{ "dbId" : 10101577, "stableId" : "R-MMU-8866654", "displayName" : "E3 ubiquitin ligases ubiquitinate target proteins", "nodes" : [ { "id" : 64449, "reactomeId" : 10081138, "displayName" : "Bcl10", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1570, "y" : 101 }, "minX" : 1458, "maxX" : 1645, "minY" : 83, "maxY" : 114, "prop" : { "x" : 1502, "y" : 89, "width" : 137, "height" : 25 }, "textPosition" : { "x" : 1549, "y" : 91 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1639, "y" : 89 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1639, "y" : 89 } } }, "connectors" : [ { "edgeId" : 64448, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1499, "y" : 93 }, "to" : { "x" : 1458, "y" : 88 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1492, "y" : 96 }, "b" : { "x" : 1499, "y" : 93 }, "c" : { "x" : 1493, "y" : 88 }, "type" : "ARROW", "centre" : { "x" : 1493, "y" : 88 } } } ] }, { "id" : 64450, "reactomeId" : 10081140, "displayName" : "UBE2D1,UBE2D2,UBE2D3,UBE2E1,UBE2N", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1512, "y" : 166 }, "minX" : 1421, "maxX" : 1603, "minY" : 88, "maxY" : 184, "prop" : { "x" : 1421, "y" : 148, "width" : 182, "height" : 36 }, "textPosition" : { "x" : 1427, "y" : 148 }, "connectors" : [ { "edgeId" : 64448, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1499, "y" : 142 }, "to" : { "x" : 1458, "y" : 88 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1472, "y" : 109 }, "b" : { "x" : 1484, "y" : 121 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1478, "y" : 115 } } }, "endShape" : { "a" : { "x" : 1492, "y" : 139 }, "b" : { "x" : 1499, "y" : 142 }, "c" : { "x" : 1498, "y" : 134 }, "type" : "ARROW", "centre" : { "x" : 1498, "y" : 134 } } } ] }, { "id" : 64452, "reactomeId" : 9992682, "displayName" : "PAF1C", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 257, "y" : 1412 }, "minX" : 227, "maxX" : 633, "minY" : 1351, "maxY" : 1423, "prop" : { "x" : 227, "y" : 1401, "width" : 60, "height" : 22 }, "textPosition" : { "x" : 233, "y" : 1402 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 287, "y" : 1401 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 287, "y" : 1401 } } }, "connectors" : [ { "edgeId" : 64451, "type" : "INPUT", "segments" : [ { "from" : { "x" : 272, "y" : 1398 }, "to" : { "x" : 344, "y" : 1351 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64458, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 290, "y" : 1411 }, "to" : { "x" : 600, "y" : 1411 } }, { "from" : { "x" : 600, "y" : 1411 }, "to" : { "x" : 633, "y" : 1352 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 297, "y" : 1407 }, "b" : { "x" : 290, "y" : 1411 }, "c" : { "x" : 297, "y" : 1415 }, "type" : "ARROW", "centre" : { "x" : 297, "y" : 1415 } } } ] }, { "id" : 64453, "reactomeId" : 10081862, "displayName" : "Wac", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 327, "y" : 1391 }, "minX" : 302, "maxX" : 633, "minY" : 1351, "maxY" : 1403, "prop" : { "x" : 302, "y" : 1379, "width" : 50, "height" : 24 }, "textPosition" : { "x" : 310, "y" : 1380 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 352, "y" : 1379 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 352, "y" : 1379 } } }, "connectors" : [ { "edgeId" : 64451, "type" : "INPUT", "segments" : [ { "from" : { "x" : 332, "y" : 1376 }, "to" : { "x" : 344, "y" : 1351 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64458, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 355, "y" : 1390 }, "to" : { "x" : 599, "y" : 1387 } }, { "from" : { "x" : 599, "y" : 1387 }, "to" : { "x" : 633, "y" : 1352 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 362, "y" : 1386 }, "b" : { "x" : 355, "y" : 1390 }, "c" : { "x" : 362, "y" : 1394 }, "type" : "ARROW", "centre" : { "x" : 362, "y" : 1394 } } } ] }, { "id" : 64454, "reactomeId" : 10081858, "displayName" : "RNF20:RNF40", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 201, "y" : 1289 }, "minX" : 148, "maxX" : 633, "minY" : 1270, "maxY" : 1352, "prop" : { "x" : 148, "y" : 1276, "width" : 107, "height" : 27 }, "textPosition" : { "x" : 155, "y" : 1282 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 255, "y" : 1276 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 255, "y" : 1276 } } }, "connectors" : [ { "edgeId" : 64451, "type" : "INPUT", "segments" : [ { "from" : { "x" : 232, "y" : 1306 }, "to" : { "x" : 344, "y" : 1351 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64458, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 258, "y" : 1288 }, "to" : { "x" : 618, "y" : 1288 } }, { "from" : { "x" : 618, "y" : 1288 }, "to" : { "x" : 633, "y" : 1352 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 265, "y" : 1284 }, "b" : { "x" : 258, "y" : 1288 }, "c" : { "x" : 265, "y" : 1292 }, "type" : "ARROW", "centre" : { "x" : 265, "y" : 1292 } } } ] }, { "id" : 64455, "reactomeId" : 10048484, "displayName" : "Histone HIST1H2B", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 235, "y" : 1351 }, "minX" : 165, "maxX" : 344, "minY" : 1339, "maxY" : 1363, "prop" : { "x" : 165, "y" : 1339, "width" : 141, "height" : 24 }, "textPosition" : { "x" : 175, "y" : 1340 }, "connectors" : [ { "edgeId" : 64451, "type" : "INPUT", "segments" : [ { "from" : { "x" : 312, "y" : 1351 }, "to" : { "x" : 344, "y" : 1351 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 64456, "reactomeId" : 10081866, "displayName" : "Ub:UBE2A,B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 335, "y" : 1307 }, "minX" : 287, "maxX" : 389, "minY" : 1289, "maxY" : 1351, "prop" : { "x" : 287, "y" : 1295, "width" : 96, "height" : 25 }, "textPosition" : { "x" : 294, "y" : 1299 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 383, "y" : 1295 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 383, "y" : 1295 } } }, "connectors" : [ { "edgeId" : 64451, "type" : "INPUT", "segments" : [ { "from" : { "x" : 337, "y" : 1323 }, "to" : { "x" : 344, "y" : 1351 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 64457, "reactomeId" : 10081868, "displayName" : "PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 485, "y" : 1349 }, "minX" : 397, "maxX" : 625, "minY" : 1326, "maxY" : 1366, "prop" : { "x" : 397, "y" : 1332, "width" : 177, "height" : 34 }, "textPosition" : { "x" : 401, "y" : 1331 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 574, "y" : 1332 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 574, "y" : 1332 } } }, "connectors" : [ { "edgeId" : 64451, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64458, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64458, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 577, "y" : 1353 }, "to" : { "x" : 617, "y" : 1355 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 621, "y" : 1355 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 621, "y" : 1355 } } } ] }, { "id" : 64459, "reactomeId" : 10081901, "displayName" : "Ub-histone