{ "dbId" : 9958825, "stableId" : "R-HSA-9958825", "displayName" : "Activation of STAT3 by cadherin engagement", "nodes" : [ { "id" : 3, "reactomeId" : 197824, "displayName" : "IL6R", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 775, "y" : 272 }, "minX" : 755, "maxX" : 802, "minY" : 80, "maxY" : 284, "prop" : { "x" : 755, "y" : 261, "width" : 41, "height" : 23 }, "textPosition" : { "x" : 759, "y" : 262 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 796, "y" : 261 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 796, "y" : 261 } } }, "connectors" : [ { "edgeId" : 2, "type" : "INPUT", "segments" : [ { "from" : { "x" : 775, "y" : 258 }, "to" : { "x" : 776, "y" : 80 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 4, "reactomeId" : 447100, "displayName" : "IL6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 670, "y" : 222 }, "minX" : 641, "maxX" : 776, "minY" : 80, "maxY" : 231, "prop" : { "x" : 646, "y" : 213, "width" : 48, "height" : 18 }, "textPosition" : { "x" : 657, "y" : 212 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 694, "y" : 213 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 694, "y" : 213 } } }, "connectors" : [ { "edgeId" : 2, "type" : "INPUT", "segments" : [ { "from" : { "x" : 667, "y" : 210 }, "to" : { "x" : 641, "y" : 119 } }, { "from" : { "x" : 641, "y" : 119 }, "to" : { "x" : 776, "y" : 80 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 6, "type" : "INPUT", "segments" : [ { "from" : { "x" : 697, "y" : 217 }, "to" : { "x" : 731, "y" : 210 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 3157, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5, "reactomeId" : 1067638, "displayName" : "IL6:IL6R", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 870, "y" : 265 }, "minX" : 836, "maxX" : 1000, "minY" : 213, "maxY" : 276, "prop" : { "x" : 836, "y" : 254, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 843, "y" : 255 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 905, "y" : 254 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 905, "y" : 254 } } }, "connectors" : [ { "edgeId" : 2, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 9, "type" : "INPUT", "segments" : [ { "from" : { "x" : 897, "y" : 251 }, "to" : { "x" : 1000, "y" : 213 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 7, "reactomeId" : 1067661, "displayName" : "IL6R-2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 700, "y" : 164 }, "minX" : 677, "maxX" : 731, "minY" : 147, "maxY" : 210, "prop" : { "x" : 677, "y" : 153, "width" : 47, "height" : 22 }, "textPosition" : { "x" : 678, "y" : 153 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 724, "y" : 153 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 724, "y" : 153 } } }, "connectors" : [ { "edgeId" : 6, "type" : "INPUT", "segments" : [ { "from" : { "x" : 707, "y" : 178 }, "to" : { "x" : 731, "y" : 210 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 4999, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 664, "y" : 1054 }, "minX" : 644, "maxX" : 714, "minY" : 1041, "maxY" : 1104, "prop" : { "x" : 644, "y" : 1042, "width" : 40, "height" : 25 }, "textPosition" : { "x" : 648, "y" : 1044 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 679, "y" : 1047 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 679, "y" : 1047 } } }, "connectors" : [ { "edgeId" : 4998, "type" : "INPUT", "segments" : [ { "from" : { "x" : 676, "y" : 1070 }, "to" : { "x" : 714, "y" : 1104 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 136, "reactomeId" : 539044, "displayName" : "STAT3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2017, "y" : 426 }, "minX" : 1992, "maxX" : 2067, "minY" : 394, "maxY" : 438, "prop" : { "x" : 1992, "y" : 415, "width" : 51, "height" : 23 }, "textPosition" : { "x" : 1994, "y" : 416 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2043, "y" : 415 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2043, "y" : 415 } } }, "connectors" : [ { "edgeId" : 135, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2034, "y" : 412 }, "to" : { "x" : 2067, "y" : 394 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8, "reactomeId" : 1067687, "displayName" : "IL6:IL6R-2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 826, "y" : 166 }, "minX" : 789, "maxX" : 943, "minY" : 149, "maxY" : 204, "prop" : { "x" : 789, "y" : 155, "width" : 75, "height" : 22 }, "textPosition" : { "x" : 793, "y" : 156 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 864, "y" : 155 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 864, "y" : 155 } } }, "connectors" : [ { "edgeId" : 6, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 12, "type" : "INPUT", "segments" : [ { "from" : { "x" : 859, "y" : 180 }, "to" : { "x" : 943, "y" : 204 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 137, "reactomeId" : 9958926, "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2072, "y" : 572 }, "minX" : 2002, "maxX" : 2149, "minY" : 534, "maxY" : 679, "prop" : { "x" : 2002, "y" : 540, "width" : 141, "height" : 65 }, "textPosition" : { "x" : 2004, "y" : 542 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2143, "y" : 540 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2143, "y" : 540 } } }, "connectors" : [ { "edgeId" : 135, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 168, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2082, "y" : 608 }, "to" : { "x" : 2095, "y" : 645 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 168, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2093, "y" : 608 }, "to" : { "x" : 2138, "y" : 673 } }, { "from" : { "x" : 2138, "y" : 673 }, "to" : { "x" : 2110, "y" : 675 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2106, "y" : 675 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2106, "y" : 675 } } } ] }, { "id" : 10, "reactomeId" : 1067690, "displayName" : "IL6ST:JAK1, JAK2, (TYK2)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 992, "y" : 287 }, "minX" : 943, "maxX" : 1025, "minY" : 204, "maxY" : 318, "prop" : { "x" : 965, "y" : 256, "width" : 54, "height" : 62 }, "textPosition" : { "x" : 968, "y" : 255 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1019, "y" : 256 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1019, "y" : 256 } } }, "connectors" : [ { "edgeId" : 9, "type" : "INPUT", "segments" : [ { "from" : { "x" : 995, "y" : 253 }, "to" : { "x" : 1000, "y" : 213 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 12, "type" : "INPUT", "segments" : [ { "from" : { "x" : 973, "y" : 253 }, "to" : { "x" : 943, "y" : 204 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 3295, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 11, "reactomeId" : 1067654, "displayName" : "IL6:IL6RA:IL6RB:JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1097, "y" : 308 }, "minX" : 1056, "maxX" : 1144, "minY" : 285, "maxY" : 326, "prop" : { "x" : 1056, "y" : 291, "width" : 82, "height" : 35 }, "textPosition" : { "x" : 1062, "y" : 291 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1138, "y" : 291 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1138, "y" : 291 } } }, "connectors" : [ { "edgeId" : 9, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 3084, "reactomeId" : 9968091, "displayName" : "SRC targeted RAC1/CDC42 GEFs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 798, "y" : 1427 }, "minX" : 656, "maxX" : 849, "minY" : 1405, "maxY" : 1450, "prop" : { "x" : 748, "y" : 1405, "width" : 101, "height" : 45 }, "textPosition" : { "x" : 751, "y" : 1403 }, "connectors" : [ { "edgeId" : 3083, "type" : "INPUT", "segments" : [ { "from" : { "x" : 742, "y" : 1427 }, "to" : { "x" : 656, "y" : 1427 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13, "reactomeId" : 1067691, "displayName" : "IL6:sIL6R:IL6RB:JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1191, "y" : 308 }, "minX" : 1156, "maxX" : 1233, "minY" : 283, "maxY" : 327, "prop" : { "x" : 1156, "y" : 289, "width" : 71, "height" : 38 }, "textPosition" : { "x" : 1156, "y" : 292 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1227, "y" : 289 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1227, "y" : 289 } } }, "connectors" : [ { "edgeId" : 12, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 3085, "reactomeId" : 9968090, "displayName" : "SRC-phosphorylated RAC1/CDC42 GEFs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 741, "y" : 1191 }, "minX" : 688, "maxX" : 794, "minY" : 1053, "maxY" : 1302, "prop" : { "x" : 688, "y" : 1162, "width" : 106, "height" : 59 }, "textPosition" : { "x" : 686, "y" : 1160 }, "connectors" : [ { "edgeId" : 4998, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 736, "y" : 1156 }, "to" : { "x" : 720, "y" : 1061 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 719, "y" : 1057 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 719, "y" : 1057 } } }, { "edgeId" : 3083, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 741, "y" : 1227 }, "to" : { "x" : 744, "y" : 1302 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 745, "y" : 1234 }, "b" : { "x" : 741, "y" : 1227 }, "c" : { "x" : 737, "y" : 1234 }, "type" : "ARROW", "centre" : { "x" : 737, "y" : 1234 } } } ] }, { "id" : 5133, "reactomeId" : 191697, "displayName" : "CTNNA1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 712, "y" : 836 }, "minX" : 574, "maxX" : 749, "minY" : 819, "maxY" : 850, "prop" : { "x" : 682, "y" : 825, "width" : 61, "height" : 23 }, "textPosition" : { "x" : 684, "y" : 826 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 743, "y" : 825 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 743, "y" : 825 } } }, "connectors" : [ { "edgeId" : 2732, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 679, "y" : 839 }, "to" : { "x" : 574, "y" : 850 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 673, "y" : 844 }, "b" : { "x" : 679, "y" : 839 }, "c" : { "x" : 672, "y" : 836 }, "type" : "ARROW", "centre" : { "x" : 672, "y" : 836 } } } ] }, { "id" : 3086, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 673, "y" : 1332 }, "minX" : 653, "maxX" : 695, "minY" : 1321, "maxY" : 1427, "prop" : { "x" : 653, "y" : 1322, "width" : 41, "height" : 21 }, "textPosition" : { "x" : 658, "y" : 1322 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 689, "y" : 1327 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 689, "y" : 1327 } } }, "connectors" : [ { "edgeId" : 3083, "type" : "INPUT", "segments" : [ { "from" : { "x" : 671, "y" : 1346 }, "to" : { "x" : 656, "y" : 1427 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1422, "reactomeId" : 9959465, "displayName" : "Ub-RAC1:GTP,(Ub-CDC42:GTP)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 554, "y" : 474 }, "minX" : 503, "maxX" : 605, "minY" : 456, "maxY" : 492, "prop" : { "x" : 503, "y" : 456, "width" : 102, "height" : 36 }, "textPosition" : { "x" : 507, "y" : 450 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 3138, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1441, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5135, "reactomeId" : 418996, "displayName" : "CTNND1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 540, "y" : 902 }, "minX" : 511, "maxX" : 575, "minY" : 850, "maxY" : 914, "prop" : { "x" : 511, "y" : 891, "width" : 58, "height" : 23 }, "textPosition" : { "x" : 511, "y" : 892 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 569, "y" : 891 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 569, "y" : 891 } } }, "connectors" : [ { "edgeId" : 2732, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 547, "y" : 888 }, "to" : { "x" : 574, "y" : 850 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 548, "y" : 880 }, "b" : { "x" : 547, "y" : 888 }, "c" : { "x" : 554, "y" : 885 }, "type" : "ARROW", "centre" : { "x" : 554, "y" : 885 } } } ] }, { "id" : 1423, "reactomeId" : 