{
  "dbId" : 10224491,
  "stableId" : "R-RNO-3215018",
  "displayName" : "Processing and activation of SUMO",
  "nodes" : [ {
    "id" : 78145,
    "reactomeId" : 10168557,
    "displayName" : "Sumo2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 704,
      "y" : 228
    },
    "minX" : 674,
    "maxX" : 741,
    "minY" : 209,
    "maxY" : 241,
    "prop" : {
      "x" : 674,
      "y" : 215,
      "width" : 61,
      "height" : 26
    },
    "textPosition" : {
      "x" : 679,
      "y" : 217
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 735,
          "y" : 215
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 735,
          "y" : 215
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78143,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 78144,
    "reactomeId" : 10168555,
    "displayName" : "Sumo2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 702,
      "y" : 91
    },
    "minX" : 650,
    "maxX" : 761,
    "minY" : 70,
    "maxY" : 107,
    "prop" : {
      "x" : 650,
      "y" : 76,
      "width" : 105,
      "height" : 31
    },
    "textPosition" : {
      "x" : 677,
      "y" : 81
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 755,
          "y" : 76
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 755,
          "y" : 76
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78143,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 78147,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 132,
      "y" : 273
    },
    "minX" : 108,
    "maxX" : 207,
    "minY" : 257,
    "maxY" : 338,
    "prop" : {
      "x" : 108,
      "y" : 258,
      "width" : 49,
      "height" : 31
    },
    "textPosition" : {
      "x" : 117,
      "y" : 263
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 152,
          "y" : 263
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 152,
          "y" : 263
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78146,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 149,
          "y" : 292
        },
        "to" : {
          "x" : 207,
          "y" : 338
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 78149,
    "reactomeId" : 10168449,
    "displayName" : "SUMO1:UBA2:SAE1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 209,
      "y" : 526
    },
    "minX" : 144,
    "maxX" : 280,
    "minY" : 429,
    "maxY" : 599,
    "prop" : {
      "x" : 144,
      "y" : 511,
      "width" : 130,
      "height" : 30
    },
    "textPosition" : {
      "x" : 146,
      "y" : 520
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 274,
          "y" : 511
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 274,
          "y" : 511
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78146,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 209,
          "y" : 508
        },
        "to" : {
          "x" : 209,
          "y" : 429
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 205,
          "y" : 501
        },
        "b" : {
          "x" : 209,
          "y" : 508
        },
        "c" : {
          "x" : 213,
          "y" : 501
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 213,
          "y" : 501
        }
      }
    }, {
      "edgeId" : 78152,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 209,
          "y" : 544
        },
        "to" : {
          "x" : 209,
          "y" : 599
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 78148,
    "reactomeId" : 10168439,
    "displayName" : "UBA2:SAE1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 86,
      "y" : 320
    },
    "minX" : 42,
    "maxX" : 209,
    "minY" : 300,
    "maxY" : 695,
    "prop" : {
      "x" : 42,
      "y" : 306,
      "width" : 88,
      "height" : 28
    },
    "textPosition" : {
      "x" : 47,
      "y" : 313
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 130,
          "y" : 306
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 130,
          "y" : 306
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78146,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 133,
          "y" : 326
        },
        "to" : {
          "x" : 207,
          "y" : 338
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 78146,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 117,
          "y" : 337
        },
        "to" : {
          "x" : 193,
          "y" : 368
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 197,
          "y" : 369
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 197,
          "y" : 369
        }
      }
    }, {
      "edgeId" : 78152,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 85,
          "y" : 337
        },
        "to" : {
          "x" : 76,
          "y" : 692
        }
      }, {
        "from" : {
          "x" : 76,
          "y" : 692
        },
        "to" : {
          "x" : 209,
