{
  "dbId" : 10099789,
  "stableId" : "R-MMU-201681",
  "displayName" : "TCF dependent signaling in response to WNT",
  "nodes" : [ {
    "id" : 74753,
    "reactomeId" : 9994172,
    "displayName" : "PP2A",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1755,
      "y" : 1250
    },
    "minX" : 1682,
    "maxX" : 1789,
    "minY" : 1196,
    "maxY" : 1261,
    "prop" : {
      "x" : 1728,
      "y" : 1239,
      "width" : 55,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1735,
      "y" : 1240
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1783,
          "y" : 1239
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1783,
          "y" : 1239
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74750,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1740,
          "y" : 1236
        },
        "to" : {
          "x" : 1682,
          "y" : 1196
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1732,
          "y" : 1235
        },
        "b" : {
          "x" : 1740,
          "y" : 1236
        },
        "c" : {
          "x" : 1737,
          "y" : 1229
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1737,
          "y" : 1229
        }
      }
    } ]
  }, {
    "id" : 74752,
    "reactomeId" : 10002056,
    "displayName" : "Apc",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1583,
      "y" : 1269
    },
    "minX" : 1539,
    "maxX" : 1682,
    "minY" : 1196,
    "maxY" : 1283,
    "prop" : {
      "x" : 1539,
      "y" : 1256,
      "width" : 89,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1568,
      "y" : 1259
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1628,
          "y" : 1256
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1628,
          "y" : 1256
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74750,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1601,
          "y" : 1253
        },
        "to" : {
          "x" : 1682,
          "y" : 1196
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1604,
          "y" : 1246
        },
        "b" : {
          "x" : 1601,
          "y" : 1253
        },
        "c" : {
          "x" : 1609,
          "y" : 1252
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1609,
          "y" : 1252
        }
      }
    } ]
  }, {
    "id" : 74755,
    "reactomeId" : 10002041,
    "displayName" : "CSNK1A1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1685,
      "y" : 1267
    },
    "minX" : 1650,
    "maxX" : 1727,
    "minY" : 1196,
    "maxY" : 1281,
    "prop" : {
      "x" : 1650,
      "y" : 1254,
      "width" : 71,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1653,
      "y" : 1257
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1721,
          "y" : 1254
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1721,
          "y" : 1254
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74750,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1684,
          "y" : 1251
        },
        "to" : {
          "x" : 1682,
          "y" : 1196
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1680,
          "y" : 1244
        },
        "b" : {
          "x" : 1684,
          "y" : 1251
        },
        "c" : {
          "x" : 1688,
          "y" : 1244
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1688,
          "y" : 1244
        }
      }
    } ]
  }, {
    "id" : 74754,
    "reactomeId" : 10002048,
    "displayName" : "Amer1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1575,
      "y" : 1209
    },
    "minX" : 1540,
    "maxX" : 1682,
    "minY" : 1191,
    "maxY" : 1222,
    "prop" : {
      "x" : 1540,
      "y" : 1197,
      "width" : 70,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1551,
      "y" : 1199
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1610,
          "y" : 1197
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1610,
          "y" : 1197
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74750,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1613,
          "y" : 1204
        },
        "to" : {
          "x" : 1682,
          "y" : 1196
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1619,
          "y" : 1199
        },
        "b" : {
          "x" : 1613,
          "y" : 1204
        },
        "c" : {
          "x" : 1620,
          "y" : 1207
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1620,
          "y" : 1207
        }
      }
    } ]
  }, {
    "id" : 74756,
    "reactomeId" : 10004017,
    "displayName" : "WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2348,
      "y" : 422
    },
    "minX" : 1694,
    "maxX" : 2413,
    "minY" : 384,
    "maxY" : 1160,
    "prop" : {
      "x" : 2290,
      "y" : 390,
      "width" : 117,
      "height" : 64
    },
    "textPosition" : {
      "x" : 2291,
      "y" : 405
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2407,
          "y" : 390
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2407,
          "y" : 390
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74750,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 2321,
          "y" : 457
        },
        "to" : {
          "x" : 1933,
          "y" : 917
        }
      }, {
        "from" : {
          "x" : 1933,
          "y" : 917
        },
        "to" : {
          "x" : 1905,
          "y" : 1036
        }
      }, {
        "from" : {
          "x" : 1905,
          "y" : 1036
        },
        "to" : {
          "x" : 1694,
          "y" : 1160
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1698,
          "y" : 1153
        },
        "b" : {
          "x" : 1694,
          "y" : 1160
        },
        "c" : {
          "x" : 1702,
          "y" : 1160
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1702,
          "y" : 1160
        }
      }
    } ]
  }, {
    "id" : 74759,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1870,
      "y" : 479
    },
    "minX" : 1845,
    "maxX" : 1893,
    "minY" : 418,
    "maxY" : 493,
    "prop" : {
      "x" : 1849,
      "y" : 466,
      "width" : 43,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1854,
      "y" : 469
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1887,
          "y" : 471
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1887,
          "y" : 471
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74757,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1864,
          "y" : 463
        },
        "to" : {
          "x" : 1845,
          "y" : 418
        }
      } ],
      "stoichiometry" : {
        "value" : 5,
        "shape" : {
          "a" : {
            "x" : 1848,
            "y" : 434
          },
          "b" : {
            "x" : 1860,
            "y" : 446
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1854,
            "y" : 440
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1858,
          "y" : 458
        },
        "b" : {
          "x" : 1864,
          "y" : 463
        },
        "c" : {
          "x" : 1865,
          "y" : 455
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1865,
          "y" : 455
        }
      }
    } ]
  }, {
    "id" : 74758,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1722,
      "y" : 477
    },
    "minX" : 1699,
    "maxX" : 1768,
    "minY" : 420,
    "maxY" : 492,
    "prop" : {
      "x" : 1699,
      "y" : 463,
      "width" : 47,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1707,
      "y" : 467
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1741,
          "y" : 468
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1741,
          "y" : 468
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74757,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1733,
          "y" : 460
        },
        "to" : {
          "x" : 1768,
          "y" : 420
        }
      } ],
      "stoichiometry" : {
        "value" : 5,
        "shape" : {
          "a" : {
            "x" : 1744,
            "y" : 434
          },
          "b" : {
            "x" : 1756,
            "y" : 446
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1750,
            "y" : 440
          }
        }
      }
    } ]
  }, {
    "id" : 74760,
    "reactomeId" : 10004002,
    "displayName" : "WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1946,
      "y" : 419
    },
    "minX" : 1845,
    "maxX" : 2010,
    "minY" : 381,
    "maxY" : 451,
    "prop" : {
      "x" : 1889,
      "y" : 387,
      "width" : 115,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1890,
      "y" : 402
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2004,
          "y" : 387
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2004,
          "y" : 387
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74757,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1886,
          "y" : 418
        },
        "to" : {
          "x" : 1845,
          "y" : 418
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1879,
          "y" : 422
        },
        "b" : {
          "x" : 1886,
          "y" : 418
        },
        "c" : {
          "x" : 1879,
          "y" : 414
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1879,
          "y" : 414
        }
      }
    } ]
  }, {
    "id" : 74763,
    "reactomeId" : 10004030,
    "displayName" : "BCL9",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2905,
      "y" : 1345
    },
    "minX" : 2847,
    "maxX" : 2926,
    "minY" : 1300,
    "maxY" : 1356,
    "prop" : {
      "x" : 2885,
      "y" : 1334,
      "width" : 41,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2886,
      "y" : 1334
    },
    "connectors" : [ {
      "edgeId" : 74761,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2890,
          "y" : 1328
        },
        "to" : {
          "x" : 2847,
          "y" : 1300
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74762,
    "reactomeId" : 10004057,
    "displayName" : "TCF/LEF:CTNNB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2698,
      "y" : 1291
    },
    "minX" : 2379,
    "maxX" : 2854,
    "minY" : 1162,
    "maxY" : 1453,
    "prop" : {
      "x" : 2638,
      "y" : 1280,
      "width" : 121,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2644,
      "y" : 1282
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2759,
          "y" : 1280
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2759,
          "y" : 1280
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74761,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2762,
          "y" : 1294
        },
        "to" : {
          "x" : 2847,
          "y" : 1300
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74766,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2635,
          "y" : 1291
        },
        "to" : {
          "x" : 2595,
          "y" : 1291
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2628,
          "y" : 1295
        },
        "b" : {
          "x" : 2635,
          "y" : 1291
        },
        "c" : {
          "x" : 2628,
          "y" : 1287
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2628,
          "y" : 1287
        }
      }
    }, {
      "edgeId" : 74770,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2711,
          "y" : 1277
        },
        "to" : {
          "x" : 2854,
          "y" : 1162
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74773,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2719,
          "y" : 1277
        },
        "to" : {
          "x" : 2829,
          "y" : 1220
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74777,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2696,
          "y" : 1277
        },
        "to" : {
          "x" : 2681,
          "y" : 1170
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74918,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2689,
          "y" : 1306
        },
        "to" : {
          "x" : 2646,
          "y" : 1360
        }
      }, {
        "from" : {
          "x" : 2646,
          "y" : 1360
        },
        "to" : {
          "x" : 2379,
          "y" : 1453
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74765,
    "reactomeId" : 10004059,
    "displayName" : "TCF/LEF:CTNNB1:BCL9:PYGO",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2985,
      "y" : 1303
    },
    "minX" : 2926,
    "maxX" : 3087,
    "minY" : 1276,
    "maxY" : 1325,
    "prop" : {
      "x" : 2926,
      "y" : 1282,
      "width" : 118,
      "height" : 43
    },
    "textPosition" : {
      "x" : 2929,
      "y" : 1290
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3044,
          "y" : 1282
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3044,
          "y" : 1282
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74761,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74781,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3047,
          "y" : 1305
        },
        "to" : {
          "x" : 3087,
          "y" : 1307
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74764,
    "reactomeId" : 10004040,
    "displayName" : "PYGO",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2811,
      "y" : 1354
    },
    "minX" : 2789,
    "maxX" : 2847,
    "minY" : 1300,
    "maxY" : 1365,
    "prop" : {
      "x" : 2789,
      "y" : 1343,
      "width" : 44,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2790,
      "y" : 1343
    },
    "connectors" : [ {
      "edgeId" : 74761,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2818,
          "y" : 1337
        },
        "to" : {
          "x" : 2847,
          "y" : 1300
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74767,
    "reactomeId" : 10048369,
    "displayName" : "TCF/LEF:TLE:HDAC1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2452,
      "y" : 1292
    },
    "minX" : 2408,
    "maxX" : 3650,
    "minY" : 1268,
    "maxY" : 1588,
    "prop" : {
      "x" : 2408,
      "y" : 1274,
      "width" : 89,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2410,
      "y" : 1275
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2497,
          "y" : 1274
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2497,
          "y" : 1274
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74766,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2500,
          "y" : 1291
        },
        "to" : {
          "x" : 2525,
          "y" : 1291
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74805,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2452,
          "y" : 1313
        },
        "to" : {
          "x" : 2452,
          "y" : 1579
        }
      }, {
        "from" : {
          "x" : 2452,
          "y" : 1579
        },
        "to" : {
          "x" : 3624,
          "y" : 1588
        }
      }, {
        "from" : {
          "x" : 3624,
          "y" : 1588
        },
        "to" : {
          "x" : 3650,
          "y" : 1294
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2456,
          "y" : 1320
        },
        "b" : {
          "x" : 2452,
          "y" : 1313
        },
        "c" : {
          "x" : 2448,
          "y" : 1320
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2448,
          "y" : 1320
        }
      }
    } ]
  }, {
    "id" : 74769,
    "reactomeId" : 10048365,
    "displayName" : "TLE tetramer",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2535,
      "y" : 1350
    },
    "minX" : 2491,
    "maxX" : 2595,
    "minY" : 1291,
    "maxY" : 1403,
    "prop" : {
      "x" : 2491,
      "y" : 1339,
      "width" : 89,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2491,
      "y" : 1339
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 74766,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2546,
          "y" : 1333
        },
        "to" : {
          "x" : 2595,
          "y" : 1291
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2549,
          "y" : 1325
        },
        "b" : {
          "x" : 2546,
          "y" : 1333
        },
        "c" : {
          "x" : 2554,
          "y" : 1332
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2554,
          "y" : 1332
        }
      }
    }, {
      "edgeId" : 74799,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2542,
          "y" : 1367
        },
        "to" : {
          "x" : 2573,
          "y" : 1403
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74768,
    "reactomeId" : 573340,
    "displayName" : "Hdac1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2621,
      "y" : 1328
    },
    "minX" : 2593,
    "maxX" : 2656,
    "minY" : 1291,
    "maxY" : 1339,
    "prop" : {
      "x" : 2593,
      "y" : 1317,
      "width" : 57,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2597,
      "y" : 1317
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2650,
          "y" : 1317
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2650,
          "y" : 1317
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74766,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2613,
          "y" : 1314
        },
        "to" : {
          "x" : 2595,
          "y" : 1291
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2606,
          "y" : 1311
        },
        "b" : {
          "x" : 2613,
          "y" : 1314
        },
        "c" : {
          "x" : 2612,
          "y" : 1306
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2612,
          "y" : 1306
        }
      }
    } ]
  }, {
    "id" : 74771,
    "reactomeId" : 10022649,
    "displayName" : "CREBBP,EP300",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2770,
      "y" : 1160
    },
    "minX" : 2723,
    "maxX" : 2854,
    "minY" : 1149,
    "maxY" : 1171,
    "prop" : {
      "x" : 2723,
      "y" : 1149,
      "width" : 95,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2740,
      "y" : 1143
    },
    "connectors" : [ {
      "edgeId" : 74770,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2824,
          "y" : 1161
        },
        "to" : {
          "x" : 2854,
          "y" : 1162
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74772,
    "reactomeId" : 10048685,
    "displayName" : "TCF/LEF:CTNNB1:CBP/p300",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3000,
      "y" : 1141
    },
    "minX" : 2941,
    "maxX" : 3066,
    "minY" : 1116,
    "maxY" : 1161,
    "prop" : {
      "x" : 2941,
      "y" : 1122,
      "width" : 119,
      "height" : 39
    },
    "textPosition" : {
      "x" : 2944,
      "y" : 1126
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3060,
          "y" : 1122
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3060,
          "y" : 1122
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74770,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74775,
    "reactomeId" : 9992662,
    "displayName" : "Cdc73",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2856,
      "y" : 1262
    },
    "minX" : 2829,
    "maxX" : 2887,
    "minY" : 1220,
    "maxY" : 1273,
    "prop" : {
      "x" : 2831,
      "y" : 1251,
      "width" : 50,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2832,
      "y" : 1251
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2881,
          "y" : 1251
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2881,
          "y" : 1251
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74773,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2848,
          "y" : 1248
        },
        "to" : {
          "x" : 2829,
          "y" : 1220
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74774,
    "reactomeId" : 9992670,
    "displayName" : "Leo1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2796,
      "y" : 1274
    },
    "minX" : 2777,
    "maxX" : 2829,
    "minY" : 1220,
    "maxY" : 1285,
    "prop" : {
      "x" : 2777,
      "y" : 1263,
      "width" : 39,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2777,
      "y" : 1263
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2816,
          "y" : 1263
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2816,
          "y" : 1263
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74773,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2802,
          "y" : 1260
        },
        "to" : {
          "x" : 2829,
          "y" : 1220
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74776,
    "reactomeId" : 10048681,
    "displayName" : "TCF/LEF:CTNNB1:PAF1-like complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3010,
      "y" : 1214
    },
    "minX" : 2952,
    "maxX" : 3074,
    "minY" : 1184,
    "maxY" : 1238,
    "prop" : {
      "x" : 2952,
      "y" : 1190,
      "width" : 116,
      "height" : 48
    },
    "textPosition" : {
      "x" : 2954,
      "y" : 1189
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3068,
          "y" : 1190
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3068,
          "y" : 1190
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74773,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74779,
    "reactomeId" : 9995447,
    "displayName" : "TERT",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2650,
      "y" : 1243
    },
    "minX" : 2630,
    "maxX" : 2681,
    "minY" : 1170,
    "maxY" : 1254,
    "prop" : {
      "x" : 2630,
      "y" : 1232,
      "width" : 40,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2631,
      "y" : 1232
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2670,
          "y" : 1232
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2670,
          "y" : 1232
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74777,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2654,
          "y" : 1229
        },
        "to" : {
          "x" : 2681,
          "y" : 1170
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74778,
    "reactomeId" : 10047574,
    "displayName" : "SMARCA4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2618,
      "y" : 1209
    },
    "minX" : 2585,
    "maxX" : 2681,
    "minY" : 1170,
    "maxY" : 1220,
    "prop" : {
      "x" : 2585,
      "y" : 1198,
      "width" : 67,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2585,
      "y" : 1198
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2652,
          "y" : 1198
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2652,
          "y" : 1198
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74777,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2635,
          "y" : 1195
        },
        "to" : {
          "x" : 2681,
          "y" : 1170
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74780,
    "reactomeId" : 10048677,
    "displayName" : "TCF/LEF:CTNNB1:SMARCA4:TERT",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2678,
      "y" : 1028
    },
    "minX" : 2622,
    "maxX" : 2741,
    "minY" : 1004,
    "maxY" : 1046,
    "prop" : {
      "x" : 2622,
      "y" : 1010,
      "width" : 113,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2622,
      "y" : 1011
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2735,
          "y" : 1010
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2735,
          "y" : 1010
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74777,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74783,
    "reactomeId" : 10048860,
    "displayName" : "TCF/LEF:CTNNB1:BCL9:PYGO:MLL2:MEN1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3225,
      "y" : 1292
    },
    "minX" : 3179,
    "maxX" : 3278,
    "minY" : 1249,
    "maxY" : 1330,
    "prop" : {
      "x" : 3179,
      "y" : 1255,
      "width" : 93,
      "height" : 75
    },
    "textPosition" : {
      "x" : 3185,
      "y" : 1253
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3272,
          "y" : 1255
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3272,
          "y" : 1255
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74781,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74782,
    "reactomeId" : 10048858,
    "displayName" : "MLL2 complex:MEN1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3076,
      "y" : 1353
    },
    "minX" : 3007,
    "maxX" : 3152,
    "minY" : 1307,
    "maxY" : 1366,
    "prop" : {
      "x" : 3007,
      "y" : 1341,
      "width" : 139,
      "height" : 25
    },
    "textPosition" : {
      "x" : 3010,
      "y" : 1345
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3146,
          "y" : 1341
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3146,
          "y" : 1341
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74781,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3078,
          "y" : 1338
        },
        "to" : {
          "x" : 3087,
          "y" : 1307
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74785,
    "reactomeId" : 10049099,
    "displayName" : "TNKS1/2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 730,
      "y" : 1752
    },
    "minX" : 699,
    "maxX" : 1130,
    "minY" : 1663,
    "maxY" : 1797,
    "prop" : {
      "x" : 699,
      "y" : 1741,
      "width" : 62,
      "height" : 22
    },
    "textPosition" : {
      "x" : 700,
      "y" : 1741
    },
    "connectors" : [ {
      "edgeId" : 74784,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 730,
          "y" : 1769
        },
        "to" : {
          "x" : 733,
          "y" : 1797
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74798,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 767,
          "y" : 1745
        },
        "to" : {
          "x" : 1130,
          "y" : 1663
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 773,
          "y" : 1740
        },
        "b" : {
          "x" : 767,
          "y" : 1745
        },
        "c" : {
          "x" : 775,
          "y" : 1747
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 775,
          "y" : 1747
        }
      }
    } ]
  }, {
    "id" : 74787,
    "reactomeId" : 10049111,
    "displayName" : "AXIN:TNKS",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 817,
      "y" : 1797
    },
    "minX" : 781,
    "maxX" : 896,
    "minY" : 1765,
    "maxY" : 1808,
    "prop" : {
      "x" : 781,
      "y" : 1786,
      "width" : 72,
      "height" : 22
    },
    "textPosition" : {
      "x" : 782,
      "y" : 1787
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 853,
          "y" : 1786
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 853,
          "y" : 1786
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74784,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74788,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 856,
          "y" : 1796
        },
        "to" : {
          "x" : 878,
          "y" : 1796
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74788,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 834,
