{
  "dbId" : 10224539,
  "stableId" : "R-RNO-3238698",
  "displayName" : "WNT ligand biogenesis and trafficking",
  "nodes" : [ {
    "id" : 68448,
    "reactomeId" : 10169959,
    "displayName" : "WLS:WNT",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 739,
      "y" : 416
    },
    "minX" : 693,
    "maxX" : 792,
    "minY" : 398,
    "maxY" : 429,
    "prop" : {
      "x" : 693,
      "y" : 404,
      "width" : 93,
      "height" : 25
    },
    "textPosition" : {
      "x" : 707,
      "y" : 408
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 786,
          "y" : 404
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 786,
          "y" : 404
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 68449,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 68446,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 68450,
    "reactomeId" : 10170001,
    "displayName" : "WLS:WNT",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 843,
      "y" : 171
    },
    "minX" : 811,
    "maxX" : 881,
    "minY" : 154,
    "maxY" : 182,
    "prop" : {
      "x" : 811,
      "y" : 160,
      "width" : 64,
      "height" : 22
    },
    "textPosition" : {
      "x" : 811,
      "y" : 161
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 875,
          "y" : 160
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 875,
          "y" : 160
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 68449,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 68451,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 68463,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 68453,
    "reactomeId" : 10170031,
    "displayName" : "WNTs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 689,
      "y" : 76
    },
    "minX" : 665,
    "maxX" : 753,
    "minY" : 64,
    "maxY" : 172,
    "prop" : {
      "x" : 665,
      "y" : 64,
      "width" : 49,
      "height" : 25
    },
    "textPosition" : {
      "x" : 668,
      "y" : 66
    },
    "connectors" : [ {
      "edgeId" : 68451,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 697,
          "y" : 95
        },
        "to" : {
          "x" : 753,
          "y" : 172
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 704,
          "y" : 98
        },
        "b" : {
          "x" : 697,
          "y" : 95
        },
        "c" : {
          "x" : 698,
          "y" : 103
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 698,
          "y" : 103
        }
      }
    } ]
  }, {
    "id" : 68452,
    "reactomeId" : 10169963,
    "displayName" : "Wls",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 640,
      "y" : 173
    },
    "minX" : 613,
    "maxX" : 753,
    "minY" : 156,
    "maxY" : 185,
    "prop" : {
      "x" : 613,
      "y" : 162,
      "width" : 54,
      "height" : 23
    },
    "textPosition" : {
      "x" : 625,
      "y" : 163
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 667,
          "y" : 162
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 667,
          "y" : 162
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 68451,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 670,
          "y" : 172
        },
        "to" : {
          "x" : 753,
          "y" : 172
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 677,
          "y" : 168
        },
        "b" : {
          "x" : 670,
          "y" : 172
        },
        "c" : {
          "x" : 677,
          "y" : 176
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 677,
          "y" : 176
        }
      }
    }, {
      "edgeId" : 68454,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 68455,
    "reactomeId" : 10169804,
    "displayName" : "Wls",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 359,
      "y" : 281
    },
    "minX" : 335,
    "maxX" : 390,
    "minY" : 260,
    "maxY" : 337,
    "prop" : {
      "x" : 335,
      "y" : 266,
      "width" : 49,
      "height" : 31
    },
    "textPosition" : {
      "x" : 345,
      "y" : 271
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 384,
          "y" : 266
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 384,
          "y" : 266
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 68454,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 68456,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 358,
          "y" : 300
        },
        "to" : {
          "x" : 358,
          "y" : 337
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 68457,
    "reactomeId" : 10169797,