          "y" : 695
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 89,
          "y" : 344
        },
        "b" : {
          "x" : 85,
          "y" : 337
        },
        "c" : {
          "x" : 81,
          "y" : 344
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 81,
          "y" : 344
        }
      }
    }, {
      "edgeId" : 78152,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 86,
          "y" : 337
        },
        "to" : {
          "x" : 88,
          "y" : 642
        }
      }, {
        "from" : {
          "x" : 88,
          "y" : 642
        },
        "to" : {
          "x" : 193,
          "y" : 642
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 197,
          "y" : 642
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 197,
          "y" : 642
        }
      }
    } ]
  }, {
    "id" : 78151,
    "reactomeId" : 113541,
    "displayName" : "PPi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 170,
      "y" : 478
    },
    "minX" : 150,
    "maxX" : 209,
    "minY" : 429,
    "maxY" : 494,
    "prop" : {
      "x" : 150,
      "y" : 463,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 156,
      "y" : 468
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 185,
          "y" : 468
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 185,
          "y" : 468
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78146,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 182,
          "y" : 460
        },
        "to" : {
          "x" : 209,
          "y" : 429
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 184,
          "y" : 452
        },
        "b" : {
          "x" : 182,
          "y" : 460
        },
        "c" : {
          "x" : 190,
          "y" : 457
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 190,
          "y" : 457
        }
      }
    } ]
  }, {
    "id" : 78150,
    "reactomeId" : 164121,
    "displayName" : "AMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 128,
      "y" : 449
    },
    "minX" : 103,
    "maxX" : 209,
    "minY" : 429,
    "maxY" : 466,
    "prop" : {
      "x" : 103,
      "y" : 433,
      "width" : 50,
      "height" : 33
    },
    "textPosition" : {
      "x" : 111,
      "y" : 439
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 148,
          "y" : 438
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 148,
          "y" : 438
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78146,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 156,
          "y" : 442
        },
        "to" : {
          "x" : 209,
          "y" : 429
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 162,
          "y" : 436
        },
        "b" : {
          "x" : 156,
          "y" : 442
        },
        "c" : {
          "x" : 164,
          "y" : 444
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 164,
          "y" : 444
        }
      }
    } ]
  }, {
    "id" : 78153,
    "reactomeId" : 10168567,
    "displayName" : "Ube2i",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 153,
      "y" : 576
    },
    "minX" : 126,
    "maxX" : 209,
    "minY" : 556,
    "maxY" : 599,
    "prop" : {
      "x" : 126,
      "y" : 562,
      "width" : 54,
      "height" : 28
    },
    "textPosition" : {
      "x" : 131,
      "y" : 565
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 180,
          "y" : 562
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 180,
          "y" : 562
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78152,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 183,
          "y" : 587
        },
        "to" : {
          "x" : 209,
          "y" : 599
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 78155,
    "reactomeId" : 10168580,
    "displayName" : "RWDD3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 281,
      "y" : 625
    },
    "minX" : 218,
    "maxX" : 316,
    "minY" : 605,
    "maxY" : 642,
    "prop" : {
      "x" : 253,
      "y" : 611,
      "width" : 57,
      "height" : 28
    },
    "textPosition" : {
      "x" : 255,
      "y" : 614
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 310,
          "y" : 611
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 310,
          "y" : 611
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78152,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 250,
          "y" : 631
        },
        "to" : {
          "x" : 218,
          "y" : 640
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 224,
          "y" : 634
        },
        "b" : {
          "x" : 218,
          "y" : 640
        },
        "c" : {
          "x" : 226,
          "y" : 642
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 226,
          "y" : 642
        }
      }
    } ]
  }, {
    "id" : 78154,