          "y" : 1783
        },
        "to" : {
          "x" : 869,
          "y" : 1765
        }
      }, {
        "from" : {
          "x" : 869,
          "y" : 1765
        },
        "to" : {
          "x" : 890,
          "y" : 1785
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 892,
          "y" : 1788
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 892,
          "y" : 1788
        }
      }
    } ]
  }, {
    "id" : 74786,
    "reactomeId" : 10049109,
    "displayName" : "AXIN",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 602,
      "y" : 1797
    },
    "minX" : 584,
    "maxX" : 733,
    "minY" : 1573,
    "maxY" : 1808,
    "prop" : {
      "x" : 584,
      "y" : 1786,
      "width" : 37,
      "height" : 22
    },
    "textPosition" : {
      "x" : 585,
      "y" : 1786
    },
    "connectors" : [ {
      "edgeId" : 74784,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 627,
          "y" : 1797
        },
        "to" : {
          "x" : 733,
          "y" : 1797
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74872,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 606,
          "y" : 1780
        },
        "to" : {
          "x" : 693,
          "y" : 1573
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74789,
    "reactomeId" : 29360,
    "displayName" : "NAD+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 839,
      "y" : 1836
    },
    "minX" : 813,
    "maxX" : 878,
    "minY" : 1796,
    "maxY" : 1851,
    "prop" : {
      "x" : 813,
      "y" : 1821,
      "width" : 53,
      "height" : 30
    },
    "textPosition" : {
      "x" : 817,
      "y" : 1825
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 861,
          "y" : 1826
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 861,
          "y" : 1826
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74788,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 853,
          "y" : 1818
        },
        "to" : {
          "x" : 878,
          "y" : 1796
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74791,
    "reactomeId" : 197277,
    "displayName" : "NAM",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 943,
      "y" : 1845
    },
    "minX" : 920,
    "maxX" : 967,
    "minY" : 1796,
    "maxY" : 1860,
    "prop" : {
      "x" : 921,
      "y" : 1830,
      "width" : 45,
      "height" : 30
    },
    "textPosition" : {
      "x" : 926,
      "y" : 1834
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 961,
          "y" : 1835
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 961,
          "y" : 1835
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74788,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 935,
          "y" : 1827
        },
        "to" : {
          "x" : 920,
          "y" : 1796
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 928,
          "y" : 1823
        },
        "b" : {
          "x" : 935,
          "y" : 1827
        },
        "c" : {
          "x" : 936,
          "y" : 1819
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 936,
          "y" : 1819
        }
      }
    } ]
  }, {
    "id" : 74790,
    "reactomeId" : 10049101,
    "displayName" : "RibC-AXIN:TNKS",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 998,
      "y" : 1796
    },
    "minX" : 920,
    "maxX" : 1069,
    "minY" : 1779,
    "maxY" : 1807,
    "prop" : {
      "x" : 945,
      "y" : 1785,
      "width" : 106,
      "height" : 22
    },
    "textPosition" : {
      "x" : 947,
      "y" : 1786
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1051,
          "y" : 1785
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1051,
          "y" : 1785
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74788,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 942,
          "y" : 1796
        },
        "to" : {
          "x" : 920,
          "y" : 1796
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 935,
          "y" : 1800
        },
        "b" : {
          "x" : 942,
          "y" : 1796
        },
        "c" : {
          "x" : 935,
          "y" : 1792
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 935,
          "y" : 1792
        }
      }
    }, {
      "edgeId" : 74796,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1054,
          "y" : 1794
        },
        "to" : {
          "x" : 1069,
          "y" : 1794
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74793,
    "reactomeId" : 10049103,
    "displayName" : "RibC-AXIN:TNKS:RNF146",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1168,
      "y" : 1794
    },
    "minX" : 1114,
    "maxX" : 1350,
    "minY" : 1770,
    "maxY" : 1866,
    "prop" : {
      "x" : 1114,
      "y" : 1776,
      "width" : 109,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1116,
      "y" : 1777
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1223,
          "y" : 1776
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1223,
          "y" : 1776
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74792,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1226,
          "y" : 1792
        },
        "to" : {
          "x" : 1248,
          "y" : 1792
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74792,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1226,
          "y" : 1810
        },
        "to" : {
          "x" : 1263,
          "y" : 1823
        }
      }, {
        "from" : {
          "x" : 1263,
          "y" : 1823
        },
        "to" : {
          "x" : 1274,
          "y" : 1808
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1277,
          "y" : 1805
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1277,
          "y" : 1805
        }
      }
    }, {
      "edgeId" : 74796,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74857,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1213,
          "y" : 1815
        },
        "to" : {
          "x" : 1350,
          "y" : 1866
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1221,
          "y" : 1814
        },
        "b" : {
          "x" : 1213,
          "y" : 1815
        },
        "c" : {
          "x" : 1218,
          "y" : 1821
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1218,
          "y" : 1821
        }
      }
    } ]
  }, {
    "id" : 74795,
    "reactomeId" : 10049124,
    "displayName" : "Ub-RibC-AXIN:TNKS:RNF146",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1485,
      "y" : 1787
    },
    "minX" : 1420,
    "maxX" : 1557,
    "minY" : 1763,
    "maxY" : 1855,
    "prop" : {
      "x" : 1420,
      "y" : 1769,
      "width" : 131,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1422,
      "y" : 1770
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1551,
          "y" : 1769
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1551,
          "y" : 1769
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74792,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74798,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74857,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1480,
          "y" : 1808
        },
        "to" : {
          "x" : 1469,
          "y" : 1855
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74794,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1243,
      "y" : 1697
    },
    "minX" : 1130,
    "maxX" : 1350,
    "minY" : 1663,
    "maxY" : 1866,
    "prop" : {
      "x" : 1205,
      "y" : 1686,
      "width" : 76,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1230,
      "y" : 1686
    },
    "connectors" : [ {
      "edgeId" : 74792,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1243,
          "y" : 1714
        },
        "to" : {
          "x" : 1248,
          "y" : 1792
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74798,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1206,
          "y" : 1680
        },
        "to" : {
          "x" : 1130,
          "y" : 1663
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1198,
          "y" : 1682
        },
        "b" : {
          "x" : 1206,
          "y" : 1680
        },
        "c" : {
          "x" : 1200,
          "y" : 1675
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1200,
          "y" : 1675
        }
      }
    }, {
      "edgeId" : 74857,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1249,
          "y" : 1714
        },
        "to" : {
          "x" : 1350,
          "y" : 1866
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1256,
          "y" : 1718
        },
        "b" : {
          "x" : 1249,
          "y" : 1714
        },
        "c" : {
          "x" : 1250,
          "y" : 1722
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1250,
          "y" : 1722
        }
      }
    } ]
  }, {
    "id" : 74797,
    "reactomeId" : 10049079,
    "displayName" : "RNF146",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1029,
      "y" : 1754
    },
    "minX" : 1001,
    "maxX" : 1130,
    "minY" : 1663,
    "maxY" : 1794,
    "prop" : {
      "x" : 1001,
      "y" : 1743,
      "width" : 57,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1001,
      "y" : 1743
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1058,
          "y" : 1743
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1058,
          "y" : 1743
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74796,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1040,
          "y" : 1768
        },
        "to" : {
          "x" : 1069,
          "y" : 1794
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74798,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1041,
          "y" : 1740
        },
        "to" : {
          "x" : 1130,
          "y" : 1663
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1044,
          "y" : 1732
        },
        "b" : {
          "x" : 1041,
          "y" : 1740
        },
        "c" : {
          "x" : 1049,
          "y" : 1738
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1049,
          "y" : 1738
        }
      }
    } ]
  }, {
    "id" : 74801,
    "reactomeId" : 10048691,
    "displayName" : "TLE:XIAP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2669,
      "y" : 1406
    },
    "minX" : 2626,
    "maxX" : 2753,
    "minY" : 1377,
    "maxY" : 1418,
    "prop" : {
      "x" : 2626,
      "y" : 1395,
      "width" : 86,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2639,
      "y" : 1397
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2712,
          "y" : 1395
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2712,
          "y" : 1395
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74799,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74802,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2715,
          "y" : 1410
        },
        "to" : {
          "x" : 2742,
          "y" : 1413
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74802,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2686,
          "y" : 1392
        },
        "to" : {
          "x" : 2714,
          "y" : 1377
        }
      }, {
        "from" : {
          "x" : 2714,
          "y" : 1377
        },
        "to" : {
          "x" : 2746,
          "y" : 1401
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2749,
          "y" : 1404
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2749,
          "y" : 1404
        }
      }
    } ]
  }, {
    "id" : 74800,
    "reactomeId" : 10048689,
    "displayName" : "XIAP",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2535,
      "y" : 1436
    },
    "minX" : 2516,
    "maxX" : 2916,
    "minY" : 1403,
    "maxY" : 1543,
    "prop" : {
      "x" : 2516,
      "y" : 1425,
      "width" : 38,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2518,
      "y" : 1425
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2554,
          "y" : 1425
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2554,
          "y" : 1425
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74799,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2547,
          "y" : 1422
        },
        "to" : {
          "x" : 2573,
          "y" : 1403
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74809,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2544,
          "y" : 1450
        },
        "to" : {
          "x" : 2629,
          "y" : 1543
        }
      }, {
        "from" : {
          "x" : 2629,
          "y" : 1543
        },
        "to" : {
          "x" : 2866,
          "y" : 1541
        }
      }, {
        "from" : {
          "x" : 2866,
          "y" : 1541
        },
        "to" : {
          "x" : 2916,
          "y" : 1418
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2552,
          "y" : 1452
        },
        "b" : {
          "x" : 2544,
          "y" : 1450
        },
        "c" : {
          "x" : 2546,
          "y" : 1458
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2546,
          "y" : 1458
        }
      }
    } ]
  }, {
    "id" : 74803,
    "reactomeId" : 9984989,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2706,
      "y" : 1479
    },
    "minX" : 2674,
    "maxX" : 2742,
    "minY" : 1413,
    "maxY" : 1490,
    "prop" : {
      "x" : 2674,
      "y" : 1468,
      "width" : 65,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2694,
      "y" : 1468
    },
    "connectors" : [ {
      "edgeId" : 74802,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2712,
          "y" : 1462
        },
        "to" : {
          "x" : 2742,
          "y" : 1413
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74804,
    "reactomeId" : 10048715,
    "displayName" : "ub-TLE:XIAP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2834,
      "y" : 1415
    },
    "minX" : 2789,
    "maxX" : 2885,
    "minY" : 1394,
    "maxY" : 1431,
    "prop" : {
      "x" : 2789,
      "y" : 1400,
      "width" : 90,
      "height" : 31
    },
    "textPosition" : {
      "x" : 2794,
      "y" : 1410
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2879,
          "y" : 1400
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2879,
          "y" : 1400
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74802,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74809,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74807,
    "reactomeId" : 10048833,
    "displayName" : "TCF/LEF:CTNNB1:APC:CTBP:BTRC",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3503,
      "y" : 1298
    },
    "minX" : 3442,
    "maxX" : 3589,
    "minY" : 1269,
    "maxY" : 1321,
    "prop" : {
      "x" : 3442,
      "y" : 1275,
      "width" : 122,
      "height" : 46
    },
    "textPosition" : {
      "x" : 3447,
      "y" : 1286
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3564,
          "y" : 1275
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3564,
          "y" : 1275
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74805,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3567,
          "y" : 1296
        },
        "to" : {
          "x" : 3589,
          "y" : 1296
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74806,
    "reactomeId" : 10048835,
    "displayName" : "TLE1:HDAC1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3545,
      "y" : 1230
    },
    "minX" : 3513,
    "maxX" : 3589,
    "minY" : 1207,
    "maxY" : 1296,
    "prop" : {
      "x" : 3513,
      "y" : 1213,
      "width" : 65,
      "height" : 35
    },
    "textPosition" : {
      "x" : 3520,
      "y" : 1213
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3578,
          "y" : 1213
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3578,
          "y" : 1213
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74805,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3556,
          "y" : 1251
        },
        "to" : {
          "x" : 3589,
          "y" : 1296
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74808,
    "reactomeId" : 10048837,
    "displayName" : "APC:CTBP:CTNNB1:BTRC",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3729,
      "y" : 1295
    },
    "minX" : 3650,
    "maxX" : 3780,
    "minY" : 1261,
    "maxY" : 1324,
    "prop" : {
      "x" : 3684,
      "y" : 1267,
      "width" : 90,
      "height" : 57
    },
    "textPosition" : {
      "x" : 3693,
      "y" : 1275
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3774,
          "y" : 1267
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3774,
          "y" : 1267
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74805,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3681,
          "y" : 1294
        },
        "to" : {
          "x" : 3650,
          "y" : 1294
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3674,
          "y" : 1298
        },
        "b" : {
          "x" : 3681,
          "y" : 1294
        },
        "c" : {
          "x" : 3674,
          "y" : 1290
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3674,
          "y" : 1290
        }
      }
    } ]
  }, {
    "id" : 74810,
    "reactomeId" : 10048713,
    "displayName" : "ub-TLE",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2968,
      "y" : 1422
    },
    "minX" : 2916,
    "maxX" : 2995,
    "minY" : 1411,
    "maxY" : 1433,
    "prop" : {
      "x" : 2941,
      "y" : 1411,
      "width" : 54,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2943,
      "y" : 1411
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 74809,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2935,
          "y" : 1419
        },
        "to" : {
          "x" : 2916,
          "y" : 1418
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2928,
          "y" : 1423
        },
        "b" : {
          "x" : 2935,
          "y" : 1419
        },
        "c" : {
          "x" : 2928,
          "y" : 1415
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2928,
          "y" : 1415
        }
      }
    } ]
  }, {
    "id" : 74813,
    "reactomeId" : 10049168,
    "displayName" : "CBY1:CTNNB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2528,
      "y" : 1095
    },
    "minX" : 2467,
    "maxX" : 2596,
    "minY" : 1046,
    "maxY" : 1107,
    "prop" : {
      "x" : 2467,
      "y" : 1084,
      "width" : 123,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2482,
      "y" : 1086
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2590,
          "y" : 1084
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2590,
          "y" : 1084
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74811,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74814,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2528,
          "y" : 1081
        },
        "to" : {
          "x" : 2530,
          "y" : 1046
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74812,
    "reactomeId" : 10049166,
    "displayName" : "Cby1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2555,
      "y" : 1185
    },
    "minX" : 2505,
    "maxX" : 2581,
    "minY" : 1166,
    "maxY" : 1196,
    "prop" : {
      "x" : 2535,
      "y" : 1174,
      "width" : 40,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2536,
      "y" : 1174
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2575,
          "y" : 1174
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2575,
          "y" : 1174
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74811,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2532,
          "y" : 1177
        },
        "to" : {
          "x" : 2505,
          "y" : 1166
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74815,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2586,
      "y" : 1061
    },
    "minX" : 2530,
    "maxX" : 2606,
    "minY" : 1045,
    "maxY" : 1076,
    "prop" : {
      "x" : 2567,
      "y" : 1046,
      "width" : 38,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2570,
      "y" : 1050
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2600,
          "y" : 1051
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2600,
          "y" : 1051
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74814,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2564,
          "y" : 1055
        },
        "to" : {
          "x" : 2530,
          "y" : 1046
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74817,
    "reactomeId" : 10049175,
    "displayName" : "pS20-CBY1:CTNNB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2530,
      "y" : 940
    },
    "minX" : 2468,
    "maxX" : 2599,
    "minY" : 889,
    "maxY" : 992,
    "prop" : {
      "x" : 2468,
      "y" : 924,
      "width" : 125,
      "height" : 32
    },
    "textPosition" : {
      "x" : 2491,
      "y" : 921
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2593,
          "y" : 924
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2593,
          "y" : 924
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74814,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2531,
          "y" : 959
        },
        "to" : {
          "x" : 2535,
          "y" : 992
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2536,
          "y" : 965
        },
        "b" : {
          "x" : 2531,
          "y" : 959
        },
        "c" : {
          "x" : 2528,
          "y" : 966
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2528,
          "y" : 966
        }
      }
    }, {
      "edgeId" : 74819,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2532,
          "y" : 921
        },
        "to" : {
          "x" : 2537,
          "y" : 889
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74816,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2584,
      "y" : 981
    },
    "minX" : 2535,
    "maxX" : 2605,
    "minY" : 965,
    "maxY" : 996,
    "prop" : {
      "x" : 2565,
      "y" : 966,
      "width" : 39,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2568,
      "y" : 970
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2599,
          "y" : 971
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2599,
          "y" : 971
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74814,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2562,
          "y" : 985
        },
        "to" : {
          "x" : 2535,
          "y" : 992
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2556,
          "y" : 991
        },
        "b" : {
          "x" : 2562,
          "y" : 985
        },
        "c" : {
          "x" : 2554,
          "y" : 983
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2554,
          "y" : 983
        }
      }
    } ]
  }, {
    "id" : 74818,
    "reactomeId" : 10049191,
    "displayName" : "p-AKT1/2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2462,
      "y" : 1001
    },
    "minX" : 2421,
    "maxX" : 2529,
    "minY" : 987,
    "maxY" : 1023,
    "prop" : {
      "x" : 2421,
      "y" : 987,
      "width" : 82,
      "height" : 28
    },
    "textPosition" : {
      "x" : 2431,
      "y" : 990
    },
    "connectors" : [ {
      "edgeId" : 74814,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2509,
          "y" : 1013
        },
        "to" : {
          "x" : 2521,
          "y" : 1018
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2525,
          "y" : 1019
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2525,
          "y" : 1019
        }
      }
    } ]
  }, {
    "id" : 74821,
    "reactomeId" : 10049177,
    "displayName" : "YWHAZ:p-S20-CBY:CTNNB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2599,
      "y" : 841
    },
    "minX" : 2538,
    "maxX" : 2715,
    "minY" : 817,
    "maxY" : 859,
    "prop" : {
      "x" : 2538,
      "y" : 823,
      "width" : 123,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2538,
      "y" : 824
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2661,
          "y" : 823
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2661,
          "y" : 823
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74819,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74822,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2664,
          "y" : 836
        },
        "to" : {
          "x" : 2715,
          "y" : 832
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74820,
    "reactomeId" : 10018927,
    "displayName" : "Ywhaz",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2484,
      "y" : 892
    },
    "minX" : 2453,
    "maxX" : 2537,
    "minY" : 875,
    "maxY" : 904,
    "prop" : {
      "x" : 2453,
      "y" : 881,
      "width" : 63,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2462,
      "y" : 882
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2516,
          "y" : 881
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2516,
          "y" : 881
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74819,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2519,
          "y" : 890
        },
        "to" : {
          "x" : 2537,
          "y" : 889
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74823,
    "reactomeId" : 9769779,
    "displayName" : "Xpo1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2719,
      "y" : 874
    },
    "minX" : 2687,
    "maxX" : 2757,
    "minY" : 832,
    "maxY" : 885,
    "prop" : {
      "x" : 2687,
      "y" : 863,
      "width" : 64,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2699,
      "y" : 863
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2751,
          "y" : 863
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2751,
          "y" : 863
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74822,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2717,
          "y" : 860
        },
        "to" : {
          "x" : 2715,
          "y" : 832
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74824,
    "reactomeId" : 10049179,
    "displayName" : "XPO1:YWHAZ:p-S20-CBY1:CTNNB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2859,
      "y" : 829
    },
    "minX" : 2795,
    "maxX" : 2930,
    "minY" : 805,
    "maxY" : 847,
    "prop" : {
      "x" : 2795,
      "y" : 811,
      "width" : 129,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2799,
      "y" : 812
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2924,
          "y" : 811
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2924,
          "y" : 811
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74822,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74825,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74826,
    "reactomeId" : 10049185,
    "displayName" : "XPO1:YWHAZ:p-S20-CBY1:CTNNB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2846,
      "y" : 637
    },
    "minX" : 2800,
    "maxX" : 2899,
