{
  "dbId" : 10222913,
  "stableId" : "R-RNO-170834",
  "displayName" : "Signaling by TGF-beta Receptor Complex",
  "nodes" : [ {
    "id" : 106880,
    "reactomeId" : 10173026,
    "displayName" : "TGFBR2:CBL",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 591,
      "y" : 590
    },
    "minX" : 562,
    "maxX" : 663,
    "minY" : 567,
    "maxY" : 608,
    "prop" : {
      "x" : 562,
      "y" : 573,
      "width" : 59,
      "height" : 34
    },
    "textPosition" : {
      "x" : 562,
      "y" : 572
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 621,
          "y" : 573
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 621,
          "y" : 573
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106881,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 624,
          "y" : 600
        },
        "to" : {
          "x" : 641,
          "y" : 608
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106881,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 624,
          "y" : 590
        },
        "to" : {
          "x" : 651,
          "y" : 590
        }
      }, {
        "from" : {
          "x" : 651,
          "y" : 590
        },
        "to" : {
          "x" : 657,
          "y" : 600
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 659,
          "y" : 603
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 659,
          "y" : 603
        }
      }
    }, {
      "edgeId" : 106878,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106883,
    "reactomeId" : 10173044,
    "displayName" : "Ube2m",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 723,
      "y" : 675
    },
    "minX" : 674,
    "maxX" : 757,
    "minY" : 594,
    "maxY" : 694,
    "prop" : {
      "x" : 695,
      "y" : 656,
      "width" : 56,
      "height" : 38
    },
    "textPosition" : {
      "x" : 697,
      "y" : 664
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 751,
          "y" : 656
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 751,
          "y" : 656
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106881,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 711,
          "y" : 653
        },
        "to" : {
          "x" : 674,
          "y" : 594
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 686,
            "y" : 617
          },
          "b" : {
            "x" : 698,
            "y" : 629
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 692,
            "y" : 623
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 704,
          "y" : 649
        },
        "b" : {
          "x" : 711,
          "y" : 653
        },
        "c" : {
          "x" : 711,
          "y" : 645
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 711,
          "y" : 645
        }
      }
    } ]
  }, {
    "id" : 106882,
    "reactomeId" : 10173042,
    "displayName" : "NEDD8-AcM-UBE2M",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 632,
      "y" : 678
    },
    "minX" : 597,
    "maxX" : 674,
    "minY" : 608,
    "maxY" : 702,
    "prop" : {
      "x" : 597,
      "y" : 654,
      "width" : 71,
      "height" : 48
    },
    "textPosition" : {
      "x" : 605,
      "y" : 653
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 668,
          "y" : 654
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 668,
          "y" : 654
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106881,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 635,
          "y" : 651
        },
        "to" : {
          "x" : 641,
          "y" : 608
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 632,
            "y" : 623
          },
          "b" : {
            "x" : 644,
            "y" : 635
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 638,
            "y" : 629
          }
        }
      }
    } ]
  }, {
    "id" : 106884,
    "reactomeId" : 10173048,
    "displayName" : "NEDD8-K556,K567-TGFBR2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 681,
      "y" : 556
    },
    "minX" : 629,
    "maxX" : 740,
    "minY" : 530,
    "maxY" : 594,
    "prop" : {
      "x" : 629,
      "y" : 536,
      "width" : 105,
      "height" : 40
    },
    "textPosition" : {
      "x" : 636,
      "y" : 538
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 734,
          "y" : 536
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 734,
          "y" : 536
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106881,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 677,
          "y" : 579
        },
        "to" : {
          "x" : 674,
          "y" : 594
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 680,
          "y" : 587
        },
        "b" : {
          "x" : 677,
          "y" : 579
        },
        "c" : {
          "x" : 672,
          "y" : 585
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 672,
          "y" : 585
        }
      }
    } ]
  }, {
    "id" : 106887,
    "reactomeId" : 10118021,
    "displayName" : "p-2S-SMAD2,3:SMAD4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1006,
      "y" : 1232
    },
    "minX" : 952,
    "maxX" : 1061,
    "minY" : 1213,
    "maxY" : 1251,
    "prop" : {
      "x" : 952,
      "y" : 1213,
      "width" : 109,
      "height" : 38
    },
    "textPosition" : {
      "x" : 957,
      "y" : 1214
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 106885,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106886,
    "reactomeId" : 10118003,
    "displayName" : "SMAD4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 817,
      "y" : 1351
    },
    "minX" : 785,
    "maxX" : 875,
    "minY" : 1286,
    "maxY" : 1363,
    "prop" : {
      "x" : 785,
      "y" : 1340,
      "width" : 65,
      "height" : 23
    },
    "textPosition" : {
      "x" : 792,
      "y" : 1341
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 850,
          "y" : 1340
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 850,
          "y" : 1340
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106885,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 827,
          "y" : 1337
        },
        "to" : {
          "x" : 875,
          "y" : 1286
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 845,
            "y" : 1305
          },
          "b" : {
            "x" : 857,
            "y" : 1317
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 851,
            "y" : 1311
          }
        }
      }
    } ]
  }, {
    "id" : 106889,
    "reactomeId" : 10166084,
    "displayName" : "TGFB:LAP",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 761,
      "y" : 231
    },
    "minX" : 716,
    "maxX" : 856,
    "minY" : 221,
    "maxY" : 282,
    "prop" : {
      "x" : 716,
      "y" : 221,
      "width" : 90,
      "height" : 21
    },
    "textPosition" : {
      "x" : 728,
      "y" : 221
    },
    "connectors" : [ {
      "edgeId" : 106888,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 780,
          "y" : 248
        },
        "to" : {
          "x" : 856,
          "y" : 282
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106891,
    "reactomeId" : 10166092,
    "displayName" : "LTBP1,LTBP3:TGFB:LAP",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1043,
      "y" : 286
    },
    "minX" : 998,
    "maxX" : 1089,
    "minY" : 271,
    "maxY" : 302,
    "prop" : {
      "x" : 998,
      "y" : 271,
      "width" : 91,
      "height" : 31
    },
    "textPosition" : {
      "x" : 998,
      "y" : 269
    },
    "connectors" : [ {
      "edgeId" : 106888,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106890,
    "reactomeId" : 10166074,
    "displayName" : "LTBP1, LTBP3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 813,
      "y" : 352
    },
    "minX" : 783,
    "maxX" : 856,
    "minY" : 282,
    "maxY" : 368,
    "prop" : {
      "x" : 783,
      "y" : 336,
      "width" : 61,
      "height" : 32
    },
    "textPosition" : {
      "x" : 787,
      "y" : 335
    },
    "connectors" : [ {
      "edgeId" : 106888,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 822,
          "y" : 330
        },
        "to" : {
          "x" : 856,
          "y" : 282
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 833,
            "y" : 300
          },
          "b" : {
            "x" : 845,
            "y" : 312
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 839,
            "y" : 306
          }
        }
      }
    } ]
  }, {
    "id" : 106893,
    "reactomeId" : 10166023,
    "displayName" : "Ltbp4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 323,
      "y" : 114
    },
    "minX" : 299,
    "maxX" : 405,
    "minY" : 98,
    "maxY" : 230,
    "prop" : {
      "x" : 299,
      "y" : 104,
      "width" : 48,
      "height" : 20
    },
    "textPosition" : {
      "x" : 301,
      "y" : 104
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 347,
          "y" : 104
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 347,
          "y" : 104
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106892,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 330,
          "y" : 127
        },
        "to" : {
          "x" : 405,
          "y" : 230
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106894,
    "reactomeId" : 10166096,
    "displayName" : "LTBP4:TGFB1:LAP1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 577,
      "y" : 213
    },
    "minX" : 518,
    "maxX" : 643,
    "minY" : 195,
    "maxY" : 226,
    "prop" : {
      "x" : 518,
      "y" : 201,
      "width" : 119,
      "height" : 25
    },
    "textPosition" : {
      "x" : 531,
      "y" : 191
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 637,
          "y" : 201
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 637,
          "y" : 201
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106892,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106897,
    "reactomeId" : 10166068,
    "displayName" : "LTBP1:TGFB1:LAP1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 975,
      "y" : 190
    },
    "minX" : 915,
    "maxX" : 1042,
    "minY" : 100,
    "maxY" : 202,
    "prop" : {
      "x" : 915,
      "y" : 179,
      "width" : 121,
      "height" : 23
    },
    "textPosition" : {
      "x" : 929,
      "y" : 167
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1036,
          "y" : 179
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1036,
          "y" : 179
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106895,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 976,
          "y" : 176
        },
        "to" : {
          "x" : 987,
          "y" : 100
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106896,
    "reactomeId" : 10166066,
    "displayName" : "LAP1 binding-integrins",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 866,
      "y" : 59
    },
    "minX" : 790,
    "maxX" : 987,
    "minY" : 49,
    "maxY" : 100,
    "prop" : {
      "x" : 790,
      "y" : 49,
      "width" : 153,
      "height" : 21
    },
    "textPosition" : {
      "x" : 793,
      "y" : 49
    },
    "connectors" : [ {
      "edgeId" : 106895,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 896,
          "y" : 76
        },
        "to" : {
          "x" : 987,
          "y" : 100
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106898,
    "reactomeId" : 10166070,
    "displayName" : "LTBP1:TGFB1:LAP1:LAP1-binding integrins",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1177,
      "y" : 72
    },
    "minX" : 1110,
    "maxX" : 1251,
    "minY" : 41,
    "maxY" : 97,
    "prop" : {
      "x" : 1110,
      "y" : 47,
      "width" : 135,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1114,
      "y" : 48
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1245,
          "y" : 47
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1245,
          "y" : 47
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106895,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106901,
    "reactomeId" : 10166082,
    "displayName" : "TGFB3:LAP3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 527,
      "y" : 365
    },
    "minX" : 484,
    "maxX" : 673,
    "minY" : 212,
    "maxY" : 377,
    "prop" : {
      "x" : 484,
      "y" : 353,
      "width" : 87,
      "height" : 24
    },
    "textPosition" : {
      "x" : 487,
      "y" : 356
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 571,
          "y" : 353
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 571,
          "y" : 353
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106899,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 538,
          "y" : 350
        },
        "to" : {
          "x" : 673,
          "y" : 212
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106900,
    "reactomeId" : 10166226,
    "displayName" : "LAP3-binding integrins",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 640,
      "y" : 64
    },
    "minX" : 566,
    "maxX" : 715,
    "minY" : 54,
    "maxY" : 212,
    "prop" : {
      "x" : 566,
      "y" : 54,
      "width" : 149,
      "height" : 21
    },
    "textPosition" : {
      "x" : 567,
      "y" : 54
    },
    "connectors" : [ {
      "edgeId" : 106899,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 642,
          "y" : 81
        },
        "to" : {
          "x" : 673,
          "y" : 212
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106902,
    "reactomeId" : 10166228,
    "displayName" : "TGF-beta-3:LAP3:LAP3-binding integrins",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 816,
      "y" : 172
    },
    "minX" : 744,
    "maxX" : 894,
    "minY" : 148,
    "maxY" : 191,
    "prop" : {
      "x" : 744,
      "y" : 154,
      "width" : 144,
      "height" : 37
    },
    "textPosition" : {
      "x" : 759,
      "y" : 142
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 888,
          "y" : 154
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 888,
          "y" : 154
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106899,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106905,
    "reactomeId" : 10166033,
    "displayName" : "LTBPs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 181,
      "y" : 146
    },
    "minX" : 153,
    "maxX" : 209,
    "minY" : 133,
    "maxY" : 242,
    "prop" : {
      "x" : 153,
      "y" : 133,
      "width" : 56,
      "height" : 26
    },
    "textPosition" : {
      "x" : 159,
      "y" : 135
    },
    "connectors" : [ {
      "edgeId" : 106903,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 179,
          "y" : 165
        },
        "to" : {
          "x" : 167,
          "y" : 242
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106904,
    "reactomeId" : 10156525,
    "displayName" : "Fibrillin-1",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 85,
      "y" : 223
    },
    "minX" : 46,
    "maxX" : 167,
    "minY" : 211,
    "maxY" : 242,
    "prop" : {
      "x" : 46,
      "y" : 211,
      "width" : 78,
      "height" : 25
    },
    "textPosition" : {
      "x" : 53,
      "y" : 213
    },
    "connectors" : [ {
      "edgeId" : 106903,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 127,
          "y" : 232
        },
        "to" : {
          "x" : 167,
          "y" : 242
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106906,
    "reactomeId" : 10166035,
    "displayName" : "LTBPs:Fibrillin-1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 169,
      "y" : 363
    },
    "minX" : 108,
    "maxX" : 237,
    "minY" : 346,
    "maxY" : 374,
    "prop" : {
      "x" : 108,
      "y" : 352,
      "width" : 123,
      "height" : 22
    },
    "textPosition" : {
      "x" : 118,
      "y" : 353
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 231,
          "y" : 352
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 231,
          "y" : 352
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106903,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106912,
    "reactomeId" : 10222923,
    "displayName" : "Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 1396,
      "y" : 1230
    },
    "minX" : 1225,
