{
  "dbId" : 10222399,
  "stId" : "R-RNO-112409",
  "speciesName" : "Rattus norvegicus",
  "nodes" : [ {
    "dbId" : 10112411,
    "stId" : "R-RNO-59502",
    "displayName" : "MAP2K1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q01986",
    "standardIdentifier" : "uniprot:Q01986",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10112413 ],
    "children" : [ ]
  }, {
    "dbId" : 10111385,
    "stId" : "R-RNO-1112543",
    "displayName" : "phospho-p-Y1034-JAK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "A0A8I6AM23",
    "standardIdentifier" : "uniprot:A0A8I6AM23",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10111395 ],
    "children" : [ ]
  }, {
    "dbId" : 10182687,
    "stId" : "R-RNO-5675363",
    "displayName" : "MAPK monomers and dimers [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "diagramIds" : [ 75161 ],
    "parents" : [ ],
    "children" : [ 10124369, 10124371, 10124365, 10124367 ]
  }, {
    "dbId" : 10112413,
    "stId" : "R-RNO-112336",
    "displayName" : "MAP2K1 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "diagramIds" : [ 75119 ],
    "parents" : [ ],
    "children" : [ 10111356, 10112411 ]
  }, {
    "dbId" : 10111380,
    "stId" : "R-RNO-1112580",
    "displayName" : "phospho-Il6st [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P40190",
    "standardIdentifier" : "uniprot:P40190",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Il6st" ],
    "parents" : [ 10111397 ],
    "children" : [ ]
  }, {
    "dbId" : 113550,
    "stId" : "R-ALL-113550",
    "displayName" : "Pi [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 75162 ],
    "identifier" : "43474",
    "standardIdentifier" : "chebi:43474",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10111371,
    "stId" : "R-RNO-1067638",
    "displayName" : "IL6:IL6R [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10111399 ],
    "children" : [ 10111365, 10111369 ]
  }, {
    "dbId" : 10111369,
    "stId" : "R-RNO-197824",
    "displayName" : "Il6r [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P22273",
    "standardIdentifier" : "uniprot:P22273",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Il6r" ],
    "parents" : [ 10111371 ],
    "children" : [ ]
  }, {
    "dbId" : 10111235,
    "stId" : "R-RNO-162573",
    "displayName" : "phospho-p-Y542,Y580-PTPN11 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P41499",
    "standardIdentifier" : "uniprot:P41499",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Ptpn11" ],
    "parents" : [ 10111411 ],
    "children" : [ ]
  }, {
    "dbId" : 10182656,
    "stId" : "R-RNO-5675205",
    "displayName" : "p-T,Y MAPK monomers and dimers:PEA15 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 75151 ],
    "parents" : [ ],
    "children" : [ 10182646, 10182654 ]
  }, {
    "dbId" : 10111365,
    "stId" : "R-RNO-447100",
    "displayName" : "Il6 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P20607",
    "standardIdentifier" : "uniprot:P20607",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Il6" ],
    "parents" : [ 10111403, 10111371 ],
    "children" : [ ]
  }, {
    "dbId" : 10182713,
    "stId" : "R-RNO-5675349",
    "displayName" : "Dusp8 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "D3ZNK9",
    "standardIdentifier" : "uniprot:D3ZNK9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dusp8" ],
    "parents" : [ 10182723 ],
    "children" : [ ]
  }, {
    "dbId" : 10111422,
    "stId" : "R-RNO-109849",
    "displayName" : "p-S,T-MAP2K2:MAPK1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 75136 ],
    "parents" : [ ],
    "children" : [ 10111420, 10111338 ]
  }, {
    "dbId" : 10182717,
    "stId" : "R-RNO-203793",
    "displayName" : "Dusp10 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "D3ZBG7",
    "standardIdentifier" : "uniprot:D3ZBG7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dusp10" ],
    "parents" : [ 10182723 ],
    "children" : [ ]
  }, {
    "dbId" : 10111420,
    "stId" : "R-RNO-109848",
    "displayName" : "phospho-p-S,T-MAP2K2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 75134 ],
    "identifier" : "P36506",
    "standardIdentifier" : "uniprot:P36506",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10111422, 10111446 ],