HIST1H2B", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 717, "y" : 1381 }, "minX" : 633, "maxX" : 791, "minY" : 1352, "maxY" : 1393, "prop" : { "x" : 644, "y" : 1369, "width" : 147, "height" : 24 }, "textPosition" : { "x" : 647, "y" : 1370 }, "connectors" : [ { "edgeId" : 64458, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 682, "y" : 1363 }, "to" : { "x" : 633, "y" : 1352 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 674, "y" : 1365 }, "b" : { "x" : 682, "y" : 1363 }, "c" : { "x" : 676, "y" : 1358 }, "type" : "ARROW", "centre" : { "x" : 676, "y" : 1358 } } } ] }, { "id" : 64460, "reactomeId" : 10081903, "displayName" : "UBE2A,B", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 703, "y" : 1329 }, "minX" : 633, "maxX" : 742, "minY" : 1317, "maxY" : 1352, "prop" : { "x" : 664, "y" : 1317, "width" : 78, "height" : 25 }, "textPosition" : { "x" : 672, "y" : 1319 }, "connectors" : [ { "edgeId" : 64458, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 658, "y" : 1341 }, "to" : { "x" : 633, "y" : 1352 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 653, "y" : 1347 }, "b" : { "x" : 658, "y" : 1341 }, "c" : { "x" : 650, "y" : 1340 }, "type" : "ARROW", "centre" : { "x" : 650, "y" : 1340 } } } ] }, { "id" : 64462, "reactomeId" : 10057724, "displayName" : "RAD18:UBE2B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 854, "y" : 1062 }, "minX" : 792, "maxX" : 1380, "minY" : 1044, "maxY" : 1154, "prop" : { "x" : 803, "y" : 1050, "width" : 103, "height" : 25 }, "textPosition" : { "x" : 807, "y" : 1054 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 906, "y" : 1050 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 906, "y" : 1050 } } }, "connectors" : [ { "edgeId" : 64461, "type" : "INPUT", "segments" : [ { "from" : { "x" : 909, "y" : 1060 }, "to" : { "x" : 1000, "y" : 1057 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64467, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 823, "y" : 1078 }, "to" : { "x" : 792, "y" : 1087 } }, { "from" : { "x" : 792, "y" : 1087 }, "to" : { "x" : 793, "y" : 1152 } }, { "from" : { "x" : 793, "y" : 1152 }, "to" : { "x" : 1380, "y" : 1154 } }, { "from" : { "x" : 1380, "y" : 1154 }, "to" : { "x" : 1380, "y" : 1107 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 817, "y" : 1084 }, "b" : { "x" : 823, "y" : 1078 }, "c" : { "x" : 815, "y" : 1076 }, "type" : "ARROW", "centre" : { "x" : 815, "y" : 1076 } } } ] }, { "id" : 64463, "reactomeId" : 10082014, "displayName" : "Ub:UBE2N:UBE2V2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 966, "y" : 1106 }, "minX" : 899, "maxX" : 1233, "minY" : 1057, "maxY" : 1119, "prop" : { "x" : 899, "y" : 1093, "width" : 134, "height" : 26 }, "textPosition" : { "x" : 904, "y" : 1098 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1033, "y" : 1093 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1033, "y" : 1093 } } }, "connectors" : [ { "edgeId" : 64461, "type" : "INPUT", "segments" : [ { "from" : { "x" : 975, "y" : 1090 }, "to" : { "x" : 1000, "y" : 1057 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64467, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1036, "y" : 1106 }, "to" : { "x" : 1233, "y" : 1108 } } ], "stoichiometry" : { "value" : 8, "shape" : { "a" : { "x" : 1128, "y" : 1101 }, "b" : { "x" : 1140, "y" : 1113 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1134, "y" : 1107 } } } } ] }, { "id" : 64464, "reactomeId" : 10082008, "displayName" : "SHPRH", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 837, "y" : 1102 }, "minX" : 807, "maxX" : 1380, "minY" : 1057, "maxY" : 1147, "prop" : { "x" : 807, "y" : 1091, "width" : 61, "height" : 23 }, "textPosition" : { "x" : 812, "y" : 1092 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 868, "y" : 1091 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 868, "y" : 1091 } } }, "connectors" : [ { "edgeId" : 64461, "type" : "INPUT", "segments" : [ { "from" : { "x" : 871, "y" : 1093 }, "to" : { "x" : 1000, "y" : 1057 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64467, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 845, "y" : 1117 }, "to" : { "x" : 868, "y" : 1144 } }, { "from" : { "x" : 868, "y" : 1144 }, "to" : { "x" : 1366, "y" : 1147 } }, { "from" : { "x" : 1366, "y" : 1147 }, "to" : { "x" : 1380, "y" : 1107 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 853, "y" : 1120 }, "b" : { "x" : 845, "y" : 1117 }, "c" : { "x" : 846, "y" : 1125 }, "type" : "ARROW", "centre" : { "x" : 846, "y" : 1125 } } } ] }, { "id" : 64465, "reactomeId" : 9991961, "displayName" : "MonoUb:K164-PCNA homotrimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 909, "y" : 1031 }, "minX" : 789, "maxX" : 1035, "minY" : 1000, "maxY" : 1057, "prop" : { "x" : 789, "y" : 1021, "width" : 240, "height" : 21 }, "textPosition" : { "x" : 805, "y" : 1021 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1029, "y" : 1021 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1029, "y" : 1021 } } }, "connectors" : [ { "edgeId" : 64461, "type" : "INPUT", "segments" : [ { "from" : { "x" : 945, "y" : 1045 }, "to" : { "x" : 1000, "y" : 1057 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64470, "type" : "INPUT", "segments" : [ { "from" : { "x" : 936, "y" : 1018 }, "to" : { "x" : 990, "y" : 1000 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 64466, "reactomeId" : 10082016, "displayName" : "SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1202, "y" : 1056 }, "minX" : 1085, "maxX" : 1326, "minY" : 1033, "maxY" : 1108, "prop" : { "x" : 1085, "y" : 1039, "width" : 235, "height" : 34 }, "textPosition" : { "x" : 1089, "y" : 1038 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1320, "y" : 1039 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1320, "y" : 1039 } } }, "connectors" : [ { "edgeId" : 64461, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64467, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1212, "y" : 1076 }, "to" : { "x" : 1233, "y" : 1108 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64467, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1224, "y" : 1076 }, "to" : { "x" : 1257, "y" : 1098 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1260, "y" : 1100 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1260, "y" : 1100 } } } ] }, { "id" : 64468, "reactomeId" : 9985983, "displayName" : "UBE2N:UBE2V2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1478, "y" : 1136 }, "minX" : 1380, "maxX" : 1549, "minY" : 1107, "maxY" : 1148, "prop" : { "x" : 1414, "y" : 1124, "width" : 129, "height" : 24 }, "textPosition" : { "x" : 1427, "y" : 1127 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1543, "y" : 1124 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1543, "y" : 1124 } } }, "connectors" : [ { "edgeId" : 64467, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1437, "y" : 1121 }, "to" : { "x" : 1380, "y" : 1107 } } ], "stoichiometry" : { "value" : 9, "shape" : { "a" : { "x" : 