    "minY" : 603,
    "maxY" : 666,
    "prop" : {
      "x" : 2800,
      "y" : 609,
      "width" : 93,
      "height" : 57
    },
    "textPosition" : {
      "x" : 2800,
      "y" : 617
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2893,
          "y" : 609
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2893,
          "y" : 609
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74825,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74829,
    "reactomeId" : 10049216,
    "displayName" : "DKK",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 504,
      "y" : 343
    },
    "minX" : 472,
    "maxX" : 581,
    "minY" : 334,
    "maxY" : 369,
    "prop" : {
      "x" : 472,
      "y" : 334,
      "width" : 65,
      "height" : 19
    },
    "textPosition" : {
      "x" : 489,
      "y" : 333
    },
    "connectors" : [ {
      "edgeId" : 74827,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 532,
          "y" : 359
        },
        "to" : {
          "x" : 581,
          "y" : 369
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74828,
    "reactomeId" : 10003935,
    "displayName" : "LRP5/6",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 360,
      "y" : 388
    },
    "minX" : 329,
    "maxX" : 581,
    "minY" : 291,
    "maxY" : 402,
    "prop" : {
      "x" : 329,
      "y" : 375,
      "width" : 63,
      "height" : 27
    },
    "textPosition" : {
      "x" : 335,
      "y" : 378
    },
    "connectors" : [ {
      "edgeId" : 74827,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 398,
          "y" : 385
        },
        "to" : {
          "x" : 581,
          "y" : 369
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74832,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 381,
          "y" : 369
        },
        "to" : {
          "x" : 514,
          "y" : 291
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74831,
    "reactomeId" : 10049228,
    "displayName" : "KRM:DKK:LRP5/6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 609,
      "y" : 476
    },
    "minX" : 560,
    "maxX" : 664,
    "minY" : 452,
    "maxY" : 494,
    "prop" : {
      "x" : 560,
      "y" : 458,
      "width" : 98,
      "height" : 36
    },
    "textPosition" : {
      "x" : 577,
      "y" : 459
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 658,
          "y" : 458
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 658,
          "y" : 458
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74913,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74827,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74830,
    "reactomeId" : 10049226,
    "displayName" : "KRM1/2",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 520,
      "y" : 407
    },
    "minX" : 487,
    "maxX" : 581,
    "minY" : 369,
    "maxY" : 418,
    "prop" : {
      "x" : 487,
      "y" : 396,
      "width" : 67,
      "height" : 22
    },
    "textPosition" : {
      "x" : 494,
      "y" : 396
    },
    "connectors" : [ {
      "edgeId" : 74827,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 537,
          "y" : 390
        },
        "to" : {
          "x" : 581,
          "y" : 369
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74833,
    "reactomeId" : 10049198,
    "displayName" : "Sost",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 455,
      "y" : 283
    },
    "minX" : 435,
    "maxX" : 514,
    "minY" : 266,
    "maxY" : 294,
    "prop" : {
      "x" : 435,
      "y" : 272,
      "width" : 41,
      "height" : 22
    },
    "textPosition" : {
      "x" : 437,
      "y" : 272
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 476,
          "y" : 272
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 476,
          "y" : 272
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74832,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 479,
          "y" : 285
        },
        "to" : {
          "x" : 514,
          "y" : 291
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74834,
    "reactomeId" : 10049200,
    "displayName" : "SOST:LRP5/6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 646,
      "y" : 359
    },
    "minX" : 607,
    "maxX" : 692,
    "minY" : 335,
    "maxY" : 378,
    "prop" : {
      "x" : 607,
      "y" : 341,
      "width" : 79,
      "height" : 37
    },
    "textPosition" : {
      "x" : 621,
      "y" : 343
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 686,
          "y" : 341
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 686,
          "y" : 341
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74832,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74837,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 928,
      "y" : 749
    },
    "minX" : 911,
    "maxX" : 947,
    "minY" : 713,
    "maxY" : 764,
    "prop" : {
      "x" : 911,
      "y" : 734,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 913,
      "y" : 738
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 941,
          "y" : 739
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 941,
          "y" : 739
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74835,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 930,
          "y" : 731
        },
        "to" : {
          "x" : 934,
          "y" : 713
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74836,
    "reactomeId" : 10004076,
    "displayName" : "p-DVL",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 878,
      "y" : 717
    },
    "minX" : 807,
    "maxX" : 934,
    "minY" : 707,
    "maxY" : 727,
    "prop" : {
      "x" : 849,
      "y" : 707,
      "width" : 59,
      "height" : 20
    },
    "textPosition" : {
      "x" : 857,
      "y" : 707
    },
    "connectors" : [ {
      "edgeId" : 74835,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 914,
          "y" : 714
        },
        "to" : {
          "x" : 934,
          "y" : 713
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74849,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 843,
          "y" : 717
        },
        "to" : {
          "x" : 807,
          "y" : 717
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 836,
          "y" : 721
        },
        "b" : {
          "x" : 843,
          "y" : 717
        },
        "c" : {
          "x" : 836,
          "y" : 713
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 836,
          "y" : 713
        }
      }
    } ]
  }, {
    "id" : 74839,
    "reactomeId" : 10003985,
    "displayName" : "pp-DVL",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1079,
      "y" : 714
    },
    "minX" : 983,
    "maxX" : 1155,
    "minY" : 701,
    "maxY" : 728,
    "prop" : {
      "x" : 1031,
      "y" : 701,
      "width" : 96,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1053,
      "y" : 704
    },
    "connectors" : [ {
      "edgeId" : 74835,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1025,
          "y" : 714
        },
        "to" : {
          "x" : 983,
          "y" : 714
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1018,
          "y" : 718
        },
        "b" : {
          "x" : 1025,
          "y" : 714
        },
        "c" : {
          "x" : 1018,
          "y" : 710
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1018,
          "y" : 710
        }
      }
    }, {
      "edgeId" : 74841,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1133,
          "y" : 714
        },
        "to" : {
          "x" : 1155,
          "y" : 714
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74838,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1014,
      "y" : 750
    },
    "minX" : 983,
    "maxX" : 1036,
    "minY" : 714,
    "maxY" : 765,
    "prop" : {
      "x" : 994,
      "y" : 735,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 998,
      "y" : 739
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1030,
          "y" : 740
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1030,
          "y" : 740
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74835,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1001,
          "y" : 732
        },
        "to" : {
          "x" : 983,
          "y" : 714
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 993,
          "y" : 730
        },
        "b" : {
          "x" : 1001,
          "y" : 732
        },
        "c" : {
          "x" : 999,
          "y" : 724
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 999,
          "y" : 724
        }
      }
    } ]
  }, {
    "id" : 74840,
    "reactomeId" : 10011691,
    "displayName" : "CSNK1E",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 962,
      "y" : 791
    },
    "minX" : 934,
    "maxX" : 997,
    "minY" : 723,
    "maxY" : 802,
    "prop" : {
      "x" : 934,
      "y" : 780,
      "width" : 57,
      "height" : 22
    },
    "textPosition" : {
      "x" : 934,
      "y" : 780
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 991,
          "y" : 780
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 991,
          "y" : 780
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74835,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 962,
          "y" : 777
        },
        "to" : {
          "x" : 962,
          "y" : 731
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 962,
          "y" : 727
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 962,
          "y" : 727
        }
      }
    } ]
  }, {
    "id" : 74843,
    "reactomeId" : 10049240,
    "displayName" : "ppDVL:PIP5K1B",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1247,
      "y" : 717
    },
    "minX" : 1204,
    "maxX" : 1297,
    "minY" : 465,
    "maxY" : 738,
    "prop" : {
      "x" : 1204,
      "y" : 697,
      "width" : 87,
      "height" : 41
    },
    "textPosition" : {
      "x" : 1218,
      "y" : 703
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1291,
          "y" : 697
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1291,
          "y" : 697
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74841,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74844,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1245,
          "y" : 694
        },
        "to" : {
          "x" : 1234,
          "y" : 473
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1234,
          "y" : 469
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1234,
          "y" : 469
        }
      }
    } ]
  }, {
    "id" : 74842,
    "reactomeId" : 10035792,
    "displayName" : "Pip5k1b",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1124,
      "y" : 786
    },
    "minX" : 1080,
    "maxX" : 1174,
    "minY" : 714,
    "maxY" : 800,
    "prop" : {
      "x" : 1080,
      "y" : 772,
      "width" : 88,
      "height" : 28
    },
    "textPosition" : {
      "x" : 1095,
      "y" : 775
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1168,
          "y" : 772
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1168,
          "y" : 772
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74841,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1130,
          "y" : 769
        },
        "to" : {
          "x" : 1155,
          "y" : 714
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74845,
    "reactomeId" : 392417,
    "displayName" : "PI4P",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1128,
      "y" : 460
    },
    "minX" : 1097,
    "maxX" : 1198,
    "minY" : 444,
    "maxY" : 476,
    "prop" : {
      "x" : 1097,
      "y" : 445,
      "width" : 62,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1110,
      "y" : 450
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1154,
          "y" : 450
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1154,
          "y" : 450
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74844,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1162,
          "y" : 458
        },
        "to" : {
          "x" : 1198,
          "y" : 456
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74847,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1292,
      "y" : 501
    },
    "minX" : 1258,
    "maxX" : 1327,
    "minY" : 455,
    "maxY" : 514,
    "prop" : {
      "x" : 1258,
      "y" : 488,
      "width" : 68,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1275,
      "y" : 490
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1321,
          "y" : 493
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1321,
          "y" : 493
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74844,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1283,
          "y" : 485
        },
        "to" : {
          "x" : 1262,
          "y" : 455
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1276,
          "y" : 482
        },
        "b" : {
          "x" : 1283,
          "y" : 485
        },
        "c" : {
          "x" : 1282,
          "y" : 477
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1282,
          "y" : 477
        }
      }
    } ]
  }, {
    "id" : 74846,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1165,
      "y" : 492
    },
    "minX" : 1138,
    "maxX" : 1198,
    "minY" : 456,
    "maxY" : 505,
    "prop" : {
      "x" : 1138,
      "y" : 480,
      "width" : 54,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1149,
      "y" : 482
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1187,
          "y" : 485
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1187,
          "y" : 485
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74844,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1176,
          "y" : 477
        },
        "to" : {
          "x" : 1198,
          "y" : 456
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74848,
    "reactomeId" : 179856,
    "displayName" : "PI(4,5)P2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1357,
      "y" : 464
    },
    "minX" : 1262,
    "maxX" : 1394,
    "minY" : 448,
    "maxY" : 479,
    "prop" : {
      "x" : 1321,
      "y" : 449,
      "width" : 72,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1324,
      "y" : 453
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1388,
          "y" : 454
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1388,
          "y" : 454
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74844,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1318,
          "y" : 460
        },
        "to" : {
          "x" : 1262,
          "y" : 455
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1311,
          "y" : 463
        },
        "b" : {
          "x" : 1318,
          "y" : 460
        },
        "c" : {
          "x" : 1311,
          "y" : 455
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1311,
          "y" : 455
        }
      }
    } ]
  }, {
    "id" : 74851,
    "reactomeId" : 10004067,
    "displayName" : "DVL",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 682,
      "y" : 717
    },
    "minX" : 659,
    "maxX" : 762,
    "minY" : 708,
    "maxY" : 727,
    "prop" : {
      "x" : 659,
      "y" : 708,
      "width" : 47,
      "height" : 19
    },
    "textPosition" : {
      "x" : 667,
      "y" : 707
    },
    "connectors" : [ {
      "edgeId" : 74849,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 712,
          "y" : 717
        },
        "to" : {
          "x" : 762,
          "y" : 718
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74850,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 735,
      "y" : 752
    },
    "minX" : 714,
    "maxX" : 762,
    "minY" : 718,
    "maxY" : 766,
    "prop" : {
      "x" : 714,
      "y" : 739,
      "width" : 43,
      "height" : 27
    },
    "textPosition" : {
      "x" : 720,
      "y" : 742
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 752,
          "y" : 744
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 752,
          "y" : 744
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74849,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 745,
          "y" : 736
        },
        "to" : {
          "x" : 762,
          "y" : 718
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74853,
    "reactomeId" : 10004095,
    "displayName" : "Casein kinase II",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 789,
      "y" : 795
    },
    "minX" : 735,
    "maxX" : 849,
    "minY" : 727,
    "maxY" : 808,
    "prop" : {
      "x" : 735,
      "y" : 782,
      "width" : 108,
      "height" : 26
    },
    "textPosition" : {
      "x" : 736,
      "y" : 787
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 843,
          "y" : 782
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 843,
          "y" : 782
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74849,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 788,
          "y" : 779
        },
        "to" : {
          "x" : 787,
          "y" : 735
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 786,
          "y" : 731
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 786,
          "y" : 731
        }
      }
    } ]
  }, {
    "id" : 74852,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 847,
      "y" : 749
    },
    "minX" : 807,
    "maxX" : 871,
    "minY" : 717,
    "maxY" : 762,
    "prop" : {
      "x" : 825,
      "y" : 736,
      "width" : 45,
      "height" : 26
    },
    "textPosition" : {
      "x" : 831,
      "y" : 738
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 865,
          "y" : 741
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 865,
          "y" : 741
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74849,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 830,
          "y" : 733
        },
        "to" : {
          "x" : 807,
          "y" : 717
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 822,
          "y" : 732
        },
        "b" : {
          "x" : 830,
          "y" : 733
        },
        "c" : {
          "x" : 827,
          "y" : 726
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 827,
          "y" : 726
        }
      }
    } ]
  }, {
    "id" : 74855,
    "reactomeId" : 10049234,
    "displayName" : "Ctnnbip1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2350,
      "y" : 1183
    },
    "minX" : 2316,
    "maxX" : 2390,
    "minY" : 1153,
    "maxY" : 1194,
    "prop" : {
      "x" : 2316,
      "y" : 1172,
      "width" : 68,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2318,
      "y" : 1172
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2384,
          "y" : 1172
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2384,
          "y" : 1172
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74854,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2358,
          "y" : 1169
        },
        "to" : {
          "x" : 2374,
          "y" : 1153
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74856,
    "reactomeId" : 10049236,
    "displayName" : "CTNNBIP1:CTNNB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2281,
      "y" : 1078
    },
    "minX" : 2227,
    "maxX" : 2342,
    "minY" : 1052,
    "maxY" : 1099,
    "prop" : {
      "x" : 2227,
      "y" : 1058,
      "width" : 109,
      "height" : 41
    },
    "textPosition" : {
      "x" : 2245,
      "y" : 1064
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2336,
          "y" : 1058
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2336,
          "y" : 1058
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74854,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74859,
    "reactomeId" : 10049133,
    "displayName" : "Usp34",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1439,
      "y" : 1917
    },
    "minX" : 1414,
    "maxX" : 1470,
    "minY" : 1870,
    "maxY" : 1928,
    "prop" : {
      "x" : 1414,
      "y" : 1906,
      "width" : 50,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1415,
      "y" : 1906
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1464,
          "y" : 1906
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1464,
          "y" : 1906
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74857,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1435,
          "y" : 1903
        },
        "to" : {
          "x" : 1428,
          "y" : 1878
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1426,
          "y" : 1874
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1426,
          "y" : 1874
        }
      }
    } ]
  }, {
    "id" : 74858,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1534,
      "y" : 1896
    },
    "minX" : 1469,
    "maxX" : 1557,
    "minY" : 1855,
    "maxY" : 1911,
    "prop" : {
      "x" : 1513,
      "y" : 1881,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1517,
      "y" : 1885
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1551,
          "y" : 1886
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1551,
          "y" : 1886
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74857,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1510,
          "y" : 1882
        },
        "to" : {
          "x" : 1469,
          "y" : 1855
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 74861,
    "reactomeId" : 1504179,
    "displayName" : "Dvl1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 540,
      "y" : 1059
    },
    "minX" : 514,
    "maxX" : 572,
    "minY" : 1040,
    "maxY" : 1126,
    "prop" : {
      "x" : 514,
      "y" : 1046,
      "width" : 52,
      "height" : 27
    },
    "textPosition" : {
      "x" : 523,
      "y" : 1049
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 566,
          "y" : 1046
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 566,
          "y" : 1046
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74860,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 541,
          "y" : 1076
        },
        "to" : {
          "x" : 546,
          "y" : 1126
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74863,
    "reactomeId" : 10051157,
    "displayName" : "DVL1:HECW1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 548,
      "y" : 1192
    },
    "minX" : 502,
    "maxX" : 600,
    "minY" : 1168,
    "maxY" : 1295,
    "prop" : {
      "x" : 502,
      "y" : 1174,
      "width" : 92,
      "height" : 36
    },
    "textPosition" : {
      "x" : 504,
      "y" : 1189
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 594,
          "y" : 1174
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 594,
          "y" : 1174
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74860,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74864,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 548,
          "y" : 1213
        },
        "to" : {
          "x" : 548,
          "y" : 1263
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74864,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 537,
          "y" : 1213
        },
        "to" : {
          "x" : 518,
          "y" : 1244
        }
      }, {
        "from" : {
          "x" : 518,
          "y" : 1244
        },
        "to" : {
          "x" : 544,
          "y" : 1287
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 546,
          "y" : 1291
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 546,
          "y" : 1291
        }
      }
    } ]
  }, {
    "id" : 74862,
    "reactomeId" : 10051155,
    "displayName" : "Hecw1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 642,
      "y" : 1082
    },
    "minX" : 546,
    "maxX" : 677,
    "minY" : 1061,
    "maxY" : 1308,
    "prop" : {
      "x" : 614,
      "y" : 1067,
      "width" : 57,
      "height" : 30
    },
    "textPosition" : {
      "x" : 618,
      "y" : 1071
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 671,
          "y" : 1067
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 671,
          "y" : 1067
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74860,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 611,
          "y" : 1095
        },
        "to" : {
          "x" : 546,
          "y" : 1126
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74867,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 642,
          "y" : 1100
        },
        "to" : {
          "x" : 655,
          "y" : 1308
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 646,
          "y" : 1107
        },
        "b" : {
          "x" : 642,
          "y" : 1100
        },
        "c" : {
          "x" : 638,
          "y" : 1107
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 638,
          "y" : 1107
        }
      }
    } ]
  }, {
    "id" : 74865,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 598,
      "y" : 1265
    },
    "minX" : 548,
    "maxX" : 655,
    "minY" : 1251,
    "maxY" : 1308,
    "prop" : {
      "x" : 572,
      "y" : 1251,
      "width" : 53,
      "height" : 28
    },
    "textPosition" : {
      "x" : 586,
      "y" : 1254
    },
    "connectors" : [ {
      "edgeId" : 74864,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 566,
          "y" : 1263
        },
        "to" : {
          "x" : 548,
          "y" : 1263
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74867,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 616,
          "y" : 1285
        },
        "to" : {
          "x" : 655,
          "y" : 1308
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 624,
          "y" : 1285
        },
        "b" : {
          "x" : 616,
          "y" : 1285
        },
        "c" : {
          "x" : 620,
          "y" : 1292
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 620,
          "y" : 1292
        }
      }
    } ]
  }, {
    "id" : 74866,
    "reactomeId" : 10051161,
    "displayName" : "ub-DVL1:HECW1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 553,
      "y" : 1355
    },
    "minX" : 506,
    "maxX" : 606,
    "minY" : 1331,
    "maxY" : 1374,
    "prop" : {
      "x" : 506,
      "y" : 1337,
      "width" : 94,
      "height" : 37
    },
    "textPosition" : {
      "x" : 521,
      "y" : 1339
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 600,
          "y" : 1337
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 600,
          "y" : 1337
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74864,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74867,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74869,
    "reactomeId" : 10051147,
    "displayName" : "Dact1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1260,
      "y" : 883
    },
    "minX" : 1221,
    "maxX" : 1297,
    "minY" : 865,
    "maxY" : 936,
    "prop" : {
      "x" : 1229,
      "y" : 871,
      "width" : 62,