    "children" : [ ]
  }, {
    "dbId" : 10111411,
    "stId" : "R-RNO-1112753",
    "displayName" : "IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 75128 ],
    "parents" : [ ],
    "children" : [ 10111409, 10111235 ]
  }, {
    "dbId" : 10182705,
    "stId" : "R-RNO-203796-3",
    "displayName" : "Homologues of DUSP1 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "parents" : [ 10182723 ],
    "children" : [ 10182695, 10182703 ]
  }, {
    "dbId" : 10111409,
    "stId" : "R-RNO-1112594",
    "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10111411 ],
    "children" : [ 10111407 ]
  }, {
    "dbId" : 29356,
    "stId" : "R-ALL-29356",
    "displayName" : "H2O [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 75155, 75160 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10182709,
    "stId" : "R-RNO-5675340",
    "displayName" : "DUSP2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q5M863",
    "standardIdentifier" : "uniprot:Q5M863",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10182723 ],
    "children" : [ ]
  }, {
    "dbId" : 10111403,
    "stId" : "R-RNO-1067687",
    "displayName" : "IL6:IL6R-2 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10111405 ],
    "children" : [ 10111365, 10111401 ]
  }, {
    "dbId" : 10111401,
    "stId" : "R-RNO-1067661",
    "displayName" : "Il6r [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P22273",
    "standardIdentifier" : "uniprot:P22273",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Il6r" ],
    "parents" : [ 10111403 ],
    "children" : [ ]
  }, {
    "dbId" : 10182703,
    "stId" : "R-RNO-203796-2",
    "displayName" : "Dusp1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q64623",
    "standardIdentifier" : "uniprot:Q64623",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dusp1" ],
    "parents" : [ 10182705 ],
    "children" : [ ]
  }, {
    "dbId" : 10111407,
    "stId" : "R-RNO-1112584",
    "displayName" : "IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "parents" : [ 10111409 ],
    "children" : [ 10111399, 10111405 ]
  }, {
    "dbId" : 10111405,
    "stId" : "R-RNO-1112570",
    "displayName" : "IL6:sIL6R:Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10111407 ],
    "children" : [ 10111397, 10111403 ]
  }, {
    "dbId" : 10182691,
    "stId" : "R-RNO-5675342",
    "displayName" : "Dusp5 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "O54838",
    "standardIdentifier" : "uniprot:O54838",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dusp5" ],
    "parents" : [ 10182723 ],
    "children" : [ ]
  }, {
    "dbId" : 113592,
    "stId" : "R-ALL-113592",
    "displayName" : "ATP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 75120, 75138, 75130 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10111395,
    "stId" : "R-RNO-1112596",
    "displayName" : "Activated JAK1, JAK2, TYK2 [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48895,
    "parents" : [ 10111397 ],
    "children" : [ 1168862, 10111385, 10111393 ]
  }, {
    "dbId" : 29370,
    "stId" : "R-ALL-29370",
    "displayName" : "ADP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 75122, 75140, 75132 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10111393,
    "stId" : "R-RNO-1112598",
    "displayName" : "phospho-p-Y1054-TYK2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "D3ZD03",
    "standardIdentifier" : "uniprot:D3ZD03",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10111395 ],
    "children" : [ ]
  }, {
    "dbId" : 29372,
    "stId" : "R-ALL-29372",
    "displayName" : "Pi [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 75157 ],
    "identifier" : "43474",
    "standardIdentifier" : "chebi:43474",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10182695,
    "stId" : "R-RNO-203796",
    "displayName" : "ENSRNOG00000069024 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "A0A8I6AJQ7",
    "standardIdentifier" : "uniprot:A0A8I6AJQ7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ENSRNOG00000069024" ],
    "parents" : [ 10182705 ],
    "children" : [ ]
  }, {
    "dbId" : 10111399,
    "stId" : "R-RNO-1112585",
    "displayName" : "IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10111407 ],