1402, "y" : 1108 }, "b" : { "x" : 1414, "y" : 1120 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1408, "y" : 1114 } } }, "endShape" : { "a" : { "x" : 1429, "y" : 1123 }, "b" : { "x" : 1437, "y" : 1121 }, "c" : { "x" : 1431, "y" : 1115 }, "type" : "ARROW", "centre" : { "x" : 1431, "y" : 1115 } } } ] }, { "id" : 64469, "reactomeId" : 10082021, "displayName" : "K63polyUb-K164-PCNA homotrimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1457, "y" : 1041 }, "minX" : 1375, "maxX" : 1529, "minY" : 959, "maxY" : 1107, "prop" : { "x" : 1392, "y" : 1022, "width" : 131, "height" : 38 }, "textPosition" : { "x" : 1399, "y" : 1025 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1523, "y" : 1022 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1523, "y" : 1022 } } }, "connectors" : [ { "edgeId" : 64467, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1434, "y" : 1063 }, "to" : { "x" : 1380, "y" : 1107 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1431, "y" : 1070 }, "b" : { "x" : 1434, "y" : 1063 }, "c" : { "x" : 1426, "y" : 1064 }, "type" : "ARROW", "centre" : { "x" : 1426, "y" : 1064 } } }, { "edgeId" : 64475, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1438, "y" : 1019 }, "to" : { "x" : 1375, "y" : 959 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1430, "y" : 1017 }, "b" : { "x" : 1438, "y" : 1019 }, "c" : { "x" : 1436, "y" : 1011 }, "type" : "ARROW", "centre" : { "x" : 1436, "y" : 1011 } } } ] }, { "id" : 64471, "reactomeId" : 10082030, "displayName" : "HLTF", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 852, "y" : 966 }, "minX" : 826, "maxX" : 1375, "minY" : 924, "maxY" : 1000, "prop" : { "x" : 826, "y" : 955, "width" : 53, "height" : 22 }, "textPosition" : { "x" : 834, "y" : 955 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 879, "y" : 955 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 879, "y" : 955 } } }, "connectors" : [ { "edgeId" : 64470, "type" : "INPUT", "segments" : [ { "from" : { "x" : 882, "y" : 972 }, "to" : { "x" : 990, "y" : 1000 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64475, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 852, "y" : 952 }, "to" : { "x" : 855, "y" : 924 } }, { "from" : { "x" : 855, "y" : 924 }, "to" : { "x" : 1363, "y" : 929 } }, { "from" : { "x" : 1363, "y" : 929 }, "to" : { "x" : 1375, "y" : 959 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 849, "y" : 945 }, "b" : { "x" : 852, "y" : 952 }, "c" : { "x" : 857, "y" : 946 }, "type" : "ARROW", "centre" : { "x" : 857, "y" : 946 } } } ] }, { "id" : 64472, "reactomeId" : 10082014, "displayName" : "Ub:UBE2N:UBE2V2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 962, "y" : 958 }, "minX" : 893, "maxX" : 1224, "minY" : 940, "maxY" : 1000, "prop" : { "x" : 893, "y" : 946, "width" : 139, "height" : 24 }, "textPosition" : { "x" : 900, "y" : 949 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1032, "y" : 946 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1032, "y" : 946 } } }, "connectors" : [ { "edgeId" : 64470, "type" : "INPUT", "segments" : [ { "from" : { "x" : 970, "y" : 973 }, "to" : { "x" : 990, "y" : 1000 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64475, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1035, "y" : 958 }, "to" : { "x" : 1224, "y" : 958 } } ], "stoichiometry" : { "value" : 8, "shape" : { "a" : { "x" : 1123, "y" : 952 }, "b" : { "x" : 1135, "y" : 964 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1129, "y" : 958 } } } } ] }, { "id" : 64473, "reactomeId" : 10057724, "displayName" : "RAD18:UBE2B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 857, "y" : 998 }, "minX" : 784, "maxX" : 1375, "minY" : 911, "maxY" : 1008, "prop" : { "x" : 803, "y" : 988, "width" : 109, "height" : 20 }, "textPosition" : { "x" : 810, "y" : 987 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 912, "y" : 988 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 912, "y" : 988 } } }, "connectors" : [ { "edgeId" : 64470, "type" : "INPUT", "segments" : [ { "from" : { "x" : 915, "y" : 998 }, "to" : { "x" : 990, "y" : 1000 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64475, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 816, "y" : 985 }, "to" : { "x" : 788, "y" : 981 } }, { "from" : { "x" : 788, "y" : 981 }, "to" : { "x" : 784, "y" : 911 } }, { "from" : { "x" : 784, "y" : 911 }, "to" : { "x" : 1368, "y" : 916 } }, { "from" : { "x" : 1368, "y" : 916 }, "to" : { "x" : 1375, "y" : 959 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 809, "y" : 988 }, "b" : { "x" : 816, "y" : 985 }, "c" : { "x" : 810, "y" : 980 }, "type" : "ARROW", "centre" : { "x" : 810, "y" : 980 } } } ] }, { "id" : 64474, "reactomeId" : 10082032, "displayName" : "HLTF:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1198, "y" : 1001 }, "minX" : 1083, "maxX" : 1319, "minY" : 958, "maxY" : 1017, "prop" : { "x" : 1083, "y" : 986, "width" : 230, "height" : 31 }, "textPosition" : { "x" : 1091, "y" : 982 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1313, "y" : 986 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1313, "y" : 986 } } }, "connectors" : [ { "edgeId" : 64470, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64475, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1207, "y" : 983 }, "to" : { "x" : 1224, "y" : 958 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64475, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1225, "y" : 983 }, "to" : { "x" : 1263, "y" : 964 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1266, "y" : 962 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1266, "y" : 962 } } } ] }, { "id" : 64476, "reactomeId" : 9985983, "displayName" : "UBE2N:UBE2V2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1481, "y" : 939 }, "minX" : 1375, "maxX" : 1545, "minY" : 921, "maxY" : 960, "prop" : { "x" : 1424, "y" : 927, "width" : 115, "height" : 24 }, "textPosition" : { "x" : 1430, "y" : 930 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1539, "y" : 927 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1539, "y" : 927 } } }, "connectors" : [ { "edgeId" : 64475, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1421, "y" : 949 }, "to" : { "x" : 1375, "y" : 959 } } ], "stoichiometry" : { "value" : 9, "shape" : { "a" : { "x" : 1392, "y" : 948 }, "b" : { "x" : 1404, "y" : 960 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1398, "y" : 954 } } }, "endShape" : { "a" : { "x" : 1415, "y" : 954 }, "b" : { "x" : 1421, "y" : 949 }, "c" : { "x" : 1413, "y" : 947 }, "type" : "ARROW", "centre" : { "x" : 1413, "y" : 947 } } } ] }, { "id" : 64478, "reactomeId" : 10083921, "displayName" : "PEX2:PEX10:PEX12:PEX5S,L:Ub:UBE2D1,2,3:PEX13:PEX14", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1166, "y" : 769 }, "minX" : 1094, "maxX" : 1279, "minY" : 737, "maxY" : 795, "prop" : { "x" : 1094, "y" : 743, "width" : 144, "height" : 52 }, "textPosition" : { "x" : 