{
  "dbId" : 9823739,
  "stableId" : "R-HSA-9823739",
  "displayName" : "Formation of the anterior neural plate",
  "nodes" : [ {
    "id" : 3,
    "reactomeId" : 2888991,
    "displayName" : "SOX2 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 385,
      "y" : 111
    },
    "minX" : 325,
    "maxX" : 542,
    "minY" : 83,
    "maxY" : 189,
    "prop" : {
      "x" : 325,
      "y" : 85,
      "width" : 121,
      "height" : 52
    },
    "textPosition" : {
      "x" : 347,
      "y" : 112
    },
    "connectors" : [ {
      "edgeId" : 2,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 13,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 455,
          "y" : 87
        },
        "to" : {
          "x" : 542,
          "y" : 189
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 453,
        "y" : 83
      },
      "b" : {
        "x" : 446,
        "y" : 87
      },
      "c" : {
        "x" : 453,
        "y" : 91
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 453,
        "y" : 91
      }
    }
  }, {
    "id" : 4,
    "reactomeId" : 452271,
    "displayName" : "SOX2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 973,
      "y" : 151
    },
    "minX" : 939,
    "maxX" : 1013,
    "minY" : 129,
    "maxY" : 193,
    "prop" : {
      "x" : 939,
      "y" : 135,
      "width" : 68,
      "height" : 32
    },
    "textPosition" : {
      "x" : 953,
      "y" : 140
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1007,
          "y" : 135
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1007,
          "y" : 135
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 45,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 973,
          "y" : 170
        },
        "to" : {
          "x" : 974,
          "y" : 193
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 5,
    "reactomeId" : 9833000,
    "displayName" : "POU5F1:SOX2 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 778,
      "y" : 68
    },
    "minX" : 668,
    "maxX" : 826,
    "minY" : 42,
    "maxY" : 94,
    "prop" : {
      "x" : 736,
      "y" : 48,
      "width" : 84,
      "height" : 41
    },
    "textPosition" : {
      "x" : 740,
      "y" : 54
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 820,
          "y" : 48
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 820,
          "y" : 48
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 733,
          "y" : 77
        },
        "to" : {
          "x" : 668,
          "y" : 92
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 674,
          "y" : 87
        },
        "b" : {
          "x" : 668,
          "y" : 92
        },
        "c" : {
          "x" : 676,
          "y" : 94
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 676,
          "y" : 94
        }
      }
    } ]
  }, {
    "id" : 6,
    "reactomeId" : 9832833,
    "displayName" : "POU3F1:SOX2 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 614,
      "y" : 141
    },
    "minX" : 571,
    "maxX" : 664,
    "minY" : 100,
    "maxY" : 161,
    "prop" : {
      "x" : 571,
      "y" : 121,
      "width" : 87,
      "height" : 40
    },
    "textPosition" : {
      "x" : 576,
      "y" : 126
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 658,
          "y" : 121
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 658,
          "y" : 121
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 633,
          "y" : 118
        },
        "to" : {
          "x" : 652,
          "y" : 100
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 650,
          "y" : 108
        },
        "b" : {
          "x" : 652,
          "y" : 100
        },
        "c" : {
          "x" : 644,
          "y" : 102
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 644,
          "y" : 102
        }
      }
    }, {
      "edgeId" : 13,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 8,
    "reactomeId" : 9613637,
    "displayName" : "POU3F1 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 127,
      "y" : 210
    },
    "minX" : 82,
    "maxX" : 179,
    "minY" : 182,
    "maxY" : 236,
    "prop" : {
      "x" : 82,
      "y" : 184,
      "width" : 90,
      "height" : 52
    },
    "textPosition" : {
      "x" : 96,
      "y" : 211
    },
    "connectors" : [ {
      "edgeId" : 7,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 179,
        "y" : 182
      },
      "b" : {
        "x" : 172,
        "y" : 186
      },
      "c" : {
        "x" : 179,
        "y" : 190
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 179,
        "y" : 190
      }
    }
  }, {
    "id" : 9,
    "reactomeId" : 9613634,
    "displayName" : "POU3F1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 386,
      "y" : 284
    },
    "minX" : 187,
    "maxX" : 881,
    "minY" : 189,
    "maxY" : 808,
    "prop" : {
      "x" : 350,
      "y" : 269,
      "width" : 72,
      "height" : 31
    },
    "textPosition" : {
      "x" : 357,
      "y" : 274
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 422,
          "y" : 269
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 422,
          "y" : 269
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 387,
          "y" : 303
        },
        "to" : {
          "x" : 435,
          "y" : 728
        }
      }, {
        "from" : {
          "x" : 435,
          "y" : 728
        },
        "to" : {
          "x" : 581,
          "y" : 808
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 573,
          "y" : 808
        },
        "b" : {
          "x" : 581,
          "y" : 808
        },
        "c" : {
          "x" : 577,
          "y" : 801
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 577,
          "y" : 801
        }
      }
    }, {
      "edgeId" : 7,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 40,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 347,
