{ "dbId" : 9725370, "stableId" : "R-HSA-9725370", "displayName" : "Signaling by ALK fusions and activated point mutants", "forNormalDraw" : false, "nodes" : [ { "id" : 8, "reactomeId" : 201500, "displayName" : "PTN", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 174, "y" : 1715 }, "isFadeOut" : true, "minX" : 158, "maxX" : 227, "minY" : 1704, "maxY" : 1727, "prop" : { "x" : 158, "y" : 1704, "width" : 33, "height" : 23 }, "textPosition" : { "x" : 158, "y" : 1705 }, "connectors" : [ { "edgeId" : 7, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 194, "y" : 1716 }, "to" : { "x" : 227, "y" : 1721 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9, "reactomeId" : 201502, "displayName" : "ALK", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 148, "y" : 91 }, "isFadeOut" : true, "minX" : 76, "maxX" : 245, "minY" : 80, "maxY" : 1732, "prop" : { "x" : 133, "y" : 80, "width" : 31, "height" : 23 }, "textPosition" : { "x" : 134, "y" : 81 }, "connectors" : [ { "edgeId" : 7, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 147, "y" : 106 }, "to" : { "x" : 120, "y" : 468 } }, { "from" : { "x" : 120, "y" : 468 }, "to" : { "x" : 227, "y" : 1721 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 11, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 144, "y" : 106 }, "to" : { "x" : 76, "y" : 334 } }, { "from" : { "x" : 76, "y" : 334 }, "to" : { "x" : 102, "y" : 1558 } }, { "from" : { "x" : 102, "y" : 1558 }, "to" : { "x" : 141, "y" : 1732 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15513, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 167, "y" : 95 }, "to" : { "x" : 245, "y" : 122 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 200, "y" : 102 }, "b" : { "x" : 212, "y" : 114 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 206, "y" : 108 } } } }, { "edgeId" : 15283, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 10, "reactomeId" : 201520, "displayName" : "PTN:ALK", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 271, "y" : 1785 }, "isFadeOut" : true, "minX" : 242, "maxX" : 301, "minY" : 1774, "maxY" : 1978, "prop" : { "x" : 242, "y" : 1774, "width" : 59, "height" : 23 }, "textPosition" : { "x" : 243, "y" : 1776 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 7, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 27, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 271, "y" : 1800 }, "to" : { "x" : 278, "y" : 1918 } }, { "from" : { "x" : 278, "y" : 1918 }, "to" : { "x" : 277, "y" : 1978 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 16395, "reactomeId" : 9850892, "displayName" : "MAPK8,9", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1045, "y" : 2686 }, "minX" : 1014, "maxX" : 1076, "minY" : 2675, "maxY" : 2717, "prop" : { "x" : 1014, "y" : 2675, "width" : 62, "height" : 23 }, "textPosition" : { "x" : 1014, "y" : 2676 }, "connectors" : [ { "edgeId" : 16394, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1055, "y" : 2704 }, "to" : { "x" : 1072, "y" : 2717 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 16907, "reactomeId" : 9008901, "displayName" : "PTPN6 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1454, "y" : 2024 }, "minX" : 1414, "maxX" : 1556, "minY" : 1907, "maxY" : 2050, "prop" : { "x" : 1414, "y" : 1998, "width" : 80, "height" : 52 }, "textPosition" : { "x" : 1428, "y" : 2025 }, "connectors" : [ { "edgeId" : 15989, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1503, "y" : 2000 }, "to" : { "x" : 1556, "y" : 1907 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15997, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1501, "y" : 1996 }, "b" : { "x" : 1494, "y" : 2000 }, "c" : { "x" : 1501, "y" : 2004 }, "type" : "ARROW", "centre" : { "x" : 1501, "y" : 2004 } } }, { "id" : 12, "reactomeId" : 2160953, "displayName" : "MDK", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 104, "y" : 1713 }, "isFadeOut" : true, "minX" : 86, "maxX" : 141, "minY" : 1702, "maxY" : 1732, "prop" : { "x" : 86, "y" : 1702, "width" : 36, "height" : 23 }, "textPosition" : { "x" : 87, "y" : 1703 }, "connectors" : [ { "edgeId" : 11, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 125, "y" : 1722 }, "to" : { "x" : 141, "y" : 1732 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 15884, "reactomeId" : 9850864, "displayName" : "MIR21 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 2145, "y" : 1945 }, "minX" : 2106, "maxX" : 2193, "minY" : 1868, "maxY" : 1971, "prop" : { "x" : 2106, "y" : 1919, "width" : 78, "height" : 52 }, "textPosition" : { "x" : 2120, "y" : 1946 }, "connectors" : [ { "edgeId" : 15883, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2193, "y" : 1921 }, "to" : { "x" : 2186, "y" : 1868 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15890, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 2191, "y" : 1917 }, "b" : { "x" : 2184, "y" : 1921 }, "c" : { "x" : 2191, "y" : 1925 }, "type" : "ARROW", "centre" : { "x" : 2191, "y" : 1925 } } }, { "id" : 16396, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1032, "y" : 2757 }, "minX" : 1012, "maxX" : 1072, "minY" : 2717, "maxY" : 2773, "prop" : { "x" : 1012, "y" : 2742, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1016, "y" : 2747 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1047, "y" : 2747 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1047, "y" : 2747 } } }, "connectors" : [ { "edgeId" : 16394, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1047, "y" : 2739 }, "to" : { "x" : 1072, "y" : 2717 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1053, "y" : 2722 }, "b" : { "x" : 1065, "y" : 2734 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1059, "y" : 2728 } } }, "isDisease" : true } ] }, { "id" : 16908, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1345, "y" : 3176 }, "minX" : 1298, "maxX" : 1366, "minY" : 3160, "maxY" : 3211, "prop" : { "x" : 1325, "y" : 3161, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1329, "y" : 3166 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1360, "y" : 3166 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1360, "y" : 3166 } } }, "connectors" : [ { "edgeId" : 16366, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1322, "y" : 3190 }, "to" : { "x" : 1298, "y" : 3211 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1304, "y" : 3194 }, "b" : { "x" : 1316, "y" : 3206 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1310, "y" : 3200 } } }, "isDisease" : true } ] }, { "id" : 15885, "reactomeId" : 9850896, "displayName" : "MIR21 gene:AcK685-pY705,p-S727 STAT3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2547, "y" : 1836 }, "minX" : 2487, "maxX" : 2613, "minY" : 1805, "maxY" : 1885, "prop" : { "x" : 2487, "y" : 1811, "width" : 120, "height" : 51 }, "textPosition" : { "x" : 2490, "y" : 1799 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2607, "y" : 1811 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2607, "y" : 1811 } } }, "connectors" : [ { "edgeId" : 15883, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15890, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 2542, "y" : 1865 }, "to" : { "x" : 2539, "y" : 1884 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2535, "y" : 1883 }, "b" : { "x" : 2543, "y" : 1885 }, "c" : { "x" : 2539, "y" : 1884 }, "type" : "STOP", "centre" : { "x" : 2539, "y" : 1884 } }, "isDisease" : true } ] }, { "id" : 13, "reactomeId" : 9667909, "displayName" : "MDK:ALK", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 216, "y" : 1823 }, "isFadeOut" : true, "minX" : 144, "maxX" : 247, "minY" : 1812, "maxY" : 2023, "prop" : { "x" : 185, "y" : 1812, "width" : 62, "height" : 23 }, "textPosition" : { "x" : 186, "y" : 1814 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 11, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 29, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 208, "y" : 1838 }, "to" : { "x" : 144, "y" : 1935 } }, { "from" : { "x" : 144, "y" : 1935 }, "to" : { "x" : 206, "y" : 2023 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 16909, "reactomeId" : 1112559, "displayName" : "STAT1, STAT3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1260, "y" : 3174 }, "minX" : 1214, "maxX" : 1307, "minY" : 3163, "maxY" : 3211, "prop" : { "x" : 1214, "y" : 3163, "width" : 93, "height" : 23 }, "textPosition" : { "x" : 1214, "y" : 3164 }, "connectors" : [ { "edgeId" : 16366, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1271, "y" : 3192 }, "to" : { "x" : 1298, "y" : 3211 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 16398, "reactomeId" : 9850928, "displayName" : "p-T,Y MAPK8,9", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1277, "y" : 2918 }, "minX" : 1234, "maxX" : 1595, "minY" : 2803, "maxY" : 2934, "prop" : { "x" : 1234, "y" : 2903, "width" : 87, "height" : 31 }, "textPosition" : { "x" : 1234, "y" : 2901 }, "connectors" : [ { "edgeId" : 16419, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1327, "y" : 2916 }, "to" : { "x" : 1424, "y" : 2914 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1417, "y" : 2918 }, "b" : { "x" : 1424, "y" : 2914 }, "c" : { "x" : 1417, "y" : 2910 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1417, "y" : 2910 } }, "isDisease" : true }, { "edgeId" : 16682, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1291, "y" : 2897 }, "to" : { "x" : 1388, "y" : 2803 } }, { "from" : { "x" : 1388, "y" : 2803 }, "to" : { "x" : 1595, "y" : 2807 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 16452, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15891, "reactomeId" : 9850916, "displayName" : "miR21 RISC", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2842, "y" : 1896 }, "minX" : 2804, "maxX" : 2880, "minY" : 1823, "maxY" : 1908, "prop" : { "x" : 2804, "y" : 1885, "width" : 76, "height" : 23 }, "textPosition" : { "x" : 2817, "y" : 1879 }, "connectors" : [ { "edgeId" : 15890, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15912, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2845, "y" : 1879 }, "to" : { "x" : 2866, "y" : 1823 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14873, "reactomeId" : 9718460, "displayName" : "MYH9- and RNF213-ALK fusions", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1401, "y" : 940 }, "isDisease" : true, "minX" : 1337, "maxX" : 1466, "minY" : 922, "maxY" : 959, "prop" : { "x" : 1337, "y" : 922, "width" : 129, "height" : 37 }, "textPosition" : { "x" : 1359, "y" : 916 }, "connectors" : [ { "edgeId" : 14872, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14874, "reactomeId" : 9724089, "displayName" : "p-7Y MYH9- and RNF213-ALK fusions", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1582, "y" : 948 }, "isDisease" : true, "minX" : 1518, "maxX" : 1647, "minY" : 930, "maxY" : 967, "prop" : { "x" : 1518, "y" : 930, "width" : 129, "height" : 37 }, "textPosition" : { "x" : 1528, "y" : 924 }, "connectors" : [ { "edgeId" : 14872, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 28, "reactomeId" : 201496, "displayName" : "PTN:ALK dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 324, "y" : 2092 }, "isFadeOut" : true, "minX" : 276, "maxX" : 373, "minY" : 2081, "maxY" : 2104, "prop" : { "x" : 276, "y" : 2081, "width" : 97, "height" : 23 }, "textPosition" : { "x" : 276, "y" : 2083 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 27, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 30, "reactomeId" : 9699997, "displayName" : "MDK:ALK dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 226, "y" : 2121 }, "isFadeOut" : true, "minX" : 176, "maxX" : 276, "minY" : 2110, "maxY" : 2133, "prop" : { "x" : 176, "y" : 2110, "width" : 100, "height" : 23 }, "textPosition" : { "x" : 177, "y" : 2112 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 29, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 16421, "reactomeId" : 450237, "displayName" : "p-S63,S73-JUN", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1645, "y" : 2881 }, "minX" : 1433, "maxX" : 1728, "minY" : 2856, "maxY" : 2919, "prop" : { "x" : 1608, "y" : 2862, "width" : 75, "height" : 38 }, "innerProp" : { "x" : 1608, "y" : 2868, "width" : 75, "height" : 32 }, "textPosition" : { "x" : 1617, "y" : 2863 }, "nodeAttachments" : [ { "reactomeId" : 168361, "label" : "P", "description" : "O-phospho-L-serine at 63", "shape" : { "a" : { "x" : 1618, "y" : 2856 }, "b" : { "x" : 1630, "y" : 2868 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1624, "y" : 2862 } } }, { "reactomeId" : 450265, "label" : "P", "description" : "O-phospho-L-serine at 73", "shape" : { "a" : { "x" : 1634, "y" : 2856 }, "b" : { "x" : 1646, "y" : 2868 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1640, "y" : 2862 } } } ], "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1683, "y" : 2862 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1683, "y" : 2862 } } }, "connectors" : [ { "edgeId" : 16419, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1605, "y" : 2882 }, "to" : { "x" : 1433, "y" : 2891 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1598, "y" : 2886 }, "b" : { "x" : 1605, "y" : 2882 }, "c" : { "x" : 1598, "y" : 2878 }, "type" : "ARROW", "centre" : { "x" : 1598, "y" : 2878 } }, "isDisease" : true }, { "edgeId" : 16430, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1686, "y" : 2897 }, "to" : { "x" : 1726, "y" : 2915 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1724, "y" : 2919 }, "b" : { "x" : 1728, "y" : 2911 }, "c" : { "x" : 1726, "y" : 2915 }, "type" : "STOP", "centre" : { "x" : 1726, "y" : 2915 } }, "isDisease" : true } ] }, { "id" : 15910, "reactomeId" : 9850861, "displayName" : "DNMT1 mRNA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "RNA", "position" : { "x" : 2811, "y" : 1699 }, "minX" : 2749, "maxX" : 2874, "minY" : 1680, "maxY" : 1823, "prop" : { "x" : 2749, "y" : 1680, "width" : 125, "height" : 39 }, "textPosition" : { "x" : 2766, "y" : 1689 }, "connectors" : [ { "edgeId" : 15909, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15912, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2819, "y" : 1714 }, "to" : { "x" : 2866, "y" : 1823 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15925, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 16422, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1388, "y" : 2848 }, "minX" : 1369, "maxX" : 1433, "minY" : 2835, "maxY" : 2891, "prop" : { "x" : 1369, "y" : 2836, "width" : 38, "height" : 24 }, "textPosition" : { "x" : 1371, "y" : 2837 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1402, "y" : 2841 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1402, "y" : 2841 } } }, "connectors" : [ { "edgeId" : 16419, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1400, "y" : 2863 }, "to" : { "x" : 1433, "y" : 2891 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1410, "y" : 2871 }, "b" : { "x" : 1422, "y" : 2883 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1416, "y" : 2877 } } }, "endShape" : { "a" : { "x" : 1408, "y" : 2864 }, "b" : { "x" : 1400, "y" : 2863 }, "c" : { "x" : 1403, "y" : 2871 }, "type" : "ARROW", "centre" : { "x" : 1403, "y" : 2871 } }, "isDisease" : true } ] }, { "id" : 15911, "reactomeId" : 9850915, "displayName" : "miR-21 RISC:DNMT1 mRNA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2840, "y" : 1561 }, "minX" : 2577, "maxX" : 2914, "minY" : 1537, "maxY" : 1657, "prop" : { "x" : 2773, "y" : 1543, "width" : 135, "height" : 37 }, "textPosition" : { "x" : 2774, "y" : 1545 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2908, "y" : 1543 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2908, "y" : 1543 } } }, "connectors" : [ { "edgeId" : 15909, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 2787, "y" : 1583 }, "to" : { "x" : 2578, "y" : 1653 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2577, "y" : 1649 }, "b" : { "x" : 2579, "y" : 1657 }, "c" : { "x" : 2578, "y" : 1653 }, "type" : "STOP", "centre" : { "x" : 2578, "y" : 1653 } }, "isDisease" : true }, { "edgeId" : 15912, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 16424, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1389, "y" : 2975 }, "minX" : 1369, "maxX" : 1433, "minY" : 2933, "maxY" : 2991, "prop" : { "x" : 1369, "y" : 2960, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1373, "y" : 2965 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1404, "y" : 2965 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1404, "y" : 2965 } } }, "connectors" : [ { "edgeId" : 16419, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1405, "y" : 2957 }, "to" : { "x" : 1433, "y" : 2933 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1413, "y" : 2939 }, "b" : { "x" : 1425, "y" : 2951 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1419, "y" : 2945 } } }, "isDisease" : true } ] }, { "id" : 16425, "reactomeId" : 450250, "displayName" : "JUN", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1466, "y" : 2974 }, "minX" : 1433, "maxX" : 1495, "minY" : 2933, "maxY" : 2987, "prop" : { "x" : 1444, "y" : 2961, "width" : 45, "height" : 26 }, "textPosition" : { "x" : 1452, "y" : 2963 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1489, "y" : 2961 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1489, "y" : 2961 } } }, "connectors" : [ { "edgeId" : 16419, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1455, "y" : 2958 }, "to" : { "x" : 1433, "y" : 2933 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 16431, "reactomeId" : 3786256, "displayName" : "CDKN1A gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1658, "y" : 2943 }, "minX" : 1621, "maxX" : 1703, "minY" : 2915, "maxY" : 2969, "prop" : { "x" : 1621, "y" : 2917, "width" : 75, "height" : 52 }, "textPosition" : { "x" : 1628, "y" : 2944 }, "connectors" : [ { "edgeId" : 16430, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1703, "y" : 2915 }, "b" : { "x" : 1696, "y" : 2919 }, "c" : { "x" : 1703, "y" : 2923 }, "type" : "ARROW", "centre" : { "x" : 1703, "y" : 2923 } } }, { "id" : 16432, "reactomeId" : 182585, "displayName" : "CDKN1A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1794, "y" : 2920 }, "minX" : 1765, "maxX" : 1830, "minY" : 2903, "maxY" : 2932, "prop" : { "x" : 1765, "y" : 2909, "width" : 59, "height" : 23 }, "textPosition" : { "x" : 1766, "y" : 2910 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1824, "y" : 2909 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1824, "y" : 2909 } } }, "connectors" : [ { "edgeId" : 16430, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15409, "reactomeId" : 2187294, "displayName" : "JUNB gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1768, "y" : 2628 }, "minX" : 1734, "maxX" : 1810, "minY" : 2600, "maxY" : 2654, "prop" : { "x" : 1734, "y" : 2602, "width" : 69, "height" : 52 }, "textPosition" : { "x" : 1748, "y" : 2629 }, "connectors" : [ { "edgeId" : 15408, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1810, "y" : 2600 }, "b" : { "x" : 1803, "y" : 2604 }, "c" : { "x" : 1810, "y" : 2608 }, "type" : "ARROW", "centre" : { "x" : 1810, "y" : 2608 } } }, { "id" : 15410, "reactomeId" : 2186795, "displayName" : "JUNB", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2479, "y" : 2697 }, "minX" : 2308, "maxX" : 2504, "minY" : 2680, "maxY" : 2709, "prop" : { "x" : 2461, "y" : 2686, "width" : 37, "height" : 23 }, "textPosition" : { "x" : 2461, "y" : 2687 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2498, "y" : 2686 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2498, "y" : 2686 } } }, "connectors" : [ { "edgeId" : 15435, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 16120, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2458, "y" : 2696 }, "to" : { "x" : 2308, "y" : 2695 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2377, "y" : 2689 }, "b" : { "x" : 2389, "y" : 2701 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2383, "y" : 2695 } } }, "isDisease" : true } ] }, { "id" : 15413, "reactomeId" : 5674341, "displayName" : "p-T,Y MAPK monomers and dimers", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2035, "y" : 2563 }, "minX" : 1904, "maxX" : 2085, "minY" : 2452, "maxY" : 2607, "prop" : { "x" : 1985, "y" : 2538, "width" : 100, "height" : 51 }, "textPosition" : { "x" : 1995, "y" : 2539 }, "connectors" : [ { "edgeId" : 15408, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1979, "y" : 2579 }, "to" : { "x" : 1904, "y" : 2605 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1909, "y" : 2599 }, "b" : { "x" : 1904, "y" : 2605 }, "c" : { "x" : 1912, "y" : 2607 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1912, "y" : 2607 } }, "isDisease" : true }, { "edgeId" : 15472, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 2036, "y" : 2532 }, "to" : { "x" : 2040, "y" : 2452 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2044, "y" : 2459 }, "b" : { "x" : 2040, "y" : 2452 }, "c" : { "x" : 2036, "y" : 2459 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2036, "y" : 2459 } }, "isDisease" : true } ] }, { "id" : 15926, "reactomeId" : 5660405, "displayName" : "DNMT1 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 2246, "y" : 1693 }, "minX" : 2204, "maxX" : 2298, "minY" : 1665, "maxY" : 1826, "prop" : { "x" : 2204, "y" : 1667, "width" : 85, "height" : 52 }, "textPosition" : { "x" : 2219, "y" : 1694 }, "connectors" : [ { "edgeId" : 15925, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 16020, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2298, "y" : 1669 }, "to" : { "x" : 2248, "y" : 1826 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 2296, "y" : 1665 }, "b" : { "x" : 2289, "y" : 1669 }, "c" : { "x" : 2296, "y" : 1673 }, "type" : "ARROW", "centre" : { "x" : 2296, "y" : 1673 } } }, { "id" : 16438, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1138, "y" : 2668 }, "minX" : 1113, "maxX" : 1160, "minY" : 2652, "maxY" : 2719, "prop" : { "x" : 1118, "y" : 2653, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1122, "y" : 2658 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1154, "y" : 2658 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1154, "y" : 2658 } } }, "connectors" : [ { "edgeId" : 16394, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1130, "y" : 2687 }, "to" : { "x" : 1113, "y" : 2719 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1115, "y" : 2697 }, "b" : { "x" : 1127, "y" : 2709 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1121, "y" : 2703 } } }, "endShape" : { "a" : { "x" : 1130, "y" : 2695 }, "b" : { "x" : 1130, "y" : 2687 }, "c" : { "x" : 1123, "y" : 2691 }, "type" : "ARROW", "centre" : { "x" : 1123, "y" : 2691 } }, "isDisease" : true } ] }, { "id" : 16439, "reactomeId" : 9850925, "displayName" : "p-T,Y MAPK8,9", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1113, "y" : 2919 }, "minX" : 1077, "maxX" : 1150, "minY" : 2719, "maxY" : 2937, "prop" : { "x" : 1077, "y" : 2901, "width" : 73, "height" : 36 }, "textPosition" : { "x" : 1083, "y" : 2901 }, "connectors" : [ { "edgeId" : 16394, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1113, "y" : 2895 }, "to" : { "x" : 1113, "y" : 2719 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1109, "y" : 2888 }, "b" : { "x" : 1113, "y" : 2895 }, "c" : { "x" : 1117, "y" : 2888 }, "type" : "ARROW", "centre" : { "x" : 1117, "y" : 2888 } }, "isDisease" : true }, { "edgeId" : 16452, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15927, "reactomeId" : 9850875, "displayName" : "AcK685-p-Y705, S727-STAT3 dimer:DNMT1 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2530, "y" : 1772 }, "minX" : 2467, "maxX" : 2599, "minY" : 1701, "maxY" : 1798, "prop" : { "x" : 2467, "y" : 1747, "width" : 126, "height" : 51 }, "textPosition" : { "x" : 2467, "y" : 1749 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2593, "y" : 1747 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2593, "y" : 1747 } } }, "connectors" : [ { "edgeId" : 15925, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 2528, "y" : 1744 }, "to" : { "x" : 2525, "y" : 1701 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2529, "y" : 1708 }, "b" : { "x" : 2525, "y" : 1701 }, "c" : { "x" : 2521, "y" : 1708 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2521, "y" : 1708 } }, "isDisease" : true }, { "edgeId" : 16020, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 13882, "reactomeId" : 9701478, "displayName" : "Active ALK:JAK3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 291, "y" : 1396 }, "isFadeOut" : true, "minX" : 241, "maxX" : 395, "minY" : 1385, "maxY" : 1522, "prop" : { "x" : 241, "y" : 1385, "width" : 101, "height" : 23 }, "textPosition" : { "x" : 241, "y" : 1387 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 13881, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 292, "y" : 1411 }, "to" : { "x" : 300, "y" : 1499 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13881, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 285, "y" : 1411 }, "to" : { "x" : 248, "y" : 1485 } }, { "from" : { "x" : 248, "y" : 1485 }, "to" : { "x" : 286, "y" : 1516 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 289, "y" : 1518 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 289, "y" : 1518 } } }, { "edgeId" : 13886, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13891, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 312, "y" : 1411 }, "to" : { "x" : 395, "y" : 1451 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 320, "y" : 1410 }, "b" : { "x" : 312, "y" : 1411 }, "c" : { "x" : 317, "y" : 1418 }, "type" : "ARROW", "centre" : { "x" : 317, "y" : 1418 } } } ] }, { "id" : 13883, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 352, "y" : 1458 }, "isFadeOut" : true, "minX" : 300, "maxX" : 372, "minY" : 1443, "maxY" : 1499, "prop" : { "x" : 332, "y" : 1443, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 336, "y" : 1448 }, "connectors" : [ { "edgeId" : 13881, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 329, "y" : 1473 }, "to" : { "x" : 300, "y" : 1499 