    "maxX" : 1568,
    "minY" : 1204,
    "maxY" : 1256,
    "prop" : {
      "x" : 1225,
      "y" : 1204,
      "width" : 343,
      "height" : 52
    },
    "textPosition" : {
      "x" : 1238,
      "y" : 1208
    },
    "connectors" : [ ]
  }, {
    "id" : 106799,
    "reactomeId" : 10117970,
    "displayName" : "TGF-beta-1:LAP1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 254,
      "y" : 654
    },
    "minX" : 212,
    "maxX" : 302,
    "minY" : 631,
    "maxY" : 671,
    "prop" : {
      "x" : 212,
      "y" : 637,
      "width" : 84,
      "height" : 34
    },
    "textPosition" : {
      "x" : 214,
      "y" : 636
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 296,
          "y" : 637
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 296,
          "y" : 637
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106797,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106801,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106798,
    "reactomeId" : 10117962,
    "displayName" : "Pre-TGFB1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 87,
      "y" : 648
    },
    "minX" : 51,
    "maxX" : 129,
    "minY" : 623,
    "maxY" : 667,
    "prop" : {
      "x" : 51,
      "y" : 629,
      "width" : 72,
      "height" : 38
    },
    "textPosition" : {
      "x" : 49,
      "y" : 632
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 123,
          "y" : 629
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 123,
          "y" : 629
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106797,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106800,
    "reactomeId" : 10115278,
    "displayName" : "FURIN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 190,
      "y" : 560
    },
    "minX" : 156,
    "maxX" : 219,
    "minY" : 543,
    "maxY" : 644,
    "prop" : {
      "x" : 168,
      "y" : 549,
      "width" : 45,
      "height" : 23
    },
    "textPosition" : {
      "x" : 168,
      "y" : 550
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 213,
          "y" : 549
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 213,
          "y" : 549
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106797,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 185,
          "y" : 575
        },
        "to" : {
          "x" : 162,
          "y" : 636
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 160,
          "y" : 640
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 160,
          "y" : 640
        }
      }
    } ]
  }, {
    "id" : 106802,
    "reactomeId" : 10120047,
    "displayName" : "TGFB1:LAP1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 373,
      "y" : 273
    },
    "minX" : 330,
    "maxX" : 422,
    "minY" : 230,
    "maxY" : 285,
    "prop" : {
      "x" : 330,
      "y" : 262,
      "width" : 86,
      "height" : 23
    },
    "textPosition" : {
      "x" : 332,
      "y" : 264
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 416,
          "y" : 262
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 416,
          "y" : 262
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106892,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 381,
          "y" : 259
        },
        "to" : {
          "x" : 405,
          "y" : 230
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106801,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106805,
    "reactomeId" : 10117910,
    "displayName" : "Dimeric TGFB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 613,
      "y" : 433
    },
    "minX" : 551,
    "maxX" : 682,
    "minY" : 416,
    "maxY" : 518,
    "prop" : {
      "x" : 551,
      "y" : 422,
      "width" : 125,
      "height" : 23
    },
    "textPosition" : {
      "x" : 565,
      "y" : 424
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 676,
          "y" : 422
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 676,
          "y" : 422
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106803,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 613,
          "y" : 448
        },
        "to" : {
          "x" : 613,
          "y" : 518
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106804,
    "reactomeId" : 10117899,
    "displayName" : "TGFBR2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 540,
      "y" : 544
    },
    "minX" : 511,
    "maxX" : 613,
    "minY" : 518,
    "maxY" : 575,
    "prop" : {
      "x" : 511,
      "y" : 532,
      "width" : 59,
      "height" : 24
    },
    "textPosition" : {
      "x" : 513,
      "y" : 533
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 570,
          "y" : 532
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 570,
          "y" : 532
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106803,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 573,
          "y" : 533
        },
        "to" : {
          "x" : 613,
          "y" : 518
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 587,
            "y" : 519
          },
          "b" : {
            "x" : 599,
            "y" : 531
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 593,
            "y" : 525
          }
        }
      }
    }, {
      "edgeId" : 106878,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 532,
          "y" : 559
        },
        "to" : {
          "x" : 520,
          "y" : 575
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106807,
    "reactomeId" : 10117993,
    "displayName" : "TGFB1,TGFB2:TGFBR3:TGFBR2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 906,
      "y" : 495
    },
    "minX" : 649,
    "maxX" : 970,
    "minY" : 450,
    "maxY" : 533,
    "prop" : {
      "x" : 849,
      "y" : 477,
      "width" : 115,
      "height" : 37
    },
    "textPosition" : {
      "x" : 853,
      "y" : 479
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 964,
          "y" : 477
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 964,
          "y" : 477
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106803,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 846,
          "y" : 483
        },
        "to" : {
          "x" : 690,
          "y" : 450
        }
      }, {
        "from" : {
          "x" : 690,
          "y" : 450
        },
        "to" : {
          "x" : 649,
          "y" : 505
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 650,
          "y" : 497
        },
        "b" : {
          "x" : 649,
          "y" : 505
        },
        "c" : {
          "x" : 656,
          "y" : 502
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 656,
          "y" : 502
        }
      }
    }, {
      "edgeId" : 106809,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 873,
          "y" : 517
        },
        "to" : {
          "x" : 842,
          "y" : 532
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 846,
          "y" : 525
        },
        "b" : {
          "x" : 842,
          "y" : 532
        },
        "c" : {
          "x" : 850,
          "y" : 533
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 850,
          "y" : 533
        }
      }
    } ]
  }, {
    "id" : 106806,
    "reactomeId" : 10117974,
    "displayName" : "Dimeric TGFB1:TGFBR2 homodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 740,
      "y" : 505
    },
    "minX" : 678,
    "maxX" : 818,
    "minY" : 477,
    "maxY" : 532,
    "prop" : {
      "x" : 678,
      "y" : 483,
      "width" : 125,
      "height" : 44
    },
    "textPosition" : {
      "x" : 690,
      "y" : 478
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 803,
          "y" : 483
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 803,
          "y" : 483
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106803,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106809,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 806,
          "y" : 526
        },
        "to" : {
          "x" : 818,
          "y" : 532
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106808,
    "reactomeId" : 10118033,
    "displayName" : "TGFBR3(1-783):TGFB1,TGFB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 539,
      "y" : 473
    },
    "minX" : 499,
    "maxX" : 637,
    "minY" : 449,
    "maxY" : 513,
    "prop" : {
      "x" : 499,
      "y" : 455,
      "width" : 81,
      "height" : 37
    },
    "textPosition" : {
      "x" : 503,
      "y" : 429
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 580,
          "y" : 455
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 580,
          "y" : 455
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106803,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 583,
          "y" : 488
        },
        "to" : {
          "x" : 636,
          "y" : 509
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 635,
          "y" : 513
        },
        "b" : {
          "x" : 637,
          "y" : 505
        },
        "c" : {
          "x" : 636,
          "y" : 509
        },
        "type" : "STOP",
        "centre" : {
          "x" : 636,
          "y" : 509
        }
      }
    } ]
  }, {
    "id" : 106811,
    "reactomeId" : 10117955,
    "displayName" : "TGFB1:TGFBR2:TGFBR1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 914,
      "y" : 550
    },
    "minX" : 845,
    "maxX" : 999,
    "minY" : 516,
    "maxY" : 584,
    "prop" : {
      "x" : 871,
      "y" : 522,
      "width" : 86,
      "height" : 57
    },
    "textPosition" : {
      "x" : 884,
      "y" : 530
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 957,
          "y" : 522
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 957,
          "y" : 522
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106809,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 868,
          "y" : 571
        },
        "to" : {
          "x" : 845,
          "y" : 584
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 864,
          "y" : 578
        },
        "b" : {
          "x" : 868,
          "y" : 571
        },
        "c" : {
          "x" : 860,
          "y" : 571
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 860,
          "y" : 571
        }
      }
    }, {
      "edgeId" : 106813,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 960,
          "y" : 551
        },
        "to" : {
          "x" : 980,
          "y" : 553
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106813,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 960,
          "y" : 529
        },
        "to" : {
          "x" : 981,
          "y" : 518
        }
      }, {
        "from" : {
          "x" : 981,
          "y" : 518
        },
        "to" : {
          "x" : 993,
          "y" : 541
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 995,
          "y" : 544
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 995,
          "y" : 544
        }
      }
    } ]
  }, {
    "id" : 106810,
    "reactomeId" : 10117976,
    "displayName" : "TGFBR1:FKBP1A",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 792,
      "y" : 590
    },
    "minX" : 762,
    "maxX" : 829,
    "minY" : 532,
    "maxY" : 608,
    "prop" : {
      "x" : 762,
      "y" : 572,
      "width" : 61,
      "height" : 36
    },
    "textPosition" : {
      "x" : 763,
      "y" : 573
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 823,
          "y" : 572
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 823,
          "y" : 572
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106809,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 800,
          "y" : 569
        },
        "to" : {
          "x" : 818,
          "y" : 532
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 803,
            "y" : 544
          },
          "b" : {
            "x" : 815,
            "y" : 556
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 809,
            "y" : 550
          }
        }
      }
    } ]
  }, {
    "id" : 106812,
    "reactomeId" : 10116702,
    "displayName" : "Fkbp1a",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 859,
      "y" : 647
    },
    "minX" : 833,
    "maxX" : 892,
    "minY" : 584,
    "maxY" : 658,
    "prop" : {
      "x" : 833,
      "y" : 636,
      "width" : 53,
      "height" : 22
    },
    "textPosition" : {
      "x" : 836,
      "y" : 630
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 886,
          "y" : 636
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 886,
          "y" : 636
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106809,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 856,
          "y" : 633
        },
        "to" : {
          "x" : 845,
          "y" : 584
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 844,
            "y" : 602
          },
          "b" : {
            "x" : 856,
            "y" : 614
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 850,
            "y" : 608
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 851,
          "y" : 627
        },
        "b" : {
          "x" : 856,
          "y" : 633
        },
        "c" : {
          "x" : 858,
          "y" : 625
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 858,
          "y" : 625
        }
      }
    } ]
  }, {
    "id" : 106815,
    "reactomeId" : 10117925,
    "displayName" : "TGFB1:TGFBR2:p-TGFBR1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1098,
      "y" : 563
    },
    "minX" : 994,
    "maxX" : 1402,
    "minY" : 536,
    "maxY" : 846,
    "prop" : {
      "x" : 1047,
      "y" : 542,
      "width" : 103,
      "height" : 43
    },
    "textPosition" : {
      "x" : 1047,
      "y" : 550
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1150,
          "y" : 542
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1150,
          "y" : 542
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106817,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1079,
          "y" : 588
        },
        "to" : {
          "x" : 1019,
          "y" : 654
        }
      }, {
        "from" : {
          "x" : 1019,
          "y" : 654
        },
        "to" : {
          "x" : 994,
          "y" : 846
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106836,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1153,
          "y" : 576
        },
        "to" : {
          "x" : 1402,
          "y" : 643
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106875,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1153,
          "y" : 581
        },
        "to" : {
          "x" : 1335,
          "y" : 650
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106813,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1044,
          "y" : 558
        },
        "to" : {
          "x" : 1019,
          "y" : 556
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1037,
          "y" : 561
        },
        "b" : {
          "x" : 1044,
          "y" : 558
        },
        "c" : {
          "x" : 1037,
          "y" : 553
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1037,
          "y" : 553
        }
      }
    } ]
  }, {
    "id" : 106814,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 967,
      "y" : 608
    },
    "minX" : 948,
    "maxX" : 988,
    "minY" : 553,
    "maxY" : 623,
    "prop" : {
      "x" : 948,
      "y" : 593,
      "width" : 39,
      "height" : 30
    },
    "textPosition" : {
      "x" : 952,
      "y" : 597
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 982,
          "y" : 598
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 982,
          "y" : 598
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106813,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 970,
          "y" : 590
        },
        "to" : {
          "x" : 980,
          "y" : 553
        }
      } ],
      "stoichiometry" : {
        "value" : 12,
        "shape" : {
          "a" : {
            "x" : 969,
            "y" : 565
          },
          "b" : {
            "x" : 981,
            "y" : 577
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 975,
            "y" : 571
          }
        }
      }
    } ]
