{ "dbId" : 10223073, "stId" : "R-RNO-194138", "speciesName" : "Rattus norvegicus", "nodes" : [ { "dbId" : 10123416, "stId" : "R-RNO-199453", "displayName" : "AKT:PIP3:THEM4/TRIB3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49182 ], "parents" : [ ], "children" : [ 10123414, 10123376 ] }, { "dbId" : 10123410, "stId" : "R-RNO-199437", "displayName" : "THEM4 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q566R0", "standardIdentifier" : "uniprot:Q566R0", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10123414 ], "children" : [ ] }, { "dbId" : 10224791, "stId" : "R-RNO-5673001", "displayName" : "RAF/MAP kinase cascade", "schemaClass" : "Pathway", "speciesId" : 48895, "diagramIds" : [ 49332 ] }, { "dbId" : 10175127, "stId" : "R-RNO-5218641", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2:SRC-1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49153, 49091, 49063 ], "parents" : [ ], "children" : [ 10175125, 548926 ] }, { "dbId" : 10123414, "stId" : "R-RNO-2400007", "displayName" : "THEM4/TRIB3 [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10123416 ], "children" : [ 10123412, 10123410 ] }, { "dbId" : 10175125, "stId" : "R-RNO-5218639", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:p-Y397-PTK2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49060 ], "parents" : [ 10175127 ], "children" : [ 10130022, 10172394 ] }, { "dbId" : 10123412, "stId" : "R-RNO-199447", "displayName" : "Trib3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q9WTQ6", "standardIdentifier" : "uniprot:Q9WTQ6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Trib3" ], "parents" : [ 10123414 ], "children" : [ ] }, { "dbId" : 10141845, "stId" : "R-RNO-450563", "displayName" : "Hspb1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P42930", "standardIdentifier" : "uniprot:P42930", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Hspb1" ], "parents" : [ 10175388 ], "children" : [ ] }, { "dbId" : 71185, "stId" : "R-ALL-71185", "displayName" : "ferroheme [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "60344", "standardIdentifier" : "chebi:60344", "referenceType" : "ReferenceMolecule", "parents" : [ 10175318, 10125346, 10125312 ], "children" : [ ] }, { "dbId" : 10123403, "stId" : "R-RNO-3006620", "displayName" : "MAPKAP1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q6AYF1", "standardIdentifier" : "uniprot:Q6AYF1", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10123405 ], "children" : [ ] }, { "dbId" : 10123407, "stId" : "R-RNO-9980228", "displayName" : "mTORC2:PIP3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49181 ], "parents" : [ ], "children" : [ 10116597, 10123396, 10116593, 10123405, 10123390 ] }, { "dbId" : 10123405, "stId" : "R-RNO-9980231", "displayName" : "MAPKAP1:PIP3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10123407 ], "children" : [ 179838, 10123403 ] }, { "dbId" : 10112128, "stId" : "R-RNO-74294", "displayName" : "CALM1:4xCa2+ [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49187 ], "parents" : [ 10125348 ], "children" : [ 10105584, 74016 ] }, { "dbId" : 10130052, "stId" : "R-RNO-377592", "displayName" : "phospho-p-Y419-SRC [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q9WUD9", "standardIdentifier" : "uniprot:Q9WUD9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Src" ], "parents" : [ 10173269 ], "children" : [ ] }, { "dbId" : 10123396, "stId" : "R-RNO-6795323", "displayName" : "Prr5 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q5FVG6", "standardIdentifier" : "uniprot:Q5FVG6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Prr5" ], "parents" : [ 10123407 ], "children" : [ ] }, { "dbId" : 10120890, "stId" : "R-RNO-187699", "displayName" : "MAPKAP kinase [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49302 ], "parents" : [ ], "children" : [ 10120881, 10120888 ] }, { "dbId" : 10175162, "stId" : "R-RNO-437181", "displayName" : "phospho-p-T410-PRKCZ [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P09217", "standardIdentifier" : "uniprot:P09217", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Prkcz", "Pkcz" ], "parents" : [ 10175172 ], "children" : [ ] }, { "dbId" : 10120888, "stId" : "R-RNO-187764", "displayName" : "MAPKAPK3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q66H84", "standardIdentifier" : "uniprot:Q66H84", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10120890 ], "children" : [ ] }, { "dbId" : 10108606, "stId" : "R-RNO-74789", "displayName" : "Pik3r1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q63787", "standardIdentifier" : "uniprot:Q63787", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Pik3r1" ], "parents" : [ 10108611 ], "children" : [ ] }, { "dbId" : 10120895, "stId" : "R-RNO-187760", "displayName" : "phospho-p-S272,T222,T334-MAPKAPK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q80ZF4", "standardIdentifier" : "uniprot:Q80ZF4", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10120901 ], "children" : [ ] }, { "dbId" : 10175165, "stId" : "R-RNO-5218731", "displayName" : "phospho-p-T497-PRKCA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P05696", "standardIdentifier" : "uniprot:P05696", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175172 ], "children" : [ ] }, { "dbId" : 10165949, "stId" : "R-RNO-2317313", "displayName" : "p-S-AKT:PDPK1:PIP3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49184 ], "parents" : [ ], "children" : [ 10111304, 10123386 ] }, { "dbId" : 10175155, "stId" : "R-RNO-5218772", "displayName" : "p-3Y-PAK2 dimer:CDC42:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10175157 ], "children" : [ 10175153, 10120616 ] }, { "dbId" : 10175153, "stId" : "R-RNO-5218799", "displayName" : "p-3Y-PAK2 dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10175155 ], "children" : [ 10175151 ] }, { "dbId" : 10120881, "stId" : "R-RNO-187743", "displayName" : "MAPKAPK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q80ZF4", "standardIdentifier" : "uniprot:Q80ZF4", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10120890 ], "children" : [ ] }, { "dbId" : 10175157, "stId" : "R-RNO-5218793", "displayName" : "VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49251 ], "parents" : [ ], "children" : [ 10175155, 10175148 ] }, { "dbId" : 10175146, "stId" : "R-RNO-5218745", "displayName" : "phospho-p-S21,Y420-FYN [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q62844", "standardIdentifier" : "uniprot:Q62844", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Fyn" ], "parents" : [ 10175148 ], "children" : [ ] }, { "dbId" : 10124974, "stId" : "R-RNO-212509", "displayName" : "ROCK1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q63644", "standardIdentifier" : "uniprot:Q63644", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10136946 ], "children" : [ ] }, { "dbId" : 10175151, "stId" : "R-RNO-5218705", "displayName" : "phospho-p-Y130,S141,T402-PAK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q64303", "standardIdentifier" : "uniprot:Q64303", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175153 ], "children" : [ ] }, { "dbId" : 548926, "stId" : "R-RNO-548926", "displayName" : "SRC_RAT [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49126, 49272, 49054 ], "identifier" : "Q9WUD9", "standardIdentifier" : "uniprot:Q9WUD9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Src" ], "parents" : [ 10172400, 10175127, 10175307, 10175206, 10173259 ], "children" : [ ] }, { "dbId" : 10175148, "stId" : "R-RNO-5218780", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49237 ], "parents" : [ 10175157, 10175223, 10175234, 10175337 ], "children" : [ 10175143, 10175146 ] }, { "dbId" : 10175139, "stId" : "R-RNO-171016", "displayName" : "MAP kinase p38 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10175141 ], "children" : [ 10152198, 10138749, 10152204, 10152202 ] }, { "dbId" : 10175143, "stId" : "R-RNO-5218798", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49226 ], "parents" : [ 10175148, 10175194, 10175192 ], "children" : [ 10130417, 10172387 ] }, { "dbId" : 10175141, "stId" : "R-RNO-189828", "displayName" : "MAP kinase p38 (Mg2+ cofactor) [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49255 ], "parents" : [ ], "children" : [ 10175139, 29926 ] }, { "dbId" : 10175194, "stId" : "R-RNO-5218795", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-Y420-FYN [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49232 ], "parents" : [ ], "children" : [ 10135639, 10175143 ] }, { "dbId" : 10126040, "stId" : "R-RNO-201857", "displayName" : "G-actin [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10135745 ], "children" : [ 10126038, 113592 ] }, { "dbId" : 352327, "stId" : "R-ALL-352327", "displayName" : "O2 [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49221 ], "identifier" : "15379", "standardIdentifier" : "chebi:15379", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10175192, "stId" : "R-RNO-5218786", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:FYN [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49229 ], "parents" : [ ], "children" : [ 10175143, 374400 ] }, { "dbId" : 10175199, "stId" : "R-RNO-210014", "displayName" : "Pxn [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49097 ], "identifier" : "Q66H76", "standardIdentifier" : "uniprot:Q66H76", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Pxn" ], "parents" : [ 10175208 ], "children" : [ ] }, { "dbId" : 433728, "stId" : "R-RNO-433728", "displayName" : "Actin [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P63259", "standardIdentifier" : "uniprot:P63259", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Actg1", "Actg" ], "parents" : [ 10126038 ], "children" : [ ] }, { "dbId" : 10139858, "stId" : "R-RNO-5340329", "displayName" : "PIP3:VAV1,2,3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49149 ], "parents" : [ ], "children" : [ 10139175, 179838 ] }, { "dbId" : 10175187, "stId" : "R-RNO-5218758", "displayName" : "p-PKC [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49284 ], "parents" : [ 10175228 ], "children" : [ 10175175, 10175185, 10175181, 10175179 ] }, { "dbId" : 10175185, "stId" : "R-RNO-4332337", "displayName" : "phospho-p-T497,T638,S657-PRKCA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P05696", "standardIdentifier" : "uniprot:P05696", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175187 ], "children" : [ ] }, { "dbId" : 10126038, "stId" : "R-RNO-201859", "displayName" : "ACTB, ACTG1 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10126040 ], "children" : [ 10126036, 433728 ] }, { "dbId" : 10126036, "stId" : "R-RNO-201858", "displayName" : "Actb [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P60711", "standardIdentifier" : "uniprot:P60711", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Actb" ], "parents" : [ 10126038 ], "children" : [ ] }, { "dbId" : 10175179, "stId" : "R-RNO-5218706", "displayName" : "phospho-p-T500,T642,S661-PRKCB [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P68403", "standardIdentifier" : "uniprot:P68403", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175187 ], "children" : [ ] }, { "dbId" : 10139851, "stId" : "R-RNO-437946", "displayName" : "phospho-Vav1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P54100", "standardIdentifier" : "uniprot:P54100", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Vav1" ], "parents" : [ 10162511 ], "children" : [ ] }, { "dbId" : 10120907, "stId" : "R-RNO-170997", "displayName" : "p-p38 MAPK alpha/beta [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10120909 ], "children" : [ 10120903, 10120905 ] }, { "dbId" : 10125512, "stId" : "R-RNO-202320", "displayName" : "PLCG1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49266 ], "identifier" : "P10686", "standardIdentifier" : "uniprot:P10686", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Plcg1" ], "parents" : [ 10173245 ], "children" : [ ] }, { "dbId" : 10108617, "stId" : "R-RNO-74787", "displayName" : "Pik3ca [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A0G2K344", "standardIdentifier" : "uniprot:A0A0G2K344", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Pik3ca" ], "parents" : [ 10108621 ], "children" : [ ] }, { "dbId" : 10120905, "stId" : "R-RNO-428935", "displayName" : "phospho-p-T180,Y182-MAPK14 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P70618", "standardIdentifier" : "uniprot:P70618", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Mapk14", "Csbp1", "Csbp2" ], "parents" : [ 10120907 ], "children" : [ ] }, { "dbId" : 10108623, "stId" : "R-RNO-74693", "displayName" : "PI3K [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49140 ], "parents" : [ 10175255, 10175245 ], "children" : [ 10108611, 10108621 ] }, { "dbId" : 10175181, "stId" : "R-RNO-5218734", "displayName" : "phospho-p-T507,S645,S664-PRKCD [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P09215", "standardIdentifier" : "uniprot:P09215", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Prkcd", "Pkcd" ], "parents" : [ 10175187 ], "children" : [ ] }, { "dbId" : 10108621, "stId" : "R-RNO-74689", "displayName" : "PI3K-catalytic subunit [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10108623 ], "children" : [ 451713, 10108617 ] }, { "dbId" : 10120909, "stId" : "R-RNO-170993", "displayName" : "Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49256 ], "parents" : [ ], "children" : [ 29926, 10120907 ] }, { "dbId" : 10120899, "stId" : "R-RNO-187723", "displayName" : "phospho-p-S,2T-MAPKAPK3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q66H84", "standardIdentifier" : "uniprot:Q66H84", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10120901 ], "children" : [ ] }, { "dbId" : 10108611, "stId" : "R-RNO-74688", "displayName" : "PI3K-regulatory subunit [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10108623 ], "children" : [ 10108609, 10108606 ] }, { "dbId" : 10139843, "stId" : "R-RNO-194866", "displayName" : "RHOA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P61589", "standardIdentifier" : "uniprot:P61589", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10171928 ], "children" : [ ] }, { "dbId" : 10175170, "stId" : "R-RNO-5218746", "displayName" : "phospho-p-T507-PRKCD [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P09215", "standardIdentifier" : "uniprot:P09215", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Prkcd", "Pkcd" ], "parents" : [ 10175172 ], "children" : [ ] }, { "dbId" : 10135745, "stId" : "R-RNO-201877", "displayName" : "F-actin [cytosol]", "schemaClass" : "Polymer", "speciesId" : 48895, "diagramIds" : [ 49261 ], "parents" : [ 10175390 ], "children" : [ 10126040 ] }, { "dbId" : 10108609, "stId" : "R-RNO-74791", "displayName" : "Pik3r2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q63788", "standardIdentifier" : "uniprot:Q63788", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Pik3r2" ], "parents" : [ 10108611 ], "children" : [ ] }, { "dbId" : 10175168, "stId" : "R-RNO-5218728", "displayName" : "phospho-p-T500-PRKCB [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P68403", "standardIdentifier" : "uniprot:P68403", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175172 ], "children" : [ ] }, { "dbId" : 10175175, "stId" : "R-RNO-5218698", "displayName" : "phospho-p-T410,T563-PRKCZ [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P09217", "standardIdentifier" : "uniprot:P09217", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Prkcz", "Pkcz" ], "parents" : [ 10175187 ], "children" : [ ] }, { "dbId" : 10120903, "stId" : "R-RNO-171009", "displayName" : "phospho-p-T180,Y182-MAPK11 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A0G2KB06", "standardIdentifier" : "uniprot:A0A0G2KB06", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10120907 ], "children" : [ ] }, { "dbId" : 10112199, "stId" : "R-RNO-58200", "displayName" : "PRKCD [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P09215", "standardIdentifier" : "uniprot:P09215", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Prkcd", "Pkcd" ], "parents" : [ 10175268 ], "children" : [ ] }, { "dbId" : 10112196, "stId" : "R-RNO-58196", "displayName" : "PRKCA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P05696", "standardIdentifier" : "uniprot:P05696", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175268 ], "children" : [ ] }, { "dbId" : 10120901, "stId" : "R-RNO-187726", "displayName" : "p-S272,T222,T334-MAPKAPK2, p-S,2T-MAPKAPK3 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49264 ], "parents" : [ ], "children" : [ 10120899, 10120895 ] }, { "dbId" : 10175172, "stId" : "R-RNO-5218754", "displayName" : "p-PKCA,p-PKCB,p-PKCZ,p-PKCD [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49278 ], "parents" : [ ], "children" : [ 10175168, 10175170, 10175165, 10175162 ] }, { "dbId" : 10123007, "stId" : "R-RNO-195361", "displayName" : "VEGF [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49022 ], "parents" : [ ], "children" : [ 10122788, 10122806, 10122782, 10122830, 10122824 ] }, { "dbId" : 10175228, "stId" : "R-RNO-5218773", "displayName" : "DAG:active PKC:Ca+2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49288 ], "parents" : [ ], "children" : [ 10175187, 112275, 74016 ] }, { "dbId" : 10125042, "stId" : "R-RNO-201621", "displayName" : "PTK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49056 ], "identifier" : "O35346", "standardIdentifier" : "uniprot:O35346", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Ptk2", "Fak", "Fak1" ], "parents" : [ 10173219 ], "children" : [ ] }, { "dbId" : 10175219, "stId" : "R-RNO-5218794", "displayName" : "p-2Y-PAK2 dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10175221 ], "children" : [ 10135921 ] }, { "dbId" : 10127091, "stId" : "R-RNO-430152", "displayName" : "Vav3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A8I5ZPB5", "standardIdentifier" : "uniprot:A0A8I5ZPB5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Vav3" ], "parents" : [ 10139175 ], "children" : [ ] }, { "dbId" : 10105584, "stId" : "R-RNO-9016707", "displayName" : "CALM1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P0DP31", "standardIdentifier" : "uniprot:P0DP31", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10112128 ], "children" : [ ] }, { "dbId" : 10175223, "stId" : "R-RNO-5218792", "displayName" : "VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-2Y-PAK2:CDC42:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49248 ], "parents" : [ ], "children" : [ 10175221, 10175148 ] }, { "dbId" : 10175221, "stId" : "R-RNO-5218800", "displayName" : "p-2Y-PAK2 dimer:CDC42:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10175223 ], "children" : [ 10175219, 10120616 ] }, { "dbId" : 10127083, "stId" : "R-RNO-195066", "displayName" : "Vav1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P54100", "standardIdentifier" : "uniprot:P54100", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Vav1" ], "parents" : [ 10139175 ], "children" : [ ] }, { "dbId" : 10175208, "stId" : "R-RNO-5218781", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:PXN [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49098 ], "parents" : [ ], "children" : [ 10175206, 10175199 ] }, { "dbId" : 10127087, "stId" : "R-RNO-195012", "displayName" : "Vav2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "D3ZYG0", "standardIdentifier" : "uniprot:D3ZYG0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Vav2" ], "parents" : [ 10139175 ], "children" : [ ] }, { "dbId" : 10175214, "stId" : "R-RNO-5218756", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49102 ], "parents" : [ 10175289 ], "children" : [ 10175206, 10175212 ] }, { "dbId" : 10139885, "stId" : "R-RNO-442287", "displayName" : "phospho-Vav3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A8I5ZPB5", "standardIdentifier" : "uniprot:A0A8I5ZPB5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Vav3" ], "parents" : [ 10162511 ], "children" : [ ] }, { "dbId" : 10175212, "stId" : "R-RNO-5218693", "displayName" : "phospho-Pxn [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q66H76", "standardIdentifier" : "uniprot:Q66H76", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Pxn" ], "parents" : [ 10175214 ], "children" : [ ] }, { "dbId" : 10175202, "stId" : "R-RNO-5218694", "displayName" : "phospho-p-6Y,S732-PTK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "O35346", "standardIdentifier" : "uniprot:O35346", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Ptk2", "Fak", "Fak1" ], "parents" : [ 10175204 ], "children" : [ ] }, { "dbId" : 10139873, "stId" : "R-RNO-442307", "displayName" : "phospho-Vav2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "D3ZYG0", "standardIdentifier" : "uniprot:D3ZYG0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Vav2" ], "parents" : [ 10162511 ], "children" : [ ] }, { "dbId" : 179838, "stId" : "R-ALL-179838", "displayName" : "PI(3,4,5)P3 [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49146, 49116 ], "identifier" : "57836", "standardIdentifier" : "chebi:57836", "referenceType" : "ReferenceMolecule", "parents" : [ 10139858, 10175262, 10162613, 10123376, 10123386, 10111304, 10123405 ], "children" : [ ] }, { "dbId" : 10175206, "stId" : "R-RNO-5218757", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49094 ], "parents" : [ 10175208, 10175214, 10175287 ], "children" : [ 10175204, 10125341, 548926 ] }, { "dbId" : 10175204, "stId" : "R-RNO-5218760", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:p-6Y,S732-PTK2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10175206 ], "children" : [ 10175202, 10172394 ] }, { "dbId" : 10176539, "stId" : "R-RNO-5357459", "displayName" : "p-S665-VE-cadherin-Catenin complex [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49171 ], "parents" : [ ], "children" : [ 10136902, 10136889, 10176537, 10136906 ] }, { "dbId" : 10125339, "stId" : "R-RNO-202113", "displayName" : "eNOS:CaM:HSP90:p-AKT1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49197 ], "parents" : [ ], "children" : [ 10125335, 10125337 ] }, { "dbId" : 10176537, "stId" : "R-RNO-5357435", "displayName" : "phospho-p-S665-VE-cadherin [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A0G2K0I6", "standardIdentifier" : "uniprot:A0A0G2K0I6", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10176539 ], "children" : [ ] }, { "dbId" : 10171928, "stId" : "R-RNO-3858473", "displayName" : "RHOA:GTP:Mg2+ [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10175309 ], "children" : [ 29438, 10139843, 29926 ] }, { "dbId" : 10125337, "stId" : "R-RNO-199430", "displayName" : "phospho-p-T308,S473-AKT1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P47196", "standardIdentifier" : "uniprot:P47196", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Akt1" ], "parents" : [ 10125339 ], "children" : [ ] }, { "dbId" : 10122782, "stId" : "R-RNO-139887", "displayName" : "Vegfc [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "O35757", "standardIdentifier" : "uniprot:O35757", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Vegfc" ], "parents" : [ 10122784, 10123007 ], "children" : [ ] }, { "dbId" : 374400, "stId" : "R-RNO-374400", "displayName" : "Fyn [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49228 ], "identifier" : "Q62844", "standardIdentifier" : "uniprot:Q62844", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Fyn" ], "parents" : [ 10175192 ], "children" : [ ] }, { "dbId" : 451713, "stId" : "R-RNO-451713", "displayName" : "p110 beta [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q9Z1L0", "standardIdentifier" : "uniprot:Q9Z1L0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Pik3cb" ], "parents" : [ 10108621 ], "children" : [ ] }, { "dbId" : 10125341, "stId" : "R-RNO-192864", "displayName" : "HSP90AA1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49072, 49190 ], "identifier" : "P82995", "standardIdentifier" : "uniprot:P82995", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Hsp90aa1", "Hsp86", "Hspca" ], "parents" : [ 10125348, 10172402, 10175307, 10175206 ], "children" : [ ] }, { "dbId" : 10162706, "stId" : "R-RNO-372642", "displayName" : "Elmo2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "G3V982", "standardIdentifier" : "uniprot:G3V982", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Elmo2" ], "parents" : [ 10162708 ], "children" : [ ] }, { "dbId" : 10212881, "stId" : "R-RNO-9679453", "displayName" : "VEGFA-165 dimer:VEGFA inhibitors [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49308 ], "parents" : [ ], "children" : [ 10172375, 9679456 ] }, { "dbId" : 10162710, "stId" : "R-RNO-2029141", "displayName" : "CRK:DOCK180:ELMO1,ELMO2 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10175345 ], "children" : [ 10162708, 10117576, 10162698 ] }, { "dbId" : 10125335, "stId" : "R-RNO-202105", "displayName" : "eNOS:CaM:HSP90 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49194 ], "parents" : [ 10125339 ], "children" : [ 10125333, 10125312, 10125321 ] }, { "dbId" : 10176534, "stId" : "R-RNO-5357454", "displayName" : "VE-cadherin-Catenin complex [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49170 ], "parents" : [ ], "children" : [ 10136902, 10136834, 10136889, 10136906 ] }, { "dbId" : 10162708, "stId" : "R-RNO-372640", "displayName" : "ELMO1,ELMO2 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10162710 ], "children" : [ 10162706, 10162702 ] }, { "dbId" : 10125333, "stId" : "R-RNO-534996", "displayName" : "HSP90AA1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P82995", "standardIdentifier" : "uniprot:P82995", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Hsp90aa1", "Hsp86", "Hspca" ], "parents" : [ 10125358, 10125335 ], "children" : [ ] }, { "dbId" : 10162698, "stId" : "R-RNO-372654", "displayName" : "Ghost homologue of DOCK1 [cytosol]", "schemaClass" : "GenomeEncodedEntity", "speciesId" : 48895, "parents" : [ 10162710 ], "children" : [ ] }, { "dbId" : 10125323, "stId" : "R-RNO-202116", "displayName" : "eNOS:Caveolin-1:CaM [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49188 ], "parents" : [ ], "children" : [ 10125317, 10125321 ] }, { "dbId" : 112275, "stId" : "R-ALL-112275", "displayName" : "DAGs [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49286 ], "identifier" : "18035", "standardIdentifier" : "chebi:18035", "referenceType" : "ReferenceMolecule", "parents" : [ 10175228 ], "children" : [ ] }, { "dbId" : 179856, "stId" : "R-ALL-179856", "displayName" : "PI(4,5)P2 [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49144 ], "identifier" : "58456", "standardIdentifier" : "chebi:58456", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10125321, "stId" : "R-RNO-534997", "displayName" : "CALM1:4Ca2+ [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10125323, 10125358, 10125335 ], "children" : [ 10125319, 140648 ] }, { "dbId" : 10176527, "stId" : "R-RNO-5357487", "displayName" : "p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49163 ], "parents" : [ ], "children" : [ 10175362, 10134874 ] }, { "dbId" : 10162702, "stId" : "R-RNO-200932", "displayName" : "Elmo1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "D3ZY46", "standardIdentifier" : "uniprot:D3ZY46", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Elmo1" ], "parents" : [ 10162708 ], "children" : [ ] }, { "dbId" : 10176525, "stId" : "R-RNO-5357447", "displayName" : "2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49161 ], "parents" : [ ], "children" : [ 10175362, 10134872 ] }, { "dbId" : 10125315, "stId" : "R-RNO-534994", "displayName" : "Cav1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P41350", "standardIdentifier" : "uniprot:P41350", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Cav1", "Cav" ], "parents" : [ 10125317 ], "children" : [ ] }, { "dbId" : 10151424, "stId" : "R-RNO-1222707", "displayName" : "Ncf4 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A8I5ZNF3", "standardIdentifier" : "uniprot:A0A8I5ZNF3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Ncf4" ], "parents" : [ 10175320 ], "children" : [ ] }, { "dbId" : 10125312, "stId" : "R-RNO-203639", "displayName" : "palmitoylated, myristoylated eNOS dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10125317, 10125335 ], "children" : [ 29386, 73524, 10125310, 29426, 71185 ] }, { "dbId" : 10113031, "stId" : "R-RNO-57600", "displayName" : "ITGB3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q8R2H2", "standardIdentifier" : "uniprot:Q8R2H2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Itgb3" ], "parents" : [ 10127833 ], "children" : [ ] }, { "dbId" : 10176518, "stId" : "R-RNO-5357442", "displayName" : "VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:AXL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49134 ], "parents" : [ ], "children" : [ 10176516, 10173269 ] }, { "dbId" : 10125319, "stId" : "R-RNO-9016884", "displayName" : "CALM1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P0DP31", "standardIdentifier" : "uniprot:P0DP31", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10125321 ], "children" : [ ] }, { "dbId" : 10176516, "stId" : "R-RNO-197705", "displayName" : "AXL [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49133 ], "identifier" : "E9PSY0", "standardIdentifier" : "uniprot:E9PSY0", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10176518 ], "children" : [ ] }, { "dbId" : 10125317, "stId" : "R-RNO-202128", "displayName" : "eNOS:Caveolin-1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49186 ], "parents" : [ 10125323, 10125358 ], "children" : [ 10125312, 10125315 ] }, { "dbId" : 10122810, "stId" : "R-RNO-195393", "displayName" : "VEGFA,C,D dimers [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49029 ], "parents" : [ 10122818 ], "children" : [ 10122790, 10122784, 10122808 ] }, { "dbId" : 10122808, "stId" : "R-RNO-195364", "displayName" : "VEGFA dimer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49336 ], "parents" : [ 10122834, 10122810, 10123009 ], "children" : [ 10122806 ] }, { "dbId" : 10122814, "stId" : "R-RNO-195382", "displayName" : "VEGFR2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49030 ], "identifier" : "O08775", "standardIdentifier" : "uniprot:O08775", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10122816, 10173240 ], "children" : [ ] }, { "dbId" : 10122800, "stId" : "R-RNO-215140", "displayName" : "VEGFR3 dimer:VEGFC, VEGFD dimers [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49035 ], "parents" : [ ], "children" : [ 10122798, 10122792 ] }, { "dbId" : 29356, "stId" : "R-ALL-29356", "displayName" : "H2O [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49214 ], "identifier" : "15377", "standardIdentifier" : "chebi:15377", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10122806, "stId" : "R-RNO-2975974", "displayName" : "Vegfa [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P16612", "standardIdentifier" : "uniprot:P16612", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Vegfa" ], "parents" : [ 10123007, 10122808 ], "children" : [ ] }, { "dbId" : 29870, "stId" : "R-ALL-29870", "displayName" : "BH4 [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49204 ], "identifier" : "59560", "standardIdentifier" : "chebi:59560", "referenceType" : "ReferenceMolecule", "parents" : [ 10125353, 10125346 ], "children" : [ ] }, { "dbId" : 10122792, "stId" : "R-RNO-195391", "displayName" : "VEGFC,VEGFD dimers [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49034 ], "parents" : [ 10122800 ], "children" : [ 10122790, 10122784 ] }, { "dbId" : 10125353, "stId" : "R-RNO-1497830", "displayName" : "p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49205 ], "parents" : [ ], "children" : [ 10125348, 29870 ] }, { "dbId" : 29364, "stId" : "R-ALL-29364", "displayName" : "NADPH [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49207 ], "identifier" : "57783", "standardIdentifier" : "chebi:57783", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10125358, "stId" : "R-RNO-202130", "displayName" : "eNOS:Caveolin-1:CaM:HSP90 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49191 ], "parents" : [ ], "children" : [ 10125333, 10125317, 10125321 ] }, { "dbId" : 10122798, "stId" : "R-RNO-195405", "displayName" : "VEGFR3 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10122800 ], "children" : [ 10122796 ] }, { "dbId" : 29366, "stId" : "R-ALL-29366", "displayName" : "NADP+ [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49212 ], "identifier" : "58349", "standardIdentifier" : "chebi:58349", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10122796, "stId" : "R-RNO-195359", "displayName" : "FLT4 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49033 ], "identifier" : "Q91ZT1", "standardIdentifier" : "uniprot:Q91ZT1", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10122798 ], "children" : [ ] }, { "dbId" : 10125346, "stId" : "R-RNO-203564", "displayName" : "p-S1177-eNOS dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10125348 ], "children" : [ 29870, 29386, 10125344, 73524, 29426, 71185 ] }, { "dbId" : 29368, "stId" : "R-ALL-29368", "displayName" : "O2 [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49209 ], "identifier" : "15379", "standardIdentifier" : "chebi:15379", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 29370, "stId" : "R-ALL-29370", "displayName" : "ADP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49152, 49090, 49283, 49095, 49101, 49293, 49167, 49233, 49299, 49172, 49236, 49046, 49304, 49180, 49053, 49247, 49252, 49061, 49257, 49067, 49131, 49263, 49200, 49137, 49271, 49145, 49082, 49279 ], "identifier" : "456216", "standardIdentifier" : "chebi:456216", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10125344, "stId" : "R-RNO-202139", "displayName" : "phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q62600", "standardIdentifier" : "uniprot:Q62600", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10125346 ], "children" : [ ] }, { "dbId" : 10122784, "stId" : "R-RNO-195360", "displayName" : "VEGFC dimer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10122792, 10122810, 10123009 ], "children" : [ 10122782 ] }, { "dbId" : 10122790, "stId" : "R-RNO-195355", "displayName" : "VEGFD dimer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10122792, 10122810, 10123009 ], "children" : [ 10122788 ] }, { "dbId" : 10139175, "stId" : "R-RNO-430172", "displayName" : "VAV1,2,3 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10139858 ], "children" : [ 10127091, 10127087, 10127083 ] }, { "dbId" : 10125348, "stId" : "R-RNO-202121", "displayName" : "p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49201 ], "parents" : [ 10125353 ], "children" : [ 10112128, 10125346, 10125341, 10116556 ] }, { "dbId" : 10122788, "stId" : "R-RNO-139888", "displayName" : "Vegfd [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "O35251", "standardIdentifier" : "uniprot:O35251", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Vegfd" ], "parents" : [ 10122790, 10123007 ], "children" : [ ] }, { "dbId" : 10122843, "stId" : "R-RNO-195396", "displayName" : "VEGFR1 dimer:VEGFA, VEGFB, PGF dimers [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49027 ], "parents" : [ ], "children" : [ 10122834, 10122841 ] }, { "dbId" : 10122841, "stId" : "R-RNO-195398", "displayName" : "VEGFR1 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10122843, 10123028 ], "children" : [ 10122839 ] }, { "dbId" : 10120798, "stId" : "R-RNO-186833", "displayName" : "Rasa1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49298 ], "identifier" : "P50904", "standardIdentifier" : "uniprot:P50904", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Rasa1" ], "parents" : [ 10175353 ], "children" : [ ] }, { "dbId" : 10122834, "stId" : "R-RNO-195389", "displayName" : "VEGFA,VEGFB,PGF dimers [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49025 ], "parents" : [ 10122843 ], "children" : [ 10122832, 10122808, 10122826 ] }, { "dbId" : 29386, "stId" : "R-ALL-29386", "displayName" : "FAD [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "57692", "standardIdentifier" : "chebi:57692", "referenceType" : "ReferenceMolecule", "parents" : [ 10175318, 10125346, 10125312 ], "children" : [ ] }, { "dbId" : 10122832, "stId" : "R-RNO-195367", "displayName" : "VEGFB dimer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10122834, 10123009 ], "children" : [ 10122830 ] }, { "dbId" : 10135639, "stId" : "R-RNO-391821", "displayName" : "phospho-p-Y420-FYN [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q62844", "standardIdentifier" : "uniprot:Q62844", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Fyn" ], "parents" : [ 10175194 ], "children" : [ ] }, { "dbId" : 10122839, "stId" : "R-RNO-3004464", "displayName" : "VEGFR1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49026 ], "identifier" : "P53767", "standardIdentifier" : "uniprot:P53767", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10122841 ], "children" : [ ] }, { "dbId" : 10122826, "stId" : "R-RNO-195352", "displayName" : "PGF dimer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10122834, 10123009 ], "children" : [ 10122824 ] }, { "dbId" : 10122824, "stId" : "R-RNO-3009042", "displayName" : "Pgf [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q63434", "standardIdentifier" : "uniprot:Q63434", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Pgf" ], "parents" : [ 10122826, 10123007 ], "children" : [ ] }, { "dbId" : 10112073, "stId" : "R-RNO-57844", "displayName" : "PRKACA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P27791", "standardIdentifier" : "uniprot:P27791", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Prkaca" ], "parents" : [ 10175370 ], "children" : [ ] }, { "dbId" : 10122830, "stId" : "R-RNO-2975973", "displayName" : "Vegfb [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "O35485", "standardIdentifier" : "uniprot:O35485", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Vegfb" ], "parents" : [ 10122832, 10123007 ], "children" : [ ] }, { "dbId" : 10112079, "stId" : "R-RNO-57846", "displayName" : "PRKACB [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P68182", "standardIdentifier" : "uniprot:P68182", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Prkacb", "Pkacb" ], "parents" : [ 10175370 ], "children" : [ ] }, { "dbId" : 10122818, "stId" : "R-RNO-215139", "displayName" : "VEGFR2:VEGFA,C,D [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49031 ], "parents" : [ ], "children" : [ 10122816, 10122810 ] }, { "dbId" : 10125376, "stId" : "R-RNO-163510", "displayName" : "Cav1 [lipid droplet]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49193 ], "identifier" : "P41350", "standardIdentifier" : "uniprot:P41350", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Cav1", "Cav" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 10122816, "stId" : "R-RNO-195403", "displayName" : "VEGFR2 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10123020, 10122818 ], "children" : [ 10122814 ] }, { "dbId" : 10125381, "stId" : "R-RNO-202210", "displayName" : "PDPK1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49174 ], "identifier" : "O55173", "standardIdentifier" : "uniprot:O55173", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Pdpk1", "Pdk1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 9679475, "stId" : "R-ALL-9679475", "displayName" : "aflibercept [extracellular region]", "schemaClass" : "ProteinDrug", "speciesId" : 0, "identifier" : "6786", "standardIdentifier" : "iuphar.ligand:6786", "parents" : [ 9679456 ], "children" : [ ] }, { "dbId" : 10123386, "stId" : "R-RNO-2317310", "displayName" : "p-S-AKT:PIP3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49179 ], "parents" : [ 10165949 ], "children" : [ 179838, 10123384 ] }, { "dbId" : 9679474, "stId" : "R-ALL-9679474", "displayName" : "abicipar pegol [extracellular region]", "schemaClass" : "ProteinDrug", "speciesId" : 0, "identifier" : "8371", "standardIdentifier" : "iuphar.ligand:8371", "parents" : [ 9679456 ], "children" : [ ] }, { "dbId" : 10123384, "stId" : "R-RNO-2317317", "displayName" : "p-S-AKT [plasma membrane]", "schemaClass" : "CandidateSet", "speciesId" : 48895, "parents" : [ 10123386 ], "children" : [ 10123378, 10123380, 10123382 ] }, { "dbId" : 10123390, "stId" : "R-RNO-198632", "displayName" : "Rictor [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A8I5ZNG4", "standardIdentifier" : "uniprot:A0A8I5ZNG4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Rictor" ], "parents" : [ 10123407 ], "children" : [ ] }, { "dbId" : 29926, "stId" : "R-ALL-29926", "displayName" : "Mg2+ [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "18420", "standardIdentifier" : "chebi:18420", "referenceType" : "ReferenceMolecule", "parents" : [ 10120909, 10175141, 10171928 ], "children" : [ ] }, { "dbId" : 10138749, "stId" : "R-RNO-428933", "displayName" : "MAPK14 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P70618", "standardIdentifier" : "uniprot:P70618", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Mapk14", "Csbp1", "Csbp2" ], "parents" : [ 10175139 ], "children" : [ ] }, { "dbId" : 10123378, "stId" : "R-RNO-377265", "displayName" : "phospho-p-S473-AKT1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P47196", "standardIdentifier" : "uniprot:P47196", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Akt1" ], "parents" : [ 10123384 ], "children" : [ ] }, { "dbId" : 9679482, "stId" : "R-ALL-9679482", "displayName" : "brolucizumab [extracellular region]", "schemaClass" : "ProteinDrug", "speciesId" : 0, "identifier" : "8713", "standardIdentifier" : "iuphar.ligand:8713", "parents" : [ 9679456 ], "children" : [ ] }, { "dbId" : 10123376, "stId" : "R-RNO-2317329", "displayName" : "AKT:PIP3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49177 ], "parents" : [ 10123416 ], "children" : [ 179838, 10123374 ] }, { "dbId" : 29420, "stId" : "R-ALL-29420", "displayName" : "GDP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49110, 49158 ], "identifier" : "58189", "standardIdentifier" : "chebi:58189", "referenceType" : "ReferenceMolecule", "parents" : [ 9619813 ], "children" : [ ] }, { "dbId" : 10123382, "stId" : "R-RNO-3009363", "displayName" : "phospho-p-S472-AKT3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q63484", "standardIdentifier" : "uniprot:Q63484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Akt3" ], "parents" : [ 10123384 ], "children" : [ ] }, { "dbId" : 10123380, "stId" : "R-RNO-2317312", "displayName" : "phospho-p-S474-AKT2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P47197", "standardIdentifier" : "uniprot:P47197", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Akt2" ], "parents" : [ 10123384 ], "children" : [ ] }, { "dbId" : 10123370, "stId" : "R-RNO-202053", "displayName" : "AKT2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P47197", "standardIdentifier" : "uniprot:P47197", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Akt2" ], "parents" : [ 10123374 ], "children" : [ ] }, { "dbId" : 9679458, "stId" : "R-ALL-9679458", "displayName" : "bevacizumab [extracellular region]", "schemaClass" : "ProteinDrug", "speciesId" : 0, "identifier" : "6771", "standardIdentifier" : "iuphar.ligand:6771", "parents" : [ 9679456 ], "children" : [ ] }, { "dbId" : 10172009, "stId" : "R-RNO-3928564", "displayName" : "RHOA:GTP:ROCK1,ROCK2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49077 ], "parents" : [ ], "children" : [ 10112948, 10136946 ] }, { "dbId" : 10123368, "stId" : "R-RNO-199416", "displayName" : "AKT1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P47196", "standardIdentifier" : "uniprot:P47196", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Akt1" ], "parents" : [ 10123374 ], "children" : [ ] }, { "dbId" : 29426, "stId" : "R-ALL-29426", "displayName" : "Zn2+ [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "29105", "standardIdentifier" : "chebi:29105", "referenceType" : "ReferenceMolecule", "parents" : [ 10125346, 10125312 ], "children" : [ ] }, { "dbId" : 9679456, "stId" : "R-ALL-9679456", "displayName" : "VEGFA inhibitors [extracellular region]", "schemaClass" : "CandidateSet", "speciesId" : 0, "diagramIds" : [ 49310 ], "parents" : [ 10212881 ], "children" : [ 9679464, 9679482, 9679463, 9679458, 9679475, 9679469, 9679474 ] }, { "dbId" : 9679463, "stId" : "R-ALL-9679463", "displayName" : "pegaptanib [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "identifier" : "6836", "standardIdentifier" : "iuphar.ligand:6836", "parents" : [ 9679456 ], "children" : [ ] }, { "dbId" : 10123374, "stId" : "R-RNO-202052", "displayName" : "AKT [plasma membrane]", "schemaClass" : "CandidateSet", "speciesId" : 48895, "parents" : [ 10123376 ], "children" : [ 10123368, 10123372, 10123370 ] }, { "dbId" : 10123372, "stId" : "R-RNO-2976006", "displayName" : "AKT3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q63484", "standardIdentifier" : "uniprot:Q63484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Akt3" ], "parents" : [ 10123374 ], "children" : [ ] }, { "dbId" : 9679464, "stId" : "R-ALL-9679464", "displayName" : "ranibizumab [extracellular region]", "schemaClass" : "ProteinDrug", "speciesId" : 0, "identifier" : "6779", "standardIdentifier" : "iuphar.ligand:6779", "parents" : [ 9679456 ], "children" : [ ] }, { "dbId" : 10130022, "stId" : "R-RNO-354068", "displayName" : "phospho-p-Y397-PTK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "O35346", "standardIdentifier" : "uniprot:O35346", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Ptk2", "Fak", "Fak1" ], "parents" : [ 10175125 ], "children" : [ ] }, { "dbId" : 9679469, "stId" : "R-ALL-9679469", "displayName" : "vanucizumab [extracellular region]", "schemaClass" : "ProteinDrug", "speciesId" : 0, "identifier" : "9132", "standardIdentifier" : "iuphar.ligand:9132", "parents" : [ 9679456 ], "children" : [ ] }, { "dbId" : 29438, "stId" : "R-ALL-29438", "displayName" : "GTP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49156, 49108 ], "identifier" : "37565", "standardIdentifier" : "chebi:37565", "referenceType" : "ReferenceMolecule", "parents" : [ 10171928, 10120616, 10112948, 10118107, 9628560 ], "children" : [ ] }, { "dbId" : 9628560, "stId" : "R-RNO-9628560", "displayName" : "Rac1:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49218, 49111 ], "parents" : [ 10162613, 10175362, 10175322 ], "children" : [ 205143, 29438 ] }, { "dbId" : 10175390, "stId" : "R-RNO-5218769", "displayName" : "HSP27 oligomer:F-actin [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49260 ], "parents" : [ ], "children" : [ 10135745, 10175388 ] }, { "dbId" : 10162589, "stId" : "R-RNO-200965", "displayName" : "Wasf1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q5BJU7", "standardIdentifier" : "uniprot:Q5BJU7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Wasf1" ], "parents" : [ 10162595 ], "children" : [ ] }, { "dbId" : 10175388, "stId" : "R-RNO-5218689", "displayName" : "HSBP1 oligomer [cytosol]", "schemaClass" : "Polymer", "speciesId" : 48895, "parents" : [ 10175390 ], "children" : [ 10141845 ] }, { "dbId" : 10162578, "stId" : "R-RNO-1671649", "displayName" : "ABI [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48895, "parents" : [ 10162611 ], "children" : [ 10162572, 10162576 ] }, { "dbId" : 10162576, "stId" : "R-RNO-1671647", "displayName" : "Abi2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A8I5ZLD3", "standardIdentifier" : "uniprot:A0A8I5ZLD3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Abi2" ], "parents" : [ 10162578 ], "children" : [ ] }, { "dbId" : 10162582, "stId" : "R-RNO-200972", "displayName" : "Wasf2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q5FWU0", "standardIdentifier" : "uniprot:Q5FWU0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Wasf2" ], "parents" : [ 10162595 ], "children" : [ ] }, { "dbId" : 10135444, "stId" : "R-RNO-391267", "displayName" : "SPHK1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49291 ], "identifier" : "Q91V26", "standardIdentifier" : "uniprot:Q91V26", "referenceType" : "ReferenceGeneProduct", "parents" : [ ], "children" : [ ] }, { "dbId" : 29968, "stId" : "R-ALL-29968", "displayName" : "L-Cit [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49213 ], "identifier" : "57743", "standardIdentifier" : "chebi:57743", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10175370, "stId" : "R-RNO-425833", "displayName" : "Protein kinase A catalytic subunit [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48895, "diagramIds" : [ 49238 ], "parents" : [ ], "children" : [ 10112079, 10112073 ] }, { "dbId" : 10162568, "stId" : "R-RNO-1671645", "displayName" : "Brk1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "D3ZUP5", "standardIdentifier" : "uniprot:D3ZUP5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Brk1" ], "parents" : [ 10162611 ], "children" : [ ] }, { "dbId" : 10162572, "stId" : "R-RNO-1671643", "displayName" : "Abi1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q9QZM5", "standardIdentifier" : "uniprot:Q9QZM5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Abi1" ], "parents" : [ 10162578 ], "children" : [ ] }, { "dbId" : 10175362, "stId" : "R-RNO-5218784", "displayName" : "p-VAV family:PIP3:RAC1:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49157 ], "parents" : [ 10176525, 10176527 ], "children" : [ 10175262, 9628560 ] }, { "dbId" : 10162560, "stId" : "R-RNO-442574", "displayName" : "Baiap2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49114 ], "identifier" : "Q6GMN2", "standardIdentifier" : "uniprot:Q6GMN2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Baiap2" ], "parents" : [ 10162613 ], "children" : [ ] }, { "dbId" : 10175360, "stId" : "R-RNO-8951587", "displayName" : "p-VAV family:PIP3:RAC1:GDP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49155 ], "parents" : [ ], "children" : [ 9619813, 10175262 ] }, { "dbId" : 29468, "stId" : "R-ALL-29468", "displayName" : "L-Arg [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49208 ], "identifier" : "32682", "standardIdentifier" : "chebi:32682", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10162564, "stId" : "R-RNO-200979", "displayName" : "Nckap1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P55161", "standardIdentifier" : "uniprot:P55161", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Nckap1" ], "parents" : [ 10162611 ], "children" : [ ] }, { "dbId" : 74016, "stId" : "R-ALL-74016", "displayName" : "Ca2+ [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49287 ], "identifier" : "29108", "standardIdentifier" : "chebi:29108", "referenceType" : "ReferenceMolecule", "parents" : [ 10175228, 10112128 ], "children" : [ ] }, { "dbId" : 10162611, "stId" : "R-RNO-2029154", "displayName" : "WAVE Regulatory Complex [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49115 ], "parents" : [ 10162613 ], "children" : [ 10162564, 10162609, 10162578, 10162595, 10162605, 10162568 ] }, { "dbId" : 10112944, "stId" : "R-RNO-194510", "displayName" : "RHOA [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P61589", "standardIdentifier" : "uniprot:P61589", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10112948 ], "children" : [ ] }, { "dbId" : 10162609, "stId" : "R-RNO-5694031", "displayName" : "Nckap1l [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A0G2JUF9", "standardIdentifier" : "uniprot:A0A0G2JUF9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Nckap1l" ], "parents" : [ 10162611 ], "children" : [ ] }, { "dbId" : 10112948, "stId" : "R-RNO-5665993", "displayName" : "RHOA:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49075 ], "parents" : [ 10172009 ], "children" : [ 29438, 10112944 ] }, { "dbId" : 10162613, "stId" : "R-RNO-2029147", "displayName" : "WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49117 ], "parents" : [ ], "children" : [ 179838, 10162560, 10162611, 9628560 ] }, { "dbId" : 10162603, "stId" : "R-RNO-1671642", "displayName" : "Cyfip2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A0G2JT63", "standardIdentifier" : "uniprot:A0A0G2JT63", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Cyfip2" ], "parents" : [ 10162605 ], "children" : [ ] }, { "dbId" : 10120616, "stId" : "R-RNO-182921", "displayName" : "CDC42:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49243 ], "parents" : [ 10175155, 10175221, 10175232 ], "children" : [ 29438, 10120614 ] }, { "dbId" : 73524, "stId" : "R-ALL-73524", "displayName" : "FMN [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "58210", "standardIdentifier" : "chebi:58210", "referenceType" : "ReferenceMolecule", "parents" : [ 10125346, 10125312 ], "children" : [ ] }, { "dbId" : 10162605, "stId" : "R-RNO-5672576", "displayName" : "CYFIP1,CYFIP2 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10162611 ], "children" : [ 10162599, 10162603 ] }, { "dbId" : 10175395, "stId" : "R-RNO-5218697", "displayName" : "phospho-Hspb1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49262 ], "identifier" : "P42930", "standardIdentifier" : "uniprot:P42930", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Hspb1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 10162595, "stId" : "R-RNO-2029114", "displayName" : "WAVEs [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48895, "parents" : [ 10162611 ], "children" : [ 10162582, 10162593, 10162589 ] }, { "dbId" : 10162593, "stId" : "R-RNO-200975", "displayName" : "Wasf3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "M0R7F3", "standardIdentifier" : "uniprot:M0R7F3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Wasf3" ], "parents" : [ 10162595 ], "children" : [ ] }, { "dbId" : 10120614, "stId" : "R-RNO-449545", "displayName" : "CDC42 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q8CFN2", "standardIdentifier" : "uniprot:Q8CFN2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Cdc42" ], "parents" : [ 10120616 ], "children" : [ ] }, { "dbId" : 10162599, "stId" : "R-RNO-5672575", "displayName" : "Cyfip1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "D4A8H8", "standardIdentifier" : "uniprot:D4A8H8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Cyfip1" ], "parents" : [ 10162605 ], "children" : [ ] }, { "dbId" : 10118107, "stId" : "R-RNO-109783", "displayName" : "p21 RAS:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49300 ], "parents" : [ 10175353 ], "children" : [ 10118105, 29438 ] }, { "dbId" : 10130392, "stId" : "R-RNO-197954", "displayName" : "Nck1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "B2RZ33", "standardIdentifier" : "uniprot:B2RZ33", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Nck1" ], "parents" : [ 10130417 ], "children" : [ ] }, { "dbId" : 10127833, "stId" : "R-RNO-210216", "displayName" : "Integrin alphaVbeta3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49069 ], "parents" : [ 10175241 ], "children" : [ 10127831, 10113031 ] }, { "dbId" : 10118105, "stId" : "R-RNO-9649715", "displayName" : "mature p21 RAS [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10118107 ], "children" : [ 10118100, 10118103, 10118086, 10118094 ] }, { "dbId" : 10172383, "stId" : "R-RNO-4420103", "displayName" : "phospho-p-6Y-VEGFR2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "O08775", "standardIdentifier" : "uniprot:O08775", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10172385 ], "children" : [ ] }, { "dbId" : 10172375, "stId" : "R-RNO-4420158", "displayName" : "VEGFA-165 dimer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49307 ], "parents" : [ 10212881, 10173240, 10172387 ], "children" : [ 10172373 ] }, { "dbId" : 10127831, "stId" : "R-RNO-210013", "displayName" : "Itgav [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "F1LZX9", "standardIdentifier" : "uniprot:F1LZX9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10127833 ], "children" : [ ] }, { "dbId" : 10118103, "stId" : "R-RNO-9647815", "displayName" : "S-Farn-Me KRAS4B [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P08644", "standardIdentifier" : "uniprot:P08644", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Kras", "Kras2" ], "parents" : [ 10118105 ], "children" : [ ] }, { "dbId" : 10172373, "stId" : "R-RNO-4420127", "displayName" : "Vegfa [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P16612", "standardIdentifier" : "uniprot:P16612", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Vegfa" ], "parents" : [ 10172375 ], "children" : [ ] }, { "dbId" : 10118100, "stId" : "R-RNO-9647912", "displayName" : "S-Farn-Me-2xPalmS HRAS [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P20171", "standardIdentifier" : "uniprot:P20171", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Hras", "Hras1" ], "parents" : [ 10118105 ], "children" : [ ] }, { "dbId" : 10117576, "stId" : "R-RNO-2980677", "displayName" : "Crk [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49105 ], "identifier" : "Q63768", "standardIdentifier" : "uniprot:Q63768", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Crk", "Crko" ], "parents" : [ 10175291, 10162710 ], "children" : [ ] }, { "dbId" : 205143, "stId" : "R-RNO-205143", "displayName" : "Rac1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q6RUV5", "standardIdentifier" : "uniprot:Q6RUV5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Rac1", "Rac" ], "parents" : [ 9619813, 9628560 ], "children" : [ ] }, { "dbId" : 3299686, "stId" : "R-ALL-3299686", "displayName" : "O2.- [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49222 ], "identifier" : "18421", "standardIdentifier" : "chebi:18421", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10118094, "stId" : "R-RNO-9647910", "displayName" : "S-Farn-Me PalmS NRAS [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q04970", "standardIdentifier" : "uniprot:Q04970", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Nras" ], "parents" : [ 10118105 ], "children" : [ ] }, { "dbId" : 10116556, "stId" : "R-RNO-198356", "displayName" : "phospho-p-T308,S473-AKT1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49196 ], "identifier" : "P47196", "standardIdentifier" : "uniprot:P47196", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Akt1" ], "parents" : [ 10125348 ], "children" : [ ] }, { "dbId" : 10118086, "stId" : "R-RNO-9647915", "displayName" : "S-Farn-Me-PalmS KRAS4A [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P08644", "standardIdentifier" : "uniprot:P08644", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Kras", "Kras2" ], "parents" : [ 10118105 ], "children" : [ ] }, { "dbId" : 10151416, "stId" : "R-RNO-1222296", "displayName" : "Ncf1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "F1M707", "standardIdentifier" : "uniprot:F1M707", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Ncf1" ], "parents" : [ 10175320 ], "children" : [ ] }, { "dbId" : 10125310, "stId" : "R-RNO-534993", "displayName" : "2xPalmC-MyrG-NOS3 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q62600", "standardIdentifier" : "uniprot:Q62600", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10125312 ], "children" : [ ] }, { "dbId" : 10151420, "stId" : "R-RNO-1222600", "displayName" : "Ncf2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A7E3N2", "standardIdentifier" : "uniprot:A7E3N2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Ncf2" ], "parents" : [ 10175320 ], "children" : [ ] }, { "dbId" : 10172402, "stId" : "R-RNO-5218637", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1:HSP90AA1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49073 ], "parents" : [ ], "children" : [ 10172400, 10125341 ] }, { "dbId" : 140648, "stId" : "R-ALL-140648", "displayName" : "Ca2+ [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "29108", "standardIdentifier" : "chebi:29108", "referenceType" : "ReferenceMolecule", "parents" : [ 10125321 ], "children" : [ ] }, { "dbId" : 10130417, "stId" : "R-RNO-381949", "displayName" : "NCK1,NCK2 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49225 ], "parents" : [ 10175143 ], "children" : [ 10130415, 10130392 ] }, { "dbId" : 10172400, "stId" : "R-RNO-5218636", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2:SRC-1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49066 ], "parents" : [ 10172402 ], "children" : [ 548926, 10172398 ] }, { "dbId" : 10116593, "stId" : "R-RNO-165676", "displayName" : "Mlst8 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q9Z2K5", "standardIdentifier" : "uniprot:Q9Z2K5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Mlst8" ], "parents" : [ 10123407 ], "children" : [ ] }, { "dbId" : 10116597, "stId" : "R-RNO-165662", "displayName" : "MTOR [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P42346", "standardIdentifier" : "uniprot:P42346", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10123407 ], "children" : [ ] }, { "dbId" : 10172394, "stId" : "R-RNO-4420164", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:p-S-SHB [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49052 ], "parents" : [ 10172398, 10173219, 10175125, 10175305, 10175204 ], "children" : [ 10172387, 10172392 ] }, { "dbId" : 10172392, "stId" : "R-RNO-5228991", "displayName" : "phospho-Shb [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "D3ZN31", "standardIdentifier" : "uniprot:D3ZN31", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Shb" ], "parents" : [ 10172394 ], "children" : [ ] }, { "dbId" : 10130415, "stId" : "R-RNO-204885", "displayName" : "Nck2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "D4A3M8", "standardIdentifier" : "uniprot:D4A3M8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Nck2" ], "parents" : [ 10130417 ], "children" : [ ] }, { "dbId" : 10172398, "stId" : "R-RNO-5218635", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:p-5Y-PTK2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10172400 ], "children" : [ 10172396, 10172394 ] }, { "dbId" : 10172396, "stId" : "R-RNO-5218711", "displayName" : "phospho-p-5Y-PTK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "O35346", "standardIdentifier" : "uniprot:O35346", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Ptk2", "Fak", "Fak1" ], "parents" : [ 10172398 ], "children" : [ ] }, { "dbId" : 10172387, "stId" : "R-RNO-4420101", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49120, 49045 ], "parents" : [ 10173236, 10175143, 10173225, 10175241, 10172394, 10173257, 10175245, 10173245, 10173247 ], "children" : [ 10172375, 10172385 ] }, { "dbId" : 10172385, "stId" : "R-RNO-4420096", "displayName" : "p-6Y-VEGFR2 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10172387 ], "children" : [ 10172383 ] }, { "dbId" : 10112998, "stId" : "R-RNO-58198", "displayName" : "PRKCB [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P68403", "standardIdentifier" : "uniprot:P68403", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175268 ], "children" : [ ] }, { "dbId" : 10175257, "stId" : "R-RNO-5357488", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49147 ], "parents" : [ ], "children" : [ 10175255, 10175245 ] }, { "dbId" : 10175262, "stId" : "R-RNO-5218789", "displayName" : "p-VAV family:PIP3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49151 ], "parents" : [ 10175362, 10175360 ], "children" : [ 179838, 10162511 ] }, { "dbId" : 10175251, "stId" : "R-RNO-5357460", "displayName" : "phospho-p-Y779,Y821-AXL [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "E9PSY0", "standardIdentifier" : "uniprot:E9PSY0", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175253 ], "children" : [ ] }, { "dbId" : 10123026, "stId" : "R-RNO-549042", "displayName" : "NRP2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49040 ], "identifier" : "O35276", "standardIdentifier" : "uniprot:O35276", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10123028 ], "children" : [ ] }, { "dbId" : 10175255, "stId" : "R-RNO-5357453", "displayName" : "VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49141 ], "parents" : [ 10175257 ], "children" : [ 10175253, 10108623 ] }, { "dbId" : 10175253, "stId" : "R-RNO-5357462", "displayName" : "VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49138 ], "parents" : [ 10175255 ], "children" : [ 10173269, 10175251 ] }, { "dbId" : 10123028, "stId" : "R-RNO-195427", "displayName" : "NRP2:VEGFR1 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49041 ], "parents" : [ ], "children" : [ 10123026, 10122841 ] }, { "dbId" : 10225427, "stId" : "R-RNO-9833482", "displayName" : "PKR-mediated signaling", "schemaClass" : "Pathway", "speciesId" : 48895, "diagramIds" : [ 49337 ] }, { "dbId" : 202124, "stId" : "R-ALL-202124", "displayName" : "NO [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49211 ], "identifier" : "16480", "standardIdentifier" : "chebi:16480", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10152202, "stId" : "R-RNO-171012", "displayName" : "MAPK13 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q9WTY9", "standardIdentifier" : "uniprot:Q9WTY9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175139 ], "children" : [ ] }, { "dbId" : 10123018, "stId" : "R-RNO-3008773", "displayName" : "NRP1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49037 ], "identifier" : "Q9QWJ9", "standardIdentifier" : "uniprot:Q9QWJ9", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10123020 ], "children" : [ ] }, { "dbId" : 10175241, "stId" : "R-RNO-5218779", "displayName" : "VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49070 ], "parents" : [ 10175328, 10175333 ], "children" : [ 10172387, 10127833 ] }, { "dbId" : 10152204, "stId" : "R-RNO-171025", "displayName" : "MAPK12 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q63538", "standardIdentifier" : "uniprot:Q63538", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175139 ], "children" : [ ] }, { "dbId" : 10175245, "stId" : "R-RNO-5218777", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49316 ], "parents" : [ 10175257 ], "children" : [ 10172387, 10108623 ] }, { "dbId" : 10123020, "stId" : "R-RNO-195419", "displayName" : "NRP1:VEGFR2 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49038 ], "parents" : [ ], "children" : [ 10122816, 10123018 ] }, { "dbId" : 10136834, "stId" : "R-RNO-418992", "displayName" : "VE-cadherin [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A0G2K0I6", "standardIdentifier" : "uniprot:A0A0G2K0I6", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10176534 ], "children" : [ ] }, { "dbId" : 10175234, "stId" : "R-RNO-5218782", "displayName" : "VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:PAK2:CDC42:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49244 ], "parents" : [ ], "children" : [ 10175232, 10175148 ] }, { "dbId" : 10175232, "stId" : "R-RNO-5218770", "displayName" : "PAK2 dimer:CDC42:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10175234 ], "children" : [ 10134861, 10120616 ] }, { "dbId" : 10123009, "stId" : "R-RNO-195376", "displayName" : "VEGF dimer [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49023 ], "parents" : [ ], "children" : [ 10122790, 10122784, 10122832, 10122808, 10122826 ] }, { "dbId" : 10152198, "stId" : "R-RNO-170989", "displayName" : "MAPK11 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A0G2KB06", "standardIdentifier" : "uniprot:A0A0G2KB06", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175139 ], "children" : [ ] }, { "dbId" : 10175291, "stId" : "R-RNO-5218765", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49106 ], "parents" : [ ], "children" : [ 10175289, 10117576 ] }, { "dbId" : 10136891, "stId" : "R-RNO-9038440", "displayName" : "Ctnnb1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q9WU82", "standardIdentifier" : "uniprot:Q9WU82", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Ctnnb1" ], "parents" : [ 10136893 ], "children" : [ ] }, { "dbId" : 10175289, "stId" : "R-RNO-5218759", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49104 ], "parents" : [ 10175291, 10175345 ], "children" : [ 10175287, 10175214 ] }, { "dbId" : 10173240, "stId" : "R-RNO-195402", "displayName" : "VEGFA-165 dimer:VEGFR2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49043 ], "parents" : [ ], "children" : [ 10172375, 10122814 ] }, { "dbId" : 10136889, "stId" : "R-RNO-191735", "displayName" : "Ctnna1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q5U302", "standardIdentifier" : "uniprot:Q5U302", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Ctnna1" ], "parents" : [ 10176539, 10176534 ], "children" : [ ] }, { "dbId" : 