" : 950,
        "y" : 532
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 950,
        "y" : 532
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 958,
        "y" : 512
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 958,
        "y" : 512
      }
    },
    "inputs" : [ {
      "id" : 109487,
      "points" : [ {
        "x" : 971,
        "y" : 485
      } ]
    }, {
      "id" : 109488,
      "points" : [ {
        "x" : 919,
        "y" : 469
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 109489
    } ]
  } ],
  "compartments" : [ {
    "id" : 109506,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 798,
      "y" : 949
    },
    "minX" : 365,
    "maxX" : 1232,
    "minY" : 591,
    "maxY" : 1308,
    "prop" : {
      "x" : 365,
      "y" : 591,
      "width" : 867,
      "height" : 717
    },
    "textPosition" : {
      "x" : 377,
      "y" : 1257
    },
    "insets" : {
      "x" : 375,
      "y" : 601,
      "width" : 847,
      "height" : 697
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 109471, 109472, 109473, 109474, 109475, 109481, 109484, 109522, 109571, 109478, 109476, 109480, 109483, 109482, 109485, 109477, 109479, 109468, 109470 ]
  }, {
    "id" : 109502,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1231,
      "y" : 866
    },
    "minX" : 70,
    "maxX" : 2393,
    "minY" : 106,
    "maxY" : 1627,
    "prop" : {
      "x" : 70,
      "y" : 106,
      "width" : 2323,
      "height" : 1521
    },
    "textPosition" : {
      "x" : 148,
      "y" : 1558
    },
    "insets" : {
      "x" : 80,
      "y" : 116,
      "width" : 2303,
      "height" : 1501
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 109458, 109460, 109461, 109463, 109465, 109506, 109488, 109500, 109508, 109569, 109510, 109466, 109511, 109570, 109521, 109487, 109489, 109486, 109490, 109491, 109492, 109525, 109462, 109495, 109496, 109493, 109494, 109497, 109498, 109499, 109501, 109558, 109572, 109573, 109560, 109469, 109464 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 109569,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 172,
      "y" : 292
    },
    "minX" : 156,
    "maxX" : 188,
    "minY" : 281,
    "maxY" : 304,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 156,
        "y" : 281
      },
      "to" : {
        "x" : 188,
        "y" : 304
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 180,
        "y" : 303
      },
      "b" : {
        "x" : 188,
        "y" : 304
      },
      "c" : {
        "x" : 185,
        "y" : 297
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 185,
        "y" : 297
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 166,
        "y" : 286
      },
      "b" : {
        "x" : 178,
        "y" : 298
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 172,
        "y" : 292
      }
    },
    "inputs" : [ {
      "id" : 109508
    } ],
    "outputs" : [ {
      "id" : 109461
    } ]
  }, {
    "id" : 109570,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 668,
      "y" : 292
    },
    "minX" : 662,
    "maxX" : 674,
    "minY" : 266,
    "maxY" : 319,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 664,
        "y" : 319
      },
      "to" : {
        "x" : 673,
        "y" : 266
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 676,
        "y" : 274
      },
      "b" : {
        "x" : 673,
        "y" : 266
      },
      "c" : {
        "x" : 668,
        "y" : 272
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 668,
        "y" : 272
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 662,
        "y" : 286
      },
      "b" : {
        "x" : 674,
        "y" : 298
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 668,
        "y" : 292
      }
    },
    "inputs" : [ {
      "id" : 109511
    } ],
    "outputs" : [ {
      "id" : 109510
    } ]
  }, {
    "id" : 109573,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1706,
      "y" : 526
    },
    "minX" : 1374,
    "maxX" : 2047,
    "minY" : 520,
    "maxY" : 729,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1374,
        "y" : 622
      },
      "to" : {
        "x" : 1516,
        "y" : 530
      }
    }, {
      "from" : {
        "x" : 1516,
