{ "dbId" : 9843743, "stableId" : "R-HSA-9843743", "displayName" : "Transcriptional regulation of brown and beige adipocyte differentiation", "nodes" : [ { "id" : 5441, "reactomeId" : 9843266, "displayName" : "PPARG:RXRA", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1120, "y" : 622 }, "minX" : 1078, "maxX" : 1162, "minY" : 611, "maxY" : 676, "prop" : { "x" : 1078, "y" : 611, "width" : 84, "height" : 23 }, "textPosition" : { "x" : 1078, "y" : 612 }, "connectors" : [ { "edgeId" : 5440, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1111, "y" : 640 }, "to" : { "x" : 1079, "y" : 676 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 1089, "y" : 652 }, "b" : { "x" : 1101, "y" : 664 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1095, "y" : 658 } } } } ] }, { "id" : 3842, "reactomeId" : 9844669, "displayName" : "EBF2, EBF2:Blnc1 lncRNA:HNRNPU:Activated PPARG:RXRA:PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, PPARGC1A gene)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1174, "y" : 884 }, "minX" : 1123, "maxX" : 1225, "minY" : 804, "maxY" : 965, "prop" : { "x" : 1123, "y" : 804, "width" : 102, "height" : 161 }, "textPosition" : { "x" : 1123, "y" : 804 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 5440, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5442, "reactomeId" : 9844664, "displayName" : "RXRA natural ligands", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1192, "y" : 674 }, "minX" : 1079, "maxX" : 1238, "minY" : 656, "maxY" : 693, "prop" : { "x" : 1146, "y" : 656, "width" : 92, "height" : 37 }, "textPosition" : { "x" : 1146, "y" : 657 }, "connectors" : [ { "edgeId" : 5440, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1140, "y" : 674 }, "to" : { "x" : 1079, "y" : 676 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 1103, "y" : 669 }, "b" : { "x" : 1115, "y" : 681 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1109, "y" : 675 } } } } ] }, { "id" : 5443, "reactomeId" : 9844662, "displayName" : "Brown,beige adipocyte-specific coactivators of PPARG:RXRA", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 518, "y" : 460 }, "minX" : 459, "maxX" : 1079, "minY" : 428, "maxY" : 676, "prop" : { "x" : 459, "y" : 428, "width" : 118, "height" : 65 }, "textPosition" : { "x" : 465, "y" : 422 }, "connectors" : [ { "edgeId" : 5440, "type" : "INPUT", "segments" : [ { "from" : { "x" : 583, "y" : 482 }, "to" : { "x" : 1079, "y" : 676 } } ], "stoichiometry" : { "value" : 10, "shape" : { "a" : { "x" : 825, "y" : 573 }, "b" : { "x" : 837, "y" : 585 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 831, "y" : 579 } } } } ] }, { "id" : 964, "reactomeId" : 4686147, "displayName" : "PPARGC1A gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 249, "y" : 253 }, "minX" : 213, "maxX" : 292, "minY" : 225, "maxY" : 279, "prop" : { "x" : 213, "y" : 227, "width" : 72, "height" : 52 }, "textPosition" : { "x" : 216, "y" : 254 }, "connectors" : [ { "edgeId" : 5228, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 292, "y" : 225 }, "b" : { "x" : 285, "y" : 229 }, "c" : { "x" : 292, "y" : 233 }, "type" : "ARROW", "centre" : { "x" : 292, "y" : 233 } } }, { "id" : 5445, "reactomeId" : 9844661, "displayName" : "EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, PPARGC1A gene)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 827, "y" : 667 }, "minX" : 760, "maxX" : 1079, "minY" : 621, "maxY" : 714, "prop" : { "x" : 760, "y" : 621, "width" : 134, "height" : 93 }, "textPosition" : { "x" : 762, "y" : 615 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 5440, "type" : "INPUT", "segments" : [ { "from" : { "x" : 900, "y" : 669 }, "to" : { "x" : 1079, "y" : 676 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5320, "reactomeId" : 9844503, "displayName" : "EBF2, EBF2:Blnc1 lncRNA:HNRNPU: PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, DIO2 gene, ELOVL3 gene)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 421, "y" : 785 }, "minX" : 366, "maxX" : 477, "minY" : 725, "maxY" : 904, "prop" : { "x" : 366, "y" : 725, "width" : 111, "height" : 120 }, "textPosition" : { "x" : 366, "y" : 719 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 5319, "type" : "INPUT", "segments" : [ { "from" : { "x" : 402, "y" : 851 }, "to" : { "x" : 384, "y" : 904 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5451, "reactomeId" : 9844666, "displayName" : "PPARG natural ligands", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 986, "y" : 587 }, "minX" : 937, "maxX" : 1079, "minY" : 569, "maxY" : 676, "prop" : { "x" : 937, "y" : 569, "width" : 98, "height" : 37 }, "textPosition" : { "x" : 935, "y" : 570 }, "connectors" : [ { "edgeId" : 5440, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1005, "y" : 612 }, "to" : { "x" : 1079, "y" : 676 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 1036, "y" : 638 }, "b" : { "x" : 1048, "y" : 650 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1042, "y" : 644 } } } } ] }, { "id" : 3342, "reactomeId" : 9844471, "displayName" : "CIDEA gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1352, "y" : 885 }, "minX" : 1314, "maxX" : 1398, "minY" : 857, "maxY" : 911, "prop" : { "x" : 1314, "y" : 859, "width" : 77, "height" : 52 }, "textPosition" : { "x" : 1328, "y" : 886 }, "connectors" : [ { "edgeId" : 5230, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1398, "y" : 857 }, "b" : { "x" : 1391, "y" : 861 }, "c" : { "x" : 1398, "y" : 865 }, "type" : "ARROW", "centre" : { "x" : 1398, "y" : 865 } } }, { "id" : 3343, "reactomeId" : 8856626, "displayName" : "CIDEA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1648, "y" : 632 }, "minX" : 1626, "maxX" : 1676, "minY" : 615, "maxY" : 644, "prop" : { "x" : 1626, "y" : 621, "width" : 44, "height" : 23 }, "textPosition" : { "x" : 1626, "y" : 622 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1670, "y" : 621 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1670, "y" : 621 } } }, "connectors" : [ { "edgeId" : 5230, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 4816, "reactomeId" : 9844814, "displayName" : "EBF2, EBF2:Blnc1 lncRNA:HNRNPU, Activated PPARG:RXRA:UCP1 gene", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1058, "y" : 297 }, "minX" : 781, "maxX" : 1121, "minY" : 259, "maxY" : 335, "prop" : { "x" : 995, "y" : 260, "width" : 126, "height" : 75 }, "textPosition" : { "x" : 998, "y" : 266 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 3070, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 989, "y" : 289 }, "to" : { "x" : 781, "y" : 262 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 788, "y" : 259 }, "b" : { "x" : 781, "y" : 262 }, "c" : { "x" : 787, "y" : 267 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 787, "y" : 267 } } } ] }, { "id" : 2841, "reactomeId" : 9844511, "displayName" : "ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PRDM16 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 227, "y" : 664 }, "minX" : 167, "maxX" : 294, "minY" : 421, "maxY" : 695, "prop" : { "x" : 167, "y" : 634, "width" : 121, "height" : 61 }, "textPosition" : { "x" : 172, "y" : 632 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 288, "y" : 634 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 288, "y" : 634 } } }, "connectors" : [ { "edgeId" : 2840, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 222, "y" : 631 }, "to" : { "x" : 193, "y" : 422 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 189, "y" : 423 }, "b" : { "x" : 197, "y" : 421 }, "c" : { "x" : 193, "y" : 422 }, "type" : "STOP", "centre" : { "x" : 193, "y" : 422 } } } ] }, { "id" : 1500, "reactomeId" : 206654, "displayName" : "p-2S-SMAD1:p-2S-SMAD1:SMAD4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 216, "y" : 784 }, "minX" : 170, "maxX" : 269, "minY" : 754, "maxY" : 835, "prop" : { "x" : 170, "y" : 760, "width" : 93, "height" : 49 }, "textPosition" : { "x" : 173, "y" : 760 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 263, "y" : 760 