    "displayName" : "VPS35:VPS29:VPS26",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 504,
      "y" : 284
    },
    "minX" : 358,
    "maxX" : 575,
    "minY" : 267,
    "maxY" : 440,
    "prop" : {
      "x" : 439,
      "y" : 273,
      "width" : 130,
      "height" : 22
    },
    "textPosition" : {
      "x" : 456,
      "y" : 260
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 569,
          "y" : 273
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 569,
          "y" : 273
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 68456,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 473,
          "y" : 298
        },
        "to" : {
          "x" : 358,
          "y" : 337
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 68462,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 507,
          "y" : 298
        },
        "to" : {
          "x" : 558,
          "y" : 440
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 513,
          "y" : 303
        },
        "b" : {
          "x" : 507,
          "y" : 298
        },
        "c" : {
          "x" : 506,
          "y" : 306
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 506,
          "y" : 306
        }
      }
    } ]
  }, {
    "id" : 68459,
    "reactomeId" : 10169813,
    "displayName" : "WLS:retromer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 355,
      "y" : 461
    },
    "minX" : 314,
    "maxX" : 402,
    "minY" : 438,
    "maxY" : 478,
    "prop" : {
      "x" : 314,
      "y" : 444,
      "width" : 82,
      "height" : 34
    },
    "textPosition" : {
      "x" : 323,
      "y" : 443
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 396,
          "y" : 444
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 396,
          "y" : 444
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 68456,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 68460,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 68458,
    "reactomeId" : 10169811,
    "displayName" : "SNX3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 484,
      "y" : 345
    },
    "minX" : 358,
    "maxX" : 558,
    "minY" : 328,
    "maxY" : 440,
    "prop" : {
      "x" : 464,
      "y" : 334,
      "width" : 40,
      "height" : 22
    },
    "textPosition" : {
      "x" : 464,
      "y" : 334
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 504,
          "y" : 334
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 504,
          "y" : 334
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 68456,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 461,
          "y" : 343
        },
        "to" : {
          "x" : 358,
          "y" : 337
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 68462,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 492,
          "y" : 359
        },
        "to" : {
          "x" : 558,
          "y" : 440
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 499,
          "y" : 362
        },
        "b" : {
          "x" : 492,
          "y" : 359
        },
        "c" : {
          "x" : 493,
          "y" : 367
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 493,
          "y" : 367
        }
      }
    } ]
  }, {
    "id" : 68461,
    "reactomeId" : 10169817,
    "displayName" : "WLS:retromer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 489,
      "y" : 467
    },
    "minX" : 448,
    "maxX" : 536,
    "minY" : 443,
    "maxY" : 485,
    "prop" : {
      "x" : 448,
      "y" : 449,
      "width" : 82,
      "height" : 36
    },
    "textPosition" : {
      "x" : 457,
      "y" : 450
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 530,
          "y" : 449
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 530,
          "y" : 449
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 68460,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 68462,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 68464,
    "reactomeId" : 10171644,
    "displayName" : "WLS:WNT",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 989,
      "y" : 273
    },
    "minX" : 951,
    "maxX" : 1033,
    "minY" : 255,
    "maxY" : 285,
    "prop" : {
      "x" : 951,
      "y" : 261,
      "width" : 76,
      "height" : 24
    },
    "textPosition" : {
      "x" : 957,
      "y" : 264
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1027,
          "y" : 261
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1027,
          "y" : 261
