{ "dbId" : 10222491, "stableId" : "R-RNO-163685", "displayName" : "Integration of energy metabolism", "nodes" : [ { "id" : 100353, "reactomeId" : 10136141, "displayName" : "Adenylate Cyclase V or VI", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 967, "y" : 1729 }, "minX" : 903, "maxX" : 1033, "minY" : 1695, "maxY" : 1748, "prop" : { "x" : 903, "y" : 1711, "width" : 129, "height" : 37 }, "textPosition" : { "x" : 905, "y" : 1712 }, "connectors" : [ { "edgeId" : 100352, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1002, "y" : 1705 }, "to" : { "x" : 1033, "y" : 1695 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100354, "reactomeId" : 10136143, "displayName" : "Adenylate cyclase type V or VI: G-protein beta gamma Complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1161, "y" : 1722 }, "minX" : 1096, "maxX" : 1233, "minY" : 1684, "maxY" : 1755, "prop" : { "x" : 1096, "y" : 1690, "width" : 131, "height" : 65 }, "textPosition" : { "x" : 1099, "y" : 1692 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1227, "y" : 1690 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1227, "y" : 1690 } } }, "connectors" : [ { "edgeId" : 100352, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100357, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2187, "y" : 1667 }, "minX" : 2139, "maxX" : 2210, "minY" : 1651, "maxY" : 1696, "prop" : { "x" : 2166, "y" : 1652, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 2170, "y" : 1657 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2204, "y" : 1657 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2204, "y" : 1657 } } }, "connectors" : [ { "edgeId" : 100355, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2163, "y" : 1679 }, "to" : { "x" : 2139, "y" : 1696 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 100356, "reactomeId" : 179856, "displayName" : "PI(4,5)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2192, "y" : 1722 }, "minX" : 2139, "maxX" : 2228, "minY" : 1696, "maxY" : 1738, "prop" : { "x" : 2157, "y" : 1707, "width" : 70, "height" : 31 }, "textPosition" : { "x" : 2159, "y" : 1712 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2222, "y" : 1712 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2222, "y" : 1712 } } }, "connectors" : [ { "edgeId" : 100355, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2160, "y" : 1704 }, "to" : { "x" : 2139, "y" : 1696 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100359, "reactomeId" : 114519, "displayName" : "DAG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2020, "y" : 1723 }, "minX" : 1977, "maxX" : 2078, "minY" : 1694, "maxY" : 1739, "prop" : { "x" : 1999, "y" : 1708, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 2003, "y" : 1713 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2037, "y" : 1713 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2037, "y" : 1713 } } }, "connectors" : [ { "edgeId" : 100355, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2045, "y" : 1712 }, "to" : { "x" : 2078, "y" : 1694 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2049, "y" : 1705 }, "b" : { "x" : 2045, "y" : 1712 }, "c" : { "x" : 2053, "y" : 1712 }, "type" : "ARROW", "centre" : { "x" : 2053, "y" : 1712 } } }, { "edgeId" : 100362, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1996, "y" : 1712 }, "to" : { "x" : 1977, "y" : 1702 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100358, "reactomeId" : 114520, "displayName" : "I(1,4,5)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2202, "y" : 1277 }, "minX" : 2078, "maxX" : 2241, "minY" : 1261, "maxY" : 1694, "prop" : { "x" : 2165, "y" : 1262, "width" : 75, "height" : 31 }, "textPosition" : { "x" : 2168, "y" : 1267 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2235, "y" : 1267 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2235, "y" : 1267 } } }, "connectors" : [ { "edgeId" : 100355, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2197, "y" : 1296 }, "to" : { "x" : 2078, "y" : 1694 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2199, "y" : 1304 }, "b" : { "x" : 2197, "y" : 1296 }, "c" : { "x" : 2191, "y" : 1301 }, "type" : "ARROW", "centre" : { "x" : 2191, "y" : 1301 } } } ] }, { "id" : 100361, "reactomeId" : 10136102, "displayName" : "PLC beta1,2,3:G-alpha(q):GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2311, "y" : 1724 }, "minX" : 2106, "maxX" : 2373, "minY" : 1700, "maxY" : 1755, "prop" : { "x" : 2255, "y" : 1706, "width" : 112, "height" : 37 }, "textPosition" : { "x" : 2255, "y" : 1708 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2367, "y" : 1706 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2367, "y" : 1706 } } }, "connectors" : [ { "edgeId" : 100355, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2252, "y" : 1737 }, "to" : { "x" : 2186, "y" : 1755 } }, { "from" : { "x" : 2186, "y" : 1755 }, "to" : { "x" : 2109, "y" : 1754 } }, { "from" : { "x" : 2109, "y" : 1754 }, "to" : { "x" : 2110, "y" : 1711 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2110, "y" : 1707 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2110, "y" : 1707 } } } ] }, { "id" : 100360, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2048, "y" : 1644 }, "minX" : 2030, "maxX" : 2078, "minY" : 1628, "maxY" : 1694, "prop" : { "x" : 2030, "y" : 1629, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 2034, "y" : 1634 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2061, "y" : 1634 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2061, "y" : 1634 } } }, "connectors" : [ { "edgeId" : 100355, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2057, "y" : 1663 }, "to" : { "x" : 2078, "y" : 1694 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2064, "y" : 1666 }, "b" : { "x" : 2057, "y" : 1663 }, "c" : { "x" : 2058, "y" : 1671 }, "type" : "ARROW", "centre" : { "x" : 2058, "y" : 1671 } } } ], "trivial" : true }, { "id" : 100363, "reactomeId" : 10112196, "displayName" : "PRKCA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1971, "y" : 1648 }, "minX" : 1938, "maxX" : 2001, "minY" : 1631, "maxY" : 1702, "prop" : { "x" : 1947, "y" : 1637, "width" : 48, "height" : 23 }, "textPosition" : { "x" : 1947, "y" : 1638 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1995, "y" : 1637 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1995, "y" : 1637 } } }, "connectors" : [ { "edgeId" : 100362, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1972, "y" : 1663 }, "to" : { "x" : 1977, "y" : 1702 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100362, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1963, "y" : 1663 }, "to" : { "x" : 1944, "y" : 1688 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1942, "y" : 1691 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1942, "y" : 1691 } } } ] }, { "id" : 100364, "reactomeId" : 10136091, "displayName" : "Protein Kinase C, alpha type: DAG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1833, "y" : 1726 }, "minX" : 1654, "maxX" : 1895, "minY" : 1702, "maxY" : 1764, "prop" : { "x" : 1778, "y" : 1708, "width" : 111, "height" : 37 }, "textPosition" : { "x" : 1782, "y" : 1696 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1889, "y" : 1708 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1889, "y" : 1708 } } }, "connectors" : [ { "edgeId" : 100362, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100365, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1786, "y" : 1748 }, "to" : { "x" : 1738, "y" : 1764 } }, { "from" : { "x" : 1738, "y" : 1764 }, "to" : { "x" : 1660, "y" : 1763 } }, { "from" : { "x" : 1660, "y" : 1763 }, "to" : { "x" : 1658, "y" : 1710 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1658, "y" : 1706 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1658, "y" : 1706 } } } ] }, { "id" : 100367, "reactomeId" : 10136083, "displayName" : "Marcks", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1721, "y" : 1726 }, "minX" : 1675, "maxX" : 1756, "minY" : 1694, "maxY" : 1738, "prop" : { "x" : 1693, "y" : 1715, "width" : 57, "height" : 23 }, "textPosition" : { "x" : 1695, "y" : 1716 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1750, "y" : 1715 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1750, "y" : 1715 } } }, "connectors" : [ { "edgeId" : 100365, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1704, "y" : 1712 }, "to" : { "x" : 1675, "y" : 1694 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100366, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1716, "y" : 1655 }, "minX" : 1675, "maxX" : 1737, "minY" : 1639, "maxY" : 1694, "prop" : { "x" : 1696, "y" : 1640, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1700, "y" : 1645 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1731, "y" : 1645 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1731, "y" : 1645 } } }, "connectors" : [ { "edgeId" : 100365, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1699, "y" : 1674 }, "to" : { "x" : 1675, "y" : 1694 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1681, "y" : 1678 }, "b" : { "x" : 1693, "y" : 1690 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1687, "y" : 1684 } } } } ] }, { "id" : 100369, "reactomeId" : 10136089, "displayName" : "phospho-Marcks", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1586, "y" : 1725 }, "minX" : 1540, "maxX" : 1639, "minY" : 1694, "maxY" : 1737, "prop" : { "x" : 1540, "y" : 1714, "width" : 93, "height" : 23 }, "textPosition" : { "x" : 1553, "y" : 1708 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1633, "y" : 1714 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1633, "y" : 1714 } } }, "connectors" : [ { "edgeId" : 100365, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1605, "y" : 1711 }, "to" : { "x" : 1639, "y" : 1694 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1609, "y" : 1704 }, "b" : { "x" : 1605, "y" : 1711 }, "c" : { "x" : 1613, "y" : 1711 }, "type" : "ARROW", "centre" : { "x" : 1613, "y" : 1711 } } } ] }, { "id" : 100368, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1594, "y" : 1655 }, "minX" : 1574, "maxX" : 1639, "minY" : 1639, "maxY" : 1694, "prop" : { "x" : 1574, "y" : 1640, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1578, "y" : 1645 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1610, "y" : 1645 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1610, "y" : 1645 } } }, "connectors" : [ { "edgeId" : 100365, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1611, "y" : 1674 }, "to" : { "x" : 1639, "y" : 1694 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1619, "y" : 1678 }, "b" : { "x" : 1631, "y" : 1690 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1625, "y" : 1684 } } }, "endShape" : { "a" : { "x" : 1619, "y" : 1675 }, "b" : { "x" : 1611, "y" : 1674 }, "c" : { "x" : 1614, "y" : 1681 }, "type" : "ARROW", "centre" : { "x" : 1614, "y" : 1681 } } } ] }, { "id" : 100371, "reactomeId" : 400427, "displayName" : "FFAR1 ligands", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3176, "y" : 1296 }, "minX" : 3095, "maxX" : 3205, "minY" : 1277, "maxY" : 1315, "prop" : { "x" : 3148, "y" : 1277, "width" : 57, "height" : 38 }, "textPosition" : { "x" : 3150, "y" : 1278 }, "connectors" : [ { "edgeId" : 100370, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3142, "y" : 1296 }, "to" : { "x" : 3095, "y" : 1296 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100373, "reactomeId" : 10132466, "displayName" : "FFAR1:FFAR1 ligands", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3095, "y" : 1355 }, "minX" : 3030, "maxX" : 3166, "minY" : 1338, "maxY" : 1509, "prop" : { "x" : 3030, "y" : 1344, "width" : 130, "height" : 23 }, "textPosition" : { "x" : 3049, "y" : 1332 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3160, "y" : 1344 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3160, "y" : 1344 } } }, "connectors" : [ { "edgeId" : 100370, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100374, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3120, "y" : 1370 }, "to" : { "x" : 3163, "y" : 1386 } }, { "from" : { "x" : 3163, "y" : 1386 }, "to" : { "x" : 3161, "y" : 1505 } }, { "from" : { "x" : 3161, "y" : 1505 }, "to" : { "x" : 3109, "y" : 1505 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3105, "y" : 1505 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3105, "y" : 1505 } } } ] }, { "id" : 100372, "reactomeId" : 10132464, "displayName" : "Ffar1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3095, "y" : 1247 }, "minX" : 3073, "maxX" : 3153, "minY" : 1230, "maxY" : 1296, "prop" : { "x" : 3073, "y" : 1236, "width" : 45, "height" : 23 }, "textPosition" : { "x" : 3075, "y" : 1237 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3118, "y" : 1236 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3118, "y" : 1236 } } }, "connectors" : [ { "edgeId" : 100370, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3095, "y" : 1262 }, "to" : { "x" : 3095, "y" : 1296 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100370, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3108, "y" : 1262 }, "to" : { "x" : 3129, "y" : 1277 } }, { "from" : { "x" : 3129, "y" : 1277 }, "to" : { "x" : 3109, "y" : 1288 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3106, "y" : 1289 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3106, "y" : 1289 } } }, { "edgeId" : 100464, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3121, "y" : 1247 }, "to" : { "x" : 3153, "y" : 1247 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100375, "reactomeId" : 10136360, "displayName" : "G-alpha(q)11,14,15,Q:GDP:G-beta:G-gamma", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3088, "y" : 1440 }, "minX" : 3025, "maxX" : 3158, "minY" : 1409, "maxY" : 1492, "prop" : { "x" : 3025, "y" : 1415, "width" : 127, "height" : 51 }, "textPosition" : { "x" : 3026, "y" : 1417 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3152, "y" : 1415 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3152, "y" : 1415 } } }, "connectors" : [ { "edgeId" : 100374, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3090, "y" : 1469 }, "to" : { "x" : 