1098, "y" : 746 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1238, "y" : 743 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1238, "y" : 743 } } }, "connectors" : [ { "edgeId" : 64481, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64477, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64477, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1241, "y" : 763 }, "to" : { "x" : 1271, "y" : 760 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1275, "y" : 760 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1275, "y" : 760 } } } ] }, { "id" : 64479, "reactomeId" : 9997033, "displayName" : "UBE2D1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1402, "y" : 831 }, "minX" : 1352, "maxX" : 1452, "minY" : 758, "maxY" : 844, "prop" : { "x" : 1352, "y" : 819, "width" : 100, "height" : 25 }, "textPosition" : { "x" : 1361, "y" : 821 }, "connectors" : [ { "edgeId" : 64477, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1395, "y" : 813 }, "to" : { "x" : 1366, "y" : 758 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1388, "y" : 809 }, "b" : { "x" : 1395, "y" : 813 }, "c" : { "x" : 1395, "y" : 805 }, "type" : "ARROW", "centre" : { "x" : 1395, "y" : 805 } } } ] }, { "id" : 64480, "reactomeId" : 10083930, "displayName" : "PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1482, "y" : 737 }, "minX" : 1366, "maxX" : 1559, "minY" : 705, "maxY" : 763, "prop" : { "x" : 1411, "y" : 711, "width" : 142, "height" : 52 }, "textPosition" : { "x" : 1417, "y" : 714 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1553, "y" : 711 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1553, "y" : 711 } } }, "connectors" : [ { "edgeId" : 64477, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1408, "y" : 749 }, "to" : { "x" : 1366, "y" : 758 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1402, "y" : 754 }, "b" : { "x" : 1408, "y" : 749 }, "c" : { "x" : 1400, "y" : 747 }, "type" : "ARROW", "centre" : { "x" : 1400, "y" : 747 } } } ] }, { "id" : 64482, "reactomeId" : 10083915, "displayName" : "PEX5S,L:PEX13:PEX14:PEX2:PEX10:PEX12", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 976, "y" : 706 }, "minX" : 916, "maxX" : 1043, "minY" : 675, "maxY" : 767, "prop" : { "x" : 916, "y" : 681, "width" : 121, "height" : 50 }, "textPosition" : { "x" : 924, "y" : 682 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1037, "y" : 681 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1037, "y" : 681 } } }, "connectors" : [ { "edgeId" : 64481, "type" : "INPUT", "segments" : [ { "from" : { "x" : 978, "y" : 734 }, "to" : { "x" : 983, "y" : 767 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 64483, "reactomeId" : 10083919, "displayName" : "Ub:UBE2D1,2,3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 928, "y" : 829 }, "minX" : 868, "maxX" : 995, "minY" : 767, "maxY" : 843, "prop" : { "x" : 868, "y" : 815, "width" : 121, "height" : 28 }, "textPosition" : { "x" : 877, "y" : 822 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 989, "y" : 815 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 989, "y" : 815 } } }, "connectors" : [ { "edgeId" : 64481, "type" : "INPUT", "segments" : [ { "from" : { "x" : 940, "y" : 812 }, "to" : { "x" : 983, "y" : 767 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 64428, "reactomeId" : 10080995, "displayName" : "Ub:UBE2L3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 257, "y" : 408 }, "minX" : 207, "maxX" : 616, "minY" : 376, "maxY" : 418, "prop" : { "x" : 207, "y" : 398, "width" : 101, "height" : 20 }, "textPosition" : { "x" : 219, "y" : 397 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 308, "y" : 398 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 308, "y" : 398 } } }, "connectors" : [ { "edgeId" : 64427, "type" : "INPUT", "segments" : [ { "from" : { "x" : 272, "y" : 395 }, "to" : { "x" : 298, "y" : 381 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64432, "type" : "INPUT", "segments" : [ { "from" : { "x" : 311, "y" : 407 }, "to" : { "x" : 579, "y" : 403 } }, { "from" : { "x" : 579, "y" : 403 }, "to" : { "x" : 616, "y" : 376 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 439, "y" : 399 }, "b" : { "x" : 451, "y" : 411 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 445, "y" : 405 } } } } ] }, { "id" : 64429, "reactomeId" : 10080993, "displayName" : "RNF144A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 120, "y" : 363 }, "minX" : 77, "maxX" : 689, "minY" : 328, "maxY" : 381, "prop" : { "x" : 77, "y" : 353, "width" : 86, "height" : 21 }, "textPosition" : { "x" : 88, "y" : 353 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 163, "y" : 353 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 163, "y" : 353 } } }, "connectors" : [ { "edgeId" : 64427, "type" : "INPUT", "segments" : [ { "from" : { "x" : 166, "y" : 367 }, "to" : { "x" : 298, "y" : 381 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64432, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 142, "y" : 350 }, "to" : { "x" : 195, "y" : 328 } }, { "from" : { "x" : 195, "y" : 328 }, "to" : { "x" : 674, "y" : 332 } }, { "from" : { "x" : 674, "y" : 332 }, "to" : { "x" : 689, "y" : 373 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 147, "y" : 344 }, "b" : { "x" : 142, "y" : 350 }, "c" : { "x" : 150, "y" : 351 }, "type" : "ARROW", "centre" : { "x" : 150, "y" : 351 } } } ] }, { "id" : 64430, "reactomeId" : 10080989, "displayName" : "Prkdc", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 148, "y" : 399 }, "minX" : 117, "maxX" : 298, "minY" : 381, "maxY" : 412, "prop" : { "x" : 117, "y" : 387, "width" : 63, "height" : 25 }, "textPosition" : { "x" : 127, "y" : 389 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 180, "y" : 387 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 180, "y" : 387 } } }, "connectors" : [ { "edgeId" : 64427, "type" : "INPUT", "segments" : [ { "from" : { "x" : 183, "y" : 395 }, "to" : { "x" : 298, "y" : 381 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 64431, "reactomeId" : 10080997, "displayName" : "RNF144A:PRKDC:Ub:UBE2L3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 467, "y" : 376 }, "minX" : 405, "maxX" : 641, "minY" : 352, "maxY" : 394, "prop" : { "x" : 405, "y" : 358, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 411, "y" : 359 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 530, "y" : 358 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 530, "y" : 358 } } }, "connectors" : [ { "edgeId" : 64427, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64432, "type" : "INPUT", "segments" : [ { "from" : { "x" : 533, "y" : 376 }, "to" : { "x" : 616, "y" : 376 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64432, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 533, "y" : 374 }, "to" : { "x" : 633, "y" : 371 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 637, "y" : 371 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 