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13884, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 346, "y" : 1565 }, "isFadeOut" : true, "minX" : 298, "maxX" : 367, "minY" : 1550, "maxY" : 1581, "prop" : { "x" : 326, "y" : 1550, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 330, "y" : 1555 }, "connectors" : [ { "edgeId" : 13881, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 323, "y" : 1560 }, "to" : { "x" : 298, "y" : 1555 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 315, "y" : 1563 }, "b" : { "x" : 323, "y" : 1560 }, "c" : { "x" : 317, "y" : 1555 }, "type" : "ARROW", "centre" : { "x" : 317, "y" : 1555 } } } ] }, { "id" : 13885, "reactomeId" : 9701475, "displayName" : "Active ALK:p-Y980 JAK3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 301, "y" : 1626 }, "isFadeOut" : true, "minX" : 240, "maxX" : 391, "minY" : 1555, "maxY" : 1645, "prop" : { "x" : 240, "y" : 1608, "width" : 123, "height" : 37 }, "textPosition" : { "x" : 241, "y" : 1610 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 13881, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 300, "y" : 1605 }, "to" : { "x" : 298, "y" : 1555 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 296, "y" : 1598 }, "b" : { "x" : 300, "y" : 1605 }, "c" : { "x" : 304, "y" : 1598 }, "type" : "ARROW", "centre" : { "x" : 304, "y" : 1598 } } }, { "edgeId" : 13891, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 334, "y" : 1605 }, "to" : { "x" : 391, "y" : 1577 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13887, "reactomeId" : 451893, "displayName" : "JAK3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 625, "y" : 1318 }, "isFadeOut" : true, "minX" : 512, "maxX" : 644, "minY" : 1264, "maxY" : 1330, "prop" : { "x" : 607, "y" : 1307, "width" : 37, "height" : 23 }, "textPosition" : { "x" : 608, "y" : 1308 }, "connectors" : [ { "edgeId" : 13886, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 604, "y" : 1309 }, "to" : { "x" : 512, "y" : 1264 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13892, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 429, "y" : 1610 }, "isFadeOut" : true, "minX" : 391, "maxX" : 451, "minY" : 1577, "maxY" : 1626, "prop" : { "x" : 408, "y" : 1595, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 412, "y" : 1600 }, "connectors" : [ { "edgeId" : 13891, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 411, "y" : 1592 }, "to" : { "x" : 391, "y" : 1577 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13894, "reactomeId" : 197938, "displayName" : "PTPN6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 462, "y" : 1494 }, "minX" : 405, "maxX" : 492, "minY" : 1477, "maxY" : 1506, "prop" : { "x" : 438, "y" : 1483, "width" : 48, "height" : 23 }, "textPosition" : { "x" : 438, "y" : 1484 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 486, "y" : 1483 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 486, "y" : 1483 } } }, "connectors" : [ { "edgeId" : 13891, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 435, "y" : 1493 }, "to" : { "x" : 413, "y" : 1493 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 409, "y" : 1493 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 409, "y" : 1493 } } }, { "edgeId" : 15997, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 13896, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 447, "y" : 1430 }, "isFadeOut" : true, "minX" : 395, "maxX" : 461, "minY" : 1415, "maxY" : 1451, "prop" : { "x" : 434, "y" : 1415, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 438, "y" : 1420 }, "connectors" : [ { "edgeId" : 13891, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 431, "y" : 1435 }, "to" : { "x" : 395, "y" : 1451 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 426, "y" : 1441 }, "b" : { "x" : 431, "y" : 1435 }, "c" : { "x" : 423, "y" : 1434 }, "type" : "ARROW", "centre" : { "x" : 423, "y" : 1434 } } } ] }, { "id" : 15434, "reactomeId" : 9725326, "displayName" : "JUNB mRNA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "RNA", "position" : { "x" : 2804, "y" : 2593 }, "minX" : 2750, "maxX" : 2859, "minY" : 2574, "maxY" : 2613, "prop" : { "x" : 2750, "y" : 2574, "width" : 109, "height" : 39 }, "textPosition" : { "x" : 2766, "y" : 2583 }, "connectors" : [ { "edgeId" : 15408, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15435, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 13898, "reactomeId" : 539044, "displayName" : "STAT3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 919, "y" : 1039 }, "minX" : 887, "maxX" : 1105, "minY" : 996, "maxY" : 1537, "prop" : { "x" : 896, "y" : 1028, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 896, "y" : 1029 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 943, "y" : 1028 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 943, "y" : 1028 } } }, "connectors" : [ { "edgeId" : 13897, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 946, "y" : 1033 }, "to" : { "x" : 1105, "y" : 996 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14773, "type" : "INPUT", "segments" : [ { "from" : { "x" : 918, "y" : 1054 }, "to" : { "x" : 887, "y" : 1537 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15436, "reactomeId" : 165727, "displayName" : "p-5S-RPS6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2835, "y" : 2687 }, "minX" : 2649, "maxX" : 2879, "minY" : 2667, "maxY" : 2708, "prop" : { "x" : 2797, "y" : 2673, "width" : 76, "height" : 29 }, "innerProp" : { "x" : 2797, "y" : 2679, "width" : 70, "height" : 17 }, "textPosition" : { "x" : 2799, "y" : 2677 }, "nodeAttachments" : [ { "reactomeId" : 165729, "label" : "P", "description" : "O-phospho-L-serine at 235", "shape" : { "a" : { "x" : 2807, "y" : 2667 }, "b" : { "x" : 2819, "y" : 2679 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 2813, "y" : 2673 } } }, { "reactomeId" : 165735, "label" : "P", "description" : "O-phospho-L-serine at 236", "shape" : { "a" : { "x" : 2823, "y" : 2667 }, "b" : { "x" : 2835, "y" : 2679 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 2829, "y" : 2673 } } }, { "reactomeId" : 165734, "label" : "P", "description" : "O-phospho-L-serine at 240", "shape" : { "a" : { "x" : 2839, "y" : 2667 }, "b" : { "x" : 2851, "y" : 2679 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 2845, "y" : 2673 } } }, { "reactomeId" : 165732, "label" : "P", "description" : "O-phospho-L-serine at 244", "shape" : { "a" : { "x" : 2867, "y" : 2683 }, "b" : { "x" : 2879, "y" : 2695 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 2873, "y" : 2689 } } }, { "reactomeId" : 165731, "label" : "P", "description" : "O-phospho-L-serine at 247", "shape" : { "a" : { "x" : 2851, "y" : 2696 }, "b" : { "x" : 2863, "y" : 2708 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 2857, "y" : 2702 } } } ], "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2873, "y" : 2673 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2873, "y" : 2673 } } }, "connectors" : [ { "edgeId" : 15435, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 2794, "y" : 2687 }, "to" : { "x" : 2649, "y" : 2691 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2656, "y" : 2687 }, "b" : { "x" : 2649, "y" : 2691 }, "c" : { "x" : 2656, "y" : 2695 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2656, "y" : 2695 } }, "isDisease" : true } ] }, { "id" : 14926, "reactomeId" : 9724097, "displayName" : "ALK fusion dimers:p-3Y SHC1:GRB2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2089, "y" : 953 }, "isDisease" : true, "minX" : 2031, "maxX" : 2154, "minY" : 929, "maxY" : 972, "prop" : { "x" : 2031, "y" : 935, "width" : 117, "height" : 37 }, "textPosition" : { "x" : 2047, "y" : 923 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2148, "y" : 935 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2148, "y" : 935 } } }, "connectors" : [ { "edgeId" : 14925, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 13907, "reactomeId" : 539048, "displayName" : "p-Y705,S727-STAT3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1066, "y" : 1186 }, "isFadeOut" : true, "minX" : 1018, "maxX" : 1114, "minY" : 1162, "maxY" : 1265, "prop" : { "x" : 1018, "y" : 1168, "width" : 96, "height" : 37 }, "innerProp" : { "x" : 1018, "y" : 1174, "width" : 96, "height" : 31 }, "textPosition" : { "x" : 1020, "y" : 1169 }, "nodeAttachments" : [ { "reactomeId" : 539016, "label" : "P", "description" : "O-phospho-L-serine at 727", "shape" : { "a" : { "x" : 1027, "y" : 1162 }, "b" : { "x" : 1039, "y" : 1174 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1033, "y" : 1168 } } }, { "reactomeId" : 539045, "label" : "P", "description" : "O4'-phospho-L-tyrosine at 705", "shape" : { "a" : { "x" : 1043, "y" : 1162 }, "b" : { "x" : 1055, "y" : 1174 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1049, "y" : 1168 } } } ], "connectors" : [ { "edgeId" : 13897, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13977, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1058, "y" : 1253 }, "b" : { "x" : 1070, "y" : 1265 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1064, "y" : 1259 } } } } ] }, { "id" : 92, "reactomeId" : 9700086, "displayName" : "(PTN,MDK):ALK dimer", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 318, "y" : 2215 }, "isFadeOut" : true, "minX" : 267, "maxX" : 369, "minY" : 2197, "maxY" : 2318, "prop" : { "x" : 267, "y" : 2197, "width" : 102, "height" : 37 }, "textPosition" : { "x" : 267, "y" : 2198 }, "connectors" : [ { "edgeId" : 106, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 315, "y" : 2240 }, "to" : { "x" : 306, "y" : 2318 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 318, "y" : 2247 }, "b" : { "x" : 315, "y" : 2240 }, "c" : { "x" : 310, "y" : 2246 }, "type" : "ARROW", "centre" : { "x" : 310, "y" : 2246 } } } ] }, { "id" : 14429, "reactomeId" : 9712072, "displayName" : "ALK fusions:p-4Y PLCG1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 347, "y" : 1065 }, "isDisease" : true, "minX" : 291, "maxX" : 410, "minY" : 980, "maxY" : 1084, "prop" : { "x" : 291, "y" : 1047, "width" : 113, "height" : 37 }, "textPosition" : { "x" : 291, "y" : 1049 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 404, "y" : 1047 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 404, "y" : 1047 } } }, "connectors" : [ { "edgeId" : 14426, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 336, "y" : 1044 }, "to" : { "x" : 301, "y" : 980 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 329, "y" : 1040 }, "b" : { "x" : 336, "y" : 1044 }, "c" : { "x" : 336, "y" : 1036 }, "type" : "ARROW", "centre" : { "x" : 336, "y" : 1036 } }, "isDisease" : true } ] }, { "id" : 96, "reactomeId" : 9700013, "displayName" : "(PTN,MDK):p-7Y ALK dimer", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 323, "y" : 2464 }, "isFadeOut" : true, "minX" : 268, "maxX" : 378, "minY" : 2376, "maxY" : 2483, "prop" : { "x" : 268, "y" : 2446, "width" : 110, "height" : 37 }, "textPosition" : { "x" : 269, "y" : 2447 }, "connectors" : [ { "edgeId" : 106, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 320, "y" : 2440 }, "to" : { "x" : 309, "y" : 2376 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 15461, "reactomeId" : 9725309, "displayName" : "BCL2A1 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1447, "y" : 3046 }, "minX" : 1404, "maxX" : 1497, "minY" : 3018, "maxY" : 3072, "prop" : { "x" : 1404, "y" : 3020, "width" : 86, "height" : 52 }, "textPosition" : { "x" : 1418, "y" : 3047 }, "connectors" : [ { "edgeId" : 15460, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1497, "y" : 3018 }, "b" : { "x" : 1490, "y" : 3022 }, "c" : { "x" : 1497, "y" : 3026 }, "type" : "ARROW", "centre" : { "x" : 1497, "y" : 3026 } } }, { "id" : 15462, "reactomeId" : 9725307, "displayName" : "BCL2A1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1576, "y" : 3146 }, "minX" : 1544, "maxX" : 1614, "minY" : 3129, "maxY" : 3158, "prop" : { "x" : 1544, "y" : 3135, "width" : 64, "height" : 23 }, "textPosition" : { "x" : 1549, "y" : 3136 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1608, "y" : 3135 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1608, "y" : 3135 } } }, "connectors" : [ { "edgeId" : 15460, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 107, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 424, "y" : 2408 }, "isFadeOut" : true, "minX" : 309, "maxX" : 446, "minY" : 2376, "maxY" : 2424, "prop" : { "x" : 403, "y" : 2393, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 407, "y" : 2398 }, "connectors" : [ { "edgeId" : 106, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 400, "y" : 2402 }, "to" : { "x" : 309, "y" : 2376 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 348, "y" : 2383 }, "b" : { "x" : 360, "y" : 2395 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 354, "y" : 2389 } } } } ] }, { "id" : 108, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 373, "y" : 2261 }, "isFadeOut" : true, "minX" : 306, "maxX" : 387, "minY" : 2246, "maxY" : 2318, "prop" : { "x" : 360, "y" : 2246, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 364, "y" : 2251 }, "connectors" : [ { "edgeId" : 106, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 357, "y" : 2272 }, "to" : { "x" : 306, "y" : 2318 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 325, "y" : 2289 }, "b" : { "x" : 337, "y" : 2301 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 331, "y" : 2295 } } }, "endShape" : { "a" : { "x" : 355, "y" : 2280 }, "b" : { "x" : 357, "y" : 2272 }, "c" : { "x" : 349, "y" : 2274 }, "type" : "ARROW", "centre" : { "x" : 349, "y" : 2274 } } } ] }, { "id" : 109, "reactomeId" : 9699799, "displayName" : "C4S-PTPRZ1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 207, "y" : 2215 }, "isFadeOut" : true, "minX" : 113, "maxX" : 302, "minY" : 2194, "maxY" : 2352, "prop" : { "x" : 162, "y" : 2199, "width" : 90, "height" : 32 }, "innerProp" : { "x" : 168, "y" : 2199, "width" : 84, "height" : 26 }, "textPosition" : { "x" : 165, "y" : 2204 }, "nodeAttachments" : [ { "reactomeId" : 9699893, "label" : "G", "description" : "O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at 637", "shape" : { "a" : { "x" : 156, "y" : 2194 }, "b" : { "x" : 168, "y" : 2206 }, "s" : "G", "type" : "BOX", "empty" : true, "centre" : { "x" : 162, "y" : 2200 } } }, { "reactomeId" : 9699823, "label" : "G", "description" : "O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at 1549", "shape" : { "a" : { "x" : 157, "y" : 2210 }, "b" : { "x" : 169, "y" : 2222 }, "s" : "G", "type" : "BOX", "empty" : true, "centre" : { "x" : 163, "y" : 2216 } } }, { "reactomeId" : 9699898, "label" : "G", "description" : "O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at 1551", "shape" : { "a" : { "x" : 181, "y" : 2225 }, "b" : { "x" : 193, "y" : 2237 }, "s" : "G", "type" : "BOX", "empty" : true, "centre" : { "x" : 187, "y" : 2231 } } }, { "reactomeId" : 9699857, "label" : "G", "description" : "O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at 997", "shape" : { "a" : { "x" : 166, "y" : 2225 }, "b" : { "x" : 178, "y" : 2237 }, "s" : "G", "type" : "BOX", "empty" : true, "centre" : { "x" : 172, "y" : 2231 } } } ], "connectors" : [ { "edgeId" : 15621, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 159, "y" : 2226 }, "to" : { "x" : 113, "y" : 2240 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 106, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 217, "y" : 2234 }, "to" : { "x" : 296, "y" : 2345 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 298, "y" : 2348 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 298, "y" : 2348 } } } ] }, { "id" : 15473, "reactomeId" : 3858376, "displayName" : "CEBPB gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1899, "y" : 2458 }, "minX" : 1861, "maxX" : 1945, "minY" : 2430, "maxY" : 2484, "prop" : { "x" : 1861, "y" : 2432, "width" : 77, "height" : 52 }, "textPosition" : { "x" : 1873, "y" : 2459 }, "connectors" : [ { "edgeId" : 15472, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1945, "y" : 2430 }, "b" : { "x" : 1938, "y" : 2434 }, "c" : { "x" : 1945, "y" : 2438 }, "type" : "ARROW", "centre" : { "x" : 1945, "y" : 2438 } } }, { "id" : 114, "reactomeId" : 9700012, "displayName" : "(PTN,MDK):PTPRZ", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 204, "y" : 2324 }, "isFadeOut" : true, "minX" : 148, "maxX" : 261, "minY" : 2313, "maxY" : 2365, "prop" : { "x" : 148, "y" : 2313, "width" : 113, "height" : 23 }, "textPosition" : { "x" : 166, "y" : 2301 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 15621, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 115, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 191, "y" : 2353 }, "b" : { "x" : 203, "y" : 2365 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 197, "y" : 2359 } } } } ] }, { "id" : 15474, "reactomeId" : 381378, "displayName" : "CEBPB", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2168, "y" : 2434 }, "minX" : 2146, "maxX" : 2197, "minY" : 2417, "maxY" : 2446, "prop" : { "x" : 2146, "y" : 2423, "width" : 45, "height" : 23 }, "textPosition" : { "x" : 2148, "y" : 2417 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2191, "y" : 2423 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2191, "y" : 2423 } } }, "connectors" : [ { "edgeId" : 15472, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15475, "reactomeId" : 9713536, "displayName" : "IRS- and FRS-binding ALK fusion proteins", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1444, "y" : 523 }, "isDisease" : true, "minX" : 1384, "maxX" : 1606, "minY" : 432, "maxY" : 549, "prop" : { "x" : 1384, "y" : 498, "width" : 120, "height" : 51 }, "textPosition" : { "x" : 1393, "y" : 499 }, "connectors" : [ { "edgeId" : 14601, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1510, "y" : 517 }, "to" : { "x" : 1606, "y" : 509 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14708, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1455, "y" : 492 }, "to" : { "x" : 1484, "y" : 432 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 116, "reactomeId" : 9700009, "displayName" : "(PTN,MDK):PTPRZ oligomers", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 210, "y" : 2431 }, "isFadeOut" : true, "minX" : 152, "maxX" : 300, "minY" : 2360, "maxY" : 2450, "prop" : { "x" : 152, "y" : 2413, "width" : 117, "height" : 37 }, "textPosition" : { "x" : 151, "y" : 2415 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 106, "type" : "INHIBITOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 234, "y" : 2410 }, "to" : { "x" : 298, "y" : 2363 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 296, "y" : 2360 }, "b" : { "x" : 300, "y" : 2366 }, "c" : { "x" : 298, "y" : 2363 }, "type" : "STOP", "centre" : { "x" : 298, "y" : 2363 } } }, { "edgeId" : 115, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 15991, "reactomeId" : 205021, "displayName" : "HDAC1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1423, "y" : 1862 }, "minX" : 1398, "maxX" : 1556, "minY" : 1845, "maxY" : 1907, "prop" : { "x" : 1398, "y" : 1851, "width" : 51, "height" : 23 }, "textPosition" : { "x" : 1398, "y" : 1852 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1449, "y" : 1851 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1449, "y" : 1851 } } }, "connectors" : [ { "edgeId" : 15989, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1452, "y" : 1870 }, "to" : { "x" : 1556, "y" : 1907 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15992, "reactomeId" : 9850942, "displayName" : "pY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1306, "y" : 1904 }, "isDisease" : true, "minX" : 788, "maxX" : 1375, "minY" : 1873, "maxY" : 2028, "prop" : { "x" : 1243, "y" : 1879, "width" : 126, "height" : 51 }, "textPosition" : { "x" : 1243, "y" : 1867 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1369, "y" : 1879 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1369, "y" : 1879 } } }, "connectors" : [ { "edgeId" : 15989, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15997, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1240, "y" : 1918 }, "to" : { "x" : 789, "y" : 2024 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 788, "y" : 2020 }, "b" : { "x" : 790, "y" : 2028 }, "c" : { "x" : 789, "y" : 2024 }, "type" : "STOP", "centre" : { "x" : 789, "y" : 2024 } }, "isDisease" : true } ] }, { "id" : 14466, "reactomeId" : 179856, "displayName" : "PI(4,5)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 253, "y" : 394 }, "minX" : 218, "maxX" : 295, "minY" : 378, "maxY" : 455, "prop" : { "x" : 218, "y" : 379, "width" : 70, "height" : 31 }, "textPosition" : { "x" : 220, "y" : 384 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 283, "y" : 384 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 283, "y" : 384 } } }, "connectors" : [ { "edgeId" : 307, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 250, "y" : 413 }, "to" : { "x" : 243, "y" : 455 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14574, "type" : "INPUT", "segments" : [ { "from" : { "x" : 264, "y" : 413 }, "to" : { "x" : 295, "y" : 449 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14467, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 375, "y" : 407 }, "minX" : 243, "maxX" : 396, "minY" : 391, "maxY" : 455, "prop" : { "x" : 355, "y" : 392, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 359, "y" : 397 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 390, "y" : 397 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 390, "y" : 397 } } }, "connectors" : [ { "edgeId" : 307, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 352, "y" : 414 }, "to" : { "x" : 243, "y" : 455 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14574, "type" : "INPUT", "segments" : [ { "from" : { "x" : 352, "y" : 417 }, "to" : { "x" : 295, "y" : 449 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 16005, "reactomeId" : 1257604, "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2839, "y" : 2840 }, "minX" : 2770, "maxX" : 2908, "minY" : 2810, "maxY" : 2870, "prop" : { "x" : 2770, "y" : 2810, "width" : 138, "height" : 60 }, "textPosition" : { "x" : 2772, "y" : 2818 }, "connectors" : [ ] }, { "id" : 15511, "reactomeId" : 9842597, "displayName" : "ALKAL2:(ALKAL1)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 206, "y" : 17 }, "isFadeOut" : true, "minX" : 152, "maxX" : 261, "minY" : 6, "maxY" : 122, "prop" : { "x" : 152, "y" : 6, "width" : 109, "height" : 23 }, "textPosition" : { "x" : 152, "y" : 7 }, "connectors" : [ { "edgeId" : 15513, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 210, "y" : 35 }, "to" : { "x" : 245, "y" : 122 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 15512, "reactomeId" : 9842608, "displayName" : "ALK dimer:ALKAL2:(ALKAL1)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 483, "y" : 166 }, "isFadeOut" : true, "minX" : 423, "maxX" : 544, "minY" : 148, "maxY" : 185, "prop" : { "x" : 423, "y" : 148, "width" : 121, "height" : 37 }, "textPosition" : { "x" : 424, "y" : 150 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 15513, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13978, "reactomeId" : 9701454, "displayName" : "p-Y705,S727-STAT3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1070, "y" : 1511 }, "isFadeOut" : true, "minX" : 1022, "maxX" : 1118, "minY" : 1493, "maxY" : 1530, "prop" : { "x" : 1022, "y" : 1493, "width" : 96, "height" : 37 }, "textPosition" : { "x" : 1024, "y" : 1495 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 13977, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13979, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13980, "reactomeId" : 9701457, "displayName" : "p-Y705,S727-STAT3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1634, "y" : 1489 }, "minX" : 1355, "maxX" : 2143, "minY" : 1181, "maxY" : 2436, "prop" : { "x" : 1586, "y" : 1471, "width" : 96, "height" : 37 }, "textPosition" : { "x" : 1588, "y" : 1473 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1682, "y" : 1471 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1682, "y" : 1471 } } }, "connectors" : [ { "edgeId" : 14088, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1685, "y" : 1497 }, "to" : { "x" : 1761, "y" : 1512 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14089, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1681, "y" : 1468 }, "to" : { "x" : 1787, "y" : 1430 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1686, "y" : 1462 }, "b" : { "x" : 1681, "y" : 1468 }, "c" : { "x" : 1689, "y" : 1469 }, "type" : "ARROW", "centre" : { "x" : 1689, "y" : 1469 } } }, { "edgeId" : 15625, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 16906, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1613, "y" : 1511 }, "to" : { "x" : 1355, "y" : 1735 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1358, "y" : 1727 }, "b" : { "x" : 1355, "y" : 1735 }, "c" : { "x" : 1363, "y" : 1733 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1363, "y" : 1733 } }, "isDisease" : true }, { "edgeId" : 14095, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1604, "y" : 1468 }, "to" : { "x" : 1460, "y" : 1381 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14097, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1644, "y" : 1468 }, "to" : { "x" : 1807, "y" : 1181 } }, { "from" : { "x" : 1807, "y" : 1181 }, "to" : { "x" : 2031, "y" : 1183 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15671, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1636, "y" : 1511 }, "to" : { "x" : 1696, "y" : 1932 } }, { "from" : { "x" : 1696, "y" : 1932 }, "to" : { "x" : 1723, "y" : 2228 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1718, "y" : 2221 }, "b" : { "x" : 1723, "y" : 2228 }, "c" : { "x" : 1726, "y" : 2221 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1726, "y" : 2221 } }, "isDisease" : true }, { "edgeId" : 15674, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1642, "y" : 1511 }, "to" : { "x" : 1972, "y" : 2233 