9959457, "displayName" : "RAC1,(CDC42) Ubiquitin Ligase", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 663, "y" : 606 }, "minX" : 583, "maxX" : 701, "minY" : 574, "maxY" : 638, "prop" : { "x" : 626, "y" : 574, "width" : 75, "height" : 64 }, "textPosition" : { "x" : 630, "y" : 574 }, "connectors" : [ { "edgeId" : 3138, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 620, "y" : 612 }, "to" : { "x" : 591, "y" : 619 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 587, "y" : 619 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 587, "y" : 619 } } } ] }, { "id" : 399, "reactomeId" : 113595, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 637, "y" : 1922 }, "minX" : 408, "maxX" : 656, "minY" : 1911, "maxY" : 1988, "prop" : { "x" : 618, "y" : 1911, "width" : 38, "height" : 23 }, "textPosition" : { "x" : 624, "y" : 1912 }, "connectors" : [ { "edgeId" : 398, "type" : "INPUT", "segments" : [ { "from" : { "x" : 612, "y" : 1927 }, "to" : { "x" : 408, "y" : 1988 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 504, "y" : 1951 }, "b" : { "x" : 516, "y" : 1963 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 510, "y" : 1957 } } } } ] }, { "id" : 3087, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 813, "y" : 1256 }, "minX" : 744, "maxX" : 836, "minY" : 1245, "maxY" : 1302, "prop" : { "x" : 792, "y" : 1246, "width" : 43, "height" : 20 }, "textPosition" : { "x" : 797, "y" : 1246 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 830, "y" : 1251 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 830, "y" : 1251 } } }, "connectors" : [ { "edgeId" : 3083, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 798, "y" : 1269 }, "to" : { "x" : 744, "y" : 1302 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 794, "y" : 1276 }, "b" : { "x" : 798, "y" : 1269 }, "c" : { "x" : 790, "y" : 1269 }, "type" : "ARROW", "centre" : { "x" : 790, "y" : 1269 } } } ] }, { "id" : 15, "reactomeId" : 1112523, "displayName" : "IL6 receptor trimer:JAKs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1370, "y" : 293 }, "minX" : 1320, "maxX" : 1464, "minY" : 276, "maxY" : 310, "prop" : { "x" : 1320, "y" : 276, "width" : 100, "height" : 34 }, "textPosition" : { "x" : 1326, "y" : 276 }, "connectors" : [ { "edgeId" : 14, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1452, "y" : 290 }, "b" : { "x" : 1464, "y" : 302 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1458, "y" : 296 } } } } ] }, { "id" : 400, "reactomeId" : 9935237, "displayName" : "CBLL1:PolyUb-p-2Y-CDH1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 418, "y" : 2079 }, "minX" : 340, "maxX" : 503, "minY" : 2060, "maxY" : 2093, "prop" : { "x" : 340, "y" : 2066, "width" : 157, "height" : 27 }, "textPosition" : { "x" : 356, "y" : 2058 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 497, "y" : 2066 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 497, "y" : 2066 } } }, "connectors" : [ { "edgeId" : 398, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 401, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 16, "reactomeId" : 1112588, "displayName" : "IL6 receptor hexamer:JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1604, "y" : 300 }, "minX" : 1555, "maxX" : 1685, "minY" : 275, "maxY" : 319, "prop" : { "x" : 1555, "y" : 281, "width" : 99, "height" : 38 }, "textPosition" : { "x" : 1559, "y" : 284 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1654, "y" : 281 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1654, "y" : 281 } } }, "connectors" : [ { "edgeId" : 14, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 19, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1657, "y" : 295 }, "to" : { "x" : 1685, "y" : 293 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1425, "reactomeId" : 113595, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 653, "y" : 366 }, "minX" : 634, "maxX" : 672, "minY" : 355, "maxY" : 409, "prop" : { "x" : 634, "y" : 355, "width" : 38, "height" : 23 }, "textPosition" : { "x" : 640, "y" : 356 }, "connectors" : [ { "edgeId" : 1441, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 657, "y" : 384 }, "to" : { "x" : 668, "y" : 409 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 663, "y" : 389 }, "b" : { "x" : 657, "y" : 384 }, "c" : { "x" : 656, "y" : 392 }, "type" : "ARROW", "centre" : { "x" : 656, "y" : 392 } } } ] }, { "id" : 5137, "reactomeId" : 113595, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 827, "y" : 754 }, "minX" : 770, "maxX" : 846, "minY" : 743, "maxY" : 766, "prop" : { "x" : 808, "y" : 743, "width" : 38, "height" : 23 }, "textPosition" : { "x" : 814, "y" : 744 }, "connectors" : [ { "edgeId" : 3138, "type" : "INPUT", "segments" : [ { "from" : { "x" : 802, "y" : 757 }, "to" : { "x" : 770, "y" : 763 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 780, "y" : 754 }, "b" : { "x" : 792, "y" : 766 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 786, "y" : 760 } } } } ] }, { "id" : 5138, "reactomeId" : 9681293, "displayName" : "IL6R:IL6R inhibitors", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 892, "y" : 19 }, "minX" : 829, "maxX" : 961, "minY" : 0, "maxY" : 76, "prop" : { "x" : 829, "y" : 6, "width" : 126, "height" : 26 }, "textPosition" : { "x" : 830, "y" : 11 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 955, "y" : 6 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 955, "y" : 6 } } }, "connectors" : [ { "edgeId" : 2, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 891, "y" : 35 }, "to" : { "x" : 891, "y" : 76 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 887, "y" : 76 }, "b" : { "x" : 895, "y" : 76 }, "c" : { "x" : 891, "y" : 76 }, "type" : "STOP", "centre" : { "x" : 891, "y" : 76 } } } ] }, { "id" : 402, "reactomeId" : 9935413, "displayName" : "CBLL1:PolyUb-p-2Y-CDH1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 698, "y" : 2002 }, "minX" : 642, "maxX" : 760, "minY" : 1978, "maxY" : 2021, "prop" : { "x" : 642, "y" : 1984, "width" : 112, "height" : 37 }, "textPosition" : { "x" : 645, "y" : 1986 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 754, "y" : 1984 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 754, "y" : 1984 } } }, "connectors" : [ { "edgeId" : 401, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 404, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5139, "reactomeId" : 1067674, "displayName" : "IL6:IL6R-2:IL6ST-2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1033, "y" : 79 }, "minX" : 973, "maxX" : 1099, "minY" : 63, "maxY" : 169, "prop" : { "x" : 973, "y" : 69, "width" : 120, "height" : 21 }, "textPosition" : { "x" : 976, "y" : 69 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1093, "y" : 69 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1093, "y" : 69 } } }, "connectors" : [ { "edgeId" : 12, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1033, "y" : 93 }, "to" : { "x" : 1033, "y" : 169 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1029, "y" : 169 }, "b" : { "x" : 1037, "y" : 169 }, "c" : { "x" : 1033, "y" : 169 }, "type" : "STOP", "centre" : { "x" : 1033, "y" : 169 } } } ] }, { "id" : 20, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1655, "y" : 377 }, "minX" : 1638, "maxX" : 1685, "minY" : 293, "maxY" : 387, "prop" : { "x" : 1638, "y" : 367, "width" : 35, "height" : 20 }, "textPosition" : { "x" : 1640, "y" : 367 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1668, "y" : 372 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1668, "y" : 372 } } }, "connectors" : [ { "edgeId" : 19, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1658, "y" : 364 }, "to" : { "x" : 1685, "y" : 293 } } ], "stoichiometry" : { "value" : 12, "shape" : { "a" : { "x" : 1665, "y" : 322 }, "b" : { "x" : 1677, "y" : 334 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1671, "y" : 328 } } } } ] }, { "id" : 405, "reactomeId" : 9935550, "displayName" : "CBLL1:PolyUb-p-2Y-CDH1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 870, "y" : 1857 }, "minX" : 791, "maxX" : 956, "minY" : 1836, "maxY" : 1872, "prop" : { "x" : 791, "y" : 1842, "width" : 159, "height" : 30 }, "textPosition" : { "x" : 791, "y" : 1851 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 950, "y" : 1842 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 950, "y" : 1842 } } }, "connectors" : [ { "edgeId" : 404, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 407, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1751, "y" : 374 }, "minX" : 1729, "maxX" : 1771, "minY" : 295, "maxY" : 384, "prop" : { "x" : 1733, "y" : 365, "width" : 37, "height" : 19 }, "textPosition" : { "x" : 1735, "y" : 364 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1765, "y" : 370 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1765, "y" : 370 } } }, "connectors" : [ { "edgeId" : 19, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1748, "y" : 362 }, "to" : { "x" : 1729, "y" : 295 } } ], "stoichiometry" : { "value" : 12, "shape" : { "a" : { "x" : 1732, "y" : 322 }, "b" : { "x" : 1744, "y" : 334 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1738, "y" : 328 } } }, "endShape" : { "a" : { "x" : 1742, "y" : 356 }, "b" : { "x" : 1748, "y" : 362 }, "c" : { "x" : 1750, "y" : 354 }, "type" : "ARROW", "centre" : { "x" : 1750, "y" : 354 } } } ] }, { "id" : 22, "reactomeId" : 1112515, "displayName" : "IL6 receptor hexamer:Activated JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1808, "y" : 301 }, "minX" : 1729, "maxX" : 1896, "minY" : 271, "maxY" : 325, "prop" : { "x" : 1756, "y" : 277, "width" : 104, "height" : 48 }, "textPosition" : { "x" : 1760, "y" : 276 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1860, "y" : 277 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1860, "y" : 277 } } }, "connectors" : [ { "edgeId" : 19, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1753, "y" : 297 }, "to" : { "x" : 1729, "y" : 295 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1746, "y" : 300 }, "b" : { "x" : 1753, "y" : 297 }, "c" : { "x" : 1746, "y" : 292 }, "type" : "ARROW", "centre" : { "x" : 1746, "y" : 292 } } }, { "edgeId" : 38, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1863, "y" : 295 }, "to" : { "x" : 1896, "y" : 291 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5015, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 795, "y" : 925 }, "minX" : 717, "maxX" : 812, "minY" : 915, "maxY" : 1023, "prop" : { "x" : 779, "y" : 916, "width" : 32, "height" : 19 }, "textPosition" : { "x" : 782, "y" : 908 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 806, "y" : 921 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 806, "y" : 921 } } }, "connectors" : [ { "edgeId" : 4998, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 787, "y" : 938 }, "to" : { "x" : 717, "y" : 1023 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 786, "y" : 946 }, "b" : { "x" : 787, "y" : 938 }, "c" : { "x" : 780, "y" : 941 }, "type" : "ARROW", "centre" : { "x" : 780, "y" : 941 } } } ] }, { "id" : 408, "reactomeId" : 9935542, "displayName" : "(CTSB,CTSL,CTSS)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 939, "y" : 1779 }, "minX" : 716, "maxX" : 1000, "minY" : 1767, "maxY" : 1815, "prop" : { "x" : 878, "y" : 1767, "width" : 122, "height" : 25 }, "textPosition" : { "x" : 880, "y" : 1769 }, "connectors" : [ { "edgeId" : 407, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 872, "y" : 1787 }, "to" : { "x" : 724, "y" : 1810 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 720, "y" : 1811 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 720, "y" : 1811 } } } ] }, { "id" : 1184, "reactomeId" : 9959442, "displayName" : "RAC1:GDP,(CDC42:GDP)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 614, "y" : 1107 }, "minX" : 573, "maxX" : 714, "minY" : 1092, "maxY" : 1123, "prop" : { "x" : 