          "y" : 297
        },
        "to" : {
          "x" : 187,
          "y" : 359
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 13,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 411,
          "y" : 266
        },
        "to" : {
          "x" : 542,
          "y" : 189
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 46,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 425,
          "y" : 282
        },
        "to" : {
          "x" : 881,
          "y" : 268
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 874,
          "y" : 272
        },
        "b" : {
          "x" : 881,
          "y" : 268
        },
        "c" : {
          "x" : 874,
          "y" : 264
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 874,
          "y" : 264
        }
      }
    }, {
      "edgeId" : 50,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 382,
          "y" : 303
        },
        "to" : {
          "x" : 299,
          "y" : 707
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 18,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 408,
          "y" : 303
        },
        "to" : {
          "x" : 497,
          "y" : 362
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 23,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 425,
          "y" : 297
        },
        "to" : {
          "x" : 700,
          "y" : 401
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 10,
    "reactomeId" : 9833221,
    "displayName" : "NANOG:POU3F1 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 174,
      "y" : 139
    },
    "minX" : 100,
    "maxX" : 255,
    "minY" : 118,
    "maxY" : 182,
    "prop" : {
      "x" : 100,
      "y" : 124,
      "width" : 149,
      "height" : 30
    },
    "textPosition" : {
      "x" : 104,
      "y" : 133
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 249,
          "y" : 124
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 249,
          "y" : 124
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 7,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 204,
          "y" : 157
        },
        "to" : {
          "x" : 252,
          "y" : 178
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 250,
          "y" : 182
        },
        "b" : {
          "x" : 254,
          "y" : 174
        },
        "c" : {
          "x" : 252,
          "y" : 178
        },
        "type" : "STOP",
        "centre" : {
          "x" : 252,
          "y" : 178
        }
      }
    } ]
  }, {
    "id" : 19,
    "reactomeId" : 9832799,
    "displayName" : "ZNF521 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 464,
      "y" : 445
    },
    "minX" : 427,
    "maxX" : 510,
    "minY" : 362,
    "maxY" : 471,
    "prop" : {
      "x" : 427,
      "y" : 419,
      "width" : 74,
      "height" : 52
    },
    "textPosition" : {
      "x" : 433,
      "y" : 446
    },
    "connectors" : [ {
      "edgeId" : 18,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 510,
          "y" : 421
        },
        "to" : {
          "x" : 497,
          "y" : 362
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 508,
        "y" : 417
      },
      "b" : {
        "x" : 501,
        "y" : 421
      },
      "c" : {
        "x" : 508,
        "y" : 425
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 508,
        "y" : 425
      }
    }
  }, {
    "id" : 20,
    "reactomeId" : 9832836,
    "displayName" : "POU3F1:ZNF521 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 585,
      "y" : 428
    },
    "minX" : 536,
    "maxX" : 640,
    "minY" : 403,
    "maxY" : 479,
    "prop" : {
      "x" : 536,
      "y" : 409,
      "width" : 98,
      "height" : 39
    },
    "textPosition" : {
      "x" : 538,
      "y" : 413
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 634,
          "y" : 409
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 634,
          "y" : 409
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 18,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 576,
          "y" : 451
        },
        "to" : {
          "x" : 562,
          "y" : 479
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 562,
          "y" : 471
        },
        "b" : {
          "x" : 562,
          "y" : 479
        },
        "c" : {
          "x" : 569,
          "y" : 475
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 569,
          "y" : 475
        }
      }
    } ]
  }, {
    "id" : 22,
    "reactomeId" : 3222324,
    "displayName" : "ZNF521",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 605,
      "y" : 550
    },
    "minX" : 566,
    "maxX" : 700,
    "minY" : 401,
    "maxY" : 598,
    "prop" : {
      "x" : 566,
      "y" : 536,
      "width" : 78,
      "height" : 29
    },
    "textPosition" : {
      "x" : 576,
      "y" : 540
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 644,
          "y" : 536
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 644,
          "y" : 536
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 47,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 605,
          "y" : 568
        },
        "to" : {
          "x" : 608,
          "y" : 598
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 21,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 23,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 614,
          "y" : 533
        },
        "to" : {
          "x" : 700,
          "y" : 401
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 24,
    "reactomeId" : 9832796,
    "displayName" : "PAX6 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 696,
      "y" : 519
    },
    "minX" : 664,
    "maxX" : 737,
    "minY" : 401,
    "maxY" : 545,
    "prop" : {
      "x" : 664,
      "y" : 493,
      "width" : 64,