3093, "y" : 1492 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100377, "reactomeId" : 10136116, "displayName" : "G-alpha(q)11,14,15,Q:G-beta:G-gamma", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2801, "y" : 1729 }, "minX" : 2737, "maxX" : 3209, "minY" : 1523, "maxY" : 1789, "prop" : { "x" : 2737, "y" : 1704, "width" : 128, "height" : 51 }, "textPosition" : { "x" : 2737, "y" : 1706 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2865, "y" : 1704 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2865, "y" : 1704 } } }, "connectors" : [ { "edgeId" : 100374, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2848, "y" : 1758 }, "to" : { "x" : 2910, "y" : 1788 } }, { "from" : { "x" : 2910, "y" : 1788 }, "to" : { "x" : 3209, "y" : 1789 } }, { "from" : { "x" : 3209, "y" : 1789 }, "to" : { "x" : 3208, "y" : 1604 } }, { "from" : { "x" : 3208, "y" : 1604 }, "to" : { "x" : 3092, "y" : 1523 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2856, "y" : 1757 }, "b" : { "x" : 2848, "y" : 1758 }, "c" : { "x" : 2852, "y" : 1765 }, "type" : "ARROW", "centre" : { "x" : 2852, "y" : 1765 } } } ] }, { "id" : 100376, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3049, "y" : 1488 }, "minX" : 3029, "maxX" : 3093, "minY" : 1472, "maxY" : 1504, "prop" : { "x" : 3029, "y" : 1473, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 3033, "y" : 1478 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3065, "y" : 1478 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3065, "y" : 1478 } } }, "connectors" : [ { "edgeId" : 100374, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3073, "y" : 1489 }, "to" : { "x" : 3093, "y" : 1492 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100378, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3050, "y" : 1539 }, "minX" : 3029, "maxX" : 3092, "minY" : 1523, "maxY" : 1555, "prop" : { "x" : 3029, "y" : 1524, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 3033, "y" : 1529 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3066, "y" : 1529 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3066, "y" : 1529 } } }, "connectors" : [ { "edgeId" : 100374, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3074, "y" : 1531 }, "to" : { "x" : 3092, "y" : 1523 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3079, "y" : 1525 }, "b" : { "x" : 3074, "y" : 1531 }, "c" : { "x" : 3082, "y" : 1532 }, "type" : "ARROW", "centre" : { "x" : 3082, "y" : 1532 } } } ] }, { "id" : 100381, "reactomeId" : 10134051, "displayName" : "mature GLP1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 92, "y" : 937 }, "minX" : 50, "maxX" : 192, "minY" : 898, "maxY" : 949, "prop" : { "x" : 50, "y" : 926, "width" : 84, "height" : 23 }, "textPosition" : { "x" : 63, "y" : 920 }, "connectors" : [ { "edgeId" : 100379, "type" : "INPUT", "segments" : [ { "from" : { "x" : 125, "y" : 920 }, "to" : { "x" : 192, "y" : 903 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100379, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 91, "y" : 920 }, "to" : { "x" : 90, "y" : 900 } }, { "from" : { "x" : 90, "y" : 900 }, "to" : { "x" : 176, "y" : 902 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 180, "y" : 902 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 180, "y" : 902 } } } ] }, { "id" : 100380, "reactomeId" : 10134074, "displayName" : "GLP1R:Heterotrimeric G(s):GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 194, "y" : 966 }, "minX" : 125, "maxX" : 262, "minY" : 903, "maxY" : 1001, "prop" : { "x" : 133, "y" : 941, "width" : 123, "height" : 51 }, "textPosition" : { "x" : 139, "y" : 943 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 256, "y" : 941 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 256, "y" : 941 } } }, "connectors" : [ { "edgeId" : 100379, "type" : "INPUT", "segments" : [ { "from" : { "x" : 193, "y" : 938 }, "to" : { "x" : 192, "y" : 903 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100461, "type" : "INPUT", "segments" : [ { "from" : { "x" : 143, "y" : 995 }, "to" : { "x" : 125, "y" : 1001 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100382, "reactomeId" : 10134078, "displayName" : "GLP1:GLP1R:Heterotrimeric G(s):GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 192, "y" : 852 }, "minX" : 131, "maxX" : 260, "minY" : 821, "maxY" : 878, "prop" : { "x" : 131, "y" : 827, "width" : 123, "height" : 51 }, "textPosition" : { "x" : 137, "y" : 829 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 254, "y" : 827 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 254, "y" : 827 } } }, "connectors" : [ { "edgeId" : 100379, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100385, "reactomeId" : 10112081, "displayName" : "PKA catalytic subunit", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1062, "y" : 201 }, "minX" : 998, "maxX" : 2925, "minY" : 145, "maxY" : 325, "prop" : { "x" : 998, "y" : 190, "width" : 128, "height" : 23 }, "textPosition" : { "x" : 1016, "y" : 184 }, "connectors" : [ { "edgeId" : 100383, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1062, "y" : 184 }, "to" : { "x" : 1063, "y" : 153 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1063, "y" : 149 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1063, "y" : 149 } } }, { "edgeId" : 100403, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1132, "y" : 205 }, "to" : { "x" : 2843, "y" : 325 } }, { "from" : { "x" : 2843, "y" : 325 }, "to" : { "x" : 2925, "y" : 201 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2925, "y" : 209 }, "b" : { "x" : 2925, "y" : 201 }, "c" : { "x" : 2918, "y" : 205 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2918, "y" : 205 } } } ] }, { "id" : 100384, "reactomeId" : 10134136, "displayName" : "Potassium voltage-gated channels (beta cell, open)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 963, "y" : 137 }, "minX" : 896, "maxX" : 1030, "minY" : 112, "maxY" : 163, "prop" : { "x" : 896, "y" : 112, "width" : 134, "height" : 51 }, "textPosition" : { "x" : 899, "y" : 113 }, "connectors" : [ { "edgeId" : 100383, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100387, "reactomeId" : 10134095, "displayName" : "Ca-channel (closed)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2565, "y" : 1154 }, "minX" : 2503, "maxX" : 2627, "minY" : 1143, "maxY" : 1166, "prop" : { "x" : 2503, "y" : 1143, "width" : 124, "height" : 23 }, "textPosition" : { "x" : 2524, "y" : 1137 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 100386, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100389, "reactomeId" : 10112081, "displayName" : "PKA catalytic subunit", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2683, "y" : 1208 }, "minX" : 2573, "maxX" : 2747, "minY" : 1197, "maxY" : 1220, "prop" : { "x" : 2619, "y" : 1197, "width" : 128, "height" : 23 }, "textPosition" : { "x" : 2637, "y" : 1191 }, "connectors" : [ { "edgeId" : 100386, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2613, "y" : 1208 }, "to" : { "x" : 2581, "y" : 1209 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2577, "y" : 1209 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2577, "y" : 1209 } } } ] }, { "id" : 100388, "reactomeId" : 10134103, "displayName" : "Ca-channel (open)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2565, "y" : 1270 }, "minX" : 2507, "maxX" : 2623, "minY" : 1259, "maxY" : 1282, "prop" : { "x" : 2507, "y" : 1259, "width" : 116, "height" : 23 }, "textPosition" : { "x" : 2524, "y" : 1253 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 100386, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100391, "reactomeId" : 10129288, "displayName" : "RAPGEF3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1503, "y" : 141 }, "minX" : 1472, "maxX" : 1590, "minY" : 124, "maxY" : 175, "prop" : { "x" : 1472, "y" : 130, "width" : 62, "height" : 23 }, "textPosition" : { "x" : 1475, "y" : 124 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1534, "y" : 130 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1534, "y" : 130 } } }, "connectors" : [ { "edgeId" : 100390, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1522, "y" : 156 }, "to" : { "x" : 1562, "y" : 175 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100390, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1537, "y" : 140 }, "to" : { "x" : 1585, "y" : 140 } }, { "from" : { "x" : 1585, "y" : 140 }, "to" : { "x" : 1586, "y" : 160 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1586, "y" : 164 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1586, "y" : 164 } } } ] }, { "id" : 100393, "reactomeId" : 10129290, "displayName" : "RAPGEF3:cAMP complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1665, "y" : 141 }, "minX" : 1615, "maxX" : 2923, "minY" : 117, "maxY" : 290, "prop" : { "x" : 1615, "y" : 123, "width" : 101, "height" : 37 }, "textPosition" : { "x" : 1613, "y" : 125 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1716, "y" : 123 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1716, "y" : 123 } } }, "connectors" : [ { "edgeId" : 100390, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100403, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1701, "y" : 163 }, "to" : { "x" : 1852, "y" : 236 } }, { "from" : { "x" : 1852, "y" : 236 }, "to" : { "x" : 2807, "y" : 290 } }, { "from" : { "x" : 2807, "y" : 290 }, "to" : { "x" : 2923, "y" : 199 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2920, "y" : 206 }, "b" : { "x" : 2923, "y" : 199 }, "c" : { "x" : 2915, "y" : 200 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2915, "y" : 200 } } } ] }, { "id" : 100392, "reactomeId" : 30389, "displayName" : "cAMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 602, "y" : 247 }, "minX" : 578, "maxX" : 1819, "minY" : 174, "maxY" : 275, "prop" : { "x" : 578, "y" : 232, "width" : 48, "height" : 31 }, "textPosition" : { "x" : 581, "y" : 237 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 621, "y" : 237 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 621, "y" : 237 } } }, "connectors" : [ { "edgeId" : 100390, "type" : "INPUT", "segments" : [ { "from" : { "x" : 629, "y" : 246 }, "to" : { "x" : 1543, "y" : 214 } }, { "from" : { "x" : 1543, "y" : 214 }, "to" : { "x" : 1562, "y" : 175 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100394, "type" : "INPUT", "segments" : [ { "from" : { "x" : 629, "y" : 247 }, "to" : { "x" : 1819, "y" : 275 } }, { "from" : { "x" : 1819, "y" : 275 }, "to" : { "x" : 1818, "y" : 174 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1218, "y" : 255 }, "b" : { "x" : 1230, "y" : 267 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1224, "y" : 261 } } } } ] }, { "id" : 100395, "reactomeId" : 10129282, "displayName" : "Rapgef4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1772, "y" : 140 }, "minX" : 1741, "maxX" : 1853, "minY" : 123, "maxY" : 174, "prop" : { "x" : 1741, "y" : 129, "width" : 62, "height" : 23 }, "textPosition" : { "x" : 1742, "y" : 130 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1803, "y" : 129 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1803, "y" : 129 } } }, "connectors" : [ { "edgeId" : 100394, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1787, "y" : 155 }, "to" : { "x" : 1818, "y" : 174 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100394, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1806, "y" : 140 }, "to" : { "x" : 1848, "y" : 140 } }, { "from" : { "x" : 1848, "y" : 140 }, "to" : { "x" : 1849, "y" : 158 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1849, "y" : 162 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1849, "y" : 162 } } } ] }, { "id" : 100396, "reactomeId" : 10129284, "displayName" : "RAPGEF4:cAMP Complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1921, "y" : 139 }, "minX" : 1871, "maxX" : 2922, "minY" : 115, "maxY" : 266, "prop" : { "x" : 1871, "y" : 121, "width" : 101, "height" : 37 }, "textPosition" : { "x" : 1869, "y" : 123 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1972, "y" : 121 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1972, "y" : 121 } } }, "connectors" : [ { "edgeId" : 100394, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100403, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1954, "y" : 161 }, "to" : { "x" : 2085, "y" : 229 } }, { "from" : { "x" : 2085, "y" : 229 }, "to" : { "x" : 2780, "y" : 266 } }, { "from" : { "x" : 2780, "y" : 266 }, "to" : { "x" : 2922, "y" : 197 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2918, "y" : 204 }, "b" : { "x" : 2922, "y" : 197 }, "c" : { "x" : 2914, "y" : 196 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2914, "y" : 196 } } } ] }, { "id" : 100399, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2187, "y" : 179 }, "minX" : 2167, "maxX" : 2219, "minY" : 137, "maxY" : 195, "prop" : { "x" : 2167, "y" : 164, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 2171, "y" : 169 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2203, "y" : 169 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2203, "y" : 169 } } }, "connectors" : [ { "edgeId" : 100397, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2198, "y" : 161 }, "to" : { "x" : 2219, "y" : 137 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100398, "reactomeId" : 10134140, "displayName" : "RAP1A:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2151, "y" : 138 }, "minX" : 2113, "maxX" : 2219, "minY" : 121, "maxY" : 150, "prop" : { "x" : 2113, "y" : 127, "width" : 77, "height" : 23 }, "textPosition" : { "x" : 2125, "y" : 115 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2190, "y" : 127 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2190, "y" : 127 } } }, "connectors" : [ { "edgeId" : 100397, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2193, "y" : 137 }, "to" : { "x" : 2219, "y" : 137 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100401, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2310, "y" : 179 }, "minX" : 2273, "maxX" : 2332, "minY" : 137, "maxY" : 195, "prop" : { "x" : 2289, "y" : 164, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 2293, "y" : 169 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2326, "y" : 