573, "y" : 1092, "width" : 83, "height" : 31 }, "textPosition" : { "x" : 577, "y" : 1083 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 4998, "type" : "INPUT", "segments" : [ { "from" : { "x" : 662, "y" : 1105 }, "to" : { "x" : 714, "y" : 1104 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1442, "reactomeId" : 68819, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 671, "y" : 484 }, "minX" : 623, "maxX" : 718, "minY" : 411, "maxY" : 502, "prop" : { "x" : 630, "y" : 466, "width" : 82, "height" : 36 }, "textPosition" : { "x" : 633, "y" : 453 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 712, "y" : 466 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 712, "y" : 466 } } }, "connectors" : [ { "edgeId" : 1441, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 659, "y" : 463 }, "to" : { "x" : 629, "y" : 418 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 627, "y" : 415 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 627, "y" : 415 } } } ] }, { "id" : 5155, "reactomeId" : 6783589, "displayName" : "Interleukin-6 family signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1049, "y" : 469 }, "minX" : 963, "maxX" : 1136, "minY" : 433, "maxY" : 505, "prop" : { "x" : 963, "y" : 433, "width" : 173, "height" : 72 }, "textPosition" : { "x" : 981, "y" : 447 }, "connectors" : [ ] }, { "id" : 1188, "reactomeId" : 9959444, "displayName" : "Engaged CDH1,(CDH11)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 371, "y" : 599 }, "minX" : 272, "maxX" : 821, "minY" : 334, "maxY" : 697, "prop" : { "x" : 272, "y" : 588, "width" : 198, "height" : 23 }, "textPosition" : { "x" : 292, "y" : 589 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 3138, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 476, "y" : 610 }, "to" : { "x" : 566, "y" : 621 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 566, "y" : 625 }, "b" : { "x" : 566, "y" : 617 }, "c" : { "x" : 566, "y" : 621 }, "type" : "STOP", "centre" : { "x" : 566, "y" : 621 } } }, { "edgeId" : 4813, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 409, "y" : 617 }, "to" : { "x" : 698, "y" : 697 } }, { "from" : { "x" : 698, "y" : 697 }, "to" : { "x" : 776, "y" : 335 } }, { "from" : { "x" : 776, "y" : 335 }, "to" : { "x" : 821, "y" : 338 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 821, "y" : 342 }, "b" : { "x" : 821, "y" : 334 }, "c" : { "x" : 821, "y" : 338 }, "type" : "STOP", "centre" : { "x" : 821, "y" : 338 } } } ] }, { "id" : 39, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1879, "y" : 381 }, "minX" : 1861, "maxX" : 1898, "minY" : 291, "maxY" : 397, "prop" : { "x" : 1861, "y" : 366, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 1863, "y" : 371 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1892, "y" : 371 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1892, "y" : 371 } } }, "connectors" : [ { "edgeId" : 38, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1881, "y" : 363 }, "to" : { "x" : 1896, "y" : 291 } } ], "stoichiometry" : { "value" : 20, "shape" : { "a" : { "x" : 1882, "y" : 321 }, "b" : { "x" : 1894, "y" : 333 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1888, "y" : 327 } } } } ] }, { "id" : 40, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1972, "y" : 390 }, "minX" : 1950, "maxX" : 1991, "minY" : 292, "maxY" : 403, "prop" : { "x" : 1954, "y" : 377, "width" : 36, "height" : 26 }, "textPosition" : { "x" : 1955, "y" : 379 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1985, "y" : 382 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1985, "y" : 382 } } }, "connectors" : [ { "edgeId" : 38, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1969, "y" : 374 }, "to" : { "x" : 1950, "y" : 292 } } ], "stoichiometry" : { "value" : 20, "shape" : { "a" : { "x" : 1953, "y" : 327 }, "b" : { "x" : 1965, "y" : 339 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1959, "y" : 333 } } }, "endShape" : { "a" : { "x" : 1964, "y" : 368 }, "b" : { "x" : 1969, "y" : 374 }, "c" : { "x" : 1971, "y" : 366 }, "type" : "ARROW", "centre" : { "x" : 1971, "y" : 366 } } } ] }, { "id" : 41, "reactomeId" : 1112594, "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2052, "y" : 296 }, "minX" : 1863, "maxX" : 2120, "minY" : 257, "maxY" : 634, "prop" : { "x" : 1990, "y" : 263, "width" : 124, "height" : 66 }, "textPosition" : { "x" : 1988, "y" : 252 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2114, "y" : 263 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2114, "y" : 263 } } }, "connectors" : [ { "edgeId" : 135, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2057, "y" : 332 }, "to" : { "x" : 2067, "y" : 394 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1987, "y" : 293 }, "to" : { "x" : 1950, "y" : 292 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1980, "y" : 297 }, "b" : { "x" : 1987, "y" : 293 }, "c" : { "x" : 1980, "y" : 289 }, "type" : "ARROW", "centre" : { "x" : 1980, "y" : 289 } } }, { "edgeId" : 187, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2033, "y" : 332 }, "to" : { "x" : 1863, "y" : 634 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2033, "y" : 340 }, "b" : { "x" : 2033, "y" : 332 }, "c" : { "x" : 2026, "y" : 336 }, "type" : "ARROW", "centre" : { "x" : 2026, "y" : 336 } } } ] }, { "id" : 169, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2034, "y" : 645 }, "minX" : 2018, "maxX" : 2095, "minY" : 631, "maxY" : 658, "prop" : { "x" : 2018, "y" : 632, "width" : 33, "height" : 26 }, "textPosition" : { "x" : 2019, "y" : 634 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2046, "y" : 637 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2046, "y" : 637 } } }, "connectors" : [ { "edgeId" : 168, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2054, "y" : 645 }, "to" : { "x" : 2095, "y" : 645 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 170, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2023, "y" : 704 }, "minX" : 2007, "maxX" : 2089, "minY" : 689, "maxY" : 719, "prop" : { "x" : 2007, "y" : 690, "width" : 33, "height" : 29 }, "textPosition" : { "x" : 2007, "y" : 694 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2035, "y" : 695 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2035, "y" : 695 } } }, "connectors" : [ { "edgeId" : 168, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2043, "y" : 705 }, "to" : { "x" : 2089, "y" : 709 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2050, "y" : 702 }, "b" : { "x" : 2043, "y" : 705 }, "c" : { "x" : 2050, "y" : 710 }, "type" : "ARROW", "centre" : { "x" : 2050, "y" : 710 } } } ] }, { "id" : 171, "reactomeId" : 9958930, "displayName" : "Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:p-Y705-STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2076, "y" : 769 }, "minX" : 1981, "maxX" : 2177, "minY" : 709, "maxY" : 798, "prop" : { "x" : 1981, "y" : 740, "width" : 190, "height" : 58 }, "textPosition" : { "x" : 1982, "y" : 749 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2171, "y" : 740 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2171, "y" : 740 } } }, "connectors" : [ { "edgeId" : 168, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2082, "y" : 737 }, "to" : { "x" : 2089, "y" : 709 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2080, "y" : 729 }, "b" : { "x" : 2082, "y" : 737 }, "c" : { "x" : 2088, "y" : 731 }, "type" : "ARROW", "centre" : { "x" : 2088, "y" : 731 } } }, { "edgeId" : 187, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 811, "reactomeId" : 9959033, "displayName" : "NFKB(1-433):RELA:IL6 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1052, "y" : 601 }, "minX" : 911, "maxX" : 1117, "minY" : 556, "maxY" : 617, "prop" : { "x" : 993, "y" : 585, "width" : 118, "height" : 32 }, "textPosition" : { "x" : 1004, "y" : 582 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1111, "y" : 585 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1111, "y" : 585 } } }, "connectors" : [ { "edgeId" : 3155, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 3157, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 998, "y" : 582 }, "to" : { "x" : 911, "y" : 558 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 919, "y" : 556 }, "b" : { "x" : 911, "y" : 558 }, "c" : { "x" : 917, "y" : 564 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 917, "y" : 564 } } } ] }, { "id" : 1073, "reactomeId" : 9833686, "displayName" : "trans-CDH11:CTNDD1:CTNNB1/JUP:CTNNA1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 248, "y" : 801 }, "minX" : 172, "maxX" : 349, "minY" : 744, "maxY" : 823, "prop" : { "x" : 172, "y" : 780, "width" : 153, "height" : 43 }, "textPosition" : { "x" : 176, "y" : 784 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 1072, "type" : "INPUT", "segments" : [ { "from" : { "x" : 286, "y" : 774 }, "to" : { "x" : 349, "y" : 744 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1074, "reactomeId" : 9762141, "displayName" : "CDH11:CTNDD1:CTNNB1/JUP:CTNNA1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 463, "y" : 779 }, "minX" : 349, "maxX" : 538, "minY" : 744, "maxY" : 800, "prop" : { "x" : 389, "y" : 758, "width" : 149, "height" : 42 }, "textPosition" : { "x" : 396, "y" : 761 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 2732, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1072, "type" : "INPUT", "segments" : [ { "from" : { "x" : 394, "y" : 752 }, "to" : { "x" : 349, "y" : 744 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1076, "reactomeId" : 9833673, "displayName" : "Homotypic CDH11 trans dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 355, "y" : 669 }, "minX" : 284, "maxX" : 433, "minY" : 646, "maxY" : 686, "prop" : { "x" : 284, "y" : 652, "width" : 143, "height" : 34 }, "textPosition" : { "x" : 294, "y" : 651 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 427, "y" : 652 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 427, "y" : 652 } } }, "connectors" : [ { "edgeId" : 1072, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1077, "reactomeId" : 74112, "displayName" : "Ca2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 358, "y" : 820 }, "minX" : 338, "maxX" : 379, "minY" : 744, "maxY" : 833, "prop" : { "x" : 338, "y" : 808, "width" : 40, "height" : 25 }, "textPosition" : { "x" : 342, "y" : 803 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 373, "y" : 813 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 373, "y" : 813 } } }, "connectors" : [ { "edgeId" : 1072, "type" : "INPUT", "segments" : [ { "from" : { "x" : 356, "y" : 805 }, "to" : { "x" : 349, "y" : 744 } } ], "stoichiometry" : { "value" : 24, "shape" : { "a" : { "x" : 346, "y" : 768 }, "b" : { "x" : 358, "y" : 780 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 352, "y" : 774 } } } } ] }, { "id" : 5048, "reactomeId" : 9934368, "displayName" : "CTNNB1,JUP", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 693, "y" : 793 }, "minX" : 574, "maxX" : 756, "minY" : 782, "maxY" : 850, "prop" : { "x" : 630, "y" : 782, "width" : 126, "height" : 23 }, "textPosition" : { "x" : 652, "y" : 783 }, "connectors" : [ { "edgeId" : 2732, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 668, "y" : 811 }, "to" : { "x" : 574, "y" : 850 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 663, "y" : 817 }, "b" : { "x" : 668, "y" : 811 }, "c" : { "x" : 660, "y" : 810 }, "type" : "ARROW", "centre" : { "x" : 660, "y" : 810 } } } ] }, { "id" : 188, "reactomeId" : 914048, "displayName" : "p-Y705-STAT3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1746, "y" : 631 }, "minX" : 1660, "maxX" : 1863, "minY" : 612, "maxY" : 644, "prop" : { "x" : 1695, "y" : 618, "width" : 102, "height" : 26 }, "innerProp" : { "x" : 1695, "y" : 624, "width" : 102, "height" : 20 }, "textPosition" : { "x" : 1699, "y" : 620 }, "nodeAttachments" : [ { "reactomeId" : 539045, "label" : "P", "description" : "O4'-phospho-L-tyrosine at 705", "shape" : { "a" : { "x" : 1706, "y" : 612 }, "b" : { "x" : 1718, "y" : 624 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1712, "y" : 618 } } } ], "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1797, "y" : 618 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1797, "y" : 618 } } }, "connectors" : [ { "edgeId" : 1874, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1660, "y" : 624 }, "b" : { "x" : 1672, "y" : 636 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1666, "y" : 630 } } } }, { "edgeId" : 187, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1800, "y" : 632 }, "to" : { "x" : 1863, "y" : 634 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1807, "y" : 628 }, "b" : { "x" : 1800, "y" : 632 }, "c" : { "x" : 1807, "y" : 636 }, "type" : "ARROW", "centre" : { "x" : 1807, "y" : 636 } } } ] }, { "id" : 5308, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 711, "y" : 428 }, "minX" : 668, "maxX" : 732, "minY" : 409, "maxY" : 441, "prop" : { "x" : 691, "y" : 416, "width" : 40, "height" : 25 }, "textPosition" : { "x" : 695, "y" : 418 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 726, "y" : 421 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 726, "y" : 421 } } }, "connectors" : [ { "edgeId" : 1441, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 688, "y" : 419 }, "to" : { "x" : 668, "y" : 409 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 680, "y" : 419 }, "b" : { "x" : 688, "y" : 419 }, "c" : { "x" : 684, "y" : 412 }, "type" : "ARROW", "centre" : { "x" : 684, "y" : 412 } } } ] }, { "id" : 190, "reactomeId" : 1112526, "displayName" : "p-Y705-STAT3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1584, "y" : 773 }, "minX" : 1518, "maxX" : 1656, "minY" : 755, "maxY" : 785, "prop" : { "x" : 1518, "y" : 761, "width" : 132, "height" : 24 }, "textPosition" : { "x" : 1518, "y" : 764 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1650, "y" : 761 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1650, "y" : 761 } } }, "connectors" : [ { "edgeId" : 1874, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1875, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 192, "reactomeId" : 1112525, "displayName" : "p-Y705-STAT3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1048, "y" : 766 }, "minX" : 983, "maxX" : 1120, "minY" : 748, "maxY" : 778, "prop" : { "x" : 983, "y" : 754, "width" : 131, "height" : 24 }, "textPosition" : { "x" : 1000, "y" : 743 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1114, "y" : 754 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1114, "y" : 754 } } }, "connectors" : [ { "edgeId" : 1875, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 3156, "reactomeId" : 3788729, "displayName" : "IL6 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 945, "y" : 656 }, "minX" : 913, "maxX" : 1040, "minY" : 628, "maxY" : 682, "prop" : { "x" : 913, "y" : 630, "width" : 64, "height" : 52 }, "textPosition" : { "x" : 914, "y" : 657 }, "connectors" : [ { "edgeId" : 3155, "type" : "INPUT", "segments" : [ { "from" : { "x" : 986, "y" : 632 }, "to" : { "x" : 1040, "y" : 671 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 3157, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 984, "y" : 628 }, "b" : { "x" : 977, "y" : 632 }, "c" : { "x" : 984, "y" : 636 }, "type" : "ARROW", "centre" : { "x" : 984, "y" : 636 } } }, { "id" : 342, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 480, "y" : 1555 }, "minX" : 397, "maxX" : 502, "minY" : 1540, "maxY" : 1569, "prop" : { "x" : 459, "y" : 1541, "width" : 42, "height" : 28 }, "textPosition" : { "x" : 464, "y" : 1544 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 496, "y" : 1546 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 496, "y" : 1546 } } }, "connectors" : [ { "edgeId" : 341, "type" : "INPUT", "segments" : [ { "from" : { "x" : 456, "y" : 1557 }, "to" : { "x" : 397, "y" : 1565 } } ], "stoichiometry" : { "value" : 10, "shape" : { "a" : { "x" : 420, "y" : 1555 }, "b" : { "x" : 432, "y" : 1567 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 426, "y" : 1561 } } } } ] }, { "id" : 343, "reactomeId" : 9934398, "displayName" : "Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 439, "y" : 1495 }, "minX" : 352, "maxX" : 526, "minY" : 1428, "maxY" : 1565, "prop" : { "x" : 352, "y" : 1466, "width" : 174, "height" : 58 }, "textPosition" : { "x" : 355, "y" : 1470 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 341, "type" : "INPUT", "segments" : [ { "from" : { "x" : 421, "y" : 1530 }, "to" : { "x" : 397, "y" : 1565 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1000, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 497, "y" : 1428 }, "b" : { "x" : 509, "y" : 1440 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 503, "y" : 1434 } } } } ] }, { "id" : 344, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 629, "y" : 1693 }, "minX" : 397, "maxX" : 650, "minY" : 1646, "maxY" : 1707, "prop" : { "x" : 610, "y" : 1680, "width" : 39, "height" : 27 }, "textPosition" : { "x" : 613, "y" : 1683 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 644, "y" : 1685 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 644, "y" : 1685 } } }, "connectors" : [ { "edgeId" : 341, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 607, "y" : 1689 }, "to" : { "x" : 397, "y" : 1646 } } ], "stoichiometry" : { "value" : 10, "shape" : { "a" : { "x" : 496, "y" : 1661 }, "b" : { "x" : 508, "y" : 1673 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 502, "y" : 1667 } } }, "endShape" : { "a" : { "x" : 599, "y" : 1692 }, "b" : { "x" : 607, "y" : 1689 }, "c" : { "x" : 601, "y" : 1684 }, "type" : "ARROW", "centre" : { "x" : 601, "y" : 1684 } } } ] }, { "id" : 345, "reactomeId" : 191697, "displayName" : "CTNNA1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 656, "y" : 1651 }, "minX" : 397, "maxX" : 693, "minY" : 1634, "maxY" : 1663, "prop" : { "x" : 626, "y" : 1640, "width" : 61, "height" : 23 }, "textPosition" : { "x" : 628, "y" : 1641 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 687, "y" : 1640 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 687, "y" : 1640 } } }, "connectors" : [ { "edgeId" : 341, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 623, "y" : 1650 }, "to" : { "x" : 397, "y" : 1646 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 504, "y" : 1642 }, "b" : { "x" : 516, "y" : 1654 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 510, "y" : 1648 } } }, "endShape" : { "a" : { "x" : 616, "y" : 1654 }, "b" : { "x" : 623, "y" : 1650 }, "c" : { "x" : 616, "y" : 1646 }, "type" : "ARROW", "centre" : { "x" : 616, "y" : 1646 } } } ] }, { "id" : 346, "reactomeId" : 9934825, "displayName" : "Man,Man9GlucNAc2,p-3S,2Y-CDH1:p-Y-CTNND1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 410, "y" : 1744 }, "minX" : 328, "maxX" : 492, "minY" : 1646, "maxY" : 1793, "prop" : { "x" : 328, "y" : 1723, "width" : 164, "height" : 43 }, "textPosition" : { "x" : 331, "y" : 1727 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 341, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 407, "y" : 1717 }, "to" : { "x" : 397, "y" : 1646 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 402, "y" : 1711 }, "b" : { "x" : 407, "y" : 1717 }, "c" : { "x" : 410, "y" : 1710 }, "type" : "ARROW", "centre" : { "x" : 410, "y" : 1710 } } }, { "edgeId" : 379, "type" : "INPUT", "segments" : [ { "from" : { "x" : 407, "y" : 1772 }, "to" : { "x" : 404, "y" : 1793 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 347, "reactomeId" : 9935537, "displayName" : "p-Y-CTNNB1,p-Y-JUP", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 660, "y" : 1588 }, "minX" : 397, "maxX" : 706, "minY" : 1564, "maxY" : 1646, "prop" : { "x" : 614, "y" : 1564, "width" : 92, "height" : 48 }, "textPosition" : { "x" : 618, "y" : 1570 }, "connectors" : [ { "edgeId" : 341, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 608, "y" : 1598 }, "to" : { "x" : 397, "y" : 1646 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 602, "y" : 1603 }, "b" : { "x" : 608, "y" : 1598 }, "c" : { "x" : 600, "y" : 1596 }, "type" : "ARROW", "centre" : { "x" : 600, "y" : 1596 } } } ] }, { "id" : 348, "reactomeId" : 1810408, "displayName" : "MyrG-p-Y419-SRC", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 418, "y" : 1417 }, "minX" : 326, "maxX" : 653, "minY" : 856, "maxY" : 1607, "prop" : { "x" : 367, "y" : 1397, "width" : 103, "height" : 40 }, "innerProp" : { "x" : 367, "y" : 1403, "width" : 103, "height" : 34 }, "textPosition" : { "x" : 374, "y" : 1399 }, "nodeAttachments" : [ { "reactomeId" : 1810396, "label" : "My", "description" : "N-myristoylglycine at 2", "shape" : { "a" : { "x" : 384, "y" : 1391 }, "b" : { "x" : 396, "y" : 1403 }, "s" : "My", "type" : "BOX", "empty" : true, "centre" : { "x" : 390, "y" : 1397 } } }, { "reactomeId" : 1810398, "label" : "P", "description" : "O4'-phospho-L-tyrosine at 419", "shape" : { "a" : { "x" : 396, "y" : 1391 }, "b" : { "x" : 408, "y" : 1403 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 402, "y" : 1397 } } } ], "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 470, "y" : 1397 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 470, "y" : 1397 } } }, "connectors" : [ { "edgeId" : 3083, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 473, "y" : 1419 }, "to" : { "x" : 645, "y" : 1427 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 649, "y" : 1427 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 649, "y" : 1427 } } }, { "edgeId" : 341, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 369, "y" : 1440 }, "to" : { "x" : 326, "y" : 1455 } }, { "from" : { "x" : 326, "y" : 1455 }, "to" : { "x" : 326, "y" : 1603 } }, { "from" : { "x" : 326, "y" : 1603 }, "to" : { "x" : 384, "y" : 1603 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 388, "y" : 1603 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 388, "y" : 1603 } } }, { "edgeId" : 2732, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 447, "y" : 1394 }, "to" : { "x" : 525, "y" : 1345 } }, { "from" : { "x" : 525, "y" : 1345 }, "to" : { "x" : 498, "y" : 856 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 502, "y" : 863 }, "b" : { "x" : 498, "y" : 856 }, "c" : { "x" : 494, "y" : 863 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 494, "y" : 863 } } } ] }, { "id" : 3296, "reactomeId" : 1067656, "displayName" : "JAK1, JAK2, (TYK2)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 898, "y" : 403 }, "minX" : 875, "maxX" : 922, "minY" : 337, "maxY" : 423, "prop" : { "x" : 875, "y" : 383, "width" : 47, "height" : 40 }, "textPosition" : { "x" : 875, "y" : 379 }, "connectors" : [ { "edgeId" : 3295, "type" : "INPUT", "segments" : [ { "from" : { "x" : 892, "y" : 377 }, "to" : { "x" : 881, "y" : 337 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 3297, "reactomeId" : 448453, "displayName" : "IL6ST", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 856, "y" : 293 }, "minX" : 835, "maxX" : 883, "minY" : 275, "maxY" : 337, "prop" : { "x" : 835, "y" : 281, "width" : 42, "height" : 25 }, "textPosition" : { "x" : 836, "y" : 283 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 877, "y" : 281 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 877, "y" : 281 } } }, "connectors" : [ { "edgeId" : 4813, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 3295, "type" : "INPUT", "segments" : [ { "from" : { "x" : 863, "y" : 309 }, "to" : { "x" : 881, "y" : 337 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 996, "reactomeId" : 74112, "displayName" : "Ca2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 343, "y" : 1073 }, "minX" : 323, "maxX" : 364, "minY" : 967, "maxY" : 1089, "prop" : { "x" : 