  }, {
    "id" : 106816,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1026,
      "y" : 610
    },
    "minX" : 1006,
    "maxX" : 1048,
    "minY" : 556,
    "maxY" : 625,
    "prop" : {
      "x" : 1006,
      "y" : 595,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1010,
      "y" : 599
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1042,
          "y" : 600
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1042,
          "y" : 600
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106813,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1024,
          "y" : 592
        },
        "to" : {
          "x" : 1019,
          "y" : 556
        }
      } ],
      "stoichiometry" : {
        "value" : 12,
        "shape" : {
          "a" : {
            "x" : 1015,
            "y" : 568
          },
          "b" : {
            "x" : 1027,
            "y" : 580
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1021,
            "y" : 574
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1019,
          "y" : 586
        },
        "b" : {
          "x" : 1024,
          "y" : 592
        },
        "c" : {
          "x" : 1027,
          "y" : 585
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1027,
          "y" : 585
        }
      }
    } ]
  }, {
    "id" : 106819,
    "reactomeId" : 10117945,
    "displayName" : "SMAD2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1062,
      "y" : 764
    },
    "minX" : 826,
    "maxX" : 1096,
    "minY" : 669,
    "maxY" : 948,
    "prop" : {
      "x" : 1029,
      "y" : 753,
      "width" : 67,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1031,
      "y" : 753
    },
    "connectors" : [ {
      "edgeId" : 106817,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1052,
          "y" : 781
        },
        "to" : {
          "x" : 994,
          "y" : 846
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106859,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1065,
          "y" : 747
        },
        "to" : {
          "x" : 1089,
          "y" : 669
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106872,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1023,
          "y" : 764
        },
        "to" : {
          "x" : 986,
          "y" : 764
        }
      }, {
        "from" : {
          "x" : 986,
          "y" : 764
        },
        "to" : {
          "x" : 826,
          "y" : 948
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1016,
          "y" : 768
        },
        "b" : {
          "x" : 1023,
          "y" : 764
        },
        "c" : {
          "x" : 1016,
          "y" : 760
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1016,
          "y" : 760
        }
      }
    } ]
  }, {
    "id" : 106818,
    "reactomeId" : 10117929,
    "displayName" : "Zfyve9",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1132,
      "y" : 907
    },
    "minX" : 994,
    "maxX" : 1174,
    "minY" : 846,
    "maxY" : 918,
    "prop" : {
      "x" : 1096,
      "y" : 897,
      "width" : 72,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1107,
      "y" : 897
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1168,
          "y" : 897
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1168,
          "y" : 897
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106817,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1108,
          "y" : 894
        },
        "to" : {
          "x" : 994,
          "y" : 846
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106820,
    "reactomeId" : 10117947,
    "displayName" : "TGFB1:p-TGFBR:ZFYVE9:SMAD2/3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 971,
      "y" : 904
    },
    "minX" : 883,
    "maxX" : 1065,
    "minY" : 880,
    "maxY" : 991,
    "prop" : {
      "x" : 883,
      "y" : 886,
      "width" : 176,
      "height" : 37
    },
    "textPosition" : {
      "x" : 892,
      "y" : 888
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1059,
          "y" : 886
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1059,
          "y" : 886
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106817,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106821,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 966,
          "y" : 926
        },
        "to" : {
          "x" : 953,
          "y" : 973
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106821,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 955,
          "y" : 926
        },
        "to" : {
          "x" : 922,
          "y" : 964
        }
      }, {
        "from" : {
          "x" : 922,
          "y" : 964
        },
        "to" : {
          "x" : 942,
          "y" : 985
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 945,
          "y" : 987
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 945,
          "y" : 987
        }
      }
    } ]
  }, {
    "id" : 106823,
    "reactomeId" : 10118025,
    "displayName" : "TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 946,
      "y" : 1076
    },
    "minX" : 873,
    "maxX" : 1026,
    "minY" : 1015,
    "maxY" : 1093,
    "prop" : {
      "x" : 873,
      "y" : 1059,
      "width" : 147,
      "height" : 34
    },
    "textPosition" : {
      "x" : 873,
      "y" : 1058
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1020,
          "y" : 1059
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1020,
          "y" : 1059
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106821,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 947,
          "y" : 1056
        },
        "to" : {
          "x" : 953,
          "y" : 1015
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 944,
          "y" : 1049
        },
        "b" : {
          "x" : 947,
          "y" : 1056
        },
        "c" : {
          "x" : 952,
          "y" : 1050
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 952,
          "y" : 1050
        }
      }
    }, {
      "edgeId" : 106825,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106822,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1014,
      "y" : 965
    },
    "minX" : 953,
    "maxX" : 1033,
    "minY" : 952,
    "maxY" : 977,
    "prop" : {
      "x" : 996,
      "y" : 953,
      "width" : 36,
      "height" : 24
    },
    "textPosition" : {
      "x" : 998,
      "y" : 954
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1027,
          "y" : 958
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1027,
          "y" : 958
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106821,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 993,
          "y" : 967
        },
        "to" : {
          "x" : 953,
          "y" : 973
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 967,
            "y" : 964
          },
          "b" : {
            "x" : 979,
            "y" : 976
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 973,
            "y" : 970
          }
        }
      }
    } ]
  }, {
    "id" : 106824,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1010,
      "y" : 1016
    },
    "minX" : 953,
    "maxX" : 1030,
    "minY" : 1004,
    "maxY" : 1028,
    "prop" : {
      "x" : 992,
      "y" : 1005,
      "width" : 37,
      "height" : 23
    },
    "textPosition" : {
      "x" : 994,
      "y" : 1006
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1024,
          "y" : 1010
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1024,
          "y" : 1010
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106821,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 989,
          "y" : 1015
        },
        "to" : {
          "x" : 953,
          "y" : 1015
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 965,
            "y" : 1009
          },
          "b" : {
            "x" : 977,
            "y" : 1021
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 971,
            "y" : 1015
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 982,
          "y" : 1019
        },
        "b" : {
          "x" : 989,
          "y" : 1015
        },
        "c" : {
          "x" : 982,
          "y" : 1011
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 982,
          "y" : 1011
        }
      }
    } ]
  }, {
    "id" : 106827,
    "reactomeId" : 10118027,
    "displayName" : "TGFB1:p-TGFBR:ZFYVE9",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1106,
      "y" : 1054
    },
    "minX" : 983,
    "maxX" : 1166,
    "minY" : 1030,
    "maxY" : 1129,
    "prop" : {
      "x" : 1053,
      "y" : 1036,
      "width" : 107,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1053,
      "y" : 1037
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1160,
          "y" : 1036
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1160,
          "y" : 1036
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106825,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1076,
          "y" : 1075
        },
        "to" : {
          "x" : 983,
          "y" : 1129
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1072,
          "y" : 1082
        },
        "b" : {
          "x" : 1076,
          "y" : 1075
        },
        "c" : {
          "x" : 1068,
          "y" : 1075
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1068,
          "y" : 1075
        }
      }
    } ]
  }, {
    "id" : 106826,
    "reactomeId" : 10118013,
    "displayName" : "p-2S-SMAD2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 797,
      "y" : 1256
    },
    "minX" : 742,
    "maxX" : 983,
    "minY" : 1119,
    "maxY" : 1286,
    "prop" : {
      "x" : 742,
      "y" : 1244,
      "width" : 111,
      "height" : 24
    },
    "textPosition" : {
      "x" : 750,
      "y" : 1245
    },
    "connectors" : [ {
      "edgeId" : 106885,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 828,
          "y" : 1274
        },
        "to" : {
          "x" : 875,
          "y" : 1286
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 845,
            "y" : 1274
          },
          "b" : {
            "x" : 857,
            "y" : 1286
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 851,
            "y" : 1280
          }
        }
      }
    }, {
      "edgeId" : 106825,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 814,
          "y" : 1238
        },
        "to" : {
          "x" : 983,
          "y" : 1129
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 818,
          "y" : 1231
        },
        "b" : {
          "x" : 814,
          "y" : 1238
        },
        "c" : {
          "x" : 822,
          "y" : 1238
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 822,
          "y" : 1238
        }
      }
    }, {
      "edgeId" : 106856,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 820,
          "y" : 1238
        },
        "to" : {
          "x" : 920,
          "y" : 1193
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106869,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 805,
          "y" : 1238
        },
        "to" : {
          "x" : 889,
          "y" : 1119
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106829,
    "reactomeId" : 10164255,
    "displayName" : "Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 527,
      "y" : 993
    },
    "minX" : 413,
    "maxX" : 648,
    "minY" : 969,
    "maxY" : 1027,
    "prop" : {
      "x" : 413,
      "y" : 975,
      "width" : 229,
      "height" : 37
    },
    "textPosition" : {
      "x" : 417,
      "y" : 977
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 642,
          "y" : 975
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 642,
          "y" : 975
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106828,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 525,
          "y" : 1015
        },
        "to" : {
          "x" : 525,
          "y" : 1027
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106831,
    "reactomeId" : 10164257,
    "displayName" : "Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 526,
      "y" : 1089
    },
    "minX" : 405,
    "maxX" : 654,
    "minY" : 1064,
    "maxY" : 1126,
    "prop" : {
      "x" : 405,
      "y" : 1070,
      "width" : 243,
      "height" : 38
    },
    "textPosition" : {
      "x" : 414,
      "y" : 1059
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 648,
          "y" : 1070
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 648,
          "y" : 1070
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106828,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106832,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 523,
          "y" : 1111
        },
        "to" : {
          "x" : 522,
          "y" : 1126
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106830,
    "reactomeId" : 10124812,
    "displayName" : "Smurf1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 636,
      "y" : 1029
    },
    "minX" : 525,
    "maxX" : 672,
    "minY" : 1013,
    "maxY" : 1040,
    "prop" : {
      "x" : 606,
      "y" : 1019,
      "width" : 60,
      "height" : 21
    },
    "textPosition" : {
      "x" : 610,
      "y" : 1019
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 666,
          "y" : 1019
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 666,
          "y" : 1019
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106828,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 603,
          "y" : 1028
        },
        "to" : {
          "x" : 525,
          "y" : 1027
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106833,
    "reactomeId" : 10103388,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 576,
      "y" : 1128
    },
    "minX" : 522,
    "maxX" : 598,
    "minY" : 1117,
    "maxY" : 1139,
    "prop" : {
      "x" : 555,
      "y" : 1117,
      "width" : 43,
      "height" : 22
    },
    "textPosition" : {
      "x" : 564,
      "y" : 1117
    },
    "connectors" : [ {
      "edgeId" : 106832,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 549,
          "y" : 1127
        },
        "to" : {
          "x" : 522,
          "y" : 1126
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106834,
    "reactomeId" : 10164259,
    "displayName" : "Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 524,
      "y" : 1192
    },
    "minX" : 400,
    "maxX" : 655,
    "minY" : 1166,
    "maxY" : 1212,
    "prop" : {
      "x" : 400,
      "y" : 1172,
      "width" : 249,
      "height" : 40
    },
    "textPosition" : {
      "x" : 401,
      "y" : 1177
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 649,
          "y" : 1172
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 649,
          "y" : 1172
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106832,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106835,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106837,
    "reactomeId" : 10118209,
    "displayName" : "SMAD7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1425,
      "y" : 726
    },
    "minX" : 1335,
    "maxX" : 1467,
    "minY" : 621,
    "maxY" : 737,
    "prop" : {
      "x" : 1389,
      "y" : 716,
      "width" : 72,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1399,
      "y" : 716
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1461,
          "y" : 716
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1461,
          "y" : 716
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106836,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1422,
          "y" : 713
        },
        "to" : {
          "x" : 1402,
          "y" : 643
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106839,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1420,
          "y" : 713
        },
        "to" : {
          "x" : 1378,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106875,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1412,
          "y" : 713
        },
        "to" : {
          "x" : 1335,
          "y" : 650
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106838,
    "reactomeId" : 10118224,