      "height" : 24
    },
    "textPosition" : {
      "x" : 1237,
      "y" : 872
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1291,
          "y" : 871
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1291,
          "y" : 871
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74868,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1251,
          "y" : 898
        },
        "to" : {
          "x" : 1221,
          "y" : 936
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74871,
    "reactomeId" : 10051149,
    "displayName" : "DVL2:DACT1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1220,
      "y" : 1022
    },
    "minX" : 1170,
    "maxX" : 1276,
    "minY" : 1001,
    "maxY" : 1037,
    "prop" : {
      "x" : 1170,
      "y" : 1007,
      "width" : 100,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1178,
      "y" : 1016
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1270,
          "y" : 1007
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1270,
          "y" : 1007
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74868,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74870,
    "reactomeId" : 10004063,
    "displayName" : "Dvl2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1179,
      "y" : 883
    },
    "minX" : 1152,
    "maxX" : 1221,
    "minY" : 866,
    "maxY" : 936,
    "prop" : {
      "x" : 1152,
      "y" : 872,
      "width" : 55,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1162,
      "y" : 872
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1207,
          "y" : 872
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1207,
          "y" : 872
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74868,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1187,
          "y" : 897
        },
        "to" : {
          "x" : 1221,
          "y" : 936
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74873,
    "reactomeId" : 5632468,
    "displayName" : "Smurf2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 599,
      "y" : 1570
    },
    "minX" : 570,
    "maxX" : 844,
    "minY" : 1487,
    "maxY" : 1581,
    "prop" : {
      "x" : 570,
      "y" : 1559,
      "width" : 59,
      "height" : 22
    },
    "textPosition" : {
      "x" : 573,
      "y" : 1559
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 629,
          "y" : 1559
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 629,
          "y" : 1559
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74872,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 632,
          "y" : 1570
        },
        "to" : {
          "x" : 693,
          "y" : 1573
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74878,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 632,
          "y" : 1560
        },
        "to" : {
          "x" : 844,
          "y" : 1487
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 637,
          "y" : 1554
        },
        "b" : {
          "x" : 632,
          "y" : 1560
        },
        "c" : {
          "x" : 640,
          "y" : 1562
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 640,
          "y" : 1562
        }
      }
    } ]
  }, {
    "id" : 74874,
    "reactomeId" : 10051128,
    "displayName" : "AXIN:SMURF2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 808,
      "y" : 1578
    },
    "minX" : 771,
    "maxX" : 914,
    "minY" : 1554,
    "maxY" : 1616,
    "prop" : {
      "x" : 771,
      "y" : 1560,
      "width" : 74,
      "height" : 37
    },
    "textPosition" : {
      "x" : 779,
      "y" : 1562
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 845,
          "y" : 1560
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 845,
          "y" : 1560
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74872,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74875,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 848,
          "y" : 1575
        },
        "to" : {
          "x" : 886,
          "y" : 1573
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74875,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 848,
          "y" : 1596
        },
        "to" : {
          "x" : 884,
          "y" : 1616
        }
      }, {
        "from" : {
          "x" : 884,
          "y" : 1616
        },
        "to" : {
          "x" : 908,
          "y" : 1587
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 910,
          "y" : 1584
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 910,
          "y" : 1584
        }
      }
    } ]
  }, {
    "id" : 74877,
    "reactomeId" : 10051138,
    "displayName" : "ub-AXIN:SMURF2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1002,
      "y" : 1575
    },
    "minX" : 950,
    "maxX" : 1060,
    "minY" : 1548,
    "maxY" : 1596,
    "prop" : {
      "x" : 950,
      "y" : 1554,
      "width" : 104,
      "height" : 42
    },
    "textPosition" : {
      "x" : 972,
      "y" : 1561
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1054,
          "y" : 1554
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1054,
          "y" : 1554
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74875,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74878,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74876,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 839,
      "y" : 1529
    },
    "minX" : 801,
    "maxX" : 886,
    "minY" : 1487,
    "maxY" : 1573,
    "prop" : {
      "x" : 801,
      "y" : 1518,
      "width" : 76,
      "height" : 22
    },
    "textPosition" : {
      "x" : 826,
      "y" : 1518
    },
    "connectors" : [ {
      "edgeId" : 74875,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 850,
          "y" : 1546
        },
        "to" : {
          "x" : 886,
          "y" : 1573
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74878,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 840,
          "y" : 1512
        },
        "to" : {
          "x" : 844,
          "y" : 1487
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 837,
          "y" : 1505
        },
        "b" : {
          "x" : 840,
          "y" : 1512
        },
        "c" : {
          "x" : 845,
          "y" : 1506
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 845,
          "y" : 1506
        }
      }
    } ]
  }, {
    "id" : 74881,
    "reactomeId" : 10051204,
    "displayName" : "ZNRF3,RNF43",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 134,
      "y" : 1071
    },
    "minX" : 75,
    "maxX" : 298,
    "minY" : 861,
    "maxY" : 1275,
    "prop" : {
      "x" : 75,
      "y" : 1055,
      "width" : 118,
      "height" : 32
    },
    "textPosition" : {
      "x" : 87,
      "y" : 1060
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 204
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 74894,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 143,
          "y" : 1049
        },
        "to" : {
          "x" : 258,
          "y" : 861
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74879,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 137,
          "y" : 1093
        },
        "to" : {
          "x" : 181,
          "y" : 1266
        }
      }, {
        "from" : {
          "x" : 181,
          "y" : 1266
        },
        "to" : {
          "x" : 298,
          "y" : 1275
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74880,
    "reactomeId" : 10051237,
    "displayName" : "N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 298,
      "y" : 1228
    },
    "minX" : 235,
    "maxX" : 367,
    "minY" : 1169,
    "maxY" : 1275,
    "prop" : {
      "x" : 235,
      "y" : 1203,
      "width" : 126,
      "height" : 50
    },
    "textPosition" : {
      "x" : 235,
      "y" : 1204
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 361,
          "y" : 1203
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 361,
          "y" : 1203
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74886,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 296,
          "y" : 1200
        },
        "to" : {
          "x" : 295,
          "y" : 1169
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 292,
          "y" : 1193
        },
        "b" : {
          "x" : 296,
          "y" : 1200
        },
        "c" : {
          "x" : 300,
          "y" : 1193
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 300,
          "y" : 1193
        }
      }
    }, {
      "edgeId" : 74879,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 298,
          "y" : 1256
        },
        "to" : {
          "x" : 298,
          "y" : 1275
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74882,
    "reactomeId" : 10051255,
    "displayName" : "N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 296,
      "y" : 1353
    },
    "minX" : 233,
    "maxX" : 366,
    "minY" : 1314,
    "maxY" : 1431,
    "prop" : {
      "x" : 233,
      "y" : 1320,
      "width" : 127,
      "height" : 67
    },
    "textPosition" : {
      "x" : 233,
      "y" : 1324
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 360,
          "y" : 1320
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 360,
          "y" : 1320
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74883,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 293,
          "y" : 1390
        },
        "to" : {
          "x" : 292,
          "y" : 1407
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74883,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 269,
          "y" : 1390
        },
        "to" : {
          "x" : 246,
          "y" : 1417
        }
      }, {
        "from" : {
          "x" : 246,
          "y" : 1417
        },
        "to" : {
          "x" : 275,
          "y" : 1425
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 278,
          "y" : 1427
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 278,
          "y" : 1427
        }
      }
    }, {
      "edgeId" : 74879,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74885,
    "reactomeId" : 10051259,
    "displayName" : "N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 295,
      "y" : 1500
    },
    "minX" : 234,
    "maxX" : 362,
    "minY" : 1465,
    "maxY" : 1530,
    "prop" : {
      "x" : 234,
      "y" : 1471,
      "width" : 122,
      "height" : 59
    },
    "textPosition" : {
      "x" : 236,
      "y" : 1467
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 356,
          "y" : 1471
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 356,
          "y" : 1471
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74883,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74884,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 417,
      "y" : 1391
    },
    "minX" : 292,
    "maxX" : 457,
    "minY" : 1169,
    "maxY" : 1407,
    "prop" : {
      "x" : 377,
      "y" : 1377,
      "width" : 80,
      "height" : 29
    },
    "textPosition" : {
      "x" : 404,
      "y" : 1381
    },
    "connectors" : [ {
      "edgeId" : 74883,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 371,
          "y" : 1396
        },
        "to" : {
          "x" : 292,
          "y" : 1407
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74886,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 415,
          "y" : 1371
        },
        "to" : {
          "x" : 393,
          "y" : 1204
        }
      }, {
        "from" : {
          "x" : 393,
          "y" : 1204
        },
        "to" : {
          "x" : 295,
          "y" : 1169
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 410,
          "y" : 1365
        },
        "b" : {
          "x" : 415,
          "y" : 1371
        },
        "c" : {
          "x" : 418,
          "y" : 1364
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 418,
          "y" : 1364
        }
      }
    } ]
  }, {
    "id" : 74887,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 379,
      "y" : 1105
    },
    "minX" : 291,
    "maxX" : 402,
    "minY" : 1089,
    "maxY" : 1124,
    "prop" : {
      "x" : 358,
      "y" : 1090,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 362,
      "y" : 1094
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 396,
          "y" : 1095
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 396,
          "y" : 1095
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74886,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 355,
          "y" : 1109
        },
        "to" : {
          "x" : 291,
          "y" : 1124
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 74889,
    "reactomeId" : 10030351,
    "displayName" : "Usp8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 355,
      "y" : 1147
    },
    "minX" : 301,
    "maxX" : 382,
    "minY" : 1130,
    "maxY" : 1158,
    "prop" : {
      "x" : 334,
      "y" : 1136,
      "width" : 42,
      "height" : 22
    },
    "textPosition" : {
      "x" : 335,
      "y" : 1136
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 376,
          "y" : 1136
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 376,
          "y" : 1136
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74886,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 331,
          "y" : 1145
        },
        "to" : {
          "x" : 309,
          "y" : 1144
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 305,
          "y" : 1144
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 305,
          "y" : 1144
        }
      }
    } ]
  }, {
    "id" : 74888,
    "reactomeId" : 10051231,
    "displayName" : "N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 288,
      "y" : 1074
    },
    "minX" : 223,
    "maxX" : 359,
    "minY" : 1043,
    "maxY" : 1124,
    "prop" : {
      "x" : 223,
      "y" : 1049,
      "width" : 130,
      "height" : 50
    },
    "textPosition" : {
      "x" : 224,
      "y" : 1050
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 353,
          "y" : 1049
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 353,
          "y" : 1049
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74886,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 289,
          "y" : 1102
        },
        "to" : {
          "x" : 291,
          "y" : 1124
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74891,
    "reactomeId" : 10051174,
    "displayName" : "LGR",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 231,
      "y" : 753
    },
    "minX" : 200,
    "maxX" : 258,
    "minY" : 738,
    "maxY" : 791,
    "prop" : {
      "x" : 204,
      "y" : 738,
      "width" : 54,
      "height" : 30
    },
    "textPosition" : {
      "x" : 215,
      "y" : 742
    },
    "connectors" : [ {
      "edgeId" : 74890,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 218,
          "y" : 774
        },
        "to" : {
          "x" : 200,
          "y" : 791
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74893,
    "reactomeId" : 10051194,
    "displayName" : "RSPO:LGR",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 193,
      "y" : 862
    },
    "minX" : 153,
    "maxX" : 258,
    "minY" : 841,
    "maxY" : 878,
    "prop" : {
      "x" : 153,
      "y" : 847,
      "width" : 81,
      "height" : 31
    },
    "textPosition" : {
      "x" : 159,
      "y" : 857
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 234,
          "y" : 847
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 234,
          "y" : 847
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74890,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74894,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 237,
          "y" : 861
        },
        "to" : {
          "x" : 258,
          "y" : 861
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74892,
    "reactomeId" : 10051192,
    "displayName" : "RSPO",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 130,
      "y" : 746
    },
    "minX" : 109,
    "maxX" : 200,
    "minY" : 735,
    "maxY" : 791,
    "prop" : {
      "x" : 109,
      "y" : 735,
      "width" : 42,
      "height" : 22
    },
    "textPosition" : {
      "x" : 109,
      "y" : 735
    },
    "connectors" : [ {
      "edgeId" : 74890,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 147,
          "y" : 763
        },
        "to" : {
          "x" : 200,
          "y" : 791
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74895,
    "reactomeId" : 10051206,
    "displayName" : "RSPO:LGR:ZNRF3,RNF43",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 340,
      "y" : 866
    },
    "minX" : 268,
    "maxX" : 394,
    "minY" : 836,
    "maxY" : 942,
    "prop" : {
      "x" : 292,
      "y" : 842,
      "width" : 96,
      "height" : 48
    },
    "textPosition" : {
      "x" : 293,
      "y" : 855
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 388,
          "y" : 842
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 388,
          "y" : 842
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74894,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74896,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 334,
          "y" : 893
        },
        "to" : {
          "x" : 328,
          "y" : 922
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74896,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 306,
          "y" : 893
        },
        "to" : {
          "x" : 268,
          "y" : 918
        }
      }, {
        "from" : {
          "x" : 268,
          "y" : 918
        },
        "to" : {
          "x" : 311,
          "y" : 937
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 315,
          "y" : 938
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 315,
          "y" : 938
        }
      }
    } ]
  }, {
    "id" : 74897,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 431,
      "y" : 908
    },
    "minX" : 328,
    "maxX" : 469,
    "minY" : 897,
    "maxY" : 922,
    "prop" : {
      "x" : 393,
      "y" : 897,
      "width" : 76,
      "height" : 22
    },
    "textPosition" : {
      "x" : 418,
      "y" : 897
    },
    "connectors" : [ {
      "edgeId" : 74896,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 387,
          "y" : 913
        },
        "to" : {
          "x" : 328,
          "y" : 922
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74898,
    "reactomeId" : 10051250,
    "displayName" : "RSPO:LGR:ub-ZNRF3,RNF43",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 326,
      "y" : 996
    },
    "minX" : 279,
    "maxX" : 379,
    "minY" : 972,
    "maxY" : 1014,
    "prop" : {
      "x" : 279,
      "y" : 978,
      "width" : 94,
      "height" : 36
    },
    "textPosition" : {
      "x" : 279,
      "y" : 979
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 373,
          "y" : 978
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 373,
          "y" : 978
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74896,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74901,
    "reactomeId" : 10053777,
    "displayName" : "RYK-binding WNTs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 73,
      "y" : 520
    },
    "minX" : 0,
    "maxX" : 247,
    "minY" : 503,
    "maxY" : 583,
    "prop" : {
      "x" : 0,
      "y" : 503,
      "width" : 146,
      "height" : 34
    },
    "textPosition" : {
      "x" : 14,
      "y" : 509
    },
    "connectors" : [ {
      "edgeId" : 74899,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 119,
          "y" : 543
        },
        "to" : {
          "x" : 247,
          "y" : 583
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74900,
    "reactomeId" : 10053775,
    "displayName" : "RYK",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 252,
      "y" : 507
    },
    "minX" : 213,
    "maxX" : 297,
    "minY" : 483,
    "maxY" : 583,
    "prop" : {
      "x" : 213,
      "y" : 489,
      "width" : 78,
      "height" : 37
    },
    "textPosition" : {
      "x" : 237,
      "y" : 497
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 291,
          "y" : 489
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 291,
          "y" : 489
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74899,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 250,
          "y" : 529
        },
        "to" : {
          "x" : 247,
          "y" : 583
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74902,
    "reactomeId" : 10053779,
    "displayName" : "RYK:WNTs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 252,
      "y" : 667
    },
    "minX" : 197,
    "maxX" : 314,
    "minY" : 645,
    "maxY" : 684,
    "prop" : {
      "x" : 197,
      "y" : 651,
      "width" : 111,
      "height" : 33
    },
    "textPosition" : {
      "x" : 218,
      "y" : 663
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 308,
          "y" : 651
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 308,
          "y" : 651
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74899,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74905,
    "reactomeId" : 10002107,
    "displayName" : "FRAT1,2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1952,
      "y" : 680
    },
    "minX" : 1903,
    "maxX" : 1982,
    "minY" : 669,
    "maxY" : 760,
    "prop" : {
      "x" : 1923,
      "y" : 669,
      "width" : 59,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1923,
      "y" : 669
    },
    "connectors" : [ {
      "edgeId" : 74903,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1945,
          "y" : 697
        },
        "to" : {
          "x" : 1903,
          "y" : 760
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74904,
    "reactomeId" : 10002051,
    "displayName" : "GSK3B",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1847,
      "y" : 690
    },
    "minX" : 1805,
    "maxX" : 1903,
    "minY" : 673,
    "maxY" : 760,
    "prop" : {
      "x" : 1805,
      "y" : 679,
      "width" : 84,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1823,
      "y" : 679
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1889,
          "y" : 679
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1889,
          "y" : 679
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74903,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1855,
          "y" : 704
        },
        "to" : {
          "x" : 1903,
          "y" : 760
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74906,
    "reactomeId" : 10002109,
    "displayName" : "FRAT1,2:GSK3beta",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1905,
      "y" : 837
    },
    "minX" : 1840,
    "maxX" : 1976,
    "minY" : 818,
    "maxY" : 850,
    "prop" : {
      "x" : 1840,
      "y" : 824,
      "width" : 130,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1843,
      "y" : 829
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1970,
          "y" : 824
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1970,
          "y" : 824
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74903,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74909,
    "reactomeId" : 10054531,
    "displayName" : "CTNNB1:CHD8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2280,
      "y" : 863
    },
    "minX" : 2239,
    "maxX" : 2328,
    "minY" : 835,
    "maxY" : 885,
    "prop" : {
      "x" : 2239,
      "y" : 841,
      "width" : 83,
      "height" : 44
    },
    "textPosition" : {
      "x" : 2250,
      "y" : 850
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2322,
          "y" : 841
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2322,
          "y" : 841
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74907,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74908,
    "reactomeId" : 10054529,
    "displayName" : "CHD8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2307,
      "y" : 1011
    },
    "minX" : 2273,
    "maxX" : 2390,
    "minY" : 991,
    "maxY" : 1055,
    "prop" : {
      "x" : 2273,
      "y" : 997,
      "width" : 69,
      "height" : 28
    },
    "textPosition" : {
      "x" : 2286,
      "y" : 1000
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2342,
          "y" : 997
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2342,
          "y" : 997
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74907,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2333,
          "y" : 1028
        },
        "to" : {
          "x" : 2390,
          "y" : 1055
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74911,
    "reactomeId" : 10054559,
    "displayName" : "WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2521,
      "y" : 412
    },
    "minX" : 2463,
    "maxX" : 2585,
    "minY" : 381,
    "maxY" : 437,
    "prop" : {
      "x" : 2463,
      "y" : 387,
      "width" : 116,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2469,
      "y" : 388
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2579,
          "y" : 387
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2579,
          "y" : 387
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74910,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74912,
    "reactomeId" : 10054569,
    "displayName" : "WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2531,
      "y" : 537
    },
    "minX" : 2473,
    "maxX" : 2595,
    "minY" : 506,
    "maxY" : 562,
    "prop" : {
      "x" : 2473,
      "y" : 512,
      "width" : 116,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2479,
      "y" : 513
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2589,
          "y" : 512
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2589,
          "y" : 512
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74910,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74914,
    "reactomeId" : 10054555,
    "displayName" : "KRM:DKK:LRP5/6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 492,
      "y" : 589
    },
    "minX" : 456,
    "maxX" : 534,
    "minY" : 566,
    "maxY" : 607,
    "prop" : {
      "x" : 456,
      "y" : 572,
      "width" : 72,
      "height" : 35
    },
    "textPosition" : {
      "x" : 460,
      "y" : 572
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 528,
          "y" : 572
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 528,
          "y" : 572
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74913,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74917,
    "reactomeId" : 10057041,
    "displayName" : "CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2339,
      "y" : 1354
    },
    "minX" : 2277,
    "maxX" : 2408,
    "minY" : 1323,
    "maxY" : 1379,
    "prop" : {
      "x" : 2277,
      "y" : 1329,
      "width" : 125,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2277,