169 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2326, "y" : 169 } } }, "connectors" : [ { "edgeId" : 100397, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2296, "y" : 161 }, "to" : { "x" : 2273, "y" : 137 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2288, "y" : 159 }, "b" : { "x" : 2296, "y" : 161 }, "c" : { "x" : 2294, "y" : 153 }, "type" : "ARROW", "centre" : { "x" : 2294, "y" : 153 } } } ] }, { "id" : 100400, "reactomeId" : 10134142, "displayName" : "RAP1A:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2344, "y" : 138 }, "minX" : 2273, "maxX" : 2388, "minY" : 121, "maxY" : 150, "prop" : { "x" : 2306, "y" : 127, "width" : 76, "height" : 23 }, "textPosition" : { "x" : 2306, "y" : 129 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2382, "y" : 127 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2382, "y" : 127 } } }, "connectors" : [ { "edgeId" : 100397, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2303, "y" : 137 }, "to" : { "x" : 2273, "y" : 137 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2296, "y" : 141 }, "b" : { "x" : 2303, "y" : 137 }, "c" : { "x" : 2296, "y" : 133 }, "type" : "ARROW", "centre" : { "x" : 2296, "y" : 133 } } } ] }, { "id" : 100402, "reactomeId" : 10134144, "displayName" : "Epac1,2:cAMP complex", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2041, "y" : 139 }, "minX" : 1993, "maxX" : 2240, "minY" : 95, "maxY" : 158, "prop" : { "x" : 1993, "y" : 121, "width" : 96, "height" : 37 }, "textPosition" : { "x" : 1991, "y" : 122 }, "connectors" : [ { "edgeId" : 100397, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2087, "y" : 115 }, "to" : { "x" : 2152, "y" : 95 } }, { "from" : { "x" : 2152, "y" : 95 }, "to" : { "x" : 2232, "y" : 131 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2236, "y" : 132 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2236, "y" : 132 } } } ] }, { "id" : 100405, "reactomeId" : 10129273, "displayName" : "KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2700, "y" : 139 }, "minX" : 2641, "maxX" : 2922, "minY" : 62, "maxY" : 194, "prop" : { "x" : 2641, "y" : 114, "width" : 119, "height" : 51 }, "textPosition" : { "x" : 2640, "y" : 116 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2760, "y" : 114 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2760, "y" : 114 } } }, "connectors" : [ { "edgeId" : 100455, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2708, "y" : 111 }, "to" : { "x" : 2725, "y" : 68 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100458, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2763, "y" : 118 }, "to" : { "x" : 2920, "y" : 62 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100403, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2755, "y" : 168 }, "to" : { "x" : 2817, "y" : 193 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100403, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2763, "y" : 152 }, "to" : { "x" : 2914, "y" : 189 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2918, "y" : 190 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2918, "y" : 190 } } } ] }, { "id" : 100404, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2767, "y" : 218 }, "minX" : 2747, "maxX" : 2817, "minY" : 193, "maxY" : 234, "prop" : { "x" : 2747, "y" : 203, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 2751, "y" : 208 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2782, "y" : 208 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2782, "y" : 208 } } }, "connectors" : [ { "edgeId" : 100403, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2790, "y" : 208 }, "to" : { "x" : 2817, "y" : 193 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 2797, "y" : 194 }, "b" : { "x" : 2809, "y" : 206 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2803, "y" : 200 } } } } ] }, { "id" : 100407, "reactomeId" : 6790050, "displayName" : "Mg2+:ADP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3037, "y" : 234 }, "minX" : 2969, "maxX" : 3079, "minY" : 193, "maxY" : 246, "prop" : { "x" : 3001, "y" : 223, "width" : 72, "height" : 23 }, "textPosition" : { "x" : 3013, "y" : 211 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3073, "y" : 223 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3073, "y" : 223 } } }, "connectors" : [ { "edgeId" : 100403, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3017, "y" : 220 }, "to" : { "x" : 2969, "y" : 193 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 2987, "y" : 200 }, "b" : { "x" : 2999, "y" : 212 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2993, "y" : 206 } } }, "endShape" : { "a" : { "x" : 3009, "y" : 220 }, "b" : { "x" : 3017, "y" : 220 }, "c" : { "x" : 3013, "y" : 213 }, "type" : "ARROW", "centre" : { "x" : 3013, "y" : 213 } } } ] }, { "id" : 100406, "reactomeId" : 10129277, "displayName" : "KCNJ11:ATP tetramer:ABCC8 tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3112, "y" : 170 }, "minX" : 2969, "maxX" : 3171, "minY" : 139, "maxY" : 196, "prop" : { "x" : 3059, "y" : 145, "width" : 106, "height" : 51 }, "textPosition" : { "x" : 3071, "y" : 133 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3165, "y" : 145 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3165, "y" : 145 } } }, "connectors" : [ { "edgeId" : 100403, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3056, "y" : 178 }, "to" : { "x" : 2969, "y" : 193 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3050, "y" : 183 }, "b" : { "x" : 3056, "y" : 178 }, "c" : { "x" : 3048, "y" : 175 }, "type" : "ARROW", "centre" : { "x" : 3048, "y" : 175 } } } ] }, { "id" : 100409, "reactomeId" : 158417, "displayName" : "Zn2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3185, "y" : 326 }, "minX" : 2933, "maxX" : 3211, "minY" : 197, "maxY" : 342, "prop" : { "x" : 3161, "y" : 311, "width" : 49, "height" : 31 }, "textPosition" : { "x" : 3164, "y" : 316 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3205, "y" : 316 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3205, "y" : 316 } } }, "connectors" : [ { "edgeId" : 100403, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 3158, "y" : 320 }, "to" : { "x" : 3020, "y" : 287 } }, { "from" : { "x" : 3020, "y" : 287 }, "to" : { "x" : 2936, "y" : 200 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2933, "y" : 203 }, "b" : { "x" : 2939, "y" : 197 }, "c" : { "x" : 2936, "y" : 200 }, "type" : "STOP", "centre" : { "x" : 2936, "y" : 200 } } } ] }, { "id" : 100408, "reactomeId" : 70113, "displayName" : "Glc", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2973, "y" : 414 }, "minX" : 2929, "maxX" : 2992, "minY" : 202, "maxY" : 430, "prop" : { "x" : 2956, "y" : 399, "width" : 35, "height" : 31 }, "textPosition" : { "x" : 2960, "y" : 404 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2986, "y" : 404 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2986, "y" : 404 } } }, "connectors" : [ { "edgeId" : 100403, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 2969, "y" : 396 }, "to" : { "x" : 2932, "y" : 202 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2937, "y" : 208 }, "b" : { "x" : 2932, "y" : 202 }, "c" : { "x" : 2929, "y" : 210 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2929, "y" : 210 } } }, { "edgeId" : 100414, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100411, "reactomeId" : 74112, "displayName" : "Ca2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3179, "y" : 1065 }, "minX" : 3154, "maxX" : 3205, "minY" : 1049, "maxY" : 1081, "prop" : { "x" : 3154, "y" : 1050, "width" : 50, "height" : 31 }, "textPosition" : { "x" : 3158, "y" : 1055 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3199, "y" : 1055 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3199, "y" : 1055 } } }, "connectors" : [ { "edgeId" : 100410, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100413, "reactomeId" : 10129252, "displayName" : "Voltage-gated Calcium Channels (pancreatic beta cell)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3095, "y" : 994 }, "minX" : 3030, "maxX" : 3160, "minY" : 969, "maxY" : 1057, "prop" : { "x" : 3030, "y" : 969, "width" : 130, "height" : 51 }, "textPosition" : { "x" : 3034, "y" : 963 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 100410, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3094, "y" : 1026 }, "to" : { "x" : 3094, "y" : 1049 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3094, "y" : 1053 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3094, "y" : 1053 } } } ] }, { "id" : 100412, "reactomeId" : 74016, "displayName" : "Ca2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2643, "y" : 1066 }, "minX" : 2618, "maxX" : 2669, "minY" : 1050, "maxY" : 1082, "prop" : { "x" : 2618, "y" : 1051, "width" : 50, "height" : 31 }, "textPosition" : { "x" : 2622, "y" : 1056 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2663, "y" : 1056 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2663, "y" : 1056 } } }, "connectors" : [ { "edgeId" : 100410, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100415, "reactomeId" : 70115, "displayName" : "Glc", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3152, "y" : 413 }, "minX" : 3135, "maxX" : 3171, "minY" : 397, "maxY" : 429, "prop" : { "x" : 3135, "y" : 398, "width" : 35, "height" : 31 }, "textPosition" : { "x" : 3139, "y" : 403 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3165, "y" : 403 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3165, "y" : 403 } } }, "connectors" : [ { "edgeId" : 100414, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100416, "reactomeId" : 10143070, "displayName" : "GLUT1,2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3095, "y" : 471 }, "minX" : 3065, "maxX" : 3125, "minY" : 421, "maxY" : 483, "prop" : { "x" : 3065, "y" : 460, "width" : 60, "height" : 23 }, "textPosition" : { "x" : 3065, "y" : 461 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 100414, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3095, "y" : 454 }, "to" : { "x" : 3095, "y" : 429 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3095, "y" : 425 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3095, "y" : 425 } } } ] }, { "id" : 100419, "reactomeId" : 10116228, "displayName" : "Gcgr", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 190, "y" : 666 }, "minX" : 169, "maxX" : 228, "minY" : 602, "maxY" : 678, "prop" : { "x" : 169, "y" : 655, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 172, "y" : 656 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 212, "y" : 655 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 212, "y" : 655 } } }, "connectors" : [ { "edgeId" : 100417, "type" : "INPUT", "segments" : [ { "from" : { "x" : 190, "y" : 652 }, "to" : { "x" : 190, "y" : 630 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100417, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 215, "y" : 664 }, "to" : { "x" : 228, "y" : 664 } }, { "from" : { "x" : 228, "y" : 664 }, "to" : { "x" : 228, "y" : 606 } }, { "from" : { "x" : 228, "y" : 606 }, "to" : { "x" : 206, "y" : 606 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 202, "y" : 606 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 202, "y" : 606 } } } ] }, { "id" : 100418, "reactomeId" : 10116223, "displayName" : "Gcg", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 115, "y" : 665 }, "minX" : 74, "maxX" : 190, "minY" : 630, "maxY" : 677, "prop" : { "x" : 74, "y" : 654, "width" : 82, "height" : 23 }, "textPosition" : { "x" : 99, "y" : 655 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 156, "y" : 654 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 156, "y" : 654 } } }, "connectors" : [ { "edgeId" : 100417, "type" : "INPUT", "segments" : [ { "from" : { "x" : 139, "y" : 651 }, "to" : { "x" : 190, "y" : 630 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100420, "reactomeId" : 10116230, "displayName" : "GCGR:GCG(53-81)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 191, "y" : 568 }, "minX" : 131, "maxX" : 257, "minY" : 551, "maxY" : 580, "prop" : { "x" : 131, "y" : 557, "width" : 120, "height" : 23 }, "textPosition" : { "x" : 132, "y" : 559 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 251, "y" : 557 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 251, "y" : 557 } } }, "connectors" : [ { "edgeId" : 100417, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100423, "reactomeId" : 10112081, "displayName" : "PKA catalytic subunit", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1078, "y" : 527 }, "minX" : 1008, "maxX" : 1142, "minY" : 471, "maxY" : 539, "prop" : { "x" : 1014, "y" : 516, "width" : 128, "height" : 23 }, "textPosition" : { "x" : 1032, "y" : 510 }, "connectors" : [ { "edgeId" : 100421, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1063, "y" : 510 }, "to" : { "x" : 1008, "y" : 471 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1029, "y" : 484 }, "b" : { "x" : 1041, "y" : 496 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1035, "y" : 490 } } }, "endShape" : { "a" : { "x" : 1055, "y" : 509 }, "b" : { "x" : 1063, "y" : 510 }, "c" : { "x" : 1060, "y" : 503 }, "type" : "ARROW", "centre" : { "x" : 1060, "y" : 503 } } } ] }, { "id" : 100422, "reactomeId" : 10112085, "displayName" : "PKA tetramer:4xcAMP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 903, "y" : 471 }, "minX" : 858, "maxX" : 984, "minY" : 447, "maxY" : 498, "prop" : { "x" : 858, "y" : 453, "width" : 90, "height" : 37 }, "textPosition" : { "x" : 869, "y" : 441 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 948, "y" : 453 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 948, "y" : 453 } } }, "connectors" : [ { "edgeId" : 100421, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100421, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 951, "y" : 486 }, "to" : { "x" : 980, "y" : 498 } }, { "from" : { "x" : 980, "y" : 498 }, "to" : { "x" : 980, "y" : 488 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 980, "y" : 484 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 980, "y" : 484 } } } ] }, { "id" : 100424, "reactomeId" : 