    "reactomeId" : 10168575,
    "displayName" : "SUMO1:C93-UBE2I",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 211,
      "y" : 760
    },
    "minX" : 146,
    "maxX" : 283,
    "minY" : 695,
    "maxY" : 774,
    "prop" : {
      "x" : 146,
      "y" : 747,
      "width" : 131,
      "height" : 27
    },
    "textPosition" : {
      "x" : 151,
      "y" : 753
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 277,
          "y" : 747
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 277,
          "y" : 747
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78152,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 210,
          "y" : 744
        },
        "to" : {
          "x" : 209,
          "y" : 695
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 206,
          "y" : 737
        },
        "b" : {
          "x" : 210,
          "y" : 744
        },
        "c" : {
          "x" : 214,
          "y" : 737
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 214,
          "y" : 737
        }
      }
    } ]
  }, {
    "id" : 78137,
    "reactomeId" : 10168454,
    "displayName" : "Sumo1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 207,
      "y" : 91
    },
    "minX" : 152,
    "maxX" : 268,
    "minY" : 69,
    "maxY" : 107,
    "prop" : {
      "x" : 152,
      "y" : 75,
      "width" : 110,
      "height" : 32
    },
    "textPosition" : {
      "x" : 181,
      "y" : 80
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 262,
          "y" : 75
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 262,
          "y" : 75
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78136,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 78139,
    "reactomeId" : 10168477,
    "displayName" : "SENP1,2,5",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 340,
      "y" : 137
    },
    "minX" : 216,
    "maxX" : 694,
    "minY" : 123,
    "maxY" : 180,
    "prop" : {
      "x" : 299,
      "y" : 123,
      "width" : 83,
      "height" : 28
    },
    "textPosition" : {
      "x" : 304,
      "y" : 126
    },
    "connectors" : [ {
      "edgeId" : 78136,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 293,
          "y" : 144
        },
        "to" : {
          "x" : 224,
          "y" : 158
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 220,
          "y" : 159
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 220,
          "y" : 159
        }
      }
    }, {
      "edgeId" : 78140,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 388,
          "y" : 147
        },
        "to" : {
          "x" : 459,
          "y" : 166
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 462,
          "y" : 167
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 462,
          "y" : 167
        }
      }
    }, {
      "edgeId" : 78143,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 388,
          "y" : 141
        },
        "to" : {
          "x" : 686,
          "y" : 175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 690,
          "y" : 176
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 690,
          "y" : 176
        }
      }
    } ]
  }, {
    "id" : 78138,
    "reactomeId" : 10144215,
    "displayName" : "Sumo1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 209,
      "y" : 228
    },
    "minX" : 179,
    "maxX" : 246,
    "minY" : 207,
    "maxY" : 338,
    "prop" : {
      "x" : 179,
      "y" : 213,
      "width" : 61,
      "height" : 31
    },
    "textPosition" : {
      "x" : 184,
      "y" : 218
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 240,
          "y" : 213
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 240,
          "y" : 213
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78146,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 208,
          "y" : 247
        },
        "to" : {
          "x" : 207,
          "y" : 338
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 78136,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 78141,
    "reactomeId" : 10168488,
    "displayName" : "Sumo3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 477,
      "y" : 92
    },
    "minX" : 427,
    "maxX" : 533,
    "minY" : 71,
    "maxY" : 108,
    "prop" : {
      "x" : 427,
      "y" : 77,
      "width" : 100,
      "height" : 31
    },
    "textPosition" : {
      "x" : 451,
      "y" : 82
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 527,
          "y" : 77
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 527,
          "y" : 77
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78140,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 78142,
    "reactomeId" : 10168490,
    "displayName" : "Sumo3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 475,
      "y" : 228
    },
    "minX" : 447,
    "maxX" : 510,