      "y" : 1330
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2402,
          "y" : 1329
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2402,
          "y" : 1329
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74915,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74916,
    "reactomeId" : 10057039,
    "displayName" : "SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2250,
      "y" : 1244
    },
    "minX" : 2192,
    "maxX" : 2339,
    "minY" : 1219,
    "maxY" : 1269,
    "prop" : {
      "x" : 2192,
      "y" : 1219,
      "width" : 117,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2192,
      "y" : 1219
    },
    "connectors" : [ {
      "edgeId" : 74915,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2315,
          "y" : 1254
        },
        "to" : {
          "x" : 2339,
          "y" : 1260
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74919,
    "reactomeId" : 10058716,
    "displayName" : "SOX4,SOX13,SOX17",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2281,
      "y" : 1412
    },
    "minX" : 2234,
    "maxX" : 2379,
    "minY" : 1396,
    "maxY" : 1453,
    "prop" : {
      "x" : 2234,
      "y" : 1396,
      "width" : 94,
      "height" : 33
    },
    "textPosition" : {
      "x" : 2237,
      "y" : 1395
    },
    "connectors" : [ {
      "edgeId" : 74918,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2320,
          "y" : 1435
        },
        "to" : {
          "x" : 2379,
          "y" : 1453
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74920,
    "reactomeId" : 10058718,
    "displayName" : "TCF/LEF:CTNNB1:SOX4,SOX13,SOX17",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2363,
      "y" : 1551
    },
    "minX" : 2298,
    "maxX" : 2434,
    "minY" : 1527,
    "maxY" : 1569,
    "prop" : {
      "x" : 2298,
      "y" : 1533,
      "width" : 130,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2299,
      "y" : 1534
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2428,
          "y" : 1533
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2428,
          "y" : 1533
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74918,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74923,
    "reactomeId" : 10003967,
    "displayName" : "canonical WNTs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 130,
      "y" : 240
    },
    "minX" : 66,
    "maxX" : 194,
    "minY" : 222,
    "maxY" : 258,
    "prop" : {
      "x" : 66,
      "y" : 222,
      "width" : 128,
      "height" : 36
    },
    "textPosition" : {
      "x" : 77,
      "y" : 229
    },
    "connectors" : [ ]
  }, {
    "id" : 74939,
    "reactomeId" : 10003953,
    "displayName" : "Wnt3a",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 493,
      "y" : 98
    },
    "minX" : 401,
    "maxX" : 591,
    "minY" : 72,
    "maxY" : 118,
    "prop" : {
      "x" : 401,
      "y" : 78,
      "width" : 184,
      "height" : 40
    },
    "textPosition" : {
      "x" : 469,
      "y" : 87
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 585,
          "y" : 78
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 585,
          "y" : 78
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 74938,
    "reactomeId" : 10101013,
    "displayName" : "WNT ligand biogenesis and trafficking",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 281,
      "y" : 48
    },
    "minX" : 188,
    "maxX" : 375,
    "minY" : 0,
    "maxY" : 97,
    "prop" : {
      "x" : 188,
      "y" : 0,
      "width" : 187,
      "height" : 97
    },
    "textPosition" : {
      "x" : 187,
      "y" : 27
    },
    "connectors" : [ ]
  }, {
    "id" : 74942,
    "reactomeId" : 10049107,
    "displayName" : "Axin2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2526,
      "y" : 1939
    },
    "minX" : 2504,
    "maxX" : 2555,
    "minY" : 1922,
    "maxY" : 1950,
    "prop" : {
      "x" : 2504,
      "y" : 1928,
      "width" : 45,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2506,
      "y" : 1928
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2549,
          "y" : 1928
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2549,
          "y" : 1928
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 74945,
    "reactomeId" : 10002081,
    "displayName" : "p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1687,
      "y" : 877
    },
    "minX" : 1617,
    "maxX" : 1763,
    "minY" : 819,
    "maxY" : 929,
    "prop" : {
      "x" : 1617,
      "y" : 825,
      "width" : 140,
      "height" : 104
    },
    "textPosition" : {
      "x" : 1617,
      "y" : 824
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1757,
          "y" : 825
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1757,
          "y" : 825
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 74946,
    "reactomeId" : 10099679,
    "displayName" : "Degradation of beta-catenin by the destruction complex",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1685,
      "y" : 711
    },
    "minX" : 1603,
    "maxX" : 1767,
    "minY" : 668,
    "maxY" : 754,
    "prop" : {
      "x" : 1603,
      "y" : 668,
      "width" : 164,
      "height" : 86
    },
    "textPosition" : {
      "x" : 1611,
      "y" : 682
    },
    "connectors" : [ ]
  }, {
    "id" : 74735,
    "reactomeId" : 10003987,
    "displayName" : "WNT:FZD:LRP5/6:DVL",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1375,
      "y" : 409
    },
    "minX" : 1319,
    "maxX" : 1507,
    "minY" : 378,
    "maxY" : 434,
    "prop" : {
      "x" : 1319,
      "y" : 384,
      "width" : 113,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1337,
      "y" : 399
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1432,
          "y" : 384
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1432,
          "y" : 384
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74734,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1435,
          "y" : 410
        },
        "to" : {
          "x" : 1507,
          "y" : 413
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74737,
    "reactomeId" : 10003989,
    "displayName" : "WNT:FZD:LRP5/6:DVL:AXIN:GSK3B",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1631,
      "y" : 414
    },
    "minX" : 1568,
    "maxX" : 1811,
    "minY" : 373,
    "maxY" : 439,
    "prop" : {
      "x" : 1568,
      "y" : 389,
      "width" : 126,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1574,
      "y" : 404
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1694,
          "y" : 389
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1694,
          "y" : 389
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74757,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1697,
          "y" : 416
        },
        "to" : {
          "x" : 1768,
          "y" : 420
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74757,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1697,
          "y" : 391
        },
        "to" : {
          "x" : 1744,
          "y" : 373
        }
      }, {
        "from" : {
          "x" : 1744,
          "y" : 373
        },
        "to" : {
          "x" : 1803,
          "y" : 410
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1807,
          "y" : 413
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1807,
          "y" : 413
        }
      }
    }, {
      "edgeId" : 74734,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74736,
    "reactomeId" : 10003925,
    "displayName" : "GSK3B:AXIN1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1488,
      "y" : 507
    },
    "minX" : 1443,
    "maxX" : 1682,
    "minY" : 413,
    "maxY" : 1196,
    "prop" : {
      "x" : 1443,
      "y" : 489,
      "width" : 91,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1445,
      "y" : 504
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1534,
          "y" : 489
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1534,
          "y" : 489
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74734,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1491,
          "y" : 486
        },
        "to" : {
          "x" : 1507,
          "y" : 413
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74750,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1490,
          "y" : 528
        },
        "to" : {
          "x" : 1558,
          "y" : 1118
        }
      }, {
        "from" : {
          "x" : 1558,
          "y" : 1118
        },
        "to" : {
          "x" : 1682,
          "y" : 1196
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1495,
          "y" : 534
        },
        "b" : {
          "x" : 1490,
          "y" : 528
        },
        "c" : {
          "x" : 1487,
          "y" : 535
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1487,
          "y" : 535
        }
      }
    } ]
  }, {
    "id" : 74739,
    "reactomeId" : 10033698,
    "displayName" : "CUL3:KLHL12:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 954,
      "y" : 1100
    },
    "minX" : 824,
    "maxX" : 1017,
    "minY" : 1065,
    "maxY" : 1281,
    "prop" : {
      "x" : 898,
      "y" : 1075,
      "width" : 113,
      "height" : 50
    },
    "textPosition" : {
      "x" : 909,
      "y" : 1090
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1011,
          "y" : 1075
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1011,
          "y" : 1075
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74738,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 895,
          "y" : 1084
        },
        "to" : {
          "x" : 824,
          "y" : 1065
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74748,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 954,
          "y" : 1128
        },
        "to" : {
          "x" : 960,
          "y" : 1281
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 958,
          "y" : 1135
        },
        "b" : {
          "x" : 954,
          "y" : 1128
        },
        "c" : {
          "x" : 950,
          "y" : 1135
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 950,
          "y" : 1135
        }
      }
    } ]
  }, {
    "id" : 74741,
    "reactomeId" : 10033702,
    "displayName" : "DVL:CUL3:KLHL12:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 827,
      "y" : 1136
    },
    "minX" : 767,
    "maxX" : 893,
    "minY" : 1112,
    "maxY" : 1213,
    "prop" : {
      "x" : 768,
      "y" : 1118,
      "width" : 119,
      "height" : 36
    },
    "textPosition" : {
      "x" : 768,
      "y" : 1119
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 887,
          "y" : 1118
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 887,
          "y" : 1118
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74738,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74745,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 828,
          "y" : 1157
        },
        "to" : {
          "x" : 830,
          "y" : 1184
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74745,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 804,
          "y" : 1157
        },
        "to" : {
          "x" : 767,
          "y" : 1185
        }
      }, {
        "from" : {
          "x" : 767,
          "y" : 1185
        },
        "to" : {
          "x" : 815,
          "y" : 1207
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 819,
          "y" : 1209
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 819,
          "y" : 1209
        }
      }
    } ]
  }, {
    "id" : 74740,
    "reactomeId" : 10033700,
    "displayName" : "DVL",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 823,
      "y" : 1027
    },
    "minX" : 782,
    "maxX" : 865,
    "minY" : 1016,
    "maxY" : 1065,
    "prop" : {
      "x" : 782,
      "y" : 1016,
      "width" : 83,
      "height" : 22
    },
    "textPosition" : {
      "x" : 808,
      "y" : 1016
    },
    "connectors" : [ {
      "edgeId" : 74738,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 823,
          "y" : 1044
        },
        "to" : {
          "x" : 824,
          "y" : 1065
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74743,
    "reactomeId" : 10002124,
    "displayName" : "Ctnnb1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1777,
      "y" : 1186
    },
    "minX" : 1682,
    "maxX" : 1823,
    "minY" : 1168,
    "maxY" : 1199,
    "prop" : {
      "x" : 1738,
      "y" : 1174,
      "width" : 79,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1751,
      "y" : 1176
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1817,
          "y" : 1174
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1817,
          "y" : 1174
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74742,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74750,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1735,
          "y" : 1190
        },
        "to" : {
          "x" : 1682,
          "y" : 1196
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1729,
          "y" : 1195
        },
        "b" : {
          "x" : 1735,
          "y" : 1190
        },
        "c" : {
          "x" : 1728,
          "y" : 1187
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1728,
          "y" : 1187
        }
      }
    } ]
  }, {
    "id" : 74744,
    "reactomeId" : 10003921,
    "displayName" : "Ctnnb1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2496,
      "y" : 1215
    },
    "minX" : 2339,
    "maxX" : 2534,
    "minY" : 1055,
    "maxY" : 1291,
    "prop" : {
      "x" : 2464,
      "y" : 1201,
      "width" : 64,
      "height" : 28
    },
    "textPosition" : {
      "x" : 2469,
      "y" : 1204
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2528,
          "y" : 1201
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2528,
          "y" : 1201
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74766,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2501,
          "y" : 1232
        },
        "to" : {
          "x" : 2525,
          "y" : 1291
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74907,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2486,
          "y" : 1198
        },
        "to" : {
          "x" : 2390,
          "y" : 1055
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74915,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2461,
          "y" : 1224
        },
        "to" : {
          "x" : 2339,
          "y" : 1260
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74811,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2498,
          "y" : 1198
        },
        "to" : {
          "x" : 2505,
          "y" : 1166
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74854,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2468,
          "y" : 1198
        },
        "to" : {
          "x" : 2374,
          "y" : 1153
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74742,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74747,
    "reactomeId" : 10033715,
    "displayName" : "ub-DVL:CUL3:KLHL12:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 830,
      "y" : 1273
    },
    "minX" : 784,
    "maxX" : 882,
    "minY" : 1249,
    "maxY" : 1291,
    "prop" : {
      "x" : 784,
      "y" : 1255,
      "width" : 92,
      "height" : 36
    },
    "textPosition" : {
      "x" : 785,
      "y" : 1256
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 876,
          "y" : 1255
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 876,
          "y" : 1255
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74745,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74748,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 74746,
    "reactomeId" : 9985374,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 899,
      "y" : 1186
    },
    "minX" : 830,
    "maxX" : 960,
    "minY" : 1175,
    "maxY" : 1281,
    "prop" : {
      "x" : 861,
      "y" : 1175,
      "width" : 76,
      "height" : 22
    },
    "textPosition" : {
      "x" : 886,
      "y" : 1175
    },
    "connectors" : [ {
      "edgeId" : 74745,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 855,
          "y" : 1184
        },
        "to" : {
          "x" : 830,
          "y" : 1184
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74748,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 906,
          "y" : 1203
        },
        "to" : {
          "x" : 960,
          "y" : 1281
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 913,
          "y" : 1206
        },
        "b" : {
          "x" : 906,
          "y" : 1203
        },
        "c" : {
          "x" : 907,
          "y" : 1211
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 907,
          "y" : 1211
        }
      }
    } ]
  }, {
    "id" : 74749,
    "reactomeId" : 9985422,
    "displayName" : "26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 937,
      "y" : 1353
    },
    "minX" : 670,
    "maxX" : 1339,
    "minY" : 1292,
    "maxY" : 1665,
    "prop" : {
      "x" : 883,
      "y" : 1335,
      "width" : 108,
      "height" : 36
    },
    "textPosition" : {
      "x" : 895,
      "y" : 1336
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 991,
          "y" : 1335
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 991,
          "y" : 1335
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74798,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 960,
          "y" : 1374
        },
        "to" : {
          "x" : 1332,
          "y" : 1658
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1335,
          "y" : 1661
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1335,
          "y" : 1661
        }
      }
    }, {
      "edgeId" : 74867,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 880,
          "y" : 1352
        },
        "to" : {
          "x" : 678,
          "y" : 1352
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 674,
          "y" : 1352
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 674,
          "y" : 1352
        }
      }
    }, {
      "edgeId" : 74748,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 934,
          "y" : 1332
        },
        "to" : {
          "x" : 929,
          "y" : 1300
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 929,
          "y" : 1296
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 929,
          "y" : 1296
        }
      }
    }, {
      "edgeId" : 74878,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 941,
          "y" : 1374
        },
        "to" : {
          "x" : 968,
          "y" : 1467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 969,
          "y" : 1470
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 969,
          "y" : 1470
        }
      }
    } ]
  }, {
    "id" : 74751,
    "reactomeId" : 10004007,
    "displayName" : "CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1687,
      "y" : 1061
    },
    "minX" : 1613,
    "maxX" : 1767,
    "minY" : 1023,
    "maxY" : 1093,
    "prop" : {
      "x" : 1613,
      "y" : 1029,
      "width" : 148,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1616,
      "y" : 1044
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1761,
          "y" : 1029
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1761,
          "y" : 1029
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74750,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 74883,
    "reactomeId" : 10051262,
    "displayName" : "ZNRF3 ubiquitinates FZD to promote its downregulation",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 290,
      "y" : 1430
    },
    "minX" : 284,
    "maxX" : 296,
    "minY" : 1407,
    "maxY" : 1468,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 292,
        "y" : 1407
      },
      "to" : {
        "x" : 290,
        "y" : 1430
      }
    }, {
      "from" : {
        "x" : 290,
        "y" : 1430
      },
      "to" : {
        "x" : 292,
        "y" : 1468
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 288,
        "y" : 1461
      },
      "b" : {
        "x" : 292,
        "y" : 1468
      },
      "c" : {
        "x" : 296,
        "y" : 1461
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 296,
        "y" : 1461
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 284,
        "y" : 1424
      },
      "b" : {
        "x" : 296,
        "y" : 1436
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 290,
        "y" : 1430
      }
    },
    "inputs" : [ {
      "id" : 74882,
      "points" : [ {
        "x" : 293,
        "y" : 1390
      } ]
    }, {
      "id" : 74884,
      "points" : [ {
        "x" : 371,
        "y" : 1396
      } ]
    } ],
    "outputs" : [ {
      "id" : 74885
    } ],
    "catalysts" : [ {
      "id" : 74882,
      "points" : [ {
        "x" : 269,
        "y" : 1390
      }, {
        "x" : 246,
        "y" : 1417
      } ]
    } ]
  }, {
    "id" : 74757,
    "reactomeId" : 10004005,
    "displayName" : "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1817,
      "y" : 419
    },
    "minX" : 1768,
    "maxX" : 1845,
    "minY" : 413,
    "maxY" : 425,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1768,
        "y" : 420
      },
      "to" : {
        "x" : 1817,
        "y" : 419
      }
    }, {
      "from" : {
        "x" : 1817,
        "y" : 419
      },
      "to" : {
        "x" : 1845,
        "y" : 418
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1811,
        "y" : 413
      },
      "b" : {
        "x" : 1823,
        "y" : 425
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1817,
        "y" : 419
      }
    },
    "inputs" : [ {
      "id" : 74758,
      "points" : [ {
        "x" : 1733,
        "y" : 460
      } ],
      "stoichiometry" : 5
    }, {
      "id" : 74737,
      "points" : [ {
        "x" : 1697,
        "y" : 416
      } ]
    } ],
    "outputs" : [ {
      "id" : 74759,
      "points" : [ {
        "x" : 1864,
        "y" : 463
      } ],
      "stoichiometry" : 5
    }, {
      "id" : 74760,
      "points" : [ {
        "x" : 1886,
        "y" : 418
      } ]
    } ],
    "catalysts" : [ {
      "id" : 74737,
      "points" : [ {
        "x" : 1697,
        "y" : 391
      }, {
        "x" : 1744,
        "y" : 373
      } ]
    } ]
  }, {
    "id" : 74886,
    "reactomeId" : 10051240,
    "displayName" : "USP8 deubiquitinates FZD to potentiate WNT signaling",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 293,
      "y" : 1143
    },
    "minX" : 287,
    "maxX" : 299,
    "minY" : 1124,
    "maxY" : 1169,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 291,
        "y" : 1124
      },
      "to" : {
        "x" : 293,
        "y" : 1143
      }
    }, {
      "from" : {
        "x" : 293,
        "y" : 1143
      },
      "to" : {
        "x" : 295,
        "y" : 1169
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 287,
        "y" : 1137
      },
      "b" : {
        "x" : 299,
        "y" : 1149
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 293,
        "y" : 1143
      }
    },
    "inputs" : [ {
      "id" : 74887,
      "points" : [ {
        "x" : 355,
        "y" : 1109
      } ]
    }, {
      "id" : 74888,
      "points" : [ {
        "x" : 289,
        "y" : 1102
      } ]
    } ],
    "outputs" : [ {
      "id" : 74880,
      "points" : [ {
        "x" : 296,
        "y" : 1200
      } ]
    }, {
      "id" : 74884,
      "points" : [ {
        "x" : 415,
        "y" : 1371
      }, {
        "x" : 393,
        "y" : 1204
      } ]
    } ],
    "catalysts" : [ {
      "id" : 74889,
      "points" : [ {
        "x" : 331,
        "y" : 1145
      } ]
    } ]
  }, {
    "id" : 74761,
    "reactomeId" : 10004061,
    "displayName" : "Beta-catenin:TCF associates with BCL9 and PYGO",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2885,
      "y" : 1300
    },
    "minX" : 2847,
    "maxX" : 2923,
    "minY" : 1294,
    "maxY" : 1306,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2847,
        "y" : 1300
      },
      "to" : {
        "x" : 2885,
        "y" : 1300
      }
    }, {
      "from" : {
        "x" : 2885,
        "y" : 1300
      },
      "to" : {
        "x" : 2923,
        "y" : 1301
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2916,
        "y" : 1305
      },
      "b" : {
        "x" : 2923,
        "y" : 1301
      },
      "c" : {
        "x" : 2916,
        "y" : 1297
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2916,
        "y" : 1297
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2885,
        "y" : 1300
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2885,
        "y" : 1300
      }
    },
    "inputs" : [ {
      "id" : 74762,
      "points" : [ {
        "x" : 2762,
        "y" : 1294
      } ]
    }, {
      "id" : 74763,
      "points" : [ {
        "x" : 2890,
        "y" : 1328
      } ]
    }, {
      "id" : 74764,
      "points" : [ {
        "x" : 2818,
        "y" : 1337
      } ]
    } ],
    "outputs" : [ {
      "id" : 74765
    } ]
  }, {
    "id" : 74890,
    "reactomeId" : 10051210,
    "displayName" : "RSPOs bind LGRs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 201,
      "y" : 811
    },
    "minX" : 195,
    "maxX" : 207,
    "minY" : 791,
    "maxY" : 844,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 200,
        "y" : 791
      },
      "to" : {
        "x" : 201,
        "y" : 811
      }
    }, {
      "from" : {
        "x" : 201,
        "y" : 811
      },
      "to" : {
        "x" : 195,
        "y" : 844
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 192,
        "y" : 836
      },
      "b" : {
        "x" : 195,
        "y" : 844
      },
      "c" : {
        "x" : 200,
        "y" : 838
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 200,
        "y" : 838
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 201,
        "y" : 811
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 201,
        "y" : 811
      }
    },
    "inputs" : [ {
      "id" : 74891,
      "points" : [ {
        "x" : 218,
        "y" : 774
      } ]
    }, {
      "id" : 74892,
      "points" : [ {
        "x" : 147,
        "y" : 763
      } ]
    } ],
    "outputs" : [ {
      "id" : 74893
    } ]
  }, {
    "id" : 74894,
    "reactomeId" : 10051208,
    "displayName" : "RSPO:LGR binds ZNRF3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 269,
      "y" : 864
    },
    "minX" : 258,
    "maxX" : 289,
    "minY" : 858,
    "maxY" : 870,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 258,
        "y" : 861
      },
      "to" : {
        "x" : 269,
        "y" : 864
      }
    }, {
      "from" : {
        "x" : 269,
        "y" : 864
      },
      "to" : {
        "x" : 289,