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 263, "y" : 760 } } }, "connectors" : [ { "edgeId" : 1499, "type" : "INPUT", "segments" : [ { "from" : { "x" : 216, "y" : 812 }, "to" : { "x" : 217, "y" : 835 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1501, "reactomeId" : 9844431, "displayName" : "ZNF423:p-2S-SMAD1:p-2S-SMAD1:SMAD4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 272, "y" : 976 }, "minX" : 202, "maxX" : 424, "minY" : 946, "maxY" : 996, "prop" : { "x" : 202, "y" : 957, "width" : 140, "height" : 39 }, "textPosition" : { "x" : 202, "y" : 961 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 342, "y" : 957 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 342, "y" : 957 } } }, "connectors" : [ { "edgeId" : 5319, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 345, "y" : 963 }, "to" : { "x" : 423, "y" : 950 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 422, "y" : 946 }, "b" : { "x" : 424, "y" : 954 }, "c" : { "x" : 423, "y" : 950 }, "type" : "STOP", "centre" : { "x" : 423, "y" : 950 } } }, { "edgeId" : 1499, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 3038, "reactomeId" : 5640195, "displayName" : "PPARA gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 850, "y" : 763 }, "minX" : 810, "maxX" : 897, "minY" : 735, "maxY" : 789, "prop" : { "x" : 810, "y" : 737, "width" : 80, "height" : 52 }, "textPosition" : { "x" : 824, "y" : 764 }, "connectors" : [ { "edgeId" : 3037, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 897, "y" : 735 }, "b" : { "x" : 890, "y" : 739 }, "c" : { "x" : 897, "y" : 743 }, "type" : "ARROW", "centre" : { "x" : 897, "y" : 743 } } }, { "id" : 5470, "reactomeId" : 9844529, "displayName" : "ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, UCP1 gene, (CIDEA gene, DIO2 gene)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 699, "y" : 990 }, "minX" : 636, "maxX" : 830, "minY" : 944, "maxY" : 1057, "prop" : { "x" : 636, "y" : 944, "width" : 126, "height" : 93 }, "textPosition" : { "x" : 635, "y" : 945 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 5469, "type" : "INPUT", "segments" : [ { "from" : { "x" : 768, "y" : 1022 }, "to" : { "x" : 830, "y" : 1057 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 2270, "reactomeId" : 9844412, "displayName" : "ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, DIO2 gene, ELOVL3 gene)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 550, "y" : 980 }, "minX" : 499, "maxX" : 601, "minY" : 909, "maxY" : 1052, "prop" : { "x" : 499, "y" : 909, "width" : 102, "height" : 143 }, "textPosition" : { "x" : 499, "y" : 907 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 5319, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1758, "reactomeId" : 9844453, "displayName" : "EBF2,EBF2:Blnc1 lncRNA:HNRNPU", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 655, "y" : 431 }, "minX" : 251, "maxX" : 1563, "minY" : 346, "maxY" : 847, "prop" : { "x" : 600, "y" : 413, "width" : 111, "height" : 37 }, "textPosition" : { "x" : 609, "y" : 407 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 3489, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 717, "y" : 415 }, "to" : { "x" : 869, "y" : 370 } }, { "from" : { "x" : 869, "y" : 370 }, "to" : { "x" : 1486, "y" : 446 } }, { "from" : { "x" : 1486, "y" : 446 }, "to" : { "x" : 1455, "y" : 847 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1452, "y" : 840 }, "b" : { "x" : 1455, "y" : 847 }, "c" : { "x" : 1460, "y" : 840 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1460, "y" : 840 } } }, { "edgeId" : 5413, "type" : "INPUT", "segments" : [ { "from" : { "x" : 679, "y" : 456 }, "to" : { "x" : 722, "y" : 482 } } ], "stoichiometry" : { "value" : 8, "shape" : { "a" : { "x" : 694, "y" : 463 }, "b" : { "x" : 706, "y" : 475 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 700, "y" : 469 } } } }, { "edgeId" : 5228, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 639, "y" : 456 }, "to" : { "x" : 592, "y" : 505 } }, { "from" : { "x" : 592, "y" : 505 }, "to" : { "x" : 357, "y" : 495 } }, { "from" : { "x" : 357, "y" : 495 }, "to" : { "x" : 251, "y" : 389 } }, { "from" : { "x" : 251, "y" : 389 }, "to" : { "x" : 286, "y" : 346 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 285, "y" : 354 }, "b" : { "x" : 286, "y" : 346 }, "c" : { "x" : 279, "y" : 349 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 279, "y" : 349 } } }, { "edgeId" : 5230, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 717, "y" : 417 }, "to" : { "x" : 869, "y" : 379 } }, { "from" : { "x" : 869, "y" : 379 }, "to" : { "x" : 1009, "y" : 404 } }, { "from" : { "x" : 1009, "y" : 404 }, "to" : { "x" : 1312, "y" : 695 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1304, "y" : 693 }, "b" : { "x" : 1312, "y" : 695 }, "c" : { "x" : 1310, "y" : 687 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1310, "y" : 687 } } }, { "edgeId" : 4977, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 701, "y" : 407 }, "to" : { "x" : 859, "y" : 350 } }, { "from" : { "x" : 859, "y" : 350 }, "to" : { "x" : 1503, "y" : 417 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1496, "y" : 420 }, "b" : { "x" : 1503, "y" : 417 }, "c" : { "x" : 1497, "y" : 412 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1497, "y" : 412 } } }, { "edgeId" : 5109, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 708, "y" : 407 }, "to" : { "x" : 854, "y" : 362 } }, { "from" : { "x" : 854, "y" : 362 }, "to" : { "x" : 1489, "y" : 433 } }, { "from" : { "x" : 1489, "y" : 433 }, "to" : { "x" : 1563, "y" : 502 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1555, "y" : 500 }, "b" : { "x" : 1563, "y" : 502 }, "c" : { "x" : 1561, "y" : 494 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1561, "y" : 494 } } } ] }, { "id" : 1502, "reactomeId" : 206901, "displayName" : "BMP7 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 39, "y" : 896 }, "minX" : 0, "maxX" : 211, "minY" : 879, "maxY" : 908, "prop" : { "x" : 0, "y" : 885, "width" : 78, "height" : 23 }, "textPosition" : { "x" : 16, "y" : 873 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 78, "y" : 885 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 78, "y" : 885 } } }, "connectors" : [ { "edgeId" : 1499, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 81, "y" : 895 }, "to" : { "x" : 211, "y" : 894 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 204, "y" : 898 }, "b" : { "x" : 211, "y" : 894 }, "c" : { "x" : 204, "y" : 890 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 204, "y" : 890 } } } ] }, { "id" : 3039, "reactomeId" : 400186, "displayName" : "PPARA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1074, "y" : 735 }, "minX" : 1051, "maxX" : 1104, "minY" : 718, "maxY" : 747, "prop" : { "x" : 1051, "y" : 724, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 1054, "y" : 718 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1098, "y" : 724 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1098, "y" : 724 } } }, "connectors" : [ { "edgeId" : 3037, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 3040, "reactomeId" : 9844538, "displayName" : "NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 990, "y" : 804 }, "minX" : 924, "maxX" : 1062, "minY" : 750, "maxY" : 837, "prop" : { "x" : 924, "y" : 772, "width" : 132, "height" : 65 }, "textPosition" : { "x" : 930, "y" : 774 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1056, "y" : 772 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1056, "y" : 772 } } }, "connectors" : [ { "edgeId" : 3037, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 990, "y" : 769 }, "to" : { "x" : 991, "y" : 750 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 987, "y" : 750 }, "b" : { "x" : 995, "y" : 750 }, "c" : { "x" : 991, "y" : 750 }, "type" : "STOP", "centre" : { "x" : 991, "y" : 750 } } } ] }, { "id" : 3490, "reactomeId" : 9844468, "displayName" : "DIO2 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1399, "y" : 754 }, "minX" : 1364, "maxX" : 