10112087, "displayName" : "cAMP:PKA regulatory subunit", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1074, "y" : 421 }, "minX" : 1008, "maxX" : 1147, "minY" : 397, "maxY" : 471, "prop" : { "x" : 1008, "y" : 403, "width" : 133, "height" : 37 }, "textPosition" : { "x" : 1013, "y" : 405 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1141, "y" : 403 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1141, "y" : 403 } } }, "connectors" : [ { "edgeId" : 100421, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1049, "y" : 443 }, "to" : { "x" : 1008, "y" : 471 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1046, "y" : 450 }, "b" : { "x" : 1049, "y" : 443 }, "c" : { "x" : 1041, "y" : 444 }, "type" : "ARROW", "centre" : { "x" : 1041, "y" : 444 } } } ] }, { "id" : 100427, "reactomeId" : 10116254, "displayName" : "phospho-Mlxipl", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1172, "y" : 578 }, "minX" : 1121, "maxX" : 1230, "minY" : 561, "maxY" : 590, "prop" : { "x" : 1121, "y" : 567, "width" : 103, "height" : 23 }, "textPosition" : { "x" : 1122, "y" : 568 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1224, "y" : 567 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1224, "y" : 567 } } }, "connectors" : [ { "edgeId" : 100425, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100428, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100426, "reactomeId" : 10116256, "displayName" : "phospho-Mlxipl", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1435, "y" : 535 }, "minX" : 1384, "maxX" : 1493, "minY" : 518, "maxY" : 547, "prop" : { "x" : 1384, "y" : 524, "width" : 103, "height" : 23 }, "textPosition" : { "x" : 1385, "y" : 525 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1487, "y" : 524 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1487, "y" : 524 } } }, "connectors" : [ { "edgeId" : 100425, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100428, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100431, "reactomeId" : 29878, "displayName" : "E4P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 455, "y" : 1040 }, "minX" : 395, "maxX" : 527, "minY" : 860, "maxY" : 1056, "prop" : { "x" : 436, "y" : 1025, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 439, "y" : 1030 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 470, "y" : 1030 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 470, "y" : 1030 } } }, "connectors" : [ { "edgeId" : 100429, "type" : "INPUT", "segments" : [ { "from" : { "x" : 478, "y" : 1033 }, "to" : { "x" : 527, "y" : 1016 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100435, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 438, "y" : 1022 }, "to" : { "x" : 395, "y" : 982 } }, { "from" : { "x" : 395, "y" : 982 }, "to" : { "x" : 485, "y" : 860 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 430, "y" : 1020 }, "b" : { "x" : 438, "y" : 1022 }, "c" : { "x" : 436, "y" : 1014 }, "type" : "ARROW", "centre" : { "x" : 436, "y" : 1014 } } } ] }, { "id" : 100430, "reactomeId" : 29512, "displayName" : "Fru(6)P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 456, "y" : 984 }, "minX" : 427, "maxX" : 527, "minY" : 936, "maxY" : 1016, "prop" : { "x" : 427, "y" : 969, "width" : 58, "height" : 31 }, "textPosition" : { "x" : 429, "y" : 974 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 480, "y" : 974 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 480, "y" : 974 } } }, "connectors" : [ { "edgeId" : 100429, "type" : "INPUT", "segments" : [ { "from" : { "x" : 488, "y" : 997 }, "to" : { "x" : 527, "y" : 1016 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100435, "type" : "INPUT", "segments" : [ { "from" : { "x" : 465, "y" : 966 }, "to" : { "x" : 484, "y" : 936 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100433, "reactomeId" : 29578, "displayName" : "GA3P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 649, "y" : 986 }, "minX" : 484, "maxX" : 688, "minY" : 933, "maxY" : 1016, "prop" : { "x" : 625, "y" : 971, "width" : 49, "height" : 31 }, "textPosition" : { "x" : 629, "y" : 976 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 669, "y" : 976 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 669, "y" : 976 } } }, "connectors" : [ { "edgeId" : 100429, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 622, "y" : 1000 }, "to" : { "x" : 599, "y" : 1016 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 619, "y" : 1007 }, "b" : { "x" : 622, "y" : 1000 }, "c" : { "x" : 614, "y" : 1001 }, "type" : "ARROW", "centre" : { "x" : 614, "y" : 1001 } } }, { "edgeId" : 100435, "type" : "INPUT", "segments" : [ { "from" : { "x" : 622, "y" : 978 }, "to" : { "x" : 484, "y" : 936 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100438, "type" : "INPUT", "segments" : [ { "from" : { "x" : 660, "y" : 968 }, "to" : { "x" : 688, "y" : 933 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100432, "reactomeId" : 29882, "displayName" : "SH7P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 646, "y" : 1044 }, "minX" : 599, "maxX" : 714, "minY" : 933, "maxY" : 1060, "prop" : { "x" : 623, "y" : 1029, "width" : 47, "height" : 31 }, "textPosition" : { "x" : 626, "y" : 1034 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 665, "y" : 1034 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 665, "y" : 1034 } } }, "connectors" : [ { "edgeId" : 100429, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 620, "y" : 1030 }, "to" : { "x" : 599, "y" : 1016 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 612, "y" : 1029 }, "b" : { "x" : 620, "y" : 1030 }, "c" : { "x" : 616, "y" : 1023 }, "type" : "ARROW", "centre" : { "x" : 616, "y" : 1023 } } }, { "edgeId" : 100438, "type" : "INPUT", "segments" : [ { "from" : { "x" : 663, "y" : 1026 }, "to" : { "x" : 714, "y" : 983 } }, { "from" : { "x" : 714, "y" : 983 }, "to" : { "x" : 688, "y" : 933 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100434, "reactomeId" : 10105449, "displayName" : "TALDO1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 566, "y" : 1087 }, "minX" : 519, "maxX" : 620, "minY" : 1024, "maxY" : 1099, "prop" : { "x" : 519, "y" : 1076, "width" : 95, "height" : 23 }, "textPosition" : { "x" : 519, "y" : 1078 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 614, "y" : 1076 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 614, "y" : 1076 } } }, "connectors" : [ { "edgeId" : 100429, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 566, "y" : 1073 }, "to" : { "x" : 566, "y" : 1032 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 566, "y" : 1028 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 566, "y" : 1028 } } } ] }, { "id" : 100437, "reactomeId" : 10105440, "displayName" : "TKT dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 560, "y" : 899 }, "minX" : 492, "maxX" : 680, "minY" : 882, "maxY" : 911, "prop" : { "x" : 525, "y" : 888, "width" : 71, "height" : 23 }, "textPosition" : { "x" : 526, "y" : 890 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 596, "y" : 888 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 596, "y" : 888 } } }, "connectors" : [ { "edgeId" : 100435, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 522, "y" : 899 }, "to" : { "x" : 500, "y" : 900 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 496, "y" : 900 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 496, "y" : 900 } } }, { "edgeId" : 100438, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 599, "y" : 900 }, "to" : { "x" : 672, "y" : 902 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 676, "y" : 903 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 676, "y" : 903 } } } ] }, { "id" : 100436, "reactomeId" : 29790, "displayName" : "XY5P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 693, "y" : 778 }, "minX" : 485, "maxX" : 718, "minY" : 762, "maxY" : 860, "prop" : { "x" : 670, "y" : 763, "width" : 47, "height" : 31 }, "textPosition" : { "x" : 674, "y" : 768 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 712, "y" : 768 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 712, "y" : 768 } } }, "connectors" : [ { "edgeId" : 100435, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 667, "y" : 787 }, "to" : { "x" : 485, "y" : 860 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 662, "y" : 793 }, "b" : { "x" : 667, "y" : 787 }, "c" : { "x" : 659, "y" : 786 }, "type" : "ARROW", "centre" : { "x" : 659, "y" : 786 } } }, { "edgeId" : 100438, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 692, "y" : 797 }, "to" : { "x" : 689, "y" : 860 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 696, "y" : 804 }, "b" : { "x" : 692, "y" : 797 }, "c" : { "x" : 688, "y" : 804 }, "type" : "ARROW", "centre" : { "x" : 688, "y" : 804 } } } ] }, { "id" : 100439, "reactomeId" : 73578, "displayName" : "R5P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 633, "y" : 842 }, "minX" : 613, "maxX" : 689, "minY" : 826, "maxY" : 860, "prop" : { "x" : 613, "y" : 827, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 617, "y" : 832 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 648, "y" : 832 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 648, "y" : 832 } } }, "connectors" : [ { "edgeId" : 100438, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 656, "y" : 848 }, "to" : { "x" : 689, "y" : 860 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 664, "y" : 847 }, "b" : { "x" : 656, "y" : 848 }, "c" : { "x" : 661, "y" : 854 }, "type" : "ARROW", "centre" : { "x" : 661, "y" : 854 } } } ] }, { "id" : 100441, "reactomeId" : 164121, "displayName" : "AMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1964, "y" : 465 }, "minX" : 1943, "maxX" : 1986, "minY" : 449, "maxY" : 502, "prop" : { "x" : 1943, "y" : 450, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 1947, "y" : 455 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1980, "y" : 455 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1980, "y" : 455 } } }, "connectors" : [ { "edgeId" : 100440, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1957, "y" : 484 }, "to" : { "x" : 1948, "y" : 502 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100443, "reactomeId" : 10116248, "displayName" : "AMPK heterotrimer:AMP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1847, "y" : 502 }, "minX" : 1786, "maxX" : 1914, "minY" : 478, "maxY" : 521, "prop" : { "x" : 1786, "y" : 484, "width" : 122, "height" : 37 }, "textPosition" : { "x" : 1788, "y" : 486 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1908, "y" : 484 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1908, "y" : 484 } } }, "connectors" : [ { "edgeId" : 100440, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100442, "reactomeId" : 10116244, "displayName" : "AMPK heterotrimer (inactive)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2015, "y" : 524 }, "minX" : 1948, "maxX" : 2082, "minY" : 500, "maxY" : 543, "prop" : { "x" : 1954, "y" : 506, "width" : 122, "height" : 37 }, "textPosition" : { "x" : 1969, "y" : 494 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2076, "y" : 506 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2076, "y" : 506 } } }, "connectors" : [ { "edgeId" : 100440, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1958, "y" : 503 }, "to" : { "x" : 1948, "y" : 502 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100445, "reactomeId" : 8954142, "displayName" : "LCFA(-)", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3194, "y" : 1161 }, "minX" : 3164, "maxX" : 3225, "minY" : 1145, "maxY" : 1177, "prop" : { "x" : 3164, "y" : 1146, "width" : 60, "height" : 31 }, "textPosition" : { "x" : 3168, "y" : 1151 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3219, "y" : 1151 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3219, "y" : 1151 } } }, "connectors" : [ { "edgeId" : 100444, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100447, "reactomeId" : 10139695, "displayName" : "Cd36", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3097, "y" : 1116 }, "minX" : 3047, "maxX" : 3153, "minY" : 1099, "maxY" : 1152, "prop" : { "x" : 3047, "y" : 1105, "width" : 100, "height" : 23 }, "textPosition" : { "x" : 3077, "y" : 1106 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3147, "y" : 1105 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3147, "y" : 1105 } } }, "connectors" : [ { "edgeId" : 100444, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3095, "y" : 1131 }, "to" : { "x" : 3094, "y" : 1144 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3094, "y" : 1148 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3094, "y" : 1148 } } } ] }, { "id" : 100446, "reactomeId" : 8876730, "displayName" : "LCFA(-)", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2993, "y" : 1161 }, "minX" : 2826, "maxX" : 3024, "minY" : 1145, "maxY" : 1400, "prop" : { "x" : 2963, "y" : 1146, "width" : 60, "height" : 31 }, "textPosition" : { "x" : 2967, "y" : 1151 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3018, "y" : 1151 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3018, "y" : 1151 } } }, "connectors" : [ { "edgeId" : 100444, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100448, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2982, "y" : 1180 }, "to" : { "x" : 2826, "y" : 1400 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100449, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2910, "y" : 1354 }, "minX" : 2826, "maxX" : 2931, "minY" : 1338, "maxY" : 1400, "prop" : { "x" : 2890, "y" : 1339, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 2894, "y" : 1344 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2925, "y" : 1344 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2925, "y" : 1344 } } }, "connectors" : [ { "edgeId" : 100448, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2887, "y" : 1364 }, "to" : { "x" : 2826, "y" : 1400 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100451, "reactomeId" : 164991, "displayName" : "LCFA-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2631, "y" : 1399 }, "minX" : 2594, "maxX" : 2727, "minY" : 1383, "maxY" : 1415, "prop" : { "x" : 2594, "y" : 