{ "dbId" : 11129174, "stableId" : "R-PFA-8856828", "displayName" : "Clathrin-mediated endocytosis", "nodes" : [ { "id" : 72337, "reactomeId" : 11129172, "displayName" : "Cargo recognition for clathrin-mediated endocytosis", "schemaClass" : "Pathway", "renderableClass" : "ProcessNode", "position" : { "x" : 1573, "y" : 41 }, "minX" : 1487, "maxX" : 1660, "minY" : 0, "maxY" : 83, "prop" : { "x" : 1487, "y" : 0, "width" : 173, "height" : 83 }, "textPosition" : { "x" : 1497, "y" : 13 }, "connectors" : [ ] }, { "id" : 72336, "reactomeId" : 11116186, "displayName" : "PIP5K1C", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 160, "y" : 515 }, "minX" : 93, "maxX" : 204, "minY" : 327, "maxY" : 534, "prop" : { "x" : 123, "y" : 496, "width" : 75, "height" : 38 }, "textPosition" : { "x" : 131, "y" : 504 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 198, "y" : 496 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 198, "y" : 496 } } }, "connectors" : [ { "edgeId" : 72331, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 153, "y" : 493 }, "to" : { "x" : 98, "y" : 335 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 97, "y" : 331 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 97, "y" : 331 } } } ] }, { "id" : 72341, "reactomeId" : 11124609, "displayName" : "AP-2:cargo", "schemaClass" : "Complex", "renderableClass" : "EntitySet", "position" : { "x" : 1578, "y" : 279 }, "minX" : 1511, "maxX" : 1646, "minY" : 259, "maxY" : 299, "prop" : { "x" : 1511, "y" : 259, "width" : 135, "height" : 40 }, "textPosition" : { "x" : 1540, "y" : 268 }, "connectors" : [ ] }, { "id" : 72333, "reactomeId" : 392417, "displayName" : "PI4P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 54, "y" : 387 }, "minX" : 24, "maxX" : 85, "minY" : 341, "maxY" : 406, "prop" : { "x" : 24, "y" : 368, "width" : 60, "height" : 38 }, "textPosition" : { "x" : 36, "y" : 376 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 79, "y" : 373 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 79, "y" : 373 } } }, "connectors" : [ { "edgeId" : 72331, "type" : "INPUT", "segments" : [ { "from" : { "x" : 65, "y" : 365 }, "to" : { "x" : 83, "y" : 341 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 72332, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 22, "y" : 321 }, "minX" : 0, "maxX" : 83, "minY" : 303, "maxY" : 341, "prop" : { "x" : 0, "y" : 304, "width" : 45, "height" : 34 }, "textPosition" : { "x" : 7, "y" : 310 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 40, "y" : 309 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 40, "y" : 309 } } }, "connectors" : [ { "edgeId" : 72331, "type" : "INPUT", "segments" : [ { "from" : { "x" : 48, "y" : 328 }, "to" : { "x" : 83, "y" : 341 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 72335, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 62, "y" : 248 }, "minX" : 42, "maxX" : 107, "minY" : 232, "maxY" : 292, "prop" : { "x" : 42, "y" : 233, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 45, "y" : 237 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 77, "y" : 238 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 77, "y" : 238 } } }, "connectors" : [ { "edgeId" : 72331, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 77, "y" : 266 }, "to" : { "x" : 107, "y" : 292 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 85, "y" : 268 }, "b" : { "x" : 77, "y" : 266 }, "c" : { "x" : 80, "y" : 274 }, "type" : "ARROW", "centre" : { "x" : 80, "y" : 274 } } } ] }, { "id" : 72334, "reactomeId" : 179856, "displayName" : "PI(4,5)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 143, "y" : 244 }, "minX" : 105, "maxX" : 182, "minY" : 227, "maxY" : 292, "prop" : { "x" : 105, "y" : 228, "width" : 76, "height" : 32 }, "textPosition" : { "x" : 110, "y" : 233 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 176, "y" : 233 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 176, "y" : 233 } } }, "connectors" : [ { "edgeId" : 72331, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 131, "y" : 263 }, "to" : { "x" : 107, "y" : 292 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 130, "y" : 271 }, "b" : { "x" : 131, "y" : 263 }, "c" : { "x" : 124, "y" : 266 }, "type" : "ARROW", "centre" : { "x" : 124, "y" : 266 } } } ] } ], "edges" : [ { "id" : 72331, "reactomeId" : 11124754, "displayName" : "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 93, "y" : 320 }, "minX" : 83, "maxX" : 107, "minY" : 292, "maxY" : 341, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 83, "y" : 341 }, "to" : { "x" : 93, "y" : 320 } }, { "from" : { "x" : 93, "y" : 320 }, "to" : { "x" : 107, "y" : 292 } } ], "reactionShape" : { "a" : { "x" : 87, "y" : 314 }, "b" : { "x" : 99, "y" : 326 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 93, "y" : 320 } }, "inputs" : [ { "id" : 72332, "points" : [ { "x" : 48, "y" : 328 } ] }, { "id" : 72333, "points" : [ { "x" : 65, "y" : 365 } ] } ], "outputs" : [ { "id" : 72334, "points" : [ { "x" : 131, "y" : 263 } ] }, { "id" : 72335, "points" : [ { "x" : 77, "y" : 266 } ] } ], "catalysts" : [ { "id" : 72336, "points" : [ { "x" : 153, "y" : 493 } ] } ] } ], "compartments" : [ { "id" : 72338, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1902, "y" : 814 }, "minX" : 25, "maxX" : 3780, "minY" : 204, "maxY" : 1425, "prop" : { "x" : 25, "y" : 204, "width" : 3755, "height" : 1221 }, "textPosition" : { "x" : 999, "y" : 1018 }, "insets" : { "x" : 35, "y" : 214, "width" : 3735, "height" : 1201 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 72334, 72341, 72333, 72331, 72335, 72332, 72346, 72336 ] }, { "id" : 72346, "reactomeId" : 20592, "displayName" : "clathrin-coated endocytic vesicle", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2587, "y" : 1142 }, "minX" : 1618, "maxX" : 3557, "minY" : 986, "maxY" : 1299, "prop" : { "x" : 1618, "y" : 986, "width" : 1939, "height" : 313 }, "textPosition" : { "x" : 2824, "y" : 1128 }, "insets" : { "x" : 1628, "y" : 996, "width" : 1919, "height" : 293 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } } ], "notes" : [ ], "links" : [ { "id" : 72358, "renderableClass" : "Interaction", "position" : { "x" : 1575, "y" : 169 }, "minX" : 1569, "maxX" : 1581, "minY" : 86, "maxY" : 253, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1573, "y" : 86 }, "to" : { "x" : 1577, "y" : 253 } } ], "endShape" : { "a" : { "x" : 1573, "y" : 246 }, "b" : { "x" : 1577, "y" : 253 }, "c" : { "x" : 1581, "y" : 246 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1581, "y" : 246 } }, "reactionShape" : { "a" : { "x" : 1569, "y" : 163 }, "b" : { "x" : 1581, "y" : 175 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1575, "y" : 169 } }, "inputs" : [ { "id" : 72337 } ], "outputs" : [ { "id" : 72341 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 3780, "minY" : 0, "maxY" : 1425, "disease" : false }