    "children" : [ 10111397, 10111371 ]
  }, {
    "dbId" : 10112421,
    "stId" : "R-RNO-157415",
    "displayName" : "phospho-p-T161-CDK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 75123 ],
    "identifier" : "P39951",
    "standardIdentifier" : "uniprot:P39951",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10111397,
    "stId" : "R-RNO-1112563",
    "displayName" : "Tyrosine phosphorylated IL6ST:Activated JAKs [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10111405, 10111399 ],
    "children" : [ 10111380, 10111395 ]
  }, {
    "dbId" : 10182746,
    "stId" : "R-RNO-5675348",
    "displayName" : "Dusp8 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "D3ZNK9",
    "standardIdentifier" : "uniprot:D3ZNK9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dusp8" ],
    "parents" : [ 10182748 ],
    "children" : [ ]
  }, {
    "dbId" : 10123480,
    "stId" : "R-RNO-109856",
    "displayName" : "p-Y185,Y187 MAPK1 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10123489 ],
    "children" : [ 10117190 ]
  }, {
    "dbId" : 10126168,
    "stId" : "R-RNO-203794",
    "displayName" : "Dusp4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q62767",
    "standardIdentifier" : "uniprot:Q62767",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dusp4" ],
    "parents" : [ 10182723 ],
    "children" : [ ]
  }, {
    "dbId" : 10182744,
    "stId" : "R-RNO-5675334",
    "displayName" : "Dusp10 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "D3ZBG7",
    "standardIdentifier" : "uniprot:D3ZBG7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dusp10" ],
    "parents" : [ 10182748 ],
    "children" : [ ]
  }, {
    "dbId" : 10182748,
    "stId" : "R-RNO-5675365",
    "displayName" : "cytosolic MAPK DUSPs [cytosol]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48895,
    "diagramIds" : [ 75158 ],
    "parents" : [ ],
    "children" : [ 10182740, 10182736, 10182734, 10182742, 10182744, 10182746 ]
  }, {
    "dbId" : 10124371,
    "stId" : "R-RNO-5675359",
    "displayName" : "MAPK3 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10182687 ],
    "children" : [ 10124369 ]
  }, {
    "dbId" : 10182736,
    "stId" : "R-RNO-5675346",
    "displayName" : "DUSP7 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q63340",
    "standardIdentifier" : "uniprot:Q63340",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10182748 ],
    "children" : [ ]
  }, {
    "dbId" : 10124369,
    "stId" : "R-RNO-73724",
    "displayName" : "MAPK3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P21708",
    "standardIdentifier" : "uniprot:P21708",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Mapk3", "Erk1", "Prkm3" ],
    "parents" : [ 10182687, 10124371 ],
    "children" : [ ]
  }, {
    "dbId" : 10111446,
    "stId" : "R-RNO-109854",
    "displayName" : "p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 75139 ],
    "parents" : [ ],
    "children" : [ 10111444, 10111420 ]
  }, {
    "dbId" : 10182742,
    "stId" : "R-RNO-5675336",
    "displayName" : "Dusp16 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "D4A3W6",
    "standardIdentifier" : "uniprot:D4A3W6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dusp16" ],
    "parents" : [ 10182748 ],
    "children" : [ ]
  }, {
    "dbId" : 10111444,
    "stId" : "R-RNO-109853",
    "displayName" : "phospho-p-T185,Y187-MAPK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 75144 ],
    "identifier" : "P63086",
    "standardIdentifier" : "uniprot:P63086",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Mapk1", "Erk2", "Mapk", "Prkm1" ],
    "parents" : [ 10111446, 10136570, 10118217 ],
    "children" : [ ]
  }, {
    "dbId" : 10182740,
    "stId" : "R-RNO-5675351",
    "displayName" : "Dusp9 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q2YDV1",
    "standardIdentifier" : "uniprot:Q2YDV1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dusp9" ],
    "parents" : [ 10182748 ],
    "children" : [ ]
  }, {
    "dbId" : 1168862,
    "stId" : "R-RNO-1168862",
    "displayName" : "p-Y1007-Jak2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q62689",
    "standardIdentifier" : "uniprot:Q62689",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Jak2" ],
    "parents" : [ 10111395 ],
