{
  "dbId" : 11128972,
  "stableId" : "R-PFA-5621481",
  "displayName" : "C-type lectin receptors (CLRs)",
  "nodes" : [ {
    "id" : 32487,
    "reactomeId" : 11118463,
    "displayName" : "phospho-p-Y753,Y759-PLCG2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 945,
      "y" : 108
    },
    "minX" : 898,
    "maxX" : 998,
    "minY" : 86,
    "maxY" : 125,
    "prop" : {
      "x" : 898,
      "y" : 92,
      "width" : 94,
      "height" : 33
    },
    "textPosition" : {
      "x" : 905,
      "y" : 84
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 992,
          "y" : 92
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 992,
          "y" : 92
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 32486,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 32488,
    "reactomeId" : 11118458,
    "displayName" : "phospho-p-Y753,Y759-PLCG2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1086,
      "y" : 43
    },
    "minX" : 1036,
    "maxX" : 1267,
    "minY" : 0,
    "maxY" : 67,
    "prop" : {
      "x" : 1036,
      "y" : 25,
      "width" : 101,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1047,
      "y" : 19
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1137,
          "y" : 25
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1137,
          "y" : 25
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 32486,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 32489,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1085,
          "y" : 22
        },
        "to" : {
          "x" : 1085,
          "y" : 0
        }
      }, {
        "from" : {
          "x" : 1085,
          "y" : 0
        },
        "to" : {
          "x" : 1262,
          "y" : 0
        }
      }, {
        "from" : {
          "x" : 1262,
          "y" : 0
        },
        "to" : {
          "x" : 1263,
          "y" : 59
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1263,
          "y" : 63
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1263,
          "y" : 63
        }
      }
    } ]
  }, {
    "id" : 32490,
    "reactomeId" : 179856,
    "displayName" : "PI(4,5)P2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1195,
      "y" : 42
    },
    "minX" : 1160,
    "maxX" : 1232,
    "minY" : 26,
    "maxY" : 75,
    "prop" : {
      "x" : 1160,
      "y" : 27,
      "width" : 71,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1163,
      "y" : 31
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1226,
          "y" : 32
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1226,
          "y" : 32
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 32489,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1207,
          "y" : 60
        },
        "to" : {
          "x" : 1223,
          "y" : 75
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 32491,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1188,
      "y" : 126
    },
    "minX" : 1166,
    "maxX" : 1223,
    "minY" : 75,
    "maxY" : 141,
    "prop" : {
      "x" : 1166,
      "y" : 111,
      "width" : 45,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1171,
      "y" : 115
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1206,
          "y" : 116
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1206,
          "y" : 116
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 32489,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1198,
          "y" : 108
        },
        "to" : {
          "x" : 1223,
          "y" : 75
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 32492,
    "reactomeId" : 114520,
    "displayName" : "I(1,4,5)P3",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1339,
      "y" : 127
    },
    "minX" : 1290,
    "maxX" : 1379,
    "minY" : 75,
    "maxY" : 142,
    "prop" : {
      "x" : 1301,
      "y" : 112,
      "width" : 77,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1305,
      "y" : 116
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1373,
          "y" : 117
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1373,
          "y" : 117
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 32489,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1324,
          "y" : 109
        },
        "to" : {
          "x" : 1290,
          "y" : 75
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1316,
          "y" : 107
        },
        "b" : {
          "x" : 1324,
          "y" : 109
        },
        "c" : {
          "x" : 1322,
          "y" : 101
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1322,
          "y" : 101
        }
      }
    } ]
  }, {
    "id" : 32493,
    "reactomeId" : 112275,
    "displayName" : "DAGs",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1329,
      "y" : 42
    },
    "minX" : 1290,
    "maxX" : 1356,
    "minY" : 26,
    "maxY" : 75,
    "prop" : {
      "x" : 1303,
      "y" : 27,
      "width" : 52,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1308,
      "y" : 31
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1350,
          "y" : 32
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1350,
          "y" : 32
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 32489,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1311,
          "y" : 60
        },
        "to" : {
          "x" : 1290,
          "y" : 75
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1308,