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15723, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1644, "y" : 1511 }, "to" : { "x" : 1963, "y" : 2063 } }, { "from" : { "x" : 1963, "y" : 2063 }, "to" : { "x" : 2143, "y" : 2011 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15472, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1639, "y" : 1511 }, "to" : { "x" : 1810, "y" : 2104 } }, { "from" : { "x" : 1810, "y" : 2104 }, "to" : { "x" : 2035, "y" : 2436 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2028, "y" : 2433 }, "b" : { "x" : 2035, "y" : 2436 }, "c" : { "x" : 2034, "y" : 2428 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2034, "y" : 2428 } }, "isDisease" : true }, { "edgeId" : 15989, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1630, "y" : 1511 }, "to" : { "x" : 1556, "y" : 1907 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 13979, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 16061, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1659, "y" : 1511 }, "to" : { "x" : 1886, "y" : 1671 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1884, "y" : 1674 }, "b" : { "x" : 1888, "y" : 1668 }, "c" : { "x" : 1886, "y" : 1671 }, "type" : "STOP", "centre" : { "x" : 1886, "y" : 1671 } }, "isDisease" : true }, { "edgeId" : 15817, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1632, "y" : 1511 }, "to" : { "x" : 1583, "y" : 2093 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15519, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 789, "y" : 257 }, "isFadeOut" : true, "minX" : 769, "maxX" : 816, "minY" : 210, "maxY" : 273, "prop" : { "x" : 769, "y" : 242, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 773, "y" : 247 }, "connectors" : [ { "edgeId" : 103, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 797, "y" : 239 }, "to" : { "x" : 816, "y" : 210 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 800, "y" : 218 }, "b" : { "x" : 812, "y" : 230 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 806, "y" : 224 } } } } ] }, { "id" : 15520, "reactomeId" : 9850908, "displayName" : "ligand-bound ALK dimer", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 718, "y" : 208 }, "isFadeOut" : true, "minX" : 613, "maxX" : 880, "minY" : 155, "maxY" : 227, "prop" : { "x" : 659, "y" : 190, "width" : 118, "height" : 37 }, "textPosition" : { "x" : 659, "y" : 191 }, "connectors" : [ { "edgeId" : 103, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 783, "y" : 209 }, "to" : { "x" : 816, "y" : 210 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 103, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 774, "y" : 184 }, "to" : { "x" : 821, "y" : 174 } }, { "from" : { "x" : 821, "y" : 174 }, "to" : { "x" : 873, "y" : 202 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 876, "y" : 203 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 876, "y" : 203 } } }, { "edgeId" : 15480, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 681, "y" : 184 }, "to" : { "x" : 613, "y" : 155 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 175, "reactomeId" : 74769, "displayName" : "IRS1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1409, "y" : 339 }, "minX" : 1392, "maxX" : 1484, "minY" : 304, "maxY" : 432, "prop" : { "x" : 1392, "y" : 328, "width" : 34, "height" : 23 }, "textPosition" : { "x" : 1395, "y" : 322 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1426, "y" : 328 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1426, "y" : 328 } } }, "connectors" : [ { "edgeId" : 14708, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1418, "y" : 354 }, "to" : { "x" : 1484, "y" : 432 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 174, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1421, "y" : 325 }, "to" : { "x" : 1448, "y" : 304 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 176, "reactomeId" : 9699993, "displayName" : "Active ALK:IRS1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1491, "y" : 246 }, "isFadeOut" : true, "minX" : 1442, "maxX" : 1579, "minY" : 221, "maxY" : 261, "prop" : { "x" : 1442, "y" : 235, "width" : 98, "height" : 23 }, "textPosition" : { "x" : 1454, "y" : 223 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 174, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 177, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1543, "y" : 256 }, "to" : { "x" : 1559, "y" : 261 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 177, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1529, "y" : 232 }, "to" : { "x" : 1574, "y" : 221 } }, { "from" : { "x" : 1574, "y" : 221 }, "to" : { "x" : 1575, "y" : 236 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1575, "y" : 240 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1575, "y" : 240 } } } ] }, { "id" : 178, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1592, "y" : 301 }, "isFadeOut" : true, "minX" : 1559, "maxX" : 1640, "minY" : 196, "maxY" : 317, "prop" : { "x" : 1572, "y" : 286, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1576, "y" : 291 }, "connectors" : [ { "edgeId" : 177, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1579, "y" : 283 }, "to" : { "x" : 1559, "y" : 261 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 226, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1599, "y" : 283 }, "to" : { "x" : 1640, "y" : 196 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 1613, "y" : 233 }, "b" : { "x" : 1625, "y" : 245 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1619, "y" : 239 } } } } ] }, { "id" : 179, "reactomeId" : 9699983, "displayName" : "Active ALK:pY-IRS1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1773, "y" : 251 }, "isFadeOut" : true, "minX" : 1656, "maxX" : 1833, "minY" : 240, "maxY" : 263, "prop" : { "x" : 1713, "y" : 240, "width" : 120, "height" : 23 }, "textPosition" : { "x" : 1713, "y" : 242 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 177, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1710, "y" : 251 }, "to" : { "x" : 1656, "y" : 252 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1703, "y" : 255 }, "b" : { "x" : 1710, "y" : 251 }, "c" : { "x" : 1703, "y" : 247 }, "type" : "ARROW", "centre" : { "x" : 1703, "y" : 247 } } } ] }, { "id" : 180, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1687, "y" : 301 }, "isFadeOut" : true, "minX" : 1656, "maxX" : 1708, "minY" : 197, "maxY" : 317, "prop" : { "x" : 1667, "y" : 286, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1671, "y" : 291 }, "connectors" : [ { "edgeId" : 177, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1677, "y" : 283 }, "to" : { "x" : 1656, "y" : 252 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1670, "y" : 280 }, "b" : { "x" : 1677, "y" : 283 }, "c" : { "x" : 1676, "y" : 275 }, "type" : "ARROW", "centre" : { "x" : 1676, "y" : 275 } } }, { "edgeId" : 226, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1688, "y" : 283 }, "to" : { "x" : 1695, "y" : 197 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 1685, "y" : 234 }, "b" : { "x" : 1697, "y" : 246 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1691, "y" : 240 } } }, "endShape" : { "a" : { "x" : 1685, "y" : 276 }, "b" : { "x" : 1688, "y" : 283 }, "c" : { "x" : 1693, "y" : 276 }, "type" : "ARROW", "centre" : { "x" : 1693, "y" : 276 } } } ] }, { "id" : 15541, "reactomeId" : 9850879, "displayName" : "Active ALK dimer", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1218, "y" : 198 }, "isFadeOut" : true, "minX" : 246, "maxX" : 1448, "minY" : 187, "maxY" : 1264, "prop" : { "x" : 1165, "y" : 187, "width" : 107, "height" : 23 }, "textPosition" : { "x" : 1181, "y" : 181 }, "connectors" : [ { "edgeId" : 295, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1176, "y" : 216 }, "to" : { "x" : 712, "y" : 337 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13886, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1215, "y" : 216 }, "to" : { "x" : 1112, "y" : 715 } }, { "from" : { "x" : 1112, "y" : 715 }, "to" : { "x" : 512, "y" : 1264 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13897, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1216, "y" : 216 }, "to" : { "x" : 1105, "y" : 996 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 336, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1192, "y" : 216 }, "to" : { "x" : 246, "y" : 633 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 355, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1221, "y" : 216 }, "to" : { "x" : 1329, "y" : 536 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 103, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1159, "y" : 199 }, "to" : { "x" : 917, "y" : 209 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1152, "y" : 203 }, "b" : { "x" : 1159, "y" : 199 }, "c" : { "x" : 1152, "y" : 195 }, "type" : "ARROW", "centre" : { "x" : 1152, "y" : 195 } } }, { "edgeId" : 15773, "type" : "ACTIVATOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1219, "y" : 216 }, "to" : { "x" : 1309, "y" : 1196 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1304, "y" : 1189 }, "b" : { "x" : 1309, "y" : 1196 }, "c" : { "x" : 1312, "y" : 1189 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1312, "y" : 1189 } } }, { "edgeId" : 174, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1232, "y" : 216 }, "to" : { "x" : 1353, "y" : 306 } }, { "from" : { "x" : 1353, "y" : 306 }, "to" : { "x" : 1448, "y" : 304 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 181, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1229, "y" : 216 }, "to" : { "x" : 1424, "y" : 404 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 220, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1278, "y" : 198 }, "to" : { "x" : 1401, "y" : 199 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 182, "reactomeId" : 1169480, "displayName" : "SHC1-2,SHC1-3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1360, "y" : 429 }, "minX" : 1308, "maxX" : 1717, "minY" : 404, "maxY" : 586, "prop" : { "x" : 1308, "y" : 418, "width" : 105, "height" : 23 }, "textPosition" : { "x" : 1309, "y" : 419 }, "connectors" : [ { "edgeId" : 13587, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1386, "y" : 447 }, "to" : { "x" : 1717, "y" : 586 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 181, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1389, "y" : 412 }, "to" : { "x" : 1424, "y" : 404 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 183, "reactomeId" : 9699970, "displayName" : "Active ALK:SHC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1946, "y" : 219 }, "isFadeOut" : true, "minX" : 1894, "maxX" : 2057, "minY" : 180, "maxY" : 231, "prop" : { "x" : 1894, "y" : 208, "width" : 104, "height" : 23 }, "textPosition" : { "x" : 1909, "y" : 196 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 181, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 184, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2001, "y" : 220 }, "to" : { "x" : 2021, "y" : 221 } }, { "from" : { "x" : 2021, "y" : 221 }, "to" : { "x" : 2040, "y" : 222 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 184, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1962, "y" : 205 }, "to" : { "x" : 2003, "y" : 180 } }, { "from" : { "x" : 2003, "y" : 180 }, "to" : { "x" : 2050, "y" : 211 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2053, "y" : 213 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2053, "y" : 213 } } } ] }, { "id" : 15544, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 954, "y" : 249 }, "isFadeOut" : true, "minX" : 917, "maxX" : 975, "minY" : 209, "maxY" : 265, "prop" : { "x" : 934, "y" : 234, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 938, "y" : 239 }, "connectors" : [ { "edgeId" : 103, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 939, "y" : 231 }, "to" : { "x" : 917, "y" : 209 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 922, "y" : 214 }, "b" : { "x" : 934, "y" : 226 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 928, "y" : 220 } } }, "endShape" : { "a" : { "x" : 931, "y" : 229 }, "b" : { "x" : 939, "y" : 231 }, "c" : { "x" : 937, "y" : 223 }, "type" : "ARROW", "centre" : { "x" : 937, "y" : 223 } } } ] }, { "id" : 185, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2002, "y" : 265 }, "isFadeOut" : true, "minX" : 1982, "maxX" : 2040, "minY" : 222, "maxY" : 281, "prop" : { "x" : 1982, "y" : 250, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1986, "y" : 255 }, "connectors" : [ { "edgeId" : 184, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2015, "y" : 247 }, "to" : { "x" : 2040, "y" : 222 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 2021, "y" : 228 }, "b" : { "x" : 2033, "y" : 240 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2027, "y" : 234 } } } } ] }, { "id" : 186, "reactomeId" : 9700011, "displayName" : "Active ALK:p-3Y SHC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2198, "y" : 214 }, "isFadeOut" : true, "minX" : 2085, "maxX" : 2252, "minY" : 196, "maxY" : 233, "prop" : { "x" : 2145, "y" : 196, "width" : 107, "height" : 37 }, "textPosition" : { "x" : 2146, "y" : 198 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 184, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2142, "y" : 215 }, "to" : { "x" : 2085, "y" : 218 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2135, "y" : 219 }, "b" : { "x" : 2142, "y" : 215 }, "c" : { "x" : 2135, "y" : 211 }, "type" : "ARROW", "centre" : { "x" : 2135, "y" : 211 } } } ] }, { "id" : 187, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2123, "y" : 270 }, "isFadeOut" : true, "minX" : 2085, "maxX" : 2144, "minY" : 218, "maxY" : 286, "prop" : { "x" : 2103, "y" : 255, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 2107, "y" : 260 }, "connectors" : [ { "edgeId" : 184, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2111, "y" : 252 }, "to" : { "x" : 2085, "y" : 218 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 2092, "y" : 229 }, "b" : { "x" : 2104, "y" : 241 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2098, "y" : 235 } } }, "endShape" : { "a" : { "x" : 2104, "y" : 249 }, "b" : { "x" : 2111, "y" : 252 }, "c" : { "x" : 2110, "y" : 244 }, "type" : "ARROW", "centre" : { "x" : 2110, "y" : 244 } } } ] }, { "id" : 15550, "reactomeId" : 9725313, "displayName" : "MYCN gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1250, "y" : 1227 }, "isFadeOut" : true, "minX" : 1213, "maxX" : 1295, "minY" : 1199, "maxY" : 1253, "prop" : { "x" : 1213, "y" : 1201, "width" : 75, "height" : 52 }, "textPosition" : { "x" : 1227, "y" : 1228 }, "connectors" : [ { "edgeId" : 15773, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1295, "y" : 1199 }, "b" : { "x" : 1288, "y" : 1203 }, "c" : { "x" : 1295, "y" : 1207 }, "type" : "ARROW", "centre" : { "x" : 1295, "y" : 1207 } } }, { "id" : 16062, "reactomeId" : 9850852, "displayName" : "ZAP70 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1825, "y" : 1702 }, "minX" : 1786, "maxX" : 1872, "minY" : 1674, "maxY" : 1728, "prop" : { "x" : 1786, "y" : 1676, "width" : 79, "height" : 52 }, "textPosition" : { "x" : 1799, "y" : 1703 }, "connectors" : [ { "edgeId" : 16061, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1872, "y" : 1674 }, "b" : { "x" : 1865, "y" : 1678 }, "c" : { "x" : 1872, "y" : 1682 }, "type" : "ARROW", "centre" : { "x" : 1872, "y" : 1682 } } }, { "id" : 191, "reactomeId" : 5673001, "displayName" : "RAF/MAP kinase cascade", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2124, "y" : 375 }, "minX" : 2062, "maxX" : 2187, "minY" : 346, "maxY" : 404, "prop" : { "x" : 2062, "y" : 346, "width" : 125, "height" : 58 }, "textPosition" : { "x" : 2065, "y" : 353 }, "connectors" : [ ] }, { "id" : 16063, "reactomeId" : 202397, "displayName" : "ZAP70", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1949, "y" : 1624 }, "minX" : 1926, "maxX" : 1979, "minY" : 1607, "maxY" : 1636, "prop" : { "x" : 1926, "y" : 1613, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 1929, "y" : 1607 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1973, "y" : 1613 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1973, "y" : 1613 } } }, "connectors" : [ { "edgeId" : 16061, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14015, "reactomeId" : 9701465, "displayName" : "AcK685- p-Y705,S727-STAT3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1956, "y" : 1479 }, "minX" : 1854, "maxX" : 2267, "minY" : 1360, "maxY" : 1868, "prop" : { "x" : 1895, "y" : 1461, "width" : 122, "height" : 37 }, "textPosition" : { "x" : 1895, "y" : 1463 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2017, "y" : 1461 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2017, "y" : 1461 } } }, "connectors" : [ { "edgeId" : 14088, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1898, "y" : 1501 }, "to" : { "x" : 1854, "y" : 1512 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1892, "y" : 1507 }, "b" : { "x" : 1898, "y" : 1501 }, "c" : { "x" : 1890, "y" : 1499 }, "type" : "ARROW", "centre" : { "x" : 1890, "y" : 1499 } } }, { "edgeId" : 14089, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1923, "y" : 1458 }, "to" : { "x" : 1873, "y" : 1432 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15883, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1966, "y" : 1501 }, "to" : { "x" : 2186, "y" : 1868 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14091, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1977, "y" : 1458 }, "to" : { "x" : 2096, "y" : 1360 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15998, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2020, "y" : 1470 }, "to" : { "x" : 2267, "y" : 1436 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 16003, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2008, "y" : 1501 }, "to" : { "x" : 2238, "y" : 1578 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 16020, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1971, "y" : 1501 }, "to" : { "x" : 2248, "y" : 1826 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15551, "reactomeId" : 452357, "displayName" : "MYCN", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1358, "y" : 1204 }, "isFadeOut" : true, "minX" : 1337, "maxX" : 1380, "minY" : 1193, "maxY" : 1216, "prop" : { "x" : 1337, "y" : 1193, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 1337, "y" : 1194 }, "connectors" : [ { "edgeId" : 15773, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14016, "reactomeId" : 351657, "displayName" : "SIN3A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2061, "y" : 1426 }, "isFadeOut" : true, "minX" : 2040, "maxX" : 2267, "minY" : 1360, "maxY" : 1438, "prop" : { "x" : 2040, "y" : 1415, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 2043, "y" : 1409 }, "connectors" : [ { "edgeId" : 14091, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2067, "y" : 1412 }, "to" : { "x" : 2096, "y" : 1360 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15998, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2086, "y" : 1427 }, "to" : { "x" : 2267, "y" : 1436 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14017, "reactomeId" : 6804192, "displayName" : "PRDM1 Gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1996, "y" : 1327 }, "isFadeOut" : true, "minX" : 1954, "maxX" : 2096, "minY" : 1299, "maxY" : 1360, "prop" : { "x" : 1954, "y" : 1301, "width" : 85, "height" : 52 }, "textPosition" : { "x" : 1969, "y" : 1328 }, "connectors" : [ { "edgeId" : 14091, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2048, "y" : 1303 }, "to" : { "x" : 2096, "y" : 1360 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14092, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 2046, "y" : 1299 }, "b" : { "x" : 2039, "y" : 1303 }, "c" : { "x" : 2046, "y" : 1307 }, "type" : "ARROW", "centre" : { "x" : 2046, "y" : 1307 } } }, { "id" : 14018, "reactomeId" : 9701467, "displayName" : "SIN3A:AcK685,p-Y705,p-S727 STAT3 dimer:PRDM1 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2255, "y" : 1388 }, "isFadeOut" : true, "minX" : 2188, "maxX" : 2323, "minY" : 1321, "maxY" : 1414, "prop" : { "x" : 2188, "y" : 1363, "width" : 135, "height" : 51 }, "textPosition" : { "x" : 2189, "y" : 1365 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 14091, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14092, "type" : "INHIBITOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2241, "y" : 1360 }, "to" : { "x" : 2220, "y" : 1323 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2217, "y" : 1325 }, "b" : { "x" : 2223, "y" : 1321 }, "c" : { "x" : 2220, "y" : 1323 }, "type" : "STOP", "centre" : { "x" : 2220, "y" : 1323 } } } ] }, { "id" : 14020, "reactomeId" : 6804199, "displayName" : "PRDM1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2343, "y" : 1324 }, "isFadeOut" : true, "minX" : 2318, "maxX" : 2369, "minY" : 1313, "maxY" : 1336, "prop" : { "x" : 2318, "y" : 1313, "width" : 51, "height" : 23 }, "textPosition" : { "x" : 2318, "y" : 1314 }, "connectors" : [ { "edgeId" : 14092, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14034, "reactomeId" : 113560, "displayName" : "Ac-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1754, "y" : 1542 }, "isFadeOut" : true, "minX" : 1724, "maxX" : 1785, "minY" : 1512, "maxY" : 1558, "prop" : { "x" : 1724, "y" : 1527, "width" : 61, "height" : 31 }, "textPosition" : { "x" : 1729, "y" : 1532 }, "connectors" : [ { "edgeId" : 14088, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1757, "y" : 1524 }, "to" : { "x" : 1761, "y" : 1512 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14035, "reactomeId" : 2485002, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1907, "y" : 1558 }, "isFadeOut" : true, "minX" : 1854, "maxX" : 1938, "minY" : 1512, "maxY" : 1574, "prop" : { "x" : 1876, "y" : 1543, "width" : 62, "height" : 31 }, "textPosition" : { "x" : 1880, "y" : 1548 }, "connectors" : [ { "edgeId" : 14088, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1889, "y" : 1540 }, "to" : { "x" : 1854, "y" : 1512 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1881, "y" : 1539 }, "b" : { "x" : 1889, "y" : 1540 }, "c" : { "x" : 1886, "y" : 1533 }, "type" : "ARROW", "centre" : { "x" : 1886, "y" : 1533 } } } ] }, { "id" : 14036, "reactomeId" : 381325, "displayName" : "EP300", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1821, "y" : 1477 }, "isFadeOut" : true, "minX" : 1798, "maxX" : 1845, "minY" : 1466, "maxY" : 1505, "prop" : { "x" : 1798, "y" : 1466, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 1801, "y" : 1460 }, "connectors" : [ { "edgeId" : 14088, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1820, "y" : 1492 }, "to" : { "x" : 1820, "y" : 1497 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1820, "y" : 1501 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1820, "y" : 1501 } } } ] }, { "id" : 221, "reactomeId" : 190244, "displayName" : "FRS2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1375, "y" : 273 }, "isFadeOut" : true, "minX" : 1357, "maxX" : 1401, "minY" : 199, "maxY" : 285, "prop" : { "x" : 1357, "y" : 262, "width" : 37, "height" : 23 }, "textPosition" : { "x" : 1360, "y" : 256 }, "connectors" : [ { "edgeId" : 220, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1379, "y" : 259 }, "to" : { "x" : 1401, "y" : 199 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 222, "reactomeId" : 9700006, "displayName" : "Active ALK:FRS2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1501, "y" : 194 }, "isFadeOut" : true, "minX" : 1451, "maxX" : 1672, "minY" : 154, "maxY" : 206, "prop" : { "x" : 1451, "y" : 183, "width" : 101, "height" : 23 }, "textPosition" : { "x" : 1464, "y" : 171 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 220, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 226, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1555, "y" : 195 }, "to" : { "x" : 1600, "y" : 196 } }, { "from" : { "x" : 1600, "y" : 196 }, "to" : { "x" : 1640, "y" : 196 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 226, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1540, "y" : 180 }, "to" : { "x" : 1640, "y" : 154 } }, { "from" : { "x" : 1640, "y" : 154 }, "to" : { "x" : 1666, "y" : 184 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1668, "y" : 187 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1668, "y" : 187 } } } ] }, { "id" : 14562, "reactomeId" : 74787, "displayName" : "PIK3CA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 545, "y" : 436 }, "minX" : 505, "maxX" : 577, "minY" : 419, "maxY" : 473, "prop" : { "x" : 520, "y" : 425, "width" : 51, "height" : 23 }, "textPosition" : { "x" : 520, "y" : 426 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 571, "y" : 425 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 571, "y" : 425 } } }, "connectors" : [ { "edgeId" : 14561, "type" : "INPUT", "segments" : [ { "from" : { "x" : 532, "y" : 451 }, "to" : { "x" : 505, "y" : 473 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15587, "reactomeId" : 201502, "displayName" : "ALK", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 189, "y" : 1913 }, "isFadeOut" : true, "minX" : 174, "maxX" : 277, "minY" : 1902, "maxY" : 2023, "prop" : { "x" : 174, "y" : 1902, "width" : 31, "height" : 23 }, "textPosition" : { "x" : 175, "y" : 1903 }, "connectors" : [ { "edgeId" : 27, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 208, "y" : 1924 }, "to" : { "x" : 277, "y" : 1978 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 29, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 190, "y" : 1928 }, "to" : { "x" : 206, "y" : 2023 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 228, "reactomeId" : 9700002, "displayName" : "Active ALK:p-6Y FRS2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1771, "y" : 190 }, "isFadeOut" : true, "minX" : 1695, "maxX" : 1825, "minY" : 172, "maxY" : 209, "prop" : { "x" : 1718, "y" : 172, "width" : 107, "height" : 37 }, "textPosition" : { "x" : 1719, "y" : 174 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 226, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1715, "y" : 194 }, "to" : { "x" : 1695, "y" : 197 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1709, "y" : 199 }, "b" : { "x" : 1715, "y" : 194 }, "c" : { "x" : 1708, "y" : 191 }, "type" : "ARROW", "centre" : { "x" : 1708, "y" : 191 } } } ] }, { "id" : 14564, "reactomeId" : 9711926, "displayName" : "PI3K-binding ALK fusions:PI3K", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 392, "y" : 482 }, "isDisease" : true, "minX" : 303, "maxX" : 456, "minY" : 458, "maxY" : 501, "prop" : { "x" : 335, "y" : 464, "width" : 115, "height" : 37 }, "textPosition" : { "x" : 336, "y" : 466 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 450, "y" : 464 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 450, "y" : 464 } } }, "connectors" : [ { "edgeId" : 14561, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14574, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 332, "y" : 485 }, "to" : { "x" : 311, "y" : 487 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 307, "y" : 487 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 307, "y" : 487 } }, "isDisease" : true } ] }, { "id" : 14566, "reactomeId" : 74789, "displayName" : "PIK3R1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 943, "y" : 438 }, "minX" : 864, "maxX" : 975, "minY" : 421, "maxY" : 458, "prop" : { "x" : 918, "y" : 427, "width" : 51, "height" : 23 }, "textPosition" : { "x" : 918, "y" : 428 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 969, "y" : 427 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 969, "y" : 427 } } }, "connectors" : [ { "edgeId" : 14565, "type" : "INPUT", "segments" : [ { "from" : { "x" : 915, "y" : 444 }, "to" : { "x" : 864, "y" : 458 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14054, "reactomeId" : 427486, "displayName" : "CH3COO-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1737, "y" : 1390 }, "isFadeOut" : true, "minX" : 1700, "maxX" : 1787, "minY" : 1375, "maxY" : 1430, "prop" : { "x" : 1700, "y" : 1375, "width" : 75, "height" : 31 }, "textPosition" : { "x" : 1706, "y" : 1380 }, "connectors" : [ { "edgeId" : 14089, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1756, "y" : 1409 }, "to" : { "x" : 1787, "y" : 1430 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1764, "y" : 1410 }, "b" : { "x" : 1756, "y" : 1409 }, "c" : { "x" : 1759, "y" : 1416 }, "type" : "ARROW", "centre" : { "x" : 1759, "y" : 1416 } } } ] }, { "id" : 14567, "reactomeId" : 9711929, "displayName" : "PI3K-binding ALK mutants", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 913, "y" : 515 }, "isDisease" : true, "minX" : 856, "maxX" : 971, "minY" : 458, "maxY" : 534, "prop" : { "x" : 856, "y" : 497, "width" : 115, "height" : 37 }, "textPosition" : { "x" : 857, "y" : 498 }, "connectors" : [ { "edgeId" : 14565, "type" : "INPUT", "segments" : [ { "from" : { "x" : 897, "y" : 491 }, "to" : { "x" : 864, "y" : 458 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14570, "reactomeId" : 9711928, "displayName" : "ALK mutants:PIK3R1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 757, "y" : 465 }, "isDisease" : true, "minX" : 505, "maxX" : 827, "minY" : 448, "maxY" : 477, "prop" : { "x" : 694, "y" : 454, "width" : 127, "height" : 23 }, "textPosition" : { "x" : 713, "y" : 442 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 821, "y" : 454 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 821, "y" : 454 } } }, "connectors" : [ { "edgeId" : 14561, "type" : "INPUT", "segments" : [ { "from" : { "x" : 691, "y" : 467 }, "to" : { "x" : 505, "y" : 473 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14565, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 16618, "reactomeId" : 198644, "displayName" : "MDM2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 601, "y" : 2843 }, "minX" : 578, "maxX" : 630, "minY" : 2822, "maxY" : 2855, "prop" : { "x" : 578, "y" : 2832, "width" : 46, "height" : 23 }, "textPosition" : { "x" : 578, "y" : 2833 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 624, "y" : 2832 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 624, "y" : 2832 } } }, "connectors" : [ { "edgeId" : 16617, "type" : "INPUT", "segments" : [ { "from" : { "x" : 616, "y" : 2829 }, "to" : { "x" : 630, "y" : 2822 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 16619, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 597, "y" : 2779 }, "minX" : 577, "maxX" : 630, "minY" : 2763, "maxY" : 2822, "prop" : { "x" : 577, "y" : 2764, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 581, "y" : 2769 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 612, "y" : 2769 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 612, "y" : 2769 } } }, "connectors" : [ { "edgeId" : 16617, "type" : "INPUT", "segments" : [ { "from" : { "x" : 608, "y" : 2798 }, "to" : { "x" : 630, "y" : 2822 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 613, "y" : 2804 }, "b" : { "x" : 625, "y" : 2816 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 619, "y" : 2810 } } }, "isDisease" : true } ] }, { "id" : 16620, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 726, "y" : 2774 }, "minX" : 679, "maxX" : 748, "minY" : 2758, "maxY" : 2823, "prop" : { "x" : 706, "y" : 2759, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 710, "y" : 2764 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 742, "y" : 2764 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 742, "y" : 2764 } } }, "connectors" : [ { "edgeId" : 16617, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 711, "y" : 2793 }, "to" : { "x" : 679, "y" : 2823 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 689, "y" : 2802 }, "b" : { "x" : 701, "y" : 2814 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 695, "y" : 2808 } } }, "endShape" : { "a" : { "x" : 709, "y" : 2801 }, "b" : { "x" : 711, "y" : 2793 }, "c" : { "x" : 703, "y" : 2795 }, "type" : "ARROW", "centre" : { "x" : 703, "y" : 2795 } }, "isDisease" : true } ] }, { "id" : 16621, "reactomeId" : 198638, "displayName" : "p-S166,S188-MDM2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 745, "y" : 2858 }, "minX" : 679, "maxX" : 803, "minY" : 2823, "maxY" : 2878, "prop" : { "x" : 694, "y" : 2838, "width" : 103, "height" : 40 }, "innerProp" : { "x" : 694, "y" : 2844, "width" : 103, "height" : 34 }, "textPosition" : { "x" : 699, "y" : 2840 }, "nodeAttachments" : [ { "reactomeId" : 2399939, "label" : "P", "description" : "O-phospho-L-serine at 166", "shape" : { "a" : { "x" : 705, "y" : 2832 }, "b" : { "x" : 717, "y" : 2844 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 711, "y" : 2838 } } }, { "reactomeId" : 2399935, "label" : "P", "description" : "O-phospho-L-serine at 188", "shape" : { "a" : { "x" : 723, "y" : 2832 }, "b" : { "x" : 735, "y" : 2844 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 729, "y" : 2838 } } } ], "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 797, "y" : 2838 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 797, "y" : 2838 } } }, "connectors" : [ { "edgeId" : 16617, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 707, "y" : 2835 }, "to" : { "x" : 679, "y" : 2823 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 699, "y" : 2836 }, "b" : { "x" : 707, "y" : 2835 }, "c" : { "x" : 702, "y" : 2829 }, "type" : "ARROW", "centre" : { "x" : 702, "y" : 2829 } }, "isDisease" : true } ] }, { "id" : 16622, "reactomeId" : 9850898, "displayName" : "NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer:PI3K", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 659, "y" : 2640 }, "isDisease" : true, "minX" : 594, "maxX" : 731, "minY" : 2609, "maxY" : 2814, "prop" : { "x" : 594, "y" : 2615, "width" : 131, "height" : 51 }, "textPosition" : { "x" : 597, "y" : 2617 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 725, "y" : 2615 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 725, "y" : 2615 } } }, "connectors" : [ { "edgeId" : 16617, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 658, "y" : 2669 }, "to" : { "x" : 657, "y" : 2814 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 653, "y" : 2807 }, "b" : { "x" : 657, "y" : 2814 }, "c" : { "x" : 661, "y" : 2807 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 661, "y" : 2807 } }, "isDisease" : true } ] }, { "id" : 14069, "reactomeId" : 9701417, "displayName" : "IL2RG gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 2144, "y" : 1498 }, "isFadeOut" : true, "minX" : 2107, "maxX" : 2267, "minY" : 1436, "maxY" : 1578, "prop" : { "x" : 2107, "y" : 1472, "width" : 75, "height" : 52 }, "textPosition" : { "x" : 2121, "y" : 1499 }, "connectors" : [ { "edgeId" : 14094, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15998, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2191, "y" : 1474 }, "to" : { "x" : 2267, "y" : 1436 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 16003, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2191, "y" : 1474 }, "to" : { "x" : 2238, "y" : 1578 } } ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 2189, "y" : 1470 }, "b" : { "x" : 2182, "y" : 1474 }, "c" : { "x" : 2189, "y" : 1478 }, "type" : "ARROW", "centre" : { "x" : 2189, "y" : 1478 } } }, { "id" : 14070, "reactomeId" : 9701471, "displayName" : "SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2531, "y" : 1435 }, "isFadeOut" : true, "minX" : 2471, "maxX" : 2591, "minY" : 1410, "maxY" : 1491, "prop" : { "x" : 2471, "y" : 1410, "width" : 120, "height" : 51 }, "textPosition" : { "x" : 2471, "y" : 1412 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 14094, "type" : "INHIBITOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2533, "y" : 1464 }, "to" : { "x" : 2537, "y" : 1490 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2533, "y" : 1491 }, "b" : { "x" : 2541, "y" : 1489 }, "c" : { "x" : 2537, "y" : 1490 }, "type" : "STOP", "centre" : { "x" : 2537, "y" : 1490 } } }, { "edgeId" : 15998, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 16121, "reactomeId" : 2976052, "displayName" : "GZMB Gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 2341, "y" : 2790 }, "minX" : 2303, "maxX" : 2388, "minY" : 2695, "maxY" : 2816, "prop" : { "x" : 2303, "y" : 2764, "width" : 76, "height" : 52 }, "textPosition" : { "x" : 2317, "y" : 2791 }, "connectors" : [ { "edgeId" : 16120, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2388, "y" : 2766 }, "to" : { "x" : 2308, "y" : 2695 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 16123, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 2386, "y" : 2762 }, "b" : { "x" : 2379, "y" : 2766 }, "c" : { "x" : 2386, "y" : 2770 }, "type" : "ARROW", "centre" : { "x" : 2386, "y" : 2770 } } }, { "id" : 16122, "reactomeId" : 9850873, "displayName" : "GZMB gene:JUNB dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2174, "y" : 2698 }, "minX" : 2119, "maxX" : 2235, "minY" : 2674, "maxY" : 2786, "prop" : { "x" : 2119, "y" : 2680, "width" : 110, "height" : 37 }, "textPosition" : { "x" : 2132, "y" : 2682 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2229, "y" : 2680 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2229, "y" : 2680 } } }, "connectors" : [ { "edgeId" : 16120, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 16123, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 2174, "y" : 2720 }, "to" : { "x" : 2178, "y" : 2786 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2174, "y" : 2779 }, "b" : { "x" : 2178, "y" : 2786 }, "c" : { "x" : 2182, "y" : 2779 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2182, "y" : 2779 } }, "isDisease" : true } ] }, { "id" : 16124, "reactomeId" : 6807037, "displayName" : "GZMB", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2182, "y" : 3183 }, "minX" : 2161, "maxX" : 2209, "minY" : 3166, "maxY" : 3195, "prop" : { "x" : 2161, "y" : 3172, "width" : 42, "height" : 23 }, "textPosition" : { "x" : 2164, "y" : 3166 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2203, "y" : 3172 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2203, "y" : 3172 } } }, "connectors" : [ { "edgeId" : 16123, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14078, "reactomeId" : 449139, "displayName" : "IL2RG", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2981, "y" : 1494 }, "isFadeOut" : true, "minX" : 2960, "maxX" : 3003, "minY" : 1483, "maxY" : 1506, "prop" : { "x" : 2960, "y" : 1483, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 2960, "y" : 1484 }, "connectors" : [ { "edgeId" : 14094, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 16127, "reactomeId" : 9850855, "displayName" : "PRF1 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1901, "y" : 2800 }, "minX" : 1866, "maxX" : 1943, "minY" : 2772, "maxY" : 2826, "prop" : { "x" : 1866, "y" : 2774, "width" : 70, "height" : 52 }, "textPosition" : { "x" : 1879, "y" : 2801 }, "connectors" : [ { "edgeId" : 16126, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1943, "y" : 2772 }, "b" : { "x" : 1936, "y" : 2776 }, "c" : { "x" : 1943, "y" : 2780 }, "type" : "ARROW", "centre" : { "x" : 1943, "y" : 2780 } } }, { "id" : 16128, "reactomeId" : 9850839, "displayName" : "PRF1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2131, "y" : 3188 }, "minX" : 2112, "maxX" : 2156, "minY" : 3171, "maxY" : 3200, "prop" : { "x" : 2112, "y" : 3177, "width" : 38, "height" : 23 }, "textPosition" : { "x" : 2115, "y" : 3171 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2150, "y" : 3177 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2150, "y" : 3177 } } }, "connectors" : [ { "edgeId" : 16126, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14083, "reactomeId" : 8948427, "displayName" : "HIF1A gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1552, "y" : 1329 }, "isFadeOut" : true, "minX" : 1460, "maxX" : 1599, "minY" : 1285, "maxY" : 1381, "prop" : { "x" : 1515, "y" : 1303, "width" : 75, "height" : 52 }, "textPosition" : { "x" : 1529, "y" : 1330 }, "connectors" : [ { "edgeId" : 14095, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1599, "y" : 1305 }, "to" : { "x" : 1540, "y" : 1285 } }, { "from" : { "x" : 1540, "y" : 1285 }, "to" : { "x" : 1492, "y" : 1288 } }, { "from" : { "x" : 1492, "y" : 1288 }, "to" : { "x" : 1460, "y" : 1381 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14096, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1597, "y" : 1301 }, "b" : { "x" : 1590, "y" : 1305 }, "c" : { "x" : 1597, "y" : 1309 }, "type" : "ARROW", "centre" : { "x" : 1597, "y" : 1309 } } }, { "id" : 14084, "reactomeId" : 9701459, "displayName" : "p-Y705, S727 STAT3 dimer:HIF1A gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1515, "y" : 1172 }, "isFadeOut" : true, "minX" : 1452, "maxX" : 1632, "minY" : 1147, "maxY" : 1308, "prop" : { "x" : 1452, "y" : 1147, "width" : 127, "height" : 51 }, "textPosition" : { "x" : 1452, "y" : 1149 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 14095, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14096, "type" : "ACTIVATOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1566, "y" : 1201 }, "to" : { "x" : 1621, "y" : 1225 } }, { "from" : { "x" : 1621, "y" : 1225 }, "to" : { "x" : 1629, "y" : 1308 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1624, "y" : 1301 }, "b" : { "x" : 1629, "y" : 1308 }, "c" : { "x" : 1632, "y" : 1301 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1632, "y" : 1301 } } } ] }, { "id" : 15622, "reactomeId" : 9699986, "displayName" : "PTN,MDK", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 119, "y" : 1996 }, "isFadeOut" : true, "minX" : 87, "maxX" : 151, "minY" : 1985, "maxY" : 2240, "prop" : { "x" : 87, "y" : 1985, "width" : 64, "height" : 23 }, "textPosition" : { "x" : 88, "y" : 1986 }, "connectors" : [ { "edgeId" : 15621, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 118, "y" : 2014 }, "to" : { "x" : 113, "y" : 2240 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14086, "reactomeId" : 1234135, "displayName" : "HIF1A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1680, "y" : 1318 }, "isFadeOut" : true, "minX" : 1659, "maxX" : 1702, "minY" : 1307, "maxY" : 1330, "prop" : { "x" : 1659, "y" : 1307, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 1659, "y" : 1308 }, "connectors" : [ { "edgeId" : 14096, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13575, "reactomeId" : 9700080, "displayName" : "ALK fusion proteins", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1338, "y" : 771 }, "isDisease" : true, "minX" : 1278, "maxX" : 1432, "minY" : 760, "maxY" : 783, "prop" : { "x" : 1278, "y" : 760, "width" : 120, "height" : 23 }, "textPosition" : { "x" : 1300, "y" : 754 }, "connectors" : [ { "edgeId" : 13574, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1420, "y" : 761 }, "b" : { "x" : 1432, "y" : 773 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1426, "y" : 767 } } }, "isDisease" : true } ] }, { "id" : 14087, "reactomeId" : 205005, "displayName" : "Histone deacetylase", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1832, "y" : 1347 }, "isFadeOut" : true, "minX" : 1770, "maxX" : 1894, "minY" : 1336, "maxY" : 1422, "prop" : { "x" : 1770, "y" : 1336, "width" : 124, "height" : 23 }, "textPosition" : { "x" : 1790, "y" : 1330 }, "connectors" : [ { "edgeId" : 14089, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1832, "y" : 1365 }, "to" : { "x" : 1834, "y" : 1414 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1834, "y" : 1418 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1834, "y" : 1418 } } } ] }, { "id" : 13576, "reactomeId" : 9700079, "displayName" : "ALK fusion protein dimers", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1532, "y" : 766 }, "isDisease" : true, "minX" : 1473, "maxX" : 1654, "minY" : 736, "maxY" : 785, "prop" : { "x" : 1473, "y" : 748, "width" : 118, "height" : 37 }, "textPosition" : { "x" : 1482, "y" : 749 }, "connectors" : [ { "edgeId" : 13574, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 13577, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1597, "y" : 764 }, "to" : { "x" : 1635, "y" : 763 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 13577, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1588, "y" : 742 }, "to" : { "x" : 1624, "y" : 736 } }, { "from" : { "x" : 1624, "y" : 736 }, "to" : { "x" : 1647, "y" : 753 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1650, "y" : 756 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1650, "y" : 756 } }, "isDisease" : true } ] }, { "id" : 14090, "reactomeId" : 113518, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1913, "y" : 1382 }, "isFadeOut" : true, "minX" : 1873, "maxX" : 1935, "minY" : 1367, "maxY" : 1432, "prop" : { "x" : 1892, "y" : 1367, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1896, "y" : 1372 }, "connectors" : [ { "edgeId" : 14089, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1900, "y" : 1401 }, "to" : { "x" : 1873, "y" : 1432 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13578, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1604, "y" : 805 }, "minX" : 1584, "maxX" : 1635, "minY" : 763, "maxY" : 821, "prop" : { "x" : 1584, "y" : 790, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1588, "y" : 795 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1619, "y" : 795 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1619, "y" : 795 } } }, "connectors" : [ { "edgeId" : 13577, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1615, "y" : 787 }, "to" : { "x" : 1635, "y" : 763 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1619, "y" : 769 }, "b" : { "x" : 1631, "y" : 781 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1625, "y" : 775 } } }, "isDisease" : true } ] }, { "id" : 14602, "reactomeId" : 191476, "displayName" : "FRS2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1569, "y" : 465 }, "minX" : 1545, "maxX" : 1606, "minY" : 454, "maxY" : 509, "prop" : { "x" : 1545, "y" : 454, "width" : 49, "height" : 23 }, "textPosition" : { "x" : 1548, "y" : 448 }, "connectors" : [ { "edgeId" : 14601, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1578, "y" : 483 }, "to" : { "x" : 1606, "y" : 509 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 13579, "reactomeId" : 9699980, "displayName" : "p-7Y ALK fusion protein dimers", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1765, "y" : 759 }, "isDisease" : true, "minX" : 1683, "maxX" : 1819, "minY" : 741, "maxY" : 778, "prop" : { "x" : 1712, "y" : 741, "width" : 107, "height" : 37 }, "textPosition" : { "x" : 1712, "y" : 742 }, "connectors" : [ { "edgeId" : 13577, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1706, "y" : 760 }, "to" : { "x" : 1683, "y" : 761 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1699, "y" : 764 }, "b" : { "x" : 1706, "y" : 760 }, "c" : { "x" : 1699, "y" : 756 }, "type" : "ARROW", "centre" : { "x" : 1699, "y" : 756 } }, "isDisease" : true } ] }, { "id" : 13580, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1714, "y" : 823 }, "minX" : 1683, "maxX" : 1736, "minY" : 761, "maxY" : 839, "prop" : { "x" : 1694, "y" : 808, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1698, "y" : 813 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1730, "y" : 813 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1730, "y" : 813 } } }, "connectors" : [ { "edgeId" : 13577, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1706, "y" : 805 }, "to" : { "x" : 1683, "y" : 761 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1688, "y" : 777 }, "b" : { "x" : 1700, "y" : 789 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1694, "y" : 783 } } }, "endShape" : { "a" : { "x" : 1699, "y" : 801 }, "b" : { "x" : 1706, "y" : 805 }, "c" : { "x" : 1706, "y" : 797 }, "type" : "ARROW", "centre" : { "x" : 1706, "y" : 797 } }, "isDisease" : true } ] }, { "id" : 15631, "reactomeId" : 9845024, "displayName" : "ICOS gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 2190, "y" : 2277 }, "minX" : 1972, "maxX" : 2233, "minY" : 2233, "maxY" : 2303, "prop" : { "x" : 2157, "y" : 2251, "width" : 67, "height" : 52 }, "textPosition" : { "x" : 2170, "y" : 2278 }, "connectors" : [ { "edgeId" : 15653, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15674, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2233, "y" : 2253 }, "to" : { "x" : 1972, "y" : 2233 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 2231, "y" : 2249 }, "b" : { "x" : 2224, "y" : 2253 }, "c" : { "x" : 2231, "y" : 2257 }, "type" : "ARROW", "centre" : { "x" : 2231, "y" : 2257 } } }, { "id" : 14607, "reactomeId" : 9711938, "displayName" : "ALK fusions:FRS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1758, "y" : 513 }, "isDisease" : true, "minX" : 1709, "maxX" : 1861, "minY" : 496, "maxY" : 546, "prop" : { "x" : 1709, "y" : 502, "width" : 99, "height" : 23 }, "textPosition" : { "x" : 1717, "y" : 490 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1808, "y" : 502 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1808, "y" : 502 } } }, "connectors" : [ { "edgeId" : 14601, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14608, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1811, "y" : 514 }, "to" : { "x" : 1843, "y" : 515 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14608, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1789, "y" : 528 }, "to" : { "x" : 1849, "y" : 546 } }, { "from" : { "x" : 1849, "y" : 546 }, "to" : { "x" : 1855, "y" : 529 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1857, "y" : 525 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1857, "y" : 525 } }, "isDisease" : true } ] }, { "id" : 15632, "reactomeId" : 9850889, "displayName" : "ICOS gene:p-STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2226, "y" : 2145 }, "isDisease" : true, "minX" : 2164, "maxX" : 2414, "minY" : 2128, "maxY" : 2235, "prop" : { "x" : 2164, "y" : 2134, "width" : 124, "height" : 23 }, "textPosition" : { "x" : 2182, "y" : 2122 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2288, "y" : 2134 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2288, "y" : 2134 } } }, "connectors" : [ { "edgeId" : 15653, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 2250, "y" : 2160 }, "to" : { "x" : 2414, "y" : 2234 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2406, "y" : 2235 }, "b" : { "x" : 2414, "y" : 2234 }, "c" : { "x" : 2409, "y" : 2228 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2409, "y" : 2228 } }, "isDisease" : true }, { "edgeId" : 15674, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14098, "reactomeId" : 9701419, "displayName" : "CD274 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1943, "y" : 1253 }, "isFadeOut" : true, "minX" : 1902, "maxX" : 2031, "minY" : 1183, "maxY" : 1279, "prop" : { "x" : 1902, "y" : 1227, "width" : 82, "height" : 52 }, "textPosition" : { "x" : 1916, "y" : 1254 }, "connectors" : [ { "edgeId" : 14097, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1993, "y" : 1229 }, "to" : { "x" : 2031, "y" : 1183 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14100, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1991, "y" : 1225 }, "b" : { "x" : 1984, "y" : 1229 }, "c" : { "x" : 1991, "y" : 1233 }, "type" : "ARROW", "centre" : { "x" : 1991, "y" : 1233 } } }, { "id" : 16659, "reactomeId" : 3222171, "displayName" : "p-S15,S20-TP53 Tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1572, "y" : 2723 }, "minX" : 1522, "maxX" : 1629, "minY" : 2698, "maxY" : 2807, "prop" : { "x" : 1522, "y" : 2704, "width" : 101, "height" : 39 }, "textPosition" : { "x" : 1522, "y" : 2708 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1623, "y" : 2704 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1623, "y" : 2704 } } }, "connectors" : [ { "edgeId" : 17163, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 16682, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1577, "y" : 2746 }, "to" : { "x" : 1595, "y" : 2807 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14099, "reactomeId" : 