    "displayName" : "TGFB1: p-TGFBR: I-SMAD7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1509,
      "y" : 602
    },
    "minX" : 1476,
    "maxX" : 1548,
    "minY" : 571,
    "maxY" : 627,
    "prop" : {
      "x" : 1476,
      "y" : 577,
      "width" : 66,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1476,
      "y" : 578
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1542,
          "y" : 577
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1542,
          "y" : 577
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106836,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106841,
    "reactomeId" : 10163581,
    "displayName" : "TGFB1: p-TGFBR: STRAP: SMAD7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1482,
      "y" : 539
    },
    "minX" : 1449,
    "maxX" : 1521,
    "minY" : 503,
    "maxY" : 569,
    "prop" : {
      "x" : 1449,
      "y" : 509,
      "width" : 66,
      "height" : 60
    },
    "textPosition" : {
      "x" : 1449,
      "y" : 506
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1515,
          "y" : 509
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1515,
          "y" : 509
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106839,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106840,
    "reactomeId" : 10163579,
    "displayName" : "TGFB1:p-TGFBR:STRAP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1285,
      "y" : 570
    },
    "minX" : 1230,
    "maxX" : 1378,
    "minY" : 546,
    "maxY" : 621,
    "prop" : {
      "x" : 1230,
      "y" : 552,
      "width" : 110,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1232,
      "y" : 553
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1340,
          "y" : 552
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1340,
          "y" : 552
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106839,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1317,
          "y" : 591
        },
        "to" : {
          "x" : 1378,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106843,
    "reactomeId" : 10120414,
    "displayName" : "SMAD7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1380,
      "y" : 1310
    },
    "minX" : 1354,
    "maxX" : 1484,
    "minY" : 1293,
    "maxY" : 1322,
    "prop" : {
      "x" : 1354,
      "y" : 1299,
      "width" : 52,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1354,
      "y" : 1300
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1406,
          "y" : 1299
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1406,
          "y" : 1299
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106842,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1409,
          "y" : 1310
        },
        "to" : {
          "x" : 1484,
          "y" : 1312
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106845,
    "reactomeId" : 10120418,
    "displayName" : "SMAD7:SMURF2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1581,
      "y" : 1321
    },
    "minX" : 1527,
    "maxX" : 1641,
    "minY" : 1304,
    "maxY" : 1332,
    "prop" : {
      "x" : 1527,
      "y" : 1310,
      "width" : 108,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1528,
      "y" : 1311
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1635,
          "y" : 1310
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1635,
          "y" : 1310
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106842,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106844,
    "reactomeId" : 10120416,
    "displayName" : "Smurf2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1459,
      "y" : 1276
    },
    "minX" : 1431,
    "maxX" : 1493,
    "minY" : 1259,
    "maxY" : 1312,
    "prop" : {
      "x" : 1431,
      "y" : 1265,
      "width" : 56,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1433,
      "y" : 1265
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1487,
          "y" : 1265
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1487,
          "y" : 1265
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106842,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1466,
          "y" : 1290
        },
        "to" : {
          "x" : 1484,
          "y" : 1312
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106847,
    "reactomeId" : 10164990,
    "displayName" : "TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1954,
      "y" : 570
    },
    "minX" : 1901,
    "maxX" : 2014,
    "minY" : 540,
    "maxY" : 595,
    "prop" : {
      "x" : 1901,
      "y" : 546,
      "width" : 107,
      "height" : 49
    },
    "textPosition" : {
      "x" : 1903,
      "y" : 546
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2008,
          "y" : 546
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2008,
          "y" : 546
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106846,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106849,
    "reactomeId" : 10117936,
    "displayName" : "SMAD2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1129,
      "y" : 730
    },
    "minX" : 1104,
    "maxX" : 1161,
    "minY" : 698,
    "maxY" : 741,
    "prop" : {
      "x" : 1104,
      "y" : 720,
      "width" : 51,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1104,
      "y" : 720
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1155,
          "y" : 720
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1155,
          "y" : 720
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106848,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1127,
          "y" : 717
        },
        "to" : {
          "x" : 1123,
          "y" : 698
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106851,
    "reactomeId" : 10118232,
    "displayName" : "SMAD2:SMURF2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1195,
      "y" : 741
    },
    "minX" : 1165,
    "maxX" : 1252,
    "minY" : 718,
    "maxY" : 759,
    "prop" : {
      "x" : 1165,
      "y" : 724,
      "width" : 61,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1166,
      "y" : 724
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1226,
          "y" : 724
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1226,
          "y" : 724
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106848,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106854,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1229,
          "y" : 740
        },
        "to" : {
          "x" : 1240,
          "y" : 740
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106854,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1229,
          "y" : 726
        },
        "to" : {
          "x" : 1236,
          "y" : 721
        }
      }, {
        "from" : {
          "x" : 1236,
          "y" : 721
        },
        "to" : {
          "x" : 1245,
          "y" : 729
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1248,
          "y" : 732
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1248,
          "y" : 732
        }
      }
    } ]
  }, {
    "id" : 106850,
    "reactomeId" : 10118230,
    "displayName" : "Smurf2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1160,
      "y" : 671
    },
    "minX" : 1123,
    "maxX" : 1275,
    "minY" : 654,
    "maxY" : 736,
    "prop" : {
      "x" : 1131,
      "y" : 660,
      "width" : 58,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1134,
      "y" : 660
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1189,
          "y" : 660
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1189,
          "y" : 660
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106848,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1144,
          "y" : 685
        },
        "to" : {
          "x" : 1123,
          "y" : 698
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106854,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1179,
          "y" : 685
        },
        "to" : {
          "x" : 1275,
          "y" : 736
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1187,
          "y" : 685
        },
        "b" : {
          "x" : 1179,
          "y" : 685
        },
        "c" : {
          "x" : 1183,
          "y" : 692
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1183,
          "y" : 692
        }
      }
    } ]
  }, {
    "id" : 106853,
    "reactomeId" : 10118234,
    "displayName" : "Ub-SMAD2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1333,
      "y" : 732
    },
    "minX" : 1275,
    "maxX" : 1378,
    "minY" : 715,
    "maxY" : 743,
    "prop" : {
      "x" : 1294,
      "y" : 721,
      "width" : 78,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1297,
      "y" : 722
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1372,
          "y" : 721
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1372,
          "y" : 721
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106852,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106854,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1291,
          "y" : 734
        },
        "to" : {
          "x" : 1275,
          "y" : 736
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1285,
          "y" : 739
        },
        "b" : {
          "x" : 1291,
          "y" : 734
        },
        "c" : {
          "x" : 1284,
          "y" : 731
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1284,
          "y" : 731
        }
      }
    } ]
  }, {
    "id" : 106855,
    "reactomeId" : 10103388,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1247,
      "y" : 788
    },
    "minX" : 1218,
    "maxX" : 1277,
    "minY" : 740,
    "maxY" : 843,
    "prop" : {
      "x" : 1218,
      "y" : 777,
      "width" : 59,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1235,
      "y" : 777
    },
    "connectors" : [ {
      "edgeId" : 106854,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1245,
          "y" : 771
        },
        "to" : {
          "x" : 1240,
          "y" : 740
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106866,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1246,
          "y" : 805
        },
        "to" : {
          "x" : 1245,
          "y" : 843
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106857,
    "reactomeId" : 10165274,
    "displayName" : "PMEPA1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1068,
      "y" : 1110
    },
    "minX" : 920,
    "maxX" : 1103,
    "minY" : 1093,
    "maxY" : 1193,
    "prop" : {
      "x" : 1040,
      "y" : 1099,
      "width" : 57,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1043,
      "y" : 1093
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1097,
          "y" : 1099
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1097,
          "y" : 1099
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106856,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1048,
          "y" : 1124
        },
        "to" : {
          "x" : 920,
          "y" : 1193
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106858,
    "reactomeId" : 10165276,
    "displayName" : "p-2S-SMAD2/3:PMEPA1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1152,
      "y" : 1129
    },
    "minX" : 1101,
    "maxX" : 1210,
    "minY" : 1106,
    "maxY" : 1147,
    "prop" : {
      "x" : 1101,
      "y" : 1112,
      "width" : 103,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1103,
      "y" : 1112
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1204,
          "y" : 1112
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1204,
          "y" : 1112
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106856,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106861,
    "reactomeId" : 10165282,
    "displayName" : "SMAD2/3:PMEPA1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1168,
      "y" : 626
    },
    "minX" : 1134,
    "maxX" : 1208,
    "minY" : 603,
    "maxY" : 644,
    "prop" : {
      "x" : 1134,
      "y" : 609,
      "width" : 68,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1134,
      "y" : 609
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1202,
          "y" : 609
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1202,
          "y" : 609
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106859,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106860,
    "reactomeId" : 10165280,
    "displayName" : "PMEPA1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1098,
      "y" : 619
    },
    "minX" : 1071,
    "maxX" : 1132,
    "minY" : 603,
    "maxY" : 669,
    "prop" : {
      "x" : 1071,
      "y" : 609,
      "width" : 55,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1073,
      "y" : 602
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1126,
          "y" : 609
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1126,
          "y" : 609
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106859,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1096,
          "y" : 633
        },
        "to" : {
          "x" : 1089,
          "y" : 669
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106863,
    "reactomeId" : 10117943,
    "displayName" : "SMAD3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1164,
      "y" : 796
    },
    "minX" : 1138,
    "maxX" : 1196,
    "minY" : 781,
    "maxY" : 827,
    "prop" : {
      "x" : 1138,
      "y" : 787,
      "width" : 52,
      "height" : 18
    },
    "textPosition" : {
      "x" : 1138,
      "y" : 786
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1190,
          "y" : 787
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1190,
          "y" : 787
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106862,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1157,
          "y" : 808
        },
        "to" : {
          "x" : 1143,
          "y" : 827
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106865,
    "reactomeId" : 10165286,
    "displayName" : "SMAD3:STUB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1197,
      "y" : 849
    },
    "minX" : 1171,
    "maxX" : 1258,
    "minY" : 827,
    "maxY" : 866,
    "prop" : {
      "x" : 1171,
      "y" : 833,
      "width" : 53,
      "height" : 33
    },
    "textPosition" : {
      "x" : 1171,
      "y" : 831
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1224,
          "y" : 833
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1224,
          "y" : 833
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106862,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106866,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1227,
          "y" : 845
        },
        "to" : {
          "x" : 1245,
          "y" : 843
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106866,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1227,
          "y" : 856
        },
        "to" : {
          "x" : 1244,
          "y" : 863
        }
      }, {
        "from" : {
          "x" : 1244,
          "y" : 863
        },
        "to" : {
          "x" : 1251,
          "y" : 855
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1254,
          "y" : 852
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1254,
          "y" : 852
        }
      }
    } ]
  }, {
    "id" : 106864,
    "reactomeId" : 10148822,
    "displayName" : "STUB1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1113,
      "y" : 849
    },
    "minX" : 1089,
    "maxX" : 1278,
    "minY" : 827,
    "maxY" : 890,
    "prop" : {
      "x" : 1089,
      "y" : 838,
      "width" : 48,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1089,
      "y" : 838
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1137,
          "y" : 838
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1137,
          "y" : 838
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106862,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1128,
          "y" : 835
        },
        "to" : {
          "x" : 1143,
          "y" : 827
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106866,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1140,
          "y" : 857
        },