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 68465,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 68463,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 68466,
    "reactomeId" : 10171684,
    "displayName" : "WLS:WNT",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 997,
      "y" : 114
    },
    "minX" : 962,
    "maxX" : 1038,
    "minY" : 93,
    "maxY" : 129,
    "prop" : {
      "x" : 962,
      "y" : 99,
      "width" : 70,
      "height" : 30
    },
    "textPosition" : {
      "x" : 965,
      "y" : 108
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1032,
          "y" : 99
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1032,
          "y" : 99
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 68465,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 68443,
    "reactomeId" : 10169912,
    "displayName" : "palmitoleyl-N-glycosylated WNTs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 699,
      "y" : 782
    },
    "minX" : 637,
    "maxX" : 762,
    "minY" : 759,
    "maxY" : 806,
    "prop" : {
      "x" : 637,
      "y" : 759,
      "width" : 125,
      "height" : 47
    },
    "textPosition" : {
      "x" : 638,
      "y" : 765
    },
    "connectors" : [ {
      "edgeId" : 68442,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 68477,
    "reactomeId" : 10223319,
    "displayName" : "TCF dependent signaling in response to WNT",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 530,
      "y" : 29
    },
    "minX" : 471,
    "maxX" : 589,
    "minY" : 0,
    "maxY" : 59,
    "prop" : {
      "x" : 471,
      "y" : 0,
      "width" : 118,
      "height" : 59
    },
    "textPosition" : {
      "x" : 472,
      "y" : -6
    },
    "connectors" : [ ]
  }, {
    "id" : 68445,
    "reactomeId" : 10169952,
    "displayName" : "Tmed5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 610,
      "y" : 601
    },
    "minX" : 584,
    "maxX" : 676,
    "minY" : 578,
    "maxY" : 616,
    "prop" : {
      "x" : 584,
      "y" : 586,
      "width" : 52,
      "height" : 30
    },
    "textPosition" : {
      "x" : 585,
      "y" : 590
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 636,
          "y" : 586
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 636,
          "y" : 586
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 68442,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 639,
          "y" : 592
        },
        "to" : {
          "x" : 676,
          "y" : 580
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 671,
          "y" : 586
        },
        "b" : {
          "x" : 676,
          "y" : 580
        },
        "c" : {
          "x" : 668,
          "y" : 578
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 668,
          "y" : 578
        }
      }
    } ]
  }, {
    "id" : 68444,
    "reactomeId" : 10169948,
    "displayName" : "palmitoleyl-N-glycosylated WNTs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 682,
      "y" : 514
    },
    "minX" : 619,
    "maxX" : 745,
    "minY" : 460,
    "maxY" : 532,
    "prop" : {
      "x" : 619,
      "y" : 496,
      "width" : 126,
      "height" : 36
    },
    "textPosition" : {
      "x" : 620,
      "y" : 496
    },
    "connectors" : [ {
      "edgeId" : 68442,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 68446,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 682,
          "y" : 490
        },
        "to" : {
          "x" : 683,
          "y" : 460
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 68447,
    "reactomeId" : 10169815,
    "displayName" : "Wls",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 611,
      "y" : 419
    },
    "minX" : 558,
    "maxX" : 683,
    "minY" : 401,
    "maxY" : 460,
    "prop" : {
      "x" : 587,
      "y" : 407,
      "width" : 48,
      "height" : 24
    },
    "textPosition" : {
      "x" : 596,
      "y" : 408
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 635,
          "y" : 407
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 635,
          "y" : 407
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 68446,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 632,
          "y" : 434
        },
        "to" : {
          "x" : 683,
          "y" : 460
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 68462,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 584,
          "y" : 428
        },
        "to" : {
          "x" : 558,
          "y" : 440
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 579,
          "y" : 435
        },
        "b" : {