    "minY" : 207,
    "maxY" : 243,
    "prop" : {
      "x" : 447,
      "y" : 213,
      "width" : 57,
      "height" : 30
    },
    "textPosition" : {
      "x" : 450,
      "y" : 217
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 504,
          "y" : 213
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 504,
          "y" : 213
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 78140,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 78146,
    "reactomeId" : 10168452,
    "displayName" : "Conjugation of SUMO1 to UBA2:SAE1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 208,
      "y" : 374
    },
    "minX" : 202,
    "maxX" : 214,
    "minY" : 338,
    "maxY" : 429,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 207,
        "y" : 338
      },
      "to" : {
        "x" : 208,
        "y" : 374
      }
    }, {
      "from" : {
        "x" : 208,
        "y" : 374
      },
      "to" : {
        "x" : 209,
        "y" : 429
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 202,
        "y" : 368
      },
      "b" : {
        "x" : 214,
        "y" : 380
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 208,
        "y" : 374
      }
    },
    "inputs" : [ {
      "id" : 78138,
      "points" : [ {
        "x" : 208,
        "y" : 247
      } ]
    }, {
      "id" : 78147,
      "points" : [ {
        "x" : 149,
        "y" : 292
      } ]
    }, {
      "id" : 78148,
      "points" : [ {
        "x" : 133,
        "y" : 326
      } ]
    } ],
    "outputs" : [ {
      "id" : 78149,
      "points" : [ {
        "x" : 209,
        "y" : 508
      } ]
    }, {
      "id" : 78150,
      "points" : [ {
        "x" : 156,
        "y" : 442
      } ]
    }, {
      "id" : 78151,
      "points" : [ {
        "x" : 182,
        "y" : 460
      } ]
    } ],
    "catalysts" : [ {
      "id" : 78148,
      "points" : [ {
        "x" : 117,
        "y" : 337
      } ]
    } ]
  }, {
    "id" : 78136,
    "reactomeId" : 10168480,
    "displayName" : "SENP1,2,5 proteolytically process SUMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 208,
      "y" : 161
    },
    "minX" : 202,
    "maxX" : 214,
    "minY" : 110,
    "maxY" : 210,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 207,
        "y" : 110
      },
      "to" : {
        "x" : 208,
        "y" : 161
      }
    }, {
      "from" : {
        "x" : 208,
        "y" : 161
      },
      "to" : {
        "x" : 208,
        "y" : 210
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 204,
        "y" : 203
      },
      "b" : {
        "x" : 208,
        "y" : 210
      },
      "c" : {
        "x" : 212,
        "y" : 203
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 212,
        "y" : 203
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 202,
        "y" : 155
      },
      "b" : {
        "x" : 214,
        "y" : 167
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 208,
        "y" : 161
      }
    },
    "inputs" : [ {
      "id" : 78137
    } ],
    "outputs" : [ {
      "id" : 78138
    } ],
    "catalysts" : [ {
      "id" : 78139,
      "points" : [ {
        "x" : 293,
        "y" : 144
      } ]
    } ]
  }, {
    "id" : 78152,
    "reactomeId" : 10168582,
    "displayName" : "Transfer of SUMO1 from E1 to UBE2I (UBC9)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 209,
      "y" : 642
    },
    "minX" : 203,
    "maxX" : 215,
    "minY" : 599,
    "maxY" : 695,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 209,
        "y" : 599
      },
      "to" : {
        "x" : 209,
        "y" : 642
      }
    }, {
      "from" : {
        "x" : 209,
        "y" : 642
      },
      "to" : {
        "x" : 209,
        "y" : 695
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 203,
        "y" : 636
      },
      "b" : {
        "x" : 215,
        "y" : 648
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 209,
        "y" : 642
      }
    },
    "inputs" : [ {
      "id" : 78153,
      "points" : [ {
        "x" : 183,
        "y" : 587
      } ]
    }, {
      "id" : 78149,
      "points" : [ {
        "x" : 209,
        "y" : 544
      } ]
    } ],
    "outputs" : [ {
      "id" : 78154,
      "points" : [ {
        "x" : 210,
        "y" : 744
      } ]
    }, {
      "id" : 78148,
      "points" : [ {
        "x" : 85,
        "y" : 337
      }, {
        "x" : 76,
        "y" : 692
      } ]
    } ],
    "catalysts" : [ {
      "id" : 78148,
      "points" : [ {
        "x" : 86,
        "y" : 337
      }, {
        "x" : 88,
        "y" : 642
      } ]
    } ],
    "activators" : [ {
      "id" : 78155,
      "points" : [ {
        "x" : 250,
        "y" : 631
      } ]
    } ]
  }, {
    "id" : 78140,
    "reactomeId" : 10168492,
    "displayName" : "SENP1,2,5 proteolytically process SUMO2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 474,