        "to" : {
          "x" : 1232,
          "y" : 890
        }
      }, {
        "from" : {
          "x" : 1232,
          "y" : 890
        },
        "to" : {
          "x" : 1278,
          "y" : 843
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1148,
          "y" : 856
        },
        "b" : {
          "x" : 1140,
          "y" : 857
        },
        "c" : {
          "x" : 1145,
          "y" : 863
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1145,
          "y" : 863
        }
      }
    } ]
  }, {
    "id" : 106867,
    "reactomeId" : 10165288,
    "displayName" : "Ub-SMAD3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1333,
      "y" : 844
    },
    "minX" : 1278,
    "maxX" : 1375,
    "minY" : 827,
    "maxY" : 855,
    "prop" : {
      "x" : 1297,
      "y" : 833,
      "width" : 72,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1297,
      "y" : 834
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1369,
          "y" : 833
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1369,
          "y" : 833
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106866,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1294,
          "y" : 843
        },
        "to" : {
          "x" : 1278,
          "y" : 843
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1287,
          "y" : 847
        },
        "b" : {
          "x" : 1294,
          "y" : 843
        },
        "c" : {
          "x" : 1287,
          "y" : 839
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1287,
          "y" : 839
        }
      }
    }, {
      "edgeId" : 106868,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106871,
    "reactomeId" : 10165303,
    "displayName" : "p-2S-SMAD2/3:MTMR4",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 818,
      "y" : 1038
    },
    "minX" : 766,
    "maxX" : 876,
    "minY" : 973,
    "maxY" : 1057,
    "prop" : {
      "x" : 766,
      "y" : 1020,
      "width" : 104,
      "height" : 37
    },
    "textPosition" : {
      "x" : 768,
      "y" : 1022
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 870,
          "y" : 1020
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 870,
          "y" : 1020
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106869,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106872,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 816,
          "y" : 1017
        },
        "to" : {
          "x" : 814,
          "y" : 996
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106872,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 830,
          "y" : 1017
        },
        "to" : {
          "x" : 844,
          "y" : 999
        }
      }, {
        "from" : {
          "x" : 844,
          "y" : 999
        },
        "to" : {
          "x" : 824,
          "y" : 980
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 822,
          "y" : 977
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 822,
          "y" : 977
        }
      }
    } ]
  }, {
    "id" : 106870,
    "reactomeId" : 10165301,
    "displayName" : "MTMR4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 815,
      "y" : 1104
    },
    "minX" : 729,
    "maxX" : 889,
    "minY" : 947,
    "maxY" : 1119,
    "prop" : {
      "x" : 784,
      "y" : 1095,
      "width" : 63,
      "height" : 19
    },
    "textPosition" : {
      "x" : 790,
      "y" : 1094
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 847,
          "y" : 1095
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 847,
          "y" : 1095
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106869,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 850,
          "y" : 1110
        },
        "to" : {
          "x" : 889,
          "y" : 1119
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106872,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 800,
          "y" : 1092
        },
        "to" : {
          "x" : 729,
          "y" : 1047
        }
      }, {
        "from" : {
          "x" : 729,
          "y" : 1047
        },
        "to" : {
          "x" : 736,
          "y" : 947
        }
      }, {
        "from" : {
          "x" : 736,
          "y" : 947
        },
        "to" : {
          "x" : 826,
          "y" : 948
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 792,
          "y" : 1092
        },
        "b" : {
          "x" : 800,
          "y" : 1092
        },
        "c" : {
          "x" : 796,
          "y" : 1085
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 796,
          "y" : 1085
        }
      }
    } ]
  }, {
    "id" : 106873,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 786,
      "y" : 995
    },
    "minX" : 766,
    "maxX" : 814,
    "minY" : 982,
    "maxY" : 1007,
    "prop" : {
      "x" : 766,
      "y" : 983,
      "width" : 40,
      "height" : 24
    },
    "textPosition" : {
      "x" : 769,
      "y" : 984
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 801,
          "y" : 988
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 801,
          "y" : 988
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106872,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 809,
          "y" : 995
        },
        "to" : {
          "x" : 814,
          "y" : 996
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 106874,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 771,
      "y" : 911
    },
    "minX" : 754,
    "maxX" : 826,
    "minY" : 900,
    "maxY" : 948,
    "prop" : {
      "x" : 754,
      "y" : 901,
      "width" : 35,
      "height" : 21
    },
    "textPosition" : {
      "x" : 762,
      "y" : 901
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 784,
          "y" : 906
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 784,
          "y" : 906
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106872,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 786,
          "y" : 925
        },
        "to" : {
          "x" : 826,
          "y" : 948
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 794,
          "y" : 925
        },
        "b" : {
          "x" : 786,
          "y" : 925
        },
        "c" : {
          "x" : 790,
          "y" : 932
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 790,
          "y" : 932
        }
      }
    } ]
  }, {
    "id" : 106877,
    "reactomeId" : 10118211,
    "displayName" : "TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1386,
      "y" : 527
    },
    "minX" : 1348,
    "maxX" : 1430,
    "minY" : 484,
    "maxY" : 565,
    "prop" : {
      "x" : 1348,
      "y" : 490,
      "width" : 76,
      "height" : 75
    },
    "textPosition" : {
      "x" : 1348,
      "y" : 488
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1424,
          "y" : 490
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1424,
          "y" : 490
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106875,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106876,
    "reactomeId" : 10118205,
    "displayName" : "Bambi",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1284,
      "y" : 692
    },
    "minX" : 1259,
    "maxX" : 1335,
    "minY" : 650,
    "maxY" : 703,
    "prop" : {
      "x" : 1259,
      "y" : 681,
      "width" : 51,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1261,
      "y" : 681
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1310,
          "y" : 681
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1310,
          "y" : 681
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106875,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1297,
          "y" : 678
        },
        "to" : {
          "x" : 1335,
          "y" : 650
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106879,
    "reactomeId" : 10120485,
    "displayName" : "Cbl",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 568,
      "y" : 644
    },
    "minX" : 520,
    "maxX" : 680,
    "minY" : 575,
    "maxY" : 717,
    "prop" : {
      "x" : 550,
      "y" : 632,
      "width" : 36,
      "height" : 24
    },
    "textPosition" : {
      "x" : 554,
      "y" : 633
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 586,
          "y" : 632
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 586,
          "y" : 632
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106881,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 571,
          "y" : 659
        },
        "to" : {
          "x" : 590,
          "y" : 717
        }
      }, {
        "from" : {
          "x" : 590,
          "y" : 717
        },
        "to" : {
          "x" : 680,
          "y" : 716
        }
      }, {
        "from" : {
          "x" : 680,
          "y" : 716
        },
        "to" : {
          "x" : 674,
          "y" : 594
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 577,
          "y" : 664
        },
        "b" : {
          "x" : 571,
          "y" : 659
        },
        "c" : {
          "x" : 569,
          "y" : 667
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 569,
          "y" : 667
        }
      }
    }, {
      "edgeId" : 106878,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 559,
          "y" : 629
        },
        "to" : {
          "x" : 520,
          "y" : 575
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 106881,
    "reactomeId" : 10173051,
    "displayName" : "CBL neddylates TGFBR2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 666,
      "y" : 613
    },
    "minX" : 641,
    "maxX" : 674,
    "minY" : 594,
    "maxY" : 619,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 641,
        "y" : 608
      },
      "to" : {
        "x" : 666,
        "y" : 613
      }
    }, {
      "from" : {
        "x" : 666,
        "y" : 613
      },
      "to" : {
        "x" : 674,
        "y" : 594
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 660,
        "y" : 607
      },
      "b" : {
        "x" : 672,
        "y" : 619
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 666,
        "y" : 613
      }
    },
    "inputs" : [ {
      "id" : 106880,
      "points" : [ {
        "x" : 624,
        "y" : 600
      } ]
    }, {
      "id" : 106882,
      "points" : [ {
        "x" : 635,
        "y" : 651
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 106883,
      "points" : [ {
        "x" : 711,
        "y" : 653
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 106879,
      "points" : [ {
        "x" : 571,
        "y" : 659
      }, {
        "x" : 590,
        "y" : 717
      }, {
        "x" : 680,
        "y" : 716
      } ]
    }, {
      "id" : 106884,
      "points" : [ {
        "x" : 677,
        "y" : 579
      } ]
    } ],
    "catalysts" : [ {
      "id" : 106880,
      "points" : [ {
        "x" : 624,
        "y" : 590
      }, {
        "x" : 651,
        "y" : 590
      } ]
    } ]
  }, {
    "id" : 106817,
    "reactomeId" : 10117949,
    "displayName" : "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 992,
      "y" : 849
    },
    "minX" : 978,
    "maxX" : 998,
    "minY" : 843,
    "maxY" : 883,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 994,
        "y" : 846
      },
      "to" : {
        "x" : 992,
        "y" : 849
      }
    }, {
      "from" : {
        "x" : 992,
        "y" : 849
      },
      "to" : {
        "x" : 978,
        "y" : 883
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 977,
        "y" : 875
      },
      "b" : {
        "x" : 978,
        "y" : 883
      },
      "c" : {
        "x" : 984,
        "y" : 878
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 984,
        "y" : 878
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 992,
        "y" : 849
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 992,
        "y" : 849
      }
    },
    "inputs" : [ {
      "id" : 106818,
      "points" : [ {
        "x" : 1108,
        "y" : 894
      } ]
    }, {
      "id" : 106815,
      "points" : [ {
        "x" : 1079,
        "y" : 588
      }, {
        "x" : 1019,
        "y" : 654
      } ]
    }, {
      "id" : 106819,
      "points" : [ {
        "x" : 1052,
        "y" : 781
      } ]
    } ],
    "outputs" : [ {
      "id" : 106820
    } ]
  }, {
    "id" : 106821,
    "reactomeId" : 10118039,
    "displayName" : "Activated type I receptor phosphorylates SMAD2/3 directly",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 953,
      "y" : 996
    },
    "minX" : 947,
    "maxX" : 959,
    "minY" : 973,
    "maxY" : 1015,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 953,
        "y" : 973
      },
      "to" : {
        "x" : 953,
        "y" : 996
      }
    }, {
      "from" : {
        "x" : 953,
        "y" : 996
      },
      "to" : {
        "x" : 953,
        "y" : 1015
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 947,
        "y" : 990
      },
      "b" : {
        "x" : 959,
        "y" : 1002
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 953,
        "y" : 996
      }
    },
    "inputs" : [ {
      "id" : 106820,
      "points" : [ {
        "x" : 966,
        "y" : 926
      } ]
    }, {
      "id" : 106822,
      "points" : [ {
        "x" : 993,
        "y" : 967
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 106823,
      "points" : [ {
        "x" : 947,
        "y" : 1056
      } ]
    }, {
      "id" : 106824,
      "points" : [ {
        "x" : 989,
        "y" : 1015
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 106820,
      "points" : [ {
        "x" : 955,
        "y" : 926
      }, {
        "x" : 922,
        "y" : 964
      } ]
    } ]
  }, {
    "id" : 106885,
    "reactomeId" : 10118023,
    "displayName" : "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 938,
      "y" : 1299
    },
    "minX" : 875,
    "maxX" : 986,
    "minY" : 1257,
    "maxY" : 1305,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 875,
        "y" : 1286
      },
      "to" : {
        "x" : 938,
        "y" : 1299
      }
    }, {
      "from" : {
        "x" : 938,
        "y" : 1299
      },
      "to" : {
        "x" : 986,
        "y" : 1257
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 983,
        "y" : 1265
      },
      "b" : {
        "x" : 986,
        "y" : 1257
      },
      "c" : {
        "x" : 978,
        "y" : 1259
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 978,
        "y" : 1259
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 932,
        "y" : 1293
      },
      "b" : {
        "x" : 944,
        "y" : 1305
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 938,
        "y" : 1299
      }
    },
    "inputs" : [ {
      "id" : 106826,
      "points" : [ {
        "x" : 828,
        "y" : 1274
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 106886,
      "points" : [ {
        "x" : 827,
        "y" : 1337
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 106887
    } ]
  }, {
    "id" : 106825,
    "reactomeId" : 10118029,
    "displayName" : "Phosphorylated SMAD2/3 dissociates from TGFBR",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 981,
      "y" : 1125
    },
    "minX" : 958,
    "maxX" : 987,
    "minY" : 1096,
    "maxY" : 1131,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 958,
        "y" : 1096
      },
      "to" : {
        "x" : 981,
        "y" : 1125
      }
    }, {
      "from" : {
        "x" : 981,
        "y" : 1125
      },
      "to" : {
        "x" : 983,
        "y" : 1129
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 981,
        "y" : 1125
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 981,
        "y" : 1125
      }
    },
    "inputs" : [ {
      "id" : 106823
    } ],
    "outputs" : [ {
      "id" : 106826,
      "points" : [ {
        "x" : 814,
        "y" : 1238
      } ]
    }, {
      "id" : 106827,
      "points" : [ {
        "x" : 1076,
        "y" : 1075
      } ]
    } ]
  }, {
    "id" : 106888,
    "reactomeId" : 10166094,
    "displayName" : "LTBP1, LTBP3 bind TGF-Beta",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 916,
      "y" : 285
    },
    "minX" : 856,