323, "y" : 1058, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 327, "y" : 1056 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 358, "y" : 1063 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 358, "y" : 1063 } } }, "connectors" : [ { "edgeId" : 995, "type" : "INPUT", "segments" : [ { "from" : { "x" : 341, "y" : 1055 }, "to" : { "x" : 333, "y" : 967 } } ], "stoichiometry" : { "value" : 120, "shape" : { "a" : { "x" : 330, "y" : 1004 }, "b" : { "x" : 345, "y" : 1019 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 337, "y" : 1011 } } } } ] }, { "id" : 997, "reactomeId" : 9934440, "displayName" : "trans-homotypic CDH1 cluster:F-actin:VCL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 243, "y" : 1019 }, "minX" : 168, "maxX" : 333, "minY" : 967, "maxY" : 1038, "prop" : { "x" : 168, "y" : 1000, "width" : 150, "height" : 38 }, "textPosition" : { "x" : 168, "y" : 1003 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 318, "y" : 1000 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 318, "y" : 1000 } } }, "connectors" : [ { "edgeId" : 995, "type" : "INPUT", "segments" : [ { "from" : { "x" : 275, "y" : 997 }, "to" : { "x" : 333, "y" : 967 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 998, "reactomeId" : 9934501, "displayName" : "Homotypic CDH1 cis-cluster:F-actin:VCL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 427, "y" : 1004 }, "minX" : 333, "maxX" : 507, "minY" : 967, "maxY" : 1024, "prop" : { "x" : 354, "y" : 984, "width" : 147, "height" : 40 }, "textPosition" : { "x" : 359, "y" : 989 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 501, "y" : 984 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 501, "y" : 984 } } }, "connectors" : [ { "edgeId" : 995, "type" : "INPUT", "segments" : [ { "from" : { "x" : 376, "y" : 981 }, "to" : { "x" : 333, "y" : 967 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1005, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 999, "reactomeId" : 9934435, "displayName" : "Homotypic CDH1 trans-dimer cluster", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 343, "y" : 872 }, "minX" : 270, "maxX" : 422, "minY" : 847, "maxY" : 891, "prop" : { "x" : 270, "y" : 853, "width" : 146, "height" : 38 }, "textPosition" : { "x" : 279, "y" : 856 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 416, "y" : 853 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 416, "y" : 853 } } }, "connectors" : [ { "edgeId" : 995, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1001, "reactomeId" : 9934413, "displayName" : "Homotypic CDH1 cis-cluster", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 397, "y" : 1339 }, "minX" : 338, "maxX" : 462, "minY" : 1266, "maxY" : 1356, "prop" : { "x" : 338, "y" : 1323, "width" : 118, "height" : 33 }, "textPosition" : { "x" : 339, "y" : 1321 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 456, "y" : 1323 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 456, "y" : 1323 } } }, "connectors" : [ { "edgeId" : 1000, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1002, "type" : "INPUT", "segments" : [ { "from" : { "x" : 404, "y" : 1320 }, "to" : { "x" : 430, "y" : 1266 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1003, "reactomeId" : 9913263, "displayName" : "F-actin (all)", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 668, "y" : 1271 }, "minX" : 430, "maxX" : 699, "minY" : 1256, "maxY" : 1287, "prop" : { "x" : 637, "y" : 1256, "width" : 62, "height" : 31 }, "textPosition" : { "x" : 641, "y" : 1254 }, "connectors" : [ { "edgeId" : 1002, "type" : "INPUT", "segments" : [ { "from" : { "x" : 634, "y" : 1270 }, "to" : { "x" : 430, "y" : 1266 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 526, "y" : 1262 }, "b" : { "x" : 538, "y" : 1274 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 532, "y" : 1268 } } } } ] }, { "id" : 1004, "reactomeId" : 9934481, "displayName" : "Homotypic CDH1 cis-cluster:F-actin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 400, "y" : 1177 }, "minX" : 339, "maxX" : 467, "minY" : 1110, "maxY" : 1196, "prop" : { "x" : 339, "y" : 1158, "width" : 122, "height" : 38 }, "textPosition" : { "x" : 341, "y" : 1161 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 461, "y" : 1158 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 461, "y" : 1158 } } }, "connectors" : [ { "edgeId" : 1002, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1005, "type" : "INPUT", "segments" : [ { "from" : { "x" : 409, "y" : 1155 }, "to" : { "x" : 434, "y" : 1110 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1006, "reactomeId" : 350753, "displayName" : "VCL", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 648, "y" : 1182 }, "minX" : 434, "maxX" : 671, "minY" : 1110, "maxY" : 1191, "prop" : { "x" : 631, "y" : 1173, "width" : 34, "height" : 18 }, "textPosition" : { "x" : 633, "y" : 1172 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 665, "y" : 1173 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 665, "y" : 1173 } } }, "connectors" : [ { "edgeId" : 1005, "type" : "INPUT", "segments" : [ { "from" : { "x" : 628, "y" : 1176 }, "to" : { "x" : 434, "y" : 1110 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 525, "y" : 1137 }, "b" : { "x" : 537, "y" : 1149 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 531, "y" : 1143 } } } } ] }, { "id" : 757, "reactomeId" : 194043, "displayName" : "NFKB1(1-433):RELA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 790, "y" : 702 }, "minX" : 727, "maxX" : 860, "minY" : 683, "maxY" : 716, "prop" : { "x" : 727, "y" : 689, "width" : 127, "height" : 27 }, "textPosition" : { "x" : 727, "y" : 695 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 854, "y" : 689 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 854, "y" : 689 } } }, "connectors" : [ { "edgeId" : 756, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 758, "reactomeId" : 194047, "displayName" : "NFKB1(1-433):RELA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1026, "y" : 709 }, "minX" : 962, "maxX" : 1096, "minY" : 671, "maxY" : 722, "prop" : { "x" : 962, "y" : 697, "width" : 128, "height" : 25 }, "textPosition" : { "x" : 962, "y" : 701 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1090, "y" : 697 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1090, "y" : 697 } } }, "connectors" : [ { "edgeId" : 3155, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1030, "y" : 694 }, "to" : { "x" : 1040, "y" : 671 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 756, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 759, "reactomeId" : 9959034, "displayName" : "RAC1:GTP,(CDC42:GTP)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 602, "y" : 948 }, "minX" : 557, "maxX" : 900, "minY" : 718, "maxY" : 1023, "prop" : { "x" : 557, "y" : 933, "width" : 90, "height" : 31 }, "textPosition" : { "x" : 558, "y" : 931 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 3138, "type" : "INPUT", "segments" : [ { "from" : { "x" : 632, "y" : 927 }, "to" : { "x" : 769, "y" : 863 } }, { "from" : { "x" : 769, "y" : 863 }, "to" : { "x" : 770, "y" : 763 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 4998, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 625, "y" : 970 }, "to" : { "x" : 717, "y" : 1023 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 633, "y" : 970 }, "b" : { "x" : 625, "y" : 970 }, "c" : { "x" : 629, "y" : 977 }, "type" : "ARROW", "centre" : { "x" : 629, "y" : 977 } } }, { "edgeId" : 756, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 653, "y" : 935 }, "to" : { "x" : 802, "y" : 893 } }, { "from" : { "x" : 802, "y" : 893 }, "to" : { "x" : 900, "y" : 718 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 900, "y" : 726 }, "b" : { "x" : 900, "y" : 718 }, "c" : { "x" : 893, "y" : 722 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 893, "y" : 722 } } } ] }, { "id" : 380, "reactomeId" : 8876991, "displayName" : "CBLL1 dimer:Zn2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 549, "y" : 1814 }, "minX" : 404, "maxX" : 612, "minY" : 1793, "maxY" : 1827, "prop" : { "x" : 492, "y" : 1801, "width" : 114, "height" : 26 }, "textPosition" : { "x" : 505, "y" : 1792 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 606, "y" : 1801 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 606, "y" : 1801 } } }, "connectors" : [ { "edgeId" : 407, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 379, "type" : "INPUT", "segments" : [ { "from" : { "x" : 489, "y" : 1805 }, "to" : { "x" : 404, "y" : 1793 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 440, "y" : 1793 }, "b" : { "x" : 452, "y" : 1805 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 446, "y" : 1799 } } } } ] }, { "id" : 381, "reactomeId" : 418996, "displayName" : "CTNND1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 511, "y" : 1867 }, "minX" : 395, "maxX" : 546, "minY" : 1850, "maxY" : 1879, "prop" : { "x" : 482, "y" : 1856, "width" : 58, "height" : 23 }, "textPosition" : { "x" : 482, "y" : 1857 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 540, "y" : 1856 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 540, "y" : 1856 } } }, "connectors" : [ { "edgeId" : 379, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 479, "y" : 1866 }, "to" : { "x" : 395, "y" : 1863 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 431, "y" : 1858 }, "b" : { "x" : 443, "y" : 1870 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 437, "y" : 1864 } } }, "endShape" : { "a" : { "x" : 472, "y" : 1870 }, "b" : { "x" : 479, "y" : 1866 }, "c" : { "x" : 472, "y" : 1862 }, "type" : "ARROW", "centre" : { "x" : 472, "y" : 1862 } } } ] }, { "id" : 1022, "reactomeId" : 9764265, "displayName" : "Regulation of CDH1 Expression and Function", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 706, "y" : 1506 }, "minX" : 619, "maxX" : 794, "minY" : 1477, "maxY" : 1536, "prop" : { "x" : 619, "y" : 1477, "width" : 175, "height" : 59 }, "textPosition" : { "x" : 621, "y" : 1485 }, "connectors" : [ ] }, { "id" : 382, "reactomeId" : 9935231, "displayName" : "CBLL1:p-2Y-CDH1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 396, "y" : 1943 }, "minX" : 338, "maxX" : 460, "minY" : 1863, "maxY" : 2019, "prop" : { "x" : 338, "y" : 1934, "width" : 116, "height" : 19 }, "textPosition" : { "x" : 339, "y" : 1932 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 454, "y" : 1934 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 454, "y" : 1934 } } }, "connectors" : [ { "edgeId" : 398, "type" : "INPUT", "segments" : [ { "from" : { "x" : 398, "y" : 1956 }, "to" : { "x" : 408, "y" : 1988 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 398, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 388, "y" : 1956 }, "to" : { "x" : 353, "y" : 1995 } }, { "from" : { "x" : 353, "y" : 1995 }, "to" : { "x" : 397, "y" : 2014 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 401, "y" : 2015 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 401, "y" : 2015 } } }, { "edgeId" : 379, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 395, "y" : 1931 }, "to" : { "x" : 395, "y" : 1863 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 389, "y" : 1891 }, "b" : { "x" : 401, "y" : 1903 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 395, "y" : 1897 } } }, "endShape" : { "a" : { "x" : 391, "y" : 1924 }, "b" : { "x" : 395, "y" : 1931 }, "c" : { "x" : 399, "y" : 1924 }, "type" : "ARROW", "centre" : { "x" : 399, "y" : 1924 } } } ] } ], "edges" : [ { "id" : 2, "reactomeId" : 1067667, "displayName" : "IL6 binds IL6R", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 891, "y" : 85 }, "minX" : 776, "maxX" : 896, "minY" : 80, "maxY" : 251, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 776, "y" : 80 }, "to" : { "x" : 891, "y" : 85 } }, { "from" : { "x" : 891, "y" : 85 }, "to" : { "x" : 871, "y" : 251 } } ], "endShape" : { "a" : { "x" : 868, "y" : 244 }, "b" : { "x" : 871, "y" : 251 }, "c" : { "x" : 876, "y" : 245 }, "type" : "ARROW", "centre" : { "x" : 876, "y" : 245 } }, "reactionShape" : { "c" : { "x" : 891, "y" : 85 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 891, "y" : 85 } }, "inputs" : [ { "id" : 3, "points" : [ { "x" : 775, "y" : 258 } ] }, { "id" : 4, "points" : [ { "x" : 667, "y" : 210 }, { "x" : 641, "y" : 119 } ] } ], "outputs" : [ { "id" : 5 } ], "inhibitors" : [ { "id" : 5138, "points" : [ { "x" : 891, "y" : 35 } ] } ] }, { "id" : 3138, "reactomeId" : 9958873, "displayName" : "Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 575, "y" : 622 }, "minX" : 556, "maxX" : 770, "minY" : 498, "maxY" : 763, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 770, "y" : 763 }, "to" : { "x" : 577, "y" : 755 } }, { "from" : { "x" : 577, "y" : 755 }, "to" : { "x" : 575, "y" : 622 } }, { "from" : { "x" : 575, "y" : 622 }, "to" : { "x" : 556, "y" : 498 } } ], "endShape" : { "a" : { "x" : 561, "y" : 504 }, "b" : { "x" : 556, "y" : 498 }, "c" : { "x" : 553, "y" : 505 }, "type" : "ARROW", "centre" : { "x" : 553, "y" : 505 } }, "reactionShape" : { "a" : { "x" : 569, "y" : 616 }, "b" : { "x" : 581, "y" : 628 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 575, "y" : 622 } }, "inputs" : [ { "id" : 759, "points" : [ { "x" : 632, "y" : 927 }, { "x" : 769, "y" : 863 } ] }, { "id" : 5137, "points" : [ { "x" : 802, "y" : 757 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 1422 } ], "catalysts" : [ { "id" : 1423, "points" : [ { "x" : 620, "y" : 612 } ] } ], "inhibitors" : [ { "id" : 1188, "points" : [ { "x" : 476, "y" : 610 } ] } ] }, { "id" : 6, "reactomeId" : 1067640, "displayName" : "IL6 binds IL6R-2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 763, "y" : 203 }, "minX" : 731, "maxX" : 807, "minY" : 180, "maxY" : 210, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 731, "y" : 210 }, "to" : { "x" : 763, "y" : 203 } }, { "from" : { "x" : 763, "y" : 203 }, "to" : { "x" : 807, "y" : 180 } } ], "endShape" : { "a" : { "x" : 803, "y" : 187 }, "b" : { "x" : 807, "y" : 180 }, "c" : { "x" : 799, "y" : 180 }, "type" : "ARROW", "centre" : { "x" : 799, "y" : 180 } }, "reactionShape" : { "c" : { "x" : 763, "y" : 203 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 763, "y" : 203 } }, "inputs" : [ { "id" : 7, "points" : [ { "x" : 707, "y" : 178 } ] }, { "id" : 4, "points" : [ { "x" : 697, "y" : 217 } ] } ], "outputs" : [ { "id" : 8 } ] }, { "id" : 4998, "reactomeId" : 9970163, "displayName" : "SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42)", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 717, "y" : 1045 }, "minX" : 711, "maxX" : 723, "minY" : 1023, "maxY" : 1104, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 714, "y" : 1104 }, "to" : { "x" : 717, "y" : 1045 } }, { "from" : { "x" : 717, "y" : 1045 }, "to" : { "x" : 717, "y" : 1023 } } ], "reactionShape" : { "a" : { "x" : 711, "y" : 1039 }, "b" : { "x" : 723, "y" : 1051 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 717, "y" : 1045 } }, "inputs" : [ { "id" : 4999, "points" : [ { "x" : 676, "y" : 1070 } ] }, { "id" : 1184, "points" : [ { "x" : 662, "y" : 1105 } ] } ], "outputs" : [ { "id" : 759, "points" : [ { "x" : 625, "y" : 970 } ] }, { "id" : 5015, "points" : [ { "x" : 787, "y" : 938 } ] } ], "catalysts" : [ { "id" : 3085, "points" : [ { "x" : 736, "y" : 1156 } ] } ] }, { "id" : 135, "reactomeId" : 9958878, "displayName" : "Tyrosine phosphorylated IL6ST binds STAT3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2062, "y" : 451 }, "minX" : 2057, "maxX" : 2069, "minY" : 394, "maxY" : 537, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2067, "y" : 394 }, "to" : { "x" : 2062, "y" : 451 } }, { "from" : { "x" : 2062, "y" : 451 }, "to" : { "x" : 2069, "y" : 537 } } ], "endShape" : { "a" : { "x" : 2064, "y" : 530 }, "b" : { "x" : 2069, "y" : 537 }, "c" : { "x" : 2072, "y" : 530 }, "type" : "ARROW", "centre" : { "x" : 2072, "y" : 530 } }, "reactionShape" : { "c" : { "x" : 2062, "y" : 451 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2062, "y" : 451 } }, "inputs" : [ { "id" : 136, "points" : [ { "x" : 2034, "y" : 412 } ] }, { "id" : 41, "points" : [ { "x" : 2057, "y" : 332 } ] } ], "outputs" : [ { "id" : 137 } ] }, { "id" : 9, "reactomeId" : 1067688, "displayName" : "IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1040, "y" : 228 }, "minX" : 1000, "maxX" : 1084, "minY" : 213, "maxY" : 288, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1000, "y" : 213 }, "to" : { "x" : 1040, "y" : 228 } }, { "from" : { "x" : 1040, "y" : 228 }, "to" : { "x" : 1084, "y" : 288 } } ], "endShape" : { "a" : { "x" : 1077, "y" : 285 }, "b" : { "x" : 1084, "y" : 288 }, "c" : { "x" : 1083, "y" : 280 }, "type" : "ARROW", "centre" : { "x" : 1083, "y" : 280 } }, "reactionShape" : { "c" : { "x" : 1040, "y" : 228 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1040, "y" : 228 } }, "inputs" : [ { "id" : 5, "points" : [ { "x" : 897, "y" : 251 } ] }, { "id" : 10, "points" : [ { "x" : 995, "y" : 253 } ] } ], "outputs" : [ { "id" : 11 } ] }, { "id" : 3083, "reactomeId" : 9958892, "displayName" : "SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 661, "y" : 1428 }, "minX" : 655, "maxX" : 744, "minY" : 1302, "maxY" : 1434, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 656, "y" : 1427 }, "to" : { "x" : 661, "y" : 1428 } }, { "from" : { "x" : 661, "y" : 1428 }, "to" : { "x" : 744, "y" : 1302 } } ], "reactionShape" : { "a" : { "x" : 655, "y" : 1422 }, "b" : { "x" : 667, "y" : 1434 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 661, "y" : 1428 } }, "inputs" : [ { "id" : 3084, "points" : [ { "x" : 742, "y" : 1427 } ] }, { "id" : 3086, "points" : [ { "x" : 671, "y" : 1346 } ] } ], "outputs" : [ { "id" : 3087, "points" : [ { "x" : 798, "y" : 1269 } ] }, { "id" : 3085, "points" : [ { "x" : 741, "y" : 1227 } ] } ], "catalysts" : [ { "id" : 348, "points" : [ { "x" : 473, "y" : 1419 } ] } ] }, { "id" : 12, "reactomeId" : 1067651, "displayName" : "IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1033, "y" : 178 }, "minX" : 943, "maxX" : 1167, "minY" : 173, "maxY" : 286, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 943, "y" : 204 }, "to" : { "x" : 1033, "y" : 178 } }, { "from" : { "x" : 1033, "y" : 178 }, "to" : { "x" : 1167, "y" : 286 } } ], "endShape" : { "a" : { "x" : 1159, "y" : 285 }, "b" : { "x" : 1167, "y" : 286 }, "c" : { "x" : 1164, "y" : 279 }, "type" : "ARROW", "centre" : { "x" : 1164, "y" : 279 } }, "reactionShape" : { "c" : { "x" : 1033, "y" : 178 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1033, "y" : 178 } }, "inputs" : [ { "id" : 8, "points" : [ { "x" : 859, "y" : 180 } ] }, { "id" : 10, "points" : [ { "x" : 973, "y" : 253 } ] } ], "outputs" : [ { "id" : 13 } ], "inhibitors" : [ { "id" : 5139, "points" : [ { "x" : 1033, "y" : 93 } ] } ] }, { "id" : 4813, "reactomeId" : 9968598, "displayName" : "CDH1,CDH11 promote stabilization of IL6ST protein", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 830, "y" : 339 }, "minX" : 824, "maxX" : 869, "minY" : 309, "maxY" : 458, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 848, "y" : 309 }, "to" : { "x" : 830, "y" : 339 } }, { "from" : { "x" : 830, "y" : 339 }, "to" : { "x" : 869, "y" : 458 } } ], "reactionShape" : { "a" : { "x" : 824, "y" : 333 }, "b" : { "x" : 836, "y" : 345 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 830, "y" : 339 } }, "inputs" : [ { "id" : 3297 } ], "inhibitors" : [ { "id" : 1188, "points" : [ { "x" : 409, "y" : 617 }, { "x" : 698, "y" : 697 }, { "x" : 776, "y" : 335 } ] } ] }, { "id" : 14, "reactomeId" : 1067659, "displayName" : "Assembly of hexameric IL-6 receptor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1491, "y" : 298 }, "minX" : 1426, "maxX" : 1552, "minY" : 293, "maxY" : 303, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1426, "y" : 295 }, "to" : { "x" : 1491, "y" : 298 } }, { "from" : { "x" : 1491, "y" : 298 }, "to" : { "x" : 1552, "y" : 299 } } ], "endShape" : { "a" : { "x" : 1545, "y" : 303 }, "b" : { "x" : 1552, "y" : 299 }, "c" : { "x" : 1545, "y" : 295 }, "type" : "ARROW", "centre" : { "x" : 1545, "y" : 295 } }, "reactionShape" : { "c" : { "x" : 1491, "y" : 298 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1491, "y" : 298 } }, "inputs" : [ { "id" : 15, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 16 } ] }, { "id" : 398, "reactomeId" : 9934753, "displayName" : "CBLL1 ubiquitinates CDH1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 412, "y" : 2020 }, "minX" : 406, "maxX" : 418, "minY" : 1988, "maxY" : 2063, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 408, "y" : 1988 }, "to" : { "x" : 412, "y" : 2020 } }, { "from" : { "x" : 412, "y" : 2020 }, "to" : { "x" : 416, "y" : 2063 } } ], "endShape" : { "a" : { "x" : 411, "y" : 2056 }, "b" : { "x" : 416, "y" : 2063 }, "c" : { "x" : 419, "y" : 2056 }, "type" : "ARROW", "centre" : { "x" : 419, "y" : 2056 } }, "reactionShape" : { "a" : { "x" : 406, "y" : 2014 }, "b" : { "x" : 418, "y" : 2026 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 412, "y" : 2020 } }, "inputs" : [ { "id" : 399, "points" : [ { "x" : 612, "y" : 1927 } ], "stoichiometry" : 6 }, { "id" : 382, "points" : [ { "x" : 398, "y" : 1956 } ] } ], "outputs" : [ { "id" : 400 } ], "catalysts" : [ { "id" : 382, "points" : [ { "x" : 388, "y" : 1956 }, { "x" : 353, "y" : 1995 } ] } ] }, { "id" : 401, "reactomeId" : 9934752, "displayName" : "Ubiquitinated CDH1 is endocytosed", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 591, "y" : 2074 }, "minX" : 500, "maxX" : 670, "minY" : 2024, "maxY" : 2080, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 500, "y" : 2076 }, "to" : { "x" : 591, "y" : 2074 } }, { "from" : { "x" : 591, "y" : 2074 }, "to" : { "x" : 670, "y" : 2024 } } ], "endShape" : { "a" : { "x" : 666, "y" : 2031 }, "b" : { "x" : 670, "y" : 2024 }, "c" : { "x" : 662, "y" : 2024 }, "type" : "ARROW", "centre" : { "x" : 662, "y" : 2024 } }, "reactionShape" : { "a" : { "x" : 585, "y" : 2068 }, "b" : { "x" : 597, "y" : 2080 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 591, "y" : 2074 } }, "inputs" : [ { "id" : 400 } ], "outputs" : [ { "id" : 402 } ] }, { "id" : 1874, "reactomeId" : 2730595, "displayName" : "Phosphorylated STAT3 Forms Dimers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1640, "y" : 630 }, "minX" : 1588, "maxX" : 1692, "minY" : 625, "maxY" : 758, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1692, "y" : 630 }, "to" : { "x" : 1640, "y" : 630 } }, { "from" : { "x" : 1640, "y" : 630 }, "to" : { "x" : 1588, "y" : 758 } } ], "endShape" : { "a" : { "x" : 1587, "y" : 750 }, "b" : { "x" : 1588, "y" : 758 }, "c" : { "x" : 1594, "y" : 753 }, "type" : "ARROW", "centre" : { "x" : 1594, "y" : 753 } }, "reactionShape" : { "c" : { "x" : 1640, "y" : 630 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1640, "y" : 630 } }, "inputs" : [ { "id" : 188, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 190 } ] }, { "id" : 3155, "reactomeId" : 9958869, "displayName" : "Activated NFκB complex binds IL6 gene promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1075, "y" : 660 }, "minX" : 1040, "maxX" : 1080, "minY" : 620, "maxY" : 671, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1040, "y" : 671 }, "to" : { "x" : 1075, "y" : 660 } }, { "from" : { "x" : 1075, "y" : 660 }, "to" : { "x" : 1058, "y" : 620 } } ], "endShape" : { "a" : { "x" : 1064, "y" : 625 }, "b" : { "x" : 1058, "y" : 620 }, "c" : { "x" : 1057, "y" : 628 }, "type" : "ARROW", "centre" : { "x" : 1057, "y" : 628 } }, "reactionShape" : { "c" : { "x" : 1075, "y" : 660 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1075, "y" : 660 } }, "inputs" : [ { "id" : 