          "x" : 584,
          "y" : 428
        },
        "c" : {
          "x" : 576,
          "y" : 427
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 576,
          "y" : 427
        }
      }
    } ]
  }, {
    "id" : 68478,
    "reactomeId" : 10224481,
    "displayName" : "Beta-catenin independent WNT signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 809,
      "y" : 35
    },
    "minX" : 746,
    "maxX" : 872,
    "minY" : 6,
    "maxY" : 65,
    "prop" : {
      "x" : 746,
      "y" : 6,
      "width" : 126,
      "height" : 59
    },
    "textPosition" : {
      "x" : 757,
      "y" : 7
    },
    "connectors" : [ ]
  } ],
  "edges" : [ {
    "id" : 68449,
    "reactomeId" : 10170035,
    "displayName" : "WNT ligands traffic to the plasma membrane",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 782,
      "y" : 318
    },
    "minX" : 744,
    "maxX" : 838,
    "minY" : 185,
    "maxY" : 401,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 744,
        "y" : 401
      },
      "to" : {
        "x" : 782,
        "y" : 318
      }
    }, {
      "from" : {
        "x" : 782,
        "y" : 318
      },
      "to" : {
        "x" : 838,
        "y" : 185
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 839,
        "y" : 193
      },
      "b" : {
        "x" : 838,
        "y" : 185
      },
      "c" : {
        "x" : 832,
        "y" : 190
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 832,
        "y" : 190
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 776,
        "y" : 312
      },
      "b" : {
        "x" : 788,
        "y" : 324
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 782,
        "y" : 318
      }
    },
    "inputs" : [ {
      "id" : 68448
    } ],
    "outputs" : [ {
      "id" : 68450
    } ]
  }, {
    "id" : 68465,
    "reactomeId" : 10171686,
    "displayName" : "WNTs are secreted in exosomes",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 988,
      "y" : 200
    },
    "minX" : 982,
    "maxX" : 995,
    "minY" : 132,
    "maxY" : 258,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 988,
        "y" : 258
      },
      "to" : {
        "x" : 988,
        "y" : 200
      }
    }, {
      "from" : {
        "x" : 988,
        "y" : 200
      },
      "to" : {
        "x" : 995,
        "y" : 132
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 998,
        "y" : 139
      },
      "b" : {
        "x" : 995,
        "y" : 132
      },
      "c" : {
        "x" : 990,
        "y" : 138
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 990,
        "y" : 138
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 982,
        "y" : 194
      },
      "b" : {
        "x" : 994,
        "y" : 206
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 988,
        "y" : 200
      }
    },
    "inputs" : [ {
      "id" : 68464
    } ],
    "outputs" : [ {
      "id" : 68466
    } ]
  }, {
    "id" : 68451,
    "reactomeId" : 10170033,
    "displayName" : "secretion of WNT ligands",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 773,
      "y" : 173
    },
    "minX" : 753,
    "maxX" : 808,
    "minY" : 167,
    "maxY" : 179,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 808,
        "y" : 171
      },
      "to" : {
        "x" : 773,
        "y" : 173
      }
    }, {
      "from" : {
        "x" : 773,
        "y" : 173
      },
      "to" : {
        "x" : 753,
        "y" : 172
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 773,
        "y" : 173
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 773,
        "y" : 173
      }
    },
    "inputs" : [ {
      "id" : 68450
    } ],
    "outputs" : [ {
      "id" : 68452,
      "points" : [ {
        "x" : 670,
        "y" : 172
      } ]
    }, {
      "id" : 68453,
      "points" : [ {
        "x" : 697,
        "y" : 95
      } ]
    } ]
  }, {
    "id" : 68454,
    "reactomeId" : 10170037,
    "displayName" : "WLS is endocytosed to the early endosome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 547,
      "y" : 220
    },
    "minX" : 387,
    "maxX" : 617,
    "minY" : 188,
    "maxY" : 273,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 617,
        "y" : 188
      },
      "to" : {
        "x" : 547,
        "y" : 220
      }
    }, {
      "from" : {
        "x" : 547,
        "y" : 220
      },
      "to" : {
        "x" : 387,
        "y" : 273
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 392,
        "y" : 267
      },
      "b" : {
        "x" : 387,