      "height" : 52
    },
    "textPosition" : {
      "x" : 674,
      "y" : 520
    },
    "connectors" : [ {
      "edgeId" : 23,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 737,
          "y" : 495
        },
        "to" : {
          "x" : 700,
          "y" : 401
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 26,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 735,
        "y" : 491
      },
      "b" : {
        "x" : 728,
        "y" : 495
      },
      "c" : {
        "x" : 735,
        "y" : 499
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 735,
        "y" : 499
      }
    }
  }, {
    "id" : 25,
    "reactomeId" : 9832854,
    "displayName" : "POU3F1:ZNF521:PAX6 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 813,
      "y" : 562
    },
    "minX" : 749,
    "maxX" : 878,
    "minY" : 534,
    "maxY" : 601,
    "prop" : {
      "x" : 754,
      "y" : 540,
      "width" : 118,
      "height" : 45
    },
    "textPosition" : {
      "x" : 756,
      "y" : 550
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 872,
          "y" : 540
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 872,
          "y" : 540
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 23,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 26,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 774,
          "y" : 588
        },
        "to" : {
          "x" : 749,
          "y" : 600
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 754,
          "y" : 593
        },
        "b" : {
          "x" : 749,
          "y" : 600
        },
        "c" : {
          "x" : 757,
          "y" : 601
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 757,
          "y" : 601
        }
      }
    } ]
  }, {
    "id" : 27,
    "reactomeId" : 3009044,
    "displayName" : "PAX6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 744,
      "y" : 668
    },
    "minX" : 708,
    "maxX" : 786,
    "minY" : 648,
    "maxY" : 683,
    "prop" : {
      "x" : 708,
      "y" : 654,
      "width" : 72,
      "height" : 29
    },
    "textPosition" : {
      "x" : 724,
      "y" : 658
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 780,
          "y" : 654
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 780,
          "y" : 654
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 31,
    "reactomeId" : 9793598,
    "displayName" : "ZEB2 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 842,
      "y" : 192
    },
    "minX" : 803,
    "maxX" : 974,
    "minY" : 164,
    "maxY" : 218,
    "prop" : {
      "x" : 803,
      "y" : 166,
      "width" : 78,
      "height" : 52
    },
    "textPosition" : {
      "x" : 803,
      "y" : 193
    },
    "connectors" : [ {
      "edgeId" : 45,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 890,
          "y" : 168
        },
        "to" : {
          "x" : 974,
          "y" : 193
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 46,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 888,
        "y" : 164
      },
      "b" : {
        "x" : 881,
        "y" : 168
      },
      "c" : {
        "x" : 888,
        "y" : 172
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 888,
        "y" : 172
      }
    }
  }, {
    "id" : 32,
    "reactomeId" : 9833048,
    "displayName" : "SOX2:ZEB2 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 974,
      "y" : 274
    },
    "minX" : 899,
    "maxX" : 1040,
    "minY" : 254,
    "maxY" : 289,
    "prop" : {
      "x" : 915,
      "y" : 260,
      "width" : 119,
      "height" : 29
    },
    "textPosition" : {
      "x" : 918,
      "y" : 268
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1034,
          "y" : 260
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1034,
          "y" : 260
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 45,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 46,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 912,
          "y" : 269
        },
        "to" : {
          "x" : 899,
          "y" : 268
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 906,
          "y" : 265
        },
        "b" : {
          "x" : 899,
          "y" : 268
        },
        "c" : {
          "x" : 906,
          "y" : 273
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 906,
          "y" : 273
        }
      }
    } ]
  }, {
    "id" : 34,
    "reactomeId" : 3108222,
    "displayName" : "ZEB2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 895,
      "y" : 334
    },
    "minX" : 598,
    "maxX" : 925,
    "minY" : 312,
    "maxY" : 811,
    "prop" : {
      "x" : 871,
      "y" : 318,
      "width" : 48,
      "height" : 33
    },
    "textPosition" : {
      "x" : 874,
      "y" : 324
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 919,
          "y" : 318
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 919,
          "y" : 318
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 895,
          "y" : 354
        },
        "to" : {
          "x" : 896,
          "y" : 720
        }
      }, {
        "from" : {
          "x" : 896,
          "y" : 720
        },
        "to" : {
          "x" : 598,
          "y" : 809
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 603,
          "y" : 803
        },
        "b" : {
          "x" : 598,
          "y" : 809
        },
        "c" : {
          "x" : 606,
          "y" : 811
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 606,
          "y" : 811
        }
      }
    }, {
      "edgeId" : 46,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 36,
    "reactomeId" : 9832909,
    "displayName" : "SOX1 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 539,
      "y" : 635
    },
    "minX" : 499,
    "maxX" : 608,
    "minY" : 598,
    "maxY" : 661,
    "prop" : {