    "maxX" : 992,
    "minY" : 279,
    "maxY" : 291,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 856,
        "y" : 282
      },
      "to" : {
        "x" : 916,
        "y" : 285
      }
    }, {
      "from" : {
        "x" : 916,
        "y" : 285
      },
      "to" : {
        "x" : 992,
        "y" : 285
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 985,
        "y" : 289
      },
      "b" : {
        "x" : 992,
        "y" : 285
      },
      "c" : {
        "x" : 985,
        "y" : 281
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 985,
        "y" : 281
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 910,
        "y" : 279
      },
      "b" : {
        "x" : 922,
        "y" : 291
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 916,
        "y" : 285
      }
    },
    "inputs" : [ {
      "id" : 106889,
      "points" : [ {
        "x" : 780,
        "y" : 248
      } ]
    }, {
      "id" : 106890,
      "points" : [ {
        "x" : 822,
        "y" : 330
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 106891
    } ]
  }, {
    "id" : 106892,
    "reactomeId" : 10166098,
    "displayName" : "LTBP4 binds TGF-Beta-1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 449,
      "y" : 218
    },
    "minX" : 405,
    "maxX" : 515,
    "minY" : 212,
    "maxY" : 230,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 405,
        "y" : 230
      },
      "to" : {
        "x" : 449,
        "y" : 218
      }
    }, {
      "from" : {
        "x" : 449,
        "y" : 218
      },
      "to" : {
        "x" : 515,
        "y" : 215
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 508,
        "y" : 219
      },
      "b" : {
        "x" : 515,
        "y" : 215
      },
      "c" : {
        "x" : 508,
        "y" : 211
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 508,
        "y" : 211
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 449,
        "y" : 218
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 449,
        "y" : 218
      }
    },
    "inputs" : [ {
      "id" : 106802,
      "points" : [ {
        "x" : 381,
        "y" : 259
      } ]
    }, {
      "id" : 106893,
      "points" : [ {
        "x" : 330,
        "y" : 127
      } ]
    } ],
    "outputs" : [ {
      "id" : 106894
    } ]
  }, {
    "id" : 106828,
    "reactomeId" : 10164263,
    "displayName" : "SMURF1 binds phosphorylated PARD6A",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 525,
      "y" : 1039
    },
    "minX" : 519,
    "maxX" : 531,
    "minY" : 1027,
    "maxY" : 1067,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 525,
        "y" : 1027
      },
      "to" : {
        "x" : 525,
        "y" : 1039
      }
    }, {
      "from" : {
        "x" : 525,
        "y" : 1039
      },
      "to" : {
        "x" : 525,
        "y" : 1067
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 521,
        "y" : 1060
      },
      "b" : {
        "x" : 525,
        "y" : 1067
      },
      "c" : {
        "x" : 529,
        "y" : 1060
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 529,
        "y" : 1060
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 525,
        "y" : 1039
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 525,
        "y" : 1039
      }
    },
    "inputs" : [ {
      "id" : 106829,
      "points" : [ {
        "x" : 525,
        "y" : 1015
      } ]
    }, {
      "id" : 106830,
      "points" : [ {
        "x" : 603,
        "y" : 1028
      } ]
    } ],
    "outputs" : [ {
      "id" : 106831
    } ]
  }, {
    "id" : 106895,
    "reactomeId" : 10166072,
    "displayName" : "Latent TGF-beta-1 binds integrins",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1049,
      "y" : 98
    },
    "minX" : 987,
    "maxX" : 1107,
    "minY" : 85,
    "maxY" : 104,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 987,
        "y" : 100
      },
      "to" : {
        "x" : 1049,
        "y" : 98
      }
    }, {
      "from" : {
        "x" : 1049,
        "y" : 98
      },
      "to" : {
        "x" : 1107,
        "y" : 85
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1101,
        "y" : 90
      },
      "b" : {
        "x" : 1107,
        "y" : 85
      },
      "c" : {
        "x" : 1099,
        "y" : 83
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1099,
        "y" : 83
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1049,
        "y" : 98
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1049,
        "y" : 98
      }
    },
    "inputs" : [ {
      "id" : 106896,
      "points" : [ {
        "x" : 896,
        "y" : 76
      } ]
    }, {
      "id" : 106897,
      "points" : [ {
        "x" : 976,
        "y" : 176
      } ]
    } ],
    "outputs" : [ {
      "id" : 106898
    } ]
  }, {
    "id" : 106832,
    "reactomeId" : 10164265,
    "displayName" : "SMURF1 ubiquitinates RHOA",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 522,
      "y" : 1147
    },
    "minX" : 516,
    "maxX" : 528,
    "minY" : 1126,
    "maxY" : 1169,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 522,
        "y" : 1126
      },
      "to" : {
        "x" : 522,
        "y" : 1147
      }
    }, {
      "from" : {
        "x" : 522,
        "y" : 1147
      },
      "to" : {
        "x" : 523,
        "y" : 1169
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 519,
        "y" : 1162
      },
      "b" : {
        "x" : 523,
        "y" : 1169
      },
      "c" : {
        "x" : 527,
        "y" : 1162
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 527,
        "y" : 1162
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 522,
        "y" : 1147
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 522,
        "y" : 1147
      }
    },
    "inputs" : [ {
      "id" : 106831,
      "points" : [ {
        "x" : 523,
        "y" : 1111
      } ]
    }, {
      "id" : 106833,
      "points" : [ {
        "x" : 549,
        "y" : 1127
      } ]
    } ],
    "outputs" : [ {
      "id" : 106834
    } ]
  }, {
    "id" : 106899,
    "reactomeId" : 10166230,
    "displayName" : "Latent TGF-beta-3 binds integrins",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 705,
      "y" : 195
    },
    "minX" : 673,
    "maxX" : 741,
    "minY" : 186,
    "maxY" : 212,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 673,
        "y" : 212
      },
      "to" : {
        "x" : 705,
        "y" : 195
      }
    }, {
      "from" : {
        "x" : 705,
        "y" : 195
      },
      "to" : {
        "x" : 741,
        "y" : 186
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 735,
        "y" : 192
      },
      "b" : {
        "x" : 741,
        "y" : 186
      },
      "c" : {
        "x" : 733,
        "y" : 184
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 733,
        "y" : 184
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 705,
        "y" : 195
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 705,
        "y" : 195
      }
    },
    "inputs" : [ {
      "id" : 106900,
      "points" : [ {
        "x" : 642,
        "y" : 81
      } ]
    }, {
      "id" : 106901,
      "points" : [ {
        "x" : 538,
        "y" : 350
      } ]
    } ],
    "outputs" : [ {
      "id" : 106902
    } ]
  }, {
    "id" : 106835,
    "reactomeId" : 10164261,
    "displayName" : "Disassembly of tight junctions",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 589,
      "y" : 1251
    },
    "minX" : 546,
    "maxX" : 595,
    "minY" : 1215,
    "maxY" : 1270,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 546,
        "y" : 1215
      },
      "to" : {
        "x" : 589,
        "y" : 1251
      }
    }, {
      "from" : {
        "x" : 589,
        "y" : 1251
      },
      "to" : {
        "x" : 590,
        "y" : 1270
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 583,
        "y" : 1245
      },
      "b" : {
        "x" : 595,
        "y" : 1257
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 589,
        "y" : 1251
      }
    },
    "inputs" : [ {
      "id" : 106834
    } ]
  }, {
    "id" : 106836,
    "reactomeId" : 10118226,
    "displayName" : "I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1403,
      "y" : 644
    },
    "minX" : 1397,
    "maxX" : 1473,
    "minY" : 615,
    "maxY" : 650,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1402,
        "y" : 643
      },
      "to" : {
        "x" : 1403,
        "y" : 644
      }
    }, {
      "from" : {
        "x" : 1403,
        "y" : 644
      },
      "to" : {
        "x" : 1473,
        "y" : 615
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1468,
        "y" : 621
      },
      "b" : {
        "x" : 1473,
        "y" : 615
      },
      "c" : {
        "x" : 1465,
        "y" : 614
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1465,
        "y" : 614
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1403,
        "y" : 644
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1403,
        "y" : 644
      }
    },
    "inputs" : [ {
      "id" : 106837,
      "points" : [ {
        "x" : 1422,
        "y" : 713
      } ]
    }, {
      "id" : 106815,
      "points" : [ {
        "x" : 1153,
        "y" : 576
      } ]
    } ],
    "outputs" : [ {
      "id" : 106838
    } ]
  }, {
    "id" : 106903,
    "reactomeId" : 10166037,
    "displayName" : "Fibrillin-1 binds latent TGF-beta",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 169,
      "y" : 290
    },
    "minX" : 163,
    "maxX" : 175,
    "minY" : 242,
    "maxY" : 349,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 167,
        "y" : 242
      },
      "to" : {
        "x" : 169,
        "y" : 290
      }
    }, {
      "from" : {
        "x" : 169,
        "y" : 290
      },
      "to" : {
        "x" : 169,
        "y" : 349
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 165,
        "y" : 342
      },
      "b" : {
        "x" : 169,
        "y" : 349
      },
      "c" : {
        "x" : 173,
        "y" : 342
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 173,
        "y" : 342
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 169,
        "y" : 290
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 169,
        "y" : 290
      }
    },
    "inputs" : [ {
      "id" : 106904,
      "points" : [ {
        "x" : 127,
        "y" : 232
      } ]
    }, {
      "id" : 106905,
      "points" : [ {
        "x" : 179,
        "y" : 165
      } ]
    } ],
    "outputs" : [ {
      "id" : 106906
    } ]
  }, {
    "id" : 106839,
    "reactomeId" : 10163583,
    "displayName" : "STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1412,
      "y" : 593
    },
    "minX" : 1372,
    "maxX" : 1446,
    "minY" : 565,
    "maxY" : 627,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1378,
        "y" : 621
      },
      "to" : {
        "x" : 1412,
        "y" : 593
      }
    }, {
      "from" : {
        "x" : 1412,
        "y" : 593
      },
      "to" : {
        "x" : 1446,
        "y" : 565
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1443,
        "y" : 572
      },
      "b" : {
        "x" : 1446,
        "y" : 565
      },
      "c" : {
        "x" : 1438,
        "y" : 566
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1438,
        "y" : 566
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1412,
        "y" : 593
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1412,
        "y" : 593
      }
    },
    "inputs" : [ {
      "id" : 106837,
      "points" : [ {
        "x" : 1420,
        "y" : 713
      } ]
    }, {
      "id" : 106840,
      "points" : [ {
        "x" : 1317,
        "y" : 591
      } ]
    } ],
    "outputs" : [ {
      "id" : 106841
    } ]
  }, {
    "id" : 106842,
    "reactomeId" : 10120420,
    "displayName" : "SMAD7 binds to SMURF2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1484,
      "y" : 1314
    },
    "minX" : 1478,
    "maxX" : 1524,
    "minY" : 1308,
    "maxY" : 1320,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1484,
        "y" : 1312
      },
      "to" : {
        "x" : 1484,
        "y" : 1314
      }
    }, {
      "from" : {
        "x" : 1484,
        "y" : 1314
      },
      "to" : {
        "x" : 1524,
        "y" : 1317
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1517,
        "y" : 1320
      },
      "b" : {
        "x" : 1524,
        "y" : 1317
      },
      "c" : {
        "x" : 1517,
        "y" : 1312
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1517,
        "y" : 1312
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1484,
        "y" : 1314
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1484,
        "y" : 1314
      }
    },
    "inputs" : [ {
      "id" : 106843,
      "points" : [ {
        "x" : 1409,
        "y" : 1310
      } ]
    }, {
      "id" : 106844,
      "points" : [ {
        "x" : 1466,
        "y" : 1290
      } ]
    } ],
    "outputs" : [ {
      "id" : 106845
    } ]
  }, {
    "id" : 106846,
    "reactomeId" : 10164992,
    "displayName" : "Degradation of TGF-beta receptor complex",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1953,
      "y" : 632
    },
    "minX" : 1947,
    "maxX" : 1959,
    "minY" : 598,
    "maxY" : 725,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1953,
        "y" : 598
      },
      "to" : {
        "x" : 1953,
        "y" : 632
      }
    }, {
      "from" : {
        "x" : 1953,
        "y" : 632
      },
      "to" : {
        "x" : 1955,
        "y" : 725
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1947,
        "y" : 626
      },
      "b" : {
        "x" : 1959,
        "y" : 638
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1953,
        "y" : 632
      }
    },
    "inputs" : [ {
      "id" : 106847
    } ]
  }, {
    "id" : 106848,
    "reactomeId" : 10165066,
    "displayName" : "SMURF2 binds SMAD2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1124,
      "y" : 698
    },
    "minX" : 1118,
    "maxX" : 1166,
    "minY" : 692,
    "maxY" : 721,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1123,
        "y" : 698
      },
      "to" : {
        "x" : 1124,
        "y" : 698
      }
    }, {
      "from" : {
        "x" : 1124,
        "y" : 698
      },
      "to" : {
        "x" : 1166,
        "y" : 721
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1158,
        "y" : 721
      },
      "b" : {
        "x" : 1166,
        "y" : 721
      },
      "c" : {
        "x" : 1162,
        "y" : 714
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1162,
        "y" : 714
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1124,
        "y" : 698
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1124,
        "y" : 698
      }
    },
    "inputs" : [ {
      "id" : 106849,
      "points" : [ {
        "x" : 1127,
        "y" : 717
      } ]
    }, {
      "id" : 106850,
      "points" : [ {
        "x" : 1144,
        "y" : 685
      } ]
    } ],
    "outputs" : [ {
      "id" : 106851
    } ]
  }, {
    "id" : 106852,
    "reactomeId" : 10165068,
    "displayName" : "Degradation of ubiquitinated SMAD2",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1330,
      "y" : 759
    },
    "minX" : 1324,
    "maxX" : 1336,
    "minY" : 746,
    "maxY" : 780,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1331,
        "y" : 746
      },
      "to" : {
        "x" : 1330,
        "y" : 759
      }
    }, {
      "from" : {
        "x" : 1330,
        "y" : 759
      },
      "to" : {
        "x" : 1331,
        "y" : 780
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1324,
        "y" : 753
      },
      "b" : {
        "x" : 1336,
        "y" : 765
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1330,
        "y" : 759
      }
    },
    "inputs" : [ {
      "id" : 106853
    } ]
  }, {
    "id" : 106854,
    "reactomeId" : 10118237,
    "displayName" : "SMURF2 ubiquitinates SMAD2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1257,
      "y" : 740
    },
    "minX" : 1240,
    "maxX" : 1275,
    "minY" : 734,
    "maxY" : 746,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1240,