        "y" : 273
      },
      "c" : {
        "x" : 395,
        "y" : 275
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 395,
        "y" : 275
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 541,
        "y" : 214
      },
      "b" : {
        "x" : 553,
        "y" : 226
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 547,
        "y" : 220
      }
    },
    "inputs" : [ {
      "id" : 68452
    } ],
    "outputs" : [ {
      "id" : 68455
    } ]
  }, {
    "id" : 68456,
    "reactomeId" : 10169957,
    "displayName" : "Retromer associates with WLS",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 357,
      "y" : 372
    },
    "minX" : 351,
    "maxX" : 363,
    "minY" : 337,
    "maxY" : 441,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 358,
        "y" : 337
      },
      "to" : {
        "x" : 357,
        "y" : 372
      }
    }, {
      "from" : {
        "x" : 357,
        "y" : 372
      },
      "to" : {
        "x" : 355,
        "y" : 441
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 351,
        "y" : 434
      },
      "b" : {
        "x" : 355,
        "y" : 441
      },
      "c" : {
        "x" : 359,
        "y" : 434
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 359,
        "y" : 434
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 357,
        "y" : 372
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 357,
        "y" : 372
      }
    },
    "inputs" : [ {
      "id" : 68457,
      "points" : [ {
        "x" : 473,
        "y" : 298
      } ]
    }, {
      "id" : 68455,
      "points" : [ {
        "x" : 358,
        "y" : 300
      } ]
    }, {
      "id" : 68458,
      "points" : [ {
        "x" : 461,
        "y" : 343
      } ]
    } ],
    "outputs" : [ {
      "id" : 68459
    } ]
  }, {
    "id" : 68442,
    "reactomeId" : 10169954,
    "displayName" : "WNT ligands traffic to the Golgi",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 685,
      "y" : 577
    },
    "minX" : 679,
    "maxX" : 697,
    "minY" : 538,
    "maxY" : 753,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 697,
        "y" : 753
      },
      "to" : {
        "x" : 685,
        "y" : 577
      }
    }, {
      "from" : {
        "x" : 685,
        "y" : 577
      },
      "to" : {
        "x" : 682,
        "y" : 538
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 687,
        "y" : 545
      },
      "b" : {
        "x" : 682,
        "y" : 538
      },
      "c" : {
        "x" : 679,
        "y" : 545
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 679,
        "y" : 545
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 679,
        "y" : 571
      },
      "b" : {
        "x" : 691,
        "y" : 583
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 685,
        "y" : 577
      }
    },
    "inputs" : [ {
      "id" : 68443
    } ],
    "outputs" : [ {
      "id" : 68444
    } ],
    "activators" : [ {
      "id" : 68445,
      "points" : [ {
        "x" : 639,
        "y" : 592
      } ]
    } ]
  }, {
    "id" : 68460,
    "reactomeId" : 10169819,
    "displayName" : "Retromer recycles WLS to the Golgi",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 416,
      "y" : 464
    },
    "minX" : 399,
    "maxX" : 445,
    "minY" : 458,
    "maxY" : 470,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 399,
        "y" : 463
      },
      "to" : {
        "x" : 416,
        "y" : 464
      }
    }, {
      "from" : {
        "x" : 416,
        "y" : 464
      },
      "to" : {
        "x" : 445,
        "y" : 465
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 438,
        "y" : 469
      },
      "b" : {
        "x" : 445,
        "y" : 465
      },
      "c" : {
        "x" : 438,
        "y" : 461
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 438,
        "y" : 461
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 410,
        "y" : 458
      },
      "b" : {
        "x" : 422,
        "y" : 470
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 416,
        "y" : 464
      }
    },
    "inputs" : [ {
      "id" : 68459
    } ],
    "outputs" : [ {
      "id" : 68461
    } ]
  }, {
    "id" : 68463,
    "reactomeId" : 10171688,
    "displayName" : "WLS:WNT complex is internalized for maturation into exosomes",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 900,
      "y" : 218
    },
    "minX" : 856,
    "maxX" : 969,
    "minY" : 185,
    "maxY" : 258,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 856,
