{ "dbId" : 11128424, "stableId" : "R-PFA-453276", "displayName" : "Regulation of mitotic cell cycle", "nodes" : [ { "id" : 47120, "reactomeId" : 11112014, "displayName" : "BTRC:CUL1:SKP1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 456, "y" : 918 }, "minX" : 405, "maxX" : 514, "minY" : 894, "maxY" : 984, "prop" : { "x" : 405, "y" : 900, "width" : 103, "height" : 36 }, "textPosition" : { "x" : 417, "y" : 901 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 508, "y" : 900 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 508, "y" : 900 } } }, "connectors" : [ { "edgeId" : 47118, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 456, "y" : 939 }, "to" : { "x" : 457, "y" : 984 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 460, "y" : 946 }, "b" : { "x" : 456, "y" : 939 }, "c" : { "x" : 452, "y" : 946 }, "type" : "ARROW", "centre" : { "x" : 452, "y" : 946 } } } ] }, { "id" : 47121, "reactomeId" : 11108984, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 556, "y" : 965 }, "minX" : 457, "maxX" : 597, "minY" : 954, "maxY" : 984, "prop" : { "x" : 516, "y" : 954, "width" : 81, "height" : 22 }, "textPosition" : { "x" : 544, "y" : 954 }, "connectors" : [ { "edgeId" : 47118, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 510, "y" : 972 }, "to" : { "x" : 457, "y" : 984 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 477, "y" : 972 }, "b" : { "x" : 489, "y" : 984 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 483, "y" : 978 } } }, "endShape" : { "a" : { "x" : 504, "y" : 977 }, "b" : { "x" : 510, "y" : 972 }, "c" : { "x" : 502, "y" : 970 }, "type" : "ARROW", "centre" : { "x" : 502, "y" : 970 } } } ] }, { "id" : 47122, "reactomeId" : 11109165, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 356, "y" : 1061 }, "minX" : 300, "maxX" : 419, "minY" : 992, "maxY" : 1072, "prop" : { "x" : 300, "y" : 1050, "width" : 113, "height" : 22 }, "textPosition" : { "x" : 300, "y" : 1051 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 413, "y" : 1050 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 413, "y" : 1050 } } }, "connectors" : [ { "edgeId" : 47118, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 356, "y" : 1047 }, "to" : { "x" : 357, "y" : 1000 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 357, "y" : 996 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 357, "y" : 996 } } } ] }, { "id" : 47142, "reactomeId" : 11112000, "displayName" : "FZR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 162, "y" : 1467 }, "minX" : 140, "maxX" : 190, "minY" : 1450, "maxY" : 1478, "prop" : { "x" : 140, "y" : 1456, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 142, "y" : 1456 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 184, "y" : 1456 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 184, "y" : 1456 } } }, "connectors" : [ ] }, { "id" : 47115, "reactomeId" : 11108984, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 673, "y" : 761 }, "minX" : 557, "maxX" : 710, "minY" : 750, "maxY" : 772, "prop" : { "x" : 637, "y" : 750, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 661, "y" : 750 }, "connectors" : [ { "edgeId" : 47114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 631, "y" : 760 }, "to" : { "x" : 557, "y" : 759 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 588, "y" : 753 }, "b" : { "x" : 600, "y" : 765 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 594, "y" : 759 } } } } ] }, { "id" : 47116, "reactomeId" : 11112018, "displayName" : "SCF-beta-TrCP:phospho-Emi1 complexes", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 555, "y" : 826 }, "minX" : 457, "maxX" : 612, "minY" : 759, "maxY" : 854, "prop" : { "x" : 505, "y" : 799, "width" : 101, "height" : 55 }, "textPosition" : { "x" : 505, "y" : 805 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 606, "y" : 799 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 606, "y" : 799 } } }, "connectors" : [ { "edgeId" : 47114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 555, "y" : 796 }, "to" : { "x" : 557, "y" : 759 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 47114, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 502, "y" : 818 }, "to" : { "x" : 466, "y" : 812 } }, { "from" : { "x" : 466, "y" : 812 }, "to" : { "x" : 461, "y" : 775 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 461, "y" : 771 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 461, "y" : 771 } } } ] }, { "id" : 47117, "reactomeId" : 11112020, "displayName" : "SCF-associated multiubiquitinated Emi1complexes", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 354, "y" : 760 }, "minX" : 291, "maxX" : 423, "minY" : 729, "maxY" : 785, "prop" : { "x" : 291, "y" : 735, "width" : 126, "height" : 50 }, "textPosition" : { "x" : 291, "y" : 736 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 417, "y" : 735 