10173247, "stId" : "R-RNO-4420110", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49270 ], "parents" : [ ], "children" : [ 10172387, 10125656 ] }, { "dbId" : 10173245, "stId" : "R-RNO-4420203", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49267 ], "parents" : [ ], "children" : [ 10172387, 10125512 ] }, { "dbId" : 10136893, "stId" : "R-RNO-191731", "displayName" : "beta-catenin [plasma membrane]", "schemaClass" : "CandidateSet", "speciesId" : 48895, "parents" : [ 10136902 ], "children" : [ 10136891 ] }, { "dbId" : 10173234, "stId" : "R-RNO-167050", "displayName" : "Shc2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49119 ], "identifier" : "O70142", "standardIdentifier" : "uniprot:O70142", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Shc2" ], "parents" : [ 10173236 ], "children" : [ ] }, { "dbId" : 10175287, "stId" : "R-RNO-5218762", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49315 ], "parents" : [ 10175289 ], "children" : [ 10175285, 10175206 ] }, { "dbId" : 10175285, "stId" : "R-RNO-5218739", "displayName" : "phospho-Bcar1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q63767", "standardIdentifier" : "uniprot:Q63767", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Bcar1" ], "parents" : [ 10175287 ], "children" : [ ] }, { "dbId" : 10173236, "stId" : "R-RNO-4420171", "displayName" : "VEGFA:p-6Y-VEGFR2:SHC2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49121 ], "parents" : [ ], "children" : [ 10173234, 10172387 ] }, { "dbId" : 10173225, "stId" : "R-RNO-4420196", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:SHB [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49049 ], "parents" : [ ], "children" : [ 10173223, 10172387 ] }, { "dbId" : 10173219, "stId" : "R-RNO-4420141", "displayName" : "VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49057 ], "parents" : [ ], "children" : [ 10125042, 10172394 ] }, { "dbId" : 113592, "stId" : "R-ALL-113592", "displayName" : "ATP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49088, 49282, 49093, 49290, 49100, 49165, 49295, 49231, 49169, 49235, 49044, 49303, 49178, 49051, 49246, 49250, 49059, 49254, 49065, 49129, 49259, 49199, 49136, 49269, 49143, 49081, 49276, 49150 ], "identifier" : "30616", "standardIdentifier" : "chebi:30616", "referenceType" : "ReferenceMolecule", "parents" : [ 10126040 ], "children" : [ ] }, { "dbId" : 10175266, "stId" : "R-RNO-58218", "displayName" : "PRKCZ [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P09217", "standardIdentifier" : "uniprot:P09217", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Prkcz", "Pkcz" ], "parents" : [ 10175268 ], "children" : [ ] }, { "dbId" : 10173223, "stId" : "R-RNO-4420213", "displayName" : "Shb [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49048 ], "identifier" : "D3ZN31", "standardIdentifier" : "uniprot:D3ZN31", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Shb" ], "parents" : [ 10173225 ], "children" : [ ] }, { "dbId" : 10175268, "stId" : "R-RNO-5218761", "displayName" : "PKCA,PKCB,PKCD,PKCZ [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49277 ], "parents" : [ ], "children" : [ 10112196, 10112199, 10112998, 10175266 ] }, { "dbId" : 10134874, "stId" : "R-RNO-390765", "displayName" : "PAK1,2,3 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10176527 ], "children" : [ 10134868, 10134850, 10134859 ] }, { "dbId" : 10175322, "stId" : "R-RNO-5218774", "displayName" : "NOX2 complex:RAC1:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49219 ], "parents" : [ ], "children" : [ 10175320, 9628560 ] }, { "dbId" : 10125656, "stId" : "R-RNO-167679", "displayName" : "phospho-p-4Y-PLCG1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49274 ], "identifier" : "P10686", "standardIdentifier" : "uniprot:P10686", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Plcg1" ], "parents" : [ 10173247 ], "children" : [ ] }, { "dbId" : 10134872, "stId" : "R-RNO-399856", "displayName" : "PAK1,2,3 dimer [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49160 ], "parents" : [ 10176525 ], "children" : [ 10134852, 10134870, 10134861 ] }, { "dbId" : 10175320, "stId" : "R-RNO-5218791", "displayName" : "NOX2 complex [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49217 ], "parents" : [ 10175322 ], "children" : [ 10175318, 10151424, 10151420, 10151416 ] }, { "dbId" : 10175314, "stId" : "R-RNO-5218744", "displayName" : "Cyba [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q62737", "standardIdentifier" : "uniprot:Q62737", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Cyba" ], "parents" : [ 10175318 ], "children" : [ ] }, { "dbId" : 1606609, "stId" : "R-ALL-1606609", "displayName" : "SPG [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "84410", "standardIdentifier" : "chebi:84410", "referenceType" : "ReferenceMolecule", "parents" : [ 10175353 ], "children" : [ ] }, { "dbId" : 10135376, "stId" : "R-RNO-390932", "displayName" : "PTK2B [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49085 ], "identifier" : "P70600", "standardIdentifier" : "uniprot:P70600", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175328 ], "children" : [ ] }, { "dbId" : 10134870, "stId" : "R-RNO-5669154", "displayName" : "PAK3 dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10134872 ], "children" : [ 10134868 ] }, { "dbId" : 10175318, "stId" : "R-RNO-5218783", "displayName" : "Cytochrome b-245 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10175320 ], "children" : [ 10175316, 29386, 10175314, 71185 ] }, { "dbId" : 10173269, "stId" : "R-RNO-5218788", "displayName" : "VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49130 ], "parents" : [ 10176518, 10175253 ], "children" : [ 10130052, 10173257 ] }, { "dbId" : 10134868, "stId" : "R-RNO-428457", "displayName" : "PAK3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q62829", "standardIdentifier" : "uniprot:Q62829", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10134874, 10134870 ], "children" : [ ] }, { "dbId" : 10175316, "stId" : "R-RNO-5218720", "displayName" : "Cybb [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q9ERL1", "standardIdentifier" : "uniprot:Q9ERL1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Cybb" ], "parents" : [ 10175318 ], "children" : [ ] }, { "dbId" : 5218688, "stId" : "R-ALL-5218688", "displayName" : "S1P [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49297 ], "identifier" : "60119", "standardIdentifier" : "chebi:60119", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10173259, "stId" : "R-RNO-4420169", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49127 ], "parents" : [ ], "children" : [ 548926, 10173257 ] }, { "dbId" : 10175307, "stId" : "R-RNO-5218775", "displayName" : "VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2:SRC-1:HSP90AA1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49083 ], "parents" : [ ], "children" : [ 10125341, 548926, 10175305 ] }, { "dbId" : 10136906, "stId" : "R-RNO-418996", "displayName" : "Ctnnd1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "A0A0G2JXM1", "standardIdentifier" : "uniprot:A0A0G2JXM1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Ctnnd1" ], "parents" : [ 10176539, 10176534 ], "children" : [ ] }, { "dbId" : 10134859, "stId" : "R-RNO-211604", "displayName" : "PAK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q64303", "standardIdentifier" : "uniprot:Q64303", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10134874, 10134861 ], "children" : [ ] }, { "dbId" : 10173257, "stId" : "R-RNO-4420137", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49124 ], "parents" : [ 10173259, 10173269 ], "children" : [ 10173255, 10172387 ] }, { "dbId" : 10175305, "stId" : "R-RNO-5218771", "displayName" : "VEGFA:p-6Y-VEGFR2:pS-SHB:p-5Y,S732-PTK2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10175307 ], "children" : [ 10175303, 10172394 ] }, { "dbId" : 10111304, "stId" : "R-RNO-109697", "displayName" : "PDPK1:PIP3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49175 ], "parents" : [ 10165949 ], "children" : [ 179838, 10111302 ] }, { "dbId" : 10162511, "stId" : "R-RNO-2029115", "displayName" : "p-VAV family [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10175262 ], "children" : [ 10139873, 10139885, 10139851 ] }, { "dbId" : 10175309, "stId" : "R-RNO-5228987", "displayName" : "RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49079 ], "parents" : [ ], "children" : [ 10136946, 10171928 ] }, { "dbId" : 10134861, "stId" : "R-RNO-2685645", "displayName" : "PAK2 dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49240 ], "parents" : [ 10175232, 10175337, 10134872 ], "children" : [ 10134859 ] }, { "dbId" : 10134850, "stId" : "R-RNO-162629", "displayName" : "PAK1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P35465", "standardIdentifier" : "uniprot:P35465", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10134874, 10134852 ], "children" : [ ] }, { "dbId" : 70106, "stId" : "R-ALL-70106", "displayName" : "H+ [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49202, 49223, 49210 ], "identifier" : "15378", "standardIdentifier" : "chebi:15378", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10175296, "stId" : "R-RNO-5218716", "displayName" : "phospho-p-S225-SPHK1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49292 ], "identifier" : "Q91V26", "standardIdentifier" : "uniprot:Q91V26", "referenceType" : "ReferenceGeneProduct", "parents" : [ ], "children" : [ ] }, { "dbId" : 10173255, "stId" : "R-RNO-4420125", "displayName" : "Sh2d2a [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49123 ], "identifier" : "Q5I0Q2", "standardIdentifier" : "uniprot:Q5I0Q2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Sh2d2a" ], "parents" : [ 10173257 ], "children" : [ ] }, { "dbId" : 10175303, "stId" : "R-RNO-5229006", "displayName" : "phospho-p-5Y,S732-PTK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "O35346", "standardIdentifier" : "uniprot:O35346", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Ptk2", "Fak", "Fak1" ], "parents" : [ 10175305 ], "children" : [ ] }, { "dbId" : 10111302, "stId" : "R-RNO-61459", "displayName" : "PDPK1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "diagramIds" : [ 49280 ], "identifier" : "O55173", "standardIdentifier" : "uniprot:O55173", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Pdpk1", "Pdk1" ], "parents" : [ 10111304 ], "children" : [ ] }, { "dbId" : 10136902, "stId" : "R-RNO-418993", "displayName" : "Beta-catenin/gamma catenin [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "parents" : [ 10176539, 10176534 ], "children" : [ 10136900, 10136893 ] }, { "dbId" : 10136900, "stId" : "R-RNO-437260", "displayName" : "Jup [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q6P0K8", "standardIdentifier" : "uniprot:Q6P0K8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "Jup" ], "parents" : [ 10136902 ], "children" : [ ] }, { "dbId" : 10134852, "stId" : "R-RNO-445002", "displayName" : "PAK1 dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48895, "parents" : [ 10134872 ], "children" : [ 10134850 ] }, { "dbId" : 10175353, "stId" : "R-RNO-5218802", "displayName" : "RASA1:p21 RAS:GTP:SPG [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49296 ], "parents" : [ ], "children" : [ 1606609, 10120798, 10118107 ] }, { "dbId" : 10136946, "stId" : "R-RNO-419057", "displayName" : "ROCK1,ROCK2 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49076 ], "parents" : [ 10172009, 10175309 ], "children" : [ 10136944, 10124974 ] }, { "dbId" : 5693375, "stId" : "R-ALL-5693375", "displayName" : "ADMA [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 49215 ], "identifier" : "58326", "standardIdentifier" : "chebi:58326", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 10136944, "stId" : "R-RNO-419058", "displayName" : "ROCK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q62868", "standardIdentifier" : "uniprot:Q62868", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10136946 ], "children" : [ ] }, { "dbId" : 10175345, "stId" : "R-RNO-5218776", "displayName" : "CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49112 ], "parents" : [ ], "children" : [ 10162710, 10175289 ] }, { "dbId" : 10135921, "stId" : "R-RNO-399824", "displayName" : "phospho-p-S141,T402-PAK2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q64303", "standardIdentifier" : "uniprot:Q64303", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175219, 10135927 ], "children" : [ ] }, { "dbId" : 10135927, "stId" : "R-RNO-399836", "displayName" : "p-S,T-PAK1,2,3 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48895, "diagramIds" : [ 49166 ], "parents" : [ ], "children" : [ 10135925, 10135921, 10135917 ] }, { "dbId" : 10135925, "stId" : "R-RNO-5357471", "displayName" : "phospho-p-S154,T436-PAK3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "Q62829", "standardIdentifier" : "uniprot:Q62829", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10135927 ], "children" : [ ] }, { "dbId" : 10175337, "stId" : "R-RNO-5218766", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:NCK1,NCK2:p-S21,Y420-FYN:PAK2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49241 ], "parents" : [ ], "children" : [ 10175148, 10134861 ] }, { "dbId" : 9619813, "stId" : "R-RNO-9619813", "displayName" : "Rac1:GDP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49109 ], "parents" : [ 10175360 ], "children" : [ 29420, 205143 ] }, { "dbId" : 10135917, "stId" : "R-RNO-399819", "displayName" : "phospho-p-S144,T423-PAK1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P35465", "standardIdentifier" : "uniprot:P35465", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10135927 ], "children" : [ ] }, { "dbId" : 