1384, "width" : 75, "height" : 31 }, "textPosition" : { "x" : 2599, "y" : 1389 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2664, "y" : 1389 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2664, "y" : 1389 } } }, "connectors" : [ { "edgeId" : 100448, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2672, "y" : 1399 }, "to" : { "x" : 2727, "y" : 1400 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2679, "y" : 1395 }, "b" : { "x" : 2672, "y" : 1399 }, "c" : { "x" : 2679, "y" : 1403 }, "type" : "ARROW", "centre" : { "x" : 2679, "y" : 1403 } } } ] }, { "id" : 100450, "reactomeId" : 76194, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2918, "y" : 1397 }, "minX" : 2826, "maxX" : 2950, "minY" : 1381, "maxY" : 1413, "prop" : { "x" : 2887, "y" : 1382, "width" : 62, "height" : 31 }, "textPosition" : { "x" : 2891, "y" : 1387 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2944, "y" : 1387 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2944, "y" : 1387 } } }, "connectors" : [ { "edgeId" : 100448, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2884, "y" : 1398 }, "to" : { "x" : 2826, "y" : 1400 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100453, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2727, "y" : 1336 }, "minX" : 2710, "maxX" : 2745, "minY" : 1320, "maxY" : 1400, "prop" : { "x" : 2710, "y" : 1321, "width" : 34, "height" : 31 }, "textPosition" : { "x" : 2713, "y" : 1326 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2739, "y" : 1326 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2739, "y" : 1326 } } }, "connectors" : [ { "edgeId" : 100448, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2727, "y" : 1355 }, "to" : { "x" : 2727, "y" : 1400 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2731, "y" : 1362 }, "b" : { "x" : 2727, "y" : 1355 }, "c" : { "x" : 2723, "y" : 1362 }, "type" : "ARROW", "centre" : { "x" : 2723, "y" : 1362 } } } ] }, { "id" : 100452, "reactomeId" : 76577, "displayName" : "AMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2665, "y" : 1344 }, "minX" : 2644, "maxX" : 2727, "minY" : 1328, "maxY" : 1400, "prop" : { "x" : 2644, "y" : 1329, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 2648, "y" : 1334 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2681, "y" : 1334 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2681, "y" : 1334 } } }, "connectors" : [ { "edgeId" : 100448, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2682, "y" : 1363 }, "to" : { "x" : 2727, "y" : 1400 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2690, "y" : 1364 }, "b" : { "x" : 2682, "y" : 1363 }, "c" : { "x" : 2685, "y" : 1370 }, "type" : "ARROW", "centre" : { "x" : 2685, "y" : 1370 } } } ] }, { "id" : 100454, "reactomeId" : 10139709, "displayName" : "ACSL3,4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2792, "y" : 1452 }, "minX" : 2764, "maxX" : 2821, "minY" : 1408, "maxY" : 1464, "prop" : { "x" : 2764, "y" : 1441, "width" : 57, "height" : 23 }, "textPosition" : { "x" : 2767, "y" : 1435 }, "connectors" : [ { "edgeId" : 100448, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2791, "y" : 1435 }, "to" : { "x" : 2790, "y" : 1416 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2790, "y" : 1412 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2790, "y" : 1412 } } } ] }, { "id" : 100457, "reactomeId" : 10212278, "displayName" : "ABCC8:Meglitinides", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 2850, "y" : 134 }, "minX" : 2790, "maxX" : 2916, "minY" : 117, "maxY" : 146, "prop" : { "x" : 2790, "y" : 123, "width" : 120, "height" : 23 }, "textPosition" : { "x" : 2809, "y" : 111 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2910, "y" : 123 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2910, "y" : 123 } } }, "connectors" : [ { "edgeId" : 100455, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100456, "reactomeId" : 9650988, "displayName" : "Meglitinides", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 2701, "y" : 11 }, "minX" : 2663, "maxX" : 2740, "minY" : 0, "maxY" : 68, "prop" : { "x" : 2663, "y" : 0, "width" : 77, "height" : 23 }, "textPosition" : { "x" : 2664, "y" : -6 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 100455, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2705, "y" : 29 }, "to" : { "x" : 2725, "y" : 68 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100459, "reactomeId" : 9652588, "displayName" : "SU drugs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 2920, "y" : 11 }, "minX" : 2890, "maxX" : 2950, "minY" : 0, "maxY" : 62, "prop" : { "x" : 2890, "y" : 0, "width" : 60, "height" : 23 }, "textPosition" : { "x" : 2898, "y" : -6 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 100458, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2920, "y" : 29 }, "to" : { "x" : 2920, "y" : 62 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100460, "reactomeId" : 10212284, "displayName" : "ABCC8:SU drugs", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 2986, "y" : 135 }, "minX" : 2935, "maxX" : 3044, "minY" : 118, "maxY" : 147, "prop" : { "x" : 2935, "y" : 124, "width" : 103, "height" : 23 }, "textPosition" : { "x" : 2950, "y" : 112 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3038, "y" : 124 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3038, "y" : 124 } } }, "connectors" : [ { "edgeId" : 100458, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100463, "reactomeId" : 10214610, "displayName" : "GLP1R:GLP1R agonists", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 202, "y" : 1025 }, "minX" : 156, "maxX" : 255, "minY" : 1001, "maxY" : 1044, "prop" : { "x" : 156, "y" : 1007, "width" : 93, "height" : 37 }, "textPosition" : { "x" : 156, "y" : 1009 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 249, "y" : 1007 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 249, "y" : 1007 } } }, "connectors" : [ { "edgeId" : 100461, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100462, "reactomeId" : 9728630, "displayName" : "GLP1R agonists", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 49, "y" : 992 }, "minX" : 0, "maxX" : 125, "minY" : 981, "maxY" : 1004, "prop" : { "x" : 0, "y" : 981, "width" : 98, "height" : 23 }, "textPosition" : { "x" : 18, "y" : 975 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 100461, "type" : "INPUT", "segments" : [ { "from" : { "x" : 104, "y" : 997 }, "to" : { "x" : 125, "y" : 1001 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100465, "reactomeId" : 9732524, "displayName" : "rosiglitazone", "schemaClass" : "ChemicalDrug", "renderableClass" : "ChemicalDrug", "position" : { "x" : 3200, "y" : 1220 }, "minX" : 3153, "maxX" : 3245, "minY" : 1205, "maxY" : 1247, "prop" : { "x" : 3155, "y" : 1205, "width" : 90, "height" : 31 }, "textPosition" : { "x" : 3156, "y" : 1210 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 100464, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3173, "y" : 1239 }, "to" : { "x" : 3153, "y" : 1247 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100466, "reactomeId" : 10214698, "displayName" : "FFAR1:rosiglitazone", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 3098, "y" : 1196 }, "minX" : 3037, "maxX" : 3165, "minY" : 1179, "maxY" : 1208, "prop" : { "x" : 3037, "y" : 1185, "width" : 122, "height" : 23 }, "textPosition" : { "x" : 3054, "y" : 1173 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3159, "y" : 1185 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3159, "y" : 1185 } } }, "connectors" : [ { "edgeId" : 100464, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100469, "reactomeId" : 10197693, "displayName" : "ADIPOQ trimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1302, "y" : 1800 }, "minX" : 1256, "maxX" : 1380, "minY" : 1757, "maxY" : 1812, "prop" : { "x" : 1256, "y" : 1789, "width" : 93, "height" : 23 }, "textPosition" : { "x" : 1273, "y" : 1777 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1349, "y" : 1789 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1349, "y" : 1789 } } }, "connectors" : [ { "edgeId" : 100467, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1308, "y" : 1786 }, "to" : { "x" : 1327, "y" : 1757 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100467, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1352, "y" : 1796 }, "to" : { "x" : 1374, "y" : 1795 } }, { "from" : { "x" : 1374, "y" : 1795 }, "to" : { "x" : 1376, "y" : 1773 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1376, "y" : 1769 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1376, "y" : 1769 } } } ] }, { "id" : 100468, "reactomeId" : 10197709, "displayName" : "ADIPOR dimers", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1306, "y" : 1722 }, "minX" : 1258, "maxX" : 1355, "minY" : 1711, "maxY" : 1757, "prop" : { "x" : 1258, "y" : 1711, "width" : 97, "height" : 23 }, "textPosition" : { "x" : 1278, "y" : 1705 }, "connectors" : [ { "edgeId" : 100467, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1312, "y" : 1740 }, "to" : { "x" : 1327, "y" : 1757 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100470, "reactomeId" : 10197711, "displayName" : "ADIPOQ trimer:ADIPOR dimers", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1451, "y" : 1724 }, "minX" : 1403, "maxX" : 1506, "minY" : 1700, "maxY" : 1743, "prop" : { "x" : 1403, "y" : 1706, "width" : 97, "height" : 37 }, "textPosition" : { "x" : 1403, "y" : 1694 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1500, "y" : 1706 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1500, "y" : 1706 } } }, "connectors" : [ { "edgeId" : 100467, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100500, "reactomeId" : 10134136, "displayName" : "Potassium voltage-gated channels (beta cell, open)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1178, "y" : 136 }, "minX" : 1111, "maxX" : 1245, "minY" : 111, "maxY" : 162, "prop" : { "x" : 1111, "y" : 111, "width" : 134, "height" : 51 }, "textPosition" : { "x" : 1114, "y" : 112 }, "connectors" : [ ] }, { "id" : 100341, "reactomeId" : 390627, "displayName" : "ADR, NAd", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 94, "y" : 1090 }, "minX" : 61, "maxX" : 191, "minY" : 1079, "maxY" : 1112, "prop" : { "x" : 61, "y" : 1079, "width" : 67, "height" : 23 }, "textPosition" : { "x" : 61, "y" : 1080 }, "connectors" : [ { "edgeId" : 100339, "type" : "INPUT", "segments" : [ { "from" : { "x" : 134, "y" : 1097 }, "to" : { "x" : 191, "y" : 1112 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100340, "reactomeId" : 10136127, "displayName" : "ADRA2A,C", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 192, "y" : 1072 }, "minX" : 157, "maxX" : 247, "minY" : 1061, "maxY" : 1139, "prop" : { "x" : 157, "y" : 1061, "width" : 70, "height" : 23 }, "textPosition" : { "x" : 157, "y" : 1062 }, "connectors" : [ { "edgeId" : 100339, "type" : "INPUT", "segments" : [ { "from" : { "x" : 191, "y" : 1090 }, "to" : { "x" : 191, "y" : 1112 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100339, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 233, "y" : 1071 }, "to" : { "x" : 246, "y" : 1071 } }, { "from" : { "x" : 246, "y" : 1071 }, "to" : { "x" : 247, "y" : 1135 } }, { "from" : { "x" : 247, "y" : 1135 }, "to" : { "x" : 207, "y" : 1135 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 203, "y" : 1135 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 203, "y" : 1135 } } } ] }, { "id" : 100342, "reactomeId" : 10136129, "displayName" : "ADRA2A,C:ADR,NAd", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 190, "y" : 1182 }, "minX" : 106, "maxX" : 260, "minY" : 1165, "maxY" : 1323, "prop" : { "x" : 126, "y" : 1171, "width" : 128, "height" : 23 }, "textPosition" : { "x" : 126, "y" : 1173 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 254, "y" : 1171 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 254, "y" : 1171 } } }, "connectors" : [ { "edgeId" : 100339, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100343, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 162, "y" : 1197 }, "to" : { "x" : 106, "y" : 1217 } }, { "from" : { "x" : 106, "y" : 1217 }, "to" : { "x" : 107, "y" : 1274 } }, { "from" : { "x" : 107, "y" : 1274 }, "to" : { "x" : 177, "y" : 1317 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 181, "y" : 1319 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 181, "y" : 1319 } } } ] }, { "id" : 100345, "reactomeId" : 10136136, "displayName" : "G-alpha(i,o):GDP:G beta:G gamma", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 191, "y" : 1245 }, "minX" : 129, "maxX" : 260, "minY" : 1221, "maxY" : 1301, "prop" : { "x" : 129, "y" : 1227, "width" : 125, "height" : 37 }, "textPosition" : { "x" : 128, "y" : 1229 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 254, "y" : 1227 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 254, "y" : 1227 } } }, "connectors" : [ { "edgeId" : 100343, "type" : "INPUT", "segments" : [ { "from" : { "x" : 190, "y" : 1267 }, "to" : { "x" : 190, "y" : 1301 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100344, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 297, "y" : 1260 }, "minX" : 190, "maxX" : 319, "minY" : 1244, "maxY" : 1301, "prop" : { "x" : 277, "y" : 1245, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 281, "y" : 1250 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 313, "y" : 1250 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 313, "y" : 1250 } } }, "connectors" : [ { "edgeId" : 100343, "type" : "INPUT", "segments" : [ { "from" : { "x" : 274, "y" : 1267 }, "to" : { "x" : 190, "y" : 1301 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100347, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 297, "y" : 1395 }, "minX" : 190, "maxX" : 319, "minY" : 1354, "maxY" : 1411, "prop" : { "x" : 276, "y" : 1380, "width" : 42, "height" : 31 }, "textPosition" : { "x" : 280, "y" : 1385 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 313, "y" : 1385 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 313, "y" : 1385 } } }, "connectors" : [ { "edgeId" : 100343, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 