{
  "dbId" : 11128974,
  "stableId" : "R-PFA-5610787",
  "displayName" : "Hedgehog 'off' state",
  "nodes" : [ {
    "id" : 38097,
    "reactomeId" : 30389,
    "displayName" : "cAMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1336,
      "y" : 546
    },
    "minX" : 1273,
    "maxX" : 1361,
    "minY" : 530,
    "maxY" : 561,
    "prop" : {
      "x" : 1312,
      "y" : 531,
      "width" : 48,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1315,
      "y" : 535
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1355,
          "y" : 536
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1355,
          "y" : 536
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38096,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1309,
          "y" : 543
        },
        "to" : {
          "x" : 1273,
          "y" : 540
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1285,
            "y" : 535
          },
          "b" : {
            "x" : 1297,
            "y" : 547
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1291,
            "y" : 541
          }
        }
      }
    } ]
  }, {
    "id" : 38098,
    "reactomeId" : 11118528,
    "displayName" : "PKA tetramer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1287,
      "y" : 505
    },
    "minX" : 1237,
    "maxX" : 1343,
    "minY" : 488,
    "maxY" : 540,
    "prop" : {
      "x" : 1237,
      "y" : 494,
      "width" : 100,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1242,
      "y" : 496
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1337,
          "y" : 494
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1337,
          "y" : 494
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38096,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1282,
          "y" : 520
        },
        "to" : {
          "x" : 1273,
          "y" : 540
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 38099,
    "reactomeId" : 11118520,
    "displayName" : "Homologues of PRKACA",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1276,
      "y" : 769
    },
    "minX" : 1149,
    "maxX" : 1332,
    "minY" : 539,
    "maxY" : 788,
    "prop" : {
      "x" : 1220,
      "y" : 750,
      "width" : 112,
      "height" : 38
    },
    "textPosition" : {
      "x" : 1223,
      "y" : 751
    },
    "connectors" : [ {
      "edgeId" : 38096,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1254,
          "y" : 744
        },
        "to" : {
          "x" : 1149,
          "y" : 656
        }
      }, {
        "from" : {
          "x" : 1149,
          "y" : 656
        },
        "to" : {
          "x" : 1200,
          "y" : 539
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1195,
            "y" : 694
          },
          "b" : {
            "x" : 1207,
            "y" : 706
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1201,
            "y" : 700
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1246,
          "y" : 743
        },
        "b" : {
          "x" : 1254,
          "y" : 744
        },
        "c" : {
          "x" : 1251,
          "y" : 736
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1251,
          "y" : 736
        }
      }
    } ]
  }, {
    "id" : 38100,
    "reactomeId" : 11118530,
    "displayName" : "PKA regulatory subunits:cAMP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1103,
      "y" : 500
    },
    "minX" : 1046,
    "maxX" : 1200,
    "minY" : 475,
    "maxY" : 539,
    "prop" : {
      "x" : 1046,
      "y" : 481,
      "width" : 114,
      "height" : 39
    },
    "textPosition" : {
      "x" : 1051,
      "y" : 485
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1160,
          "y" : 481
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1160,
          "y" : 481
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38096,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1151,
          "y" : 523
        },
        "to" : {
          "x" : 1200,
          "y" : 539
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1169,
            "y" : 525
          },
          "b" : {
            "x" : 1181,
            "y" : 537
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1175,
            "y" : 531
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1159,
          "y" : 521
        },
        "b" : {
          "x" : 1151,
          "y" : 523
        },
        "c" : {
          "x" : 1156,
          "y" : 529
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1156,
          "y" : 529
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 38096,
    "reactomeId" : 11118532,
    "displayName" : "cAMP dissociates PKA, promoting GLI processing",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1222,
      "y" : 538
    },
    "minX" : 1200,
    "maxX" : 1273,
    "minY" : 532,
    "maxY" : 544,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1273,
        "y" : 540
      },
      "to" : {
        "x" : 1222,
        "y" : 538
      }
    }, {
      "from" : {
        "x" : 1222,
        "y" : 538
      },
      "to" : {
        "x" : 1200,
        "y" : 539
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1222,
        "y" : 538
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1222,
        "y" : 538
      }
    },
    "inputs" : [ {
      "id" : 38097,
      "points" : [ {
        "x" : 1309,
        "y" : 543
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 38098,
      "points" : [ {
        "x" : 1282,
        "y" : 520
      } ]
    } ],
    "outputs" : [ {
      "id" : 38099,
      "points" : [ {
        "x" : 1254,
        "y" : 744
      }, {
        "x" : 1149,
        "y" : 656
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 38100,
      "points" : [ {
        "x" : 1151,
        "y" : 523
      } ],
      "stoichiometry" : 2
    } ]
  } ],
  "compartments" : [ {
    "id" : 38128,
    "reactomeId" : 528865,
    "displayName" : "endocytic vesicle lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 222,
      "y" : 683
    },
    "minX" : 124,
    "maxX" : 320,
    "minY" : 614,
    "maxY" : 752,
    "prop" : {
      "x" : 124,
      "y" : 614,
      "width" : 196,
      "height" : 138
    },
    "textPosition" : {
      "x" : 144,
      "y" : 674
    },
    "insets" : {
      "x" : 134,
      "y" : 624,
      "width" : 176,
      "height" : 118
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 38129,
    "reactomeId" : 18730,
    "displayName" : "cilium",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1047,
      "y" : 234
    },
    "minX" : 620,
    "maxX" : 1475,
    "minY" : 0,
    "maxY" : 469,
    "prop" : {
      "x" : 620,
      "y" : 0,
      "width" : 855,
      "height" : 469
    },
    "textPosition" : {
      "x" : 1121,
      "y" : 340
    },
    "insets" : {
      "x" : 630,
      "y" : 10,
      "width" : 835,
      "height" : 449
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 38101,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1626,
      "y" : 951
    },
    "minX" : 0,
    "maxX" : 3253,
    "minY" : 443,
    "maxY" : 1460,
    "prop" : {
      "x" : 0,
      "y" : 443,
      "width" : 3253,
      "height" : 1017
    },
    "textPosition" : {
      "x" : 180,
      "y" : 512
    },
    "insets" : {
      "x" : 10,
      "y" : 453,
      "width" : 3233,
      "height" : 997
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 38110, 38099, 38097, 38096, 38098, 38100, 38128, 38130, 38131 ]
  }, {
    "id" : 38110,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2759,
      "y" : 749
    },
    "minX" : 2482,
    "maxX" : 3036,
    "minY" : 506,
    "maxY" : 993,
    "prop" : {
      "x" : 2482,
      "y" : 506,
      "width" : 554,
      "height" : 487
    },
    "textPosition" : {
      "x" : 2527,
      "y" : 547
    },
    "insets" : {
      "x" : 2492,
      "y" : 516,
      "width" : 534,
      "height" : 467
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 3253,
  "minY" : 0,
  "maxY" : 1460,
  "disease" : false
}