      "y" : 170
    },
    "minX" : 468,
    "maxX" : 480,
    "minY" : 111,
    "maxY" : 210,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 476,
        "y" : 111
      },
      "to" : {
        "x" : 474,
        "y" : 170
      }
    }, {
      "from" : {
        "x" : 474,
        "y" : 170
      },
      "to" : {
        "x" : 474,
        "y" : 210
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 470,
        "y" : 203
      },
      "b" : {
        "x" : 474,
        "y" : 210
      },
      "c" : {
        "x" : 478,
        "y" : 203
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 478,
        "y" : 203
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 468,
        "y" : 164
      },
      "b" : {
        "x" : 480,
        "y" : 176
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 474,
        "y" : 170
      }
    },
    "inputs" : [ {
      "id" : 78141
    } ],
    "outputs" : [ {
      "id" : 78142
    } ],
    "catalysts" : [ {
      "id" : 78139,
      "points" : [ {
        "x" : 388,
        "y" : 147
      } ]
    } ]
  }, {
    "id" : 78143,
    "reactomeId" : 10168559,
    "displayName" : "SENP1,2,5 proteolytically process SUMO3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 702,
      "y" : 177
    },
    "minX" : 696,
    "maxX" : 708,
    "minY" : 110,
    "maxY" : 212,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 702,
        "y" : 110
      },
      "to" : {
        "x" : 702,
        "y" : 177
      }
    }, {
      "from" : {
        "x" : 702,
        "y" : 177
      },
      "to" : {
        "x" : 703,
        "y" : 212
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 699,
        "y" : 205
      },
      "b" : {
        "x" : 703,
        "y" : 212
      },
      "c" : {
        "x" : 707,
        "y" : 205
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 707,
        "y" : 205
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 696,
        "y" : 171
      },
      "b" : {
        "x" : 708,
        "y" : 183
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 702,
        "y" : 177
      }
    },
    "inputs" : [ {
      "id" : 78144
    } ],
    "outputs" : [ {
      "id" : 78145
    } ],
    "catalysts" : [ {
      "id" : 78139,
      "points" : [ {
        "x" : 388,
        "y" : 141
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 78156,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 428,
      "y" : 432
    },
    "minX" : 0,
    "maxX" : 856,
    "minY" : 0,
    "maxY" : 865,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 856,
      "height" : 865
    },
    "textPosition" : {
      "x" : 14,
      "y" : 815
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 836,
      "height" : 845
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 78136, 78137, 78138, 78139, 78140, 78141, 78142, 78143, 78144, 78145, 78146, 78147, 78149, 78148, 78150, 78151, 78152, 78153, 78154, 78155 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ {
    "id" : 78157,
    "reactomeId" : 10224489,
    "displayName" : "SUMO is conjugated to E1 (UBA2:SAE1)",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 158,
      "y" : 377
    },
    "minX" : 32,
    "maxX" : 284,
    "minY" : 203,
    "maxY" : 551,
    "prop" : {
      "x" : 32,
      "y" : 254,
      "width" : 252,
      "height" : 42
    },
    "points" : [ {
      "x" : 32,
      "y" : 203
    }, {
      "x" : 284,
      "y" : 203
    }, {
      "x" : 284,
      "y" : 551
    }, {
      "x" : 32,
      "y" : 551
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 78159,
    "reactomeId" : 10224499,
    "displayName" : "SUMO is transferred from E1 to E2 (UBE2I, UBC9)",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 176,
      "y" : 540
    },
    "minX" : 32,
    "maxX" : 320,
    "minY" : 296,
    "maxY" : 784,
    "prop" : {
      "x" : 32,
      "y" : 551,
      "width" : 288,
      "height" : 233
    },
    "points" : [ {
      "x" : 32,
      "y" : 296
    }, {
      "x" : 320,
      "y" : 296
    }, {
      "x" : 320,
      "y" : 784
    }, {
      "x" : 32,
      "y" : 784
    } ],
    "colour" : "#008000"
  }, {
    "id" : 78158,
    "reactomeId" : 10224495,
    "displayName" : "SUMO is proteolytically processed",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 453,
      "y" : 159
    },
    "minX" : 142,
    "maxX" : 765,
    "minY" : 65,
    "maxY" : 254,
    "prop" : {
      "x" : 142,
      "y" : 65,
      "width" : 623,
      "height" : 138
    },
    "points" : [ {
      "x" : 142,
      "y" : 65
    }, {
      "x" : 765,
      "y" : 65
    }, {
      "x" : 765,
      "y" : 254
    }, {
      "x" : 142,
      "y" : 254
    } ],
    "colour" : "#dc3912"
  } ],
  "minX" : 0,
  "maxX" : 856,
  "minY" : 0,
  "maxY" : 865,
  "disease" : false
}