      "x" : 499,
      "y" : 609,
      "width" : 80,
      "height" : 52
    },
    "textPosition" : {
      "x" : 501,
      "y" : 636
    },
    "connectors" : [ {
      "edgeId" : 38,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 47,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 588,
          "y" : 611
        },
        "to" : {
          "x" : 608,
          "y" : 598
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 586,
        "y" : 607
      },
      "b" : {
        "x" : 579,
        "y" : 611
      },
      "c" : {
        "x" : 586,
        "y" : 615
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 586,
        "y" : 615
      }
    }
  }, {
    "id" : 37,
    "reactomeId" : 9832904,
    "displayName" : "ZNF521:SOX1 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 675,
      "y" : 738
    },
    "minX" : 596,
    "maxX" : 749,
    "minY" : 718,
    "maxY" : 806,
    "prop" : {
      "x" : 608,
      "y" : 724,
      "width" : 135,
      "height" : 29
    },
    "textPosition" : {
      "x" : 611,
      "y" : 732
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 743,
          "y" : 724
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 743,
          "y" : 724
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 658,
          "y" : 756
        },
        "to" : {
          "x" : 596,
          "y" : 806
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 599,
          "y" : 799
        },
        "b" : {
          "x" : 596,
          "y" : 806
        },
        "c" : {
          "x" : 604,
          "y" : 805
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 604,
          "y" : 805
        }
      }
    }, {
      "edgeId" : 47,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39,
    "reactomeId" : 9832899,
    "displayName" : "SOX1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 588,
      "y" : 902
    },
    "minX" : 567,
    "maxX" : 615,
    "minY" : 885,
    "maxY" : 914,
    "prop" : {
      "x" : 567,
      "y" : 891,
      "width" : 42,
      "height" : 23
    },
    "textPosition" : {
      "x" : 568,
      "y" : 892
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 609,
          "y" : 891
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 609,
          "y" : 891
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 38,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 41,
    "reactomeId" : 9832930,
    "displayName" : "ZIC2 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 66,
      "y" : 340
    },
    "minX" : 29,
    "maxX" : 187,
    "minY" : 312,
    "maxY" : 366,
    "prop" : {
      "x" : 29,
      "y" : 314,
      "width" : 75,
      "height" : 52
    },
    "textPosition" : {
      "x" : 30,
      "y" : 341
    },
    "connectors" : [ {
      "edgeId" : 40,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 113,
          "y" : 316
        },
        "to" : {
          "x" : 187,
          "y" : 359
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 48,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 111,
        "y" : 312
      },
      "b" : {
        "x" : 104,
        "y" : 316
      },
      "c" : {
        "x" : 111,
        "y" : 320
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 111,
        "y" : 320
      }
    }
  }, {
    "id" : 42,
    "reactomeId" : 9832929,
    "displayName" : "POU3F1:ZIC2 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 187,
      "y" : 457
    },
    "minX" : 122,
    "maxX" : 257,
    "minY" : 436,
    "maxY" : 513,
    "prop" : {
      "x" : 123,
      "y" : 442,
      "width" : 128,
      "height" : 31
    },
    "textPosition" : {
      "x" : 124,
      "y" : 452
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 251,
          "y" : 442
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 251,
          "y" : 442
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 40,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 48,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 169,
          "y" : 476
        },
        "to" : {
          "x" : 122,
          "y" : 513
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 125,
          "y" : 506
        },
        "b" : {
          "x" : 122,
          "y" : 513
        },
        "c" : {
          "x" : 130,
          "y" : 512
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 130,
          "y" : 512
        }
      }
    } ]
  }, {
    "id" : 49,
    "reactomeId" : 5216208,
    "displayName" : "ZIC2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 117,
      "y" : 601
    },
    "minX" : 87,
    "maxX" : 153,
    "minY" : 583,
    "maxY" : 614,
    "prop" : {
      "x" : 87,
      "y" : 589,
      "width" : 60,
      "height" : 25
    },
    "textPosition" : {
      "x" : 99,
      "y" : 591
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 147,
          "y" : 589
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 147,
          "y" : 589
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 48,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 51,
    "reactomeId" : 9832939,
    "displayName" : "OTX2 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 165,
      "y" : 658
    },
    "minX" : 131,
    "maxX" : 299,
    "minY" : 630,
    "maxY" : 707,
    "prop" : {
      "x" : 131,
      "y" : 632,
      "width" : 69,
      "height" : 52
    },
    "textPosition" : {
      "x" : 144,
      "y" : 659
    },
    "connectors" : [ {
      "edgeId" : 50,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 209,
          "y" : 634
        },
        "to" : {
          "x" : 299,
          "y" : 707
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 53,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 207,
        "y" : 630
      },
      "b" : {
        "x" : 200,
        "y" : 634
      },
      "c" : {