        "y" : 185
      },
      "to" : {
        "x" : 900,
        "y" : 218
      }
    }, {
      "from" : {
        "x" : 900,
        "y" : 218
      },
      "to" : {
        "x" : 969,
        "y" : 258
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 961,
        "y" : 258
      },
      "b" : {
        "x" : 969,
        "y" : 258
      },
      "c" : {
        "x" : 965,
        "y" : 251
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 965,
        "y" : 251
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 894,
        "y" : 212
      },
      "b" : {
        "x" : 906,
        "y" : 224
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 900,
        "y" : 218
      }
    },
    "inputs" : [ {
      "id" : 68450
    } ],
    "outputs" : [ {
      "id" : 68464
    } ]
  }, {
    "id" : 68446,
    "reactomeId" : 10169961,
    "displayName" : "WLS binds WNT ligands in the Golgi",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 696,
      "y" : 451
    },
    "minX" : 683,
    "maxX" : 723,
    "minY" : 432,
    "maxY" : 460,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 683,
        "y" : 460
      },
      "to" : {
        "x" : 696,
        "y" : 451
      }
    }, {
      "from" : {
        "x" : 696,
        "y" : 451
      },
      "to" : {
        "x" : 723,
        "y" : 432
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 720,
        "y" : 439
      },
      "b" : {
        "x" : 723,
        "y" : 432
      },
      "c" : {
        "x" : 715,
        "y" : 433
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 715,
        "y" : 433
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 696,
        "y" : 451
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 696,
        "y" : 451
      }
    },
    "inputs" : [ {
      "id" : 68444,
      "points" : [ {
        "x" : 682,
        "y" : 490
      } ]
    }, {
      "id" : 68447,
      "points" : [ {
        "x" : 632,
        "y" : 434
      } ]
    } ],
    "outputs" : [ {
      "id" : 68448
    } ]
  }, {
    "id" : 68462,
    "reactomeId" : 10170039,
    "displayName" : "WLS dissociates from retromer",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 551,
      "y" : 455
    },
    "minX" : 533,
    "maxX" : 558,
    "minY" : 440,
    "maxY" : 461,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 533,
        "y" : 459
      },
      "to" : {
        "x" : 551,
        "y" : 455
      }
    }, {
      "from" : {
        "x" : 551,
        "y" : 455
      },
      "to" : {
        "x" : 558,
        "y" : 440
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 545,
        "y" : 449
      },
      "b" : {
        "x" : 557,
        "y" : 461
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 551,
        "y" : 455
      }
    },
    "inputs" : [ {
      "id" : 68461
    } ],
    "outputs" : [ {
      "id" : 68457,
      "points" : [ {
        "x" : 507,
        "y" : 298
      } ]
    }, {
      "id" : 68458,
      "points" : [ {
        "x" : 492,
        "y" : 359
      } ]
    }, {
      "id" : 68447,
      "points" : [ {
        "x" : 584,
        "y" : 428
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 68467,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 493,
      "y" : 745
    },
    "minX" : 91,
    "maxX" : 895,
    "minY" : 596,
    "maxY" : 895,
    "prop" : {
      "x" : 91,
      "y" : 596,
      "width" : 804,
      "height" : 299
    },
    "textPosition" : {
      "x" : 412,
      "y" : 642
    },
    "insets" : {
      "x" : 101,
      "y" : 606,
      "width" : 784,
      "height" : 279
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 68443, 68445 ]
  }, {
    "id" : 68468,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 604,
      "y" : 557
    },
    "minX" : 0,
    "maxX" : 1209,
    "minY" : 151,
    "maxY" : 963,
    "prop" : {
      "x" : 0,
      "y" : 151,
      "width" : 1209,
      "height" : 812
    },
    "textPosition" : {
      "x" : 131,
      "y" : 502
    },
    "insets" : {
      "x" : 10,
      "y" : 161,
      "width" : 1189,
      "height" : 792
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 68467, 68442, 68449, 68451, 68452, 68450, 68472, 68471, 68454, 68458, 68457, 68460, 68465, 68463, 68475 ]
  }, {
    "id" : 68471,
    "reactomeId" : 17963,
    "displayName" : "Golgi lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 667,
      "y" : 480
    },
    "minX" : 485,
    "maxX" : 850,
    "minY" : 409,
    "maxY" : 552,
    "prop" : {
      "x" : 485,
