{
  "dbId" : 10224115,
  "stId" : "R-RNO-1169408",
  "speciesName" : "Rattus norvegicus",
  "nodes" : [ {
    "dbId" : 10151322,
    "stId" : "R-RNO-1169387",
    "displayName" : "ISGylated host proteins [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 50596, 50571 ],
    "parents" : [ ],
    "children" : [ 10151320, 10151243 ]
  }, {
    "dbId" : 10151259,
    "stId" : "R-RNO-1169389",
    "displayName" : "ISGylated IRF3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 50589 ],
    "parents" : [ ],
    "children" : [ 10116942, 10151243 ]
  }, {
    "dbId" : 10151320,
    "stId" : "R-RNO-1169379",
    "displayName" : "ISG15 targets [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48895,
    "diagramIds" : [ 50569 ],
    "parents" : [ 10151322 ],
    "children" : [ 10141013, 10111332, 10151314, 10103551, 10133721, 10125512, 10151307, 10146023, 10151318 ]
  }, {
    "dbId" : 10144921,
    "stId" : "R-RNO-912325",
    "displayName" : "Usp18 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 50598 ],
    "identifier" : "Q6AYC7",
    "standardIdentifier" : "uniprot:Q6AYC7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Usp18" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10133721,
    "stId" : "R-RNO-629622",
    "displayName" : "Stat1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "F1M9D6",
    "standardIdentifier" : "uniprot:F1M9D6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Stat1" ],
    "parents" : [ 10151320 ],
    "children" : [ ]
  }, {
    "dbId" : 10151257,
    "stId" : "R-RNO-1169383",
    "displayName" : "ISG15:UBCH8:ISG15 E3 ligase [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 50576, 50567, 50570 ],
    "parents" : [ ],
    "children" : [ 10151255, 10151245 ]
  }, {
    "dbId" : 10151314,
    "stId" : "R-RNO-1632841",
    "displayName" : "Becn1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q91XJ1",
    "standardIdentifier" : "uniprot:Q91XJ1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Becn1" ],
    "parents" : [ 10151320 ],
    "children" : [ ]
  }, {
    "dbId" : 10151249,
    "stId" : "R-RNO-1678825",
    "displayName" : "Arih1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "D3ZXL1",
    "standardIdentifier" : "uniprot:D3ZXL1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Arih1" ],
    "parents" : [ 10151255 ],
    "children" : [ ]
  }, {
    "dbId" : 10151318,
    "stId" : "R-RNO-947489",
    "displayName" : "MX1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P18589",
    "standardIdentifier" : "uniprot:P18589",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10151320 ],
    "children" : [ ]
  }, {
    "dbId" : 10151255,
    "stId" : "R-RNO-1169381",
    "displayName" : "ISG15 E3 ligases [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48895,
    "diagramIds" : [ 50578, 50566, 50572, 50590 ],
    "parents" : [ 10151257 ],
    "children" : [ 10151249, 10151253 ]
  }, {
    "dbId" : 10225427,
    "stId" : "R-RNO-9833482",
    "displayName" : "PKR-mediated signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 48895,
    "diagramIds" : [ 50607 ]
  }, {
    "dbId" : 10149397,
    "stId" : "R-RNO-936014",
    "displayName" : "Ube2l6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 50563, 50579, 50583, 50573, 50591 ],
    "identifier" : "Q4V8J2",
    "standardIdentifier" : "uniprot:Q4V8J2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ube2l6" ],
    "parents" : [ 10151245 ],
    "children" : [ ]
  }, {
    "dbId" : 10141013,
    "stId" : "R-RNO-451898",
    "displayName" : "JAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "A0A8I6AM23",
    "standardIdentifier" : "uniprot:A0A8I6AM23",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10151320 ],
    "children" : [ ]
  }, {
    "dbId" : 10151253,
    "stId" : "R-RNO-918186",
    "displayName" : "Trim25 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "D4A9N5",
    "standardIdentifier" : "uniprot:D4A9N5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Trim25" ],
    "parents" : [ 10151255 ],
    "children" : [ ]
  }, {
    "dbId" : 10151243,
    "stId" : "R-RNO-936552",
    "displayName" : "Isg15 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 50557 ],
    "identifier" : "D4A3X3",
    "standardIdentifier" : "uniprot:D4A3X3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Isg15" ],
    "parents" : [ 10151299, 10151283, 10151273, 10151277, 10151322, 10151264, 10151245, 10151259 ],
    "children" : [ ]
  }, {
    "dbId" : 10151307,
    "stId" : "R-RNO-168699",
    "displayName" : "EIF2AK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q63184",
    "standardIdentifier" : "uniprot:Q63184",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10151320 ],