    "children" : [ ]
  }, {
    "dbId" : 10118219,
    "stId" : "R-RNO-1268261",
    "displayName" : "p-T,Y MAPK dimers [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "diagramIds" : [ 75147 ],
    "parents" : [ 10182646 ],
    "children" : [ 10118215, 10118217 ]
  }, {
    "dbId" : 10182730,
    "stId" : "R-RNO-5675357",
    "displayName" : "MAPK3 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10182732 ],
    "children" : [ 10111332 ]
  }, {
    "dbId" : 10111435,
    "stId" : "R-RNO-112374",
    "displayName" : "phospho-p-T286,T292-MAP2K1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q01986",
    "standardIdentifier" : "uniprot:Q01986",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10111437 ],
    "children" : [ ]
  }, {
    "dbId" : 10118217,
    "stId" : "R-RNO-109855",
    "displayName" : "p-T185,Y187 MAPK1 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10118219 ],
    "children" : [ 10111444 ]
  }, {
    "dbId" : 10182728,
    "stId" : "R-RNO-5675354",
    "displayName" : "MAPK1 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10182732 ],
    "children" : [ 10111338 ]
  }, {
    "dbId" : 10111433,
    "stId" : "R-RNO-112339",
    "displayName" : "phospho-p-S218,S222,T286,T292-MAP2K1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q01986",
    "standardIdentifier" : "uniprot:Q01986",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10111437 ],
    "children" : [ ]
  }, {
    "dbId" : 10182734,
    "stId" : "R-RNO-5675343",
    "displayName" : "Dusp6 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q64346",
    "standardIdentifier" : "uniprot:Q64346",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dusp6" ],
    "parents" : [ 10182748 ],
    "children" : [ ]
  }, {
    "dbId" : 10124367,
    "stId" : "R-RNO-5675356",
    "displayName" : "MAPK1 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10182687 ],
    "children" : [ 10124365 ]
  }, {
    "dbId" : 10182732,
    "stId" : "R-RNO-5675361",
    "displayName" : "MAPK monomers and dimers [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "diagramIds" : [ 75156 ],
    "parents" : [ ],
    "children" : [ 10136564, 10182728, 10182730 ]
  }, {
    "dbId" : 10111437,
    "stId" : "R-RNO-112340",
    "displayName" : "p-2T-MAP2K1 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "diagramIds" : [ 75121 ],
    "parents" : [ ],
    "children" : [ 10111433, 10111435 ]
  }, {
    "dbId" : 10124365,
    "stId" : "R-RNO-199960",
    "displayName" : "MAPK1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P63086",
    "standardIdentifier" : "uniprot:P63086",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Mapk1", "Erk2", "Mapk", "Prkm1" ],
    "parents" : [ 10182687, 10124367 ],
    "children" : [ ]
  }, {
    "dbId" : 10111426,
    "stId" : "R-RNO-109842",
    "displayName" : "phospho-p-T202,Y204-MAPK3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 75142 ],
    "identifier" : "P21708",
    "standardIdentifier" : "uniprot:P21708",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Mapk3", "Erk1", "Prkm3" ],
    "parents" : [ 10111428, 10136570, 10118215 ],
    "children" : [ ]
  }, {
    "dbId" : 10182723,
    "stId" : "R-RNO-5675368",
    "displayName" : "nuclear MAPK DUSPs [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48895,
    "diagramIds" : [ 75163 ],
    "parents" : [ ],
    "children" : [ 10182691, 10182709, 10182721, 10182705, 10182717, 10182713, 10126168 ]
  }, {
    "dbId" : 10182721,
    "stId" : "R-RNO-5675337",
    "displayName" : "Dusp16 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "D4A3W6",
    "standardIdentifier" : "uniprot:D4A3W6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dusp16" ],
    "parents" : [ 10182723 ],
    "children" : [ ]
  }, {
    "dbId" : 10117190,
    "stId" : "R-RNO-112354",
    "displayName" : "phospho-p-T185,Y187-MAPK1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P63086",
    "standardIdentifier" : "uniprot:P63086",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Mapk1", "Erk2", "Mapk", "Prkm1" ],
    "parents" : [ 10123480, 10182648 ],
    "children" : [ ]
  }, {
    "dbId" : 10118215,
    "stId" : "R-RNO-109844",
    "displayName" : "p-T202, Y204 MAPK3 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10118219 ],