      "y" : 409,
      "width" : 365,
      "height" : 143
    },
    "textPosition" : {
      "x" : 731,
      "y" : 454
    },
    "insets" : {
      "x" : 495,
      "y" : 419,
      "width" : 345,
      "height" : 123
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 68444, 68447, 68446, 68461, 68462, 68448 ]
  }, {
    "id" : 68473,
    "reactomeId" : 383505,
    "displayName" : "extracellular exosome",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 957,
      "y" : 79
    },
    "minX" : 884,
    "maxX" : 1031,
    "minY" : 42,
    "maxY" : 116,
    "prop" : {
      "x" : 884,
      "y" : 42,
      "width" : 147,
      "height" : 74
    },
    "textPosition" : {
      "x" : 904,
      "y" : 54
    },
    "insets" : {
      "x" : 894,
      "y" : 52,
      "width" : 127,
      "height" : 54
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 68466 ]
  }, {
    "id" : 68472,
    "reactomeId" : 171043,
    "displayName" : "early endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 250,
      "y" : 346
    },
    "minX" : 136,
    "maxX" : 365,
    "minY" : 239,
    "maxY" : 454,
    "prop" : {
      "x" : 136,
      "y" : 239,
      "width" : 229,
      "height" : 215
    },
    "textPosition" : {
      "x" : 165,
      "y" : 396
    },
    "insets" : {
      "x" : 146,
      "y" : 249,
      "width" : 209,
      "height" : 195
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 68456, 68459, 68455 ]
  }, {
    "id" : 68475,
    "reactomeId" : 3828046,
    "displayName" : "multivesicular body lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1001,
      "y" : 320
    },
    "minX" : 877,
    "maxX" : 1125,
    "minY" : 234,
    "maxY" : 406,
    "prop" : {
      "x" : 877,
      "y" : 234,
      "width" : 248,
      "height" : 172
    },
    "textPosition" : {
      "x" : 942,
      "y" : 360
    },
    "insets" : {
      "x" : 887,
      "y" : 244,
      "width" : 228,
      "height" : 152
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 68474 ]
  }, {
    "id" : 68474,
    "reactomeId" : 3828050,
    "displayName" : "multivesicular body, internal vesicle",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 995,
      "y" : 314
    },
    "minX" : 917,
    "maxX" : 1073,
    "minY" : 262,
    "maxY" : 366,
    "prop" : {
      "x" : 917,
      "y" : 262,
      "width" : 156,
      "height" : 104
    },
    "textPosition" : {
      "x" : 922,
      "y" : 299
    },
    "insets" : {
      "x" : 927,
      "y" : 272,
      "width" : 136,
      "height" : 84
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 68464 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 68480,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 728,
      "y" : 54
    },
    "minX" : 714,
    "maxX" : 743,
    "minY" : 48,
    "maxY" : 60,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 714,
        "y" : 58
      },
      "to" : {
        "x" : 743,
        "y" : 50
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 737,
        "y" : 56
      },
      "b" : {
        "x" : 743,
        "y" : 50
      },
      "c" : {
        "x" : 735,
        "y" : 48
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 735,
        "y" : 48
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 722,
        "y" : 48
      },
      "b" : {
        "x" : 734,
        "y" : 60
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 728,
        "y" : 54
      }
    },
    "inputs" : [ {
      "id" : 68453
    } ],
    "outputs" : [ {
      "id" : 68478
    } ]
  }, {
    "id" : 68479,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 625,
      "y" : 57
    },
    "minX" : 592,
    "maxX" : 659,
    "minY" : 46,
    "maxY" : 68,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 659,
        "y" : 68
      },
      "to" : {
        "x" : 592,
        "y" : 46
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 600,
        "y" : 44
      },
      "b" : {
        "x" : 592,
        "y" : 46
      },
      "c" : {
        "x" : 597,
        "y" : 52
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 597,
        "y" : 52
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 619,
        "y" : 51
      },
      "b" : {
        "x" : 631,
        "y" : 63
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 625,
        "y" : 57
      }
    },
    "inputs" : [ {
      "id" : 68453
    } ],
    "outputs" : [ {
      "id" : 68477
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1209,
  "minY" : 0,
  "maxY" : 963,
  "disease" : false
}