1442, "minY" : 726, "maxY" : 780, "prop" : { "x" : 1364, "y" : 728, "width" : 71, "height" : 52 }, "textPosition" : { "x" : 1379, "y" : 755 }, "connectors" : [ { "edgeId" : 3489, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1442, "y" : 726 }, "b" : { "x" : 1435, "y" : 730 }, "c" : { "x" : 1442, "y" : 734 }, "type" : "ARROW", "centre" : { "x" : 1442, "y" : 734 } } }, { "id" : 5414, "reactomeId" : 9844457, "displayName" : "PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, COX7A1 gene, DIO2 gene, ELOVL3 gene, PPARGC1A gene)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 835, "y" : 474 }, "minX" : 722, "maxX" : 902, "minY" : 428, "maxY" : 521, "prop" : { "x" : 768, "y" : 428, "width" : 134, "height" : 93 }, "textPosition" : { "x" : 770, "y" : 422 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 5413, "type" : "INPUT", "segments" : [ { "from" : { "x" : 762, "y" : 478 }, "to" : { "x" : 722, "y" : 482 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1641, "reactomeId" : 9844436, "displayName" : "PRDM16 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 304, "y" : 587 }, "minX" : 259, "maxX" : 357, "minY" : 559, "maxY" : 613, "prop" : { "x" : 259, "y" : 561, "width" : 91, "height" : 52 }, "textPosition" : { "x" : 273, "y" : 588 }, "connectors" : [ { "edgeId" : 2840, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 357, "y" : 559 }, "b" : { "x" : 350, "y" : 563 }, "c" : { "x" : 357, "y" : 567 }, "type" : "ARROW", "centre" : { "x" : 357, "y" : 567 } } }, { "id" : 681, "reactomeId" : 3222269, "displayName" : "PRDM16", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 193, "y" : 164 }, "minX" : 164, "maxX" : 228, "minY" : 147, "maxY" : 176, "prop" : { "x" : 164, "y" : 153, "width" : 58, "height" : 23 }, "textPosition" : { "x" : 167, "y" : 147 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 222, "y" : 153 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 222, "y" : 153 } } }, "connectors" : [ { "edgeId" : 2840, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5482, "reactomeId" : 9966037, "displayName" : "DIO2 mRNA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "RNA", "position" : { "x" : 1794, "y" : 860 }, "minX" : 1743, "maxX" : 1845, "minY" : 842, "maxY" : 879, "prop" : { "x" : 1743, "y" : 842, "width" : 102, "height" : 37 }, "textPosition" : { "x" : 1755, "y" : 850 }, "connectors" : [ { "edgeId" : 3489, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1067, "reactomeId" : 442481, "displayName" : "PPARGC1A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 319, "y" : 391 }, "minX" : 284, "maxX" : 361, "minY" : 374, "maxY" : 403, "prop" : { "x" : 284, "y" : 380, "width" : 71, "height" : 23 }, "textPosition" : { "x" : 287, "y" : 374 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 355, "y" : 380 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 355, "y" : 380 } } }, "connectors" : [ { "edgeId" : 5228, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 2093, "reactomeId" : 9844437, "displayName" : "EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, COX7A1 gene, DIO2 gene, ELOVL3 gene, PPARGC1A gene)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 667, "y" : 628 }, "minX" : 611, "maxX" : 724, "minY" : 548, "maxY" : 709, "prop" : { "x" : 611, "y" : 548, "width" : 113, "height" : 161 }, "textPosition" : { "x" : 609, "y" : 548 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 5413, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1069, "reactomeId" : 71953, "displayName" : "HNRNPU", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 466, "y" : 355 }, "minX" : 436, "maxX" : 552, "minY" : 338, "maxY" : 397, "prop" : { "x" : 436, "y" : 344, "width" : 60, "height" : 23 }, "textPosition" : { "x" : 436, "y" : 345 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 496, "y" : 344 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 496, "y" : 344 } } }, "connectors" : [ { "edgeId" : 1068, "type" : "INPUT", "segments" : [ { "from" : { "x" : 489, "y" : 370 }, "to" : { "x" : 552, "y" : 397 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5229, "reactomeId" : 9844665, "displayName" : "Activated PPARG:RXRA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 556, "y" : 328 }, "minX" : 301, "maxX" : 1322, "minY" : 297, "maxY" : 692, "prop" : { "x" : 521, "y" : 303, "width" : 70, "height" : 50 }, "textPosition" : { "x" : 521, "y" : 304 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 591, "y" : 303 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 591, "y" : 303 } } }, "connectors" : [ { "edgeId" : 5228, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 518, "y" : 329 }, "to" : { "x" : 301, "y" : 339 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 308, "y" : 335 }, "b" : { "x" : 301, "y" : 339 }, "c" : { "x" : 308, "y" : 343 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 308, "y" : 343 } } }, { "edgeId" : 5230, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 594, "y" : 329 }, "to" : { "x" : 1306, "y" : 369 } }, { "from" : { "x" : 1306, "y" : 369 }, "to" : { "x" : 1318, "y" : 692 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1314, "y" : 685 }, "b" : { "x" : 1318, "y" : 692 }, "c" : { "x" : 1322, "y" : 685 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1322, "y" : 685 } } } ] }, { "id" : 1070, "reactomeId" : 9844402, "displayName" : "Blnc1 lncRNA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "RNA", "position" : { "x" : 439, "y" : 398 }, "minX" : 379, "maxX" : 552, "minY" : 379, "maxY" : 418, "prop" : { "x" : 379, "y" : 379, "width" : 121, "height" : 39 }, "textPosition" : { "x" : 395, "y" : 388 }, "connectors" : [ { "edgeId" : 1068, "type" : "INPUT", "segments" : [ { "from" : { "x" : 503, "y" : 397 }, "to" : { "x" : 552, "y" : 397 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 2414, "reactomeId" : 4657018, "displayName" : "NuRD complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 816, "y" : 1159 }, "minX" : 768, "maxX" : 1454, "minY" : 709, "maxY" : 1186, "prop" : { "x" : 768, "y" : 1148, "width" : 97, "height" : 23 }, "textPosition" : { "x" : 768, "y" : 1150 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 865, "y" : 1148 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 865, "y" : 1148 } } }, "connectors" : [ { "edgeId" : 3489, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 868, "y" : 1161 }, "to" : { "x" : 1300, "y" : 1186 } }, { "from" : { "x" : 1300, "y" : 1186 }, "to" : { "x" : 1450, "y" : 864 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1446, "y" : 862 }, "b" : { "x" : 1454, "y" : 866 }, "c" : { "x" : 1450, "y" : 864 }, "type" : "STOP", "centre" : { "x" : 1450, "y" : 864 } } }, { "edgeId" : 5230, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 868, "y" : 1158 }, "to" : { "x" : 1260, "y" : 1151 } }, { "from" : { "x" : 1260, "y" : 1151 }, "to" : { "x" : 1317, "y" : 710 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1313, "y" : 709 }, "b" : { "x" : 1321, "y" : 711 }, "c" : { "x" : 1317, "y" : 710 }, "type" : "STOP", "centre" : { "x" : 1317, "y" : 710 } } }, { "edgeId" : 5469, "type" : "INPUT", "segments" : [ { "from" : { "x" : 817, "y" : 1145 }, "to" : { "x" : 830, "y" : 1057 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 817, "y" : 1095 }, "b" : { "x" : 829, "y" : 1107 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 823, "y" : 1101 } } } } ] }, { "id" : 1071, "reactomeId" : 381317, "displayName" : "EBF2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 369, "y" : 450 }, "minX" : 351, "maxX" : 552, "minY" : 397, "maxY" : 462, "prop" : { "x" : 351, "y" : 439, "width" : 36, "height" : 23 }, "textPosition" : { "x" : 353, "y" : 433 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 387, "y" : 439 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 387, "y" : 439 } } }, "connectors" : [ { "edgeId" : 1068, "type" : "INPUT", "segments" : [ { "from" : { "x" : 390, "y" : 444 }, "to" : { "x" : 552, "y" : 397 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1455, "reactomeId" : 