        "y" : 864
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 282,
        "y" : 868
      },
      "b" : {
        "x" : 289,
        "y" : 864
      },
      "c" : {
        "x" : 282,
        "y" : 860
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 282,
        "y" : 860
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 269,
        "y" : 864
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 269,
        "y" : 864
      }
    },
    "inputs" : [ {
      "id" : 74893,
      "points" : [ {
        "x" : 237,
        "y" : 861
      } ]
    }, {
      "id" : 74881,
      "points" : [ {
        "x" : 143,
        "y" : 1049
      } ]
    } ],
    "outputs" : [ {
      "id" : 74895
    } ]
  }, {
    "id" : 74766,
    "reactomeId" : 10048371,
    "displayName" : "Beta-catenin displaces TLE:HDAC1 from TCF/LEF",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2555,
      "y" : 1291
    },
    "minX" : 2525,
    "maxX" : 2595,
    "minY" : 1285,
    "maxY" : 1297,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 2525,
        "y" : 1291
      },
      "to" : {
        "x" : 2555,
        "y" : 1291
      }
    }, {
      "from" : {
        "x" : 2555,
        "y" : 1291
      },
      "to" : {
        "x" : 2595,
        "y" : 1291
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 2555,
        "y" : 1291
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 2555,
        "y" : 1291
      }
    },
    "inputs" : [ {
      "id" : 74744,
      "points" : [ {
        "x" : 2501,
        "y" : 1232
      } ]
    }, {
      "id" : 74767,
      "points" : [ {
        "x" : 2500,
        "y" : 1291
      } ]
    } ],
    "outputs" : [ {
      "id" : 74762,
      "points" : [ {
        "x" : 2635,
        "y" : 1291
      } ]
    }, {
      "id" : 74768,
      "points" : [ {
        "x" : 2613,
        "y" : 1314
      } ]
    }, {
      "id" : 74769,
      "points" : [ {
        "x" : 2546,
        "y" : 1333
      } ]
    } ]
  }, {
    "id" : 74896,
    "reactomeId" : 10051253,
    "displayName" : "ZNRF3 autoubiquitinates to promote its internalization",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 326,
      "y" : 943
    },
    "minX" : 320,
    "maxX" : 332,
    "minY" : 922,
    "maxY" : 975,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 328,
        "y" : 922
      },
      "to" : {
        "x" : 326,
        "y" : 943
      }
    }, {
      "from" : {
        "x" : 326,
        "y" : 943
      },
      "to" : {
        "x" : 326,
        "y" : 975
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 322,
        "y" : 968
      },
      "b" : {
        "x" : 326,
        "y" : 975
      },
      "c" : {
        "x" : 330,
        "y" : 968
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 330,
        "y" : 968
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 320,
        "y" : 937
      },
      "b" : {
        "x" : 332,
        "y" : 949
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 326,
        "y" : 943
      }
    },
    "inputs" : [ {
      "id" : 74895,
      "points" : [ {
        "x" : 334,
        "y" : 893
      } ]
    }, {
      "id" : 74897,
      "points" : [ {
        "x" : 387,
        "y" : 913
      } ]
    } ],
    "outputs" : [ {
      "id" : 74898
    } ],
    "catalysts" : [ {
      "id" : 74895,
      "points" : [ {
        "x" : 306,
        "y" : 893
      }, {
        "x" : 268,
        "y" : 918
      } ]
    } ]
  }, {
    "id" : 74899,
    "reactomeId" : 10053781,
    "displayName" : "Canonical WNT signaling through the atypical receptor RYK",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 247,
      "y" : 602
    },
    "minX" : 241,
    "maxX" : 253,
    "minY" : 583,
    "maxY" : 648,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 247,
        "y" : 583
      },
      "to" : {
        "x" : 247,
        "y" : 602
      }
    }, {
      "from" : {
        "x" : 247,
        "y" : 602
      },
      "to" : {
        "x" : 250,
        "y" : 648
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 246,
        "y" : 641
      },
      "b" : {
        "x" : 250,
        "y" : 648
      },
      "c" : {
        "x" : 254,
        "y" : 641
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 254,
        "y" : 641
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 247,
        "y" : 602
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 247,
        "y" : 602
      }
    },
    "inputs" : [ {
      "id" : 74900,
      "points" : [ {
        "x" : 250,
        "y" : 529
      } ]
    }, {
      "id" : 74901,
      "points" : [ {
        "x" : 119,
        "y" : 543
      } ]
    } ],
    "outputs" : [ {
      "id" : 74902
    } ]
  }, {
    "id" : 74770,
    "reactomeId" : 10048687,
    "displayName" : "Beta-catenin recruits CBP/p300",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2890,
      "y" : 1154
    },
    "minX" : 2854,
    "maxX" : 2938,
    "minY" : 1148,
    "maxY" : 1162,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2854,
        "y" : 1162
      },
      "to" : {
        "x" : 2890,
        "y" : 1154
      }
    }, {
      "from" : {
        "x" : 2890,
        "y" : 1154
      },
      "to" : {
        "x" : 2938,
        "y" : 1148
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2932,
        "y" : 1153
      },
      "b" : {
        "x" : 2938,
        "y" : 1148
      },
      "c" : {
        "x" : 2931,
        "y" : 1145
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2931,
        "y" : 1145
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2890,
        "y" : 1154
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2890,
        "y" : 1154
      }
    },
    "inputs" : [ {
      "id" : 74762,
      "points" : [ {
        "x" : 2711,
        "y" : 1277
      } ]
    }, {
      "id" : 74771,
      "points" : [ {
        "x" : 2824,
        "y" : 1161
      } ]
    } ],
    "outputs" : [ {
      "id" : 74772
    } ]
  }, {
    "id" : 74773,
    "reactomeId" : 10048683,
    "displayName" : "Beta-catenin recruits CDC73 and LEO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2888,
      "y" : 1211
    },
    "minX" : 2829,
    "maxX" : 2949,
    "minY" : 1205,
    "maxY" : 1220,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2829,
        "y" : 1220
      },
      "to" : {
        "x" : 2888,
        "y" : 1211
      }
    }, {
      "from" : {
        "x" : 2888,
        "y" : 1211
      },
      "to" : {
        "x" : 2949,
        "y" : 1212
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2942,
        "y" : 1216
      },
      "b" : {
        "x" : 2949,
        "y" : 1212
      },
      "c" : {
        "x" : 2942,
        "y" : 1208
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2942,
        "y" : 1208
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2888,
        "y" : 1211
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2888,
        "y" : 1211
      }
    },
    "inputs" : [ {
      "id" : 74762,
      "points" : [ {
        "x" : 2719,
        "y" : 1277
      } ]
    }, {
      "id" : 74774,
      "points" : [ {
        "x" : 2802,
        "y" : 1260
      } ]
    }, {
      "id" : 74775,
      "points" : [ {
        "x" : 2848,
        "y" : 1248
      } ]
    } ],
    "outputs" : [ {
      "id" : 74776
    } ]
  }, {
    "id" : 74903,
    "reactomeId" : 10053771,
    "displayName" : "FRAT proteins bind GSK3beta",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1903,
      "y" : 790
    },
    "minX" : 1897,
    "maxX" : 1909,
    "minY" : 760,
    "maxY" : 821,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1903,
        "y" : 760
      },
      "to" : {
        "x" : 1903,
        "y" : 790
      }
    }, {
      "from" : {
        "x" : 1903,
        "y" : 790
      },
      "to" : {
        "x" : 1904,
        "y" : 821
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1900,
        "y" : 814
      },
      "b" : {
        "x" : 1904,
        "y" : 821
      },
      "c" : {
        "x" : 1908,
        "y" : 814
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1908,
        "y" : 814
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1903,
        "y" : 790
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1903,
        "y" : 790
      }
    },
    "inputs" : [ {
      "id" : 74904,
      "points" : [ {
        "x" : 1855,
        "y" : 704
      } ]
    }, {
      "id" : 74905,
      "points" : [ {
        "x" : 1945,
        "y" : 697
      } ]
    } ],
    "outputs" : [ {
      "id" : 74906
    } ]
  }, {
    "id" : 74777,
    "reactomeId" : 10048679,
    "displayName" : "Beta-catenin recruits SMARCA4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2679,
      "y" : 1099
    },
    "minX" : 2673,
    "maxX" : 2685,
    "minY" : 1049,
    "maxY" : 1170,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2681,
        "y" : 1170
      },
      "to" : {
        "x" : 2679,
        "y" : 1099
      }
    }, {
      "from" : {
        "x" : 2679,
        "y" : 1099
      },
      "to" : {
        "x" : 2678,
        "y" : 1049
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2682,
        "y" : 1056
      },
      "b" : {
        "x" : 2678,
        "y" : 1049
      },
      "c" : {
        "x" : 2674,
        "y" : 1056
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2674,
        "y" : 1056
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2679,
        "y" : 1099
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2679,
        "y" : 1099
      }
    },
    "inputs" : [ {
      "id" : 74762,
      "points" : [ {
        "x" : 2696,
        "y" : 1277
      } ]
    }, {
      "id" : 74778,
      "points" : [ {
        "x" : 2635,
        "y" : 1195
      } ]
    }, {
      "id" : 74779,
      "points" : [ {
        "x" : 2654,
        "y" : 1229
      } ]
    } ],
    "outputs" : [ {
      "id" : 74780
    } ]
  }, {
    "id" : 74907,
    "reactomeId" : 10054533,
    "displayName" : "CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2317,
      "y" : 925
    },
    "minX" : 2293,
    "maxX" : 2390,
    "minY" : 888,
    "maxY" : 1055,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2390,
        "y" : 1055
      },
      "to" : {
        "x" : 2317,
        "y" : 925
      }
    }, {
      "from" : {
        "x" : 2317,
        "y" : 925
      },
      "to" : {
        "x" : 2293,
        "y" : 888
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2300,
        "y" : 892
      },
      "b" : {
        "x" : 2293,
        "y" : 888
      },
      "c" : {
        "x" : 2293,
        "y" : 896
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2293,
        "y" : 896
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2317,
        "y" : 925
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2317,
        "y" : 925
      }
    },
    "inputs" : [ {
      "id" : 74908,
      "points" : [ {
        "x" : 2333,
        "y" : 1028
      } ]
    }, {
      "id" : 74744,
      "points" : [ {
        "x" : 2486,
        "y" : 1198
      } ]
    } ],
    "outputs" : [ {
      "id" : 74909
    } ]
  }, {
    "id" : 74781,
    "reactomeId" : 10048862,
    "displayName" : "Recruitment of MLL2 methyltransferase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3128,
      "y" : 1296
    },
    "minX" : 3087,
    "maxX" : 3176,
    "minY" : 1290,
    "maxY" : 1307,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3087,
        "y" : 1307
      },
      "to" : {
        "x" : 3128,
        "y" : 1296
      }
    }, {
      "from" : {
        "x" : 3128,
        "y" : 1296
      },
      "to" : {
        "x" : 3176,
        "y" : 1293
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3169,
        "y" : 1297
      },
      "b" : {
        "x" : 3176,
        "y" : 1293
      },
      "c" : {
        "x" : 3169,
        "y" : 1289
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3169,
        "y" : 1289
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3128,
        "y" : 1296
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3128,
        "y" : 1296
      }
    },
    "inputs" : [ {
      "id" : 74782,
      "points" : [ {
        "x" : 3078,
        "y" : 1338
      } ]
    }, {
      "id" : 74765,
      "points" : [ {
        "x" : 3047,
        "y" : 1305
      } ]
    } ],
    "outputs" : [ {
      "id" : 74783
    } ]
  }, {
    "id" : 74910,
    "reactomeId" : 10054571,
    "displayName" : "WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2524,
      "y" : 476
    },
    "minX" : 2518,
    "maxX" : 2530,
    "minY" : 440,
    "maxY" : 509,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 2522,
        "y" : 440
      },
      "to" : {
        "x" : 2524,
        "y" : 476
      }
    }, {
      "from" : {
        "x" : 2524,
        "y" : 476
      },
      "to" : {
        "x" : 2528,
        "y" : 509
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2523,
        "y" : 503
      },
      "b" : {
        "x" : 2528,
        "y" : 509
      },
      "c" : {
        "x" : 2531,
        "y" : 502
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2531,
        "y" : 502
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2518,
        "y" : 470
      },
      "b" : {
        "x" : 2530,
        "y" : 482
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2524,
        "y" : 476
      }
    },
    "inputs" : [ {
      "id" : 74911
    } ],
    "outputs" : [ {
      "id" : 74912
    } ]
  }, {
    "id" : 74913,
    "reactomeId" : 10054557,
    "displayName" : "DKK promotes clathrin-dependent internalization of LRP6",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 568,
      "y" : 523
    },
    "minX" : 512,
    "maxX" : 593,
    "minY" : 497,
    "maxY" : 569,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 593,
        "y" : 497
      },
      "to" : {
        "x" : 568,
        "y" : 523
      }
    }, {
      "from" : {
        "x" : 568,
        "y" : 523
      },
      "to" : {
        "x" : 512,
        "y" : 569
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 515,
        "y" : 562
      },
      "b" : {
        "x" : 512,
        "y" : 569
      },
      "c" : {
        "x" : 520,
        "y" : 568
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 520,
        "y" : 568
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 562,
        "y" : 517
      },
      "b" : {
        "x" : 574,
        "y" : 529
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 568,
        "y" : 523
      }
    },
    "inputs" : [ {
      "id" : 74831
    } ],
    "outputs" : [ {
      "id" : 74914
    } ]
  }, {
    "id" : 74784,
    "reactomeId" : 10049129,
    "displayName" : "Tankyrase binds AXIN",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 756,
      "y" : 1799
    },
    "minX" : 733,
    "maxX" : 778,
    "minY" : 1793,
    "maxY" : 1805,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 733,
        "y" : 1797
      },
      "to" : {
        "x" : 756,
        "y" : 1799
      }
    }, {
      "from" : {
        "x" : 756,
        "y" : 1799
      },
      "to" : {
        "x" : 778,
        "y" : 1798
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 771,
        "y" : 1802
      },
      "b" : {
        "x" : 778,
        "y" : 1798
      },
      "c" : {
        "x" : 771,
        "y" : 1794
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 771,
        "y" : 1794
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 756,
        "y" : 1799
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 756,
        "y" : 1799
      }
    },
    "inputs" : [ {
      "id" : 74785,
      "points" : [ {
        "x" : 730,
        "y" : 1769
      } ]
    }, {
      "id" : 74786,
      "points" : [ {
        "x" : 627,
        "y" : 1797
      } ]
    } ],
    "outputs" : [ {
      "id" : 74787
    } ]
  }, {
    "id" : 74915,
    "reactomeId" : 10057043,
    "displayName" : "Beta-catenin binds SOX proteins",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2339,
      "y" : 1293
    },
    "minX" : 2333,
    "maxX" : 2345,
    "minY" : 1260,
    "maxY" : 1326,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2339,
        "y" : 1260
      },
      "to" : {
        "x" : 2339,
        "y" : 1293
      }
    }, {
      "from" : {
        "x" : 2339,
        "y" : 1293
      },
      "to" : {
        "x" : 2339,
        "y" : 1326
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2335,
        "y" : 1319
      },
      "b" : {
        "x" : 2339,
        "y" : 1326
      },
      "c" : {
        "x" : 2343,
        "y" : 1319
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2343,
        "y" : 1319
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2339,
        "y" : 1293
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2339,
        "y" : 1293
      }
    },
    "inputs" : [ {
      "id" : 74916,
      "points" : [ {
        "x" : 2315,
        "y" : 1254
      } ]
    }, {
      "id" : 74744,
      "points" : [ {
        "x" : 2461,
        "y" : 1224
      } ]
    } ],
    "outputs" : [ {
      "id" : 74917
    } ]
  }, {
    "id" : 74788,
    "reactomeId" : 10049114,
    "displayName" : "Tankyrase ADP-ribosylates AXIN",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 901,
      "y" : 1796
    },
    "minX" : 878,
    "maxX" : 920,
    "minY" : 1790,
    "maxY" : 1802,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 878,
        "y" : 1796
      },
      "to" : {
        "x" : 901,
        "y" : 1796
      }
    }, {
      "from" : {
        "x" : 901,
        "y" : 1796
      },
      "to" : {
        "x" : 920,
        "y" : 1796
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 895,
        "y" : 1790
      },
      "b" : {
        "x" : 907,
        "y" : 1802
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 901,
        "y" : 1796
      }
    },
    "inputs" : [ {
      "id" : 74787,
      "points" : [ {
        "x" : 856,
        "y" : 1796
      } ]
    }, {
      "id" : 74789,
      "points" : [ {
        "x" : 853,
        "y" : 1818
      } ]
    } ],
    "outputs" : [ {
      "id" : 74790,
      "points" : [ {
        "x" : 942,
        "y" : 1796
      } ]
    }, {
      "id" : 74791,
      "points" : [ {
        "x" : 935,
        "y" : 1827
      } ]
    } ],
    "catalysts" : [ {
      "id" : 74787,
      "points" : [ {
        "x" : 834,
        "y" : 1783
      }, {
        "x" : 869,
        "y" : 1765
      } ]
    } ]
  }, {
    "id" : 74918,
    "reactomeId" : 10058720,
    "displayName" : "TCF:Beta-catenin binds SOX proteins",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2372,
      "y" : 1492
    },
    "minX" : 2365,
    "maxX" : 2379,
    "minY" : 1453,
    "maxY" : 1530,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2379,
        "y" : 1453
      },
      "to" : {
        "x" : 2372,
        "y" : 1492
      }
    }, {
      "from" : {
        "x" : 2372,
        "y" : 1492
      },
      "to" : {
        "x" : 2365,
        "y" : 1530
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2362,
        "y" : 1522
      },
      "b" : {
        "x" : 2365,
        "y" : 1530
      },
      "c" : {
        "x" : 2370,
        "y" : 1524
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2370,
        "y" : 1524
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2372,
        "y" : 1492
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2372,
        "y" : 1492
      }
    },
    "inputs" : [ {
      "id" : 74762,
      "points" : [ {
        "x" : 2689,
        "y" : 1306
      }, {
        "x" : 2646,
        "y" : 1360
      } ]
    }, {
      "id" : 74919,
      "points" : [ {
        "x" : 2320,
        "y" : 1435
      } ]
    } ],
    "outputs" : [ {
      "id" : 74920
    } ]
  }, {
    "id" : 74792,
    "reactomeId" : 10049127,
    "displayName" : "RNF146 ubiquitinates ADP-ribosylated AXIN",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1284,
      "y" : 1795
    },
    "minX" : 1248,
    "maxX" : 1417,
    "minY" : 1789,
    "maxY" : 1801,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1248,
        "y" : 1792
      },
      "to" : {
        "x" : 1284,
        "y" : 1795
      }
    }, {
      "from" : {
        "x" : 1284,
        "y" : 1795
      },
      "to" : {
        "x" : 1417,
        "y" : 1789
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1410,
        "y" : 1793
      },
      "b" : {
        "x" : 1417,
        "y" : 1789
      },
      "c" : {
        "x" : 1410,
        "y" : 1785
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1410,
        "y" : 1785
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1278,
        "y" : 1789
      },
      "b" : {
        "x" : 1290,
        "y" : 1801
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1284,
        "y" : 1795
      }
    },
    "inputs" : [ {
      "id" : 74793,
      "points" : [ {
        "x" : 1226,
        "y" : 1792
      } ]
    }, {
      "id" : 74794,
      "points" : [ {
        "x" : 1243,
        "y" : 1714
      } ]
    } ],
    "outputs" : [ {
      "id" : 74795
    } ],
    "catalysts" : [ {
      "id" : 74793,
      "points" : [ {
        "x" : 1226,
        "y" : 1810
      }, {
        "x" : 1263,
        "y" : 1823
      } ]
    } ]
  }, {
    "id" : 74796,
    "reactomeId" : 10049105,
    "displayName" : "RNF146 binds RibC-AXIN:TNKS complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1088,
      "y" : 1794
    },
    "minX" : 1069,
    "maxX" : 1111,
    "minY" : 1788,
    "maxY" : 1800,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1069,
        "y" : 1794
      },
      "to" : {
        "x" : 1088,
        "y" : 1794
      }
    }, {
      "from" : {
        "x" : 1088,
        "y" : 1794
      },
      "to" : {
        "x" : 1111,
        "y" : 1794
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1104,
        "y" : 1798
      },
      "b" : {
        "x" : 1111,
        "y" : 1794
      },
      "c" : {
        "x" : 1104,
        "y" : 1790
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1104,
        "y" : 1790
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1088,
        "y" : 1794
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1088,
        "y" : 1794
      }
    },
    "inputs" : [ {
      "id" : 74790,
      "points" : [ {
        "x" : 1054,
        "y" : 1794
      } ]
    }, {
      "id" : 74797,
      "points" : [ {
        "x" : 1040,
        "y" : 1768
      } ]
    } ],
    "outputs" : [ {
      "id" : 74793
    } ]
  }, {
    "id" : 74799,
    "reactomeId" : 10048720,
    "displayName" : "XIAP binds TLE",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2595,
      "y" : 1404
    },
    "minX" : 2573,
    "maxX" : 2623,
    "minY" : 1398,
    "maxY" : 1410,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2573,
        "y" : 1403
      },
      "to" : {
        "x" : 2595,
        "y" : 1404
      }
    }, {
      "from" : {
        "x" : 2595,
        "y" : 1404
      },
      "to" : {
        "x" : 2623,
        "y" : 1404
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2616,
        "y" : 1408
      },
      "b" : {
        "x" : 2623,
        "y" : 1404
      },
      "c" : {
        "x" : 2616,
        "y" : 1400
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2616,
        "y" : 1400
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2595,
        "y" : 1404
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2595,
        "y" : 1404
      }
    },
    "inputs" : [ {
      "id" : 74800,
      "points" : [ {
        "x" : 2547,
        "y" : 1422
      } ]
    }, {
      "id" : 74769,
      "points" : [ {
        "x" : 2542,
        "y" : 1367
      } ]
    } ],
    "outputs" : [ {
      "id" : 74801
    } ]
  }, {
    "id" : 74798,
    "reactomeId" : 10049138,
    "displayName" : "Ub-RibC-AXIN is degraded by the proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1345,
      "y" : 1668
    },
    "minX" : 1130,
    "maxX" : 1463,
    "minY" : 1662,
    "maxY" : 1766,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1463,
        "y" : 1766
      },
      "to" : {
        "x" : 1345,
        "y" : 1668
      }
    }, {
      "from" : {
        "x" : 1345,
        "y" : 1668
      },
      "to" : {
        "x" : 1130,
        "y" : 1663
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1339,
        "y" : 1662
      },
      "b" : {
        "x" : 1351,
        "y" : 1674
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1345,
        "y" : 1668
      }
    },
    "inputs" : [ {
      "id" : 74795
    } ],
    "outputs" : [ {
      "id" : 74797,
      "points" : [ {
        "x" : 1041,
        "y" : 1740
      } ]
    }, {
      "id" : 74785,
      "points" : [ {
        "x" : 767,
        "y" : 1745
      } ]
    }, {
      "id" : 74794,
      "points" : [ {
        "x" : 1206,
        "y" : 1680
      } ]
    } ],
    "catalysts" : [ {
      "id" : 74749,
      "points" : [ {
        "x" : 960,
        "y" : 1374
      } ]
    } ]
  }, {
    "id" : 74802,
    "reactomeId" : 10048718,
    "displayName" : "XIAP monoubiquinates TLE",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2759,
      "y" : 1411
    },
    "minX" : 2742,
    "maxX" : 2786,
    "minY" : 1405,
    "maxY" : 1417,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2742,
        "y" : 1413
      },
      "to" : {
        "x" : 2759,
        "y" : 1411
      }
    }, {
      "from" : {
        "x" : 2759,
        "y" : 1411
      },
      "to" : {
        "x" : 2786,
        "y" : 1412
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2779,
        "y" : 1416
      },
      "b" : {
        "x" : 2786,
        "y" : 1412
      },
      "c" : {
        "x" : 2779,
        "y" : 1408
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2779,
        "y" : 1408
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2753,
        "y" : 1405
      },
      "b" : {
        "x" : 2765,
        "y" : 1417
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2759,
        "y" : 1411
      }
    },
    "inputs" : [ {
      "id" : 74803,
      "points" : [ {
        "x" : 2712,
        "y" : 1462
      } ]
    }, {
      "id" : 74801,
      "points" : [ {
        "x" : 2715,
        "y" : 1410
      } ]
    } ],
    "outputs" : [ {
      "id" : 74804
    } ],
    "catalysts" : [ {
      "id" : 74801,
      "points" : [ {
        "x" : 2686,
        "y" : 1392
      }, {
        "x" : 2714,
        "y" : 1377
      } ]
    } ]
  }, {
    "id" : 74805,
    "reactomeId" : 10048839,
    "displayName" : "beta-catenin is replaced by repression complexes at the promoter",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3624,
      "y" : 1296
    },
    "minX" : 3589,
    "maxX" : 3650,
    "minY" : 1290,