    "children" : [ 10111426 ]
  }, {
    "dbId" : 10111428,
    "stId" : "R-RNO-109843",
    "displayName" : "p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 75131 ],
    "parents" : [ ],
    "children" : [ 10111426, 10111356 ]
  }, {
    "dbId" : 10136570,
    "stId" : "R-RNO-169289",
    "displayName" : "p-T,Y MAPKs [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "diagramIds" : [ 75146 ],
    "parents" : [ 10182646 ],
    "children" : [ 10111444, 10111426 ]
  }, {
    "dbId" : 10182650,
    "stId" : "R-RNO-5674341",
    "displayName" : "p-T,Y MAPK monomers and dimers [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "diagramIds" : [ 75150 ],
    "parents" : [ ],
    "children" : [ 10123489, 10182648 ]
  }, {
    "dbId" : 10182648,
    "stId" : "R-RNO-5674338",
    "displayName" : "p-T,Y MAPKs [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "parents" : [ 10182650 ],
    "children" : [ 10117190, 10107502 ]
  }, {
    "dbId" : 10111358,
    "stId" : "R-RNO-109838",
    "displayName" : "p-2S-MAP2K1:MAPK3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 75127 ],
    "parents" : [ ],
    "children" : [ 10111332, 10111356 ]
  }, {
    "dbId" : 10182654,
    "stId" : "R-RNO-5675204",
    "displayName" : "Pea15 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 75153 ],
    "identifier" : "Q5U318",
    "standardIdentifier" : "uniprot:Q5U318",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Pea15" ],
    "parents" : [ 10182656 ],
    "children" : [ ]
  }, {
    "dbId" : 10111356,
    "stId" : "R-RNO-109837",
    "displayName" : "phospho-p-S218,S222-MAP2K1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 75125 ],
    "identifier" : "Q01986",
    "standardIdentifier" : "uniprot:Q01986",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10112413, 10111358, 10111428 ],
    "children" : [ ]
  }, {
    "dbId" : 10107504,
    "stId" : "R-RNO-109845",
    "displayName" : "p-T202, Y204 MAPK3 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10123489 ],
    "children" : [ 10107502 ]
  }, {
    "dbId" : 10182646,
    "stId" : "R-RNO-5674340",
    "displayName" : "p-T,Y MAPK monomers and dimers [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "diagramIds" : [ 75149 ],
    "parents" : [ 10182656 ],
    "children" : [ 10118219, 10136570 ]
  }, {
    "dbId" : 10136564,
    "stId" : "R-RNO-169291",
    "displayName" : "MAPKs [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "parents" : [ 10182732 ],
    "children" : [ 10111332, 10111338 ]
  }, {
    "dbId" : 10111338,
    "stId" : "R-RNO-59282",
    "displayName" : "MAPK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 75135 ],
    "identifier" : "P63086",
    "standardIdentifier" : "uniprot:P63086",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Mapk1", "Erk2", "Mapk", "Prkm1" ],
    "parents" : [ 10182728, 10111422, 10136564 ],
    "children" : [ ]
  }, {
    "dbId" : 10107502,
    "stId" : "R-RNO-112359",
    "displayName" : "phospho-p-T202,Y204-MAPK3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P21708",
    "standardIdentifier" : "uniprot:P21708",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Mapk3", "Erk1", "Prkm3" ],
    "parents" : [ 10107504, 10182648 ],
    "children" : [ ]
  }, {
    "dbId" : 10123489,
    "stId" : "R-RNO-198701",
    "displayName" : "p-T,Y MAPK dimers [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48895,
    "parents" : [ 10182650 ],
    "children" : [ 10107504, 10123480 ]
  }, {
    "dbId" : 10111332,
    "stId" : "R-RNO-59284",
    "displayName" : "MAPK3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 75126 ],
    "identifier" : "P21708",
    "standardIdentifier" : "uniprot:P21708",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Mapk3", "Erk1", "Prkm3" ],
    "parents" : [ 10182730, 10111358, 10136564 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10111451,
    "stId" : "R-RNO-109863",
    "displayName" : "Dissociation of p-T,Y-MAPK3:MAP2K1",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10111439 ],
    "following" : [ 10182644 ],
    "inputs" : [ 10111428 ],
    "outputs" : [ 10111426, 10111356 ],
    "efs" : [ ],
    "diagramIds" : [ 75141 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10112424,