273, "y" : 1386 }, "to" : { "x" : 190, "y" : 1354 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 265, "y" : 1387 }, "b" : { "x" : 273, "y" : 1386 }, "c" : { "x" : 268, "y" : 1380 }, "type" : "ARROW", "centre" : { "x" : 268, "y" : 1380 } } } ] }, { "id" : 100346, "reactomeId" : 10136122, "displayName" : "G-alpha(i,o):GTP:G-beta:G-gamma", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 191, "y" : 1408 }, "minX" : 128, "maxX" : 261, "minY" : 1354, "maxY" : 1427, "prop" : { "x" : 128, "y" : 1390, "width" : 127, "height" : 37 }, "textPosition" : { "x" : 128, "y" : 1392 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 255, "y" : 1390 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 255, "y" : 1390 } } }, "connectors" : [ { "edgeId" : 100343, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 190, "y" : 1387 }, "to" : { "x" : 190, "y" : 1354 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 186, "y" : 1380 }, "b" : { "x" : 190, "y" : 1387 }, "c" : { "x" : 194, "y" : 1380 }, "type" : "ARROW", "centre" : { "x" : 194, "y" : 1380 } } }, { "edgeId" : 100348, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 100349, "reactomeId" : 10134069, "displayName" : "G-beta:G-gamma (candidates)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 206, "y" : 1634 }, "minX" : 147, "maxX" : 1070, "minY" : 1490, "maxY" : 1716, "prop" : { "x" : 147, "y" : 1616, "width" : 118, "height" : 37 }, "textPosition" : { "x" : 147, "y" : 1618 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 265, "y" : 1616 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 265, "y" : 1616 } } }, "connectors" : [ { "edgeId" : 100352, "type" : "INPUT", "segments" : [ { "from" : { "x" : 268, "y" : 1636 }, "to" : { "x" : 1032, "y" : 1673 } }, { "from" : { "x" : 1032, "y" : 1673 }, "to" : { "x" : 1033, "y" : 1695 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 100352, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 268, "y" : 1633 }, "to" : { "x" : 1066, "y" : 1632 } }, { "from" : { "x" : 1066, "y" : 1632 }, "to" : { "x" : 1066, "y" : 1708 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1066, "y" : 1712 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1066, "y" : 1712 } } }, { "edgeId" : 100348, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 198, "y" : 1613 }, "to" : { "x" : 148, "y" : 1490 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 192, "y" : 1608 }, "b" : { "x" : 198, "y" : 1613 }, "c" : { "x" : 199, "y" : 1605 }, "type" : "ARROW", "centre" : { "x" : 199, "y" : 1605 } } } ] }, { "id" : 100351, "reactomeId" : 10136118, "displayName" : "G alpha (i,o) (candidates)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 223, "y" : 1465 }, "minX" : 154, "maxX" : 265, "minY" : 1447, "maxY" : 1484, "prop" : { "x" : 181, "y" : 1447, "width" : 84, "height" : 37 }, "textPosition" : { "x" : 181, "y" : 1434 }, "connectors" : [ { "edgeId" : 100348, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 175, "y" : 1465 }, "to" : { "x" : 162, "y" : 1465 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 158, "y" : 1466 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 158, "y" : 1466 } } } ] }, { "id" : 100350, "reactomeId" : 10136120, "displayName" : "G-alpha(i,o):GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 243, "y" : 1517 }, "minX" : 148, "maxX" : 303, "minY" : 1490, "maxY" : 1529, "prop" : { "x" : 190, "y" : 1506, "width" : 107, "height" : 23 }, "textPosition" : { "x" : 201, "y" : 1494 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 297, "y" : 1506 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 297, "y" : 1506 } } }, "connectors" : [ { "edgeId" : 100348, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 202, "y" : 1503 }, "to" : { "x" : 148, "y" : 1490 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 194, "y" : 1505 }, "b" : { "x" : 202, "y" : 1503 }, "c" : { "x" : 196, "y" : 1497 }, "type" : "ARROW", "centre" : { "x" : 196, "y" : 1497 } } } ] } ], "edges" : [ { "id" : 100417, "reactomeId" : 10116233, "displayName" : "Glucagon binds to Glucagon receptor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 190, "y" : 606 }, "minX" : 184, "maxX" : 196, "minY" : 583, "maxY" : 630, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 190, "y" : 630 }, "to" : { "x" : 190, "y" : 606 } }, { "from" : { "x" : 190, "y" : 606 }, "to" : { "x" : 190, "y" : 583 } } ], "endShape" : { "a" : { "x" : 194, "y" : 590 }, "b" : { "x" : 190, "y" : 583 }, "c" : { "x" : 186, "y" : 590 }, "type" : "ARROW", "centre" : { "x" : 186, "y" : 590 } }, "reactionShape" : { "a" : { "x" : 184, "y" : 600 }, "b" : { "x" : 196, "y" : 612 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 190, "y" : 606 } }, "inputs" : [ { "id" : 100418, "points" : [ { "x" : 139, "y" : 651 } ] }, { "id" : 100419, "points" : [ { "x" : 190, "y" : 652 } ] } ], "outputs" : [ { "id" : 100420 } ], "catalysts" : [ { "id" : 100419, "points" : [ { "x" : 215, "y" : 664 }, { "x" : 228, "y" : 664 }, { "x" : 228, "y" : 606 } ] } ] }, { "id" : 100352, "reactomeId" : 10136146, "displayName" : "G-beta:G-gamma inhibits Adenylate cyclase", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1066, "y" : 1724 }, "minX" : 1033, "maxX" : 1093, "minY" : 1695, "maxY" : 1730, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1033, "y" : 1695 }, "to" : { "x" : 1066, "y" : 1724 } }, { "from" : { "x" : 1066, "y" : 1724 }, "to" : { "x" : 1093, "y" : 1723 } } ], "endShape" : { "a" : { "x" : 1086, "y" : 1727 }, "b" : { "x" : 1093, "y" : 1723 }, "c" : { "x" : 1086, "y" : 1719 }, "type" : "ARROW", "centre" : { "x" : 1086, "y" : 1719 } }, "reactionShape" : { "a" : { "x" : 1060, "y" : 1718 }, "b" : { "x" : 1072, "y" : 1730 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1066, "y" : 1724 } }, "inputs" : [ { "id" : 100353, "points" : [ { "x" : 1002, "y" : 1705 } ] }, { "id" : 100349, "points" : [ { "x" : 268, "y" : 1636 }, { "x" : 1032, "y" : 1673 } ] } ], "outputs" : [ { "id" : 100354 } ], "catalysts" : [ { "id" : 100349, "points" : [ { "x" : 268, "y" : 1633 }, { "x" : 1066, "y" : 1632 } ] } ] }, { "id" : 100355, "reactomeId" : 10136105, "displayName" : "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2110, "y" : 1695 }, "minX" : 2078, "maxX" : 2139, "minY" : 1689, "maxY" : 1701, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2139, "y" : 1696 }, "to" : { "x" : 2110, "y" : 1695 } }, { "from" : { "x" : 2110, "y" : 1695 }, "to" : { "x" : 2078, "y" : 1694 } } ], "reactionShape" : { "a" : { "x" : 2104, "y" : 1689 }, "b" : { "x" : 2116, "y" : 1701 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2110, "y" : 1695 } }, "inputs" : [ { "id" : 100356, "points" : [ { "x" : 2160, "y" : 1704 } ] }, { "id" : 100357, "points" : [ { "x" : 2163, "y" : 1679 } ] } ], "outputs" : [ { "id" : 100358, "points" : [ { "x" : 2197, "y" : 1296 } ] }, { "id" : 100359, "points" : [ { "x" : 2045, "y" : 1712 } ] }, { "id" : 100360, "points" : [ { "x" : 2057, "y" : 1663 } ] } ], "catalysts" : [ { "id" : 100361, "points" : [ { "x" : 2252, "y" : 1737 }, { "x" : 2186, "y" : 1755 }, { "x" : 2109, "y" : 1754 } ] } ] }, { "id" : 100421, "reactomeId" : 10112090, "displayName" : "cAMP induces dissociation of inactive PKA tetramers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 980, "y" : 472 }, "minX" : 951, "maxX" : 1008, "minY" : 466, "maxY" : 478, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 951, "y" : 471 }, "to" : { "x" : 980, "y" : 472 } }, { "from" : { "x" : 980, "y" : 472 }, "to" : { "x" : 1008, "y" : 471 } } ], "reactionShape" : { "a" : { "x" : 974, "y" : 466 }, "b" : { "x" : 986, "y" : 478 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 980, "y" : 472 } }, "inputs" : [ { "id" : 100422 } ], "outputs" : [ { "id" : 100423, "points" : [ { "x" : 1063, "y" : 510 } ], "stoichiometry" : 2 }, { "id" : 100424, "points" : [ { "x" : 1049, "y" : 443 } ] } ], "catalysts" : [ { "id" : 100422, "points" : [ { "x" : 951, "y" : 486 }, { "x" : 980, "y" : 498 } ] } ] }, { "id" : 100425, "reactomeId" : 10116328, "displayName" : "PhosphoChREBP (Thr 653) is exported to cytosol", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1254, "y" : 535 }, "minX" : 1193, "maxX" : 1381, "minY" : 529, "maxY" : 564, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1381, "y" : 535 }, "to" : { "x" : 1254, "y" : 535 } }, { "from" : { "x" : 1254, "y" : 535 }, "to" : { "x" : 1193, "y" : 564 } } ], "endShape" : { "a" : { "x" : 1198, "y" : 557 }, "b" : { "x" : 1193, "y" : 564 }, "c" : { "x" : 1201, "y" : 565 }, "type" : "ARROW", "centre" : { "x" : 1201, "y" : 565 } }, "reactionShape" : { "a" : { "x" : 1248, "y" : 529 }, "b" : { "x" : 1260, "y" : 541 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1254, "y" : 535 } }, "inputs" : [ { "id" : 100426 } ], "outputs" : [ { "id" : 100427 } ] }, { "id" : 100362, "reactomeId" : 10136108, "displayName" : "Diacylgycerol activates Protein kinase C, alpha type", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1935, "y" : 1701 }, "minX" : 1892, "maxX" : 1977, "minY" : 1695, "maxY" : 1712, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1977, "y" : 1702 }, "to" : { "x" : 1935, "y" : 1701 } }, { "from" : { "x" : 1935, "y" : 1701 }, "to" : { "x" : 1892, "y" : 1712 } } ], "endShape" : { "a" : { "x" : 1898, "y" : 1706 }, "b" : { "x" : 1892, "y" : 1712 }, "c" : { "x" : 1900, "y" : 1714 }, "type" : "ARROW", "centre" : { "x" : 1900, "y" : 1714 } }, "reactionShape" : { "a" : { "x" : 1929, "y" : 1695 }, "b" : { "x" : 1941, "y" : 1707 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1935, "y" : 1701 } }, "inputs" : [ { "id" : 100363, "points" : [ { "x" : 1972, "y" : 1663 } ] }, { "id" : 100359, "points" : [ { "x" : 1996, "y" : 1712 } ] } ], "outputs" : [ { "id" : 100364 } ], "catalysts" : [ { "id" : 100363, "points" : [ { "x" : 1963, "y" : 1663 } ] } ] }, { "id" : 100365, "reactomeId" : 10136094, "displayName" : "Protein kinase C, alpha type phosphorylates MARCKS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1658, "y" : 1694 }, "minX" : 1639, "maxX" : 1675, "minY" : 1688, "maxY" : 1700, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1675, "y" : 1694 }, "to" : { "x" : 1658, "y" : 1694 } }, { "from" : { "x" : 1658, "y" : 1694 }, "to" : { "x" : 1639, "y" : 1694 } } ], "reactionShape" : { "a" : { "x" : 1652, "y" : 1688 }, "b" : { "x" : 1664, "y" : 1700 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1658, "y" : 1694 } }, "inputs" : [ { "id" : 100366, "points" : [ { "x" : 1699, "y" : 1674 } ], "stoichiometry" : 4 }, { "id" : 100367, "points" : [ { "x" : 1704, "y" : 1712 } ] } ], "outputs" : [ { "id" : 100368, "points" : [ { "x" : 1611, "y" : 1674 } ], "stoichiometry" : 4 }, { "id" : 100369, "points" : [ { "x" : 1605, "y" : 1711 } ] } ], "catalysts" : [ { "id" : 100364, "points" : [ { "x" : 1786, "y" : 1748 }, { "x" : 1738, "y" : 1764 }, { "x" : 1660, "y" : 1763 } ] } ] }, { "id" : 100429, "reactomeId" : 10116267, "displayName" : "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 566, "y" : 1016 }, "minX" : 527, "maxX" : 599, "minY" : 1010, "maxY" : 1022, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 527, "y" : 1016 }, "to" : { "x" : 566, "y" : 1016 } }, { "from" : { "x" : 566, "y" : 1016 }, "to" : { "x" : 599, "y" : 1016 } } ], "reactionShape" : { "a" : { "x" : 560, "y" : 1010 }, "b" : { "x" : 572, "y" : 1022 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 566, "y" : 1016 } }, "inputs" : [ { "id" : 100430, "points" : [ { "x" : 488, "y" : 997 } ] }, { "id" : 100431, "points" : [ { "x" : 478, "y" : 1033 } ] } ], "outputs" : [ { "id" : 100432, "points" : [ { "x" : 620, "y" : 1030 } ] }, { "id" : 100433, "points" : [ { "x" : 622, "y" : 1000 } ] } ], "catalysts" : [ { "id" : 100434, "points" : [ { "x" : 566, "y" : 1073 } ] } ] }, { "id" : 100428, "reactomeId" : 10116258, "displayName" : "Nuclear transport of pChREBP (Thr 666) protein", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1256, "y" : 583 }, "minX" : 1227, "maxX" : 1392, "minY" : 550, "maxY" : 589, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1227, "y" : 581 }, "to" : { "x" : 1256, "y" : 583 } }, { "from" : { "x" : 1256, "y" : 583 }, "to" : { "x" : 1392, "y" : 550 } } ], "endShape" : { "a" : { "x" : 1386, "y" : 556 }, "b" : { "x" : 1392, "y" : 550 }, "c" : { "x" : 1384, "y" : 548 }, "type" : "ARROW", "centre" : { "x" : 1384, "y" : 548 } }, "reactionShape" : { "a" : { "x" : 1250, "y" : 577 }, "b" : { "x" : 1262, "y" : 589 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1256, "y" : 583 } }, "inputs" : [ { "id" : 100427 } ], "outputs" : [ { "id" : 100426 } ] }, { "id" : 100435, "reactomeId" : 10116262, "displayName" : "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 484, "y" : 900 }, "minX" : 478, "maxX" : 490, "minY" : 860, "maxY" : 936, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 484, "y" : 936 }, "to" : { "x" : 484, "y" : 900 } }, { "from" : { "x" : 484, "y" : 900 }, "to" : { "x" : 485, "y" : 860 } } ], "reactionShape" : { "a" : { "x" : 478, "y" : 894 }, "b" : { "x" : 490, "y" : 906 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 484, "y" : 900 } }, "inputs" : [ { "id" : 100430, "points" : [ { "x" : 465, "y" : 966 } ] }, { "id" : 100433, "points" : [ { "x" : 622, "y" : 978 } ] } ], "outputs" : [ { "id" : 100436, "points" : [ { "x" : 667, "y" : 787 } ] }, { "id" : 100431, "points" : [ { "x" : 438, "y" : 1022 }, { "x" : 395, "y" : 982 } ] } ], "catalysts" : [ { "id" : 100437, "points" : [ { "x" : 522, "y" : 899 } ] } ] }, { "id" : 100370, "reactomeId" : 10136206, "displayName" : "FFAR1 binds fatty acids", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3095, "y" : 1295 }, "minX" : 3089, "maxX" : 3101, "minY" : 1289, "maxY" : 1341, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3095, "y" : 1296 }, "to" : { "x" : 3095, "y" : 1295 } }, { "from" : { "x" : 3095, "y" : 1295 }, "to" : { "x" : 3095, "y" : 1341 } } ], "endShape" : { "a" : { "x" : 3091, "y" : 1334 }, "b" : { "x" : 3095, "y" : 1341 }, "c" : { "x" : 3099, "y" : 1334 }, "type" : "ARROW", "centre" : { "x" : 3099, "y" : 1334 } }, "reactionShape" : { "a" : { "x" : 3089, "y" : 1289 }, "b" : { "x" : 