    "maxY" : 1302,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 3589,
        "y" : 1296
      },
      "to" : {
        "x" : 3624,
        "y" : 1296
      }
    }, {
      "from" : {
        "x" : 3624,
        "y" : 1296
      },
      "to" : {
        "x" : 3650,
        "y" : 1294
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3618,
        "y" : 1290
      },
      "b" : {
        "x" : 3630,
        "y" : 1302
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3624,
        "y" : 1296
      }
    },
    "inputs" : [ {
      "id" : 74806,
      "points" : [ {
        "x" : 3556,
        "y" : 1251
      } ]
    }, {
      "id" : 74807,
      "points" : [ {
        "x" : 3567,
        "y" : 1296
      } ]
    } ],
    "outputs" : [ {
      "id" : 74808,
      "points" : [ {
        "x" : 3681,
        "y" : 1294
      } ]
    }, {
      "id" : 74767,
      "points" : [ {
        "x" : 2452,
        "y" : 1313
      }, {
        "x" : 2452,
        "y" : 1579
      }, {
        "x" : 3624,
        "y" : 1588
      } ]
    } ]
  }, {
    "id" : 74809,
    "reactomeId" : 10048722,
    "displayName" : "XIAP dissociates from ub-TLE",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2905,
      "y" : 1417
    },
    "minX" : 2882,
    "maxX" : 2916,
    "minY" : 1411,
    "maxY" : 1423,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 2882,
        "y" : 1416
      },
      "to" : {
        "x" : 2905,
        "y" : 1417
      }
    }, {
      "from" : {
        "x" : 2905,
        "y" : 1417
      },
      "to" : {
        "x" : 2916,
        "y" : 1418
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 2905,
        "y" : 1417
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 2905,
        "y" : 1417
      }
    },
    "inputs" : [ {
      "id" : 74804
    } ],
    "outputs" : [ {
      "id" : 74810,
      "points" : [ {
        "x" : 2935,
        "y" : 1419
      } ]
    }, {
      "id" : 74800,
      "points" : [ {
        "x" : 2544,
        "y" : 1450
      }, {
        "x" : 2629,
        "y" : 1543
      }, {
        "x" : 2866,
        "y" : 1541
      } ]
    } ]
  }, {
    "id" : 74811,
    "reactomeId" : 10049170,
    "displayName" : "CBY1 binds beta-catenin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2515,
      "y" : 1139
    },
    "minX" : 2505,
    "maxX" : 2524,
    "minY" : 1110,
    "maxY" : 1166,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2505,
        "y" : 1166
      },
      "to" : {
        "x" : 2515,
        "y" : 1139
      }
    }, {
      "from" : {
        "x" : 2515,
        "y" : 1139
      },
      "to" : {
        "x" : 2524,
        "y" : 1110
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2526,
        "y" : 1118
      },
      "b" : {
        "x" : 2524,
        "y" : 1110
      },
      "c" : {
        "x" : 2518,
        "y" : 1115
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2518,
        "y" : 1115
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2515,
        "y" : 1139
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2515,
        "y" : 1139
      }
    },
    "inputs" : [ {
      "id" : 74744,
      "points" : [ {
        "x" : 2498,
        "y" : 1198
      } ]
    }, {
      "id" : 74812,
      "points" : [ {
        "x" : 2532,
        "y" : 1177
      } ]
    } ],
    "outputs" : [ {
      "id" : 74813
    } ]
  }, {
    "id" : 74814,
    "reactomeId" : 10049194,
    "displayName" : "AKT phosphorylates CBY1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2536,
      "y" : 1024
    },
    "minX" : 2530,
    "maxX" : 2542,
    "minY" : 992,
    "maxY" : 1046,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2530,
        "y" : 1046
      },
      "to" : {
        "x" : 2536,
        "y" : 1024
      }
    }, {
      "from" : {
        "x" : 2536,
        "y" : 1024
      },
      "to" : {
        "x" : 2535,
        "y" : 992
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2530,
        "y" : 1018
      },
      "b" : {
        "x" : 2542,
        "y" : 1030
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2536,
        "y" : 1024
      }
    },
    "inputs" : [ {
      "id" : 74815,
      "points" : [ {
        "x" : 2564,
        "y" : 1055
      } ]
    }, {
      "id" : 74813,
      "points" : [ {
        "x" : 2528,
        "y" : 1081
      } ]
    } ],
    "outputs" : [ {
      "id" : 74816,
      "points" : [ {
        "x" : 2562,
        "y" : 985
      } ]
    }, {
      "id" : 74817,
      "points" : [ {
        "x" : 2531,
        "y" : 959
      } ]
    } ],
    "catalysts" : [ {
      "id" : 74818,
      "points" : [ {
        "x" : 2509,
        "y" : 1013
      } ]
    } ]
  }, {
    "id" : 74819,
    "reactomeId" : 10049189,
    "displayName" : "YWHAZ binds p-CBY:CTNNB1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2560,
      "y" : 876
    },
    "minX" : 2537,
    "maxX" : 2578,
    "minY" : 862,
    "maxY" : 889,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2537,
        "y" : 889
      },
      "to" : {
        "x" : 2560,
        "y" : 876
      }
    }, {
      "from" : {
        "x" : 2560,
        "y" : 876
      },
      "to" : {
        "x" : 2578,
        "y" : 862
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2575,
        "y" : 869
      },
      "b" : {
        "x" : 2578,
        "y" : 862
      },
      "c" : {
        "x" : 2570,
        "y" : 863
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2570,
        "y" : 863
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2560,
        "y" : 876
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2560,
        "y" : 876
      }
    },
    "inputs" : [ {
      "id" : 74817,
      "points" : [ {
        "x" : 2532,
        "y" : 921
      } ]
    }, {
      "id" : 74820,
      "points" : [ {
        "x" : 2519,
        "y" : 890
      } ]
    } ],
    "outputs" : [ {
      "id" : 74821
    } ]
  }, {
    "id" : 74822,
    "reactomeId" : 10049181,
    "displayName" : "XPO1 binds the beta-catenin:CBY complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2747,
      "y" : 832
    },
    "minX" : 2715,
    "maxX" : 2792,
    "minY" : 826,
    "maxY" : 838,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2715,
        "y" : 832
      },
      "to" : {
        "x" : 2747,
        "y" : 832
      }
    }, {
      "from" : {
        "x" : 2747,
        "y" : 832
      },
      "to" : {
        "x" : 2792,
        "y" : 830
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2785,
        "y" : 834
      },
      "b" : {
        "x" : 2792,
        "y" : 830
      },
      "c" : {
        "x" : 2785,
        "y" : 826
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2785,
        "y" : 826
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2747,
        "y" : 832
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2747,
        "y" : 832
      }
    },
    "inputs" : [ {
      "id" : 74821,
      "points" : [ {
        "x" : 2664,
        "y" : 836
      } ]
    }, {
      "id" : 74823,
      "points" : [ {
        "x" : 2717,
        "y" : 860
      } ]
    } ],
    "outputs" : [ {
      "id" : 74824
    } ]
  }, {
    "id" : 74825,
    "reactomeId" : 10049187,
    "displayName" : "YWHAZ and XPO1 mediate the nuclear export of beta-catenin",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2846,
      "y" : 720
    },
    "minX" : 2840,
    "maxX" : 2856,
    "minY" : 669,
    "maxY" : 808,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 2856,
        "y" : 808
      },
      "to" : {
        "x" : 2846,
        "y" : 720
      }
    }, {
      "from" : {
        "x" : 2846,
        "y" : 720
      },
      "to" : {
        "x" : 2846,
        "y" : 669
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2850,
        "y" : 676
      },
      "b" : {
        "x" : 2846,
        "y" : 669
      },
      "c" : {
        "x" : 2842,
        "y" : 676
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2842,
        "y" : 676
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2840,
        "y" : 714
      },
      "b" : {
        "x" : 2852,
        "y" : 726
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2846,
        "y" : 720
      }
    },
    "inputs" : [ {
      "id" : 74824
    } ],
    "outputs" : [ {
      "id" : 74826
    } ]
  }, {
    "id" : 74827,
    "reactomeId" : 10049230,
    "displayName" : "DKK and KRM bind LRP5/6",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 600,
      "y" : 402
    },
    "minX" : 581,
    "maxX" : 606,
    "minY" : 369,
    "maxY" : 455,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 581,
        "y" : 369
      },
      "to" : {
        "x" : 600,
        "y" : 402
      }
    }, {
      "from" : {
        "x" : 600,
        "y" : 402
      },
      "to" : {
        "x" : 606,
        "y" : 455
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 601,
        "y" : 449
      },
      "b" : {
        "x" : 606,
        "y" : 455
      },
      "c" : {
        "x" : 609,
        "y" : 448
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 609,
        "y" : 448
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 600,
        "y" : 402
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 600,
        "y" : 402
      }
    },
    "inputs" : [ {
      "id" : 74828,
      "points" : [ {
        "x" : 398,
        "y" : 385
      } ]
    }, {
      "id" : 74829,
      "points" : [ {
        "x" : 532,
        "y" : 359
      } ]
    }, {
      "id" : 74830,
      "points" : [ {
        "x" : 537,
        "y" : 390
      } ]
    } ],
    "outputs" : [ {
      "id" : 74831
    } ]
  }, {
    "id" : 74832,
    "reactomeId" : 10049202,
    "displayName" : "SOST binds LRP5/6",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 559,
      "y" : 290
    },
    "minX" : 514,
    "maxX" : 622,
    "minY" : 284,
    "maxY" : 338,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 514,
        "y" : 291
      },
      "to" : {
        "x" : 559,
        "y" : 290
      }
    }, {
      "from" : {
        "x" : 559,
        "y" : 290
      },
      "to" : {
        "x" : 622,
        "y" : 338
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 614,
        "y" : 337
      },
      "b" : {
        "x" : 622,
        "y" : 338
      },
      "c" : {
        "x" : 619,
        "y" : 331
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 619,
        "y" : 331
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 559,
        "y" : 290
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 559,
        "y" : 290
      }
    },
    "inputs" : [ {
      "id" : 74833,
      "points" : [ {
        "x" : 479,
        "y" : 285
      } ]
    }, {
      "id" : 74828,
      "points" : [ {
        "x" : 381,
        "y" : 369
      } ]
    } ],
    "outputs" : [ {
      "id" : 74834
    } ]
  }, {
    "id" : 74835,
    "reactomeId" : 10049245,
    "displayName" : "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 962,
      "y" : 715
    },
    "minX" : 934,
    "maxX" : 983,
    "minY" : 709,
    "maxY" : 721,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 934,
        "y" : 713
      },
      "to" : {
        "x" : 962,
        "y" : 715
      }
    }, {
      "from" : {
        "x" : 962,
        "y" : 715
      },
      "to" : {
        "x" : 983,
        "y" : 714
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 956,
        "y" : 709
      },
      "b" : {
        "x" : 968,
        "y" : 721
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 962,
        "y" : 715
      }
    },
    "inputs" : [ {
      "id" : 74836,
      "points" : [ {
        "x" : 914,
        "y" : 714
      } ]
    }, {
      "id" : 74837,
      "points" : [ {
        "x" : 930,
        "y" : 731
      } ]
    } ],
    "outputs" : [ {
      "id" : 74838,
      "points" : [ {
        "x" : 1001,
        "y" : 732
      } ]
    }, {
      "id" : 74839,
      "points" : [ {
        "x" : 1025,
        "y" : 714
      } ]
    } ],
    "catalysts" : [ {
      "id" : 74840,
      "points" : [ {
        "x" : 962,
        "y" : 777
      } ]
    } ]
  }, {
    "id" : 74841,
    "reactomeId" : 10049242,
    "displayName" : "Phosphorylated DVL recruits PIP5K1B to the plasma membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1177,
      "y" : 715
    },
    "minX" : 1155,
    "maxX" : 1201,
    "minY" : 709,
    "maxY" : 721,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1155,
        "y" : 714
      },
      "to" : {
        "x" : 1177,
        "y" : 715
      }
    }, {
      "from" : {
        "x" : 1177,
        "y" : 715
      },
      "to" : {
        "x" : 1201,
        "y" : 715
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1194,
        "y" : 719
      },
      "b" : {
        "x" : 1201,
        "y" : 715
      },
      "c" : {
        "x" : 1194,
        "y" : 711
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1194,
        "y" : 711
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1177,
        "y" : 715
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1177,
        "y" : 715
      }
    },
    "inputs" : [ {
      "id" : 74839,
      "points" : [ {
        "x" : 1133,
        "y" : 714
      } ]
    }, {
      "id" : 74842,
      "points" : [ {
        "x" : 1130,
        "y" : 769
      } ]
    } ],
    "outputs" : [ {
      "id" : 74843
    } ]
  }, {
    "id" : 74844,
    "reactomeId" : 10049248,
    "displayName" : "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1233,
      "y" : 457
    },
    "minX" : 1198,
    "maxX" : 1262,
    "minY" : 451,
    "maxY" : 463,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1198,
        "y" : 456
      },
      "to" : {
        "x" : 1233,
        "y" : 457
      }
    }, {
      "from" : {
        "x" : 1233,
        "y" : 457
      },
      "to" : {
        "x" : 1262,
        "y" : 455
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1227,
        "y" : 451
      },
      "b" : {
        "x" : 1239,
        "y" : 463
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1233,
        "y" : 457
      }
    },
    "inputs" : [ {
      "id" : 74845,
      "points" : [ {
        "x" : 1162,
        "y" : 458
      } ]
    }, {
      "id" : 74846,
      "points" : [ {
        "x" : 1176,
        "y" : 477
      } ]
    } ],
    "outputs" : [ {
      "id" : 74847,
      "points" : [ {
        "x" : 1283,
        "y" : 485
      } ]
    }, {
      "id" : 74848,
      "points" : [ {
        "x" : 1318,
        "y" : 460
      } ]
    } ],
    "catalysts" : [ {
      "id" : 74843,
      "points" : [ {
        "x" : 1245,
        "y" : 694
      } ]
    } ]
  }, {
    "id" : 74849,
    "reactomeId" : 10004098,
    "displayName" : "CSNK2-mediated phosphorylation of DVL",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 786,
      "y" : 719
    },
    "minX" : 762,
    "maxX" : 807,
    "minY" : 713,
    "maxY" : 725,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 762,
        "y" : 718
      },
      "to" : {
        "x" : 786,
        "y" : 719
      }
    }, {
      "from" : {
        "x" : 786,
        "y" : 719
      },
      "to" : {
        "x" : 807,
        "y" : 717
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 780,
        "y" : 713
      },
      "b" : {
        "x" : 792,
        "y" : 725
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 786,
        "y" : 719
      }
    },
    "inputs" : [ {
      "id" : 74850,
      "points" : [ {
        "x" : 745,
        "y" : 736
      } ]
    }, {
      "id" : 74851,
      "points" : [ {
        "x" : 712,
        "y" : 717
      } ]
    } ],
    "outputs" : [ {
      "id" : 74836,
      "points" : [ {
        "x" : 843,
        "y" : 717
      } ]
    }, {
      "id" : 74852,
      "points" : [ {
        "x" : 830,
        "y" : 733
      } ]
    } ],
    "catalysts" : [ {
      "id" : 74853,
      "points" : [ {
        "x" : 788,
        "y" : 779
      } ]
    } ]
  }, {
    "id" : 74854,
    "reactomeId" : 10049238,
    "displayName" : "CTNNBIP1 binds beta-catenin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2349,
      "y" : 1137
    },
    "minX" : 2304,
    "maxX" : 2374,
    "minY" : 1102,
    "maxY" : 1153,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2374,
        "y" : 1153
      },
      "to" : {
        "x" : 2349,
        "y" : 1137
      }
    }, {
      "from" : {
        "x" : 2349,
        "y" : 1137
      },
      "to" : {
        "x" : 2304,
        "y" : 1102
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2312,
        "y" : 1103
      },
      "b" : {
        "x" : 2304,
        "y" : 1102
      },
      "c" : {
        "x" : 2307,
        "y" : 1109
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2307,
        "y" : 1109
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2349,
        "y" : 1137
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2349,
        "y" : 1137
      }
    },
    "inputs" : [ {
      "id" : 74744,
      "points" : [ {
        "x" : 2468,
        "y" : 1198
      } ]
    }, {
      "id" : 74855,
      "points" : [ {
        "x" : 2358,
        "y" : 1169
      } ]
    } ],
    "outputs" : [ {
      "id" : 74856
    } ]
  }, {
    "id" : 74857,
    "reactomeId" : 10049136,
    "displayName" : "USP34 deubiquitinates AXIN1,AXIN2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1423,
      "y" : 1863
    },
    "minX" : 1350,
    "maxX" : 1469,
    "minY" : 1855,
    "maxY" : 1869,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1469,
        "y" : 1855
      },
      "to" : {
        "x" : 1423,
        "y" : 1863
      }
    }, {
      "from" : {
        "x" : 1423,
        "y" : 1863
      },
      "to" : {
        "x" : 1350,
        "y" : 1866
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1417,
        "y" : 1857
      },
      "b" : {
        "x" : 1429,
        "y" : 1869
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1423,
        "y" : 1863
      }
    },
    "inputs" : [ {
      "id" : 74858,
      "points" : [ {
        "x" : 1510,
        "y" : 1882
      } ]
    }, {
      "id" : 74795,
      "points" : [ {
        "x" : 1480,
        "y" : 1808
      } ]
    } ],
    "outputs" : [ {
      "id" : 74793,
      "points" : [ {
        "x" : 1213,
        "y" : 1815
      } ]
    }, {
      "id" : 74794,
      "points" : [ {
        "x" : 1249,
        "y" : 1714
      } ]
    } ],
    "catalysts" : [ {
      "id" : 74859,
      "points" : [ {
        "x" : 1435,
        "y" : 1903
      } ]
    } ]
  }, {
    "id" : 74860,
    "reactomeId" : 10051159,
    "displayName" : "DVL1 is bound by the HECT ubiquitin ligase HECW1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 547,
      "y" : 1143
    },
    "minX" : 541,
    "maxX" : 553,
    "minY" : 1126,
    "maxY" : 1171,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 546,
        "y" : 1126
      },
      "to" : {
        "x" : 547,
        "y" : 1143
      }
    }, {
      "from" : {
        "x" : 547,
        "y" : 1143
      },
      "to" : {
        "x" : 547,
        "y" : 1171
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 543,
        "y" : 1164
      },
      "b" : {
        "x" : 547,
        "y" : 1171
      },
      "c" : {
        "x" : 551,
        "y" : 1164
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 551,
        "y" : 1164
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 547,
        "y" : 1143
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 547,
        "y" : 1143
      }
    },
    "inputs" : [ {
      "id" : 74861,
      "points" : [ {
        "x" : 541,
        "y" : 1076
      } ]
    }, {
      "id" : 74862,
      "points" : [ {
        "x" : 611,
        "y" : 1095
      } ]
    } ],
    "outputs" : [ {
      "id" : 74863
    } ]
  }, {
    "id" : 74734,
    "reactomeId" : 10033692,
    "displayName" : "DVL recruits GSK3beta:AXIN1 to the receptor complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1532,
      "y" : 416
    },
    "minX" : 1507,
    "maxX" : 1565,
    "minY" : 410,
    "maxY" : 422,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1507,
        "y" : 413
      },
      "to" : {
        "x" : 1532,
        "y" : 416
      }
    }, {
      "from" : {
        "x" : 1532,
        "y" : 416
      },
      "to" : {
        "x" : 1565,
        "y" : 415
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1558,
        "y" : 419
      },
      "b" : {
        "x" : 1565,
        "y" : 415
      },
      "c" : {
        "x" : 1558,
        "y" : 411
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1558,
        "y" : 411
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1532,
        "y" : 416
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1532,
        "y" : 416
      }
    },
    "inputs" : [ {
      "id" : 74735,
      "points" : [ {
        "x" : 1435,
        "y" : 410
      } ]
    }, {
      "id" : 74736,
      "points" : [ {
        "x" : 1491,
        "y" : 486
      } ]
    } ],
    "outputs" : [ {
      "id" : 74737
    } ]
  }, {
    "id" : 74864,
    "reactomeId" : 10051164,
    "displayName" : "DVL1 is ubiquitinated by HECW1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 552,
      "y" : 1301
    },
    "minX" : 546,
    "maxX" : 558,
    "minY" : 1263,
    "maxY" : 1334,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 548,
        "y" : 1263
      },
      "to" : {
        "x" : 552,
        "y" : 1301
      }
    }, {
      "from" : {
        "x" : 552,
        "y" : 1301
      },
      "to" : {
        "x" : 552,
        "y" : 1334
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 548,
        "y" : 1327
      },
      "b" : {
        "x" : 552,
        "y" : 1334
      },
      "c" : {
        "x" : 556,
        "y" : 1327
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 556,
        "y" : 1327
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 546,
        "y" : 1295
      },
      "b" : {
        "x" : 558,
        "y" : 1307
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 552,
        "y" : 1301
      }
    },
    "inputs" : [ {
      "id" : 74863,
      "points" : [ {
        "x" : 548,
        "y" : 1213
      } ]
    }, {
      "id" : 74865,
      "points" : [ {
        "x" : 566,
        "y" : 1263
      } ]
    } ],
    "outputs" : [ {
      "id" : 74866
    } ],
    "catalysts" : [ {
      "id" : 74863,
      "points" : [ {
        "x" : 537,
        "y" : 1213
      }, {
        "x" : 518,
        "y" : 1244
      } ]
    } ]
  }, {
    "id" : 74867,
    "reactomeId" : 10051266,
    "displayName" : "Ubiquitinated DVL1 is degraded by the proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 662,
      "y" : 1352
    },
    "minX" : 603,
    "maxX" : 668,
    "minY" : 1308,
    "maxY" : 1358,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 603,
        "y" : 1353
      },
      "to" : {
        "x" : 662,
        "y" : 1352
      }
    }, {
      "from" : {
        "x" : 662,
        "y" : 1352
      },
      "to" : {
        "x" : 655,
        "y" : 1308
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 656,
        "y" : 1346
      },
      "b" : {
        "x" : 668,
        "y" : 1358
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 662,
        "y" : 1352
      }
    },
    "inputs" : [ {
      "id" : 74866
    } ],
    "outputs" : [ {
      "id" : 74862,
      "points" : [ {
        "x" : 642,
        "y" : 1100
      } ]
    }, {
      "id" : 74865,
      "points" : [ {
        "x" : 616,
        "y" : 1285
      } ]
    } ],
    "catalysts" : [ {
      "id" : 74749,
      "points" : [ {
        "x" : 880,
        "y" : 1352
      } ]
    } ]
  }, {
    "id" : 74738,
    "reactomeId" : 10033722,
    "displayName" : "DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 824,
      "y" : 1086
    },
    "minX" : 818,
    "maxX" : 830,
    "minY" : 1065,
    "maxY" : 1115,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 824,
        "y" : 1065
      },
      "to" : {
        "x" : 824,
        "y" : 1086
      }
    }, {
      "from" : {
        "x" : 824,
        "y" : 1086
      },
      "to" : {
        "x" : 825,
        "y" : 1115
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 821,
        "y" : 1108
      },
      "b" : {
        "x" : 825,
        "y" : 1115
      },
      "c" : {
        "x" : 829,
        "y" : 1108
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 829,
        "y" : 1108
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 824,
        "y" : 1086
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 824,
        "y" : 1086
      }
    },
    "inputs" : [ {
      "id" : 74739,
      "points" : [ {
        "x" : 895,
        "y" : 1084
      } ]
    }, {
      "id" : 74740,
      "points" : [ {
        "x" : 823,
        "y" : 1044
      } ]
    } ],
    "outputs" : [ {
      "id" : 74741
    } ]
  }, {
    "id" : 74868,
    "reactomeId" : 10051151,
    "displayName" : "DACT1 binds DVL2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1219,
      "y" : 967
    },
    "minX" : 1213,
    "maxX" : 1225,
    "minY" : 936,
    "maxY" : 1004,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1221,
        "y" : 936
      },
      "to" : {
        "x" : 1219,
        "y" : 967
      }
    }, {
      "from" : {
        "x" : 1219,
        "y" : 967
      },
      "to" : {
        "x" : 1219,
        "y" : 1004
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1215,
        "y" : 997
      },
      "b" : {
        "x" : 1219,
        "y" : 1004
      },
      "c" : {
        "x" : 1223,
        "y" : 997
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1223,
        "y" : 997
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1219,
        "y" : 967
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1219,
        "y" : 967
      }
    },
    "inputs" : [ {
      "id" : 74869,
      "points" : [ {
        "x" : 1251,
        "y" : 898
      } ]
    }, {
      "id" : 74870,
      "points" : [ {
        "x" : 1187,
        "y" : 897
      } ]
    } ],
    "outputs" : [ {
      "id" : 74871
    } ]
  }, {
    "id" : 74742,
    "reactomeId" : 10003923,
    "displayName" : "Beta-catenin translocates to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2203,
      "y" : 1202
    },
    "minX" : 1820,
    "maxX" : 2461,
    "minY" : 1187,
    "maxY" : 1213,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1820,
        "y" : 1187
      },
      "to" : {
        "x" : 2203,
        "y" : 1202
      }
    }, {
      "from" : {
        "x" : 2203,
        "y" : 1202
      },
      "to" : {
        "x" : 2461,
        "y" : 1213
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2454,
        "y" : 1217
      },
      "b" : {
        "x" : 2461,
        "y" : 1213
      },
      "c" : {