        "x" : 207,
        "y" : 638
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 207,
        "y" : 638
      }
    }
  }, {
    "id" : 52,
    "reactomeId" : 9832934,
    "displayName" : "POU3F1:OTX2 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 301,
      "y" : 785
    },
    "minX" : 230,
    "maxX" : 379,
    "minY" : 767,
    "maxY" : 850,
    "prop" : {
      "x" : 230,
      "y" : 773,
      "width" : 143,
      "height" : 25
    },
    "textPosition" : {
      "x" : 237,
      "y" : 777
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 373,
          "y" : 773
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 373,
          "y" : 773
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 53,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 300,
          "y" : 801
        },
        "to" : {
          "x" : 297,
          "y" : 850
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 293,
          "y" : 843
        },
        "b" : {
          "x" : 297,
          "y" : 850
        },
        "c" : {
          "x" : 301,
          "y" : 843
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 301,
          "y" : 843
        }
      }
    } ]
  }, {
    "id" : 54,
    "reactomeId" : 9832936,
    "displayName" : "OTX2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 297,
      "y" : 926
    },
    "minX" : 268,
    "maxX" : 332,
    "minY" : 904,
    "maxY" : 942,
    "prop" : {
      "x" : 268,
      "y" : 910,
      "width" : 58,
      "height" : 32
    },
    "textPosition" : {
      "x" : 277,
      "y" : 915
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 326,
          "y" : 910
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 326,
          "y" : 910
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 53,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 55,
    "reactomeId" : 9833054,
    "displayName" : "GBX2:OTX2 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 424,
      "y" : 837
    },
    "minX" : 305,
    "maxX" : 496,
    "minY" : 816,
    "maxY" : 861,
    "prop" : {
      "x" : 358,
      "y" : 822,
      "width" : 132,
      "height" : 31
    },
    "textPosition" : {
      "x" : 368,
      "y" : 832
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 490,
          "y" : 822
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 490,
          "y" : 822
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 53,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 355,
          "y" : 848
        },
        "to" : {
          "x" : 306,
          "y" : 857
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 305,
          "y" : 853
        },
        "b" : {
          "x" : 307,
          "y" : 861
        },
        "c" : {
          "x" : 306,
          "y" : 857
        },
        "type" : "STOP",
        "centre" : {
          "x" : 306,
          "y" : 857
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 2,
    "reactomeId" : 9832841,
    "displayName" : "Expression of SOX2 in anterior neural plate",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 659,
      "y" : 94
    },
    "minX" : 455,
    "maxX" : 936,
    "minY" : 87,
    "maxY" : 144,
    "reactionType" : "uncertain",
    "segments" : [ {
      "from" : {
        "x" : 455,
        "y" : 87
      },
      "to" : {
        "x" : 659,
        "y" : 94
      }
    }, {
      "from" : {
        "x" : 659,
        "y" : 94
      },
      "to" : {
        "x" : 936,
        "y" : 144
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 928,
        "y" : 147
      },
      "b" : {
        "x" : 936,
        "y" : 144
      },
      "c" : {
        "x" : 930,
        "y" : 139
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 930,
        "y" : 139
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 653,
        "y" : 88
      },
      "b" : {
        "x" : 665,
        "y" : 100
      },
      "s" : "?",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 659,
        "y" : 94
      }
    },
    "inputs" : [ {
      "id" : 3
    } ],
    "outputs" : [ {
      "id" : 4
    } ],
    "activators" : [ {
      "id" : 5,
      "points" : [ {
        "x" : 733,
        "y" : 77
      } ]
    }, {
      "id" : 6,
      "points" : [ {
        "x" : 633,
        "y" : 118
      } ]
    } ]
  }, {
    "id" : 38,
    "reactomeId" : 9832907,
    "displayName" : "Expression of SOX1 in neural plate",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 589,
      "y" : 812
    },
    "minX" : 583,
    "maxX" : 595,
    "minY" : 611,
    "maxY" : 888,
    "reactionType" : "uncertain",
    "segments" : [ {
      "from" : {
        "x" : 588,
        "y" : 611
      },
      "to" : {
        "x" : 589,
        "y" : 812
      }
    }, {
      "from" : {
        "x" : 589,
        "y" : 812
      },
      "to" : {
        "x" : 588,
        "y" : 888
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 584,
        "y" : 881
      },
      "b" : {
        "x" : 588,
        "y" : 888
      },
      "c" : {
        "x" : 592,
        "y" : 881
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 592,
        "y" : 881
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 583,
        "y" : 806
      },
      "b" : {
        "x" : 595,
        "y" : 818
      },
      "s" : "?",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 589,
        "y" : 812
      }
    },
    "inputs" : [ {
      "id" : 36
    } ],
    "outputs" : [ {
      "id" : 39
    } ],
    "activators" : [ {
      "id" : 9,
      "points" : [ {
        "x" : 387,
        "y" : 303
      }, {
        "x" : 435,
        "y" : 728
      } ]
    }, {
      "id" : 37,
      "points" : [ {
        "x" : 658,
        "y" : 756
      } ]
    }, {
      "id" : 34,
      "points" : [ {
        "x" : 895,
        "y" : 354
      }, {
        "x" : 896,