3222318, "displayName" : "ZNF423", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 304, "y" : 832 }, "minX" : 217, "maxX" : 1711, "minY" : 511, "maxY" : 1222, "prop" : { "x" : 274, "y" : 821, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 276, "y" : 821 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 335, "y" : 821 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 335, "y" : 821 } } }, "connectors" : [ { "edgeId" : 3489, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 306, "y" : 818 }, "to" : { "x" : 340, "y" : 678 } }, { "from" : { "x" : 340, "y" : 678 }, "to" : { "x" : 474, "y" : 684 } }, { "from" : { "x" : 474, "y" : 684 }, "to" : { "x" : 603, "y" : 891 } }, { "from" : { "x" : 603, "y" : 891 }, "to" : { "x" : 1330, "y" : 1027 } }, { "from" : { "x" : 1330, "y" : 1027 }, "to" : { "x" : 1449, "y" : 863 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1446, "y" : 861 }, "b" : { "x" : 1452, "y" : 865 }, "c" : { "x" : 1449, "y" : 863 }, "type" : "STOP", "centre" : { "x" : 1449, "y" : 863 } } }, { "edgeId" : 5319, "type" : "INPUT", "segments" : [ { "from" : { "x" : 316, "y" : 846 }, "to" : { "x" : 384, "y" : 904 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 344, "y" : 869 }, "b" : { "x" : 356, "y" : 881 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 350, "y" : 875 } } } }, { "edgeId" : 5230, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 309, "y" : 846 }, "to" : { "x" : 472, "y" : 1187 } }, { "from" : { "x" : 472, "y" : 1187 }, "to" : { "x" : 1274, "y" : 1200 } }, { "from" : { "x" : 1274, "y" : 1200 }, "to" : { "x" : 1317, "y" : 710 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1313, "y" : 710 }, "b" : { "x" : 1321, "y" : 710 }, "c" : { "x" : 1317, "y" : 710 }, "type" : "STOP", "centre" : { "x" : 1317, "y" : 710 } } }, { "edgeId" : 5109, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 308, "y" : 846 }, "to" : { "x" : 453, "y" : 1199 } }, { "from" : { "x" : 453, "y" : 1199 }, "to" : { "x" : 1711, "y" : 1222 } }, { "from" : { "x" : 1711, "y" : 1222 }, "to" : { "x" : 1706, "y" : 620 } }, { "from" : { "x" : 1706, "y" : 620 }, "to" : { "x" : 1577, "y" : 514 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1574, "y" : 517 }, "b" : { "x" : 1580, "y" : 511 }, "c" : { "x" : 1577, "y" : 514 }, "type" : "STOP", "centre" : { "x" : 1577, "y" : 514 } } }, { "edgeId" : 1499, "type" : "INPUT", "segments" : [ { "from" : { "x" : 271, "y" : 833 }, "to" : { "x" : 217, "y" : 835 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 2415, "reactomeId" : 9844521, "displayName" : "NuRD:ZNF423:EBF2,EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, UCP1 gene, (CIDEA gene, DIO2 gene)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1005, "y" : 1070 }, "minX" : 959, "maxX" : 1051, "minY" : 1000, "maxY" : 1140, "prop" : { "x" : 959, "y" : 1000, "width" : 92, "height" : 140 }, "textPosition" : { "x" : 959, "y" : 997 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 5469, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1072, "reactomeId" : 9844404, "displayName" : "EBF2:Blnc1 lncRNA:HNRNPU", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 675, "y" : 357 }, "minX" : 613, "maxX" : 744, "minY" : 333, "maxY" : 376, "prop" : { "x" : 613, "y" : 339, "width" : 125, "height" : 37 }, "textPosition" : { "x" : 622, "y" : 341 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 738, "y" : 339 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 738, "y" : 339 } } }, "connectors" : [ { "edgeId" : 1068, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 4978, "reactomeId" : 9844472, "displayName" : "COX7A1 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1360, "y" : 285 }, "minX" : 1318, "maxX" : 1410, "minY" : 257, "maxY" : 311, "prop" : { "x" : 1318, "y" : 259, "width" : 85, "height" : 52 }, "textPosition" : { "x" : 1330, "y" : 286 }, "connectors" : [ { "edgeId" : 4977, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1410, "y" : 257 }, "b" : { "x" : 1403, "y" : 261 }, "c" : { "x" : 1410, "y" : 265 }, "type" : "ARROW", "centre" : { "x" : 1410, "y" : 265 } } }, { "id" : 818, "reactomeId" : 166394, "displayName" : "UCP1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1752, "y" : 228 }, "minX" : 1733, "maxX" : 1778, "minY" : 211, "maxY" : 240, "prop" : { "x" : 1733, "y" : 217, "width" : 39, "height" : 23 }, "textPosition" : { "x" : 1736, "y" : 211 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1772, "y" : 217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1772, "y" : 217 } } }, "connectors" : [ { "edgeId" : 3070, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 4979, "reactomeId" : 5336152, "displayName" : "COX7A1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1761, "y" : 270 }, "minX" : 1730, "maxX" : 1798, "minY" : 252, "maxY" : 283, "prop" : { "x" : 1730, "y" : 258, "width" : 62, "height" : 25 }, "textPosition" : { "x" : 1733, "y" : 260 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1792, "y" : 258 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1792, "y" : 258 } } }, "connectors" : [ { "edgeId" : 4977, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 4531, "reactomeId" : 9844801, "displayName" : "EBF2, EBF2:Blnc1 lncRNA:HNRNPU, Activated PPARG:RXRA:PPARA gene", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 779, "y" : 837 }, "minX" : 699, "maxX" : 983, "minY" : 743, "maxY" : 872, "prop" : { "x" : 699, "y" : 802, "width" : 161, "height" : 70 }, "textPosition" : { "x" : 704, "y" : 805 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 3037, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 856, "y" : 796 }, "to" : { "x" : 983, "y" : 744 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 978, "y" : 750 }, "b" : { "x" : 983, "y" : 744 }, "c" : { "x" : 975, "y" : 743 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 975, "y" : 743 } } } ] }, { "id" : 4339, "reactomeId" : 9844791, "displayName" : "EBF2, EBF2:Blnc1 lncRNA:HNRNPU, Activated PPARG:RXRA:PRDM16 gene", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 491, "y" : 595 }, "minX" : 200, "maxX" : 560, "minY" : 418, "maxY" : 627, "prop" : { "x" : 423, "y" : 563, "width" : 137, "height" : 64 }, "textPosition" : { "x" : 426, "y" : 563 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 2840, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 438, "y" : 557 }, "to" : { "x" : 200, "y" : 418 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 208, "y" : 418 }, "b" : { "x" : 200, "y" : 418 }, "c" : { "x" : 204, "y" : 425 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 204, "y" : 425 } } } ] }, { "id" : 758, "reactomeId" : 9843798, "displayName" : "UCP1 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 422, "y" : 210 }, "minX" : 389, "maxX" : 462, "minY" : 182, "maxY" : 236, "prop" : { "x" : 389, "y" : 184, "width" : 66, "height" : 52 }, "textPosition" : { "x" : 399, "y" : 211 }, "connectors" : [ { "edgeId" : 3070, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 462, "y" : 182 }, "b" : { "x" : 455, "y" : 186 }, "c" : { "x" : 462, "y" : 190 }, "type" : "ARROW", "centre" : { "x" : 462, "y" : 190 } } }, { "id" : 5110, "reactomeId" : 5641216, "displayName" : "ELOVL3 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1518, "y" : 606 }, "minX" : 1480, "maxX" : 1564, "minY" : 578, "maxY" : 632, "prop" : { "x" : 1480, "y" : 580, "width" : 77, "height" : 52 }, "textPosition" : { "x" : 1490, "y" : 607 }, "connectors" : [ { "edgeId" : 5109, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1564, "y" : 578 }, "b" : { "x" : 1557, "y" : 582 }, "c" : { "x" : 1564, "y" : 586 }, "type" : "ARROW", "centre" : { "x" : 1564, "y" : 586 } } }, { "id" : 5111, "reactomeId" : 548785, "displayName" : "ELOVL3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1763, "y" : 549 }, "minX" : 1737, "maxX" : 1796, "minY" : 532, "maxY" : 561, "prop" : { "x" : 1737, "y" : 538, "width" : 53, "height" : 23 }, "textPosition" : { "x" : 1737, "y" : 539 