9701462, "displayName" : "p-Y705, S727 STAT3 dimer:CD274 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2222, "y" : 1178 }, "isFadeOut" : true, "minX" : 2155, "maxX" : 2289, "minY" : 1153, "maxY" : 1235, "prop" : { "x" : 2155, "y" : 1153, "width" : 134, "height" : 51 }, "textPosition" : { "x" : 2154, "y" : 1169 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 14097, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14100, "type" : "ACTIVATOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2225, "y" : 1207 }, "to" : { "x" : 2229, "y" : 1235 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2224, "y" : 1229 }, "b" : { "x" : 2229, "y" : 1235 }, "c" : { "x" : 2232, "y" : 1228 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2232, "y" : 1228 } } } ] }, { "id" : 14611, "reactomeId" : 9712069, "displayName" : "ALK fusions:p-6Y FRS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2009, "y" : 514 }, "isDisease" : true, "minX" : 1877, "maxX" : 2072, "minY" : 490, "maxY" : 533, "prop" : { "x" : 1953, "y" : 496, "width" : 113, "height" : 37 }, "textPosition" : { "x" : 1953, "y" : 498 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2066, "y" : 496 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2066, "y" : 496 } } }, "connectors" : [ { "edgeId" : 14608, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1950, "y" : 513 }, "to" : { "x" : 1877, "y" : 512 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1943, "y" : 517 }, "b" : { "x" : 1950, "y" : 513 }, "c" : { "x" : 1943, "y" : 509 }, "type" : "ARROW", "centre" : { "x" : 1943, "y" : 509 } }, "isDisease" : true } ] }, { "id" : 13588, "reactomeId" : 9700015, "displayName" : "ALK mutant dimers:SHC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1785, "y" : 635 }, "isDisease" : true, "minX" : 1724, "maxX" : 1890, "minY" : 591, "maxY" : 654, "prop" : { "x" : 1724, "y" : 617, "width" : 123, "height" : 37 }, "textPosition" : { "x" : 1742, "y" : 619 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1847, "y" : 617 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1847, "y" : 617 } } }, "connectors" : [ { "edgeId" : 13587, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 13589, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1850, "y" : 633 }, "to" : { "x" : 1873, "y" : 633 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 13589, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1820, "y" : 614 }, "to" : { "x" : 1870, "y" : 591 } }, { "from" : { "x" : 1870, "y" : 591 }, "to" : { "x" : 1884, "y" : 618 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1886, "y" : 621 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1886, "y" : 621 } }, "isDisease" : true } ] }, { "id" : 14101, "reactomeId" : 3211776, "displayName" : "CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2980, "y" : 1247 }, "isFadeOut" : true, "minX" : 2955, "maxX" : 3005, "minY" : 1236, "maxY" : 1259, "prop" : { "x" : 2955, "y" : 1236, "width" : 50, "height" : 23 }, "textPosition" : { "x" : 2955, "y" : 1237 }, "connectors" : [ { "edgeId" : 14100, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13590, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1844, "y" : 686 }, "minX" : 1824, "maxX" : 1873, "minY" : 633, "maxY" : 702, "prop" : { "x" : 1824, "y" : 671, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1828, "y" : 676 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1859, "y" : 676 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1859, "y" : 676 } } }, "connectors" : [ { "edgeId" : 13589, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1852, "y" : 668 }, "to" : { "x" : 1873, "y" : 633 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1856, "y" : 644 }, "b" : { "x" : 1868, "y" : 656 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1862, "y" : 650 } } }, "isDisease" : true } ] }, { "id" : 13591, "reactomeId" : 9699971, "displayName" : "ALK fusion dimers:p-3Y SHC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1992, "y" : 620 }, "isDisease" : true, "minX" : 1909, "maxX" : 2057, "minY" : 596, "maxY" : 956, "prop" : { "x" : 1934, "y" : 602, "width" : 117, "height" : 37 }, "textPosition" : { "x" : 1950, "y" : 590 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2051, "y" : 602 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2051, "y" : 602 } } }, "connectors" : [ { "edgeId" : 13589, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1931, "y" : 623 }, "to" : { "x" : 1909, "y" : 625 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1924, "y" : 628 }, "b" : { "x" : 1931, "y" : 623 }, "c" : { "x" : 1924, "y" : 620 }, "type" : "ARROW", "centre" : { "x" : 1924, "y" : 620 } }, "isDisease" : true }, { "edgeId" : 14925, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1991, "y" : 642 }, "to" : { "x" : 1979, "y" : 956 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 16664, "reactomeId" : 9850930, "displayName" : "p-T,Y MAPK8,9:TP53 tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1703, "y" : 2804 }, "minX" : 1651, "maxX" : 1761, "minY" : 2732, "maxY" : 2823, "prop" : { "x" : 1651, "y" : 2786, "width" : 104, "height" : 37 }, "textPosition" : { "x" : 1653, "y" : 2788 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1755, "y" : 2786 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1755, "y" : 2786 } } }, "connectors" : [ { "edgeId" : 17163, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1696, "y" : 2783 }, "to" : { "x" : 1678, "y" : 2732 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1684, "y" : 2737 }, "b" : { "x" : 1678, "y" : 2732 }, "c" : { "x" : 1677, "y" : 2740 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1677, "y" : 2740 } }, "isDisease" : true }, { "edgeId" : 16682, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 13592, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1942, "y" : 680 }, "minX" : 1909, "maxX" : 1964, "minY" : 625, "maxY" : 696, "prop" : { "x" : 1922, "y" : 665, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1926, "y" : 670 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1958, "y" : 670 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1958, "y" : 670 } } }, "connectors" : [ { "edgeId" : 13589, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1932, "y" : 662 }, "to" : { "x" : 1909, "y" : 625 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1914, "y" : 637 }, "b" : { "x" : 1926, "y" : 649 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1920, "y" : 643 } } }, "endShape" : { "a" : { "x" : 1925, "y" : 658 }, "b" : { "x" : 1932, "y" : 662 }, "c" : { "x" : 1932, "y" : 654 }, "type" : "ARROW", "centre" : { "x" : 1932, "y" : 654 } }, "isDisease" : true } ] }, { "id" : 17177, "reactomeId" : 68642, "displayName" : "RB1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1270, "y" : 2336 }, "minX" : 1254, "maxX" : 1292, "minY" : 2319, "maxY" : 2348, "prop" : { "x" : 1254, "y" : 2325, "width" : 32, "height" : 23 }, "textPosition" : { "x" : 1254, "y" : 2326 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1286, "y" : 2325 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1286, "y" : 2325 } } }, "connectors" : [ { "edgeId" : 17176, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 17178, "reactomeId" : 188389, "displayName" : "hyperphosphorylated RB1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1462, "y" : 2331 }, "minX" : 1395, "maxX" : 1536, "minY" : 2305, "maxY" : 2358, "prop" : { "x" : 1395, "y" : 2311, "width" : 135, "height" : 41 }, "innerProp" : { "x" : 1395, "y" : 2317, "width" : 129, "height" : 29 }, "textPosition" : { "x" : 1396, "y" : 2314 }, "nodeAttachments" : [ { "reactomeId" : 69225, "label" : "P", "description" : "O-phospho-L-serine at 795", "shape" : { "a" : { "x" : 1405, "y" : 2305 }, "b" : { "x" : 1417, "y" : 2317 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1411, "y" : 2311 } } }, { "reactomeId" : 9687341, "label" : "P", "description" : "O-phospho-L-serine at 230", "shape" : { "a" : { "x" : 1421, "y" : 2305 }, "b" : { "x" : 1433, "y" : 2317 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1427, "y" : 2311 } } }, { "reactomeId" : 9687344, "label" : "P", "description" : "O-phospho-L-serine at 249", "shape" : { "a" : { "x" : 1437, "y" : 2305 }, "b" : { "x" : 1449, "y" : 2317 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1443, "y" : 2311 } } }, { "reactomeId" : 9687333, "label" : "P", "description" : "O-phospho-L-threonine at 252", "shape" : { "a" : { "x" : 1453, "y" : 2305 }, "b" : { "x" : 1465, "y" : 2317 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1459, "y" : 2311 } } }, { "reactomeId" : 9687337, "label" : "P", "description" : "O-phospho-L-serine at 608", "shape" : { "a" : { "x" : 1469, "y" : 2305 }, "b" : { "x" : 1481, "y" : 2317 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1475, "y" : 2311 } } }, { "reactomeId" : 9687359, "label" : "P", "description" : "O-phospho-L-serine at 612", "shape" : { "a" : { "x" : 1485, "y" : 2305 }, "b" : { "x" : 1497, "y" : 2317 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1491, "y" : 2311 } } }, { "reactomeId" : 9687345, "label" : "P", "description" : "O-phospho-L-serine at 780", "shape" : { "a" : { "x" : 1501, "y" : 2305 }, "b" : { "x" : 1513, "y" : 2317 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1507, "y" : 2311 } } }, { "reactomeId" : 9687338, "label" : "P", "description" : "O-phospho-L-serine at 788", "shape" : { "a" : { "x" : 1524, "y" : 2321 }, "b" : { "x" : 1536, "y" : 2333 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1530, "y" : 2327 } } }, { "reactomeId" : 9687346, "label" : "P", "description" : "O-phospho-L-serine at 807", "shape" : { "a" : { "x" : 1508, "y" : 2346 }, "b" : { "x" : 1520, "y" : 2358 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1514, "y" : 2352 } } }, { "reactomeId" : 9687358, "label" : "P", "description" : "O-phospho-L-serine at 811", "shape" : { "a" : { "x" : 1492, "y" : 2346 }, "b" : { "x" : 1504, "y" : 2358 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1498, "y" : 2352 } } }, { "reactomeId" : 9687342, "label" : "P", "description" : "O-phospho-L-threonine at 356", "shape" : { "a" : { "x" : 1476, "y" : 2346 }, "b" : { "x" : 1488, "y" : 2358 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1482, "y" : 2352 } } }, { "reactomeId" : 9687360, "label" : "P", "description" : "O-phospho-L-threonine at 373", "shape" : { "a" : { "x" : 1460, "y" : 2346 }, "b" : { "x" : 1472, "y" : 2358 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1466, "y" : 2352 } } }, { "reactomeId" : 9687350, "label" : "P", "description" : "O-phospho-L-threonine at 821", "shape" : { "a" : { "x" : 1444, "y" : 2346 }, "b" : { "x" : 1456, "y" : 2358 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1450, "y" : 2352 } } }, { "reactomeId" : 9687349, "label" : "P", "description" : "O-phospho-L-threonine at 826", "shape" : { "a" : { "x" : 1428, "y" : 2346 }, "b" : { "x" : 1440, "y" : 2358 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1434, "y" : 2352 } } } ], "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1530, "y" : 2311 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1530, "y" : 2311 } } }, "connectors" : [ { "edgeId" : 17176, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15654, "reactomeId" : 9850886, "displayName" : "ICOS dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2984, "y" : 2266 }, "minX" : 2948, "maxX" : 3027, "minY" : 2249, "maxY" : 2278, "prop" : { "x" : 2948, "y" : 2255, "width" : 73, "height" : 23 }, "textPosition" : { "x" : 2963, "y" : 2243 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3021, "y" : 2255 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3021, "y" : 2255 } } }, "connectors" : [ { "edgeId" : 15653, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 296, "reactomeId" : 74693, "displayName" : "PI3K", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 806, "y" : 346 }, "isFadeOut" : true, "minX" : 712, "maxX" : 824, "minY" : 335, "maxY" : 358, "prop" : { "x" : 789, "y" : 335, "width" : 35, "height" : 23 }, "textPosition" : { "x" : 789, "y" : 337 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 295, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 786, "y" : 344 }, "to" : { "x" : 712, "y" : 337 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 297, "reactomeId" : 9699995, "displayName" : "Active ALK:PI3K", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 212, "y" : 338 }, "isFadeOut" : true, "minX" : 163, "maxX" : 261, "minY" : 327, "maxY" : 488, "prop" : { "x" : 163, "y" : 327, "width" : 98, "height" : 23 }, "textPosition" : { "x" : 175, "y" : 315 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 295, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 307, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 207, "y" : 353 }, "to" : { "x" : 170, "y" : 457 } }, { "from" : { "x" : 170, "y" : 457 }, "to" : { "x" : 232, "y" : 483 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 236, "y" : 484 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 236, "y" : 484 } } } ] }, { "id" : 13612, "reactomeId" : 9700567, "displayName" : "ALK point mutants", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 342, "y" : 71 }, "isDisease" : true, "minX" : 285, "maxX" : 410, "minY" : 34, "maxY" : 83, "prop" : { "x" : 285, "y" : 60, "width" : 114, "height" : 23 }, "textPosition" : { "x" : 307, "y" : 54 }, "connectors" : [ { "edgeId" : 13584, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 398, "y" : 34 }, "b" : { "x" : 410, "y" : 46 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 404, "y" : 40 } } }, "isDisease" : true } ] }, { "id" : 13614, "reactomeId" : 9700436, "displayName" : "ALK point mutant dimers", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 572, "y" : 73 }, "isDisease" : true, "minX" : 516, "maxX" : 703, "minY" : 0, "maxY" : 92, "prop" : { "x" : 516, "y" : 55, "width" : 112, "height" : 37 }, "textPosition" : { "x" : 522, "y" : 56 }, "connectors" : [ { "edgeId" : 13584, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 13596, "type" : "INPUT", "segments" : [ { "from" : { "x" : 634, "y" : 62 }, "to" : { "x" : 674, "y" : 53 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 13596, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 599, "y" : 49 }, "to" : { "x" : 681, "y" : 0 } }, { "from" : { "x" : 681, "y" : 0 }, "to" : { "x" : 698, "y" : 37 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 699, "y" : 41 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 699, "y" : 41 } }, "isDisease" : true } ] }, { "id" : 13618, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 660, "y" : 123 }, "minX" : 640, "maxX" : 681, "minY" : 53, "maxY" : 139, "prop" : { "x" : 640, "y" : 108, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 644, "y" : 113 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 675, "y" : 113 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 675, "y" : 113 } } }, "connectors" : [ { "edgeId" : 13596, "type" : "INPUT", "segments" : [ { "from" : { "x" : 663, "y" : 105 }, "to" : { "x" : 674, "y" : 53 } } ], "stoichiometry" : { "value" : 14, "shape" : { "a" : { "x" : 662, "y" : 73 }, "b" : { "x" : 674, "y" : 85 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 668, "y" : 79 } } }, "isDisease" : true } ] }, { "id" : 13621, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 805, "y" : 114 }, "minX" : 737, "maxX" : 827, "minY" : 50, "maxY" : 130, "prop" : { "x" : 785, "y" : 99, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 789, "y" : 104 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 821, "y" : 104 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 821, "y" : 104 } } }, "connectors" : [ { "edgeId" : 13596, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 788, "y" : 96 }, "to" : { "x" : 737, "y" : 50 } } ], "stoichiometry" : { "value" : 14, "shape" : { "a" : { "x" : 756, "y" : 67 }, "b" : { "x" : 768, "y" : 79 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 762, "y" : 73 } } }, "endShape" : { "a" : { "x" : 780, "y" : 94 }, "b" : { "x" : 788, "y" : 96 }, "c" : { "x" : 786, "y" : 88 }, "type" : "ARROW", "centre" : { "x" : 786, "y" : 88 } }, "isDisease" : true } ] }, { "id" : 13622, "reactomeId" : 9700566, "displayName" : "p-7Y ALK point mutant dimers", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 875, "y" : 64 }, "isDisease" : true, "minX" : 737, "maxX" : 926, "minY" : 46, "maxY" : 83, "prop" : { "x" : 824, "y" : 46, "width" : 102, "height" : 37 }, "textPosition" : { "x" : 825, "y" : 47 }, "connectors" : [ { "edgeId" : 13596, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 818, "y" : 58 }, "to" : { "x" : 737, "y" : 50 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 811, "y" : 61 }, "b" : { "x" : 818, "y" : 58 }, "c" : { "x" : 811, "y" : 53 }, "type" : "ARROW", "centre" : { "x" : 811, "y" : 53 } }, "isDisease" : true } ] }, { "id" : 16182, "reactomeId" : 8948437, "displayName" : "MCL1 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1304, "y" : 3038 }, "minX" : 1268, "maxX" : 1348, "minY" : 3010, "maxY" : 3064, "prop" : { "x" : 1268, "y" : 3012, "width" : 73, "height" : 52 }, "textPosition" : { "x" : 1282, "y" : 3039 }, "connectors" : [ { "edgeId" : 16181, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1348, "y" : 3010 }, "b" : { "x" : 1341, "y" : 3014 }, "c" : { "x" : 1348, "y" : 3018 }, "type" : "ARROW", "centre" : { "x" : 1348, "y" : 3018 } } }, { "id" : 310, "reactomeId" : 179838, "displayName" : "PI(3,4,5)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 247, "y" : 580 }, "minX" : 206, "maxX" : 456, "minY" : 509, "maxY" : 665, "prop" : { "x" : 206, "y" : 565, "width" : 82, "height" : 31 }, "textPosition" : { "x" : 208, "y" : 570 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 283, "y" : 570 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 283, "y" : 570 } } }, "connectors" : [ { "edgeId" : 307, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 247, "y" : 562 }, "to" : { "x" : 248, "y" : 509 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 243, "y" : 555 }, "b" : { "x" : 247, "y" : 562 }, "c" : { "x" : 251, "y" : 555 }, "type" : "ARROW", "centre" : { "x" : 251, "y" : 555 } } }, { "edgeId" : 336, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 246, "y" : 599 }, "to" : { "x" : 246, "y" : 633 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14234, "type" : "INPUT", "segments" : [ { "from" : { "x" : 285, "y" : 599 }, "to" : { "x" : 456, "y" : 665 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14574, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 259, "y" : 562 }, "to" : { "x" : 287, "y" : 532 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 261, "y" : 554 }, "b" : { "x" : 259, "y" : 562 }, "c" : { "x" : 267, "y" : 560 }, "type" : "ARROW", "centre" : { "x" : 267, "y" : 560 } }, "isDisease" : true } ] }, { "id" : 311, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 346, "y" : 527 }, "minX" : 248, "maxX" : 368, "minY" : 509, "maxY" : 543, "prop" : { "x" : 326, "y" : 512, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 330, "y" : 517 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 362, "y" : 517 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 362, "y" : 517 } } }, "connectors" : [ { "edgeId" : 307, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 323, "y" : 523 }, "to" : { "x" : 248, "y" : 509 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 315, "y" : 526 }, "b" : { "x" : 323, "y" : 523 }, "c" : { "x" : 317, "y" : 518 }, "type" : "ARROW", "centre" : { "x" : 317, "y" : 518 } } }, { "edgeId" : 14574, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 323, "y" : 528 }, "to" : { "x" : 287, "y" : 532 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 317, "y" : 533 }, "b" : { "x" : 323, "y" : 528 }, "c" : { "x" : 316, "y" : 525 }, "type" : "ARROW", "centre" : { "x" : 316, "y" : 525 } }, "isDisease" : true } ] }, { "id" : 16183, "reactomeId" : 5661490, "displayName" : "MCL1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1119, "y" : 3011 }, "minX" : 1099, "maxX" : 1146, "minY" : 2994, "maxY" : 3023, "prop" : { "x" : 1099, "y" : 3000, "width" : 41, "height" : 23 }, "textPosition" : { "x" : 1099, "y" : 3001 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1140, "y" : 3000 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1140, "y" : 3000 } } }, "connectors" : [ { "edgeId" : 16181, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15672, "reactomeId" : 8948451, "displayName" : "TWIST1 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1620, "y" : 2260 }, "minX" : 1578, "maxX" : 1669, "minY" : 2232, "maxY" : 2286, "prop" : { "x" : 1578, "y" : 2234, "width" : 84, "height" : 52 }, "textPosition" : { "x" : 1592, "y" : 2261 }, "connectors" : [ { "edgeId" : 15671, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1669, "y" : 2232 }, "b" : { "x" : 1662, "y" : 2236 }, "c" : { "x" : 1669, "y" : 2240 }, "type" : "ARROW", "centre" : { "x" : 1669, "y" : 2240 } } }, { "id" : 16184, "reactomeId" : 909682, "displayName" : "p-Y1054,Y1055-TYK2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1132, "y" : 3223 }, "minX" : 1052, "maxX" : 1283, "minY" : 3020, "maxY" : 3262, "prop" : { "x" : 1076, "y" : 3205, "width" : 113, "height" : 37 }, "innerProp" : { "x" : 1076, "y" : 3211, "width" : 113, "height" : 31 }, "textPosition" : { "x" : 1079, "y" : 3206 }, "nodeAttachments" : [ { "reactomeId" : 909679, "label" : "P", "description" : "O4'-phospho-L-tyrosine at 1055", "shape" : { "a" : { "x" : 1086, "y" : 3199 }, "b" : { "x" : 1098, "y" : 3211 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1092, "y" : 3205 } } }, { "reactomeId" : 909677, "label" : "P", "description" : "O4'-phospho-L-tyrosine at 1054", "shape" : { "a" : { "x" : 1102, "y" : 3199 }, "b" : { "x" : 1114, "y" : 3211 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1108, "y" : 3205 } } } ], "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1189, "y" : 3205 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1189, "y" : 3205 } } }, "connectors" : [ { "edgeId" : 16181, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1137, "y" : 3202 }, "to" : { "x" : 1193, "y" : 3020 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1195, "y" : 3028 }, "b" : { "x" : 1193, "y" : 3020 }, "c" : { "x" : 1187, "y" : 3025 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1187, "y" : 3025 } }, "isDisease" : true }, { "edgeId" : 16212, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1094, "y" : 3245 }, "to" : { "x" : 1052, "y" : 3262 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1089, "y" : 3251 }, "b" : { "x" : 1094, "y" : 3245 }, "c" : { "x" : 1086, "y" : 3244 }, "type" : "ARROW", "centre" : { "x" : 1086, "y" : 3244 } }, "isDisease" : true }, { "edgeId" : 16366, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1192, "y" : 3228 }, "to" : { "x" : 1283, "y" : 3238 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1276, "y" : 3241 }, "b" : { "x" : 1283, "y" : 3238 }, "c" : { "x" : 1277, "y" : 3233 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1277, "y" : 3233 } }, "isDisease" : true } ] }, { "id" : 15673, "reactomeId" : 445442, "displayName" : "TWIST1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1800, "y" : 2237 }, "minX" : 1774, "maxX" : 1832, "minY" : 2220, "maxY" : 2249, "prop" : { "x" : 1774, "y" : 2226, "width" : 52, "height" : 23 }, "textPosition" : { "x" : 1774, "y" : 2227 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1826, "y" : 2226 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1826, "y" : 2226 } } }, "connectors" : [ { "edgeId" : 15671, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 321, "reactomeId" : 1257604, "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 771, "y" : 578 }, "minX" : 702, "maxX" : 840, "minY" : 547, "maxY" : 609, "prop" : { "x" : 702, "y" : 547, "width" : 138, "height" : 62 }, "textPosition" : { "x" : 704, "y" : 556 }, "connectors" : [ ] }, { "id" : 337, "reactomeId" : 167682, "displayName" : "PLCG1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 313, "y" : 646 }, "minX" : 246, "maxX" : 456, "minY" : 629, "maxY" : 665, "prop" : { "x" : 290, "y" : 635, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 290, "y" : 636 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 337, "y" : 635 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 337, "y" : 635 } } }, "connectors" : [ { "edgeId" : 336, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 287, "y" : 641 }, "to" : { "x" : 246, "y" : 633 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14234, "type" : "INPUT", "segments" : [ { "from" : { "x" : 340, "y" : 649 }, "to" : { "x" : 456, "y" : 665 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 338, "reactomeId" : 9699982, "displayName" : "Active ALK:PLCG1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 237, "y" : 725 }, "isFadeOut" : true, "minX" : 182, "maxX" : 293, "minY" : 714, "maxY" : 961, "prop" : { "x" : 182, "y" : 714, "width" : 111, "height" : 23 }, "textPosition" : { "x" : 200, "y" : 702 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 336, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 339, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 238, "y" : 740 }, "to" : { "x" : 253, "y" : 903 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 339, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 233, "y" : 740 }, "to" : { "x" : 202, "y" : 838 } }, { "from" : { "x" : 202, "y" : 838 }, "to" : { "x" : 246, "y" : 953 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 248, "y" : 957 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 248, "y" : 957 } } } ] }, { "id" : 340, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 335, "y" : 843 }, "minX" : 253, "maxX" : 356, "minY" : 827, "maxY" : 903, "prop" : { "x" : 315, "y" : 828, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 319, "y" : 833 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 350, "y" : 833 