637, "y" : 371 } } } ] }, { "id" : 64433, "reactomeId" : 10026876, "displayName" : "Ube2l3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 739, "y" : 318 }, "minX" : 689, "maxX" : 778, "minY" : 300, "maxY" : 373, "prop" : { "x" : 706, "y" : 306, "width" : 66, "height" : 24 }, "textPosition" : { "x" : 713, "y" : 307 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 772, "y" : 306 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 772, "y" : 306 } } }, "connectors" : [ { "edgeId" : 64432, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 728, "y" : 333 }, "to" : { "x" : 689, "y" : 373 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 702, "y" : 347 }, "b" : { "x" : 714, "y" : 359 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 708, "y" : 353 } } }, "endShape" : { "a" : { "x" : 726, "y" : 341 }, "b" : { "x" : 728, "y" : 333 }, "c" : { "x" : 720, "y" : 335 }, "type" : "ARROW", "centre" : { "x" : 720, "y" : 335 } } } ] }, { "id" : 64434, "reactomeId" : 10081002, "displayName" : "Prkdc", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 795, "y" : 372 }, "minX" : 689, "maxX" : 868, "minY" : 353, "maxY" : 385, "prop" : { "x" : 728, "y" : 359, "width" : 134, "height" : 26 }, "textPosition" : { "x" : 773, "y" : 361 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 862, "y" : 359 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 862, "y" : 359 } } }, "connectors" : [ { "edgeId" : 64432, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 725, "y" : 372 }, "to" : { "x" : 689, "y" : 373 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 718, "y" : 376 }, "b" : { "x" : 725, "y" : 372 }, "c" : { "x" : 718, "y" : 368 }, "type" : "ARROW", "centre" : { "x" : 718, "y" : 368 } } } ] }, { "id" : 64436, "reactomeId" : 10081011, "displayName" : "RRAGA:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 983, "y" : 570 }, "minX" : 932, "maxX" : 1067, "minY" : 550, "maxY" : 584, "prop" : { "x" : 932, "y" : 556, "width" : 102, "height" : 28 }, "textPosition" : { "x" : 943, "y" : 563 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1034, "y" : 556 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1034, "y" : 556 } } }, "connectors" : [ { "edgeId" : 64435, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1037, "y" : 563 }, "to" : { "x" : 1067, "y" : 559 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 64437, "reactomeId" : 10081009, "displayName" : "Rnf152", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 999, "y" : 499 }, "minX" : 959, "maxX" : 1384, "minY" : 479, "maxY" : 559, "prop" : { "x" : 959, "y" : 485, "width" : 81, "height" : 28 }, "textPosition" : { "x" : 973, "y" : 488 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1040, "y" : 485 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1040, "y" : 485 } } }, "connectors" : [ { "edgeId" : 64435, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1014, "y" : 516 }, "to" : { "x" : 1067, "y" : 559 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64440, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1043, "y" : 498 }, "to" : { "x" : 1384, "y" : 498 } }, { "from" : { "x" : 1384, "y" : 498 }, "to" : { "x" : 1382, "y" : 552 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1050, "y" : 494 }, "b" : { "x" : 1043, "y" : 498 }, "c" : { "x" : 1050, "y" : 502 }, "type" : "ARROW", "centre" : { "x" : 1050, "y" : 502 } } } ] }, { "id" : 64438, "reactomeId" : 10081016, "displayName" : "Ub:UBE2N", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1053, "y" : 606 }, "minX" : 1017, "maxX" : 1317, "minY" : 559, "maxY" : 617, "prop" : { "x" : 1017, "y" : 595, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 1017, "y" : 596 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1089, "y" : 595 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1089, "y" : 595 } } }, "connectors" : [ { "edgeId" : 64435, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1056, "y" : 592 }, "to" : { "x" : 1067, "y" : 559 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64440, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1092, "y" : 605 }, "to" : { "x" : 1299, "y" : 603 } }, { "from" : { "x" : 1299, "y" : 603 }, "to" : { "x" : 1317, "y" : 564 } } ], "stoichiometry" : { "value" : 11, "shape" : { "a" : { "x" : 1189, "y" : 598 }, "b" : { "x" : 1201, "y" : 610 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1195, "y" : 604 } } } } ] }, { "id" : 64439, "reactomeId" : 10081018, "displayName" : "RNF152:RRAGA:GDP:Ub:UBE2N", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1216, "y" : 527 }, "minX" : 1143, "maxX" : 1331, "minY" : 504, "maxY" : 564, "prop" : { "x" : 1143, "y" : 510, "width" : 146, "height" : 34 }, "textPosition" : { "x" : 1148, "y" : 509 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1289, "y" : 510 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1289, "y" : 510 } } }, "connectors" : [ { "edgeId" : 64435, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64440, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1262, "y" : 547 }, "to" : { "x" : 1317, "y" : 564 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64440, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1292, "y" : 541 }, "to" : { "x" : 1323, "y" : 548 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1327, "y" : 549 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1327, "y" : 549 } } } ] }, { "id" : 64441, "reactomeId" : 10081026, "displayName" : "K63polyUb-K142,K220,K230,K244-RRAGA:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1430, "y" : 596 }, "minX" : 1348, "maxX" : 1519, "minY" : 552, "maxY" : 612, "prop" : { "x" : 1348, "y" : 580, "width" : 165, "height" : 32 }, "textPosition" : { "x" : 1356, "y" : 577 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1513, "y" : 580 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1513, "y" : 580 } } }, "connectors" : [ { "edgeId" : 64440, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1412, "y" : 577 }, "to" : { "x" : 1382, "y" : 552 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1404, "y" : 576 }, "b" : { "x" : 1412, "y" : 577 }, "c" : { "x" : 1409, "y" : 569 }, "type" : "ARROW", "centre" : { "x" : 1409, "y" : 569 } } } ] }, { "id" : 64442, "reactomeId" : 9997041, "displayName" : "Ube2n", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1477, "y" : 556 }, "minX" : 1382, "maxX" : 1509, "minY" : 539, "maxY" : 567, "prop" : { "x" : 1452, "y" : 545, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 1453, "y" : 545 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1503, "y" : 545 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1503, "y" : 545 } } }, "connectors" : [ { "edgeId" : 64440, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1449, "y" : 554 }, "to" : { "x" : 1382, "y" : 552 } } ], "stoichiometry" : { "value" : 12, "shape" : { "a" : { "x" : 1409, "y" : 547 }, "b" : { "x" : 1421, "y" : 