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1790, "y" : 538 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1790, "y" : 538 } } }, "connectors" : [ { "edgeId" : 5109, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 3071, "reactomeId" : 9844534, "displayName" : "NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1235, "y" : 505 }, "minX" : 778, "maxX" : 1307, "minY" : 261, "maxY" : 531, "prop" : { "x" : 1169, "y" : 480, "width" : 132, "height" : 51 }, "textPosition" : { "x" : 1175, "y" : 468 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1301, "y" : 480 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1301, "y" : 480 } } }, "connectors" : [ { "edgeId" : 3070, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1186, "y" : 477 }, "to" : { "x" : 780, "y" : 265 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 778, "y" : 269 }, "b" : { "x" : 782, "y" : 261 }, "c" : { "x" : 780, "y" : 265 }, "type" : "STOP", "centre" : { "x" : 780, "y" : 265 } } } ] } ], "edges" : [ { "id" : 5440, "reactomeId" : 9844440, "displayName" : "PPARG binds EBF2-bound gene loci", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1102, "y" : 696 }, "minX" : 1079, "maxX" : 1143, "minY" : 676, "maxY" : 798, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1079, "y" : 676 }, "to" : { "x" : 1102, "y" : 696 } }, { "from" : { "x" : 1102, "y" : 696 }, "to" : { "x" : 1143, "y" : 798 } } ], "endShape" : { "a" : { "x" : 1137, "y" : 793 }, "b" : { "x" : 1143, "y" : 798 }, "c" : { "x" : 1144, "y" : 790 }, "type" : "ARROW", "centre" : { "x" : 1144, "y" : 790 } }, "reactionShape" : { "a" : { "x" : 1096, "y" : 690 }, "b" : { "x" : 1108, "y" : 702 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1102, "y" : 696 } }, "inputs" : [ { "id" : 5441, "points" : [ { "x" : 1111, "y" : 640 } ], "stoichiometry" : 5 }, { "id" : 5442, "points" : [ { "x" : 1140, "y" : 674 } ], "stoichiometry" : 5 }, { "id" : 5443, "points" : [ { "x" : 583, "y" : 482 } ], "stoichiometry" : 10 }, { "id" : 5445, "points" : [ { "x" : 900, "y" : 669 } ] }, { "id" : 5451, "points" : [ { "x" : 1005, "y" : 612 } ], "stoichiometry" : 5 } ], "outputs" : [ { "id" : 3842 } ] }, { "id" : 3489, "reactomeId" : 9844598, "displayName" : "DIO2 gene transcription is stimulated by EBF2 and repressed by ZNF423", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1454, "y" : 856 }, "minX" : 1444, "maxX" : 1740, "minY" : 730, "maxY" : 862, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1444, "y" : 730 }, "to" : { "x" : 1454, "y" : 856 } }, { "from" : { "x" : 1454, "y" : 856 }, "to" : { "x" : 1740, "y" : 859 } } ], "endShape" : { "a" : { "x" : 1733, "y" : 863 }, "b" : { "x" : 1740, "y" : 859 }, "c" : { "x" : 1733, "y" : 855 }, "type" : "ARROW", "centre" : { "x" : 1733, "y" : 855 } }, "reactionShape" : { "a" : { "x" : 1448, "y" : 850 }, "b" : { "x" : 1460, "y" : 862 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1454, "y" : 856 } }, "inputs" : [ { "id" : 3490 } ], "outputs" : [ { "id" : 5482 } ], "inhibitors" : [ { "id" : 1455, "points" : [ { "x" : 306, "y" : 818 }, { "x" : 340, "y" : 678 }, { "x" : 474, "y" : 684 }, { "x" : 603, "y" : 891 }, { "x" : 1330, "y" : 1027 } ] }, { "id" : 2414, "points" : [ { "x" : 868, "y" : 1161 }, { "x" : 1300, "y" : 1186 } ] } ], "activators" : [ { "id" : 1758, "points" : [ { "x" : 717, "y" : 415 }, { "x" : 869, "y" : 370 }, { "x" : 1486, "y" : 446 } ] } ] }, { "id" : 5413, "reactomeId" : 9844366, "displayName" : "EBF2 binds target gene loci", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 714, "y" : 509 }, "minX" : 698, "maxX" : 722, "minY" : 482, "maxY" : 542, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 722, "y" : 482 }, "to" : { "x" : 714, "y" : 509 } }, { "from" : { "x" : 714, "y" : 509 }, "to" : { "x" : 698, "y" : 542 } } ], "endShape" : { "a" : { "x" : 697, "y" : 534 }, "b" : { "x" : 698, "y" : 542 }, "c" : { "x" : 705, "y" : 538 }, "type" : "ARROW", "centre" : { "x" : 705, "y" : 538 } }, "reactionShape" : { "a" : { "x" : 708, "y" : 503 }, "b" : { "x" : 720, "y" : 515 }, "s" : "", "type" : "BOX", "empty" : true, "centre" : { "x" : 714, "y" : 509 } }, "inputs" : [ { "id" : 1758, "points" : [ { "x" : 679, "y" : 456 } ], "stoichiometry" : 8 }, { "id" : 5414, "points" : [ { "x" : 762, "y" : 478 } ] } ], "outputs" : [ { "id" : 2093 } ] }, { "id" : 5319, "reactomeId" : 9844375, "displayName" : "ZNF423 binds EBF2 at EBF2-target gene loci", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 432, "y" : 948 }, "minX" : 384, "maxX" : 493, "minY" : 904, "maxY" : 966, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 384, "y" : 904 }, "to" : { "x" : 432, "y" : 948 } }, { "from" : { "x" : 432, "y" : 948 }, "to" : { "x" : 493, "y" : 966 } } ], "endShape" : { "a" : { "x" : 485, "y" : 968 }, "b" : { "x" : 493, "y" : 966 }, "c" : { "x" : 487, "y" : 960 }, "type" : "ARROW", "centre" : { "x" : 487, "y" : 960 } }, "reactionShape" : { "a" : { "x" : 426, "y" : 942 }, "b" : { "x" : 438, "y" : 954 }, "s" : "", "type" : "BOX", "empty" : true, "centre" : { "x" : 432, "y" : 948 } }, "inputs" : [ { "id" : 5320, "points" : [ { "x" : 402, "y" : 851 } ] }, { "id" : 1455, "points" : [ { "x" : 316, "y" : 846 } ], "stoichiometry" : 6 } ], "outputs" : [ { "id" : 2270 } ], "inhibitors" : [ { "id" : 1501, "points" : [ { "x" : 345, "y" : 963 } ] } ] }, { "id" : 5228, "reactomeId" : 9844822, "displayName" : "PPARGC1A gene expression is stimulated by EBF2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 292, "y" : 339 }, "minX" : 286, "maxX" : 313, "minY" : 229, "maxY" : 377, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 294, "y" : 229 }, "to" : { "x" : 292, "y" : 339 } }, { "from" : { "x" : 292, "y" : 339 }, "to" : { "x" : 313, "y" : 377 } } ], "endShape" : { "a" : { "x" : 306, "y" : 373 }, "b" : { "x" : 313, "y" : 377 }, "c" : { "x" : 313, "y" : 369 }, "type" : "ARROW", "centre" : { "x" : 313, "y" : 369 } }, "reactionShape" : { "a" : { "x" : 286, "y" : 333 }, "b" : { "x" : 298, "y" : 345 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 292, "y" : 339 } }, "inputs" : [ { "id" : 964 } ], "outputs" : [ { "id" : 1067 } ], "activators" : [ { "id" : 5229, "points" : [ { "x" : 518, "y" : 329 } ] }, { "id" : 1758, "points" : [ { "x" : 639, "y" : 456 }, { "x" : 592, "y" : 505 }, { "x" : 357, "y" : 495 }, { "x" : 251, "y" : 389 } ] } ] }, { "id" : 1068, "reactomeId" : 9844360, "displayName" : "EBF2 binds Blnc1 lncRNA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 580, "y" : 389 }, "minX" : 552, "maxX" : 620, "minY" : 379, "maxY" : 397, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 552, "y" : 397 }, "to" : { "x" : 580, "y" : 389 } }, { "from" : { "x" : 580, "y" : 389 }, "to" : { "x" : 620, "y" : 379 } } ], "endShape" : { "a" : { "x" : 614, "y" : 385 }, "b" : { "x" : 620, "y" : 379 }, "c" : { "x" : 612, "y" : 377 }, "type" : "ARROW", "centre" : { "x" : 612, "y" : 377 } }, "reactionShape" : { "c" : { "x" : 580, "y" : 389 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 580, "y" : 389 } }, "inputs" : [ { "id" : 1069, "points" : [ { "x" : 489, "y" : 370 } ] }, { "id" : 1070, "points" : [ { "x" : 503, "y" : 397 } ] }, { "id" : 1071, "points" : [ { "x" : 390, "y" : 444 } ] } ], "outputs" : [ { "id" : 1072 } ] }, { "id" : 5230, "reactomeId" : 9844600, "displayName" : "CIDEA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1318, "y" : 701 }, "minX" : 1312, "maxX" : 1623, "minY" : 636, "maxY" : 861, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 1400, "y" : 861 }, "to" : { "x" : 1318, "y" : 701 } }, { "from" : { "x" : 1318, "y" : 701 }, "to" : { "x" : 1623, "y" : 636 } } ], "endShape" : { "a" : { "x" : 1617, "y" : 641 }, "b" : { "x" : 1623, "y" : 636 }, "c" : { "x" : 1615, "y" : 634 }, "type" : "ARROW", "centre" : { "x" : 1615, "y" : 634 } }, "reactionShape" : { "a" : { "x" : 1312, "y" : 695 }, "b" : { "x" : 1324, "y" : 707 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 1318, "y" : 701 } }, "inputs" : [ { "id" : 3342 } ], "outputs" : [ { "id" : 3343 } ], "inhibitors" : [ { "id" : 1455, "points" : [ { "x" : 309, "y" : 846 }, { "x" : 472, "y" : 1187 }, { "x" : 1274, "y" : 1200 } ] }, { "id" : 2414, "points" : [ { "x" : 868, "y" : 1158 }, { "x" : 1260, "y" : 1151 } ] } ], "activators" : [ { "id" : 5229, "points" : [ { "x" : 594, "y" : 329 }, { "x" : 1306, "y" : 369 } ] }, { "id" : 1758, "points" : [ { "x" : 717, "y" : 417 }, { "x" : 869, "y" : 379 }, { "x" : 1009, "y" : 404 } ] } ] }, { "id" : 4977, "reactomeId" : 9844820, "displayName" : "COX7A1 gene expression is stimulated by EBF2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1512, "y" : 418 }, "minX" : 1412, "maxX" : 1739, "minY" : 261, "maxY" : 424, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1412, "y" : 261 }, "to" : { "x" : 1512, "y" : 418 } }, { "from" : { "x" : 1512, "y" : 418 }, "to" : { "x" : 1739, "y" : 286 } } ], "endShape" : { "a" : { "x" : 1735, "y" : 293 }, "b" : { "x" : 1739, "y" : 286 }, "c" : { "x" : 1731, "y" : 286 }, "type" : "ARROW", "centre" : { "x" : 1731, "y" : 286 } }, "reactionShape" : { "a" : { "x" : 1506, "y" : 412 }, "b" : { "x" : 1518, "y" : 424 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1512, "y" : 418 } }, "inputs" : [ { "id" : 4978 } ], "outputs" : [ { "id" : 4979 } ], "activators" : [ { "id" : 1758, "points" : [ { "x" : 701, "y" : 407 }, { "x" : 859, "y" : 350 } ] } ] }, { "id" : 5109, "reactomeId" : 9844818, "displayName" : "ELOVL3 gene expression is stimulated by EBF2 and negatively regulated by ZNF423", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1570, "y" : 508 }, "minX" : 1564, "maxX" : 1734, "minY" : 502, "maxY" : 582, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1566, "y" : 582 }, "to" : { "x" : 1570, "y" : 508 } }, { "from" : { "x" : 1570, "y" : 508 }, "to" : { "x" : 1734, "y" : 543 } } ], "endShape" : { "a" : { "x" : 1726, "y" : 545 }, "b" : { "x" : 1734, "y" : 543 }, "c" : { "x" : 1728, "y" : 538 }, "type" : "ARROW", "centre" : { "x" : 1728, "y" : 538 } }, "reactionShape" : { "a" : { "x" : 1564, "y" : 502 }, "b" : { "x" : 1576, "y" : 514 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1570, "y" : 508 } }, "inputs" : [ { "id" : 5110 } ], "outputs" : [ { "id" : 5111 } ], "inhibitors" : [ { "id" : 1455, "points" : [ { "x" : 308, "y" : 846 }, { "x" : 453, "y" : 1199 }, { "x" : 1711, "y" : 1222 }, { "x" : 1706, "y" : 620 } ] } ], "activators" : [ { "id" : 1758, "points" : [ { "x" : 708, "y" : 407 }, { "x" : 854, "y" : 362 }, { "x" : 1489, "y" : 433 } ] } ] }, { "id" : 2840, "reactomeId" : 9844415, "displayName" : "PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 192, "y" : 413 }, "minX" : 186, "maxX" : 359, "minY" : 179, "maxY" : 563, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 359, "y" : 563 }, "to" : { "x" : 192, "y" : 413 } }, { "from" : { "x" : 192, "y" : 413 }, "to" : { "x" : 192, "y" : 179 } } ], "endShape" : { "a" : { "x" : 196, "y" : 186 }, "b" : { "x" : 192, "y" : 179 }, "c" : { "x" : 188, "y" : 186 }, "type" : "ARROW", "centre" : { "x" : 188, "y" : 186 } }, "reactionShape" : { "a" : { "x" : 186, "y" : 407 }, "b" : { "x" : 198, "y" : 419 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 192, "y" : 413 } }, "inputs" : [ { "id" : 1641 } ], "outputs" : [ { "id" : 681 } ], "inhibitors" : [ { "id" : 2841, "points" : [ { "x" : 222, "y" : 631 } ] } ], "activators" : [ { "id" : 4339, "points" : [ { "x" : 438, "y" : 557 } ] } ] }, { "id" : 1499, "reactomeId" : 9844425, "displayName" : "SMAD1:SMAD4 trimer binds ZNF423", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 220, "y" : 894 }, "minX" : 215, "maxX" : 259, "minY" : 835, "maxY" : 954, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 217, "y" : 835 }, "to" : { "x" : 220, "y" : 894 } }, { "from" : { "x" : 220, "y" : 894 }, "to" : { "x" : 259, "y" : 954 } } ], "endShape" : { "a" : { "x" : 252, "y" : 950 }, "b" : { "x" : 259, "y" : 954 }, "c" : { "x" : 259, "y" : 946 }, "type" : "ARROW", "centre" : { "x" : 259, "y" : 946 } }, "reactionShape" : { "c" : { "x" : 220, "y" : 894 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 220, "y" : 894 } }, "inputs" : [ { "id" : 1500, "points" : [ { "x" : 216, "y" : 812 } ] }, { "id" : 1455, "points" : [ { "x" : 271, "y" : 833 } ] } ], "outputs" : [ { "id" : 1501 } ], "activators" : [ { "id" : 1502, "points" : [ { "x" : 81, "y" : 895 } ] } ] }, { "id" : 5469, "reactomeId" : 9844438, "displayName" : "ZNF423 recruits NuRD to EBF2 target genes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 906, "y" : 1061 }, "minX" : 830, "maxX" : 953, "minY" : 1056, "maxY" : 1066, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 830, "y" : 1057 }, "to" : { "x" : 906, "y" : 1061 } }, { "from" : { "x" : 906, "y" : 1061 }, "to" : { "x" : 953, "y" : 1065 } } ], "endShape" : { "a" : { "x" : 946, "y" : 1068 }, "b" : { "x" : 953, "y" : 1065 }, "c" : { "x" : 946, "y" : 1060 }, "type" : "ARROW", "centre" : { "x" : 946, "y" : 1060 } }, "reactionShape" : { "a" : { "x" : 900, "y" : 1055 }, "b" : { "x" : 912, "y" : 1067 }, "s" : "", "type" : "BOX", "empty" : true, "centre" : { "x" : 906, "y" : 1061 } }, "inputs" : [ { "id" : 2414, "points" : [ { "x" : 817, "y" : 1145 } ], "stoichiometry" : 4 }, { "id" : 5470, "points" : [ { "x" : 768, "y" : 1022 } ] } ], "outputs" : [ { "id" : 2415 } ] }, { "id" : 3037, "reactomeId" : 9844536, "displayName" : "PPARA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 991, "y" : 741 }, "minX" : 899, "maxX" : 1048, "minY" : 735, "maxY" : 747, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 899, "y" : 739 }, "to" : { "x" : 991, "y" : 741 } }, { "from" : { "x" : 991, "y" : 741 }, "to" : { "x" : 1048, "y" : 736 } } ], "endShape" : { "a" : { "x" : 1041, "y" : 741 }, "b" : { "x" : 1048, "y" : 736 }, "c" : { "x" : 1041, "y" : 733 }, "type" : "ARROW", "centre" : { "x" : 1041, "y" : 733 } }, "reactionShape" : { "a" : { "x" : 985, "y" : 735 }, "b" : { "x" : 997, "y" : 747 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 991, "y" : 741 } }, "inputs" : [ { "id" : 3038 } ], "outputs" : [ { "id" : 3039 } ], "inhibitors" : [ { "id" : 3040, "points" : [ { "x" : 990, "y" : 769 } ] } ], "activators" : [ { "id" : 4531, "points" : [ { "x" : 856, "y" : 796 } ] } ] }, { "id" : 3070, "reactomeId" : 9844549, "displayName" : "UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 772, "y" : 261 }, "minX" : 464, "maxX" : 1730, "minY" : 186, "maxY" : 267, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 464, "y" : 186 }, "to" : { "x" : 772, "y" : 261 } }, { "from" : { "x" : 772, "y" : 261 }, "to" : { "x" : 1730, "y" : 228 } } ], "endShape" : { "a" : { "x" : 1723, "y" : 232 }, "b" : { "x" : 1730, "y" : 228 }, "c" : { "x" : 1723, "y" : 224 }, "type" : "ARROW", "centre" : { "x" : 1723, "y" : 224 } }, "reactionShape" : { "a" : { "x" : 766, "y" : 255 }, "b" : { "x" : 778, "y" : 267 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 772, "y" : 261 } }, "inputs" : [ { "id" : 758 } ], "outputs" : [ { "id" : 818 } ], "inhibitors" : [ { "id" : 3071, "points" : [ { "x" : 1186, "y" : 477 } ] } ], "activators" : [ { "id" : 4816, "points" : [ { "x" : 989, "y" : 289 } ] } ] } ], "compartments" : [ { "id" : 848, "reactomeId" : 17927, "displayName" : "mitochondrial intermembrane space", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1803, "y" : 218 }, "minX" : 1712, "maxX" : 1895, "minY" : 53, "maxY" : 383, "prop" : { "x" : 1712, "y" : 53, "width" : 183, "height" : 330 }, "textPosition" : { "x" : 1730, "y" : 317 }, "insets" : { "x" : 1721, "y" : 63, "width" : 165, "height" : 305 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 847 ] }, { "id" : 5094, "reactomeId" : 12045, "displayName" : "endoplasmic reticulum membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1845, "y" : 583 }, "minX" : 1733, "maxX" : 1958, "minY" : 541, "maxY" : 626, "prop" : { "x" : 1733, "y" : 541, "width" : 225, "height" : 85 }, "textPosition" : { "x" : 1736, "y" : 581 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 5111 ] }, { "id" : 620, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1156, "y" : 656 }, "minX" : 96, "maxX" : 2216, "minY" : 0, "maxY" : 1312, "prop" : { "x" : 96, "y" : 0, "width" : 2120, "height" : 1312 }, "textPosition" : { "x" : 112, "y" : 1246 }, "insets" : { "x" : 109, "y" : 10, "width" : 2087, "height" : 1284 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 621, 848, 3343, 5094, 5482 ] }, { "id" : 621, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 871, "y" : 641 }, "minX" : 143, "maxX" : 1599, "minY" : 40, "maxY" : 1242, "prop" : { "x" : 143, "y" : 40, "width" : 1456, "height" : 1202 }, "textPosition" : { "x" : 162, "y" : 1148 }, "insets" : { "x" : 154, "y" : 50, "width" : 1433, "height" : 1176 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 681, 758, 964, 1067, 1068, 1070, 1071, 1072, 1069, 1455, 1499, 1500, 1501, 1758, 1759, 1760, 2093, 1641, 2270, 2414, 2415, 2840, 2841, 2842, 3037, 3038, 3039, 3040, 3041, 3070, 3071, 3072, 3342, 3489, 3490, 3842, 4341, 4342, 4339, 4531, 4533, 4534, 4818, 4819, 4977, 4978, 4816, 5110, 5109, 5228, 5229, 5230, 5319, 5320, 5321, 5322, 5324, 5325, 5413, 5414, 5415, 5416, 5417, 5418, 5419, 5420, 5421, 5422, 5440, 5441, 5442, 5443, 5444, 5445, 5446, 5447, 5448, 5449, 5450, 5451, 5469, 5471, 5470 ] }, { "id" : 847, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1806, "y" : 200 }, "minX" : 1741, "maxX" : 1872, "minY" : 74, "maxY" : 326, "prop" : { "x" : 1741, "y" : 74, "width" : 131, "height" : 252 }, "textPosition" : { "x" : 1754, "y" : 176 }, "insets" : { "x" : 1751, "y" : 84, "width" : 113, "height" : 233 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 818, 4979 ] } ], "notes" : [ ], "links" : [ { "id" : 3072, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1128, "y" : 764 }, "minX" : 1033, "maxX" : 1224, "minY" : 534, "maxY" : 994, "segments" : [ { "from" : { "x" : 1224, "y" : 534 }, "to" : { "x" : 1033, "y" : 994 } } ], "reactionShape" : { "a" : { "x" : 1122, "y" : 758 }, "b" : { "x" : 1134, "y" : 770 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1128, "y" : 764 } }, "inputs" : [ { "id" : 3071 } ], "outputs" : [ { "id" : 2415 } ] }, { "id" : 5444, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 401, "y" : 423 }, "minX" : 349, "maxX" : 453, "minY" : 406, "maxY" : 441, "segments" : [ { "from" : { "x" : 349, "y" : 406 }, "to" : { "x" : 453, "y" : 441 } } ], "reactionShape" : { "a" : { "x" : 395, "y" : 417 }, "b" : { "x" : 407, "y" : 429 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 401, "y" : 423 } }, "inputs" : [ { "id" : 1067 } ], "outputs" : [ { "id" : 5443 } ] }, { "id" : 5446, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 618, "y" : 727 }, "minX" : 483, "maxX" : 754, "minY" : 686, "maxY" : 768, "segments" : [ { "from" : { "x" : 754, "y" : 686 }, "to" : { "x" : 483, "y" : 768 } } ], "reactionShape" : { "a" : { "x" : 612, "y" : 721 }, "b" : { "x" : 624, "y" : 733 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 618, "y" : 727 } }, "inputs" : [ { "id" : 5445 } ], "outputs" : [ { "id" : 5320 } ] }, { "id" : 5447, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 801, "y" : 758 }, "minX" : 789, "maxX" : 813, "minY" : 720, "maxY" : 796, "segments" : [ { "from" : { "x" : 813, "y" : 720 }, "to" : { "x" : 789, "y" : 796 } } ], "reactionShape" : { "a" : { "x" : 795, "y" : 752 }, "b" : { "x" : 807, "y" : 764 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 801, "y" : 758 } }, "inputs" : [ { "id" : 5445 } ], "outputs" : [ { "id" : 4531 } ] }, { "id" : 5448, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 945, "y" : 478 }, "minX" : 856, "maxX" : 1034, "minY" : 341, "maxY" : 615, "segments" : [ { "from" : { "x" : 856, "y" : 615 }, "to" : { "x" : 1034, "y" : 341 } } ], "reactionShape" : { "a" : { "x" : 939, "y" : 472 }, "b" : { "x" : 951, "y" : 484 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 945, "y" : 478 } }, "inputs" : [ { "id" : 5445 } ], "outputs" : [ { "id" : 4816 } ] }, { "id" : 5321, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 588, "y" : 809 }, "minX" : 483, "maxX" : 693, "minY" : 793, "maxY" : 825, "segments" : [ { "from" : { "x" : 483, "y" : 793 }, "to" : { "x" : 693, "y" : 825 } } ], "reactionShape" : { "a" : { "x" : 582, "y" : 803 }, "b" : { "x" : 594, "y" : 815 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 588, "y" : 809 } }, "inputs" : [ { "id" : 5320 } ], "outputs" : [ { "id" : 4531 } ] }, { "id" : 5449, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 742, "y" : 645 }, "minX" : 730, "maxX" : 754, "minY" : 639, "maxY" : 651, "segments" : [ { "from" : { "x" : 754, "y" : 649 }, "to" : { "x" : 730, "y" : 641 } } ], "reactionShape" : { "a" : { "x" : 736, "y" : 639 }, "b" : { "x" : 748, "y" : 651 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 742, "y" : 645 } }, "inputs" : [ { "id" : 5445 } ], "outputs" : [ { "id" : 2093 } ] }, { "id" : 5322, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 746, "y" : 542 }, "minX" : 483, "maxX" : 1009, "minY" : 341, "maxY" : 743, "segments" : [ { "from" : { "x" : 483, "y" : 743 }, "to" : { "x" : 1009, "y" : 341 } } ], "reactionShape" : { "a" : { "x" : 740, "y" : 536 }, "b" : { "x" : 752, "y" : 548 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 746, "y" : 542 } }, "inputs" : [ { "id" : 5320 } ], "outputs" : [ { "id" : 4816 } ] }, { "id" : 5450, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 660, "y" : 630 }, "minX" : 566, "maxX" : 754, "minY" : 609, "maxY" : 652, "segments" : [ { "from" : { "x" : 754, "y" : 652 }, "to" : { "x" : 566, "y" : 609 } } ], "reactionShape" : { "a" : { "x" : 654, "y" : 624 }, "b" : { "x" : 666, "y" : 636 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 660, "y" : 630 } }, "inputs" : [ { "id" : 5445 } ], "outputs" : [ { "id" : 4339 } ] }, { "id" : 5324, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 544, "y" : 706 }, "minX" : 483, "maxX" : 605, "minY" : 664, "maxY" : 748, "segments" : [ { "from" : { "x" : 483, "y" : 748 }, "to" : { "x" : 605, "y" : 664 } } ], "reactionShape" : { "a" : { "x" : 538, "y" : 700 }, "b" : { "x" : 550, "y" : 712 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 544, "y" : 706 } }, "inputs" : [ { "id" : 5320 } ], "outputs" : [ { "id" : 2093 } ] }, { "id" : 5325, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 460, "y" : 676 }, "minX" : 443, "maxX" : 478, "minY" : 633, "maxY" : 719, "segments" : [ { "from" : { "x" : 443, "y" : 719 }, "to" : { "x" : 478, "y" : 633 } } ], "reactionShape" : { "a" : { "x" : 454, "y" : 670 }, "b" : { "x" : 466, "y" : 682 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 460, "y" : 676 } }, "inputs" : [ { "id" : 5320 } ], "outputs" : [ { "id" : 4339 } ] }, { "id" : 4818, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 872, "y" : 461 }, "minX" : 730, "maxX" : 1014, "minY" : 341, "maxY" : 581, "segments" : [ { "from" : { "x" : 1014, "y" : 341 }, "to" : { "x" : 730, "y" : 581 } } ], "reactionShape" : { "a" : { "x" : 866, "y" : 455 }, "b" : { "x" : 878, "y" : 467 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 872, "y" : 461 } }, "inputs" : [ { "id" : 4816 } ], "outputs" : [ { "id" : 2093 } ] }, { "id" : 4819, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1111, "y" : 569 }, "minX" : 1065, "maxX" : 1157, "minY" : 341, "maxY" : 798, "segments" : [ { "from" : { "x" : 1065, "y" : 341 }, "to" : { "x" : 1157, "y" : 798 } } ], "reactionShape" : { "a" : { "x" : 1105, "y" : 563 }, "b" : { "x" : 1117, "y" : 575 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1111, "y" : 569 } }, "inputs" : [ { "id" : 4816 } ], "outputs" : [ { "id" : 3842 } ] }, { "id" : 2842, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 520, "y" : 657 }, "minX" : 291, "maxX" : 543, "minY" : 651, "maxY" : 903, "segments" : [ { "from" : { "x" : 291, "y" : 662 }, "to" : { "x" : 520, "y" : 657 } }, { "from" : { "x" : 520, "y" : 657 }, "to" : { "x" : 543, "y" : 903 } } ], "reactionShape" : { "a" : { "x" : 514, "y" : 651 }, "b" : { "x" : 526, "y" : 663 