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 350, "y" : 833 } } }, "connectors" : [ { "edgeId" : 339, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 312, "y" : 857 }, "to" : { "x" : 253, "y" : 903 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 276, "y" : 874 }, "b" : { "x" : 288, "y" : 886 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 282, "y" : 880 } } } }, { "edgeId" : 14426, "type" : "INPUT", "segments" : [ { "from" : { "x" : 322, "y" : 862 }, "to" : { "x" : 291, "y" : 898 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 300, "y" : 874 }, "b" : { "x" : 312, "y" : 886 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 306, "y" : 880 } } }, "isDisease" : true } ] }, { "id" : 341, "reactomeId" : 9699992, "displayName" : "Active ALK:p-4Y PLCG1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 257, "y" : 1128 }, "isFadeOut" : true, "minX" : 204, "maxX" : 310, "minY" : 1015, "maxY" : 1147, "prop" : { "x" : 204, "y" : 1110, "width" : 106, "height" : 37 }, "textPosition" : { "x" : 204, "y" : 1112 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 339, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 256, "y" : 1107 }, "to" : { "x" : 255, "y" : 1015 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 252, "y" : 1100 }, "b" : { "x" : 256, "y" : 1107 }, "c" : { "x" : 260, "y" : 1100 }, "type" : "ARROW", "centre" : { "x" : 260, "y" : 1100 } } } ] }, { "id" : 16213, "reactomeId" : 877348, "displayName" : "TYK2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 917, "y" : 3221 }, "minX" : 897, "maxX" : 983, "minY" : 3204, "maxY" : 3265, "prop" : { "x" : 897, "y" : 3210, "width" : 40, "height" : 23 }, "textPosition" : { "x" : 898, "y" : 3211 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 937, "y" : 3210 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 937, "y" : 3210 } } }, "connectors" : [ { "edgeId" : 16212, "type" : "INPUT", "segments" : [ { "from" : { "x" : 934, "y" : 3236 }, "to" : { "x" : 983, "y" : 3265 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 16214, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 908, "y" : 3299 }, "minX" : 888, "maxX" : 983, "minY" : 3265, "maxY" : 3315, "prop" : { "x" : 888, "y" : 3284, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 892, "y" : 3289 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 923, "y" : 3289 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 923, "y" : 3289 } } }, "connectors" : [ { "edgeId" : 16212, "type" : "INPUT", "segments" : [ { "from" : { "x" : 931, "y" : 3289 }, "to" : { "x" : 983, "y" : 3265 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 951, "y" : 3271 }, "b" : { "x" : 963, "y" : 3283 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 957, "y" : 3277 } } }, "isDisease" : true } ] }, { "id" : 16215, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1084, "y" : 3314 }, "minX" : 1052, "maxX" : 1106, "minY" : 3262, "maxY" : 3330, "prop" : { "x" : 1064, "y" : 3299, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1068, "y" : 3304 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1100, "y" : 3304 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1100, "y" : 3304 } } }, "connectors" : [ { "edgeId" : 16212, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1074, "y" : 3296 }, "to" : { "x" : 1052, "y" : 3262 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1057, "y" : 3273 }, "b" : { "x" : 1069, "y" : 3285 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1063, "y" : 3279 } } }, "endShape" : { "a" : { "x" : 1067, "y" : 3292 }, "b" : { "x" : 1074, "y" : 3296 }, "c" : { "x" : 1074, "y" : 3288 }, "type" : "ARROW", "centre" : { "x" : 1074, "y" : 3288 } }, "isDisease" : true } ] }, { "id" : 16216, "reactomeId" : 447125, "displayName" : "IL10", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1071, "y" : 3468 }, "minX" : 1013, "maxX" : 1094, "minY" : 3273, "maxY" : 3480, "prop" : { "x" : 1054, "y" : 3457, "width" : 34, "height" : 23 }, "textPosition" : { "x" : 1054, "y" : 3458 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1088, "y" : 3457 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1088, "y" : 3457 } } }, "connectors" : [ { "edgeId" : 16212, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1067, "y" : 3454 }, "to" : { "x" : 1015, "y" : 3273 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1021, "y" : 3279 }, "b" : { "x" : 1015, "y" : 3273 }, "c" : { "x" : 1013, "y" : 3281 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1013, "y" : 3281 } }, "isDisease" : true } ] }, { "id" : 16217, "reactomeId" : 448460, "displayName" : "IL22", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 945, "y" : 3470 }, "minX" : 928, "maxX" : 1012, "minY" : 3273, "maxY" : 3482, "prop" : { "x" : 928, "y" : 3459, "width" : 34, "height" : 23 }, "textPosition" : { "x" : 928, "y" : 3460 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 962, "y" : 3459 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 962, "y" : 3459 } } }, "connectors" : [ { "edgeId" : 16212, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 948, "y" : 3456 }, "to" : { "x" : 1010, "y" : 3273 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1012, "y" : 3281 }, "b" : { "x" : 1010, "y" : 3273 }, "c" : { "x" : 1004, "y" : 3278 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1004, "y" : 3278 } }, "isDisease" : true } ] }, { "id" : 348, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 368, "y" : 1019 }, "minX" : 255, "maxX" : 390, "minY" : 980, "maxY" : 1035, "prop" : { "x" : 348, "y" : 1004, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 352, "y" : 1009 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 384, "y" : 1009 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 384, "y" : 1009 } } }, "connectors" : [ { "edgeId" : 339, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 345, "y" : 1018 }, "to" : { "x" : 255, "y" : 1015 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 294, "y" : 1010 }, "b" : { "x" : 306, "y" : 1022 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 300, "y" : 1016 } } }, "endShape" : { "a" : { "x" : 338, "y" : 1022 }, "b" : { "x" : 345, "y" : 1018 }, "c" : { "x" : 338, "y" : 1014 }, "type" : "ARROW", "centre" : { "x" : 338, "y" : 1014 } } }, { "edgeId" : 14426, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 345, "y" : 1007 }, "to" : { "x" : 301, "y" : 980 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 317, "y" : 987 }, "b" : { "x" : 329, "y" : 999 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 323, "y" : 993 } } }, "endShape" : { "a" : { "x" : 337, "y" : 1007 }, "b" : { "x" : 345, "y" : 1007 }, "c" : { "x" : 341, "y" : 1000 }, "type" : "ARROW", "centre" : { "x" : 341, "y" : 1000 } }, "isDisease" : true } ] }, { "id" : 352, "reactomeId" : 1489509, "displayName" : "DAG and IP3 signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 443, "y" : 1172 }, "minX" : 387, "maxX" : 500, "minY" : 1145, "maxY" : 1200, "prop" : { "x" : 387, "y" : 1145, "width" : 113, "height" : 55 }, "textPosition" : { "x" : 395, "y" : 1151 }, "connectors" : [ ] }, { "id" : 356, "reactomeId" : 354153, "displayName" : "SRC-1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1287, "y" : 531 }, "isFadeOut" : true, "minX" : 1264, "maxX" : 1329, "minY" : 520, "maxY" : 543, "prop" : { "x" : 1264, "y" : 520, "width" : 46, "height" : 23 }, "textPosition" : { "x" : 1265, "y" : 521 }, "connectors" : [ { "edgeId" : 355, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1313, "y" : 533 }, "to" : { "x" : 1329, "y" : 536 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 357, "reactomeId" : 9700422, "displayName" : "Active ALK:SRC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2126, "y" : 568 }, "isFadeOut" : true, "minX" : 2077, "maxX" : 2174, "minY" : 557, "maxY" : 648, "prop" : { "x" : 2079, "y" : 557, "width" : 95, "height" : 23 }, "textPosition" : { "x" : 2089, "y" : 545 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 355, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 358, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2128, "y" : 583 }, "to" : { "x" : 2140, "y" : 623 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 358, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2112, "y" : 583 }, "to" : { "x" : 2077, "y" : 611 } }, { "from" : { "x" : 2077, "y" : 611 }, "to" : { "x" : 2128, "y" : 642 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2132, "y" : 644 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2132, "y" : 644 } } } ] }, { "id" : 359, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2188, "y" : 607 }, "isFadeOut" : true, "minX" : 2140, "maxX" : 2208, "minY" : 592, "maxY" : 623, "prop" : { "x" : 2168, "y" : 592, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 2172, "y" : 597 }, "connectors" : [ { "edgeId" : 358, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2165, "y" : 613 }, "to" : { "x" : 2140, "y" : 623 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 360, "reactomeId" : 9700608, "displayName" : "Active ALK:p-Y419 SRC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2148, "y" : 780 }, "isFadeOut" : true, "minX" : 2087, "maxX" : 2210, "minY" : 680, "maxY" : 799, "prop" : { "x" : 2087, "y" : 762, "width" : 123, "height" : 37 }, "textPosition" : { "x" : 2088, "y" : 764 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 358, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2147, "y" : 759 }, "to" : { "x" : 2143, "y" : 680 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2143, "y" : 752 }, "b" : { "x" : 2147, "y" : 759 }, "c" : { "x" : 2151, "y" : 752 }, "type" : "ARROW", "centre" : { "x" : 2151, "y" : 752 } } } ] }, { "id" : 361, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2194, "y" : 696 }, "isFadeOut" : true, "minX" : 2143, "maxX" : 2215, "minY" : 680, "maxY" : 712, "prop" : { "x" : 2174, "y" : 681, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 2178, "y" : 686 }, "connectors" : [ { "edgeId" : 358, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2171, "y" : 689 }, "to" : { "x" : 2143, "y" : 680 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2163, "y" : 691 }, "b" : { "x" : 2171, "y" : 689 }, "c" : { "x" : 2166, "y" : 683 }, "type" : "ARROW", "centre" : { "x" : 2166, "y" : 683 } } } ] }, { "id" : 15724, "reactomeId" : 8948472, "displayName" : "IRF4 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 2115, "y" : 2067 }, "minX" : 2082, "maxX" : 2157, "minY" : 2011, "maxY" : 2093, "prop" : { "x" : 2082, "y" : 2041, "width" : 66, "height" : 52 }, "textPosition" : { "x" : 2095, "y" : 2068 }, "connectors" : [ { "edgeId" : 15723, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2157, "y" : 2043 }, "to" : { "x" : 2143, "y" : 2011 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15727, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 2155, "y" : 2039 }, "b" : { "x" : 2148, "y" : 2043 }, "c" : { "x" : 2155, "y" : 2047 }, "type" : "ARROW", "centre" : { "x" : 2155, "y" : 2047 } } }, { "id" : 15726, "reactomeId" : 9850945, "displayName" : "pY705, S727-STAT3 dimer:IRF4 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2367, "y" : 2000 }, "isDisease" : true, "minX" : 2300, "maxX" : 2441, "minY" : 1976, "maxY" : 2056, "prop" : { "x" : 2300, "y" : 1982, "width" : 135, "height" : 37 }, "textPosition" : { "x" : 2301, "y" : 1984 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2435, "y" : 1982 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2435, "y" : 1982 } } }, "connectors" : [ { "edgeId" : 15723, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15727, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 2368, "y" : 2022 }, "to" : { "x" : 2370, "y" : 2056 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2366, "y" : 2049 }, "b" : { "x" : 2370, "y" : 2056 }, "c" : { "x" : 2374, "y" : 2049 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2374, "y" : 2049 } }, "isDisease" : true } ] }, { "id" : 15728, "reactomeId" : 1015679, "displayName" : "IRF4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2801, "y" : 2084 }, "minX" : 2784, "maxX" : 2824, "minY" : 2067, "maxY" : 2096, "prop" : { "x" : 2784, "y" : 2073, "width" : 34, "height" : 23 }, "textPosition" : { "x" : 2784, "y" : 2074 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2818, "y" : 2073 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2818, "y" : 2073 } } }, "connectors" : [ { "edgeId" : 15727, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14709, "reactomeId" : 9711940, "displayName" : "IRS:ALK fusion proteins", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1671, "y" : 428 }, "isDisease" : true, "minX" : 1624, "maxX" : 1799, "minY" : 375, "maxY" : 447, "prop" : { "x" : 1624, "y" : 410, "width" : 94, "height" : 37 }, "textPosition" : { "x" : 1622, "y" : 412 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1718, "y" : 410 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1718, "y" : 410 } } }, "connectors" : [ { "edgeId" : 14708, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14710, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1721, "y" : 425 }, "to" : { "x" : 1770, "y" : 422 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14710, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1712, "y" : 407 }, "to" : { "x" : 1790, "y" : 375 } }, { "from" : { "x" : 1790, "y" : 375 }, "to" : { "x" : 1795, "y" : 404 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1795, "y" : 408 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1795, "y" : 408 } }, "isDisease" : true } ] }, { "id" : 14711, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1758, "y" : 465 }, "minX" : 1738, "maxX" : 1843, "minY" : 422, "maxY" : 515, "prop" : { "x" : 1738, "y" : 450, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1742, "y" : 455 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1773, "y" : 455 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1773, "y" : 455 } } }, "connectors" : [ { "edgeId" : 14608, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1781, "y" : 476 }, "to" : { "x" : 1843, "y" : 515 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 1806, "y" : 489 }, "b" : { "x" : 1818, "y" : 501 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1812, "y" : 495 } } }, "isDisease" : true }, { "edgeId" : 14710, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1762, "y" : 447 }, "to" : { "x" : 1770, "y" : 422 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14712, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1869, "y" : 454 }, "minX" : 1828, "maxX" : 1891, "minY" : 420, "maxY" : 512, "prop" : { "x" : 1849, "y" : 439, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1853, "y" : 444 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1885, "y" : 444 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1885, "y" : 444 } } }, "connectors" : [ { "edgeId" : 14608, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1871, "y" : 473 }, "to" : { "x" : 1877, "y" : 512 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 1868, "y" : 486 }, "b" : { "x" : 1880, "y" : 498 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1874, "y" : 492 } } }, "endShape" : { "a" : { "x" : 1876, "y" : 479 }, "b" : { "x" : 1871, "y" : 473 }, "c" : { "x" : 1868, "y" : 480 }, "type" : "ARROW", "centre" : { "x" : 1868, "y" : 480 } }, "isDisease" : true }, { "edgeId" : 14710, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1850, "y" : 436 }, "to" : { "x" : 1828, "y" : 420 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1842, "y" : 435 }, "b" : { "x" : 1850, "y" : 436 }, "c" : { "x" : 1847, "y" : 429 }, "type" : "ARROW", "centre" : { "x" : 1847, "y" : 429 } }, "isDisease" : true } ] }, { "id" : 14713, "reactomeId" : 9712076, "displayName" : "p-Y IRS1:ALK fusion proteins", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1968, "y" : 423 }, "isDisease" : true, "minX" : 1828, "maxX" : 2038, "minY" : 399, "maxY" : 442, "prop" : { "x" : 1904, "y" : 405, "width" : 128, "height" : 37 }, "textPosition" : { "x" : 1904, "y" : 407 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2032, "y" : 405 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2032, "y" : 405 } } }, "connectors" : [ { "edgeId" : 14710, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1901, "y" : 421 }, "to" : { "x" : 1828, "y" : 420 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1894, "y" : 425 }, "b" : { "x" : 1901, "y" : 421 }, "c" : { "x" : 1894, "y" : 417 }, "type" : "ARROW", "centre" : { "x" : 1894, "y" : 417 } }, "isDisease" : true } ] }, { "id" : 16761, "reactomeId" : 6806003, "displayName" : "Regulation of TP53 Expression and Degradation", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 743, "y" : 3011 }, "minX" : 661, "maxX" : 826, "minY" : 2977, "maxY" : 3046, "prop" : { "x" : 661, "y" : 2977, "width" : 165, "height" : 69 }, "textPosition" : { "x" : 674, "y" : 2983 }, "connectors" : [ ] }, { "id" : 15738, "reactomeId" : 606320, "displayName" : "NPM1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1277, "y" : 2614 }, "minX" : 1256, "maxX" : 1347, "minY" : 2590, "maxY" : 2626, "prop" : { "x" : 1256, "y" : 2603, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 1256, "y" : 2604 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1299, "y" : 2603 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1299, "y" : 2603 } } }, "connectors" : [ { "edgeId" : 15737, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1302, "y" : 2606 }, "to" : { "x" : 1347, "y" : 2590 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15740, "reactomeId" : 4088019, "displayName" : "FOXM1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1273, "y" : 2573 }, "minX" : 1248, "maxX" : 1347, "minY" : 2556, "maxY" : 2590, "prop" : { "x" : 1248, "y" : 2562, "width" : 50, "height" : 23 }, "textPosition" : { "x" : 1248, "y" : 2563 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1298, "y" : 2562 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1298, "y" : 2562 } } }, "connectors" : [ { "edgeId" : 15737, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1301, "y" : 2578 }, "to" : { "x" : 1347, "y" : 2590 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15741, "reactomeId" : 9850901, "displayName" : "NPM1-ALK;NPM1:FOXM1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1351, "y" : 2660 }, "isDisease" : true, "minX" : 1294, "maxX" : 1414, "minY" : 2636, "maxY" : 2709, "prop" : { "x" : 1294, "y" : 2642, "width" : 114, "height" : 37 }, "textPosition" : { "x" : 1295, "y" : 2644 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1408, "y" : 2642 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1408, "y" : 2642 } } }, "connectors" : [ { "edgeId" : 15737, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15746, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1351, "y" : 2682 }, "to" : { "x" : 1352, "y" : 2709 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1348, "y" : 2702 }, "b" : { "x" : 1352, "y" : 2709 }, "c" : { "x" : 1356, "y" : 2702 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1356, "y" : 2702 } }, "isDisease" : true } ] }, { "id" : 16769, "reactomeId" : 6804449, "displayName" : "Ub:p-S15,S20-TP53", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1786, "y" : 2726 }, "minX" : 1744, "maxX" : 1834, "minY" : 2696, "maxY" : 2751, "prop" : { "x" : 1744, "y" : 2702, "width" : 84, "height" : 49 }, "textPosition" : { "x" : 1751, "y" : 2716 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1828, "y" : 2702 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1828, "y" : 2702 } } }, "connectors" : [ { "edgeId" : 17163, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15747, "reactomeId" : 4088295, "displayName" : "CCNB1 Gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1264, "y" : 2746 }, "minX" : 1223, "maxX" : 1313, "minY" : 2718, "maxY" : 2772, "prop" : { "x" : 1223, "y" : 2720, "width" : 83, "height" : 52 }, "textPosition" : { "x" : 1238, "y" : 2747 }, "connectors" : [ { "edgeId" : 15746, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1313, "y" : 2718 }, "b" : { "x" : 1306, "y" : 2722 }, "c" : { "x" : 1313, "y" : 2726 }, "type" : "ARROW", "centre" : { "x" : 1313, "y" : 2726 } } }, { "id" : 15748, "reactomeId" : 68901, "displayName" : "CCNB1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1432, "y" : 2721 }, "minX" : 1408, "maxX" : 1463, "minY" : 2704, "maxY" : 2733, "prop" : { "x" : 1408, "y" : 2710, "width" : 49, "height" : 23 }, "textPosition" : { "x" : 1408, "y" : 2711 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1457, "y" : 2710 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1457, "y" : 2710 } } }, "connectors" : [ { "edgeId" : 15746, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14230, "reactomeId" : 9710874, "displayName" : "GRB2- and PLC gamma-binding ALK fusion protein dimers", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1726, "y" : 882 }, "isDisease" : true, "minX" : 456, "maxX" : 1792, "minY" : 665, "maxY" : 926, "prop" : { "x" : 1660, "y" : 850, "width" : 132, "height" : 65 }, "textPosition" : { "x" : 1660, "y" : 851 }, "connectors" : [ { "edgeId" : 14229, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1760, "y" : 921 }, "to" : { "x" : 1773, "y" : 926 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14234, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1654, "y" : 867 }, "to" : { "x" : 1446, "y" : 822 } }, { "from" : { "x" : 1446, "y" : 822 }, "to" : { "x" : 456, "y" : 665 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14232, "reactomeId" : 8983328, "displayName" : "GRB2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1696, "y" : 951 }, "minX" : 1676, "maxX" : 1979, "minY" : 926, "maxY" : 963, "prop" : { "x" : 1676, "y" : 940, "width" : 41, "height" : 23 }, "textPosition" : { "x" : 1676, "y" : 941 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1717, "y" : 940 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1717, "y" : 940 } } }, "connectors" : [ { "edgeId" : 14925, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1720, "y" : 951 }, "to" : { "x" : 1979, "y" : 956 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14229, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1720, "y" : 944 }, "to" : { "x" : 1773, "y" : 926 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14233, "reactomeId" : 9710907, "displayName" : "ALK fusion dimers:GRB2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1889, "y" : 923 }, "isDisease" : true, "minX" : 1831, "maxX" : 1954, "minY" : 899, "maxY" : 942, "prop" : { "x" : 1831, "y" : 905, "width" : 117, "height" : 37 }, "textPosition" : { "x" : 1846, "y" : 907 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1948, "y" : 905 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1948, "y" : 905 } } }, "connectors" : [ { "edgeId" : 14229, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15259, "reactomeId" : 9725002, "displayName" : "CUL1:RBX1:SKP1:ZC3HC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1405, "y" : 2417 }, "minX" : 1350, "maxX" : 1467, "minY" : 2393, "maxY" : 2461, "prop" : { "x" : 1350, "y" : 2399, "width" : 111, "height" : 37 }, "textPosition" : { "x" : 1359, "y" : 2401 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1461, "y" : 2399 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1461, "y" : 2399 } } }, "connectors" : [ { "edgeId" : 15258, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1413, "y" : 2439 }, "to" : { "x" : 1425, "y" : 2461 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15260, "reactomeId" : 9725012, "displayName" : "NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1349, "y" : 2531 }, "isDisease" : true, "minX" : 1284, "maxX" : 2033, "minY" : 2342, "maxY" : 2994, "prop" : { "x" : 1284, "y" : 2506, "width" : 131, "height" : 51 }, "textPosition" : { "x" : 1287, "y" : 2508 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1415, "y" : 2506 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1415, "y" : 2506 } } }, "connectors" : [ { "edgeId" : 17176, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1346, "y" : 2503 }, "to" : { "x" : 1328, "y" : 2342 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1324, "y" : 2342 }, "b" : { "x" : 1332, "y" : 2342 }, "c" : { "x" : 1328, "y" : 2342 }, "type" : "STOP", "centre" : { "x" : 1328, "y" : 2342 } }, "isDisease" : true }, { "edgeId" : 15408, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1418, "y" : 2535 }, "to" : { "x" : 1802, "y" : 2560 } }, { "from" : { "x" : 1802, "y" : 2560 }, "to" : { "x" : 1888, "y" : 2604 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1880, "y" : 2604 }, "b" : { "x" : 1888, "y" : 2604 }, "c" : { "x" : 1884, "y" : 2597 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1884, "y" : 2597 } }, "isDisease" : true }, { "edgeId" : 15460, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1366, "y" : 2560 }, "to" : { "x" : 1568, "y" : 2850 } }, { "from" : { "x" : 1568, "y" : 2850 }, "to" : { "x" : 1578, "y" : 2994 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1574, "y" : 2987 }, "b" : { "x" : 1578, "y" : 2994 }, "c" : { "x" : 1582, "y" : 2987 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1582, "y" : 2987 } }, "isDisease" : true }, { "edgeId" : 15472, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1418, "y" : 2532 }, "to" : { "x" : 1910, "y" : 2545 } }, { "from" : { "x" : 1910, "y" : 2545 }, "to" : { "x" : 2033, "y" : 2449 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2030, "y" : 2456 }, "b" : { "x" : 2033, "y" : 2449 }, "c" : { "x" : 2025, "y" : 2450 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2025, "y" : 2450 } }, "isDisease" : true }, { "edgeId" : 15737, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1348, "y" : 2560 }, "to" : { "x" : 1347, "y" : 2590 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15258, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1376, "y" : 2503 }, "to" : { "x" : 1425, "y" : 2461 