    "children" : [ ]
  }, {
    "dbId" : 10125512,
    "stId" : "R-RNO-202320",
    "displayName" : "PLCG1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P10686",
    "standardIdentifier" : "uniprot:P10686",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Plcg1" ],
    "parents" : [ 10151320 ],
    "children" : [ ]
  }, {
    "dbId" : 10116942,
    "stId" : "R-RNO-166251",
    "displayName" : "Irf3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 50588 ],
    "identifier" : "F7EXX5",
    "standardIdentifier" : "uniprot:F7EXX5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Irf3" ],
    "parents" : [ 10151259 ],
    "children" : [ ]
  }, {
    "dbId" : 10151245,
    "stId" : "R-RNO-1169385",
    "displayName" : "ISG15:UBCH8 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 50564 ],
    "parents" : [ 10151257 ],
    "children" : [ 10149397, 10151243 ]
  }, {
    "dbId" : 10151299,
    "stId" : "R-RNO-1169391",
    "displayName" : "ISGylated PP2CB [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 50582 ],
    "parents" : [ ],
    "children" : [ 10151297, 10151243 ]
  }, {
    "dbId" : 10151297,
    "stId" : "R-RNO-1169375",
    "displayName" : "PPM1B [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 50581 ],
    "identifier" : "P35815",
    "standardIdentifier" : "uniprot:P35815",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10151299 ],
    "children" : [ ]
  }, {
    "dbId" : 76577,
    "stId" : "R-ALL-76577",
    "displayName" : "AMP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 50559 ],
    "identifier" : "456215",
    "standardIdentifier" : "chebi:456215",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10103551,
    "stId" : "R-RNO-174100",
    "displayName" : "Ube2e1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "F1M3L4",
    "standardIdentifier" : "uniprot:F1M3L4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ube2e1" ],
    "parents" : [ 10151281, 10151320 ],
    "children" : [ ]
  }, {
    "dbId" : 10151283,
    "stId" : "R-RNO-1169382",
    "displayName" : "ISGylated E2 conjugating enzymes [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 50586 ],
    "parents" : [ ],
    "children" : [ 10151281, 10151243 ]
  }, {
    "dbId" : 10151281,
    "stId" : "R-RNO-1169378",
    "displayName" : "E2 congugating enzymes [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "diagramIds" : [ 50585 ],
    "parents" : [ 10151283 ],
    "children" : [ 10103551, 10117482 ]
  }, {
    "dbId" : 10117482,
    "stId" : "R-RNO-206072",
    "displayName" : "Ube2n [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q9EQX9",
    "standardIdentifier" : "uniprot:Q9EQX9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ube2n" ],
    "parents" : [ 10151281 ],
    "children" : [ ]
  }, {
    "dbId" : 141681,
    "stId" : "R-ALL-141681",
    "displayName" : "polypeptide [cytosol]",
    "schemaClass" : "OtherEntity",
    "speciesId" : 0,
    "diagramIds" : [ 50597 ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10151273,
    "stId" : "R-RNO-1169388",
    "displayName" : "ISGylated Filamin B [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 50577 ],
    "parents" : [ ],
    "children" : [ 10151271, 10151243 ]
  }, {
    "dbId" : 10148844,
    "stId" : "R-RNO-975992",
    "displayName" : "Nedd4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 50593 ],
    "identifier" : "Q62940",
    "standardIdentifier" : "uniprot:Q62940",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Nedd4" ],
    "parents" : [ 10151277 ],
    "children" : [ ]
  }, {
    "dbId" : 10151277,
    "stId" : "R-RNO-1169384",
    "displayName" : "ISG15:NEDD4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 50594 ],
    "parents" : [ ],
    "children" : [ 10148844, 10151243 ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 50556 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10151264,
    "stId" : "R-RNO-1169390",
    "displayName" : "ISG15:UBA7 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 50561 ],
    "parents" : [ ],
    "children" : [ 10149409, 10151243 ]
  }, {
    "dbId" : 10149409,
    "stId" : "R-RNO-936550",
    "displayName" : "Uba7 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 50558 ],
    "identifier" : "A0A0G2K735",
    "standardIdentifier" : "uniprot:A0A0G2K735",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Uba7" ],
    "parents" : [ 10151264 ],
    "children" : [ ]
  }, {
    "dbId" : 10146023,
    "stId" : "R-RNO-168917",
    "displayName" : "DDX58 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "D4ADT5",
    "standardIdentifier" : "uniprot:D4ADT5",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10151320 ],