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 520, "y" : 657 } }, "inputs" : [ { "id" : 2841 } ], "outputs" : [ { "id" : 2270 } ] }, { "id" : 1759, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 492, "y" : 441 }, "minX" : 390, "maxX" : 594, "minY" : 434, "maxY" : 448, "segments" : [ { "from" : { "x" : 390, "y" : 448 }, "to" : { "x" : 594, "y" : 434 } } ], "reactionShape" : { "a" : { "x" : 486, "y" : 435 }, "b" : { "x" : 498, "y" : 447 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 492, "y" : 441 } }, "inputs" : [ { "id" : 1071 } ], "outputs" : [ { "id" : 1758 } ] }, { "id" : 5471, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 618, "y" : 983 }, "minX" : 607, "maxX" : 630, "minY" : 977, "maxY" : 989, "segments" : [ { "from" : { "x" : 630, "y" : 984 }, "to" : { "x" : 607, "y" : 982 } } ], "reactionShape" : { "a" : { "x" : 612, "y" : 977 }, "b" : { "x" : 624, "y" : 989 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 618, "y" : 983 } }, "inputs" : [ { "id" : 5470 } ], "outputs" : [ { "id" : 2270 } ] }, { "id" : 1760, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 664, "y" : 393 }, "minX" : 658, "maxX" : 670, "minY" : 379, "maxY" : 407, "segments" : [ { "from" : { "x" : 669, "y" : 379 }, "to" : { "x" : 659, "y" : 407 } } ], "reactionShape" : { "a" : { "x" : 658, "y" : 387 }, "b" : { "x" : 670, "y" : 399 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 664, "y" : 393 } }, "inputs" : [ { "id" : 1072 } ], "outputs" : [ { "id" : 1758 } ] }, { "id" : 3041, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 995, "y" : 917 }, "minX" : 989, "maxX" : 1001, "minY" : 840, "maxY" : 994, "segments" : [ { "from" : { "x" : 991, "y" : 840 }, "to" : { "x" : 1000, "y" : 994 } } ], "reactionShape" : { "a" : { "x" : 989, "y" : 911 }, "b" : { "x" : 1001, "y" : 923 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 995, "y" : 917 } }, "inputs" : [ { "id" : 3040 } ], "outputs" : [ { "id" : 2415 } ] }, { "id" : 5415, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 560, "y" : 524 }, "minX" : 359, "maxX" : 762, "minY" : 486, "maxY" : 563, "segments" : [ { "from" : { "x" : 359, "y" : 563 }, "to" : { "x" : 762, "y" : 486 } } ], "reactionShape" : { "a" : { "x" : 554, "y" : 518 }, "b" : { "x" : 566, "y" : 530 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 560, "y" : 524 } }, "inputs" : [ { "id" : 1641 } ], "outputs" : [ { "id" : 5414 } ] }, { "id" : 5416, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 528, "y" : 336 }, "minX" : 294, "maxX" : 762, "minY" : 229, "maxY" : 443, "segments" : [ { "from" : { "x" : 294, "y" : 229 }, "to" : { "x" : 762, "y" : 443 } } ], "reactionShape" : { "a" : { "x" : 522, "y" : 330 }, "b" : { "x" : 534, "y" : 342 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 528, "y" : 336 } }, "inputs" : [ { "id" : 964 } ], "outputs" : [ { "id" : 5414 } ] }, { "id" : 5417, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 872, "y" : 633 }, "minX" : 846, "maxX" : 899, "minY" : 527, "maxY" : 739, "segments" : [ { "from" : { "x" : 899, "y" : 739 }, "to" : { "x" : 846, "y" : 527 } } ], "reactionShape" : { "a" : { "x" : 866, "y" : 627 }, "b" : { "x" : 878, "y" : 639 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 872, "y" : 633 } }, "inputs" : [ { "id" : 3038 } ], "outputs" : [ { "id" : 5414 } ] }, { "id" : 5418, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 619, "y" : 304 }, "minX" : 464, "maxX" : 775, "minY" : 186, "maxY" : 422, "segments" : [ { "from" : { "x" : 464, "y" : 186 }, "to" : { "x" : 775, "y" : 422 } } ], "reactionShape" : { "a" : { "x" : 613, "y" : 298 }, "b" : { "x" : 625, "y" : 310 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 619, "y" : 304 } }, "inputs" : [ { "id" : 758 } ], "outputs" : [ { "id" : 5414 } ] }, { "id" : 5419, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1154, "y" : 690 }, "minX" : 908, "maxX" : 1400, "minY" : 519, "maxY" : 861, "segments" : [ { "from" : { "x" : 1400, "y" : 861 }, "to" : { "x" : 908, "y" : 519 } } ], "reactionShape" : { "a" : { "x" : 1148, "y" : 684 }, "b" : { "x" : 1160, "y" : 696 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1154, "y" : 690 } }, "inputs" : [ { "id" : 3342 } ], "outputs" : [ { "id" : 5414 } ] }, { "id" : 5420, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1237, "y" : 532 }, "minX" : 908, "maxX" : 1566, "minY" : 483, "maxY" : 582, "segments" : [ { "from" : { "x" : 1566, "y" : 582 }, "to" : { "x" : 908, "y" : 483 } } ], "reactionShape" : { "a" : { "x" : 1231, "y" : 526 }, "b" : { "x" : 1243, "y" : 538 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1237, "y" : 532 } }, "inputs" : [ { "id" : 5110 } ], "outputs" : [ { "id" : 5414 } ] }, { "id" : 5421, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1176, "y" : 616 }, "minX" : 908, "maxX" : 1444, "minY" : 502, "maxY" : 730, "segments" : [ { "from" : { "x" : 1444, "y" : 730 }, "to" : { "x" : 908, "y" : 502 } } ], "reactionShape" : { "a" : { "x" : 1170, "y" : 610 }, "b" : { "x" : 1182, "y" : 622 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1176, "y" : 616 } }, "inputs" : [ { "id" : 3490 } ], "outputs" : [ { "id" : 5414 } ] }, { "id" : 5422, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1160, "y" : 355 }, "minX" : 908, "maxX" : 1412, "minY" : 261, "maxY" : 449, "segments" : [ { "from" : { "x" : 1412, "y" : 261 }, "to" : { "x" : 908, "y" : 449 } } ], "reactionShape" : { "a" : { "x" : 1154, "y" : 349 }, "b" : { "x" : 1166, "y" : 361 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1160, "y" : 355 } }, "inputs" : [ { "id" : 4978 } ], "outputs" : [ { "id" : 5414 } ] }, { "id" : 4341, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 585, "y" : 611 }, "minX" : 566, "maxX" : 605, "minY" : 605, "maxY" : 617, "segments" : [ { "from" : { "x" : 566, "y" : 607 }, "to" : { "x" : 605, "y" : 616 } } ], "reactionShape" : { "a" : { "x" : 579, "y" : 605 }, "b" : { "x" : 591, "y" : 617 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 585, "y" : 611 } }, "inputs" : [ { "id" : 4339 } ], "outputs" : [ { "id" : 2093 } ] }, { "id" : 4533, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 735, "y" : 755 }, "minX" : 711, "maxX" : 759, "minY" : 715, "maxY" : 796, "segments" : [ { "from" : { "x" : 759, "y" : 796 }, "to" : { "x" : 711, "y" : 715 } } ], "reactionShape" : { "a" : { "x" : 729, "y" : 749 }, "b" : { "x" : 741, "y" : 761 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 735, "y" : 755 } }, "inputs" : [ { "id" : 4531 } ], "outputs" : [ { "id" : 2093 } ] }, { "id" : 4342, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 841, "y" : 743 }, "minX" : 566, "maxX" : 1117, "minY" : 624, "maxY" : 862, "segments" : [ { "from" : { "x" : 566, "y" : 624 }, "to" : { "x" : 1117, "y" : 862 } } ], "reactionShape" : { "a" : { "x" : 835, "y" : 737 }, "b" : { "x" : 847, "y" : 749 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 841, "y" : 743 } }, "inputs" : [ { "id" : 4339 } ], "outputs" : [ { "id" : 3842 } ] }, { "id" : 4534, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 991, "y" : 861 }, "minX" : 866, "maxX" : 1117, "minY" : 846, "maxY" : 877, "segments" : [ { "from" : { "x" : 866, "y" : 846 }, "to" : { "x" : 1117, "y" : 877 } } ], "reactionShape" : { "a" : { "x" : 985, "y" : 855 }, "b" : { "x" : 997, "y" : 867 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 991, "y" : 861 } }, "inputs" : [ { "id" : 4531 } ], "outputs" : [ { "id" : 3842 } ] } ], "shadows" : [ { "id" : 5483, "reactomeId" : 9844594, "displayName" : "Transcriptional regulation of brown and beige adipocyte differentiation by EBF2", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 922, "y" : 662 }, "minX" : -10, "maxX" : 1855, "minY" : 143, "maxY" : 1181, "prop" : { "x" : -10, "y" : 143, "width" : 1865, "height" : 1038 }, "points" : [ { "x" : -10, "y" : 143 }, { "x" : 1855, "y" : 143 }, { "x" : 1855, "y" : 1181 }, { "x" : -10, "y" : 1181 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 2216, "minY" : 0, "maxY" : 1312, "disease" : false }