559 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1415, "y" : 553 } } }, "endShape" : { "a" : { "x" : 1442, "y" : 558 }, "b" : { "x" : 1449, "y" : 554 }, "c" : { "x" : 1442, "y" : 550 }, "type" : "ARROW", "centre" : { "x" : 1442, "y" : 550 } } } ] }, { "id" : 64444, "reactomeId" : 2685587, "displayName" : "Bcl10", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1008, "y" : 101 }, "minX" : 978, "maxX" : 1066, "minY" : 83, "maxY" : 114, "prop" : { "x" : 978, "y" : 89, "width" : 61, "height" : 25 }, "textPosition" : { "x" : 987, "y" : 91 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1039, "y" : 89 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1039, "y" : 89 } } }, "connectors" : [ { "edgeId" : 64443, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1042, "y" : 93 }, "to" : { "x" : 1066, "y" : 87 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 64445, "reactomeId" : 10081122, "displayName" : "Rnf181", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 983, "y" : 61 }, "minX" : 955, "maxX" : 1458, "minY" : 44, "maxY" : 88, "prop" : { "x" : 955, "y" : 50, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 957, "y" : 50 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1012, "y" : 50 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1012, "y" : 50 } } }, "connectors" : [ { "edgeId" : 64448, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1015, "y" : 61 }, "to" : { "x" : 1456, "y" : 61 } }, { "from" : { "x" : 1456, "y" : 61 }, "to" : { "x" : 1458, "y" : 88 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1022, "y" : 57 }, "b" : { "x" : 1015, "y" : 61 }, "c" : { "x" : 1022, "y" : 65 }, "type" : "ARROW", "centre" : { "x" : 1022, "y" : 65 } } }, { "edgeId" : 64443, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1015, "y" : 69 }, "to" : { "x" : 1066, "y" : 87 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 64446, "reactomeId" : 10081131, "displayName" : "Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1054, "y" : 143 }, "minX" : 965, "maxX" : 1376, "minY" : 87, "maxY" : 163, "prop" : { "x" : 965, "y" : 124, "width" : 178, "height" : 39 }, "textPosition" : { "x" : 973, "y" : 128 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1143, "y" : 124 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1143, "y" : 124 } } }, "connectors" : [ { "edgeId" : 64448, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1146, "y" : 130 }, "to" : { "x" : 1376, "y" : 97 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1255, "y" : 107 }, "b" : { "x" : 1267, "y" : 119 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1261, "y" : 113 } } } }, { "edgeId" : 64443, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1058, "y" : 121 }, "to" : { "x" : 1066, "y" : 87 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 64447, "reactomeId" : 10081133, "displayName" : "RNF181:BCL10:Ub:E2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1230, "y" : 88 }, "minX" : 1133, "maxX" : 1407, "minY" : 71, "maxY" : 117, "prop" : { "x" : 1133, "y" : 77, "width" : 195, "height" : 23 }, "textPosition" : { "x" : 1161, "y" : 79 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1328, "y" : 77 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1328, "y" : 77 } } }, "connectors" : [ { "edgeId" : 64448, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1276, "y" : 103 }, "to" : { "x" : 1346, "y" : 117 } }, { "from" : { "x" : 1346, "y" : 117 }, "to" : { "x" : 1376, "y" : 97 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 64448, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1331, "y" : 88 }, "to" : { "x" : 1399, "y" : 88 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1403, "y" : 88 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1403, "y" : 88 } } }, { "edgeId" : 64443, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 64448, "reactomeId" : 10081143, "displayName" : "RNF181 polyubiquinates BCL10", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1415, "y" : 88 }, "minX" : 1376, "maxX" : 1458, "minY" : 82, "maxY" : 97, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1376, "y" : 97 }, "to" : { "x" : 1415, "y" : 88 } }, { "from" : { "x" : 1415, "y" : 88 }, "to" : { "x" : 1458, "y" : 88 } } ], "reactionShape" : { "a" : { "x" : 1409, "y" : 82 }, "b" : { "x" : 1421, "y" : 94 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1415, "y" : 88 } }, "inputs" : [ { "id" : 64447, "points" : [ { "x" : 1276, "y" : 103 }, { "x" : 1346, "y" : 117 } ] }, { "id" : 64446, "points" : [ { "x" : 1146, "y" : 130 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 64449, "points" : [ { "x" : 1499, "y" : 93 } ] }, { "id" : 64445, "points" : [ { "x" : 1015, "y" : 61 }, { "x" : 1456, "y" : 61 } ] }, { "id" : 64450, "points" : [ { "x" : 1499, "y" : 142 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 64447, "points" : [ { "x" : 1331, "y" : 88 } ] } ] }, { "id" : 64481, "reactomeId" : 10083923, "displayName" : "PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1037, "y" : 766 }, "minX" : 983, "maxX" : 1091, "minY" : 760, "maxY" : 772, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 983, "y" : 767 }, "to" : { "x" : 1037, "y" : 766 } }, { "from" : { "x" : 1037, "y" : 766 }, "to" : { "x" : 1091, "y" : 767 } } ], "endShape" : { "a" : { "x" : 1084, "y" : 771 }, "b" : { "x" : 1091, "y" : 767 }, "c" : { "x" : 1084, "y" : 763 }, "type" : "ARROW", "centre" : { "x" : 1084, "y" : 763 } }, "reactionShape" : { "c" : { "x" : 1037, "y" : 766 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1037, "y" : 766 } }, "inputs" : [ { "id" : 64482, "points" : [ { "x" : 978, "y" : 734 } ] }, { "id" : 64483, "points" : [ { "x" : 940, "y" : 812 } ] } ], "outputs" : [ { "id" : 64478 } ] }, { "id" : 64451, "reactomeId" : 10081870, "displayName" : "RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 369, "y" : 1349 }, "minX" : 344, "maxX" : 394, "minY" : 1343, "maxY" : 1355, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 344, "y" : 1351 }, "to" : { "x" : 369, "y" : 1349 } }, { "from" : { "x" : 369, "y" : 1349 }, "to" : { "x" : 394, "y" : 1349 } } ], "endShape" : { "a" : { "x" : 387, "y" : 1353 }, "b" : { "x" : 394, "y" : 1349 }, "c" : { "x" : 387, "y" : 1345 }, "type" : "ARROW", "centre" : { "x" : 387, "y" : 1345 } }, "reactionShape" : { "c" : { "x" : 369, "y" : 1349 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 369, "y" : 1349 } }, "inputs" : [ { "id" : 64452, "points" : [ { "x" : 272, "y" : 1398 } ] }, { "id" : 64453, "points" : [ { "x" : 332, "y" : 1376 } ] }, { "id" : 64454, "points" : [ { "x" : 232, "y" : 1306 } ] }, { "id" : 64455, "points" : [ { "x" : 312, "y" : 1351 } ] }, { "id" : 64456, "points" : [ { "x" : 337, "y" : 1323 } ] } ], "outputs" : [ { "id" : 64457 } ] }, { "id" : 64458, "reactomeId" : 10081906, "displayName" : "RNF20:RNF40 monoubiquitinates Histone H2B", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 633, "y" : 