3101, "y" : 1301 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3095, "y" : 1295 } }, "inputs" : [ { "id" : 100371, "points" : [ { "x" : 3142, "y" : 1296 } ] }, { "id" : 100372, "points" : [ { "x" : 3095, "y" : 1262 } ] } ], "outputs" : [ { "id" : 100373 } ], "catalysts" : [ { "id" : 100372, "points" : [ { "x" : 3108, "y" : 1262 }, { "x" : 3129, "y" : 1277 } ] } ] }, { "id" : 100374, "reactomeId" : 10136363, "displayName" : "FFAR1:FFAR1 ligands activate Gq", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3093, "y" : 1505 }, "minX" : 3087, "maxX" : 3099, "minY" : 1492, "maxY" : 1523, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3093, "y" : 1492 }, "to" : { "x" : 3093, "y" : 1505 } }, { "from" : { "x" : 3093, "y" : 1505 }, "to" : { "x" : 3092, "y" : 1523 } } ], "reactionShape" : { "a" : { "x" : 3087, "y" : 1499 }, "b" : { "x" : 3099, "y" : 1511 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3093, "y" : 1505 } }, "inputs" : [ { "id" : 100375, "points" : [ { "x" : 3090, "y" : 1469 } ] }, { "id" : 100376, "points" : [ { "x" : 3073, "y" : 1489 } ] } ], "outputs" : [ { "id" : 100377, "points" : [ { "x" : 2848, "y" : 1758 }, { "x" : 2910, "y" : 1788 }, { "x" : 3209, "y" : 1789 }, { "x" : 3208, "y" : 1604 } ] }, { "id" : 100378, "points" : [ { "x" : 3074, "y" : 1531 } ] } ], "catalysts" : [ { "id" : 100373, "points" : [ { "x" : 3120, "y" : 1370 }, { "x" : 3163, "y" : 1386 }, { "x" : 3161, "y" : 1505 } ] } ] }, { "id" : 100438, "reactomeId" : 10116260, "displayName" : "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 688, "y" : 903 }, "minX" : 682, "maxX" : 694, "minY" : 860, "maxY" : 933, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 688, "y" : 933 }, "to" : { "x" : 688, "y" : 903 } }, { "from" : { "x" : 688, "y" : 903 }, "to" : { "x" : 689, "y" : 860 } } ], "reactionShape" : { "a" : { "x" : 682, "y" : 897 }, "b" : { "x" : 694, "y" : 909 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 688, "y" : 903 } }, "inputs" : [ { "id" : 100432, "points" : [ { "x" : 663, "y" : 1026 }, { "x" : 714, "y" : 983 } ] }, { "id" : 100433, "points" : [ { "x" : 660, "y" : 968 } ] } ], "outputs" : [ { "id" : 100439, "points" : [ { "x" : 656, "y" : 848 } ] }, { "id" : 100436, "points" : [ { "x" : 692, "y" : 797 } ] } ], "catalysts" : [ { "id" : 100437, "points" : [ { "x" : 599, "y" : 900 } ] } ] }, { "id" : 100440, "reactomeId" : 10116250, "displayName" : "AMP binds to gamma subunit of AMP kinase heterotrimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1948, "y" : 501 }, "minX" : 1911, "maxX" : 1954, "minY" : 495, "maxY" : 507, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1948, "y" : 502 }, "to" : { "x" : 1948, "y" : 501 } }, { "from" : { "x" : 1948, "y" : 501 }, "to" : { "x" : 1911, "y" : 501 } } ], "endShape" : { "a" : { "x" : 1918, "y" : 497 }, "b" : { "x" : 1911, "y" : 501 }, "c" : { "x" : 1918, "y" : 505 }, "type" : "ARROW", "centre" : { "x" : 1918, "y" : 505 } }, "reactionShape" : { "c" : { "x" : 1948, "y" : 501 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1948, "y" : 501 } }, "inputs" : [ { "id" : 100441, "points" : [ { "x" : 1957, "y" : 484 } ] }, { "id" : 100442, "points" : [ { "x" : 1958, "y" : 503 } ] } ], "outputs" : [ { "id" : 100443 } ] }, { "id" : 100379, "reactomeId" : 10134081, "displayName" : "GLP1R binds GLP1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 192, "y" : 902 }, "minX" : 186, "maxX" : 198, "minY" : 881, "maxY" : 908, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 192, "y" : 903 }, "to" : { "x" : 192, "y" : 902 } }, { "from" : { "x" : 192, "y" : 902 }, "to" : { "x" : 192, "y" : 881 } } ], "endShape" : { "a" : { "x" : 196, "y" : 888 }, "b" : { "x" : 192, "y" : 881 }, "c" : { "x" : 188, "y" : 888 }, "type" : "ARROW", "centre" : { "x" : 188, "y" : 888 } }, "reactionShape" : { "a" : { "x" : 186, "y" : 896 }, "b" : { "x" : 198, "y" : 908 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 192, "y" : 902 } }, "inputs" : [ { "id" : 100380, "points" : [ { "x" : 193, "y" : 938 } ] }, { "id" : 100381, "points" : [ { "x" : 125, "y" : 920 } ] } ], "outputs" : [ { "id" : 100382 } ], "catalysts" : [ { "id" : 100381, "points" : [ { "x" : 91, "y" : 920 }, { "x" : 90, "y" : 900 } ] } ] }, { "id" : 100444, "reactomeId" : 10139698, "displayName" : "CD36 (FAT) translocates a long chain fatty acid from the extracellular region to the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3093, "y" : 1160 }, "minX" : 3026, "maxX" : 3161, "minY" : 1154, "maxY" : 1166, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3161, "y" : 1160 }, "to" : { "x" : 3093, "y" : 1160 } }, { "from" : { "x" : 3093, "y" : 1160 }, "to" : { "x" : 3026, "y" : 1160 } } ], "endShape" : { "a" : { "x" : 3033, "y" : 1156 }, "b" : { "x" : 3026, "y" : 1160 }, "c" : { "x" : 3033, "y" : 1164 }, "type" : "ARROW", "centre" : { "x" : 3033, "y" : 1164 } }, "reactionShape" : { "a" : { "x" : 3087, "y" : 1154 }, "b" : { "x" : 3099, "y" : 1166 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3093, "y" : 1160 } }, "inputs" : [ { "id" : 100445 } ], "outputs" : [ { "id" : 100446 } ], "catalysts" : [ { "id" : 100447, "points" : [ { "x" : 3095, "y" : 1131 } ] } ] }, { "id" : 100383, "reactomeId" : 10134138, "displayName" : "Potassium voltage-gated channels close in reponse to PKA", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1063, "y" : 137 }, "minX" : 1036, "maxX" : 1105, "minY" : 131, "maxY" : 143, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1036, "y" : 137 }, "to" : { "x" : 1063, "y" : 137 } }, { "from" : { "x" : 1063, "y" : 137 }, "to" : { "x" : 1105, "y" : 136 } } ], "reactionShape" : { "a" : { "x" : 1057, "y" : 131 }, "b" : { "x" : 1069, "y" : 143 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1063, "y" : 137 } }, "inputs" : [ { "id" : 100384 } ], "catalysts" : [ { "id" : 100385, "points" : [ { "x" : 1062, "y" : 184 } ] } ] }, { "id" : 100448, "reactomeId" : 10139712, "displayName" : "ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2790, "y" : 1400 }, "minX" : 2727, "maxX" : 2826, "minY" : 1394, "maxY" : 1406, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2826, "y" : 1400 }, "to" : { "x" : 2790, "y" : 1400 } }, { "from" : { "x" : 2790, "y" : 1400 }, "to" : { "x" : 2727, "y" : 1400 } } ], "reactionShape" : { "a" : { "x" : 2784, "y" : 1394 }, "b" : { "x" : 2796, "y" : 1406 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2790, "y" : 1400 } }, "inputs" : [ { "id" : 100449, "points" : [ { "x" : 2887, "y" : 1364 } ] }, { "id" : 100450, "points" : [ { "x" : 2884, "y" : 1398 } ] }, { "id" : 100446, "points" : [ { "x" : 2982, "y" : 1180 } ] } ], "outputs" : [ { "id" : 100451, "points" : [ { "x" : 2672, "y" : 1399 } ] }, { "id" : 100452, "points" : [ { "x" : 2682, "y" : 1363 } ] }, { "id" : 100453, "points" : [ { "x" : 2727, "y" : 1355 } ] } ], "catalysts" : [ { "id" : 100454, "points" : [ { "x" : 2791, "y" : 1435 } ] } ] }, { "id" : 100386, "reactomeId" : 10134106, "displayName" : "ER calcium channels open in response to activated PKA", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2565, "y" : 1209 }, "minX" : 2559, "maxX" : 2571, "minY" : 1172, "maxY" : 1253, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2565, "y" : 1172 }, "to" : { "x" : 2565, "y" : 1209 } }, { "from" : { "x" : 2565, "y" : 1209 }, "to" : { "x" : 2565, "y" : 1253 } } ], "endShape" : { "a" : { "x" : 2561, "y" : 1246 }, "b" : { "x" : 2565, "y" : 1253 }, "c" : { "x" : 2569, "y" : 1246 }, "type" : "ARROW", "centre" : { "x" : 2569, "y" : 1246 } }, "reactionShape" : { "a" : { "x" : 2559, "y" : 1203 }, "b" : { "x" : 2571, "y" : 1215 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2565, "y" : 1209 } }, "inputs" : [ { "id" : 100387 } ], "outputs" : [ { "id" : 100388 } ], "catalysts" : [ { "id" : 100389, "points" : [ { "x" : 2613, "y" : 1208 } ] } ] }, { "id" : 100455, "reactomeId" : 10212280, "displayName" : "Meglitinides bind ABCC8", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2764, "y" : 68 }, "minX" : 2725, "maxX" : 2835, "minY" : 62, "maxY" : 120, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2725, "y" : 68 }, "to" : { "x" : 2764, "y" : 68 } }, { "from" : { "x" : 2764, "y" : 68 }, "to" : { "x" : 2835, "y" : 120 } } ], "endShape" : { "a" : { "x" : 2827, "y" : 119 }, "b" : { "x" : 2835, "y" : 120 }, "c" : { "x" : 2832, "y" : 113 }, "type" : "ARROW", "centre" : { "x" : 2832, "y" : 113 } }, "reactionShape" : { "c" : { "x" : 2764, "y" : 68 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2764, "y" : 68 } }, "inputs" : [ { "id" : 100456, "points" : [ { "x" : 2705, "y" : 29 } ] }, { "id" : 100405, "points" : [ { "x" : 2708, "y" : 111 } ] } ], "outputs" : [ { "id" : 100457 } ] }, { "id" : 100390, "reactomeId" : 10134109, "displayName" : "cAMP activates EPAC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1586, "y" : 176 }, "minX" : 1562, "maxX" : 1623, "minY" : 163, "maxY" : 182, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1562, "y" : 175 }, "to" : { "x" : 1586, "y" : 176 } }, { "from" : { "x" : 1586, "y" : 176 }, "to" : { "x" : 1623, "y" : 163 } } ], "endShape" : { "a" : { "x" : 1618, "y" : 169 }, "b" : { "x" : 1623, "y" : 163 }, "c" : { "x" : 1615, "y" : 162 }, "type" : "ARROW", "centre" : { "x" : 1615, "y" : 162 } }, "reactionShape" : { "a" : { "x" : 1580, "y" : 170 }, "b" : { "x" : 1592, "y" : 182 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1586, "y" : 176 } }, "inputs" : [ { "id" : 100391, "points" : [ { "x" : 1522, "y" : 156 } ] }, { "id" : 100392, "points" : [ { "x" : 629, "y" : 246 }, { "x" : 1543, "y" : 214 } ] } ], "outputs" : [ { "id" : 100393 } ], "catalysts" : [ { "id" : 100391, "points" : [ { "x" : 1537, "y" : 140 }, { "x" : 1585, "y" : 140 } ] } ] }, { "id" : 100394, "reactomeId" : 10134046, "displayName" : "cAMP activates EPAC2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1850, "y" : 174 }, "minX" : 1818, "maxX" : 1883, "minY" : 161, "maxY" : 180, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1818, "y" : 174 }, "to" : { "x" : 1850, "y" : 174 } }, { "from" : { "x" : 1850, "y" : 174 }, "to" : { "x" : 1883, "y" : 161 } } ], "endShape" : { "a" : { "x" : 1878, "y" : 167 }, "b" : { "x" : 1883, "y" : 161 }, "c" : { "x" : 1875, "y" : 160 }, "type" : "ARROW", "centre" : { "x" : 1875, "y" : 160 } }, "reactionShape" : { "a" : { "x" : 1844, "y" : 168 }, "b" : { "x" : 1856, "y" : 180 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1850, "y" : 174 } }, "inputs" : [ { "id" : 100395, "points" : [ { "x" : 1787, "y" : 155 } ] }, { "id" : 100392, "points" : [ { "x" : 629, "y" : 247 }, { "x" : 1819, "y" : 275 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 100396 } ], "catalysts" : [ { "id" : 100395, "points" : [ { "x" : 1806, "y" : 140 }, { "x" : 1848, "y" : 140 } ] } ] }, { "id" : 100458, "reactomeId" : 10212286, "displayName" : "SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2919, "y" : 63 }, "minX" : 2913, "maxX" : 2975, "minY" : 57, "maxY" : 121, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2920, "y" : 62 }, "to" : { "x" : 2919, "y" : 63 } }, { "from" : { "x" : 2919, "y" : 63 }, "to" : { "x" : 2975, "y" : 121 } } ], "endShape" : { "a" : { "x" : 2967, "y" : 119 }, "b" : { "x" : 2975, "y" : 121 }, "c" : { "x" : 2973, "y" : 113 }, "type" : "ARROW", "centre" : { "x" : 2973, "y" : 113 } }, "reactionShape" : { "c" : { "x" : 2919, "y" : 63 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2919, "y" : 63 } }, "inputs" : [ { "id" : 100459, "points" : [ { "x" : 2920, "y" : 29 } ] }, { "id" : 100405, "points" : [ { "x" : 2763, "y" : 118 } ] } ], "outputs" : [ { "id" : 100460 } ] }, { "id" : 100461, "reactomeId" : 10214612, "displayName" : "GLP1R binds GLP1R agonists", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 125, "y" : 1001 }, "minX" : 119, "maxX" : 153, "minY" : 995, "maxY" : 1035, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 125, "y" : 1001 }, "to" : { "x" : 125, "y" : 1035 } }, { "from" : { "x" : 125, "y" : 1035 }, "to" : { "x" : 153, "y" : 1031 } } ], "endShape" : { "a" : { "x" : 147, "y" : 1036 }, "b" : { "x" : 153, "y" : 1031 }, "c" : { "x" : 146, "y" : 1028 }, "type" : "ARROW", "centre" : { "x" : 146, "y" : 1028 } }, "reactionShape" : { "c" : { "x" : 125, "y" : 1001 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 125, "y" : 1001 } }, "inputs" : [ { "id" : 100380, "points" : [ { "x" : 143, "y" : 995 } ] }, { "id" : 100462, "points" : [ { "x" : 104, "y" : 997 } ] } ], "outputs" : [ { "id" : 100463 } ] }, { "id" : 100397, "reactomeId" : 10134147, "displayName" : "RAP1A exchanges GDP for GTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2247, "y" : 137 }, "minX" : 2219, "maxX" : 2273, "minY" : 131, "maxY" : 143, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2219, "y" : 137 }, "to" : { "x" : 2247, "y" : 137 } }, { "from" : { "x" : 2247, "y" : 137 }, "to" : { "x" : 2273, "y" : 137 } } ], "reactionShape" : { "a" : { "x" : 2241, "y" : 131 }, "b" : { "x" : 2253, "y" : 143 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2247, "y" : 137 } }, "inputs" : [ { "id" : 100398, "points" : [ { "x" : 2193, "y" : 137 } ] }, { "id" : 100399, "points" : [ { "x" : 2198, "y" : 161 } ] } ], "outputs" : [ { "id" : 100400, "points" : [ { "x" : 2303, "y" : 137 } ] }, { "id" : 100401, "points" : [ { "x" : 2296, "y" : 161 } ] } ], "catalysts" : [ { "id" : 100402, "points" : [ { "x" : 2087, "y" : 115 }, { "x" : 2152, "y" : 95 } ] } ] }, { "id" : 100464, "reactomeId" : 10214700, "displayName" : "FFAR1 binds rosiglitazone", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3152, "y" : 1246 }, "minX" : 3110, "maxX" : 3158, "minY" : 1211, "maxY" : 1252, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3153, "y" : 1247 }, "to" : { "x" : 3152, "y" : 1246 } }, { "from" : { "x" : 3152, "y" : 1246 }, "to" : { "x" : 3110, "y" : 1211 } } ], "endShape" : { "a" : { "x" : 3118, "y" : 1212 }, "b" : { "x" : 3110, "y" : 1211 }, "c" : { "x" : 3113, "y" : 1219 }, "type" : "ARROW", "centre" : { "x" : 3113, "y" : 1219 } }, "reactionShape" : { "c" : { "x" : 3152, "y" : 1246 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3152, "y" : 1246 } }, "inputs" : [ { "id" : 100465, "points" : [ { "x" : 3173, "y" : 1239 } ] }, { "id" : 100372, "points" : [ { "x" : 3121, "y" : 1247 } ] } ], "outputs" : [ { "id" : 100466 } ] }, { "id" : 100467, "reactomeId" : 10197714, "displayName" : "ADIPOQ trimer binds ADIPOR dimers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1377, "y" : 1757 }, "minX" : 1327, "maxX" : 1409, "minY" : 1746, "maxY" : 1763, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1327, "y" : 1757 }, "to" : { "x" : 1377, "y" : 1757 } }, { "from" : { "x" : 1377, "y" : 1757 }, "to" : { "x" : 1409, "y" : 1746 } } ], "endShape" : { "a" : { "x" : 1404, "y" : 1752 }, "b" : { "x" : 1409, "y" : 1746 }, "c" : { "x" : 1401, "y" : 1744 }, "type" : "ARROW", "centre" : { "x" : 1401, "y" : 1744 } }, "reactionShape" : { "a" : { "x" : 1371, "y" : 1751 }, "b" : { "x" : 1383, "y" : 1763 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1377, "y" : 1757 } }, "inputs" : [ { "id" : 100468, "points" : [ { "x" : 1312, "y" : 1740 } ] }, { "id" : 100469, "points" : [ { "x" : 1308, "y" : 1786 } ] } ], "outputs" : [ { "id" : 100470 } ], "catalysts" : [ { "id" : 100469, "points" : [ { "x" : 1352, "y" : 1796 }, { "x" : 1374, "y" : 1795 } ] } ] }, { "id" : 100403, "reactomeId" : 10129292, "displayName" : "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2930, "y" : 193 }, "minX" : 2817, "maxX" : 2969, "minY" : 187, "maxY" : 199, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2817, "y" : 193 }, "to" : { "x" : 2930, "y" : 193 } }, { "from" : { "x" : 2930, "y" : 193 }, "to" : { "x" : 2969, "y" : 193 } } ], "reactionShape" : { "a" : { "x" : 2924, "y" : 187 }, "b" : { "x" : 2936, "y" : 199 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2930, "y" : 193 } }, "inputs" : [ { "id" : 100404, "points" : [ { "x" : 2790, "y" : 208 } ], "stoichiometry" : 4 }, { "id" : 100405, "points" : [ { "x" : 2755, "y" : 168 } ] } ], "outputs" : [ { "id" : 100406, "points" : [ { "x" : 3056, "y" : 178 } ] }, { "id" : 100407, "points" : [ { "x" : 3017, "y" : 220 } ], "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 100405, "points" : [ { "x" : 2763, "y" : 152 } ] } ], "inhibitors" : [ { "id" : 100409, "points" : [ { "x" : 3158, "y" : 320 }, { "x" : 3020, "y" : 287 } ] } ], "activators" : [ { "id" : 100396, "points" : [ { "x" : 1954, "y" : 161 }, { "x" : 2085, "y" : 229 }, { "x" : 2780, "y" : 266 } ] }, { "id" : 100393, "points" : [ { "x" : 1701, "y" : 163 }, { "x" : 1852, "y" : 236 }, { "x" : 2807, "y" : 290 } ] }, { "id" : 100385, "points" : [ { "x" : 1132, "y" : 205 }, { "x" : 2843, "y" : 325 } ] }, { "id" : 100408, "points" : [ { "x" : 2969, "y" : 396 } ] } ] }, { "id" : 100339, "reactomeId" : 10136132, "displayName" : "Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 191, "y" : 1135 }, "minX" : 185, "maxX" : 197, "minY" : 1112, "maxY" : 1168, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 191, "y" : 1112 }, "to" : { "x" : 191, "y" : 1135 } }, { "from" : { "x" : 191, "y" : 1135 }, "to" : { "x" : 190, "y" : 1168 } } ], "endShape" : { "a" : { "x" : 186, "y" : 1161 }, "b" : { "x" : 190, "y" : 1168 }, "c" : { "x" : 194, "y" : 1161 }, "type" : "ARROW", "centre" : { "x" : 194, "y" : 1161 } }, "reactionShape" : { "a" : { "x" : 185, "y" : 1129 }, "b" : { "x" : 197, "y" : 1141 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 191, "y" : 1135 } }, "inputs" : [ { "id" : 100340, "points" : [ { "x" : 191, "y" : 1090 } ] }, { "id" : 100341, "points" : [ { "x" : 134, "y" : 1097 } ] } ], "outputs" : [ { "id" : 100342 } ], "catalysts" : [ { "id" : 100340, "points" : [ { "x" : 233, "y" : 1071 }, { "x" : 246, "y" : 1071 }, { "x" : 247, "y" : 1135 } ] } ] }, { "id" : 100343, "reactomeId" : 10136139, "displayName" : "Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 191, "y" : 1325 }, "minX" : 185, "maxX" : 197, "minY" : 1301, "maxY" : 1354, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 190, "y" : 1301 }, "to" : { "x" : 191, "y" : 1325 } }, { "from" : { "x" : 191, "y" : 1325 }, "to" : { "x" : 190, "y" : 1354 } } ], "reactionShape" : { "a" : { "x" : 185, "y" : 1319 }, "b" : { "x" : 197, "y" : 1331 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 191, "y" : 1325 } }, "inputs" : [ { "id" : 100344, "points" : [ { "x" : 274, "y" : 1267 } ] }, { "id" : 100345, "points" : [ { "x" : 190, "y" : 1267 } ] } ], "outputs" : [ { "id" : 100346, "points" : [ { "x" : 190, "y" : 1387 } ] }, { "id" : 100347, "points" : [ { "x" : 273, "y" : 1386 } ] } ], "catalysts" : [ { "id" : 100342, "points" : [ { "x" : 162, "y" : 1197 }, { "x" : 106, "y" : 1217 }, { "x" : 107, "y" : 1274 } ] } ] }, { "id" : 100410, "reactomeId" : 10129255, "displayName" : "Calcium Influx through Voltage-gated Calcium Channels", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3094, "y" : 1065 }, "minX" : 2671, "maxX" : 3151, "minY" : 1059, "maxY" : 1071, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3151, "y" : 1065 }, "to" : { "x" : 3094, "y" : 1065 } }, { "from" : { "x" : 3094, "y" : 1065 }, "to" : { "x" : 2671, "y" : 1065 } } ], "endShape" : { "a" : { "x" : 2678, "y" : 1061 }, "b" : { "x" : 2671, "y" : 1065 }, "c" : { "x" : 2678, "y" : 1069 }, "type" : "ARROW", "centre" : { "x" : 2678, "y" : 1069 } }, "reactionShape" : { "a" : { "x" : 3088, "y" : 1059 }, "b" : { "x" : 3100, "y" : 1071 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3094, "y" : 1065 } }, "inputs" : [ { "id" : 100411 } ], "outputs" : [ { "id" : 100412 } ], "catalysts" : [ { "id" : 100413, "points" : [ { "x" : 3094, "y" : 1026 } ] } ] }, { "id" : 100348, "reactomeId" : 10136125, "displayName" : "Gi,Go Heterotrimeric G-protein complex dissociates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 146, "y" : 1466 }, "minX" : 140, "maxX" : 176, "minY" : 1430, "maxY" : 1490, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 176, "y" : 1430 }, "to" : { "x" : 146, "y" : 1466 } }, { "from" : { "x" : 146, "y" : 1466 }, "to" : { "x" : 148, "y" : 1490 } } ], "reactionShape" : { "a" : { "x" : 140, "y" : 1460 }, "b" : { "x" : 152, "y" : 1472 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 146, "y" : 1466 } }, "inputs" : [ { "id" : 100346 } ], "outputs" : [ { "id" : 100349, "points" : [ { "x" : 198, "y" : 1613 } ] }, { "id" : 100350, "points" : [ { "x" : 202, "y" : 1503 } ] } ], "catalysts" : [ { "id" : 100351, "points" : [ { "x" : 175, "y" : 1465 } ] } ] }, { "id" : 100414, "reactomeId" : 10143073, "displayName" : "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3095, "y" : 413 }, "minX" : 2994, "maxX" : 3132, "minY" : 407, "maxY" : 419, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3132, "y" : 413 }, "to" : { "x" : 3095, "y" : 413 } }, { "from" : { "x" : 3095, "y" : 413 }, "to" : { "x" : 2994, "y" : 413 } } ], "endShape" : { "a" : { "x" : 3001, "y" : 409 }, "b" : { "x" : 2994, "y" : 413 }, "c" : { "x" : 3001, "y" : 417 }, "type" : "ARROW", "centre" : { "x" : 3001, "y" : 417 } }, "reactionShape" : { "a" : { "x" : 3089, "y" : 407 }, "b" : { "x" : 3101, "y" : 419 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3095, "y" : 413 } }, "inputs" : [ { "id" : 100415 } ], "outputs" : [ { "id" : 100408 } ], "catalysts" : [ { "id" : 100416, "points" : [ { "x" : 3095, "y" : 454 } ] } ] } ], "compartments" : [ { "id" : 100501, "reactomeId" : 216798, "displayName" : "secretory granule", "schemaClass" : "GO_CellularComponent", "renderableClass" : "Compartment", "position" : { "x" : 2884, "y" : 753 }, "minX" : 2759, "maxX" : 3009, "minY" : 600, "maxY" : 907, "prop" : { "x" : 2759, "y" : 600, "width" : 250, "height" : 307 }, "textPosition" : { "x" : 2770, "y" : 858 }, "insets" : { "x" : 2769, "y" : 610, "width" : 230, "height" : 287 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 100502, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2430, "y" : 1210 }, "minX" : 2291, "maxX" : 2569, "minY" : 1064, "maxY" : 1357, "prop" : { "x" : 2291, "y" : 1064, "width" : 278, "height" : 293 }, "textPosition" : { "x" : 2306, "y" : 1235 }, "insets" : { "x" : 2301, "y" : 1074, "width" : 258, "height" : 273 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 100387, 100386, 100388 ] }, { "id" : 100521, "reactomeId" : 17906, "displayName" : "mitochondrial outer membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2733, "y" : 1472 }, "minX" : 2561, "maxX" : 2905, "minY" : 1433, "maxY" : 1512, "prop" : { "x" : 2561, "y" : 1433, "width" : 344, "height" : 79 }, "textPosition" : { "x" : 2638, "y" : 1465 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 100454 ] }, { "id" : 100473, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1642, "y" : 931 }, "minX" : 186, "maxX" : 3099, "minY" : 134, "maxY" : 1729, "prop" : { "x" : 186, "y" : 134, "width" : 2913, "height" : 1595 }, "textPosition" : { "x" : 418, "y" : 1451 }, "insets" : { "x" : 196, "y" : 144, "width" : 2893, "height" : 1575 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 100472, 100427, 100423, 100349, 100352, 100353, 100354, 100340, 100342, 100345, 100343, 100346, 100350, 100344, 100347, 100361, 100355, 100359, 100358, 100362, 100363, 100365, 100366, 100367, 100368, 100369, 100379, 100380, 100382, 100392, 100401, 100394, 100384, 100500, 100385, 100393, 100396, 100399, 100404, 100405, 100406, 100397, 100403, 100420, 100430, 100431, 100432, 100433, 100437, 100439, 100377, 100412, 100413, 100501, 100502, 100408, 100416, 100375, 100372, 100373, 100376, 100378, 100370, 100374, 100410, 100414, 100356, 100357, 100391, 100390, 100395, 100398, 100400, 100421, 100429, 100435, 100438, 100383, 100535, 100434, 100407, 100470, 100468, 100422, 100424, 100417, 100364, 100521, 100436, 100444, 100447, 100448, 100450, 100452, 100457, 100460, 100339, 100463, 100466, 100419, 100536, 100389, 100351, 100360, 100449, 100446, 100451, 100453, 100402 ] }, { "id" : 100472, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1760, "y" : 710 }, "minX" : 1251, "maxX" : 2270, "minY" : 314, "maxY" : 1107, "prop" : { "x" : 1251, "y" : 314, "width" : 1019, "height" : 793 }, "textPosition" : { "x" : 1332, "y" : 667 }, "insets" : { "x" : 1261, "y" : 324, "width" : 999, "height" : 773 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 100426, 100442, 100443, 100441, 100425, 100428, 100440 ] } ], "notes" : [ ], "links" : [ { "id" : 100535, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1070, "y" : 136 }, "minX" : 1036, "maxX" : 1105, "minY" : 130, "maxY" : 142, "segments" : [ { "from" : { "x" : 1036, "y" : 136 }, "to" : { "x" : 1105, "y" : 136 } } ], "reactionShape" : { "a" : { "x" : 1064, "y" : 130 }, "b" : { "x" : 1076, "y" : 142 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1070, "y" : 136 } }, "inputs" : [ { "id" : 100384 } ], "outputs" : [ { "id" : 100500 } ] }, { "id" : 100537, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1953, "y" : 94 }, "minX" : 1934, "maxX" : 2004, "minY" : 88, "maxY" : 118, "segments" : [ { "from" : { "x" : 1934, "y" : 118 }, "to" : { "x" : 1953, "y" : 94 } }, { "from" : { "x" : 1953, "y" : 94 }, "to" : { "x" : 2004, "y" : 115 } } ], "reactionShape" : { "a" : { "x" : 1947, "y" : 88 }, "b" : { "x" : 1959, "y" : 100 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1953, "y" : 94 } }, "inputs" : [ { "id" : 100396 } ], "outputs" : [ { "id" : 100402 } ] }, { "id" : 100538, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1954, "y" : 71 }, "minX" : 1719, "maxX" : 2017, "minY" : 65, "maxY" : 128, "segments" : [ { "from" : { "x" : 1719, "y" : 128 }, "to" : { "x" : 1954, "y" : 71 } }, { "from" : { "x" : 1954, "y" : 71 }, "to" : { "x" : 2017, "y" : 115 } } ], "reactionShape" : { "a" : { "x" : 1948, "y" : 65 }, "b" : { "x" : 1960, "y" : 77 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1954, "y" : 71 } }, "inputs" : [ { "id" : 100393 } ], "outputs" : [ { "id" : 100402 } ] } ], "shadows" : [ { "id" : 100539, "reactomeId" : 10222489, "displayName" : "Glucagon signaling in metabolic regulation", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 608, "y" : 540 }, "minX" : 64, "maxX" : 1152, "minY" : 393, "maxY" : 688, "prop" : { "x" : 64, "y" : 393, "width" : 1088, "height" : 121 }, "points" : [ { "x" : 64, "y" : 393 }, { "x" : 1152, "y" : 393 }, { "x" : 1152, "y" : 688 }, { "x" : 64, "y" : 688 } ], "colour" : "#4684ee" }, { "id" : 100541, "reactomeId" : 10222773, "displayName" : "PKA-mediated phosphorylation of key metabolic factors", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1304, "y" : 557 }, "minX" : 1111, "maxX" : 1497, "minY" : 514, "maxY" : 600, "prop" : { "x" : 1111, "y" : 514, "width" : 386, "height" : 86 }, "points" : [ { "x" : 1111, "y" : 514 }, { "x" : 1497, "y" : 514 }, { "x" : 1497, "y" : 600 }, { "x" : 1111, "y" : 600 } ], "colour" : "#008000" }, { "id" : 100540, "reactomeId" : 10222771, "displayName" : "AMPK inhibits chREBP transcriptional activation activity", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1666, "y" : 1131 }, "minX" : 1246, "maxX" : 2086, "minY" : 440, "maxY" : 1822, "prop" : { "x" : 1246, "y" : 1765, "width" : 840, "height" : 57 }, "points" : [ { "x" : 1246, "y" : 440 }, { "x" : 2086, "y" : 440 }, { "x" : 2086, "y" : 1822 }, { "x" : 1246, "y" : 1822 } ], "colour" : "#dc3912" }, { "id" : 100543, "reactomeId" : 10223465, "displayName" : "Regulation of insulin secretion", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1622, "y" : 877 }, "minX" : -10, "maxX" : 3255, "minY" : -10, "maxY" : 1765, "prop" : { "x" : 2086, "y" : 440, "width" : 1169, "height" : 1325 }, "points" : [ { "x" : -10, "y" : -10 }, { "x" : 3255, "y" : -10 }, { "x" : 3255, "y" : 1765 }, { "x" : -10, "y" : 1765 } ], "colour" : "#4942cc" }, { "id" : 100542, "reactomeId" : 10222775, "displayName" : "Insulin effects increased synthesis of Xylulose-5-Phosphate", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 572, "y" : 931 }, "minX" : 417, "maxX" : 727, "minY" : 753, "maxY" : 1109, "prop" : { "x" : 417, "y" : 753, "width" : 310, "height" : 356 }, "points" : [ { "x" : 417, "y" : 753 }, { "x" : 727, "y" : 753 }, { "x" : 727, "y" : 1109 }, { "x" : 417, "y" : 1109 } ], "colour" : "#666666" } ], "minX" : 0, "maxX" : 3245, "minY" : 0, "maxY" : 1812, "disease" : false }