        "y" : 740
      },
      "to" : {
        "x" : 1257,
        "y" : 740
      }
    }, {
      "from" : {
        "x" : 1257,
        "y" : 740
      },
      "to" : {
        "x" : 1275,
        "y" : 736
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1251,
        "y" : 734
      },
      "b" : {
        "x" : 1263,
        "y" : 746
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1257,
        "y" : 740
      }
    },
    "inputs" : [ {
      "id" : 106851,
      "points" : [ {
        "x" : 1229,
        "y" : 740
      } ]
    }, {
      "id" : 106855,
      "points" : [ {
        "x" : 1245,
        "y" : 771
      } ]
    } ],
    "outputs" : [ {
      "id" : 106853,
      "points" : [ {
        "x" : 1291,
        "y" : 734
      } ]
    }, {
      "id" : 106850,
      "points" : [ {
        "x" : 1179,
        "y" : 685
      } ]
    } ],
    "catalysts" : [ {
      "id" : 106851,
      "points" : [ {
        "x" : 1229,
        "y" : 726
      }, {
        "x" : 1236,
        "y" : 721
      } ]
    } ]
  }, {
    "id" : 106856,
    "reactomeId" : 10165278,
    "displayName" : "PMEPA1 sequesters phosphorylated SMAD2/3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1009,
      "y" : 1168
    },
    "minX" : 914,
    "maxX" : 1098,
    "minY" : 1143,
    "maxY" : 1199,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 920,
        "y" : 1193
      },
      "to" : {
        "x" : 1009,
        "y" : 1168
      }
    }, {
      "from" : {
        "x" : 1009,
        "y" : 1168
      },
      "to" : {
        "x" : 1098,
        "y" : 1143
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1092,
        "y" : 1149
      },
      "b" : {
        "x" : 1098,
        "y" : 1143
      },
      "c" : {
        "x" : 1090,
        "y" : 1141
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1090,
        "y" : 1141
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1009,
        "y" : 1168
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1009,
        "y" : 1168
      }
    },
    "inputs" : [ {
      "id" : 106826,
      "points" : [ {
        "x" : 820,
        "y" : 1238
      } ]
    }, {
      "id" : 106857,
      "points" : [ {
        "x" : 1048,
        "y" : 1124
      } ]
    } ],
    "outputs" : [ {
      "id" : 106858
    } ]
  }, {
    "id" : 106859,
    "reactomeId" : 10165284,
    "displayName" : "PMEPA1 sequesters unphosphorylated SMAD2/3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1088,
      "y" : 669
    },
    "minX" : 1082,
    "maxX" : 1135,
    "minY" : 647,
    "maxY" : 675,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1089,
        "y" : 669
      },
      "to" : {
        "x" : 1088,
        "y" : 669
      }
    }, {
      "from" : {
        "x" : 1088,
        "y" : 669
      },
      "to" : {
        "x" : 1135,
        "y" : 647
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1130,
        "y" : 654
      },
      "b" : {
        "x" : 1135,
        "y" : 647
      },
      "c" : {
        "x" : 1127,
        "y" : 646
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1127,
        "y" : 646
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1088,
        "y" : 669
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1088,
        "y" : 669
      }
    },
    "inputs" : [ {
      "id" : 106860,
      "points" : [ {
        "x" : 1096,
        "y" : 633
      } ]
    }, {
      "id" : 106819,
      "points" : [ {
        "x" : 1065,
        "y" : 747
      } ]
    } ],
    "outputs" : [ {
      "id" : 106861
    } ]
  }, {
    "id" : 106797,
    "reactomeId" : 10117972,
    "displayName" : "Latent TGF-beta-1 is cleaved by FURIN",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 156,
      "y" : 651
    },
    "minX" : 126,
    "maxX" : 209,
    "minY" : 645,
    "maxY" : 657,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 126,
        "y" : 649
      },
      "to" : {
        "x" : 156,
        "y" : 651
      }
    }, {
      "from" : {
        "x" : 156,
        "y" : 651
      },
      "to" : {
        "x" : 209,
        "y" : 652
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 202,
        "y" : 656
      },
      "b" : {
        "x" : 209,
        "y" : 652
      },
      "c" : {
        "x" : 202,
        "y" : 648
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 202,
        "y" : 648
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 150,
        "y" : 645
      },
      "b" : {
        "x" : 162,
        "y" : 657
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 156,
        "y" : 651
      }
    },
    "inputs" : [ {
      "id" : 106798
    } ],
    "outputs" : [ {
      "id" : 106799
    } ],
    "catalysts" : [ {
      "id" : 106800,
      "points" : [ {
        "x" : 185,
        "y" : 575
      } ]
    } ]
  }, {
    "id" : 106862,
    "reactomeId" : 10165293,
    "displayName" : "SMAD3 binds STUB1 (CHIP)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1144,
      "y" : 826
    },
    "minX" : 1138,
    "maxX" : 1168,
    "minY" : 820,
    "maxY" : 837,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1143,
        "y" : 827
      },
      "to" : {
        "x" : 1144,
        "y" : 826
      }
    }, {
      "from" : {
        "x" : 1144,
        "y" : 826
      },
      "to" : {
        "x" : 1168,
        "y" : 837
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1160,
        "y" : 838
      },
      "b" : {
        "x" : 1168,
        "y" : 837
      },
      "c" : {
        "x" : 1163,
        "y" : 830
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1163,
        "y" : 830
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1144,
        "y" : 826
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1144,
        "y" : 826
      }
    },
    "inputs" : [ {
      "id" : 106863,
      "points" : [ {
        "x" : 1157,
        "y" : 808
      } ]
    }, {
      "id" : 106864,
      "points" : [ {
        "x" : 1128,
        "y" : 835
      } ]
    } ],
    "outputs" : [ {
      "id" : 106865
    } ]
  }, {
    "id" : 106801,
    "reactomeId" : 10120049,
    "displayName" : "Secretion and activation of the latent large complex of TGF-beta-1",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 369,
      "y" : 571
    },
    "minX" : 277,
    "maxX" : 375,
    "minY" : 288,
    "maxY" : 634,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 277,
        "y" : 634
      },
      "to" : {
        "x" : 369,
        "y" : 571
      }
    }, {
      "from" : {
        "x" : 369,
        "y" : 571
      },
      "to" : {
        "x" : 372,
        "y" : 288
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 376,
        "y" : 295
      },
      "b" : {
        "x" : 372,
        "y" : 288
      },
      "c" : {
        "x" : 368,
        "y" : 295
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 368,
        "y" : 295
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 363,
        "y" : 565
      },
      "b" : {
        "x" : 375,
        "y" : 577
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 369,
        "y" : 571
      }
    },
    "inputs" : [ {
      "id" : 106799
    } ],
    "outputs" : [ {
      "id" : 106802
    } ]
  }, {
    "id" : 106803,
    "reactomeId" : 10118035,
    "displayName" : "Dimeric TGF-beta-1 binds to the receptor",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 644,
      "y" : 512
    },
    "minX" : 613,
    "maxX" : 675,
    "minY" : 506,
    "maxY" : 518,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 613,
        "y" : 518
      },
      "to" : {
        "x" : 644,
        "y" : 512
      }
    }, {
      "from" : {
        "x" : 644,
        "y" : 512
      },
      "to" : {
        "x" : 675,
        "y" : 509
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 668,
        "y" : 514
      },
      "b" : {
        "x" : 675,
        "y" : 509
      },
      "c" : {
        "x" : 668,
        "y" : 506
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 668,
        "y" : 506
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 644,
        "y" : 512
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 644,
        "y" : 512
      }
    },
    "inputs" : [ {
      "id" : 106804,
      "points" : [ {
        "x" : 573,
        "y" : 533
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 106805,
      "points" : [ {
        "x" : 613,
        "y" : 448
      } ]
    } ],
    "outputs" : [ {
      "id" : 106806
    } ],
    "inhibitors" : [ {
      "id" : 106808,
      "points" : [ {
        "x" : 583,
        "y" : 488
      } ]
    } ],
    "activators" : [ {
      "id" : 106807,
      "points" : [ {
        "x" : 846,
        "y" : 483
      }, {
        "x" : 690,
        "y" : 450
      } ]
    } ]
  }, {
    "id" : 106866,
    "reactomeId" : 10165291,
    "displayName" : "STUB1 (CHIP) ubiquitinates SMAD3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1262,
      "y" : 843
    },
    "minX" : 1245,
    "maxX" : 1278,
    "minY" : 837,
    "maxY" : 849,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1245,
        "y" : 843
      },
      "to" : {
        "x" : 1262,
        "y" : 843
      }
    }, {
      "from" : {
        "x" : 1262,
        "y" : 843
      },
      "to" : {
        "x" : 1278,
        "y" : 843
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1256,
        "y" : 837
      },
      "b" : {
        "x" : 1268,
        "y" : 849
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1262,
        "y" : 843
      }
    },
    "inputs" : [ {
      "id" : 106865,
      "points" : [ {
        "x" : 1227,
        "y" : 845
      } ]
    }, {
      "id" : 106855,
      "points" : [ {
        "x" : 1246,
        "y" : 805
      } ]
    } ],
    "outputs" : [ {
      "id" : 106867,
      "points" : [ {
        "x" : 1294,
        "y" : 843
      } ]
    }, {
      "id" : 106864,
      "points" : [ {
        "x" : 1140,
        "y" : 857
      }, {
        "x" : 1232,
        "y" : 890
      } ]
    } ],
    "catalysts" : [ {
      "id" : 106865,
      "points" : [ {
        "x" : 1227,
        "y" : 856
      }, {
        "x" : 1244,
        "y" : 863
      } ]
    } ]
  }, {
    "id" : 106869,
    "reactomeId" : 10165308,
    "displayName" : "MTMR4 binds phosphorylated SMAD2/3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 868,
      "y" : 1095
    },
    "minX" : 834,
    "maxX" : 889,
    "minY" : 1060,
    "maxY" : 1119,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 889,
        "y" : 1119
      },
      "to" : {
        "x" : 868,
        "y" : 1095
      }
    }, {
      "from" : {
        "x" : 868,
        "y" : 1095
      },
      "to" : {
        "x" : 834,
        "y" : 1060
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 842,
        "y" : 1062
      },
      "b" : {
        "x" : 834,
        "y" : 1060
      },
      "c" : {
        "x" : 836,
        "y" : 1068
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 836,
        "y" : 1068
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 868,
        "y" : 1095
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 868,
        "y" : 1095
      }
    },
    "inputs" : [ {
      "id" : 106870,
      "points" : [ {
        "x" : 850,
        "y" : 1110
      } ]
    }, {
      "id" : 106826,
      "points" : [ {
        "x" : 805,
        "y" : 1238
      } ]
    } ],
    "outputs" : [ {
      "id" : 106871
    } ]
  }, {
    "id" : 106868,
    "reactomeId" : 10165295,
    "displayName" : "Degradation of ubiquitinated SMAD3",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1332,
      "y" : 814
    },
    "minX" : 1326,
    "maxX" : 1338,
    "minY" : 795,
    "maxY" : 830,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1332,
        "y" : 830
      },
      "to" : {
        "x" : 1332,
        "y" : 814
      }
    }, {
      "from" : {
        "x" : 1332,
        "y" : 814
      },
      "to" : {
        "x" : 1331,
        "y" : 795
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1326,
        "y" : 808
      },
      "b" : {
        "x" : 1338,
        "y" : 820
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1332,
        "y" : 814
      }
    },
    "inputs" : [ {
      "id" : 106867
    } ]
  }, {
    "id" : 106809,
    "reactomeId" : 10117995,
    "displayName" : "TGFBR2 recruits TGFBR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 834,
      "y" : 536
    },
    "minX" : 818,
    "maxX" : 845,
    "minY" : 530,
    "maxY" : 584,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 818,
        "y" : 532
      },
      "to" : {
        "x" : 834,
        "y" : 536
      }
    }, {
      "from" : {
        "x" : 834,
        "y" : 536
      },
      "to" : {
        "x" : 845,
        "y" : 584
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 828,
        "y" : 530
      },
      "b" : {
        "x" : 840,
        "y" : 542
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 834,
        "y" : 536
      }
    },
    "inputs" : [ {
      "id" : 106806,
      "points" : [ {
        "x" : 806,
        "y" : 526
      } ]
    }, {
      "id" : 106810,
      "points" : [ {
        "x" : 800,
        "y" : 569
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 106811,
      "points" : [ {
        "x" : 868,
        "y" : 571
      } ]
    }, {
      "id" : 106812,
      "points" : [ {
        "x" : 856,
        "y" : 633
      } ],
      "stoichiometry" : 2
    } ],
    "activators" : [ {
      "id" : 106807,
      "points" : [ {
        "x" : 873,
        "y" : 517
      } ]
    } ]
  }, {
    "id" : 106872,
    "reactomeId" : 10165306,
    "displayName" : "MTMR4 dephosphorylates SMAD2/3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 813,
      "y" : 969
    },
    "minX" : 807,
    "maxX" : 826,
    "minY" : 948,
    "maxY" : 996,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 814,
        "y" : 996
      },
      "to" : {
        "x" : 813,
        "y" : 969
      }
    }, {
      "from" : {
        "x" : 813,
        "y" : 969
      },
      "to" : {
        "x" : 826,
        "y" : 948
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 807,
        "y" : 963
      },
      "b" : {
        "x" : 819,
        "y" : 975
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 813,
        "y" : 969
      }
    },
    "inputs" : [ {
      "id" : 106871,
      "points" : [ {
        "x" : 816,
        "y" : 1017
      } ]
    }, {
      "id" : 106873,
      "points" : [ {
        "x" : 809,
        "y" : 995
      } ]
    } ],
    "outputs" : [ {
      "id" : 106870,
      "points" : [ {
        "x" : 800,
        "y" : 1092
      }, {
        "x" : 729,
        "y" : 1047
      }, {
        "x" : 736,
        "y" : 947
      } ]
    }, {
      "id" : 106819,
      "points" : [ {
        "x" : 1023,
        "y" : 764
      }, {
        "x" : 986,
        "y" : 764
      } ]
    }, {
      "id" : 106874,
      "points" : [ {
        "x" : 786,
        "y" : 925
      } ]
    } ],
    "catalysts" : [ {
      "id" : 106871,
      "points" : [ {
        "x" : 830,
        "y" : 1017
      }, {
        "x" : 844,
        "y" : 999
      } ]
    } ]
  }, {
    "id" : 106875,
    "reactomeId" : 10118213,
    "displayName" : "BAMBI interferes with the interaction of type I receptor with type II receptor",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1352,
      "y" : 609
    },
    "minX" : 1329,
    "maxX" : 1370,
    "minY" : 568,
    "maxY" : 656,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1335,
        "y" : 650
      },
      "to" : {
        "x" : 1352,
        "y" : 609
      }
    }, {
      "from" : {
        "x" : 1352,
        "y" : 609
      },
      "to" : {
        "x" : 1370,
        "y" : 568
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1371,
        "y" : 576
      },
      "b" : {
        "x" : 1370,
        "y" : 568
      },
      "c" : {
        "x" : 1364,
        "y" : 573
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1364,
        "y" : 573
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1352,
        "y" : 609
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1352,