        "y" : 530
      },
      "to" : {
        "x" : 1896,
        "y" : 523
      }
    }, {
      "from" : {
        "x" : 1896,
        "y" : 523
      },
      "to" : {
        "x" : 2047,
        "y" : 729
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2040,
        "y" : 726
      },
      "b" : {
        "x" : 2047,
        "y" : 729
      },
      "c" : {
        "x" : 2046,
        "y" : 721
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2046,
        "y" : 721
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1700,
        "y" : 520
      },
      "b" : {
        "x" : 1712,
        "y" : 532
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1706,
        "y" : 526
      }
    },
    "inputs" : [ {
      "id" : 109525
    } ],
    "outputs" : [ {
      "id" : 109558
    } ]
  }, {
    "id" : 109572,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2063,
      "y" : 691
    },
    "minX" : 2057,
    "maxX" : 2069,
    "minY" : 654,
    "maxY" : 729,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2063,
        "y" : 654
      },
      "to" : {
        "x" : 2063,
        "y" : 729
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2059,
        "y" : 722
      },
      "b" : {
        "x" : 2063,
        "y" : 729
      },
      "c" : {
        "x" : 2067,
        "y" : 722
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2067,
        "y" : 722
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2057,
        "y" : 685
      },
      "b" : {
        "x" : 2069,
        "y" : 697
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2063,
        "y" : 691
      }
    },
    "inputs" : [ {
      "id" : 109521
    } ],
    "outputs" : [ {
      "id" : 109558
    } ]
  }, {
    "id" : 109574,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1431,
      "y" : 1668
    },
    "minX" : 804,
    "maxX" : 2062,
    "minY" : 779,
    "maxY" : 1674,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2062,
        "y" : 779
      },
      "to" : {
        "x" : 2058,
        "y" : 1670
      }
    }, {
      "from" : {
        "x" : 2058,
        "y" : 1670
      },
      "to" : {
        "x" : 804,
        "y" : 1666
      }
    }, {
      "from" : {
        "x" : 804,
        "y" : 1666
      },
      "to" : {
        "x" : 804,
        "y" : 1582
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 808,
        "y" : 1589
      },
      "b" : {
        "x" : 804,
        "y" : 1582
      },
      "c" : {
        "x" : 800,
        "y" : 1589
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 800,
        "y" : 1589
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1425,
        "y" : 1662
      },
      "b" : {
        "x" : 1437,
        "y" : 1674
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1431,
        "y" : 1668
      }
    },
    "inputs" : [ {
      "id" : 109558
    } ],
    "outputs" : [ {
      "id" : 109560
    } ]
  } ],
  "shadows" : [ {
    "id" : 109575,
    "reactomeId" : 10222481,
    "displayName" : "Post NMDA receptor activation events",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1120,
      "y" : 835
    },
    "minX" : 391,
    "maxX" : 1850,
    "minY" : 426,
    "maxY" : 1245,
    "prop" : {
      "x" : 391,
      "y" : 546,
      "width" : 1459,
      "height" : 699
    },
    "points" : [ {
      "x" : 391,
      "y" : 426
    }, {
      "x" : 1850,
      "y" : 426
    }, {
      "x" : 1850,
      "y" : 1245
    }, {
      "x" : 391,
      "y" : 1245
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 109576,
    "reactomeId" : 10223823,
    "displayName" : "Unblocking of NMDA receptors, glutamate binding and activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 896,
      "y" : 292
    },
    "minX" : -10,
    "maxX" : 1802,
    "minY" : 39,
    "maxY" : 546,
    "prop" : {
      "x" : -10,
      "y" : 39,
      "width" : 1812,
      "height" : 387
    },
    "points" : [ {
      "x" : -10,
      "y" : 39
    }, {
      "x" : 1802,
      "y" : 39
    }, {
      "x" : 1802,
      "y" : 546
    }, {
      "x" : -10,
      "y" : 546
    } ],
    "colour" : "#dc3912"
  } ],
  "minX" : 0,
  "maxX" : 2393,
  "minY" : 0,
  "maxY" : 1674,
  "disease" : false
}