758, "points" : [ { "x" : 1030, "y" : 694 } ] }, { "id" : 3156, "points" : [ { "x" : 986, "y" : 632 } ] } ], "outputs" : [ { "id" : 811 } ] }, { "id" : 1875, "reactomeId" : 2730599, "displayName" : "Phosphorylated STAT3 Dimer Translocates to the Nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1176, "y" : 766 }, "minX" : 1117, "maxX" : 1515, "minY" : 760, "maxY" : 772, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1515, "y" : 771 }, "to" : { "x" : 1176, "y" : 766 } }, { "from" : { "x" : 1176, "y" : 766 }, "to" : { "x" : 1117, "y" : 766 } } ], "endShape" : { "a" : { "x" : 1124, "y" : 762 }, "b" : { "x" : 1117, "y" : 766 }, "c" : { "x" : 1124, "y" : 770 }, "type" : "ARROW", "centre" : { "x" : 1124, "y" : 770 } }, "reactionShape" : { "a" : { "x" : 1170, "y" : 760 }, "b" : { "x" : 1182, "y" : 772 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1176, "y" : 766 } }, "inputs" : [ { "id" : 190 } ], "outputs" : [ { "id" : 192 } ] }, { "id" : 19, "reactomeId" : 1112514, "displayName" : "JAK activation", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1711, "y" : 296 }, "minX" : 1685, "maxX" : 1729, "minY" : 290, "maxY" : 302, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 1685, "y" : 293 }, "to" : { "x" : 1711, "y" : 296 } }, { "from" : { "x" : 1711, "y" : 296 }, "to" : { "x" : 1729, "y" : 295 } } ], "reactionShape" : { "a" : { "x" : 1705, "y" : 290 }, "b" : { "x" : 1717, "y" : 302 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 1711, "y" : 296 } }, "inputs" : [ { "id" : 16, "points" : [ { "x" : 1657, "y" : 295 } ] }, { "id" : 20, "points" : [ { "x" : 1658, "y" : 364 } ], "stoichiometry" : 12 } ], "outputs" : [ { "id" : 21, "points" : [ { "x" : 1748, "y" : 362 } ], "stoichiometry" : 12 }, { "id" : 22, "points" : [ { "x" : 1753, "y" : 297 } ] } ] }, { "id" : 404, "reactomeId" : 9935552, "displayName" : "Ubiquitinated CDH1 translocates to lysosomes for degradation", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 707, "y" : 1864 }, "minX" : 699, "maxX" : 788, "minY" : 1858, "maxY" : 1981, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 699, "y" : 1981 }, "to" : { "x" : 707, "y" : 1864 } }, { "from" : { "x" : 707, "y" : 1864 }, "to" : { "x" : 788, "y" : 1860 } } ], "endShape" : { "a" : { "x" : 781, "y" : 1864 }, "b" : { "x" : 788, "y" : 1860 }, "c" : { "x" : 781, "y" : 1856 }, "type" : "ARROW", "centre" : { "x" : 781, "y" : 1856 } }, "reactionShape" : { "a" : { "x" : 701, "y" : 1858 }, "b" : { "x" : 713, "y" : 1870 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 707, "y" : 1864 } }, "inputs" : [ { "id" : 402 } ], "outputs" : [ { "id" : 405 } ] }, { "id" : 3157, "reactomeId" : 9958875, "displayName" : "NFκB stimulates IL6 gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 902, "y" : 556 }, "minX" : 674, "maxX" : 986, "minY" : 234, "maxY" : 632, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 986, "y" : 632 }, "to" : { "x" : 902, "y" : 556 } }, { "from" : { "x" : 902, "y" : 556 }, "to" : { "x" : 812, "y" : 537 } }, { "from" : { "x" : 812, "y" : 537 }, "to" : { "x" : 674, "y" : 234 } } ], "endShape" : { "a" : { "x" : 681, "y" : 239 }, "b" : { "x" : 674, "y" : 234 }, "c" : { "x" : 673, "y" : 242 }, "type" : "ARROW", "centre" : { "x" : 673, "y" : 242 } }, "reactionShape" : { "a" : { "x" : 896, "y" : 550 }, "b" : { "x" : 908, "y" : 562 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 902, "y" : 556 } }, "inputs" : [ { "id" : 3156 } ], "outputs" : [ { "id" : 4 } ], "activators" : [ { "id" : 811, "points" : [ { "x" : 998, "y" : 582 } ] } ] }, { "id" : 341, "reactomeId" : 9958889, "displayName" : "SRC phosphorylates CDH1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 400, "y" : 1603 }, "minX" : 394, "maxX" : 406, "minY" : 1565, "maxY" : 1646, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 397, "y" : 1565 }, "to" : { "x" : 400, "y" : 1603 } }, { "from" : { "x" : 400, "y" : 1603 }, "to" : { "x" : 397, "y" : 1646 } } ], "reactionShape" : { "a" : { "x" : 394, "y" : 1597 }, "b" : { "x" : 406, "y" : 1609 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 400, "y" : 1603 } }, "inputs" : [ { "id" : 342, "points" : [ { "x" : 456, "y" : 1557 } ], "stoichiometry" : 10 }, { "id" : 343, "points" : [ { "x" : 421, "y" : 1530 } ] } ], "outputs" : [ { "id" : 344, "points" : [ { "x" : 607, "y" : 1689 } ], "stoichiometry" : 10 }, { "id" : 345, "points" : [ { "x" : 623, "y" : 1650 } ], "stoichiometry" : 2 }, { "id" : 346, "points" : [ { "x" : 407, "y" : 1717 } ] }, { "id" : 347, "points" : [ { "x" : 608, "y" : 1598 } ] } ], "catalysts" : [ { "id" : 348, "points" : [ { "x" : 369, "y" : 1440 }, { "x" : 326, "y" : 1455 }, { "x" : 326, "y" : 1603 } ] } ] }, { "id" : 407, "reactomeId" : 9935547, "displayName" : "Lysosomal degradation of ubiquitinated CDH1", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 708, "y" : 1813 }, "minX" : 609, "maxX" : 814, "minY" : 1807, "maxY" : 1839, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 814, "y" : 1839 }, "to" : { "x" : 708, "y" : 1813 } }, { "from" : { "x" : 708, "y" : 1813 }, "to" : { "x" : 609, "y" : 1813 } } ], "endShape" : { "a" : { "x" : 616, "y" : 1809 }, "b" : { "x" : 609, "y" : 1813 }, "c" : { "x" : 616, "y" : 1817 }, "type" : "ARROW", "centre" : { "x" : 616, "y" : 1817 } }, "reactionShape" : { "a" : { "x" : 702, "y" : 1807 }, "b" : { "x" : 714, "y" : 1819 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 708, "y" : 1813 } }, "inputs" : [ { "id" : 405 } ], "outputs" : [ { "id" : 380 } ], "catalysts" : [ { "id" : 408, "points" : [ { "x" : 872, "y" : 1787 } ] } ] }, { "id" : 3295, "reactomeId" : 1067646, "displayName" : "JAK1,JAK2,(TYK2) bind IL6ST", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 925, "y" : 308 }, "minX" : 881, "maxX" : 962, "minY" : 295, "maxY" : 337, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 881, "y" : 337 }, "to" : { "x" : 925, "y" : 308 } }, { "from" : { "x" : 925, "y" : 308 }, "to" : { "x" : 962, "y" : 295 } } ], "endShape" : { "a" : { "x" : 957, "y" : 301 }, "b" : { "x" : 962, "y" : 295 }, "c" : { "x" : 954, "y" : 294 }, "type" : "ARROW", "centre" : { "x" : 954, "y" : 294 } }, "reactionShape" : { "c" : { "x" : 925, "y" : 308 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 925, "y" : 308 } }, "inputs" : [ { "id" : 3296, "points" : [ { "x" : 892, "y" : 377 } ] }, { "id" : 3297, "points" : [ { "x" : 863, "y" : 309 } ] } ], "outputs" : [ { "id" : 10 } ] }, { "id" : 1441, "reactomeId" : 9958874, "displayName" : "26S proteasome degrades ubiquitinated RAC1, CDC42", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 620, "y" : 405 }, "minX" : 571, "maxX" : 668, "minY" : 399, "maxY" : 450, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 571, "y" : 450 }, "to" : { "x" : 620, "y" : 405 } }, { "from" : { "x" : 620, "y" : 405 }, "to" : { "x" : 668, "y" : 409 } } ], "reactionShape" : { "a" : { "x" : 614, "y" : 399 }, "b" : { "x" : 626, "y" : 411 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 620, "y" : 405 } }, "inputs" : [ { "id" : 1422 } ], "outputs" : [ { "id" : 1425, "points" : [ { "x" : 657, "y" : 384 } ] }, { "id" : 5308, "points" : [ { "x" : 688, "y" : 419 } ] } ], "catalysts" : [ { "id" : 1442, "points" : [ { "x" : 659, "y" : 463 } ] } ] }, { "id" : 995, "reactomeId" : 9934410, "displayName" : "CDH1 forms homotypic trans-dimers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 337, "y" : 935 }, "minX" : 332, "maxX" : 342, "minY" : 894, "maxY" : 967, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 333, "y" : 967 }, "to" : { "x" : 337, "y" : 935 } }, { "from" : { "x" : 337, "y" : 935 }, "to" : { "x" : 341, "y" : 894 } } ], "endShape" : { "a" : { "x" : 344, "y" : 901 }, "b" : { "x" : 341, "y" : 894 }, "c" : { "x" : 336, "y" : 901 }, "type" : "ARROW", "centre" : { "x" : 336, "y" : 901 } }, "reactionShape" : { "c" : { "x" : 337, "y" : 935 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 337, "y" : 935 } }, "inputs" : [ { "id" : 996, "points" : [ { "x" : 341, "y" : 1055 } ], "stoichiometry" : 120 }, { "id" : 997, "points" : [ { "x" : 275, "y" : 997 } ] }, { "id" : 998, "points" : [ { "x" : 376, "y" : 981 } ] } ], "outputs" : [ { "id" : 999 } ] }, { "id" : 38, "reactomeId" : 1112510, "displayName" : "IL6ST is tyrosine phosphorylated", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1921, "y" : 294 }, "minX" : 1896, "maxX" : 1950, "minY" : 288, "maxY" : 300, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 1896, "y" : 291 }, "to" : { "x" : 1921, "y" : 294 } }, { "from" : { "x" : 1921, "y" : 294 }, "to" : { "x" : 1950, "y" : 292 } } ], "reactionShape" : { "a" : { "x" : 1915, "y" : 288 }, "b" : { "x" : 1927, "y" : 300 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 1921, "y" : 294 } }, "inputs" : [ { "id" : 22, "points" : [ { "x" : 1863, "y" : 295 } ] }, { "id" : 39, "points" : [ { "x" : 1881, "y" : 363 } ], "stoichiometry" : 20 } ], "outputs" : [ { "id" : 40, "points" : [ { "x" : 1969, "y" : 374 } ], "stoichiometry" : 20 }, { "id" : 41, "points" : [ { "x" : 1987, "y" : 293 } ] } ] }, { "id" : 168, "reactomeId" : 9958871, "displayName" : "Tyrosine phosphorylation of STAT3 by IL6 receptor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2094, "y" : 676 }, "minX" : 2088, "maxX" : 2100, "minY" : 645, "maxY" : 709, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2095, "y" : 645 }, "to" : { "x" : 2094, "y" : 676 } }, { "from" : { "x" : 2094, "y" : 676 }, "to" : { "x" : 2089, "y" : 709 } } ], "reactionShape" : { "a" : { "x" : 2088, "y" : 670 }, "b" : { "x" : 2100, "y" : 682 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2094, "y" : 676 } }, "inputs" : [ { "id" : 137, "points" : [ { "x" : 2082, "y" : 608 } ] }, { "id" : 169, "points" : [ { "x" : 2054, "y" : 645 } ] } ], "outputs" : [ { "id" : 170, "points" : [ { "x" : 2043, "y" : 705 } ] }, { "id" : 171, "points" : [ { "x" : 2082, "y" : 737 } ] } ], "catalysts" : [ { "id" : 137, "points" : [ { "x" : 2093, "y" : 608 }, { "x" : 2138, "y" : 673 } ] } ] }, { "id" : 1000, "reactomeId" : 9934411, "displayName" : "CDH1 forms cis-clusters", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 535, "y" : 1409 }, "minX" : 429, "maxX" : 540, "minY" : 1359, "maxY" : 1460, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 471, "y" : 1460 }, "to" : { "x" : 535, "y" : 1409 } }, { "from" : { "x" : 535, "y" : 1409 }, "to" : { "x" : 429, "y" : 1359 } } ], "endShape" : { "a" : { "x" : 437, "y" : 1358 }, "b" : { "x" : 429, "y" : 1359 }, "c" : { "x" : 434, "y" : 1366 }, "type" : "ARROW", "centre" : { "x" : 434, "y" : 1366 } }, "reactionShape" : { "c" : { "x" : 535, "y" : 1409 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 535, "y" : 1409 } }, "inputs" : [ { "id" : 343, "stoichiometry" : 5 } ], "outputs" : [ { "id" : 1001 } ] }, { "id" : 1002, "reactomeId" : 9934486, "displayName" : "CDH1-associated CTNNA1 binds F-actin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 419, "y" : 1236 }, "minX" : 406, "maxX" : 430, "minY" : 1199, "maxY" : 1266, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 430, "y" : 1266 }, "to" : { "x" : 419, "y" : 1236 } }, { "from" : { "x" : 419, "y" : 1236 }, "to" : { "x" : 406, "y" : 1199 } } ], "endShape" : { "a" : { "x" : 412, "y" : 1204 }, "b" : { "x" : 406, "y" : 1199 }, "c" : { "x" : 405, "y" : 1207 }, "type" : "ARROW", "centre" : { "x" : 405, "y" : 1207 } }, "reactionShape" : { "c" : { "x" : 419, "y" : 1236 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 419, "y" : 1236 } }, "inputs" : [ { "id" : 1001, "points" : [ { "x" : 404, "y" : 1320 } ] }, { "id" : 1003, "points" : [ { "x" : 634, "y" : 1270 } ], "stoichiometry" : 5 } ], "outputs" : [ { "id" : 1004 } ] }, { "id" : 2732, "reactomeId" : 9958891, "displayName" : "SRC downregulates CDH11", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 498, "y" : 