    "stId" : "R-RNO-112342",
    "displayName" : "Inactivation of MAP2K1 by CDK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 113592, 10112413 ],
    "outputs" : [ 29370, 10111437 ],
    "catalysts" : [ 10112421 ],
    "efs" : [ ],
    "diagramIds" : [ 75118 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10111449,
    "stId" : "R-RNO-109862",
    "displayName" : "MAP2K2 phosphorylates MAPK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10111424 ],
    "following" : [ 10111453 ],
    "inputs" : [ 113592, 10111422 ],
    "outputs" : [ 10111446, 29370 ],
    "catalysts" : [ 10111422 ],
    "efs" : [ ],
    "diagramIds" : [ 75137 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10182751,
    "stId" : "R-RNO-5675376",
    "displayName" : "Cytosolic DUSPs dephosphorylate MAPKs",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10182644 ],
    "inputs" : [ 10182646, 29356 ],
    "outputs" : [ 29372, 10182732 ],
    "catalysts" : [ 10182748 ],
    "efs" : [ ],
    "diagramIds" : [ 75154 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10111439,
    "stId" : "R-RNO-109860",
    "displayName" : "MAP2K1 phosphorylates MAPK3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10111413 ],
    "following" : [ 10111451 ],
    "inputs" : [ 113592, 10111358 ],
    "outputs" : [ 10111428, 29370 ],
    "catalysts" : [ 10111358 ],
    "efs" : [ ],
    "inhibitors" : [ 10111437 ],
    "diagramIds" : [ 75129 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10182685,
    "stId" : "R-RNO-5675206",
    "displayName" : "PEA15 binds MAPK monomers and dimers",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10182644 ],
    "inputs" : [ 10182646, 10182654 ],
    "outputs" : [ 10182656 ],
    "efs" : [ ],
    "diagramIds" : [ 75152 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10111453,
    "stId" : "R-RNO-109864",
    "displayName" : "Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10111449 ],
    "following" : [ 10182644 ],
    "inputs" : [ 10111446 ],
    "outputs" : [ 10111444, 10111420 ],
    "efs" : [ ],
    "diagramIds" : [ 75143 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10182658,
    "stId" : "R-RNO-5674387",
    "displayName" : "Phosphorylated MAPKs translocate into the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10182644 ],
    "following" : [ 10182726 ],
    "inputs" : [ 10182646 ],
    "outputs" : [ 10182650 ],
    "efs" : [ ],
    "inhibitors" : [ 10182656 ],
    "diagramIds" : [ 75148 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10111424,
    "stId" : "R-RNO-109858",
    "displayName" : "MAP2K2 binds MAPK1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10111449 ],
    "inputs" : [ 10111420, 10111338 ],
    "outputs" : [ 10111422 ],
    "efs" : [ ],
    "activators" : [ 10111411 ],
    "diagramIds" : [ 75133 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10182726,
    "stId" : "R-RNO-5675373",
    "displayName" : "Nuclear DUSPs dephosphorylate MAPKs",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10182658 ],
    "inputs" : [ 29356, 10182650 ],
    "outputs" : [ 113550, 10182687 ],
    "catalysts" : [ 10182723 ],
    "efs" : [ ],
    "diagramIds" : [ 75159 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10111413,
    "stId" : "R-RNO-109857",
    "displayName" : "MAP2K1 binds MAPK3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10111439 ],
    "inputs" : [ 10111332, 10111356 ],
    "outputs" : [ 10111358 ],
    "efs" : [ ],
    "activators" : [ 10111411 ],
    "diagramIds" : [ 75124 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10182644,
    "stId" : "R-RNO-5674385",
    "displayName" : "p-T,Y MAPKs dimerize",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10111453, 10111451 ],
    "following" : [ 10182751, 10182685, 10182658 ],
    "inputs" : [ 10136570 ],
    "outputs" : [ 10118219 ],
    "efs" : [ ],
    "diagramIds" : [ 75145 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10222397,
    "stId" : "R-RNO-110056",
    "displayName" : "MAPK3 (ERK1) activation",
    "events" : [ 10111451, 10112424, 10111439, 10111413 ]
  }, {
    "dbId" : 10222405,
    "stId" : "R-RNO-112411",
    "displayName" : "MAPK1 (ERK2) activation",
    "events" : [ 10111449, 10111453, 10111424 ]
  } ]
}