        "y" : 609
      }
    },
    "inputs" : [ {
      "id" : 106837,
      "points" : [ {
        "x" : 1412,
        "y" : 713
      } ]
    }, {
      "id" : 106876,
      "points" : [ {
        "x" : 1297,
        "y" : 678
      } ]
    }, {
      "id" : 106815,
      "points" : [ {
        "x" : 1153,
        "y" : 581
      } ]
    } ],
    "outputs" : [ {
      "id" : 106877
    } ]
  }, {
    "id" : 106813,
    "reactomeId" : 10117958,
    "displayName" : "TGFBR2 phosphorylates TGFBR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1000,
      "y" : 555
    },
    "minX" : 980,
    "maxX" : 1019,
    "minY" : 549,
    "maxY" : 561,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 980,
        "y" : 553
      },
      "to" : {
        "x" : 1000,
        "y" : 555
      }
    }, {
      "from" : {
        "x" : 1000,
        "y" : 555
      },
      "to" : {
        "x" : 1019,
        "y" : 556
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 994,
        "y" : 549
      },
      "b" : {
        "x" : 1006,
        "y" : 561
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1000,
        "y" : 555
      }
    },
    "inputs" : [ {
      "id" : 106811,
      "points" : [ {
        "x" : 960,
        "y" : 551
      } ]
    }, {
      "id" : 106814,
      "points" : [ {
        "x" : 970,
        "y" : 590
      } ],
      "stoichiometry" : 12
    } ],
    "outputs" : [ {
      "id" : 106815,
      "points" : [ {
        "x" : 1044,
        "y" : 558
      } ]
    }, {
      "id" : 106816,
      "points" : [ {
        "x" : 1024,
        "y" : 592
      } ],
      "stoichiometry" : 12
    } ],
    "catalysts" : [ {
      "id" : 106811,
      "points" : [ {
        "x" : 960,
        "y" : 529
      }, {
        "x" : 981,
        "y" : 518
      } ]
    } ]
  }, {
    "id" : 106878,
    "reactomeId" : 10173028,
    "displayName" : "CBL binds TGFBR2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 538,
      "y" : 577
    },
    "minX" : 520,
    "maxX" : 559,
    "minY" : 571,
    "maxY" : 583,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 520,
        "y" : 575
      },
      "to" : {
        "x" : 538,
        "y" : 577
      }
    }, {
      "from" : {
        "x" : 538,
        "y" : 577
      },
      "to" : {
        "x" : 559,
        "y" : 582
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 551,
        "y" : 584
      },
      "b" : {
        "x" : 559,
        "y" : 582
      },
      "c" : {
        "x" : 553,
        "y" : 577
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 553,
        "y" : 577
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 538,
        "y" : 577
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 538,
        "y" : 577
      }
    },
    "inputs" : [ {
      "id" : 106804,
      "points" : [ {
        "x" : 532,
        "y" : 559
      } ]
    }, {
      "id" : 106879,
      "points" : [ {
        "x" : 559,
        "y" : 629
      } ]
    } ],
    "outputs" : [ {
      "id" : 106880
    } ]
  } ],
  "compartments" : [ {
    "id" : 106931,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1046,
      "y" : 40
    },
    "minX" : 518,
    "maxX" : 1574,
    "minY" : 0,
    "maxY" : 81,
    "prop" : {
      "x" : 518,
      "y" : 0,
      "width" : 1056,
      "height" : 81
    },
    "textPosition" : {
      "x" : 555,
      "y" : 20
    },
    "insets" : {
      "x" : 528,
      "y" : 10,
      "width" : 1036,
      "height" : 61
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 106896, 106898, 106900, 106941 ]
  }, {
    "id" : 106907,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1334,
      "y" : 998
    },
    "minX" : 497,
    "maxX" : 2171,
    "minY" : 509,
    "maxY" : 1487,
    "prop" : {
      "x" : 497,
      "y" : 509,
      "width" : 1674,
      "height" : 978
    },
    "textPosition" : {
      "x" : 585,
      "y" : 1412
    },
    "insets" : {
      "x" : 507,
      "y" : 519,
      "width" : 1654,
      "height" : 958
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 106908, 106806, 106811, 106815, 106813, 106814, 106816, 106817, 106819, 106803, 106809, 106911, 106886, 106832, 106835, 106833, 106828, 106840, 106836, 106837, 106838, 106839, 106841, 106826, 106915, 106919, 106934, 106935, 106847, 106846, 106923, 106924, 106936, 106851, 106853, 106848, 106852, 106855, 106854, 106850, 106810, 106812, 106859, 106860, 106861, 106862, 106863, 106937, 106864, 106865, 106866, 106867, 106868, 106874, 106928, 106849, 106938, 106830, 106804, 106875, 106876, 106877, 106825, 106878, 106879, 106880, 106881, 106882, 106883, 106829, 106831, 106834, 106822, 106887, 106885, 106822, 106856, 106884, 106807 ]
  }, {
    "id" : 106909,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 188,
      "y" : 995
    },
    "minX" : 0,
    "maxX" : 376,
    "minY" : 509,
    "maxY" : 1482,
    "prop" : {
      "x" : 0,
      "y" : 509,
      "width" : 376,
      "height" : 973
    },
    "textPosition" : {
      "x" : 166,
      "y" : 1409
    },
    "insets" : {
      "x" : 10,
      "y" : 519,
      "width" : 356,
      "height" : 953
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 106910, 106801 ]
  }, {
    "id" : 106908,
    "reactomeId" : 17941,
    "displayName" : "early endosome",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1063,
      "y" : 1007
    },
    "minX" : 800,
    "maxX" : 1326,
    "minY" : 897,
    "maxY" : 1118,
    "prop" : {
      "x" : 800,
      "y" : 897,
      "width" : 526,
      "height" : 221
    },
    "textPosition" : {
      "x" : 1041,
      "y" : 981
    },
    "insets" : {
      "x" : 810,
      "y" : 907,
      "width" : 506,
      "height" : 201
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 106820, 106823, 106827, 106821, 106824, 106857, 106858, 106871, 106870, 106869, 106872, 106873, 106929, 106818, 106822 ]
  }, {
    "id" : 106911,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1460,
      "y" : 1306
    },
    "minX" : 1071,
    "maxX" : 1849,
    "minY" : 1166,
    "maxY" : 1446,
    "prop" : {
      "x" : 1071,
      "y" : 1166,
      "width" : 778,
      "height" : 280
    },
    "textPosition" : {
      "x" : 1087,
      "y" : 1362
    },
    "insets" : {
      "x" : 1081,
      "y" : 1176,
      "width" : 758,
      "height" : 260
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 106912, 106932, 106843, 106844, 106842, 106845, 106933 ]
  }, {
    "id" : 106910,
    "reactomeId" : 17963,
    "displayName" : "Golgi lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 182,
      "y" : 722
    },
    "minX" : 30,
    "maxX" : 334,
    "minY" : 560,
    "maxY" : 884,
    "prop" : {
      "x" : 30,
      "y" : 560,
      "width" : 304,
      "height" : 324
    },
    "textPosition" : {
      "x" : 198,
      "y" : 832
    },
    "insets" : {
      "x" : 40,
      "y" : 570,
      "width" : 284,
      "height" : 304
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 106800, 106797, 106798, 106799 ]
  } ],
  "notes" : [ {
    "id" : 106929,
    "displayName" : "early endosome membrane",
    "renderableClass" : "Note",
    "position" : {
      "x" : 885,
      "y" : 992
    },
    "minX" : 848,
    "maxX" : 922,
    "minY" : 970,
    "maxY" : 1014,
    "prop" : {
      "x" : 848,
      "y" : 970,
      "width" : 74,
      "height" : 44
    },
    "textPosition" : {
      "x" : 846,
      "y" : 961
    }
  }, {
    "id" : 106915,
    "displayName" : "Disassembly of Tight Junctions",
    "renderableClass" : "Note",
    "position" : {
      "x" : 626,
      "y" : 1284
    },
    "minX" : 532,
    "maxX" : 720,
    "minY" : 1276,
    "maxY" : 1292,
    "prop" : {
      "x" : 532,
      "y" : 1276,
      "width" : 188,
      "height" : 16
    },
    "textPosition" : {
      "x" : 556,
      "y" : 1267
    }
  }, {
    "id" : 106923,
    "displayName" : "Degradation of TGFBR complex",
    "renderableClass" : "Note",
    "position" : {
      "x" : 1954,
      "y" : 749
    },
    "minX" : 1898,
    "maxX" : 2011,
    "minY" : 735,
    "maxY" : 764,
    "prop" : {
      "x" : 1898,
      "y" : 735,
      "width" : 113,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1901,
      "y" : 732
    }
  }, {
    "id" : 106924,
    "displayName" : "Degradation",
    "renderableClass" : "Note",
    "position" : {
      "x" : 1331,
      "y" : 786
    },
    "minX" : 1284,
    "maxX" : 1378,
    "minY" : 776,
    "maxY" : 796,
    "prop" : {
      "x" : 1284,
      "y" : 776,
      "width" : 94,
      "height" : 20
    },
    "textPosition" : {
      "x" : 1288,
      "y" : 776
    }
  } ],
  "links" : [ {
    "id" : 106933,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1386,
      "y" : 1277
    },
    "minX" : 1380,
    "maxX" : 1392,
    "minY" : 1259,
    "maxY" : 1296,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1390,
        "y" : 1259
      },
      "to" : {
        "x" : 1382,
        "y" : 1296
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1380,
        "y" : 1288
      },
      "b" : {
        "x" : 1382,
        "y" : 1296
      },
      "c" : {
        "x" : 1387,
        "y" : 1290
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1387,
        "y" : 1290
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1380,
        "y" : 1271
      },
      "b" : {
        "x" : 1392,
        "y" : 1283
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1386,
        "y" : 1277
      }
    },
    "inputs" : [ {
      "id" : 106912
    } ],
    "outputs" : [ {
      "id" : 106843
    } ]
  }, {
    "id" : 106932,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1144,
      "y" : 1230
    },
    "minX" : 1067,
    "maxX" : 1222,
    "minY" : 1224,
    "maxY" : 1236,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1067,
        "y" : 1231
      },
      "to" : {
        "x" : 1222,
        "y" : 1230
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1215,
        "y" : 1234
      },
      "b" : {
        "x" : 1222,
        "y" : 1230
      },
      "c" : {
        "x" : 1215,
        "y" : 1226
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1215,
        "y" : 1226
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1138,
        "y" : 1224
      },
      "b" : {
        "x" : 1150,
        "y" : 1236
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1144,
        "y" : 1230
      }
    },
    "inputs" : [ {
      "id" : 106887
    } ],
    "outputs" : [ {
      "id" : 106912
    } ]
  }, {
    "id" : 106937,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1113,
      "y" : 785
    },
    "minX" : 1092,
    "maxX" : 1135,
    "minY" : 779,
    "maxY" : 791,
    "segments" : [ {
      "from" : {
        "x" : 1135,
        "y" : 790
      },
      "to" : {
        "x" : 1092,
        "y" : 781
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1107,
        "y" : 779
      },
      "b" : {
        "x" : 1119,
        "y" : 791
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1113,
        "y" : 785
      }
    },
    "inputs" : [ {
      "id" : 106863
    } ],
    "outputs" : [ {
      "id" : 106819
    } ]
  }, {
    "id" : 106939,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 645,
      "y" : 299
    },
    "minX" : 549,
    "maxX" : 742,
    "minY" : 248,
    "maxY" : 350,
    "segments" : [ {
      "from" : {
        "x" : 549,
        "y" : 350
      },
      "to" : {
        "x" : 742,
        "y" : 248
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 639,
        "y" : 293
      },
      "b" : {
        "x" : 651,
        "y" : 305
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 645,
        "y" : 299
      }
    },
    "inputs" : [ {
      "id" : 106901
    } ],
    "outputs" : [ {
      "id" : 106889
    } ]
  }, {
    "id" : 106938,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1089,
      "y" : 742
    },
    "minX" : 1078,
    "maxX" : 1101,
    "minY" : 736,
    "maxY" : 748,
    "segments" : [ {
      "from" : {
        "x" : 1101,
        "y" : 738
      },
      "to" : {
        "x" : 1078,
        "y" : 747
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1083,
        "y" : 736
      },
      "b" : {
        "x" : 1095,
        "y" : 748
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1089,
        "y" : 742
      }
    },
    "inputs" : [ {
      "id" : 106849
    } ],
    "outputs" : [ {
      "id" : 106819
    } ]
  }, {
    "id" : 106941,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 752,
      "y" : 60
    },
    "minX" : 721,
    "maxX" : 784,
    "minY" : 54,
    "maxY" : 66,
    "segments" : [ {
      "from" : {
        "x" : 721,
        "y" : 61
      },
      "to" : {
        "x" : 784,
        "y" : 60
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 746,
        "y" : 54
      },
      "b" : {
        "x" : 758,
        "y" : 66
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 752,
        "y" : 60
      }
    },
    "inputs" : [ {
      "id" : 106900
    } ],
    "outputs" : [ {
      "id" : 106896
    } ]
  }, {
    "id" : 106940,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 564,
      "y" : 251
    },
    "minX" : 419,
    "maxX" : 710,
    "minY" : 235,
    "maxY" : 268,
    "segments" : [ {
      "from" : {
        "x" : 419,
        "y" : 268
      },
      "to" : {
        "x" : 710,
        "y" : 235
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 558,
        "y" : 245
      },
      "b" : {
        "x" : 570,
        "y" : 257
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 564,
        "y" : 251
      }
    },
    "inputs" : [ {
      "id" : 106802
    } ],
    "outputs" : [ {
      "id" : 106889
    } ]
  }, {
    "id" : 106943,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 496,
      "y" : 248
    },
    "minX" : 215,
    "maxX" : 777,
    "minY" : 155,
    "maxY" : 341,
    "segments" : [ {
      "from" : {
        "x" : 215,
        "y" : 155
      },
      "to" : {
        "x" : 777,
        "y" : 341
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 490,
        "y" : 242
      },
      "b" : {
        "x" : 502,
        "y" : 254
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 496,
        "y" : 248
      }
    },
    "inputs" : [ {
      "id" : 106905
    } ],
    "outputs" : [ {
      "id" : 106890
    } ]
  }, {
    "id" : 106942,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 255,
      "y" : 129
    },
    "minX" : 215,
    "maxX" : 296,
    "minY" : 119,
    "maxY" : 139,
    "segments" : [ {
      "from" : {
        "x" : 296,
        "y" : 119
      },
      "to" : {
        "x" : 215,
        "y" : 139
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 249,
        "y" : 123
      },
      "b" : {
        "x" : 261,
        "y" : 135
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 255,
        "y" : 129
      }
    },
    "inputs" : [ {
      "id" : 106893
    } ],
    "outputs" : [ {
      "id" : 106905
    } ]
  } ],
  "shadows" : [ {
    "id" : 106945,
    "reactomeId" : 10224393,
    "displayName" : "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 533,
      "y" : 1122
    },
    "minX" : 390,
    "maxX" : 676,
    "minY" : 965,
    "maxY" : 1280,
    "prop" : {
      "x" : 390,
      "y" : 965,
      "width" : 286,
      "height" : 315
    },
    "points" : [ {
      "x" : 390,
      "y" : 965
    }, {
      "x" : 676,
      "y" : 965
    }, {
      "x" : 676,
      "y" : 1280
    }, {
      "x" : 390,
      "y" : 1280
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 106944,
    "reactomeId" : 10222911,
    "displayName" : "TGF-beta receptor signaling activates SMADs",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1027,
      "y" : 705
    },
    "minX" : 36,
    "maxX" : 2018,
    "minY" : 37,
    "maxY" : 1373,
    "prop" : {
      "x" : 676,
      "y" : 965,
      "width" : 1342,
      "height" : 315
    },
    "points" : [ {
      "x" : 36,
      "y" : 37
    }, {
      "x" : 2018,
      "y" : 37
    }, {
      "x" : 2018,
      "y" : 1373
    }, {
      "x" : 36,
      "y" : 1373
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 2171,
  "minY" : 0,
  "maxY" : 1487,
  "disease" : false
}