847 }, "minX" : 473, "maxX" : 574, "minY" : 806, "maxY" : 853, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 473, "y" : 806 }, "to" : { "x" : 498, "y" : 847 } }, { "from" : { "x" : 498, "y" : 847 }, "to" : { "x" : 574, "y" : 850 } } ], "reactionShape" : { "a" : { "x" : 492, "y" : 841 }, "b" : { "x" : 504, "y" : 853 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 498, "y" : 847 } }, "inputs" : [ { "id" : 1074 } ], "outputs" : [ { "id" : 5048, "points" : [ { "x" : 668, "y" : 811 } ] }, { "id" : 5133, "points" : [ { "x" : 679, "y" : 839 } ] }, { "id" : 5135, "points" : [ { "x" : 547, "y" : 888 } ] } ], "activators" : [ { "id" : 348, "points" : [ { "x" : 447, "y" : 1394 }, { "x" : 525, "y" : 1345 } ] } ] }, { "id" : 1005, "reactomeId" : 9934294, "displayName" : "CDH1-associated CTNNA1 binds VCL", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 432, "y" : 1092 }, "minX" : 427, "maxX" : 437, "minY" : 1027, "maxY" : 1110, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 434, "y" : 1110 }, "to" : { "x" : 432, "y" : 1092 } }, { "from" : { "x" : 432, "y" : 1092 }, "to" : { "x" : 428, "y" : 1027 } } ], "endShape" : { "a" : { "x" : 432, "y" : 1034 }, "b" : { "x" : 428, "y" : 1027 }, "c" : { "x" : 424, "y" : 1034 }, "type" : "ARROW", "centre" : { "x" : 424, "y" : 1034 } }, "reactionShape" : { "c" : { "x" : 432, "y" : 1092 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 432, "y" : 1092 } }, "inputs" : [ { "id" : 1006, "points" : [ { "x" : 628, "y" : 1176 } ], "stoichiometry" : 5 }, { "id" : 1004, "points" : [ { "x" : 409, "y" : 1155 } ] } ], "outputs" : [ { "id" : 998 } ] }, { "id" : 1072, "reactomeId" : 9833674, "displayName" : "CDH11 forms homotypic trans dimers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 346, "y" : 718 }, "minX" : 341, "maxX" : 351, "minY" : 689, "maxY" : 744, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 349, "y" : 744 }, "to" : { "x" : 346, "y" : 718 } }, { "from" : { "x" : 346, "y" : 718 }, "to" : { "x" : 351, "y" : 689 } } ], "endShape" : { "a" : { "x" : 354, "y" : 697 }, "b" : { "x" : 351, "y" : 689 }, "c" : { "x" : 346, "y" : 695 }, "type" : "ARROW", "centre" : { "x" : 346, "y" : 695 } }, "reactionShape" : { "c" : { "x" : 346, "y" : 718 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 346, "y" : 718 } }, "inputs" : [ { "id" : 1073, "points" : [ { "x" : 286, "y" : 774 } ] }, { "id" : 1074, "points" : [ { "x" : 394, "y" : 752 } ] }, { "id" : 1077, "points" : [ { "x" : 356, "y" : 805 } ], "stoichiometry" : 24 } ], "outputs" : [ { "id" : 1076 } ] }, { "id" : 756, "reactomeId" : 9958872, "displayName" : "RAC1, CDC42 activate NFκB", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 904, "y" : 710 }, "minX" : 857, "maxX" : 959, "minY" : 704, "maxY" : 716, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 857, "y" : 706 }, "to" : { "x" : 904, "y" : 710 } }, { "from" : { "x" : 904, "y" : 710 }, "to" : { "x" : 959, "y" : 709 } } ], "endShape" : { "a" : { "x" : 952, "y" : 713 }, "b" : { "x" : 959, "y" : 709 }, "c" : { "x" : 952, "y" : 705 }, "type" : "ARROW", "centre" : { "x" : 952, "y" : 705 } }, "reactionShape" : { "a" : { "x" : 898, "y" : 704 }, "b" : { "x" : 910, "y" : 716 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 904, "y" : 710 } }, "inputs" : [ { "id" : 757 } ], "outputs" : [ { "id" : 758 } ], "activators" : [ { "id" : 759, "points" : [ { "x" : 653, "y" : 935 }, { "x" : 802, "y" : 893 } ] } ] }, { "id" : 187, "reactomeId" : 9958877, "displayName" : "p-Y705-STAT3 dissociates from IL6 receptor", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1889, "y" : 692 }, "minX" : 1863, "maxX" : 2005, "minY" : 634, "maxY" : 737, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 2005, "y" : 737 }, "to" : { "x" : 1889, "y" : 692 } }, { "from" : { "x" : 1889, "y" : 692 }, "to" : { "x" : 1863, "y" : 634 } } ], "reactionShape" : { "c" : { "x" : 1889, "y" : 692 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 1889, "y" : 692 } }, "inputs" : [ { "id" : 171 } ], "outputs" : [ { "id" : 41, "points" : [ { "x" : 2033, "y" : 332 } ] }, { "id" : 188, "points" : [ { "x" : 1800, "y" : 632 } ] } ] }, { "id" : 379, "reactomeId" : 9934755, "displayName" : "CBLL1 binds p-Y-CDH1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 405, "y" : 1819 }, "minX" : 395, "maxX" : 411, "minY" : 1793, "maxY" : 1863, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 404, "y" : 1793 }, "to" : { "x" : 405, "y" : 1819 } }, { "from" : { "x" : 405, "y" : 1819 }, "to" : { "x" : 395, "y" : 1863 } } ], "reactionShape" : { "c" : { "x" : 405, "y" : 1819 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 405, "y" : 1819 } }, "inputs" : [ { "id" : 380, "points" : [ { "x" : 489, "y" : 1805 } ], "stoichiometry" : 2 }, { "id" : 346, "points" : [ { "x" : 407, "y" : 1772 } ] } ], "outputs" : [ { "id" : 381, "points" : [ { "x" : 479, "y" : 1866 } ], "stoichiometry" : 2 }, { "id" : 382, "points" : [ { "x" : 395, "y" : 1931 } ], "stoichiometry" : 2 } ] } ], "compartments" : [ { "id" : 1056, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 154, "y" : 1201 }, "minX" : 0, "maxX" : 308, "minY" : 242, "maxY" : 2160, "prop" : { "x" : 0, "y" : 242, "width" : 308, "height" : 1918 }, "textPosition" : { "x" : 13, "y" : 2106 }, "insets" : { "x" : 10, "y" : 286, "width" : 281, "height" : 1857 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 997, 999, 1073, 1076, 1188 ] }, { "id" : 208, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1038, "y" : 737 }, "minX" : 896, "maxX" : 1180, "minY" : 553, "maxY" : 922, "prop" : { "x" : 896, "y" : 553, "width" : 284, "height" : 369 }, "textPosition" : { "x" : 914, "y" : 872 }, "insets" : { "x" : 902, "y" : 559, "width" : 269, "height" : 353 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 192, 758, 756, 811, 3155, 3156, 3157, 1875 ] }, { "id" : 1, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1269, "y" : 1196 }, "minX" : 385, "maxX" : 2153, "minY" : 241, "maxY" : 2152, "prop" : { "x" : 385, "y" : 241, "width" : 1768, "height" : 1911 }, "textPosition" : { "x" : 603, "y" : 2092 }, "insets" : { "x" : 600, "y" : 279, "width" : 1519, "height" : 1853 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 3, 5, 11, 10, 13, 16, 15, 18, 14, 19, 20, 21, 22, 17, 38, 39, 41, 40, 136, 137, 135, 169, 170, 171, 168, 187, 188, 190, 208, 341, 344, 346, 379, 382, 381, 398, 399, 400, 401, 403, 404, 406, 345, 380, 348, 342, 347, 343, 407, 757, 759, 998, 1000, 1001, 1002, 1003, 1004, 1005, 1006, 1022, 1023, 1074, 1184, 1189, 1422, 1423, 1425, 1441, 1442, 1874, 2732, 3083, 3084, 3085, 3086, 3087, 3138, 3295, 3296, 3297, 4813, 4844, 5015, 4999, 4998, 5048, 5133, 5135, 5137, 5155, 5156, 5308 ] }, { "id" : 403, "reactomeId" : 171043, "displayName" : "early endosome lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 806, "y" : 2018 }, "minX" : 684, "maxX" : 929, "minY" : 1960, "maxY" : 2077, "prop" : { "x" : 684, "y" : 1960, "width" : 245, "height" : 117 }, "textPosition" : { "x" : 725, "y" : 2026 }, "insets" : { "x" : 704, "y" : 1972, "width" : 215, "height" : 95 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 402 ] }, { "id" : 406, "reactomeId" : 161320, "displayName" : "lysosomal lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 939, "y" : 1830 }, "minX" : 845, "maxX" : 1034, "minY" : 1726, "maxY" : 1934, "prop" : { "x" : 845, "y" : 1726, "width" : 189, "height" : 208 }, "textPosition" : { "x" : 865, "y" : 1879 }, "insets" : { "x" : 862, "y" : 1740, "width" : 155, "height" : 187 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 405, 408 ] } ], "notes" : [ { "id" : 4844, "displayName" : "Downregulation", "renderableClass" : "Note", "position" : { "x" : 887, "y" : 479 }, "minX" : 834, "maxX" : 940, "minY" : 465, "maxY" : 494, "prop" : { "x" : 834, "y" : 465, "width" : 106, "height" : 29 }, "textPosition" : { "x" : 834, "y" : 469 } } ], "links" : [ { "id" : 17, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1272, "y" : 300 }, "minX" : 1230, "maxX" : 1314, "minY" : 294, "maxY" : 306, "segments" : [ { "from" : { "x" : 1230, "y" : 304 }, "to" : { "x" : 1314, "y" : 296 } } ], "reactionShape" : { "a" : { "x" : 1266, "y" : 294 }, "b" : { "x" : 1278, "y" : 306 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1272, "y" : 300 } }, "inputs" : [ { "id" : 13 } ], "outputs" : [ { "id" : 15 } ] }, { "id" : 18, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1153, "y" : 382 }, "minX" : 1110, "maxX" : 1328, "minY" : 316, "maxY" : 388, "segments" : [ { "from" : { "x" : 1110, "y" : 329 }, "to" : { "x" : 1153, "y" : 382 } }, { "from" : { "x" : 1153, "y" : 382 }, "to" : { "x" : 1328, "y" : 316 } } ], "reactionShape" : { "a" : { "x" : 1147, "y" : 376 }, "b" : { "x" : 1159, "y" : 388 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1153, "y" : 382 } }, "inputs" : [ { "id" : 11 } ], "outputs" : [ { "id" : 15 } ] }, { "id" : 5156, "renderableClass" : "Interaction", "position" : { "x" : 1019, "y" : 375 }, "minX" : 1001, "maxX" : 1037, "minY" : 321, "maxY" : 430, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1037, "y" : 430 }, "to" : { "x" : 1001, "y" : 321 } } ], "endShape" : { "a" : { "x" : 1007, "y" : 326 }, "b" : { "x" : 1001, "y" : 321 }, "c" : { "x" : 999, "y" : 329 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 999, "y" : 329 } }, "reactionShape" : { "a" : { "x" : 1013, "y" : 369 }, "b" : { "x" : 1025, "y" : 381 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1019, "y" : 375 } }, "inputs" : [ { "id" : 5155 } ], "outputs" : [ { "id" : 10 } ] }, { "id" : 1189, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 559, "y" : 773 }, "minX" : 397, "maxX" : 565, "minY" : 617, "maxY" : 869, "segments" : [ { "from" : { "x" : 419, "y" : 869 }, "to" : { "x" : 557, "y" : 864 } }, { "from" : { "x" : 557, "y" : 864 }, "to" : { "x" : 562, "y" : 682 } }, { "from" : { "x" : 562, "y" : 682 }, "to" : { "x" : 397, "y" : 617 } } ], "reactionShape" : { "a" : { "x" : 553, "y" : 767 }, "b" : { "x" : 565, "y" : 779 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 559, "y" : 773 } }, "inputs" : [ { "id" : 999 } ], "outputs" : [ { "id" : 1188 } ] }, { "id" : 1190, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 363, "y" : 633 }, "minX" : 357, "maxX" : 369, "minY" : 617, "maxY" : 649, "segments" : [ { "from" : { "x" : 359, "y" : 649 }, "to" : { "x" : 368, "y" : 617 } } ], "reactionShape" : { "a" : { "x" : 357, "y" : 627 }, "b" : { "x" : 369, "y" : 639 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 363, "y" : 633 } }, "inputs" : [ { "id" : 1076 } ], "outputs" : [ { "id" : 1188 } ] }, { "id" : 1023, "renderableClass" : "Interaction", "position" : { "x" : 574, "y" : 1499 }, "minX" : 532, "maxX" : 616, "minY" : 1493, "maxY" : 1505, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 616, "y" : 1501 }, "to" : { "x" : 532, "y" : 1497 } } ], "endShape" : { "a" : { "x" : 539, "y" : 1493 }, "b" : { "x" : 532, "y" : 1497 }, "c" : { "x" : 539, "y" : 1501 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 539, "y" : 1501 } }, "reactionShape" : { "a" : { "x" : 568, "y" : 1493 }, "b" : { "x" : 580, "y" : 1505 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 574, "y" : 1499 } }, "inputs" : [ { "id" : 1022 } ], "outputs" : [ { "id" : 343 } ] } ], "shadows" : [ { "id" : 5309, "reactomeId" : 9958810, "displayName" : "SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST)", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 664, "y" : 1425 }, "minX" : 318, "maxX" : 1010, "minY" : 748, "maxY" : 2103, "prop" : { "x" : 318, "y" : 748, "width" : 692, "height" : 1355 }, "points" : [ { "x" : 318, "y" : 748 }, { "x" : 1010, "y" : 748 }, { "x" : 1010, "y" : 2103 }, { "x" : 318, "y" : 2103 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 2177, "minY" : 0, "maxY" : 2160, "disease" : false }