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 417, "y" : 735 } } }, "connectors" : [ { "edgeId" : 47114, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 47118, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 47119, "reactomeId" : 11112000, "displayName" : "FZR1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 409, "y" : 1347 }, "minX" : 362, "maxX" : 463, "minY" : 984, "maxY" : 1357, "prop" : { "x" : 362, "y" : 1338, "width" : 95, "height" : 19 }, "textPosition" : { "x" : 389, "y" : 1337 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 457, "y" : 1338 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 457, "y" : 1338 } } }, "connectors" : [ { "edgeId" : 47118, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 410, "y" : 1332 }, "to" : { "x" : 457, "y" : 984 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 407, "y" : 1325 }, "b" : { "x" : 410, "y" : 1332 }, "c" : { "x" : 415, "y" : 1326 }, "type" : "ARROW", "centre" : { "x" : 415, "y" : 1326 } } } ] } ], "edges" : [ { "id" : 47114, "reactomeId" : 11112023, "displayName" : "Ubiquitination of Emi1 by SCF-beta-TrCP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 459, "y" : 759 }, "minX" : 420, "maxX" : 557, "minY" : 753, "maxY" : 765, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 557, "y" : 759 }, "to" : { "x" : 459, "y" : 759 } }, { "from" : { "x" : 459, "y" : 759 }, "to" : { "x" : 420, "y" : 759 } } ], "endShape" : { "a" : { "x" : 427, "y" : 755 }, "b" : { "x" : 420, "y" : 759 }, "c" : { "x" : 427, "y" : 763 }, "type" : "ARROW", "centre" : { "x" : 427, "y" : 763 } }, "reactionShape" : { "a" : { "x" : 453, "y" : 753 }, "b" : { "x" : 465, "y" : 765 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 459, "y" : 759 } }, "inputs" : [ { "id" : 47115, "points" : [ { "x" : 631, "y" : 760 } ], "stoichiometry" : 3 }, { "id" : 47116, "points" : [ { "x" : 555, "y" : 796 } ] } ], "outputs" : [ { "id" : 47117 } ], "catalysts" : [ { "id" : 47116, "points" : [ { "x" : 502, "y" : 818 }, { "x" : 466, "y" : 812 } ] } ] }, { "id" : 47118, "reactomeId" : 11112025, "displayName" : "SCF-mediated degradation of Emi1", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 357, "y" : 984 }, "minX" : 351, "maxX" : 457, "minY" : 788, "maxY" : 990, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 354, "y" : 788 }, "to" : { "x" : 357, "y" : 984 } }, { "from" : { "x" : 357, "y" : 984 }, "to" : { "x" : 457, "y" : 984 } } ], "reactionShape" : { "a" : { "x" : 351, "y" : 978 }, "b" : { "x" : 363, "y" : 990 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 357, "y" : 984 } }, "inputs" : [ { "id" : 47117 } ], "outputs" : [ { "id" : 47119, "points" : [ { "x" : 410, "y" : 1332 } ] }, { "id" : 47120, "points" : [ { "x" : 456, "y" : 939 } ] }, { "id" : 47121, "points" : [ { "x" : 510, "y" : 972 } ], "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 47122, "points" : [ { "x" : 356, "y" : 1047 } ] } ] } ], "compartments" : [ { "id" : 47123, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 763, "y" : 377 }, "minX" : 30, "maxX" : 1497, "minY" : 44, "maxY" : 711, "prop" : { "x" : 30, "y" : 44, "width" : 1467, "height" : 667 }, "textPosition" : { "x" : 1330, "y" : 661 }, "insets" : { "x" : 40, "y" : 54, "width" : 1447, "height" : 647 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 47127, 47133, 47152, 47151 ] }, { "id" : 47124, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 770, "y" : 831 }, "minX" : 0, "maxX" : 1541, "minY" : 0, "maxY" : 1663, "prop" : { "x" : 0, "y" : 0, "width" : 1541, "height" : 1663 }, "textPosition" : { "x" : 1416, "y" : 1605 }, "insets" : { "x" : 10, "y" : 10, "width" : 1521, "height" : 1643 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 47123, 47142, 47120, 47116, 47114, 47115, 47117, 47118, 47119, 47122, 47154, 47155, 47156, 47153, 47121, 47157 ] } ], "notes" : [ ], "links" : [ { "id" : 47156, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 288, "y" : 1409 }, "minX" : 187, "maxX" : 389, "minY" : 1363, "maxY" : 1456, "segments" : [ { "from" : { "x" : 187, "y" : 1456 }, "to" : { "x" : 389, "y" : 1363 } } ], "reactionShape" : { "a" : { "x" : 282, "y" : 1403 }, "b" : { "x" : 294, "y" : 1415 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 288, "y" : 1409 } }, "inputs" : [ { "id" : 47142 } ], "outputs" : [ { "id" : 47119 } ] } ], "shadows" : [ { "id" : 47157, "reactomeId" : 11128422, "displayName" : "APC/C-mediated degradation of cell cycle proteins", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 500, "y" : 1046 }, "minX" : 281, "maxX" : 720, "minY" : 725, "maxY" : 1367, "prop" : { "x" : 281, "y" : 725, "width" : 439, "height" : 642 }, "points" : [ { "x" : 281, "y" : 725 }, { "x" : 720, "y" : 725 }, { "x" : 720, "y" : 1367 }, { "x" : 281, "y" : 1367 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 1541, "minY" : 0, "maxY" : 1663, "disease" : false }