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15274, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 16126, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1418, "y" : 2553 }, "to" : { "x" : 2006, "y" : 2757 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1998, "y" : 2759 }, "b" : { "x" : 2006, "y" : 2757 }, "c" : { "x" : 2001, "y" : 2751 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2001, "y" : 2751 } }, "isDisease" : true } ] }, { "id" : 14236, "reactomeId" : 9710910, "displayName" : "PLC gamma-binding ALK fusion proteins:PLCG1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 320, "y" : 787 }, "isDisease" : true, "minX" : 255, "maxX" : 433, "minY" : 756, "maxY" : 943, "prop" : { "x" : 255, "y" : 762, "width" : 131, "height" : 51 }, "textPosition" : { "x" : 254, "y" : 764 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 386, "y" : 762 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 386, "y" : 762 } } }, "connectors" : [ { "edgeId" : 14426, "type" : "INPUT", "segments" : [ { "from" : { "x" : 313, "y" : 816 }, "to" : { "x" : 291, "y" : 898 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14426, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 350, "y" : 816 }, "to" : { "x" : 433, "y" : 881 } }, { "from" : { "x" : 433, "y" : 881 }, "to" : { "x" : 307, "y" : 937 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 303, "y" : 939 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 303, "y" : 939 } }, "isDisease" : true }, { "edgeId" : 14234, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 413, "reactomeId" : 9700592, "displayName" : "ALK dimer:ligand:type I ALK binding TKI", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 901, "y" : 148 }, "isDisease" : true, "isFadeOut" : true, "minX" : 842, "maxX" : 960, "minY" : 123, "maxY" : 201, "prop" : { "x" : 842, "y" : 123, "width" : 118, "height" : 51 }, "textPosition" : { "x" : 841, "y" : 125 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 103, "type" : "INHIBITOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 895, "y" : 177 }, "to" : { "x" : 889, "y" : 200 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 885, "y" : 199 }, "b" : { "x" : 893, "y" : 201 }, "c" : { "x" : 889, "y" : 200 }, "type" : "STOP", "centre" : { "x" : 889, "y" : 200 } } }, { "edgeId" : 15480, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 15261, "reactomeId" : 9725021, "displayName" : "NPM1-p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:ZC3HC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1529, "y" : 2457 }, "isDisease" : true, "minX" : 1467, "maxX" : 1628, "minY" : 2426, "maxY" : 2483, "prop" : { "x" : 1467, "y" : 2432, "width" : 125, "height" : 51 }, "textPosition" : { "x" : 1467, "y" : 2420 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1592, "y" : 2432 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1592, "y" : 2432 } } }, "connectors" : [ { "edgeId" : 15258, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15262, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1595, "y" : 2457 }, "to" : { "x" : 1628, "y" : 2457 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15263, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1606, "y" : 2410 }, "minX" : 1586, "maxX" : 1628, "minY" : 2394, "maxY" : 2457, "prop" : { "x" : 1586, "y" : 2395, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1590, "y" : 2400 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1621, "y" : 2400 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1621, "y" : 2400 } } }, "connectors" : [ { "edgeId" : 15262, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1613, "y" : 2429 }, "to" : { "x" : 1628, "y" : 2457 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 416, "reactomeId" : 9699973, "displayName" : "type I ALK-binding TKIs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 529, "y" : 292 }, "isDisease" : true, "isFadeOut" : true, "minX" : 469, "maxX" : 613, "minY" : 155, "maxY" : 311, "prop" : { "x" : 469, "y" : 274, "width" : 121, "height" : 37 }, "textPosition" : { "x" : 469, "y" : 275 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 15480, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 540, "y" : 268 }, "to" : { "x" : 613, "y" : 155 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 15264, "reactomeId" : 9725027, "displayName" : "NPM1p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:p-S354 ZC3HC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1766, "y" : 2457 }, "isDisease" : true, "minX" : 1671, "maxX" : 1835, "minY" : 2419, "maxY" : 2490, "prop" : { "x" : 1703, "y" : 2425, "width" : 126, "height" : 65 }, "textPosition" : { "x" : 1703, "y" : 2427 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1829, "y" : 2425 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1829, "y" : 2425 } } }, "connectors" : [ { "edgeId" : 15262, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1700, "y" : 2457 }, "to" : { "x" : 1671, "y" : 2458 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1693, "y" : 2461 }, "b" : { "x" : 1700, "y" : 2457 }, "c" : { "x" : 1693, "y" : 2453 }, "type" : "ARROW", "centre" : { "x" : 1693, "y" : 2453 } }, "isDisease" : true } ] }, { "id" : 15265, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1699, "y" : 2396 }, "minX" : 1671, "maxX" : 1721, "minY" : 2380, "maxY" : 2458, "prop" : { "x" : 1679, "y" : 2381, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1683, "y" : 2386 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1715, "y" : 2386 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1715, "y" : 2386 } } }, "connectors" : [ { "edgeId" : 15262, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1692, "y" : 2415 }, "to" : { "x" : 1671, "y" : 2458 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1693, "y" : 2423 }, "b" : { "x" : 1692, "y" : 2415 }, "c" : { "x" : 1685, "y" : 2419 }, "type" : "ARROW", "centre" : { "x" : 1685, "y" : 2419 } }, "isDisease" : true } ] }, { "id" : 15266, "reactomeId" : 109856, "displayName" : "p-Y185,Y187 MAPK1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1656, "y" : 2349 }, "minX" : 1609, "maxX" : 1709, "minY" : 2325, "maxY" : 2450, "prop" : { "x" : 1609, "y" : 2331, "width" : 94, "height" : 37 }, "textPosition" : { "x" : 1611, "y" : 2333 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1703, "y" : 2331 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1703, "y" : 2331 } } }, "connectors" : [ { "edgeId" : 15262, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1655, "y" : 2371 }, "to" : { "x" : 1653, "y" : 2442 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1652, "y" : 2446 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1652, "y" : 2446 } }, "isDisease" : true } ] }, { "id" : 15783, "reactomeId" : 9850859, "displayName" : "IL10RA gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1674, "y" : 3029 }, "minX" : 1633, "maxX" : 1722, "minY" : 3001, "maxY" : 3055, "prop" : { "x" : 1633, "y" : 3003, "width" : 82, "height" : 52 }, "textPosition" : { "x" : 1647, "y" : 3030 }, "connectors" : [ { "edgeId" : 15782, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1722, "y" : 3001 }, "b" : { "x" : 1715, "y" : 3005 }, "c" : { "x" : 1722, "y" : 3009 }, "type" : "ARROW", "centre" : { "x" : 1722, "y" : 3009 } } }, { "id" : 15784, "reactomeId" : 449841, "displayName" : "IL10RA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1741, "y" : 3370 }, "minX" : 1716, "maxX" : 1772, "minY" : 3353, "maxY" : 3382, "prop" : { "x" : 1716, "y" : 3359, "width" : 50, "height" : 23 }, "textPosition" : { "x" : 1716, "y" : 3360 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1766, "y" : 3359 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1766, "y" : 3359 } } }, "connectors" : [ { "edgeId" : 15782, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15785, "reactomeId" : 9850905, "displayName" : "crizotinib:NPM1-ALK fusion dimer", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1850, "y" : 3210 }, "isDisease" : true, "minX" : 1743, "maxX" : 1923, "minY" : 3089, "maxY" : 3229, "prop" : { "x" : 1784, "y" : 3192, "width" : 133, "height" : 37 }, "textPosition" : { "x" : 1785, "y" : 3194 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1917, "y" : 3192 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1917, "y" : 3192 } } }, "connectors" : [ { "edgeId" : 15782, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1833, "y" : 3189 }, "to" : { "x" : 1743, "y" : 3089 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1751, "y" : 3091 }, "b" : { "x" : 1743, "y" : 3089 }, "c" : { "x" : 1745, "y" : 3097 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1745, "y" : 3097 } }, "isDisease" : true } ] }, { "id" : 15275, "reactomeId" : 9699991, "displayName" : "NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1073, "y" : 2534 }, "isDisease" : true, "minX" : 947, "maxX" : 1145, "minY" : 2503, "maxY" : 3255, "prop" : { "x" : 1008, "y" : 2509, "width" : 131, "height" : 51 }, "textPosition" : { "x" : 1011, "y" : 2511 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1139, "y" : 2509 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1139, "y" : 2509 } } }, "connectors" : [ { "edgeId" : 16394, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1075, "y" : 2563 }, "to" : { "x" : 1090, "y" : 2711 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1085, "y" : 2705 }, "b" : { "x" : 1090, "y" : 2711 }, "c" : { "x" : 1093, "y" : 2704 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1093, "y" : 2704 } }, "isDisease" : true }, { "edgeId" : 16212, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1058, "y" : 2563 }, "to" : { "x" : 947, "y" : 2756 } }, { "from" : { "x" : 947, "y" : 2756 }, "to" : { "x" : 1012, "y" : 3255 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1007, "y" : 3249 }, "b" : { "x" : 1012, "y" : 3255 }, "c" : { "x" : 1015, "y" : 3248 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1015, "y" : 3248 } }, "isDisease" : true }, { "edgeId" : 15274, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15276, "reactomeId" : 9724998, "displayName" : "NPM dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1106, "y" : 2419 }, "minX" : 1070, "maxX" : 1205, "minY" : 2402, "maxY" : 2531, "prop" : { "x" : 1070, "y" : 2408, "width" : 73, "height" : 23 }, "textPosition" : { "x" : 1085, "y" : 2396 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1143, "y" : 2408 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1143, "y" : 2408 } } }, "connectors" : [ { "edgeId" : 15274, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1116, "y" : 2434 }, "to" : { "x" : 1205, "y" : 2531 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1197, "y" : 2529 }, "b" : { "x" : 1205, "y" : 2531 }, "c" : { "x" : 1203, "y" : 2523 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1203, "y" : 2523 } }, "isDisease" : true } ] }, { "id" : 16813, "reactomeId" : 453279, "displayName" : "Mitotic G1 phase and G1/S transition", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1458, "y" : 2245 }, "minX" : 1375, "maxX" : 1541, "minY" : 2214, "maxY" : 2277, "prop" : { "x" : 1375, "y" : 2214, "width" : 166, "height" : 63 }, "textPosition" : { "x" : 1381, "y" : 2224 }, "connectors" : [ ] }, { "id" : 15790, "reactomeId" : 6783783, "displayName" : "Interleukin-10 signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1532, "y" : 3378 }, "minX" : 1470, "maxX" : 1595, "minY" : 3352, "maxY" : 3405, "prop" : { "x" : 1470, "y" : 3352, "width" : 125, "height" : 53 }, "textPosition" : { "x" : 1479, "y" : 3357 }, "connectors" : [ ] }, { "id" : 15284, "reactomeId" : 9725096, "displayName" : "ALK gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1246, "y" : 1420 }, "isFadeOut" : true, "minX" : 1215, "maxX" : 1326, "minY" : 1392, "maxY" : 1446, "prop" : { "x" : 1215, "y" : 1394, "width" : 63, "height" : 52 }, "textPosition" : { "x" : 1226, "y" : 1421 }, "connectors" : [ { "edgeId" : 15283, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15325, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1287, "y" : 1396 }, "to" : { "x" : 1326, "y" : 1396 } } ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1285, "y" : 1392 }, "b" : { "x" : 1278, "y" : 1396 }, "c" : { "x" : 1285, "y" : 1400 }, "type" : "ARROW", "centre" : { "x" : 1285, "y" : 1400 } } }, { "id" : 15285, "reactomeId" : 9725109, "displayName" : "MYC/MYCN:ALK gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1297, "y" : 1308 }, "isFadeOut" : true, "minX" : 1053, "maxX" : 1349, "minY" : 1290, "maxY" : 1367, "prop" : { "x" : 1245, "y" : 1290, "width" : 104, "height" : 37 }, "textPosition" : { "x" : 1247, "y" : 1292 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 15283, "type" : "ACTIVATOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1242, "y" : 1320 }, "to" : { "x" : 1053, "y" : 1365 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1059, "y" : 1360 }, "b" : { "x" : 1053, "y" : 1365 }, "c" : { "x" : 1061, "y" : 1367 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1061, "y" : 1367 } } }, { "edgeId" : 15325, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14774, "reactomeId" : 9711944, "displayName" : "STAT3-activating ALK mutants", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 807, "y" : 1477 }, "isDisease" : true, "minX" : 751, "maxX" : 887, "minY" : 1459, "maxY" : 1537, "prop" : { "x" : 751, "y" : 1459, "width" : 112, "height" : 37 }, "textPosition" : { "x" : 750, "y" : 1460 }, "connectors" : [ { "edgeId" : 14773, "type" : "INPUT", "segments" : [ { "from" : { "x" : 831, "y" : 1502 }, "to" : { "x" : 887, "y" : 1537 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14779, "reactomeId" : 9711935, "displayName" : "STAT3-activating ALK mutants:STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 895, "y" : 1605 }, "isDisease" : true, "minX" : 834, "maxX" : 963, "minY" : 1581, "maxY" : 1675, "prop" : { "x" : 834, "y" : 1587, "width" : 123, "height" : 37 }, "textPosition" : { "x" : 838, "y" : 1575 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 957, "y" : 1587 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 957, "y" : 1587 } } }, "connectors" : [ { "edgeId" : 14773, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14780, "type" : "INPUT", "segments" : [ { "from" : { "x" : 900, "y" : 1627 }, "to" : { "x" : 907, "y" : 1647 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14780, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 878, "y" : 1627 }, "to" : { "x" : 849, "y" : 1656 } }, { "from" : { "x" : 849, "y" : 1656 }, "to" : { "x" : 893, "y" : 1670 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 897, "y" : 1671 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 897, "y" : 1671 } }, "isDisease" : true } ] }, { "id" : 14781, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 996, "y" : 1638 }, "minX" : 907, "maxX" : 1017, "minY" : 1622, "maxY" : 1654, "prop" : { "x" : 976, "y" : 1623, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 980, "y" : 1628 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1011, "y" : 1628 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1011, "y" : 1628 } } }, "connectors" : [ { "edgeId" : 14780, "type" : "INPUT", "segments" : [ { "from" : { "x" : 973, "y" : 1640 }, "to" : { "x" : 907, "y" : 1647 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 934, "y" : 1637 }, "b" : { "x" : 946, "y" : 1649 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 940, "y" : 1643 } } }, "isDisease" : true } ] }, { "id" : 14782, "reactomeId" : 9712038, "displayName" : "STAT3-activating ALK mutants:p-Y STAT3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 909, "y" : 1767 }, "isDisease" : true, "minX" : 853, "maxX" : 971, "minY" : 1695, "maxY" : 1793, "prop" : { "x" : 853, "y" : 1742, "width" : 112, "height" : 51 }, "textPosition" : { "x" : 852, "y" : 1744 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 965, "y" : 1742 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 965, "y" : 1742 } } }, "connectors" : [ { "edgeId" : 15625, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14780, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 909, "y" : 1739 }, "to" : { "x" : 910, "y" : 1695 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 905, "y" : 1732 }, "b" : { "x" : 909, "y" : 1739 }, "c" : { "x" : 913, "y" : 1732 }, "type" : "ARROW", "centre" : { "x" : 913, "y" : 1732 } }, "isDisease" : true } ] }, { "id" : 14783, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 837, "y" : 1711 }, "minX" : 817, "maxX" : 910, "minY" : 1694, "maxY" : 1727, "prop" : { "x" : 817, "y" : 1696, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 821, "y" : 1701 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 853, "y" : 1701 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 853, "y" : 1701 } } }, "connectors" : [ { "edgeId" : 14780, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 861, "y" : 1706 }, "to" : { "x" : 910, "y" : 1695 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 879, "y" : 1694 }, "b" : { "x" : 891, "y" : 1706 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 885, "y" : 1700 } } }, "endShape" : { "a" : { "x" : 867, "y" : 1701 }, "b" : { "x" : 861, "y" : 1706 }, "c" : { "x" : 869, "y" : 1708 }, "type" : "ARROW", "centre" : { "x" : 869, "y" : 1708 } }, "isDisease" : true } ] }, { "id" : 14784, "reactomeId" : 9713538, "displayName" : "SHC-binding ALK mutant dimers", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1657, "y" : 632 }, "isDisease" : true, "minX" : 1601, "maxX" : 1717, "minY" : 586, "maxY" : 651, "prop" : { "x" : 1601, "y" : 614, "width" : 112, "height" : 37 }, "textPosition" : { "x" : 1601, "y" : 615 }, "connectors" : [ { "edgeId" : 13587, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1681, "y" : 608 }, "to" : { "x" : 1717, "y" : 586 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15818, "reactomeId" : 1911481, "displayName" : "NOTCH1 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1503, "y" : 2172 }, "minX" : 1457, "maxX" : 1583, "minY" : 2093, "maxY" : 2198, "prop" : { "x" : 1457, "y" : 2146, "width" : 92, "height" : 52 }, "textPosition" : { "x" : 1472, "y" : 2173 }, "connectors" : [ { "edgeId" : 15817, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1558, "y" : 2148 }, "to" : { "x" : 1583, "y" : 2093 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15820, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1556, "y" : 2144 }, "b" : { "x" : 1549, "y" : 2148 }, "c" : { "x" : 1556, "y" : 2152 }, "type" : "ARROW", "centre" : { "x" : 1556, "y" : 2152 } } }, { "id" : 15819, "reactomeId" : 9850937, "displayName" : "p-Y705,S727 -STAT3 dimer: NOTCH gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1310, "y" : 2099 }, "minX" : 1260, "maxX" : 1366, "minY" : 2068, "maxY" : 2152, "prop" : { "x" : 1260, "y" : 2074, "width" : 100, "height" : 51 }, "textPosition" : { "x" : 1262, "y" : 2076 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1360, "y" : 2074 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1360, "y" : 2074 } } }, "connectors" : [ { "edgeId" : 15817, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15820, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1310, "y" : 2128 }, "to" : { "x" : 1310, "y" : 2152 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1306, "y" : 2145 }, "b" : { "x" : 1310, "y" : 2152 }, "c" : { "x" : 1314, "y" : 2145 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1314, "y" : 2145 } }, "isDisease" : true } ] }, { "id" : 15821, "reactomeId" : 1606559, "displayName" : "NOTCH1 mRNA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "RNA", "position" : { "x" : 936, "y" : 2167 }, "minX" : 870, "maxX" : 1002, "minY" : 2148, "maxY" : 2187, "prop" : { "x" : 870, "y" : 2148, "width" : 132, "height" : 39 }, "textPosition" : { "x" : 887, "y" : 2157 }, "connectors" : [ { "edgeId" : 15820, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15838, "reactomeId" : 9850883, "displayName" : "DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2539, "y" : 1579 }, "isFadeOut" : true, "minX" : 2477, "maxX" : 2602, "minY" : 1508, "maxY" : 1605, "prop" : { "x" : 2477, "y" : 1554, "width" : 125, "height" : 51 }, "textPosition" : { "x" : 2477, "y" : 1556 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 14094, "type" : "INHIBITOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2538, "y" : 1551 }, "to" : { "x" : 2538, "y" : 1508 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2534, "y" : 1508 }, "b" : { "x" : 2542, "y" : 1508 }, "c" : { "x" : 2538, "y" : 1508 }, "type" : "STOP", "centre" : { "x" : 2538, "y" : 1508 } } }, { "edgeId" : 16003, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 15326, "reactomeId" : 3215043, "displayName" : "MYC,MYCN", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1392, "y" : 1400 }, "isFadeOut" : true, "minX" : 1326, "maxX" : 1428, "minY" : 1389, "maxY" : 1412, "prop" : { "x" : 1356, "y" : 1389, "width" : 72, "height" : 23 }, "textPosition" : { "x" : 1356, "y" : 1390 }, "connectors" : [ { "edgeId" : 15325, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1350, "y" : 1397 }, "to" : { "x" : 1326, "y" : 1396 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 15844, "reactomeId" : 212181, "displayName" : "DNMT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2214, "y" : 1644 }, "minX" : 1556, "maxX" : 2247, "minY" : 1578, "maxY" : 1907, "prop" : { "x" : 2188, "y" : 1633, "width" : 53, "height" : 23 }, "textPosition" : { "x" : 2189, "y" : 1634 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2241, "y" : 1633 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2241, "y" : 1633 } } }, "connectors" : [ { "edgeId" : 15909, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 15989, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2185, "y" : 1654 }, "to" : { "x" : 1556, "y" : 1907 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 16003, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2218, "y" : 1630 }, "to" : { "x" : 2238, "y" : 1578 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 16061, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 2185, "y" : 1646 }, "to" : { "x" : 1902, "y" : 1675 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1902, "y" : 1671 }, "b" : { "x" : 1902, "y" : 1679 }, "c" : { "x" : 1902, "y" : 1675 }, "type" : "STOP", "centre" : { "x" : 1902, "y" : 1675 } }, "isDisease" : true } ] }, { "id" : 16370, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1291, "y" : 3311 }, "minX" : 1271, "maxX" : 1313, "minY" : 3270, "maxY" : 3327, "prop" : { "x" : 1271, "y" : 3296, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1275, "y" : 3301 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1307, "y" : 3301 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1307, "y" : 3301 } } }, "connectors" : [ { "edgeId" : 16366, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1289, "y" : 3293 }, "to" : { "x" : 1288, "y" : 3270 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1282, "y" : 3275 }, "b" : { "x" : 1294, "y" : 3287 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1288, "y" : 3281 } } }, "endShape" : { "a" : { "x" : 1285, "y" : 3286 }, "b" : { "x" : 1289, "y" : 3293 }, "c" : { "x" : 1293, "y" : 3286 }, "type" : "ARROW", "centre" : { "x" : 1293, "y" : 3286 } }, "isDisease" : true } ] }, { "id" : 16371, "reactomeId" : 9850939, "displayName" : "pY,pS STAT1, STAT3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1400, "y" : 3315 }, "minX" : 1288, "maxX" : 1448, "minY" : 3270, "maxY" : 3335, "prop" : { "x" : 1353, "y" : 3296, "width" : 95, "height" : 39 }, "textPosition" : { "x" : 1354, "y" : 3298 }, "connectors" : [ { "edgeId" : 16366, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1347, "y" : 3292 }, "to" : { "x" : 1288, "y" : 3270 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1339, "y" : 3293 }, "b" : { "x" : 1347, "y" : 3292 }, "c" : { "x" : 1342, "y" : 3286 }, "type" : "ARROW", "centre" : { "x" : 1342, "y" : 3286 } }, "isDisease" : true } ] }, { "id" : 14837, "reactomeId" : 9701805, "displayName" : "STAT5A gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1262, "y" : 1828 }, "minX" : 1219, "maxX" : 1321, "minY" : 1743, "maxY" : 1854, "prop" : { "x" : 1219, "y" : 1802, "width" : 87, "height" : 52 }, "textPosition" : { "x" : 1233, "y" : 1829 }, "connectors" : [ { "edgeId" : 16906, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1315, "y" : 1804 }, "to" : { "x" : 1321, "y" : 1743 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14846, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ], "endShape" : { "a" : { "x" : 1313, "y" : 1800 }, "b" : { "x" : 1306, "y" : 1804 }, "c" : { "x" : 1313, "y" : 1808 }, "type" : "ARROW", "centre" : { "x" : 1313, "y" : 1808 } } }, { "id" : 14838, "reactomeId" : 9005549, "displayName" : "MECP2", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1265, "y" : 1745 }, "minX" : 1241, "maxX" : 1321, "minY" : 1734, "maxY" : 1757, "prop" : { "x" : 1241, "y" : 1734, "width" : 49, "height" : 23 }, "textPosition" : { "x" : 1244, "y" : 1728 }, "connectors" : [ { "edgeId" : 16906, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1296, "y" : 1744 }, "to" : { "x" : 1321, "y" : 1743 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14839, "reactomeId" : 9701804, "displayName" : "MECP2:STAT5A gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1468, "y" : 1728 }, "minX" : 1413, "maxX" : 1530, "minY" : 1703, "maxY" : 1800, "prop" : { "x" : 1413, "y" : 1709, "width" : 111, "height" : 39 }, "textPosition" : { "x" : 1416, "y" : 1713 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1524, "y" : 1709 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1524, "y" : 1709 } } }, "connectors" : [ { "edgeId" : 16906, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 14846, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1455, "y" : 1751 }, "to" : { "x" : 1423, "y" : 1798 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1420, "y" : 