        "y" : 720
      } ]
    } ]
  }, {
    "id" : 7,
    "reactomeId" : 9832813,
    "displayName" : "Expression of POU3F1 in anterior neural plate",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 260,
      "y" : 182
    },
    "minX" : 181,
    "maxX" : 366,
    "minY" : 176,
    "maxY" : 266,
    "reactionType" : "uncertain",
    "segments" : [ {
      "from" : {
        "x" : 181,
        "y" : 186
      },
      "to" : {
        "x" : 260,
        "y" : 182
      }
    }, {
      "from" : {
        "x" : 260,
        "y" : 182
      },
      "to" : {
        "x" : 366,
        "y" : 266
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 358,
        "y" : 265
      },
      "b" : {
        "x" : 366,
        "y" : 266
      },
      "c" : {
        "x" : 363,
        "y" : 259
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 363,
        "y" : 259
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 254,
        "y" : 176
      },
      "b" : {
        "x" : 266,
        "y" : 188
      },
      "s" : "?",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 260,
        "y" : 182
      }
    },
    "inputs" : [ {
      "id" : 8
    } ],
    "outputs" : [ {
      "id" : 9
    } ],
    "inhibitors" : [ {
      "id" : 10,
      "points" : [ {
        "x" : 204,
        "y" : 157
      } ]
    } ]
  }, {
    "id" : 40,
    "reactomeId" : 9832943,
    "displayName" : "POU3F1 binds the ZIC2 gene",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 187,
      "y" : 389
    },
    "minX" : 181,
    "maxX" : 193,
    "minY" : 359,
    "maxY" : 439,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 187,
        "y" : 359
      },
      "to" : {
        "x" : 187,
        "y" : 389
      }
    }, {
      "from" : {
        "x" : 187,
        "y" : 389
      },
      "to" : {
        "x" : 187,
        "y" : 439
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 183,
        "y" : 432
      },
      "b" : {
        "x" : 187,
        "y" : 439
      },
      "c" : {
        "x" : 191,
        "y" : 432
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 191,
        "y" : 432
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 187,
        "y" : 389
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 187,
        "y" : 389
      }
    },
    "inputs" : [ {
      "id" : 9,
      "points" : [ {
        "x" : 347,
        "y" : 297
      } ]
    }, {
      "id" : 41,
      "points" : [ {
        "x" : 113,
        "y" : 316
      } ]
    } ],
    "outputs" : [ {
      "id" : 42
    } ]
  }, {
    "id" : 13,
    "reactomeId" : 9832824,
    "displayName" : "POU3F1 binds the SOX2 gene",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 564,
      "y" : 175
    },
    "minX" : 542,
    "maxX" : 584,
    "minY" : 164,
    "maxY" : 189,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 542,
        "y" : 189
      },
      "to" : {
        "x" : 564,
        "y" : 175
      }
    }, {
      "from" : {
        "x" : 564,
        "y" : 175
      },
      "to" : {
        "x" : 584,
        "y" : 164
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 580,
        "y" : 171
      },
      "b" : {
        "x" : 584,
        "y" : 164
      },
      "c" : {
        "x" : 576,
        "y" : 164
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 576,
        "y" : 164
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 564,
        "y" : 175
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 564,
        "y" : 175
      }
    },
    "inputs" : [ {
      "id" : 9,
      "points" : [ {
        "x" : 411,
        "y" : 266
      } ]
    }, {
      "id" : 3,
      "points" : [ {
        "x" : 455,
        "y" : 87
      } ]
    } ],
    "outputs" : [ {
      "id" : 6
    } ]
  }, {
    "id" : 45,
    "reactomeId" : 9833066,
    "displayName" : "SOX2 binds the ZEB2 gene",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 972,
      "y" : 226
    },
    "minX" : 966,
    "maxX" : 978,
    "minY" : 193,
    "maxY" : 257,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 974,
        "y" : 193
      },
      "to" : {
        "x" : 972,
        "y" : 226
      }
    }, {
      "from" : {
        "x" : 972,
        "y" : 226
      },
      "to" : {
        "x" : 973,
        "y" : 257
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 969,
        "y" : 250
      },
      "b" : {
        "x" : 973,
        "y" : 257
      },
      "c" : {
        "x" : 977,
        "y" : 250
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 977,
        "y" : 250
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 972,
        "y" : 226
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 972,
        "y" : 226
      }
    },
    "inputs" : [ {
      "id" : 4,
      "points" : [ {
        "x" : 973,
        "y" : 170
      } ]
    }, {
      "id" : 31,
      "points" : [ {
        "x" : 890,
        "y" : 168
      } ]
    } ],
    "outputs" : [ {
      "id" : 32
    } ]
  }, {
    "id" : 46,
    "reactomeId" : 9832845,
    "displayName" : "Expression of ZEB2 in neural plate",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 890,
      "y" : 268
    },
    "minX" : 884,
    "maxX" : 896,
    "minY" : 168,
    "maxY" : 315,
    "reactionType" : "uncertain",
    "segments" : [ {
      "from" : {
        "x" : 890,
        "y" : 168
      },
      "to" : {
        "x" : 890,
        "y" : 268
      }
    }, {
      "from" : {
        "x" : 890,
        "y" : 268
      },
      "to" : {
        "x" : 893,
        "y" : 315
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 889,
        "y" : 308
      },
      "b" : {
        "x" : 893,
        "y" : 315
      },
      "c" : {
        "x" : 897,
        "y" : 308
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 897,
        "y" : 308
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 884,