        "x" : 2454,
        "y" : 1209
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2454,
        "y" : 1209
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2197,
        "y" : 1196
      },
      "b" : {
        "x" : 2209,
        "y" : 1208
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2203,
        "y" : 1202
      }
    },
    "inputs" : [ {
      "id" : 74743
    } ],
    "outputs" : [ {
      "id" : 74744
    } ]
  }, {
    "id" : 74745,
    "reactomeId" : 10033718,
    "displayName" : "DVL is ubiquitinated by CUL3:KLHL12:RBX1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 830,
      "y" : 1214
    },
    "minX" : 824,
    "maxX" : 836,
    "minY" : 1184,
    "maxY" : 1252,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 830,
        "y" : 1184
      },
      "to" : {
        "x" : 830,
        "y" : 1214
      }
    }, {
      "from" : {
        "x" : 830,
        "y" : 1214
      },
      "to" : {
        "x" : 830,
        "y" : 1252
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 826,
        "y" : 1245
      },
      "b" : {
        "x" : 830,
        "y" : 1252
      },
      "c" : {
        "x" : 834,
        "y" : 1245
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 834,
        "y" : 1245
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 824,
        "y" : 1208
      },
      "b" : {
        "x" : 836,
        "y" : 1220
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 830,
        "y" : 1214
      }
    },
    "inputs" : [ {
      "id" : 74741,
      "points" : [ {
        "x" : 828,
        "y" : 1157
      } ]
    }, {
      "id" : 74746,
      "points" : [ {
        "x" : 855,
        "y" : 1184
      } ]
    } ],
    "outputs" : [ {
      "id" : 74747
    } ],
    "catalysts" : [ {
      "id" : 74741,
      "points" : [ {
        "x" : 804,
        "y" : 1157
      }, {
        "x" : 767,
        "y" : 1185
      } ]
    } ]
  }, {
    "id" : 74872,
    "reactomeId" : 10051143,
    "displayName" : "SMURF2 binds AXIN",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 725,
      "y" : 1573
    },
    "minX" : 693,
    "maxX" : 768,
    "minY" : 1567,
    "maxY" : 1579,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 693,
        "y" : 1573
      },
      "to" : {
        "x" : 725,
        "y" : 1573
      }
    }, {
      "from" : {
        "x" : 725,
        "y" : 1573
      },
      "to" : {
        "x" : 768,
        "y" : 1575
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 761,
        "y" : 1579
      },
      "b" : {
        "x" : 768,
        "y" : 1575
      },
      "c" : {
        "x" : 761,
        "y" : 1571
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 761,
        "y" : 1571
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 725,
        "y" : 1573
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 725,
        "y" : 1573
      }
    },
    "inputs" : [ {
      "id" : 74786,
      "points" : [ {
        "x" : 606,
        "y" : 1780
      } ]
    }, {
      "id" : 74873,
      "points" : [ {
        "x" : 632,
        "y" : 1570
      } ]
    } ],
    "outputs" : [ {
      "id" : 74874
    } ]
  }, {
    "id" : 74875,
    "reactomeId" : 10051141,
    "displayName" : "AXIN is ubiquitinated by SMURF2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 918,
      "y" : 1575
    },
    "minX" : 886,
    "maxX" : 947,
    "minY" : 1569,
    "maxY" : 1581,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 886,
        "y" : 1573
      },
      "to" : {
        "x" : 918,
        "y" : 1575
      }
    }, {
      "from" : {
        "x" : 918,
        "y" : 1575
      },
      "to" : {
        "x" : 947,
        "y" : 1575
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 940,
        "y" : 1579
      },
      "b" : {
        "x" : 947,
        "y" : 1575
      },
      "c" : {
        "x" : 940,
        "y" : 1571
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 940,
        "y" : 1571
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 912,
        "y" : 1569
      },
      "b" : {
        "x" : 924,
        "y" : 1581
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 918,
        "y" : 1575
      }
    },
    "inputs" : [ {
      "id" : 74874,
      "points" : [ {
        "x" : 848,
        "y" : 1575
      } ]
    }, {
      "id" : 74876,
      "points" : [ {
        "x" : 850,
        "y" : 1546
      } ]
    } ],
    "outputs" : [ {
      "id" : 74877
    } ],
    "catalysts" : [ {
      "id" : 74874,
      "points" : [ {
        "x" : 848,
        "y" : 1596
      }, {
        "x" : 884,
        "y" : 1616
      } ]
    } ]
  }, {
    "id" : 74748,
    "reactomeId" : 10033720,
    "displayName" : "Ubiquitinated DVL is degraded by the proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 927,
      "y" : 1284
    },
    "minX" : 879,
    "maxX" : 960,
    "minY" : 1278,
    "maxY" : 1290,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 879,
        "y" : 1278
      },
      "to" : {
        "x" : 927,
        "y" : 1284
      }
    }, {
      "from" : {
        "x" : 927,
        "y" : 1284
      },
      "to" : {
        "x" : 960,
        "y" : 1281
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 921,
        "y" : 1278
      },
      "b" : {
        "x" : 933,
        "y" : 1290
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 927,
        "y" : 1284
      }
    },
    "inputs" : [ {
      "id" : 74747
    } ],
    "outputs" : [ {
      "id" : 74739,
      "points" : [ {
        "x" : 954,
        "y" : 1128
      } ]
    }, {
      "id" : 74746,
      "points" : [ {
        "x" : 906,
        "y" : 1203
      } ]
    } ],
    "catalysts" : [ {
      "id" : 74749,
      "points" : [ {
        "x" : 934,
        "y" : 1332
      } ]
    } ]
  }, {
    "id" : 74879,
    "reactomeId" : 10051257,
    "displayName" : "ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 298,
      "y" : 1296
    },
    "minX" : 292,
    "maxX" : 304,
    "minY" : 1275,
    "maxY" : 1317,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 298,
        "y" : 1275
      },
      "to" : {
        "x" : 298,
        "y" : 1296
      }
    }, {
      "from" : {
        "x" : 298,
        "y" : 1296
      },
      "to" : {
        "x" : 297,
        "y" : 1317
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 293,
        "y" : 1310
      },
      "b" : {
        "x" : 297,
        "y" : 1317
      },
      "c" : {
        "x" : 301,
        "y" : 1310
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 301,
        "y" : 1310
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 298,
        "y" : 1296
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 298,
        "y" : 1296
      }
    },
    "inputs" : [ {
      "id" : 74880,
      "points" : [ {
        "x" : 298,
        "y" : 1256
      } ]
    }, {
      "id" : 74881,
      "points" : [ {
        "x" : 137,
        "y" : 1093
      }, {
        "x" : 181,
        "y" : 1266
      } ]
    } ],
    "outputs" : [ {
      "id" : 74882
    } ]
  }, {
    "id" : 74750,
    "reactomeId" : 10004019,
    "displayName" : "Beta-catenin is released from the destruction complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1686,
      "y" : 1165
    },
    "minX" : 1680,
    "maxX" : 1692,
    "minY" : 1096,
    "maxY" : 1196,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 1686,
        "y" : 1096
      },
      "to" : {
        "x" : 1686,
        "y" : 1165
      }
    }, {
      "from" : {
        "x" : 1686,
        "y" : 1165
      },
      "to" : {
        "x" : 1682,
        "y" : 1196
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1686,
        "y" : 1165
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 1686,
        "y" : 1165
      }
    },
    "inputs" : [ {
      "id" : 74751
    } ],
    "outputs" : [ {
      "id" : 74752,
      "points" : [ {
        "x" : 1601,
        "y" : 1253
      } ]
    }, {
      "id" : 74753,
      "points" : [ {
        "x" : 1740,
        "y" : 1236
      } ]
    }, {
      "id" : 74743,
      "points" : [ {
        "x" : 1735,
        "y" : 1190
      } ]
    }, {
      "id" : 74754,
      "points" : [ {
        "x" : 1613,
        "y" : 1204
      } ]
    }, {
      "id" : 74755,
      "points" : [ {
        "x" : 1684,
        "y" : 1251
      } ]
    }, {
      "id" : 74736,
      "points" : [ {
        "x" : 1490,
        "y" : 528
      }, {
        "x" : 1558,
        "y" : 1118
      } ]
    } ],
    "activators" : [ {
      "id" : 74756,
      "points" : [ {
        "x" : 2321,
        "y" : 457
      }, {
        "x" : 1933,
        "y" : 917
      }, {
        "x" : 1905,
        "y" : 1036
      } ]
    } ]
  }, {
    "id" : 74878,
    "reactomeId" : 10051264,
    "displayName" : "Ubiquitinated AXIN is degraded by the proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 972,
      "y" : 1482
    },
    "minX" : 844,
    "maxX" : 995,
    "minY" : 1476,
    "maxY" : 1551,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 995,
        "y" : 1551
      },
      "to" : {
        "x" : 972,
        "y" : 1482
      }
    }, {
      "from" : {
        "x" : 972,
        "y" : 1482
      },
      "to" : {
        "x" : 844,
        "y" : 1487
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 966,
        "y" : 1476
      },
      "b" : {
        "x" : 978,
        "y" : 1488
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 972,
        "y" : 1482
      }
    },
    "inputs" : [ {
      "id" : 74877
    } ],
    "outputs" : [ {
      "id" : 74873,
      "points" : [ {
        "x" : 632,
        "y" : 1560
      } ]
    }, {
      "id" : 74876,
      "points" : [ {
        "x" : 840,
        "y" : 1512
      } ]
    } ],
    "catalysts" : [ {
      "id" : 74749,
      "points" : [ {
        "x" : 941,
        "y" : 1374
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 74944,
    "reactomeId" : 171043,
    "displayName" : "early endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2503,
      "y" : 589
    },
    "minX" : 2391,
    "maxX" : 2616,
    "minY" : 533,
    "maxY" : 646,
    "prop" : {
      "x" : 2391,
      "y" : 533,
      "width" : 225,
      "height" : 113
    },
    "textPosition" : {
      "x" : 2415,
      "y" : 578
    },
    "insets" : {
      "x" : 2401,
      "y" : 543,
      "width" : 205,
      "height" : 93
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 74912 ]
  }, {
    "id" : 74925,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 3013,
      "y" : 1293
    },
    "minX" : 2071,
    "maxX" : 3955,
    "minY" : 761,
    "maxY" : 1825,
    "prop" : {
      "x" : 2071,
      "y" : 761,
      "width" : 1884,
      "height" : 1064
    },
    "textPosition" : {
      "x" : 3676,
      "y" : 1552
    },
    "insets" : {
      "x" : 2081,
      "y" : 771,
      "width" : 1864,
      "height" : 1044
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 74742, 74761, 74765, 74766, 74767, 74762, 74763, 74764, 74768, 74769, 74800, 74801, 74804, 74803, 74810, 74771, 74772, 74774, 74776, 74775, 74770, 74773, 74777, 74778, 74779, 74780, 74783, 74781, 74807, 74806, 74808, 74744, 74799, 74802, 74805, 74809, 74811, 74812, 74813, 74814, 74817, 74816, 74815, 74818, 74819, 74820, 74821, 74822, 74823, 74824, 74854, 74856, 74855, 74908, 74909, 74915, 74917, 74916, 74918, 74919, 74962, 74920, 74782 ]
  }, {
    "id" : 74924,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2171,
      "y" : 1193
    },
    "minX" : 194,
    "maxX" : 4149,
    "minY" : 380,
    "maxY" : 2007,
    "prop" : {
      "x" : 194,
      "y" : 380,
      "width" : 3955,
      "height" : 1627
    },
    "textPosition" : {
      "x" : 1667,
      "y" : 1458
    },
    "insets" : {
      "x" : 204,
      "y" : 390,
      "width" : 3935,
      "height" : 1607
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 74741, 74738, 74736, 74735, 74740, 74746, 74745, 74748, 74737, 74925, 74749, 74757, 74760, 74756, 74759, 74758, 74750, 74755, 74753, 74754, 74784, 74785, 74786, 74787, 74789, 74788, 74791, 74794, 74796, 74793, 74792, 74797, 74795, 74798, 74825, 74826, 74830, 74827, 74839, 74835, 74836, 74837, 74838, 74842, 74843, 74844, 74845, 74846, 74847, 74848, 74841, 74739, 74734, 74831, 74849, 74850, 74851, 74953, 74852, 74853, 74743, 74790, 74857, 74859, 74858, 74840, 74954, 74942, 74751, 74860, 74861, 74955, 74956, 74862, 74863, 74864, 74866, 74865, 74867, 74868, 74869, 74870, 74957, 74958, 74871, 74872, 74873, 74874, 74875, 74877, 74876, 74878, 74828, 74879, 74880, 74882, 74885, 74883, 74884, 74886, 74887, 74888, 74889, 74891, 74890, 74893, 74895, 74894, 74896, 74898, 74897, 74747, 74899, 74900, 74902, 74903, 74904, 74906, 74943, 74944, 74752, 74910, 74911, 74913, 74905, 74907, 74945, 74946, 74963 ]
  }, {
    "id" : 74943,
    "reactomeId" : 171043,
    "displayName" : "early endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 508,
      "y" : 630
    },
    "minX" : 369,
    "maxX" : 647,
    "minY" : 579,
    "maxY" : 681,
    "prop" : {
      "x" : 369,
      "y" : 579,
      "width" : 278,
      "height" : 102
    },
    "textPosition" : {
      "x" : 422,
      "y" : 627
    },
    "insets" : {
      "x" : 379,
      "y" : 589,
      "width" : 258,
      "height" : 82
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 74914 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 74960,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 101,
      "y" : 380
    },
    "minX" : 76,
    "maxX" : 126,
    "minY" : 264,
    "maxY" : 497,
    "segments" : [ {
      "from" : {
        "x" : 76,
        "y" : 497
      },
      "to" : {
        "x" : 126,
        "y" : 264
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 95,
        "y" : 374
      },
      "b" : {
        "x" : 107,
        "y" : 386
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 101,
        "y" : 380
      }
    },
    "inputs" : [ {
      "id" : 74901
    } ],
    "outputs" : [ {
      "id" : 74923
    } ]
  }, {
    "id" : 74963,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1685,
      "y" : 789
    },
    "minX" : 1679,
    "maxX" : 1691,
    "minY" : 757,
    "maxY" : 822,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1685,
        "y" : 757
      },
      "to" : {
        "x" : 1686,
        "y" : 822
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1682,
        "y" : 815
      },
      "b" : {
        "x" : 1686,
        "y" : 822
      },
      "c" : {
        "x" : 1690,
        "y" : 815
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1690,
        "y" : 815
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1679,
        "y" : 783
      },
      "b" : {
        "x" : 1691,
        "y" : 795
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1685,
        "y" : 789
      }
    },
    "inputs" : [ {
      "id" : 74946
    } ],
    "outputs" : [ {
      "id" : 74945
    } ]
  }, {
    "id" : 74962,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 2265,
      "y" : 1332
    },
    "minX" : 2254,
    "maxX" : 2277,
    "minY" : 1275,
    "maxY" : 1390,
    "segments" : [ {
      "from" : {
        "x" : 2277,
        "y" : 1390
      },
      "to" : {
        "x" : 2254,
        "y" : 1275
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2259,
        "y" : 1326
      },
      "b" : {
        "x" : 2271,
        "y" : 1338
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2265,
        "y" : 1332
      }
    },
    "inputs" : [ {
      "id" : 74919
    } ],
    "outputs" : [ {
      "id" : 74916
    } ]
  }, {
    "id" : 74949,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 192,
      "y" : 158
    },
    "minX" : 144,
    "maxX" : 241,
    "minY" : 100,
    "maxY" : 216,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 241,
        "y" : 100
      },
      "to" : {
        "x" : 144,
        "y" : 216
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 145,
        "y" : 208
      },
      "b" : {
        "x" : 144,
        "y" : 216
      },
      "c" : {
        "x" : 152,
        "y" : 213
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 152,
        "y" : 213
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 186,
        "y" : 152
      },
      "b" : {
        "x" : 198,
        "y" : 164
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 192,
        "y" : 158
      }
    },
    "inputs" : [ {
      "id" : 74938
    } ],
    "outputs" : [ {
      "id" : 74923
    } ]
  }, {
    "id" : 74951,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 307,
      "y" : 168
    },
    "minX" : 176,
    "maxX" : 439,
    "minY" : 121,
    "maxY" : 216,
    "segments" : [ {
      "from" : {
        "x" : 439,
        "y" : 121
      },
      "to" : {
        "x" : 176,
        "y" : 216
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 301,
        "y" : 162
      },
      "b" : {
        "x" : 313,
        "y" : 174
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 307,
        "y" : 168
      }
    },
    "inputs" : [ {
      "id" : 74939
    } ],
    "outputs" : [ {
      "id" : 74923
    } ]
  }, {
    "id" : 74953,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 679,
      "y" : 933
    },
    "minX" : 673,
    "maxX" : 806,
    "minY" : 733,
    "maxY" : 1010,
    "segments" : [ {
      "from" : {
        "x" : 681,
        "y" : 733
      },
      "to" : {
        "x" : 679,
        "y" : 933
      }
    }, {
      "from" : {
        "x" : 679,
        "y" : 933
      },
      "to" : {
        "x" : 806,
        "y" : 1010
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 673,
        "y" : 927
      },
      "b" : {
        "x" : 685,
        "y" : 939
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 679,
        "y" : 933
      }
    },
    "inputs" : [ {
      "id" : 74851
    } ],
    "outputs" : [ {
      "id" : 74740
    } ]
  }, {
    "id" : 74955,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 611,
      "y" : 888
    },
    "minX" : 545,
    "maxX" : 678,
    "minY" : 733,
    "maxY" : 1043,
    "segments" : [ {
      "from" : {
        "x" : 545,
        "y" : 1043
      },
      "to" : {
        "x" : 678,
        "y" : 733
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 605,
        "y" : 882
      },
      "b" : {
        "x" : 617,
        "y" : 894
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 611,
        "y" : 888
      }
    },
    "inputs" : [ {
      "id" : 74861
    } ],
    "outputs" : [ {
      "id" : 74851
    } ]
  }, {
    "id" : 74954,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 743,
      "y" : 1950
    },
    "minX" : 612,
    "maxX" : 2501,
    "minY" : 1814,
    "maxY" : 1956,
    "segments" : [ {
      "from" : {
        "x" : 2501,
        "y" : 1939
      },
      "to" : {
        "x" : 743,
        "y" : 1950
      }
    }, {
      "from" : {
        "x" : 743,
        "y" : 1950
      },
      "to" : {
        "x" : 612,
        "y" : 1814
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 737,
        "y" : 1944
      },
      "b" : {
        "x" : 749,
        "y" : 1956
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 743,
        "y" : 1950
      }
    },
    "inputs" : [ {
      "id" : 74942
    } ],
    "outputs" : [ {
      "id" : 74786
    } ]
  }, {
    "id" : 74957,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 714,
      "y" : 896
    },
    "minX" : 683,
    "maxX" : 1149,
    "minY" : 733,
    "maxY" : 902,
    "segments" : [ {
      "from" : {
        "x" : 1149,
        "y" : 883
      },
      "to" : {
        "x" : 714,
        "y" : 896
      }
    }, {
      "from" : {
        "x" : 714,
        "y" : 896
      },
      "to" : {
        "x" : 683,
        "y" : 733
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 708,
        "y" : 890
      },
      "b" : {
        "x" : 720,
        "y" : 902
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 714,
        "y" : 896
      }
    },
    "inputs" : [ {
      "id" : 74870
    } ],
    "outputs" : [ {
      "id" : 74851
    } ]
  }, {
    "id" : 74956,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 672,
      "y" : 1043
    },
    "minX" : 569,
    "maxX" : 776,
    "minY" : 1031,
    "maxY" : 1055,
    "segments" : [ {
      "from" : {
        "x" : 569,
        "y" : 1055
      },
      "to" : {
        "x" : 776,
        "y" : 1031
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 666,
        "y" : 1037
      },
      "b" : {
        "x" : 678,
        "y" : 1049
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 672,
        "y" : 1043
      }
    },
    "inputs" : [ {
      "id" : 74861
    } ],
    "outputs" : [ {
      "id" : 74740
    } ]
  }, {
    "id" : 74959,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 281,
      "y" : 309
    },
    "minX" : 90,
    "maxX" : 472,
    "minY" : 121,
    "maxY" : 497,
    "segments" : [ {
      "from" : {
        "x" : 472,
        "y" : 121
      },
      "to" : {
        "x" : 90,
        "y" : 497
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 275,
        "y" : 303
      },
      "b" : {
        "x" : 287,
        "y" : 315
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 281,
        "y" : 309
      }
    },
    "inputs" : [ {
      "id" : 74939
    } ],
    "outputs" : [ {
      "id" : 74901
    } ]
  }, {
    "id" : 74958,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 999,
      "y" : 951
    },
    "minX" : 849,
    "maxX" : 1149,
    "minY" : 893,
    "maxY" : 1010,
    "segments" : [ {
      "from" : {
        "x" : 1149,
        "y" : 893
      },
      "to" : {
        "x" : 849,
        "y" : 1010
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 993,
        "y" : 945
      },
      "b" : {
        "x" : 1005,
        "y" : 957
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 999,
        "y" : 951
      }
    },
    "inputs" : [ {
      "id" : 74870
    } ],
    "outputs" : [ {
      "id" : 74740
    } ]
  } ],
  "shadows" : [ {
    "id" : 74965,
    "reactomeId" : 10099793,
    "displayName" : "Formation of the beta-catenin:TCF transactivating complex",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 2840,
      "y" : 1188
    },
    "minX" : 2398,
    "maxX" : 3282,
    "minY" : 1000,
    "maxY" : 1376,
    "prop" : {
      "x" : 2599,
      "y" : 1000,
      "width" : 683,
      "height" : 293
    },
    "points" : [ {
      "x" : 2398,
      "y" : 1000
    }, {
      "x" : 3282,
      "y" : 1000
    }, {
      "x" : 3282,
      "y" : 1376
    }, {
      "x" : 2398,
      "y" : 1376
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 74964,
    "reactomeId" : 10099791,
    "displayName" : "Disassembly of the destruction complex and recruitment of AXIN to the membrane",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1954,
      "y" : 833
    },
    "minX" : 1309,
    "maxX" : 2599,
    "minY" : 374,
    "maxY" : 1293,
    "prop" : {
      "x" : 1309,
      "y" : 818,
      "width" : 873,
      "height" : 475
    },
    "points" : [ {
      "x" : 1309,
      "y" : 374
    }, {
      "x" : 2599,
      "y" : 374
    }, {
      "x" : 2599,
      "y" : 1293
    }, {
      "x" : 1309,
      "y" : 1293
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 74967,
    "reactomeId" : 10100739,
    "displayName" : "Degradation of DVL",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 896,
      "y" : 1122
    },
    "minX" : 492,
    "maxX" : 1301,
    "minY" : 861,
    "maxY" : 1384,
    "prop" : {
      "x" : 492,
      "y" : 861,
      "width" : 809,
      "height" : 464
    },
    "points" : [ {
      "x" : 492,
      "y" : 861
    }, {
      "x" : 1301,
      "y" : 861
    }, {
      "x" : 1301,
      "y" : 1384
    }, {
      "x" : 492,
      "y" : 1384
    } ],
    "colour" : "#666666"
  }, {
    "id" : 74966,
    "reactomeId" : 10099795,
    "displayName" : "WNT mediated activation of DVL",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1026,
      "y" : 626
    },
    "minX" : 649,
    "maxX" : 1403,
    "minY" : 435,
    "maxY" : 818,
    "prop" : {
      "x" : 649,
      "y" : 617,
      "width" : 660,
      "height" : 201
    },
    "points" : [ {
      "x" : 649,
      "y" : 435
    }, {
      "x" : 1403,
      "y" : 435
    }, {
      "x" : 1403,
      "y" : 818
    }, {
      "x" : 649,
      "y" : 818
    } ],
    "colour" : "#008000"
  }, {
    "id" : 74969,
    "reactomeId" : 10101045,
    "displayName" : "Degradation of AXIN",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1060,
      "y" : 1597
    },
    "minX" : 560,
    "maxX" : 1561,
    "minY" : 1325,
    "maxY" : 1870,
    "prop" : {
      "x" : 560,
      "y" : 1384,
      "width" : 1001,
      "height" : 486
    },
    "points" : [ {
      "x" : 560,
      "y" : 1325
    }, {
      "x" : 1561,
      "y" : 1325
    }, {
      "x" : 1561,
      "y" : 1870
    }, {
      "x" : 560,
      "y" : 1870
    } ],
    "colour" : "#cb4ac5"
  }, {
    "id" : 74968,
    "reactomeId" : 10101021,
    "displayName" : "Deactivation of the beta-catenin transactivating complex",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 2983,
      "y" : 1089
    },
    "minX" : 2182,
    "maxX" : 3784,
    "minY" : 599,
    "maxY" : 1579,
    "prop" : {
      "x" : 2599,
      "y" : 599,
      "width" : 1185,
      "height" : 401
    },
    "points" : [ {
      "x" : 2182,
      "y" : 599
    }, {
      "x" : 3784,
      "y" : 599
    }, {
      "x" : 3784,
      "y" : 1579
    }, {
      "x" : 2182,
      "y" : 1579
    } ],
    "colour" : "#4942cc"
  }, {
    "id" : 74971,
    "reactomeId" : 10101079,
    "displayName" : "Regulation of FZD by ubiquitination",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 272,
      "y" : 1132
    },
    "minX" : 65,
    "maxX" : 479,
    "minY" : 725,
    "maxY" : 1540,
    "prop" : {
      "x" : 65,
      "y" : 725,
      "width" : 414,
      "height" : 815
    },
    "points" : [ {
      "x" : 65,
      "y" : 725
    }, {
      "x" : 479,
      "y" : 725
    }, {
      "x" : 479,
      "y" : 1540
    }, {
      "x" : 65,
      "y" : 1540
    } ],
    "colour" : "#336699"
  }, {
    "id" : 74970,
    "reactomeId" : 10101047,
    "displayName" : "Negative regulation of TCF-dependent signaling by WNT ligand antagonists",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 507,
      "y" : 439
    },
    "minX" : 319,
    "maxX" : 696,
    "minY" : 262,
    "maxY" : 617,
    "prop" : {
      "x" : 319,
      "y" : 262,
      "width" : 377,
      "height" : 173
    },
    "points" : [ {
      "x" : 319,
      "y" : 262
    }, {
      "x" : 696,
      "y" : 262
    }, {
      "x" : 696,
      "y" : 617
    }, {
      "x" : 319,
      "y" : 617
    } ],
    "colour" : "#d6ae00"
  } ],
  "minX" : 0,
  "maxX" : 4149,
  "minY" : 0,
  "maxY" : 2007,
  "disease" : false
}