          "y" : 67
        },
        "b" : {
          "x" : 1311,
          "y" : 60
        },
        "c" : {
          "x" : 1303,
          "y" : 61
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1303,
          "y" : 61
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 32486,
    "reactomeId" : 11118465,
    "displayName" : "p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1035,
      "y" : 107
    },
    "minX" : 995,
    "maxX" : 1071,
    "minY" : 64,
    "maxY" : 113,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 995,
        "y" : 107
      },
      "to" : {
        "x" : 1035,
        "y" : 107
      }
    }, {
      "from" : {
        "x" : 1035,
        "y" : 107
      },
      "to" : {
        "x" : 1071,
        "y" : 64
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1070,
        "y" : 72
      },
      "b" : {
        "x" : 1071,
        "y" : 64
      },
      "c" : {
        "x" : 1063,
        "y" : 67
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1063,
        "y" : 67
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1029,
        "y" : 101
      },
      "b" : {
        "x" : 1041,
        "y" : 113
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1035,
        "y" : 107
      }
    },
    "inputs" : [ {
      "id" : 32487
    } ],
    "outputs" : [ {
      "id" : 32488
    } ]
  }, {
    "id" : 32489,
    "reactomeId" : 11118461,
    "displayName" : "p-Y753,Y759-PLCG2 hydrolyses PIP2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1263,
      "y" : 75
    },
    "minX" : 1223,
    "maxX" : 1290,
    "minY" : 69,
    "maxY" : 81,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1223,
        "y" : 75
      },
      "to" : {
        "x" : 1263,
        "y" : 75
      }
    }, {
      "from" : {
        "x" : 1263,
        "y" : 75
      },
      "to" : {
        "x" : 1290,
        "y" : 75
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1257,
        "y" : 69
      },
      "b" : {
        "x" : 1269,
        "y" : 81
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1263,
        "y" : 75
      }
    },
    "inputs" : [ {
      "id" : 32490,
      "points" : [ {
        "x" : 1207,
        "y" : 60
      } ]
    }, {
      "id" : 32491,
      "points" : [ {
        "x" : 1198,
        "y" : 108
      } ]
    } ],
    "outputs" : [ {
      "id" : 32492,
      "points" : [ {
        "x" : 1324,
        "y" : 109
      } ]
    }, {
      "id" : 32493,
      "points" : [ {
        "x" : 1311,
        "y" : 60
      } ]
    } ],
    "catalysts" : [ {
      "id" : 32488,
      "points" : [ {
        "x" : 1085,
        "y" : 22
      }, {
        "x" : 1085,
        "y" : 0
      }, {
        "x" : 1262,
        "y" : 0
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 32560,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1626,
      "y" : 1586
    },
    "minX" : 1481,
    "maxX" : 1772,
    "minY" : 1538,
    "maxY" : 1634,
    "prop" : {
      "x" : 1481,
      "y" : 1538,
      "width" : 291,
      "height" : 96
    },
    "textPosition" : {
      "x" : 1597,
      "y" : 1569
    },
    "insets" : {
      "x" : 1491,
      "y" : 1548,
      "width" : 271,
      "height" : 76
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 32535,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1801,
      "y" : 1026
    },
    "minX" : 1297,
    "maxX" : 2306,
    "minY" : 814,
    "maxY" : 1238,
    "prop" : {
      "x" : 1297,
      "y" : 814,
      "width" : 1009,
      "height" : 424
    },
    "textPosition" : {
      "x" : 1653,
      "y" : 991
    },
    "insets" : {
      "x" : 1307,
      "y" : 824,
      "width" : 989,
      "height" : 404
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 32505,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1994,
      "y" : 753
    },
    "minX" : 179,
    "maxX" : 3809,
    "minY" : 43,
    "maxY" : 1463,
    "prop" : {
      "x" : 179,
      "y" : 43,
      "width" : 3630,
      "height" : 1420
    },
    "textPosition" : {
      "x" : 714,
      "y" : 554
    },
    "insets" : {
      "x" : 189,
      "y" : 53,
      "width" : 3610,
      "height" : 1400
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 32487, 32488, 32490, 32491, 32492, 32493, 32525, 32535, 32486, 32489, 32565, 32547, 32567 ]
  }, {
    "id" : 32525,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1331,
      "y" : 374
    },
    "minX" : 1208,
    "maxX" : 1455,
    "minY" : 280,
    "maxY" : 468,
    "prop" : {
      "x" : 1208,
      "y" : 280,
      "width" : 247,
      "height" : 188
    },
    "textPosition" : {
      "x" : 1248,
      "y" : 418
    },
    "insets" : {
      "x" : 1218,
      "y" : 290,
      "width" : 227,
      "height" : 168
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ {
    "id" : 32561,
    "reactomeId" : 11128970,
    "displayName" : "CLEC7A (Dectin-1) signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1138,
      "y" : 83
    },
    "minX" : 888,
    "maxX" : 1388,
    "minY" : 15,
    "maxY" : 152,
    "prop" : {
      "x" : 888,
      "y" : 15,
      "width" : 500,
      "height" : 137
    },
    "points" : [ {
      "x" : 888,
      "y" : 15
    }, {
      "x" : 1388,
      "y" : 15
    }, {
      "x" : 1388,
      "y" : 152
    }, {
      "x" : 888,
      "y" : 152
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 3809,
  "minY" : 0,
  "maxY" : 1634,
  "disease" : false
}