1356 }, "minX" : 577, "maxX" : 639, "minY" : 1346, "maxY" : 1362, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 577, "y" : 1346 }, "to" : { "x" : 633, "y" : 1356 } }, { "from" : { "x" : 633, "y" : 1356 }, "to" : { "x" : 633, "y" : 1352 } } ], "reactionShape" : { "a" : { "x" : 627, "y" : 1350 }, "b" : { "x" : 639, "y" : 1362 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 633, "y" : 1356 } }, "inputs" : [ { "id" : 64457 } ], "outputs" : [ { "id" : 64459, "points" : [ { "x" : 682, "y" : 1363 } ] }, { "id" : 64460, "points" : [ { "x" : 658, "y" : 1341 } ] }, { "id" : 64452, "points" : [ { "x" : 290, "y" : 1411 }, { "x" : 600, "y" : 1411 } ] }, { "id" : 64453, "points" : [ { "x" : 355, "y" : 1390 }, { "x" : 599, "y" : 1387 } ] }, { "id" : 64454, "points" : [ { "x" : 258, "y" : 1288 }, { "x" : 618, "y" : 1288 } ] } ], "catalysts" : [ { "id" : 64457, "points" : [ { "x" : 577, "y" : 1353 } ] } ] }, { "id" : 64427, "reactomeId" : 10080999, "displayName" : "RNF144A binds PRKDC and Ubiquitin:UBE2L3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 324, "y" : 380 }, "minX" : 298, "maxX" : 402, "minY" : 374, "maxY" : 386, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 298, "y" : 381 }, "to" : { "x" : 324, "y" : 380 } }, { "from" : { "x" : 324, "y" : 380 }, "to" : { "x" : 402, "y" : 377 } } ], "endShape" : { "a" : { "x" : 395, "y" : 381 }, "b" : { "x" : 402, "y" : 377 }, "c" : { "x" : 395, "y" : 373 }, "type" : "ARROW", "centre" : { "x" : 395, "y" : 373 } }, "reactionShape" : { "c" : { "x" : 324, "y" : 380 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 324, "y" : 380 } }, "inputs" : [ { "id" : 64428, "points" : [ { "x" : 272, "y" : 395 } ] }, { "id" : 64429, "points" : [ { "x" : 166, "y" : 367 } ] }, { "id" : 64430, "points" : [ { "x" : 183, "y" : 395 } ] } ], "outputs" : [ { "id" : 64431 } ] }, { "id" : 64461, "reactomeId" : 10082026, "displayName" : "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1034, "y" : 1057 }, "minX" : 1000, "maxX" : 1082, "minY" : 1051, "maxY" : 1063, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1000, "y" : 1057 }, "to" : { "x" : 1034, "y" : 1057 } }, { "from" : { "x" : 1034, "y" : 1057 }, "to" : { "x" : 1082, "y" : 1056 } } ], "endShape" : { "a" : { "x" : 1075, "y" : 1060 }, "b" : { "x" : 1082, "y" : 1056 }, "c" : { "x" : 1075, "y" : 1052 }, "type" : "ARROW", "centre" : { "x" : 1075, "y" : 1052 } }, "reactionShape" : { "c" : { "x" : 1034, "y" : 1057 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1034, "y" : 1057 } }, "inputs" : [ { "id" : 64462, "points" : [ { "x" : 909, "y" : 1060 } ] }, { "id" : 64463, "points" : [ { "x" : 975, "y" : 1090 } ] }, { "id" : 64464, "points" : [ { "x" : 871, "y" : 1093 } ] }, { "id" : 64465, "points" : [ { "x" : 945, "y" : 1045 } ] } ], "outputs" : [ { "id" : 64466 } ] }, { "id" : 64432, "reactomeId" : 10081005, "displayName" : "RNF144A polyubiquitinates PRKDC", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 649, "y" : 371 }, "minX" : 616, "maxX" : 689, "minY" : 365, "maxY" : 377, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 616, "y" : 376 }, "to" : { "x" : 649, "y" : 371 } }, { "from" : { "x" : 649, "y" : 371 }, "to" : { "x" : 689, "y" : 373 } } ], "reactionShape" : { "a" : { "x" : 643, "y" : 365 }, "b" : { "x" : 655, "y" : 377 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 649, "y" : 371 } }, "inputs" : [ { "id" : 64428, "points" : [ { "x" : 311, "y" : 407 }, { "x" : 579, "y" : 403 } ], "stoichiometry" : 2 }, { "id" : 64431, "points" : [ { "x" : 533, "y" : 376 } ] } ], "outputs" : [ { "id" : 64429, "points" : [ { "x" : 142, "y" : 350 }, { "x" : 195, "y" : 328 }, { "x" : 674, "y" : 332 } ] }, { "id" : 64433, "points" : [ { "x" : 728, "y" : 333 } ], "stoichiometry" : 3 }, { "id" : 64434, "points" : [ { "x" : 725, "y" : 372 } ] } ], "catalysts" : [ { "id" : 64431, "points" : [ { "x" : 533, "y" : 374 } ] } ] }, { "id" : 64467, "reactomeId" : 10082024, "displayName" : "SHPRH polyubiquitinates monoubiquitinated PCNA", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1270, "y" : 1107 }, "minX" : 1233, "maxX" : 1380, "minY" : 1101, "maxY" : 1113, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1233, "y" : 1108 }, "to" : { "x" : 1270, "y" : 1107 } }, { "from" : { "x" : 1270, "y" : 1107 }, "to" : { "x" : 1380, "y" : 1107 } } ], "reactionShape" : { "a" : { "x" : 1264, "y" : 1101 }, "b" : { "x" : 1276, "y" : 1113 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1270, "y" : 1107 } }, "inputs" : [ { "id" : 64466, "points" : [ { "x" : 1212, "y" : 1076 } ] }, { "id" : 64463, "points" : [ { "x" : 1036, "y" : 1106 } ], "stoichiometry" : 8 } ], "outputs" : [ { "id" : 64462, "points" : [ { "x" : 823, "y" : 1078 }, { "x" : 792, "y" : 1087 }, { "x" : 793, "y" : 1152 }, { "x" : 1380, "y" : 1154 } ] }, { "id" : 64464, "points" : [ { "x" : 845, "y" : 1117 }, { "x" : 868, "y" : 1144 }, { "x" : 1366, "y" : 1147 } ] }, { "id" : 64468, "points" : [ { "x" : 1437, "y" : 1121 } ], "stoichiometry" : 9 }, { "id" : 64469, "points" : [ { "x" : 1434, "y" : 1063 } ] } ], "catalysts" : [ { "id" : 64466, "points" : [ { "x" : 1224, "y" : 1076 } ] } ] }, { "id" : 64435, "reactomeId" : 10081031, "displayName" : "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1104, "y" : 559 }, "minX" : 1067, "maxX" : 1156, "minY" : 547, "maxY" : 565, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1067, "y" : 559 }, "to" : { "x" : 1104, "y" : 559 } }, { "from" : { "x" : 1104, "y" : 559 }, "to" : { "x" : 1156, "y" : 547 } } ], "endShape" : { "a" : { "x" : 1150, "y" : 552 }, "b" : { "x" : 1156, "y" : 547 }, "c" : { "x" : 1148, "y" : 545 }, "type" : "ARROW", "centre" : { "x" : 1148, "y" : 545 } }, "reactionShape" : { "c" : { "x" : 1104, "y" : 559 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1104, "y" : 559 } }, "inputs" : [ { "id" : 64436, "points" : [ { "x" : 1037, "y" : 563 } ] }, { "id" : 64437, "points" : [ { "x" : 1014, "y" : 516 } ] }, { "id" : 64438, "points" : [ { "x" : 1056, "y" : 592 } ] } ], "outputs" : [ { "id" : 64439 } ] }, { "id" : 64470, "reactomeId" : 10082037, "displayName" : "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1033, "y" : 1000 }, "minX" : 990, "maxX" : 1080, "minY" : 994, "maxY" : 1006, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 990, "y" : 1000 }, "to" : { "x" : 1033, "y" : 1000 } }, { "from" : { "x" : 1033, "y" : 1000 }, "to" : { "x" : 1080, "y" : 1000 } } ], "endShape" : { "a" : { "x" : 1073, "y" : 1004 }, "b" : { "x" : 1080, "y" : 1000 }, "c" : { "x" : 1073, "y" : 996 }, "type" : "ARROW", "centre" : { "x" : 1073, "y" : 996 } }, "reactionShape" : { "c" : { "x" : 1033, "y" : 1000 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1033, "y" : 1000 } }, "inputs" : [ { "id" : 64471, "points" : [ { "x" : 882, "y" : 972 } ] }, { "id" : 64465, "points" : [ { "x" : 936, "y" : 1018 } ] }, { "id" : 64472, "points" : [ { "x" : 970, "y" : 973 } ] }, { "id" : 