    "children" : [ ]
  }, {
    "dbId" : 10151271,
    "stId" : "R-RNO-354163",
    "displayName" : "Flnb [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 50575 ],
    "identifier" : "A0A0G2JXT8",
    "standardIdentifier" : "uniprot:A0A0G2JXT8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Flnb" ],
    "parents" : [ 10151273 ],
    "children" : [ ]
  }, {
    "dbId" : 10111332,
    "stId" : "R-RNO-59284",
    "displayName" : "MAPK3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P21708",
    "standardIdentifier" : "uniprot:P21708",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Mapk3", "Erk1", "Prkm3" ],
    "parents" : [ 10151320 ],
    "children" : [ ]
  }, {
    "dbId" : 111294,
    "stId" : "R-ALL-111294",
    "displayName" : "PPi [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 50560 ],
    "identifier" : "33019",
    "standardIdentifier" : "chebi:33019",
    "chebiIdentifier" : "chebi:33019",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10151290,
    "stId" : "R-RNO-1169404",
    "displayName" : "Transfer of ISG15 from E1 to E2 (UBCH8)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10151267 ],
    "following" : [ 10151287 ],
    "inputs" : [ 10149397, 10151264 ],
    "outputs" : [ 10149409, 10151245 ],
    "catalysts" : [ 10149397 ],
    "efs" : [ ],
    "diagramIds" : [ 50562 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10158139,
    "stId" : "R-RNO-1678841",
    "displayName" : "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 10151322 ],
    "outputs" : [ 141681, 10151320 ],
    "catalysts" : [ 10144921 ],
    "efs" : [ ],
    "diagramIds" : [ 50595 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10151275,
    "stId" : "R-RNO-1169398",
    "displayName" : "ISGylation of host protein filamin B",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10151287 ],
    "inputs" : [ 10151271, 10151257 ],
    "outputs" : [ 10149397, 10151255, 10151273 ],
    "catalysts" : [ 10151257 ],
    "efs" : [ ],
    "diagramIds" : [ 50574 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10151262,
    "stId" : "R-RNO-1169394",
    "displayName" : "ISGylation of IRF3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10151287 ],
    "inputs" : [ 10116942, 10151257 ],
    "outputs" : [ 10149397, 10151255, 10151259 ],
    "catalysts" : [ 10151257 ],
    "efs" : [ ],
    "diagramIds" : [ 50587 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10151279,
    "stId" : "R-RNO-1169399",
    "displayName" : "Interaction of ISG15 with NEDD4 and inhibition of Ebola virus budding",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10148844, 10151243 ],
    "outputs" : [ 10151277 ],
    "efs" : [ ],
    "diagramIds" : [ 50592 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10151324,
    "stId" : "R-RNO-1169406",
    "displayName" : "ISGylation of host proteins",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10151287 ],
    "inputs" : [ 10151257, 10151320 ],
    "outputs" : [ 10149397, 10151255, 10151322 ],
    "catalysts" : [ 10151257 ],
    "efs" : [ ],
    "diagramIds" : [ 50568 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10151267,
    "stId" : "R-RNO-1169397",
    "displayName" : "Activation of ISG15 by UBA7 E1 enzyme",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10151290 ],
    "inputs" : [ 10149409, 113592, 10151243 ],
    "outputs" : [ 111294, 10151264, 76577 ],
    "catalysts" : [ 10149409 ],
    "efs" : [ ],
    "diagramIds" : [ 50555 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10151287,
    "stId" : "R-RNO-1169403",
    "displayName" : "Interaction of E3 ligase with ISG15:E2 complex",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10151290 ],
    "following" : [ 10151324, 10151301, 10151285, 10151275, 10151262 ],
    "inputs" : [ 10151255, 10151245 ],
    "outputs" : [ 10151257 ],
    "efs" : [ ],
    "diagramIds" : [ 50565 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10151301,
    "stId" : "R-RNO-1169405",
    "displayName" : "ISGylation of protein phosphatase 1 beta (PP2CB)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10151287 ],
    "inputs" : [ 10151297, 10151257 ],
    "outputs" : [ 10149397, 10151255, 10151299 ],
    "catalysts" : [ 10151257 ],
    "efs" : [ ],
    "diagramIds" : [ 50580 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10151285,
    "stId" : "R-RNO-1169402",
    "displayName" : "ISGylation of E2 conjugating enzymes",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10151287 ],
    "inputs" : [ 10151281, 10151257 ],
    "outputs" : [ 10149397, 10151255, 10151283 ],
    "catalysts" : [ 10151257 ],
    "efs" : [ ],
    "diagramIds" : [ 50584 ],
    "entityFunctionalStatus" : [ ]
  } ]
}