        "y" : 262
      },
      "b" : {
        "x" : 896,
        "y" : 274
      },
      "s" : "?",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 890,
        "y" : 268
      }
    },
    "inputs" : [ {
      "id" : 31
    } ],
    "outputs" : [ {
      "id" : 34
    } ],
    "activators" : [ {
      "id" : 9,
      "points" : [ {
        "x" : 425,
        "y" : 282
      } ]
    }, {
      "id" : 32,
      "points" : [ {
        "x" : 912,
        "y" : 269
      } ]
    } ]
  }, {
    "id" : 47,
    "reactomeId" : 9832908,
    "displayName" : "ZNF521 binds the SOX1 gene",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 608,
      "y" : 632
    },
    "minX" : 602,
    "maxX" : 665,
    "minY" : 598,
    "maxY" : 721,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 608,
        "y" : 598
      },
      "to" : {
        "x" : 608,
        "y" : 632
      }
    }, {
      "from" : {
        "x" : 608,
        "y" : 632
      },
      "to" : {
        "x" : 665,
        "y" : 721
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 658,
        "y" : 717
      },
      "b" : {
        "x" : 665,
        "y" : 721
      },
      "c" : {
        "x" : 665,
        "y" : 713
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 665,
        "y" : 713
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 608,
        "y" : 632
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 608,
        "y" : 632
      }
    },
    "inputs" : [ {
      "id" : 36,
      "points" : [ {
        "x" : 588,
        "y" : 611
      } ]
    }, {
      "id" : 22,
      "points" : [ {
        "x" : 605,
        "y" : 568
      } ]
    } ],
    "outputs" : [ {
      "id" : 37
    } ]
  }, {
    "id" : 48,
    "reactomeId" : 9832951,
    "displayName" : "Expression of ZIC2 in anterior neural plate",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 115,
      "y" : 519
    },
    "minX" : 109,
    "maxX" : 121,
    "minY" : 316,
    "maxY" : 586,
    "reactionType" : "uncertain",
    "segments" : [ {
      "from" : {
        "x" : 113,
        "y" : 316
      },
      "to" : {
        "x" : 115,
        "y" : 519
      }
    }, {
      "from" : {
        "x" : 115,
        "y" : 519
      },
      "to" : {
        "x" : 116,
        "y" : 586
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 112,
        "y" : 579
      },
      "b" : {
        "x" : 116,
        "y" : 586
      },
      "c" : {
        "x" : 120,
        "y" : 579
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 120,
        "y" : 579
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 109,
        "y" : 513
      },
      "b" : {
        "x" : 121,
        "y" : 525
      },
      "s" : "?",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 115,
        "y" : 519
      }
    },
    "inputs" : [ {
      "id" : 41
    } ],
    "outputs" : [ {
      "id" : 49
    } ],
    "activators" : [ {
      "id" : 42,
      "points" : [ {
        "x" : 169,
        "y" : 476
      } ]
    } ]
  }, {
    "id" : 50,
    "reactomeId" : 9832935,
    "displayName" : "POU3F1 binds the OTX2 gene",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 299,
      "y" : 713
    },
    "minX" : 293,
    "maxX" : 305,
    "minY" : 707,
    "maxY" : 770,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 299,
        "y" : 707
      },
      "to" : {
        "x" : 299,
        "y" : 713
      }
    }, {
      "from" : {
        "x" : 299,
        "y" : 713
      },
      "to" : {
        "x" : 300,
        "y" : 770
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 296,
        "y" : 763
      },
      "b" : {
        "x" : 300,
        "y" : 770
      },
      "c" : {
        "x" : 304,
        "y" : 763
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 304,
        "y" : 763
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 299,
        "y" : 713
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 299,
        "y" : 713
      }
    },
    "inputs" : [ {
      "id" : 9,
      "points" : [ {
        "x" : 382,
        "y" : 303
      } ]
    }, {
      "id" : 51,
      "points" : [ {
        "x" : 209,
        "y" : 634
      } ]
    } ],
    "outputs" : [ {
      "id" : 52
    } ]
  }, {
    "id" : 18,
    "reactomeId" : 9832844,
    "displayName" : "POU3F1 binds the ZNF521 gene",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 527,
      "y" : 381
    },
    "minX" : 497,
    "maxX" : 560,
    "minY" : 362,
    "maxY" : 406,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 497,
        "y" : 362
      },
      "to" : {
        "x" : 527,
        "y" : 381
      }
    }, {
      "from" : {
        "x" : 527,
        "y" : 381
      },
      "to" : {
        "x" : 560,
        "y" : 406
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 552,
        "y" : 405
      },
      "b" : {
        "x" : 560,
        "y" : 406
      },
      "c" : {
        "x" : 557,
        "y" : 399
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 557,
        "y" : 399
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 527,
        "y" : 381
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 527,
        "y" : 381
      }
    },
    "inputs" : [ {
      "id" : 9,
      "points" : [ {
        "x" : 408,
        "y" : 303
      } ]
    }, {
      "id" : 19,
      "points" : [ {
        "x" : 510,
        "y" : 421
      } ]
    } ],
    "outputs" : [ {
      "id" : 20
    } ]
  }, {
    "id" : 21,
    "reactomeId" : 9832834,
    "displayName" : "Expression of ZNF521 in anterior neural plate",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 558,
      "y" : 487
    },
    "minX" : 510,
    "maxX" : 594,
    "minY" : 421,
    "maxY" : 533,
    "reactionType" : "uncertain",
    "segments" : [ {
      "from" : {
        "x" : 510,
        "y" : 421
      },