64473, "points" : [ { "x" : 915, "y" : 998 } ] } ], "outputs" : [ { "id" : 64474 } ] }, { "id" : 64440, "reactomeId" : 10081029, "displayName" : "RNF152 polyubiquitinates RRAGA", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1339, "y" : 551 }, "minX" : 1317, "maxX" : 1382, "minY" : 545, "maxY" : 564, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1317, "y" : 564 }, "to" : { "x" : 1339, "y" : 551 } }, { "from" : { "x" : 1339, "y" : 551 }, "to" : { "x" : 1382, "y" : 552 } } ], "reactionShape" : { "a" : { "x" : 1333, "y" : 545 }, "b" : { "x" : 1345, "y" : 557 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1339, "y" : 551 } }, "inputs" : [ { "id" : 64439, "points" : [ { "x" : 1262, "y" : 547 } ] }, { "id" : 64438, "points" : [ { "x" : 1092, "y" : 605 }, { "x" : 1299, "y" : 603 } ], "stoichiometry" : 11 } ], "outputs" : [ { "id" : 64441, "points" : [ { "x" : 1412, "y" : 577 } ] }, { "id" : 64442, "points" : [ { "x" : 1449, "y" : 554 } ], "stoichiometry" : 12 }, { "id" : 64437, "points" : [ { "x" : 1043, "y" : 498 }, { "x" : 1384, "y" : 498 } ] } ], "catalysts" : [ { "id" : 64439, "points" : [ { "x" : 1292, "y" : 541 } ] } ] }, { "id" : 64475, "reactomeId" : 10082035, "displayName" : "HLTF polyubiquitinates monoubiquitinated PCNA", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1277, "y" : 957 }, "minX" : 1224, "maxX" : 1375, "minY" : 951, "maxY" : 963, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1224, "y" : 958 }, "to" : { "x" : 1277, "y" : 957 } }, { "from" : { "x" : 1277, "y" : 957 }, "to" : { "x" : 1375, "y" : 959 } } ], "reactionShape" : { "a" : { "x" : 1271, "y" : 951 }, "b" : { "x" : 1283, "y" : 963 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1277, "y" : 957 } }, "inputs" : [ { "id" : 64474, "points" : [ { "x" : 1207, "y" : 983 } ] }, { "id" : 64472, "points" : [ { "x" : 1035, "y" : 958 } ], "stoichiometry" : 8 } ], "outputs" : [ { "id" : 64469, "points" : [ { "x" : 1438, "y" : 1019 } ] }, { "id" : 64471, "points" : [ { "x" : 852, "y" : 952 }, { "x" : 855, "y" : 924 }, { "x" : 1363, "y" : 929 } ] }, { "id" : 64473, "points" : [ { "x" : 816, "y" : 985 }, { "x" : 788, "y" : 981 }, { "x" : 784, "y" : 911 }, { "x" : 1368, "y" : 916 } ] }, { "id" : 64476, "points" : [ { "x" : 1421, "y" : 949 } ], "stoichiometry" : 9 } ], "catalysts" : [ { "id" : 64474, "points" : [ { "x" : 1225, "y" : 983 } ] } ] }, { "id" : 64443, "reactomeId" : 10081135, "displayName" : "RNF181 binds BCL10 and Ubiquitin:E2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1096, "y" : 86 }, "minX" : 1066, "maxX" : 1130, "minY" : 80, "maxY" : 92, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1066, "y" : 87 }, "to" : { "x" : 1096, "y" : 86 } }, { "from" : { "x" : 1096, "y" : 86 }, "to" : { "x" : 1130, "y" : 86 } } ], "endShape" : { "a" : { "x" : 1123, "y" : 90 }, "b" : { "x" : 1130, "y" : 86 }, "c" : { "x" : 1123, "y" : 82 }, "type" : "ARROW", "centre" : { "x" : 1123, "y" : 82 } }, "reactionShape" : { "c" : { "x" : 1096, "y" : 86 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1096, "y" : 86 } }, "inputs" : [ { "id" : 64444, "points" : [ { "x" : 1042, "y" : 93 } ] }, { "id" : 64445, "points" : [ { "x" : 1015, "y" : 69 } ] }, { "id" : 64446, "points" : [ { "x" : 1058, "y" : 121 } ] } ], "outputs" : [ { "id" : 64447 } ] }, { "id" : 64477, "reactomeId" : 10083933, "displayName" : "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1287, "y" : 759 }, "minX" : 1241, "maxX" : 1366, "minY" : 753, "maxY" : 765, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1241, "y" : 756 }, "to" : { "x" : 1287, "y" : 759 } }, { "from" : { "x" : 1287, "y" : 759 }, "to" : { "x" : 1366, "y" : 758 } } ], "reactionShape" : { "a" : { "x" : 1281, "y" : 753 }, "b" : { "x" : 1293, "y" : 765 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1287, "y" : 759 } }, "inputs" : [ { "id" : 64478 } ], "outputs" : [ { "id" : 64479, "points" : [ { "x" : 1395, "y" : 813 } ] }, { "id" : 64480, "points" : [ { "x" : 1408, "y" : 749 } ] } ], "catalysts" : [ { "id" : 64478, "points" : [ { "x" : 1241, "y" : 763 } ] } ] } ], "compartments" : [ { "id" : 64484, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 828, "y" : 773 }, "minX" : 0, "maxX" : 1657, "minY" : 0, "maxY" : 1547, "prop" : { "x" : 0, "y" : 0, "width" : 1657, "height" : 1547 }, "textPosition" : { "x" : 21, "y" : 1461 }, "insets" : { "x" : 10, "y" : 10, "width" : 1637, "height" : 1527 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 64485, 64486, 64428, 64430, 64433, 64434, 64487, 64440, 64441, 64443, 64444, 64447, 64448, 64449, 64445, 64450, 64442, 64427, 64488, 64432, 64489, 64435, 64436, 64438, 64479, 64446, 64483 ] }, { "id" : 64485, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 836, "y" : 1179 }, "minX" : 108, "maxX" : 1564, "minY" : 885, "maxY" : 1474, "prop" : { "x" : 108, "y" : 885, "width" : 1456, "height" : 589 }, "textPosition" : { "x" : 125, "y" : 1418 }, "insets" : { "x" : 118, "y" : 895, "width" : 1436, "height" : 569 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 64451, 64452, 64453, 64454, 64455, 64457, 64458, 64459, 64460, 64462, 64463, 64464, 64465, 64466, 64461, 64467, 64468, 64469, 64470, 64474, 64471, 64472, 64473, 64475, 64476, 64456 ] }, { "id" : 64486, "reactomeId" : 17940, "displayName" : "endosome", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 313, "y" : 322 }, "minX" : 53, "maxX" : 573, "minY" : 277, "maxY" : 367, "prop" : { "x" : 53, "y" : 277, "width" : 520, "height" : 90 }, "textPosition" : { "x" : 66, "y" : 304 }, "insets" : { "x" : 63, "y" : 287, "width" : 500, "height" : 70 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 64429, 64431 ] }, { "id" : 64487, "reactomeId" : 17938, "displayName" : "lysosomal membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1173, "y" : 498 }, "minX" : 934, "maxX" : 1413, "minY" : 454, "maxY" : 543, "prop" : { "x" : 934, "y" : 454, "width" : 479, "height" : 89 }, "textPosition" : { "x" : 1099, "y" : 457 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 64437, 64439 ] }, { "id" : 64488, "reactomeId" : 12045, "displayName" : "endoplasmic reticulum membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 429, "y" : 582 }, "minX" : 21, "maxX" : 838, "minY" : 472, "maxY" : 693, "prop" : { "x" : 21, "y" : 472, "width" : 817, "height" : 221 }, "textPosition" : { "x" : 24, "y" : 585 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 64489, "reactomeId" : 17947, "displayName" : "peroxisomal membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1235, "y" : 727 }, "minX" : 916, "maxX" : 1554, "minY" : 654, "maxY" : 801, "prop" : { "x" : 916, "y" : 654, "width" : 638, "height" : 147 }, "textPosition" : { "x" : 1336, "y" : 657 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 64477, 64480, 64478, 64481, 64482 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ ], "minX" : 0, "maxX" : 1657, "minY" : 0, "maxY" : 1547, "disease" : false }