10175331, "stId" : "R-RNO-5218721", "displayName" : "phospho-PTK2B [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48895, "identifier" : "P70600", "standardIdentifier" : "uniprot:P70600", "referenceType" : "ReferenceGeneProduct", "parents" : [ 10175333 ], "children" : [ ] }, { "dbId" : 10175328, "stId" : "R-RNO-5218787", "displayName" : "VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:PTK2B [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49086 ], "parents" : [ ], "children" : [ 10135376, 10175241 ] }, { "dbId" : 10175333, "stId" : "R-RNO-5218778", "displayName" : "VEGFA:p-6Y-VEGFR2:Integrin alphaVbeta3:p-Y402-PTK2B [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48895, "diagramIds" : [ 49089 ], "parents" : [ ], "children" : [ 10175331, 10175241 ] } ], "edges" : [ { "dbId" : 10165787, "stId" : "R-RNO-2316429", "displayName" : "PIP3 recruits PDPK1 to the membrane", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175260 ], "following" : [ 10165951 ], "inputs" : [ 10125381, 179838 ], "outputs" : [ 10111304 ], "efs" : [ ], "diagramIds" : [ 49173 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10123418, "stId" : "R-RNO-198640", "displayName" : "mTORC2 phosphorylates AKT at S473", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 10165951 ], "inputs" : [ 10123376, 113592 ], "outputs" : [ 29370, 10123386 ], "catalysts" : [ 10123407 ], "efs" : [ ], "inhibitors" : [ 10123416 ], "diagramIds" : [ 49176 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175130, "stId" : "R-RNO-5218640", "displayName" : "SRC-1 phosphorylates p-Y397-PTK2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175137 ], "following" : [ 10175135 ], "inputs" : [ 10175127, 113592 ], "outputs" : [ 10172400, 29370 ], "catalysts" : [ 10175127 ], "efs" : [ ], "diagramIds" : [ 49064 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175135, "stId" : "R-RNO-5218643", "displayName" : "HSP90AA1 binds p-6Y-VEGFR2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175130 ], "following" : [ 10175312, 10172404 ], "inputs" : [ 10172400, 10125341 ], "outputs" : [ 10172402 ], "efs" : [ ], "diagramIds" : [ 49071 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10176542, "stId" : "R-RNO-5357477", "displayName" : "PAK1-3 phosphorylates VE-cadherin", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10176532 ], "inputs" : [ 10176534, 113592 ], "outputs" : [ 29370, 10176539 ], "catalysts" : [ 10135927 ], "efs" : [ ], "diagramIds" : [ 49168 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175133, "stId" : "R-RNO-5218642", "displayName" : "PTK2 autophosphorylates", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173221 ], "following" : [ 10175137 ], "inputs" : [ 113592, 10173219 ], "outputs" : [ 10175125, 29370 ], "catalysts" : [ 10173219 ], "efs" : [ ], "diagramIds" : [ 49058 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175260, "stId" : "R-RNO-5218819", "displayName" : "VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10176544 ], "following" : [ 10162615, 10165787 ], "inputs" : [ 113592, 179856 ], "outputs" : [ 179838, 29370 ], "catalysts" : [ 10175257 ], "efs" : [ ], "diagramIds" : [ 49142 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10212883, "stId" : "R-RNO-9679477", "displayName" : "VEGFA-165 dimer binds VEGFA inhibitors", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 10172375, 9679456 ], "outputs" : [ 10212881 ], "efs" : [ ], "diagramIds" : [ 49309 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10176529, "stId" : "R-RNO-5357445", "displayName" : "PAK1-3 dimer disassociates", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10176546 ], "following" : [ 10176532 ], "inputs" : [ 10176525 ], "outputs" : [ 10176527 ], "efs" : [ ], "diagramIds" : [ 49162 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10123030, "stId" : "R-RNO-195418", "displayName" : "NRP-2 associates with VEGFR1 forming complexes on cell surface", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 10122839, 10123026 ], "outputs" : [ 10123028 ], "efs" : [ ], "diagramIds" : [ 49039 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10176532, "stId" : "R-RNO-5357472", "displayName" : "PAK1-3 autophosphorylates", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10176529 ], "following" : [ 10176542 ], "inputs" : [ 113592, 10176527 ], "outputs" : [ 10135927, 29370, 10175362 ], "catalysts" : [ 10134872 ], "efs" : [ ], "diagramIds" : [ 49164 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10176523, "stId" : "R-RNO-5357432", "displayName" : "AXL binds SRC-1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173272 ], "following" : [ 10176521 ], "inputs" : [ 10176516, 10173269 ], "outputs" : [ 10176518 ], "efs" : [ ], "diagramIds" : [ 49132 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175243, "stId" : "R-RNO-5218818", "displayName" : "Integrin alphaVbeta3 binds p-6Y-VEGFR2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173243 ], "following" : [ 10175341 ], "inputs" : [ 10172387, 10127833 ], "outputs" : [ 10175241 ], "efs" : [ ], "diagramIds" : [ 49068 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10176521, "stId" : "R-RNO-5357429", "displayName" : "AXL autophosphorylates on Y779 and Y821", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10176523 ], "following" : [ 10176544 ], "inputs" : [ 10176518, 113592 ], "outputs" : [ 10175253, 29370 ], "catalysts" : [ 10176518 ], "efs" : [ ], "diagramIds" : [ 49135 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175368, "stId" : "R-RNO-5218851", "displayName" : "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175335, 10175312 ], "following" : [ 10175343 ], "inputs" : [ 113592, 10175307 ], "outputs" : [ 10175206, 29370 ], "catalysts" : [ 10175333 ], "efs" : [ ], "diagramIds" : [ 49092 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10125326, "stId" : "R-RNO-202110", "displayName" : "eNOS:Caveolin-1 complex binds to CaM", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 10125361 ], "inputs" : [ 10125317, 10112128 ], "outputs" : [ 10125323 ], "catalysts" : [ 10125317 ], "efs" : [ ], "diagramIds" : [ 49185 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10123022, "stId" : "R-RNO-195408", "displayName" : "NRP-1 forms a ternary complex with VEGF165 and VEGFR1", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 10122814, 10123018 ], "outputs" : [ 10123020 ], "efs" : [ ], "diagramIds" : [ 49036 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175373, "stId" : "R-RNO-5218854", "displayName" : "p-Y420-FYN is phosphorylated on S21", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175197 ], "following" : [ 10175358 ], "inputs" : [ 113592, 10175194 ], "outputs" : [ 29370, 10175148 ], "catalysts" : [ 10175370 ], "efs" : [ ], "diagramIds" : [ 49234 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10123011, "stId" : "R-RNO-195378", "displayName" : "Homodimerization of VEGF proteins", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 10122802, 10122845, 10122820 ], "inputs" : [ 10123007 ], "outputs" : [ 10123009 ], "efs" : [ ], "diagramIds" : [ 49021 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175239, "stId" : "R-RNO-5218815", "displayName" : "p-6Y-VEGFR2 binds NCK", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173243 ], "following" : [ 10175301 ], "inputs" : [ 10130417, 10172387 ], "outputs" : [ 10175143 ], "efs" : [ ], "diagramIds" : [ 49224 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10205574, "stId" : "R-RNO-8951586", "displayName" : "p-VAV family:PIP3 binds RAC1:GDP", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175264 ], "following" : [ 10175365 ], "inputs" : [ 9619813, 10175262 ], "outputs" : [ 10175360 ], "efs" : [ ], "diagramIds" : [ 49305 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175237, "stId" : "R-RNO-5218814", "displayName" : "PAK2 autophorylates", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175339 ], "following" : [ 10175226 ], "inputs" : [ 10175234, 113592 ], "outputs" : [ 10175223, 29370 ], "catalysts" : [ 10175234 ], "efs" : [ ], "diagramIds" : [ 49245 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175365, "stId" : "R-RNO-5218850", "displayName" : "VAV exchanges GTP for GDP on RAC1, activating it", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10205574 ], "following" : [ 10176546, 10175324, 10162615 ], "inputs" : [ 29438, 10175360 ], "outputs" : [ 29420, 10175362 ], "catalysts" : [ 10175360 ], "efs" : [ ], "diagramIds" : [ 49154 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10155908, "stId" : "R-RNO-1497784", "displayName" : "The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10125351 ], "following" : [ 10125356 ], "inputs" : [ 29870, 10125348 ], "outputs" : [ 10125353 ], "catalysts" : [ 10125348 ], "efs" : [ ], "diagramIds" : [ 49203 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10173243, "stId" : "R-RNO-4420117", "displayName" : "VEGFR2 autophosphorylates", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10122820, 10213039 ], "following" : [ 10173238, 10175239, 10175243, 10173227, 10173263, 10173265 ], "inputs" : [ 113592, 10122814, 10173240 ], "outputs" : [ 29370, 10172387 ], "catalysts" : [ 10173240 ], "efs" : [ ], "diagramIds" : [ 49042 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175160, "stId" : "R-RNO-5218804", "displayName" : "p38 MAPK activation by VEGFR", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 10175226 ], "following" : [ 10120912 ], "inputs" : [ 10175141, 113592 ], "outputs" : [ 29370, 10120909 ], "catalysts" : [ 10175157 ], "efs" : [ ], "diagramIds" : [ 49253 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10165951, "stId" : "R-RNO-2317314", "displayName" : "AKT binds PDPK1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10123418, 10165787 ], "inputs" : [ 10111304, 10123386 ], "outputs" : [ 10165949 ], "efs" : [ ], "diagramIds" : [ 49183 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10125374, "stId" : "R-RNO-202137", "displayName" : "AKT1 binds eNOS complex via HSP90", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10125379 ], "following" : [ 10125351 ], "inputs" : [ 10125335, 10116556 ], "outputs" : [ 10125339 ], "catalysts" : [ 10125335 ], "efs" : [ ], "diagramIds" : [ 49195 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175293, "stId" : "R-RNO-5218822", "displayName" : "CRK binds BCAR1 and or PXN", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175217 ], "inputs" : [ 10175289, 10117576 ], "outputs" : [ 10175291 ], "efs" : [ ], "diagramIds" : [ 49103 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10122802, "stId" : "R-RNO-194308", "displayName" : "VEGF-C,D bind to VEGFR3 leading to receptor dimerization", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10123011 ], "inputs" : [ 10122796, 10122792 ], "outputs" : [ 10122800 ], "efs" : [ ], "diagramIds" : [ 49032 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10125361, "stId" : "R-RNO-202129", "displayName" : "HSP90 binds eNOS:Caveolin-1:CaM complex", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10125326 ], "following" : [ 10125379 ], "inputs" : [ 10125341, 10125323 ], "outputs" : [ 10112128, 10125358 ], "catalysts" : [ 10125341 ], "efs" : [ ], "diagramIds" : [ 49189 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10162615, "stId" : "R-RNO-2029465", "displayName" : "RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175348, 10175365, 10175260 ], "inputs" : [ 179838, 10162560, 10162611, 9628560 ], "outputs" : [ 10162613 ], "efs" : [ ], "diagramIds" : [ 49113 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10173238, "stId" : "R-RNO-4420107", "displayName" : "p-6Y-VEGFR2 binds SHC-transforming protein 2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173243 ], "inputs" : [ 10173234, 10172387 ], "outputs" : [ 10173236 ], "efs" : [ ], "diagramIds" : [ 49118 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10173227, "stId" : "R-RNO-4420099", "displayName" : "p-6Y-VEGFR2 binds SHB ", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173243 ], "following" : [ 10173251 ], "inputs" : [ 10173223, 10172387 ], "outputs" : [ 10173225 ], "efs" : [ ], "diagramIds" : [ 49047 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175529, "stId" : "R-RNO-5228992", "displayName" : "ROCK1,ROCK2 are activated", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10172404 ], "following" : [ 10175312 ], "inputs" : [ 10172009 ], "outputs" : [ 10175309 ], "efs" : [ ], "diagramIds" : [ 49078 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10213039, "stId" : "R-RNO-9691215", "displayName" : "VEGFA-165 dimer binds VEGFR2 dimer", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 10173243 ], "inputs" : [ 10172375, 10122814 ], "outputs" : [ 10173240 ], "efs" : [ ], "inhibitors" : [ 10212881 ], "diagramIds" : [ 49306 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10125356, "stId" : "R-RNO-202127", "displayName" : "eNOS synthesizes NO", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10155908 ], "inputs" : [ 29468, 70106, 29368, 29364 ], "outputs" : [ 202124, 29356, 29366, 29968 ], "catalysts" : [ 10125353 ], "efs" : [ ], "inhibitors" : [ 5693375 ], "diagramIds" : [ 49206 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10176546, "stId" : "R-RNO-5357483", "displayName" : "RAC1 binds PAK1-3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175365 ], "following" : [ 10176529 ], "inputs" : [ 10175362, 10134872 ], "outputs" : [ 10176525 ], "efs" : [ ], "diagramIds" : [ 49159 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175137, "stId" : "R-RNO-5218645", "displayName" : "SRC-1 binds p-Y397-PTK2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175133 ], "following" : [ 10175264, 10175130, 10175335 ], "inputs" : [ 10175125, 548926 ], "outputs" : [ 10175127 ], "efs" : [ ], "diagramIds" : [ 49062 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175264, "stId" : "R-RNO-5218820", "displayName" : "Src kinases phosphorylate VAV", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175137 ], "following" : [ 10205574 ], "inputs" : [ 113592, 10139858 ], "outputs" : [ 29370, 10175262 ], "catalysts" : [ 10175127 ], "efs" : [ ], "diagramIds" : [ 49148 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10176544, "stId" : "R-RNO-5357479", "displayName" : "p-AXL binds PI3K", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10176521 ], "following" : [ 10175260 ], "inputs" : [ 10175253, 10108623 ], "outputs" : [ 10175255 ], "efs" : [ ], "diagramIds" : [ 49139 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175271, "stId" : "R-RNO-5218821", "displayName" : "PDK1 phosphorylates PKC", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 10175190 ], "inputs" : [ 10175268, 113592 ], "outputs" : [ 10175172, 29370 ], "catalysts" : [ 10111302 ], "efs" : [ ], "diagramIds" : [ 49275 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175398, "stId" : "R-RNO-5218916", "displayName" : "p-MAPK2/3 phosphorylates HSP27", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 10120912 ], "inputs" : [ 113592, 10175390 ], "outputs" : [ 10135745, 29370, 10175395 ], "catalysts" : [ 10120901 ], "efs" : [ ], "diagramIds" : [ 49258 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10125351, "stId" : "R-RNO-202111", "displayName" : "AKT1 phosphorylates eNOS", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10125374 ], "following" : [ 10155908 ], "inputs" : [ 113592, 10125339 ], "outputs" : [ 10125348, 70106, 29370 ], "catalysts" : [ 10125339 ], "efs" : [ ], "diagramIds" : [ 49198 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10173221, "stId" : "R-RNO-4420083", "displayName" : "PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173251 ], "following" : [ 10175133 ], "inputs" : [ 10125042, 10172394 ], "outputs" : [ 10173219 ], "efs" : [ ], "diagramIds" : [ 49055 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10173272, "stId" : "R-RNO-4420206", "displayName" : "Phosphorylation of SRC-1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173261 ], "following" : [ 10176523 ], "inputs" : [ 113592, 10173259 ], "outputs" : [ 10173269, 29370 ], "catalysts" : [ 10173259 ], "efs" : [ ], "diagramIds" : [ 49128 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175197, "stId" : "R-RNO-5218806", "displayName" : "FYN autophosphorylates", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175301 ], "following" : [ 10175373 ], "inputs" : [ 113592, 10175192 ], "outputs" : [ 29370, 10175194 ], "catalysts" : [ 10175192 ], "efs" : [ ], "diagramIds" : [ 49230 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175324, "stId" : "R-RNO-5218827", "displayName" : "NADPH oxidase 2 (NOX2) complex binds RAC1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175348, 10175365 ], "following" : [ 10175351 ], "inputs" : [ 10175320, 9628560 ], "outputs" : [ 10175322 ], "efs" : [ ], "diagramIds" : [ 49216 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10122845, "stId" : "R-RNO-194311", "displayName" : "VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10123011 ], "inputs" : [ 10122839, 10122834 ], "outputs" : [ 10122843 ], "efs" : [ ], "diagramIds" : [ 49024 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10173267, "stId" : "R-RNO-4420202", "displayName" : "PLCG1 disassociates from VEGFR2 and translocate to PM", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173249 ], "inputs" : [ 10173247 ], "outputs" : [ 10172387, 10125656 ], "efs" : [ ], "diagramIds" : [ 49273 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10120912, "stId" : "R-RNO-187688", "displayName" : "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175160 ], "following" : [ 10175398 ], "inputs" : [ 113592, 10120890 ], "outputs" : [ 10120901, 29370 ], "catalysts" : [ 10120909 ], "efs" : [ ], "diagramIds" : [ 49301 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10173265, "stId" : "R-RNO-4420153", "displayName" : "p-6Y-VEGFR2 binds PLCG1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173243 ], "following" : [ 10173249 ], "inputs" : [ 10172387, 10125512 ], "outputs" : [ 10173245 ], "efs" : [ ], "diagramIds" : [ 49265 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175312, "stId" : "R-RNO-5218826", "displayName" : "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175135, 10175529 ], "following" : [ 10175368 ], "inputs" : [ 10172402, 113592 ], "outputs" : [ 29370, 10175307 ], "catalysts" : [ 10175309 ], "efs" : [ ], "diagramIds" : [ 49080 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175190, "stId" : "R-RNO-5218805", "displayName" : "PKC autophosphorylates", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175271 ], "following" : [ 10175230 ], "inputs" : [ 10175172, 113592 ], "outputs" : [ 29370, 10175187 ], "catalysts" : [ 10175172 ], "efs" : [ ], "diagramIds" : [ 49281 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10173263, "stId" : "R-RNO-4420143", "displayName" : "p-6Y-VEGFR2 binds SH2D2A", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173243 ], "following" : [ 10173261 ], "inputs" : [ 10173255, 10172387 ], "outputs" : [ 10173257 ], "efs" : [ ], "diagramIds" : [ 49122 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10173261, "stId" : "R-RNO-4420140", "displayName" : "SRC1-1 binds SH2D2A and is recruited to VEGFR2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173263 ], "following" : [ 10173272 ], "inputs" : [ 548926, 10173257 ], "outputs" : [ 10173259 ], "efs" : [ ], "diagramIds" : [ 49125 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10173251, "stId" : "R-RNO-4420128", "displayName" : "SRC-1 phosphorylates SHB", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173227 ], "following" : [ 10173221 ], "inputs" : [ 113592, 10173225 ], "outputs" : [ 29370, 10172394 ], "catalysts" : [ 548926 ], "efs" : [ ], "diagramIds" : [ 49050 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175299, "stId" : "R-RNO-5218823", "displayName" : "PKC phosphorylates sphingosine kinase 1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175230 ], "following" : [ 10175356 ], "inputs" : [ 10135444, 113592 ], "outputs" : [ 10175296, 29370 ], "catalysts" : [ 10175228 ], "efs" : [ ], "diagramIds" : [ 49289 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10125379, "stId" : "R-RNO-202144", "displayName" : "Caveolin-1 dissociates from eNOS:CaM:HSP90 complex", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10125361 ], "following" : [ 10125374 ], "inputs" : [ 10125358 ], "outputs" : [ 10125335, 10125376 ], "catalysts" : [ 10125358 ], "efs" : [ ], "diagramIds" : [ 49192 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10173249, "stId" : "R-RNO-4420121", "displayName" : "SFKs phosphorylate PLCG1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10173265 ], "following" : [ 10173267 ], "inputs" : [ 113592, 10173245 ], "outputs" : [ 29370, 10173247 ], "catalysts" : [ 548926 ], "efs" : [ ], "diagramIds" : [ 49268 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175301, "stId" : "R-RNO-5218824", "displayName" : "p-6Y-VEGFR2 binds FYN", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175239 ], "following" : [ 10175197 ], "inputs" : [ 10175143, 374400 ], "outputs" : [ 10175192 ], "efs" : [ ], "diagramIds" : [ 49227 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10122820, "stId" : "R-RNO-194310", "displayName" : "VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10123011 ], "following" : [ 10173243 ], "inputs" : [ 10122814, 10122810 ], "outputs" : [ 10122818 ], "efs" : [ ], "diagramIds" : [ 49028 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175226, "stId" : "R-RNO-5218812", "displayName" : "FYN phosphorylates PAK2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175237 ], "following" : [ 10175160 ], "inputs" : [ 10175223, 113592 ], "outputs" : [ 10175157, 29370 ], "catalysts" : [ 10175223 ], "efs" : [ ], "diagramIds" : [ 49249 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175358, "stId" : "R-RNO-5218847", "displayName" : "PAK2 binds NCK", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175373 ], "following" : [ 10175339 ], "inputs" : [ 10175148, 10134861 ], "outputs" : [ 10175337 ], "efs" : [ ], "diagramIds" : [ 49239 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175230, "stId" : "R-RNO-5218813", "displayName" : "DAG and Ca+2 bind to PKC and tether it to membrane", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175190 ], "following" : [ 10175299 ], "inputs" : [ 10175187, 112275, 74016 ], "outputs" : [ 10175228 ], "efs" : [ ], "diagramIds" : [ 49285 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175356, "stId" : "R-RNO-5218845", "displayName" : "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175299 ], "inputs" : [ 113592, 10175353 ], "outputs" : [ 5218688, 29370, 10120798, 10118107 ], "catalysts" : [ 10175296 ], "efs" : [ ], "diagramIds" : [ 49294 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175217, "stId" : "R-RNO-5218809", "displayName" : "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175343 ], "following" : [ 10175293 ], "inputs" : [ 113592, 10175208 ], "outputs" : [ 29370, 10175214 ], "catalysts" : [ 10175208 ], "efs" : [ ], "diagramIds" : [ 49099 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175351, "stId" : "R-RNO-5218841", "displayName" : "NADPH oxidase 2 generates superoxide from oxygen", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175324 ], "inputs" : [ 29364, 352327 ], "outputs" : [ 70106, 29366, 3299686 ], "catalysts" : [ 10175322 ], "efs" : [ ], "diagramIds" : [ 49220 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175348, "stId" : "R-RNO-5218839", "displayName" : "DOCK180:ELMO exchanges GTP for GDP, activating RAC1", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 10175324, 10162615 ], "inputs" : [ 29438, 9619813 ], "outputs" : [ 29420, 9628560 ], "catalysts" : [ 10175345 ], "efs" : [ ], "diagramIds" : [ 49107 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10172404, "stId" : "R-RNO-3928647", "displayName" : "RHOA:GTP:Mg2+ binds ROCK1,ROCK2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175135 ], "following" : [ 10175529 ], "inputs" : [ 10112948, 10136946 ], "outputs" : [ 10172009 ], "efs" : [ ], "activators" : [ 10172402 ], "diagramIds" : [ 49074 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175339, "stId" : "R-RNO-5218832", "displayName" : "CDC42:GTP binds PAK2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175358 ], "following" : [ 10175237 ], "inputs" : [ 10175337, 10120616 ], "outputs" : [ 10175234 ], "efs" : [ ], "diagramIds" : [ 49242 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175343, "stId" : "R-RNO-5218838", "displayName" : "PXN binds p-6Y,S732-PTK2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175368 ], "following" : [ 10175217 ], "inputs" : [ 10175206, 10175199 ], "outputs" : [ 10175208 ], "efs" : [ ], "diagramIds" : [ 49096 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175341, "stId" : "R-RNO-5218836", "displayName" : "PTK2beta binds alphaVbeta3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175243 ], "following" : [ 10175335 ], "inputs" : [ 10135376, 10175241 ], "outputs" : [ 10175328 ], "efs" : [ ], "diagramIds" : [ 49084 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 10175335, "stId" : "R-RNO-5218830", "displayName" : "SRC-1 phosphorylates PTK2-beta", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 10175137, 10175341 ], "following" : [ 10175368 ], "inputs" : [ 10175328, 113592 ], "outputs" : [ 10175333, 29370 ], "catalysts" : [ 10175127 ], "efs" : [ ], "diagramIds" : [ 49087 ], "entityFunctionalStatus" : [ ] } ], "subpathways" : [ { "dbId" : 10223251, "stId" : "R-RNO-5218920", "displayName" : "VEGFR2 mediated vascular permeability", "events" : [ 10165787, 10123418, 10165951, 10125374, 10176542, 10176529, 10125361, 10176532, 10125326, 10125356, 10176546, 10125379, 10125351, 10155908 ] }, { "dbId" : 10223071, "stId" : "R-RNO-4420097", "displayName" : "VEGFA-VEGFR2 Pathway", "events" : [ 10173221, 10175398, 10175335, 10175264, 10176544, 10175137, 10175341, 10175343, 10213039, 10175529, 10175339, 10173227, 10175348, 10172404, 10173238, 10175351, 10162615, 10175217, 10175293, 10175358, 10175160, 10175226, 10173243, 10175237, 10175301, 10175365, 10205574, 10175239, 10173251, 10175373, 10173261, 10173263, 10175368, 10176521, 10176523, 10175243, 10175312, 10120912, 10175230, 10175356, 10173267, 10175299, 10173265, 10173249, 10175271, 10175190, 10165787, 10123418, 10165951, 10125374, 10176542, 10176529, 10125361, 10176532, 10125326, 10125356, 10176546, 10125379, 10125351, 10155908, 10212883, 10175324, 10175260, 10175197, 10175133, 10175135, 10173272, 10175130 ] }, { "dbId" : 10223215, "stId" : "R-RNO-194306", "displayName" : "Neuropilin interactions with VEGF and VEGFR", "events" : [ 10123022, 10123030 ] }, { "dbId" : 10223205, "stId" : "R-RNO-194313", "displayName" : "VEGF ligand-receptor interactions", "events" : [ 10122845, 10122802, 10122820, 10123011 ] }, { "dbId" : 10224597, "stId" : "R-RNO-5218921", "displayName" : "VEGFR2 mediated cell proliferation", "events" : [ 10175230, 10175356, 10173267, 10175299, 10173265, 10173249, 10175271, 10175190 ] }, { "dbId" : 10223203, "stId" : "R-RNO-195399", "displayName" : "VEGF binds to VEGFR leading to receptor dimerization", "events" : [ 10122845, 10122802, 10122820 ] } ] }