      "to" : {
        "x" : 558,
        "y" : 487
      }
    }, {
      "from" : {
        "x" : 558,
        "y" : 487
      },
      "to" : {
        "x" : 594,
        "y" : 533
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 587,
        "y" : 530
      },
      "b" : {
        "x" : 594,
        "y" : 533
      },
      "c" : {
        "x" : 593,
        "y" : 525
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 593,
        "y" : 525
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 552,
        "y" : 481
      },
      "b" : {
        "x" : 564,
        "y" : 493
      },
      "s" : "?",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 558,
        "y" : 487
      }
    },
    "inputs" : [ {
      "id" : 19
    } ],
    "outputs" : [ {
      "id" : 22
    } ],
    "activators" : [ {
      "id" : 20,
      "points" : [ {
        "x" : 576,
        "y" : 451
      } ]
    } ]
  }, {
    "id" : 53,
    "reactomeId" : 9832938,
    "displayName" : "Expression of OTX2 in anterior neural plate",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 297,
      "y" : 859
    },
    "minX" : 209,
    "maxX" : 303,
    "minY" : 634,
    "maxY" : 907,
    "reactionType" : "uncertain",
    "segments" : [ {
      "from" : {
        "x" : 209,
        "y" : 634
      },
      "to" : {
        "x" : 211,
        "y" : 831
      }
    }, {
      "from" : {
        "x" : 211,
        "y" : 831
      },
      "to" : {
        "x" : 297,
        "y" : 859
      }
    }, {
      "from" : {
        "x" : 297,
        "y" : 859
      },
      "to" : {
        "x" : 297,
        "y" : 907
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 293,
        "y" : 900
      },
      "b" : {
        "x" : 297,
        "y" : 907
      },
      "c" : {
        "x" : 301,
        "y" : 900
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 301,
        "y" : 900
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 291,
        "y" : 853
      },
      "b" : {
        "x" : 303,
        "y" : 865
      },
      "s" : "?",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 297,
        "y" : 859
      }
    },
    "inputs" : [ {
      "id" : 51
    } ],
    "outputs" : [ {
      "id" : 54
    } ],
    "inhibitors" : [ {
      "id" : 55,
      "points" : [ {
        "x" : 355,
        "y" : 848
      } ]
    } ],
    "activators" : [ {
      "id" : 52,
      "points" : [ {
        "x" : 300,
        "y" : 801
      } ]
    } ]
  }, {
    "id" : 23,
    "reactomeId" : 9832823,
    "displayName" : "POU3F1 and ZNF521 bind the PAX6 gene",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 816,
      "y" : 496
    },
    "minX" : 700,
    "maxX" : 822,
    "minY" : 401,
    "maxY" : 537,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 700,
        "y" : 401
      },
      "to" : {
        "x" : 816,
        "y" : 496
      }
    }, {
      "from" : {
        "x" : 816,
        "y" : 496
      },
      "to" : {
        "x" : 814,
        "y" : 537
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 810,
        "y" : 530
      },
      "b" : {
        "x" : 814,
        "y" : 537
      },
      "c" : {
        "x" : 818,
        "y" : 530
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 818,
        "y" : 530
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 816,
        "y" : 496
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 816,
        "y" : 496
      }
    },
    "inputs" : [ {
      "id" : 22,
      "points" : [ {
        "x" : 614,
        "y" : 533
      } ]
    }, {
      "id" : 9,
      "points" : [ {
        "x" : 425,
        "y" : 297
      } ]
    }, {
      "id" : 24,
      "points" : [ {
        "x" : 737,
        "y" : 495
      } ]
    } ],
    "outputs" : [ {
      "id" : 25
    } ]
  }, {
    "id" : 26,
    "reactomeId" : 9832850,
    "displayName" : "Expression of PAX6 in anterior neural plate",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 741,
      "y" : 604
    },
    "minX" : 735,
    "maxX" : 747,
    "minY" : 495,
    "maxY" : 651,
    "reactionType" : "uncertain",
    "segments" : [ {
      "from" : {
        "x" : 737,
        "y" : 495
      },
      "to" : {
        "x" : 741,
        "y" : 604
      }
    }, {
      "from" : {
        "x" : 741,
        "y" : 604
      },
      "to" : {
        "x" : 743,
        "y" : 651
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 739,
        "y" : 644
      },
      "b" : {
        "x" : 743,
        "y" : 651
      },
      "c" : {
        "x" : 747,
        "y" : 644
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 747,
        "y" : 644
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 735,
        "y" : 598
      },
      "b" : {
        "x" : 747,
        "y" : 610
      },
      "s" : "?",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 741,
        "y" : 604
      }
    },
    "inputs" : [ {
      "id" : 24
    } ],
    "outputs" : [ {
      "id" : 27
    } ],
    "activators" : [ {
      "id" : 25,
      "points" : [ {
        "x" : 774,
        "y" : 588
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 1,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 535,
      "y" : 498
    },
    "minX" : 0,
    "maxX" : 1071,
    "minY" : 0,
    "maxY" : 996,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1071,
      "height" : 996
    },
    "textPosition" : {
      "x" : 25,
      "y" : 943
    },
    "insets" : {
      "x" : 8,
      "y" : 10,
      "width" : 1053,
      "height" : 971
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 2, 3, 4, 5, 6, 7, 8, 9, 10, 13, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 31, 32, 34, 36, 37, 38, 39, 45, 46, 47, 51, 50, 52, 53, 54, 55, 40, 41, 42, 48, 49 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1071,
  "minY" : 0,
  "maxY" : 996,
  "disease" : false
}