1796 }, "b" : { "x" : 1426, "y" : 1800 }, "c" : { "x" : 1423, "y" : 1798 }, "type" : "STOP", "centre" : { "x" : 1423, "y" : 1798 } }, "isDisease" : true } ] }, { "id" : 14847, "reactomeId" : 9701901, "displayName" : "STAT5A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1495, "y" : 1807 }, "minX" : 1468, "maxX" : 1529, "minY" : 1790, "maxY" : 1819, "prop" : { "x" : 1468, "y" : 1796, "width" : 55, "height" : 23 }, "textPosition" : { "x" : 1468, "y" : 1797 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1523, "y" : 1796 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1523, "y" : 1796 } } }, "connectors" : [ { "edgeId" : 14846, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] } ], "edges" : [ { "id" : 15621, "reactomeId" : 9700120, "displayName" : "PTN and MDK bind to PTPRZ", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 113, "y" : 2275 }, "isFadeOut" : true, "minX" : 108, "maxX" : 182, "minY" : 2240, "maxY" : 2310, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 113, "y" : 2240 }, "to" : { "x" : 113, "y" : 2275 } }, { "from" : { "x" : 113, "y" : 2275 }, "to" : { "x" : 182, "y" : 2310 } } ], "endShape" : { "a" : { "x" : 174, "y" : 2310 }, "b" : { "x" : 182, "y" : 2310 }, "c" : { "x" : 178, "y" : 2303 }, "type" : "ARROW", "centre" : { "x" : 178, "y" : 2303 } }, "reactionShape" : { "c" : { "x" : 113, "y" : 2275 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 113, "y" : 2275 } }, "inputs" : [ { "id" : 15622, "points" : [ { "x" : 118, "y" : 2014 } ] }, { "id" : 109, "points" : [ { "x" : 159, "y" : 2226 } ] } ], "outputs" : [ { "id" : 114 } ] }, { "id" : 13574, "reactomeId" : 9700179, "displayName" : "Ligand-independent dimerization of ALK fusions", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1449, "y" : 767 }, "isDisease" : true, "minX" : 1404, "maxX" : 1467, "minY" : 762, "maxY" : 772, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1404, "y" : 768 }, "to" : { "x" : 1449, "y" : 767 } }, { "from" : { "x" : 1449, "y" : 767 }, "to" : { "x" : 1467, "y" : 766 } } ], "endShape" : { "a" : { "x" : 1460, "y" : 770 }, "b" : { "x" : 1467, "y" : 766 }, "c" : { "x" : 1460, "y" : 762 }, "type" : "ARROW", "centre" : { "x" : 1460, "y" : 762 } }, "reactionShape" : { "a" : { "x" : 1443, "y" : 761 }, "b" : { "x" : 1455, "y" : 773 }, "s" : "", "type" : "BOX", "empty" : true, "centre" : { "x" : 1449, "y" : 767 } }, "inputs" : [ { "id" : 13575, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 13576 } ] }, { "id" : 7, "reactomeId" : 201486, "displayName" : "ALK binds ligand pleiotrophin (PTN)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 248, "y" : 1740 }, "isFadeOut" : true, "minX" : 227, "maxX" : 265, "minY" : 1721, "maxY" : 1771, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 227, "y" : 1721 }, "to" : { "x" : 248, "y" : 1740 } }, { "from" : { "x" : 248, "y" : 1740 }, "to" : { "x" : 265, "y" : 1771 } } ], "endShape" : { "a" : { "x" : 258, "y" : 1767 }, "b" : { "x" : 265, "y" : 1771 }, "c" : { "x" : 265, "y" : 1763 }, "type" : "ARROW", "centre" : { "x" : 265, "y" : 1763 } }, "reactionShape" : { "c" : { "x" : 248, "y" : 1740 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 248, "y" : 1740 } }, "inputs" : [ { "id" : 8, "points" : [ { "x" : 194, "y" : 1716 } ] }, { "id" : 9, "points" : [ { "x" : 147, "y" : 106 }, { "x" : 120, "y" : 468 } ] } ], "outputs" : [ { "id" : 10 } ] }, { "id" : 14088, "reactomeId" : 9701531, "displayName" : "p-Y705,S727 STAT3 is acetylated", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1820, "y" : 1513 }, "isFadeOut" : true, "minX" : 1761, "maxX" : 1854, "minY" : 1507, "maxY" : 1519, "segments" : [ { "from" : { "x" : 1761, "y" : 1512 }, "to" : { "x" : 1820, "y" : 1513 } }, { "from" : { "x" : 1820, "y" : 1513 }, "to" : { "x" : 1854, "y" : 1512 } } ], "reactionShape" : { "a" : { "x" : 1814, "y" : 1507 }, "b" : { "x" : 1826, "y" : 1519 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1820, "y" : 1513 } }, "inputs" : [ { "id" : 13980, "points" : [ { "x" : 1685, "y" : 1497 } ] }, { "id" : 14034, "points" : [ { "x" : 1757, "y" : 1524 } ] } ], "outputs" : [ { "id" : 14015, "points" : [ { "x" : 1898, "y" : 1501 } ] }, { "id" : 14035, "points" : [ { "x" : 1889, "y" : 1540 } ] } ], "catalysts" : [ { "id" : 14036, "points" : [ { "x" : 1820, "y" : 1492 } ] } ] }, { "id" : 14089, "reactomeId" : 9701565, "displayName" : "HDACs deacetylate p-STAT3 dimers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1835, "y" : 1430 }, "isFadeOut" : true, "minX" : 1787, "maxX" : 1873, "minY" : 1424, "maxY" : 1436, "segments" : [ { "from" : { "x" : 1873, "y" : 1432 }, "to" : { "x" : 1835, "y" : 1430 } }, { "from" : { "x" : 1835, "y" : 1430 }, "to" : { "x" : 1787, "y" : 1430 } } ], "reactionShape" : { "a" : { "x" : 1829, "y" : 1424 }, "b" : { "x" : 1841, "y" : 1436 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1835, "y" : 1430 } }, "inputs" : [ { "id" : 14015, "points" : [ { "x" : 1923, "y" : 1458 } ] }, { "id" : 14090, "points" : [ { "x" : 1900, "y" : 1401 } ] } ], "outputs" : [ { "id" : 14054, "points" : [ { "x" : 1756, "y" : 1409 } ] }, { "id" : 13980, "points" : [ { "x" : 1681, "y" : 1468 } ] } ], "catalysts" : [ { "id" : 14087, "points" : [ { "x" : 1832, "y" : 1365 } ] } ] }, { "id" : 14601, "reactomeId" : 9712081, "displayName" : "ALK fusions bind FRS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1663, "y" : 507 }, "isDisease" : true, "minX" : 1606, "maxX" : 1706, "minY" : 502, "maxY" : 512, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1606, "y" : 509 }, "to" : { "x" : 1663, "y" : 507 } }, { "from" : { "x" : 1663, "y" : 507 }, "to" : { "x" : 1706, "y" : 509 } } ], "endShape" : { "a" : { "x" : 1699, "y" : 513 }, "b" : { "x" : 1706, "y" : 509 }, "c" : { "x" : 1699, "y" : 505 }, "type" : "ARROW", "centre" : { "x" : 1699, "y" : 505 } }, "reactionShape" : { "c" : { "x" : 1663, "y" : 507 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1663, "y" : 507 } }, "inputs" : [ { "id" : 15475, "points" : [ { "x" : 1510, "y" : 517 } ] }, { "id" : 14602, "points" : [ { "x" : 1578, "y" : 483 } ] } ], "outputs" : [ { "id" : 14607 } ] }, { "id" : 13577, "reactomeId" : 9700181, "displayName" : "Autophosphorylation of ALK fusions", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1660, "y" : 763 }, "isDisease" : true, "minX" : 1635, "maxX" : 1683, "minY" : 757, "maxY" : 769, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1635, "y" : 763 }, "to" : { "x" : 1660, "y" : 763 } }, { "from" : { "x" : 1660, "y" : 763 }, "to" : { "x" : 1683, "y" : 761 } } ], "reactionShape" : { "a" : { "x" : 1654, "y" : 757 }, "b" : { "x" : 1666, "y" : 769 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1660, "y" : 763 } }, "inputs" : [ { "id" : 13578, "points" : [ { "x" : 1615, "y" : 787 } ], "stoichiometry" : 3 }, { "id" : 13576, "points" : [ { "x" : 1597, "y" : 764 } ] } ], "outputs" : [ { "id" : 13579, "points" : [ { "x" : 1706, "y" : 760 } ] }, { "id" : 13580, "points" : [ { "x" : 1706, "y" : 805 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 13576, "points" : [ { "x" : 1588, "y" : 742 }, { "x" : 1624, "y" : 736 } ] } ] }, { "id" : 15625, "reactomeId" : 9850958, "displayName" : "pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1229, "y" : 1661 }, "isDisease" : true, "minX" : 968, "maxX" : 1590, "minY" : 1511, "maxY" : 1748, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 968, "y" : 1748 }, "to" : { "x" : 1229, "y" : 1661 } }, { "from" : { "x" : 1229, "y" : 1661 }, "to" : { "x" : 1590, "y" : 1511 } } ], "endShape" : { "a" : { "x" : 1585, "y" : 1517 }, "b" : { "x" : 1590, "y" : 1511 }, "c" : { "x" : 1582, "y" : 1510 }, "type" : "ARROW", "centre" : { "x" : 1582, "y" : 1510 } }, "reactionShape" : { "a" : { "x" : 1223, "y" : 1655 }, "b" : { "x" : 1235, "y" : 1667 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1229, "y" : 1661 } }, "inputs" : [ { "id" : 14782 } ], "outputs" : [ { "id" : 13980 } ] }, { "id" : 16906, "reactomeId" : 9701810, "displayName" : "MECP2 binds the STAT5A gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1348, "y" : 1741 }, "isDisease" : true, "minX" : 1321, "maxX" : 1410, "minY" : 1734, "maxY" : 1746, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1321, "y" : 1743 }, "to" : { "x" : 1348, "y" : 1741 } }, { "from" : { "x" : 1348, "y" : 1741 }, "to" : { "x" : 1410, "y" : 1734 } } ], "endShape" : { "a" : { "x" : 1404, "y" : 1739 }, "b" : { "x" : 1410, "y" : 1734 }, "c" : { "x" : 1403, "y" : 1731 }, "type" : "ARROW", "centre" : { "x" : 1403, "y" : 1731 } }, "reactionShape" : { "c" : { "x" : 1348, "y" : 1741 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1348, "y" : 1741 } }, "inputs" : [ { "id" : 14837, "points" : [ { "x" : 1315, "y" : 1804 } ] }, { "id" : 14838, "points" : [ { "x" : 1296, "y" : 1744 } ] } ], "outputs" : [ { "id" : 14839 } ], "activators" : [ { "id" : 13980, "points" : [ { "x" : 1613, "y" : 1511 } ] } ] }, { "id" : 16394, "reactomeId" : 9851078, "displayName" : "NPM1-ALK-dependent MAPK8,9 phosphorylation", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1091, "y" : 2720 }, "isDisease" : true, "minX" : 1072, "maxX" : 1113, "minY" : 2714, "maxY" : 2726, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1072, "y" : 2717 }, "to" : { "x" : 1091, "y" : 2720 } }, { "from" : { "x" : 1091, "y" : 2720 }, "to" : { "x" : 1113, "y" : 2719 } } ], "reactionShape" : { "a" : { "x" : 1085, "y" : 2714 }, "b" : { "x" : 1097, "y" : 2726 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1091, "y" : 2720 } }, "inputs" : [ { "id" : 16395, "points" : [ { "x" : 1055, "y" : 2704 } ] }, { "id" : 16396, "points" : [ { "x" : 1047, "y" : 2739 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 16438, "points" : [ { "x" : 1130, "y" : 2687 } ], "stoichiometry" : 2 }, { "id" : 16439, "points" : [ { "x" : 1113, "y" : 2895 } ] } ], "activators" : [ { "id" : 15275, "points" : [ { "x" : 1075, "y" : 2563 } ] } ] }, { "id" : 15883, "reactomeId" : 9851062, "displayName" : "AcK685 pY705,S727 STAT3 binds the MIR21 gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2417, "y" : 1835 }, "isDisease" : true, "minX" : 2186, "maxX" : 2484, "minY" : 1830, "maxY" : 1868, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2186, "y" : 1868 }, "to" : { "x" : 2417, "y" : 1835 } }, { "from" : { "x" : 2417, "y" : 1835 }, "to" : { "x" : 2484, "y" : 1835 } } ], "endShape" : { "a" : { "x" : 2477, "y" : 1839 }, "b" : { "x" : 2484, "y" : 1835 }, "c" : { "x" : 2477, "y" : 1831 }, "type" : "ARROW", "centre" : { "x" : 2477, "y" : 1831 } }, "reactionShape" : { "c" : { "x" : 2417, "y" : 1835 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2417, "y" : 1835 } }, "inputs" : [ { "id" : 15884, "points" : [ { "x" : 2193, "y" : 1921 } ] }, { "id" : 14015, "points" : [ { "x" : 1966, "y" : 1501 } ] } ], "outputs" : [ { "id" : 15885 } ] }, { "id" : 14091, "reactomeId" : 9701549, "displayName" : "AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2145, "y" : 1382 }, "isFadeOut" : true, "minX" : 2096, "maxX" : 2185, "minY" : 1360, "maxY" : 1387, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 2096, "y" : 1360 }, "to" : { "x" : 2145, "y" : 1382 } }, { "from" : { "x" : 2145, "y" : 1382 }, "to" : { "x" : 2185, "y" : 1384 } } ], "endShape" : { "a" : { "x" : 2178, "y" : 1388 }, "b" : { "x" : 2185, "y" : 1384 }, "c" : { "x" : 2178, "y" : 1380 }, "type" : "ARROW", "centre" : { "x" : 2178, "y" : 1380 } }, "reactionShape" : { "c" : { "x" : 2145, "y" : 1382 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2145, "y" : 1382 } }, "inputs" : [ { "id" : 14015, "points" : [ { "x" : 1977, "y" : 1458 } ] }, { "id" : 14017, "points" : [ { "x" : 2048, "y" : 1303 } ] }, { "id" : 14016, "points" : [ { "x" : 2067, "y" : 1412 } ] } ], "outputs" : [ { "id" : 14018 } ] }, { "id" : 17163, "reactomeId" : 9851077, "displayName" : "JNK-dependent inhibition of TP53 ubiquitination", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1675, "y" : 2724 }, "isDisease" : true, "minX" : 1626, "maxX" : 1741, "minY" : 2718, "maxY" : 2730, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1626, "y" : 2723 }, "to" : { "x" : 1675, "y" : 2724 } }, { "from" : { "x" : 1675, "y" : 2724 }, "to" : { "x" : 1741, "y" : 2725 } } ], "endShape" : { "a" : { "x" : 1734, "y" : 2729 }, "b" : { "x" : 1741, "y" : 2725 }, "c" : { "x" : 1734, "y" : 2721 }, "type" : "ARROW", "centre" : { "x" : 1734, "y" : 2721 } }, "reactionShape" : { "a" : { "x" : 1669, "y" : 2718 }, "b" : { "x" : 1681, "y" : 2730 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1675, "y" : 2724 } }, "inputs" : [ { "id" : 16659 } ], "outputs" : [ { "id" : 16769 } ], "activators" : [ { "id" : 16664, "points" : [ { "x" : 1696, "y" : 2783 } ] } ] }, { "id" : 11, "reactomeId" : 9667914, "displayName" : "ALK binds ligand midkine (MDK)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 165, "y" : 1788 }, "isFadeOut" : true, "minX" : 141, "maxX" : 199, "minY" : 1732, "maxY" : 1809, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 141, "y" : 1732 }, "to" : { "x" : 165, "y" : 1788 } }, { "from" : { "x" : 165, "y" : 1788 }, "to" : { "x" : 199, "y" : 1809 } } ], "endShape" : { "a" : { "x" : 191, "y" : 1809 }, "b" : { "x" : 199, "y" : 1809 }, "c" : { "x" : 195, "y" : 1802 }, "type" : "ARROW", "centre" : { "x" : 195, "y" : 1802 } }, "reactionShape" : { "c" : { "x" : 165, "y" : 1788 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 165, "y" : 1788 } }, "inputs" : [ { "id" : 12, "points" : [ { "x" : 125, "y" : 1722 } ] }, { "id" : 9, "points" : [ { "x" : 144, "y" : 106 }, { "x" : 76, "y" : 334 }, { "x" : 102, "y" : 1558 } ] } ], "outputs" : [ { "id" : 13 } ] }, { "id" : 14092, "reactomeId" : 9701548, "displayName" : "PRDM1 gene expression downstream of ALK signaling", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2216, "y" : 1315 }, "isFadeOut" : true, "minX" : 2048, "maxX" : 2315, "minY" : 1303, "maxY" : 1322, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 2048, "y" : 1303 }, "to" : { "x" : 2216, "y" : 1315 } }, { "from" : { "x" : 2216, "y" : 1315 }, "to" : { "x" : 2315, "y" : 1322 } } ], "endShape" : { "a" : { "x" : 2308, "y" : 1326 }, "b" : { "x" : 2315, "y" : 1322 }, "c" : { "x" : 2308, "y" : 1318 }, "type" : "ARROW", "centre" : { "x" : 2308, "y" : 1318 } }, "reactionShape" : { "a" : { "x" : 2210, "y" : 1309 }, "b" : { "x" : 2222, "y" : 1321 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2216, "y" : 1315 } }, "inputs" : [ { "id" : 14017 } ], "outputs" : [ { "id" : 14020 } ], "inhibitors" : [ { "id" : 14018, "points" : [ { "x" : 2241, "y" : 1360 } ] } ] }, { "id" : 14094, "reactomeId" : 9701556, "displayName" : "IL2RG gene expression downstream of ALK signaling", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2538, "y" : 1499 }, "isFadeOut" : true, "minX" : 2191, "maxX" : 2957, "minY" : 1474, "maxY" : 1505, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 2191, "y" : 1474 }, "to" : { "x" : 2538, "y" : 1499 } }, { "from" : { "x" : 2538, "y" : 1499 }, "to" : { "x" : 2957, "y" : 1494 } } ], "endShape" : { "a" : { "x" : 2950, "y" : 1498 }, "b" : { "x" : 2957, "y" : 1494 }, "c" : { "x" : 2950, "y" : 1490 }, "type" : "ARROW", "centre" : { "x" : 2950, "y" : 1490 } }, "reactionShape" : { "a" : { "x" : 2532, "y" : 1493 }, "b" : { "x" : 2544, "y" : 1505 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2538, "y" : 1499 } }, "inputs" : [ { "id" : 14069 } ], "outputs" : [ { "id" : 14078 } ], "inhibitors" : [ { "id" : 14070, "points" : [ { "x" : 2533, "y" : 1464 } ] }, { "id" : 15838, "points" : [ { "x" : 2538, "y" : 1551 } ] } ] }, { "id" : 14095, "reactomeId" : 9701534, "displayName" : "p-Y705, S727 STAT3 dimer binds HIF1A gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1430, "y" : 1335 }, "isFadeOut" : true, "minX" : 1425, "maxX" : 1501, "minY" : 1201, "maxY" : 1381, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1460, "y" : 1381 }, "to" : { "x" : 1430, "y" : 1335 } }, { "from" : { "x" : 1430, "y" : 1335 }, "to" : { "x" : 1501, "y" : 1201 } } ], "endShape" : { "a" : { "x" : 1501, "y" : 1209 }, "b" : { "x" : 1501, "y" : 1201 }, "c" : { "x" : 1494, "y" : 1205 }, "type" : "ARROW", "centre" : { "x" : 1494, "y" : 1205 } }, "reactionShape" : { "c" : { "x" : 1430, "y" : 1335 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1430, "y" : 1335 } }, "inputs" : [ { "id" : 13980, "points" : [ { "x" : 1604, "y" : 1468 } ] }, { "id" : 14083, "points" : [ { "x" : 1599, "y" : 1305 }, { "x" : 1540, "y" : 1285 }, { "x" : 1492, "y" : 1288 } ] } ], "outputs" : [ { "id" : 14084 } ] }, { "id" : 14608, "reactomeId" : 9712087, "displayName" : "ALK fusions phosphorylate FRS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1861, "y" : 514 }, "isDisease" : true, "minX" : 1843, "maxX" : 1877, "minY" : 508, "maxY" : 520, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1843, "y" : 515 }, "to" : { "x" : 1861, "y" : 514 } }, { "from" : { "x" : 1861, "y" : 514 }, "to" : { "x" : 1877, "y" : 512 } } ], "reactionShape" : { "a" : { "x" : 1855, "y" : 508 }, "b" : { "x" : 1867, "y" : 520 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1861, "y" : 514 } }, "inputs" : [ { "id" : 14607, "points" : [ { "x" : 1811, "y" : 514 } ] }, { "id" : 14711, "points" : [ { "x" : 1781, "y" : 476 } ], "stoichiometry" : 6 } ], "outputs" : [ { "id" : 14611, "points" : [ { "x" : 1950, "y" : 513 } ] }, { "id" : 14712, "points" : [ { "x" : 1871, "y" : 473 } ], "stoichiometry" : 6 } ], "catalysts" : [ { "id" : 14607, "points" : [ { "x" : 1789, "y" : 528 }, { "x" : 1849, "y" : 546 } ] } ] }, { "id" : 14096, "reactomeId" : 9701569, "displayName" : "ALK- and STAT3-dependent HIF1A gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1630, "y" : 1317 }, "isFadeOut" : true, "minX" : 1599, "maxX" : 1656, "minY" : 1305, "maxY" : 1323, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 1599, "y" : 1305 }, "to" : { "x" : 1630, "y" : 1317 } }, { "from" : { "x" : 1630, "y" : 1317 }, "to" : { "x" : 1656, "y" : 1317 } } ], "endShape" : { "a" : { "x" : 1649, "y" : 1321 }, "b" : { "x" : 1656, "y" : 1317 }, "c" : { "x" : 1649, "y" : 1313 }, "type" : "ARROW", "centre" : { "x" : 1649, "y" : 1313 } }, "reactionShape" : { "a" : { "x" : 1624, "y" : 1311 }, "b" : { "x" : 1636, "y" : 1323 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1630, "y" : 1317 } }, "inputs" : [ { "id" : 14083 } ], "outputs" : [ { "id" : 14086 } ], "activators" : [ { "id" : 14084, "points" : [ { "x" : 1566, "y" : 1201 }, { "x" : 1621, "y" : 1225 } ] } ] }, { "id" : 13584, "reactomeId" : 9700184, "displayName" : "Ligand-independent dimerization of point mutants of ALK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 441, "y" : 27 }, "isDisease" : true, "minX" : 367, "maxX" : 519, "minY" : 22, "maxY" : 54, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 367, "y" : 54 }, "to" : { "x" : 441, "y" : 27 } }, { "from" : { "x" : 441, "y" : 27 }, "to" : { "x" : 519, "y" : 49 } } ], "endShape" : { "a" : { "x" : 511, "y" : 51 }, "b" : { "x" : 519, "y" : 49 }, "c" : { "x" : 513, "y" : 43 }, "type" : "ARROW", "centre" : { "x" : 513, "y" : 43 } }, "reactionShape" : { "a" : { "x" : 435, "y" : 21 }, "b" : { "x" : 447, "y" : 33 }, "s" : "", "type" : "BOX", "empty" : true, "centre" : { "x" : 441, "y" : 27 } }, "inputs" : [ { "id" : 13612, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 13614 } ] }, { "id" : 14097, "reactomeId" : 9701537, "displayName" : "p-Y705, S727 STAT3 dimer binds CD274 gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2102, "y" : 1183 }, "isFadeOut" : true, "minX" : 2031, "maxX" : 2152, "minY" : 1178, "maxY" : 1188, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 2031, "y" : 1183 }, "to" : { "x" : 2102, "y" : 1183 } }, { "from" : { "x" : 2102, "y" : 1183 }, "to" : { "x" : 2152, "y" : 1180 } } ], "endShape" : { "a" : { "x" : 2145, "y" : 1184 }, "b" : { "x" : 2152, "y" : 1180 }, "c" : { "x" : 2145, "y" : 1176 }, "type" : "ARROW", "centre" : { "x" : 2145, "y" : 1176 } }, "reactionShape" : { "c" : { "x" : 2102, "y" : 1183 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2102, "y" : 1183 } }, "inputs" : [ { "id" : 14098, "points" : [ { "x" : 1993, "y" : 1229 } ] }, { "id" : 13980, "points" : [ { "x" : 1644, "y" : 1468 }, { "x" : 1807, "y" : 1181 } ] } ], "outputs" : [ { "id" : 14099 } ] }, { "id" : 15890, "reactomeId" : 9851139, "displayName" : "STAT3-dependent MIR-21 gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2538, "y" : 1893 }, "isDisease" : true, "minX" : 2193, "maxX" : 2798, "minY" : 1887, "maxY" : 1921, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2193, "y" : 1921 }, "to" : { "x" : 2538, "y" : 1893 } }, { "from" : { "x" : 2538, "y" : 1893 }, "to" : { "x" : 2798, "y" : 1895 } } ], "endShape" : { "a" : { "x" : 2791, "y" : 1899 }, "b" : { "x" : 2798, "y" : 1895 }, "c" : { "x" : 2791, "y" : 1891 }, "type" : "ARROW", "centre" : { "x" : 2791, "y" : 1891 } }, "reactionShape" : { "a" : { "x" : 2532, "y" : 1887 }, "b" : { "x" : 2544, "y" : 1899 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2538, "y" : 1893 } }, "inputs" : [ { "id" : 15884 } ], "outputs" : [ { "id" : 15891 } ], "inhibitors" : [ { "id" : 15885, "points" : [ { "x" : 2542, "y" : 1865 } ] } ] }, { "id" : 13587, "reactomeId" : 9700190, "displayName" : "ALK mutants bind SHC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1737, "y" : 590 }, "isDisease" : true, "minX" : 1717, "maxX" : 1765, "minY" : 585, "maxY" : 614, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1717, "y" : 586 }, "to" : { "x" : 1737, "y" : 590 } }, { "from" : { "x" : 1737, "y" : 590 }, "to" : { "x" : 1765, "y" : 614 } } ], "endShape" : { "a" : { "x" : 1757, "y" : 613 }, "b" : { "x" : 1765, "y" : 614 }, "c" : { "x" : 1762, "y" : 606 }, "type" : "ARROW", "centre" : { "x" : 1762, "y" : 606 } }, "reactionShape" : { "c" : { "x" : 1737, "y" : 590 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1737, "y" : 590 } }, "inputs" : [ { "id" : 14784, "points" : [ { "x" : 1681, "y" : 608 } ] }, { "id" : 182, "points" : [ { "x" : 1386, "y" : 447 } ] } ], "outputs" : [ { "id" : 13588 } ] }, { "id" : 14100, "reactomeId" : 9701562, "displayName" : "CD274 gene expression downstream of ALK signaling", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2230, "y" : 1244 }, "isFadeOut" : true, "minX" : 1993, "maxX" : 2952, "minY" : 1229, "maxY" : 1250, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 1993, "y" : 1229 }, "to" : { "x" : 2230, "y" : 1244 } }, { "from" : { "x" : 2230, "y" : 1244 }, "to" : { "x" : 2952, "y" : 1246 } } ], "endShape" : { "a" : { "x" : 2945, "y" : 1250 }, "b" : { "x" : 2952, "y" : 1246 }, "c" : { "x" : 2945, "y" : 1242 }, "type" : "ARROW", "centre" : { "x" : 2945, "y" : 1242 } }, "reactionShape" : { "a" : { "x" : 2224, "y" : 1238 }, "b" : { "x" : 2236, "y" : 1250 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2230, "y" : 1244 } }, "inputs" : [ { "id" : 14098 } ], "outputs" : [ { "id" : 14101 } ], "activators" : [ { "id" : 14099, "points" : [ { "x" : 2225, "y" : 1207 } ] } ] }, { "id" : 13589, "reactomeId" : 9700193, "displayName" : "ALK mutants phosphorylate SHC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1892, "y" : 632 }, "isDisease" : true, "minX" : 1873, "maxX" : 1909, "minY" : 625, "maxY" : 638, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1873, "y" : 633 }, "to" : { "x" : 1892, "y" : 632 } }, { "from" : { "x" : 1892, "y" : 632 }, "to" : { "x" : 1909, "y" : 625 } } ], "reactionShape" : { "a" : { "x" : 1886, "y" : 626 }, "b" : { "x" : 1898, "y" : 638 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1892, "y" : 632 } }, "inputs" : [ { "id" : 13590, "points" : [ { "x" : 1852, "y" : 668 } ], "stoichiometry" : 3 }, { "id" : 13588, "points" : [ { "x" : 1850, "y" : 633 } ] } ], "outputs" : [ { "id" : 13592, "points" : [ { "x" : 1932, "y" : 662 } ], "stoichiometry" : 3 }, { "id" : 13591, "points" : [ { "x" : 1931, "y" : 623 } ] } ], "catalysts" : [ { "id" : 13588, "points" : [ { "x" : 1820, "y" : 614 }, { "x" : 1870, "y" : 591 } ] } ] }, { "id" : 14872, "reactomeId" : 9724090, "displayName" : "MYH9- and RNF213-ALK fusions are phosphorylated", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1503, "y" : 946 }, "isDisease" : true, "minX" : 1472, "maxX" : 1512, "minY" : 940, "maxY" : 952, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1472, "y" : 943 }, "to" : { "x" : 1503, "y" : 946 } }, { "from" : { "x" : 1503, "y" : 946 }, "to" : { "x" : 1512, "y" : 946 } } ], "endShape" : { "a" : { "x" : 1505, "y" : 950 }, "b" : { "x" : 1512, "y" : 946 }, "c" : { "x" : 1505, "y" : 942 }, "type" : "ARROW", "centre" : { "x" : 1505, "y" : 942 } }, "reactionShape" : { "a" : { "x" : 1497, "y" : 940 }, "b" : { "x" : 1509, "y" : 952 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1503, "y" : 946 } }, "inputs" : [ { "id" : 14873 } ], "outputs" : [ { "id" : 14874 } ] }, { "id" : 17176, "reactomeId" : 9851127, "displayName" : "NPM1-ALK-dependent repression of pRB phosphorylation", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1327, "y" : 2333 }, "isDisease" : true, "minX" : 1289, "maxX" : 1392, "minY" : 2327, "maxY" : 2339, "reactionType" : "uncertain", "segments" : [ { "from" : { "x" : 1289, "y" : 2335 }, "to" : { "x" : 1327, "y" : 2333 } }, { "from" : { "x" : 1327, "y" : 2333 }, "to" : { "x" : 1392, "y" : 2332 } } ], "endShape" : { "a" : { "x" : 1385, "y" : 2336 }, "b" : { "x" : 1392, "y" : 2332 }, "c" : { "x" : 1385, "y" : 2328 }, "type" : "ARROW", "centre" : { "x" : 1385, "y" : 2328 } }, "reactionShape" : { "a" : { "x" : 1321, "y" : 2327 }, "b" : { "x" : 1333, "y" : 2339 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 1327, "y" : 2333 } }, "inputs" : [ { "id" : 17177 } ], "outputs" : [ { "id" : 17178 } ], "inhibitors" : [ { "id" : 15260, "points" : [ { "x" : 1346, "y" : 2503 } ] } ] }, { "id" : 27, "reactomeId" : 201519, "displayName" : "ALK:PTN dimerization", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 281, "y" : 2004 }, "isFadeOut" : true, "minX" : 276, "maxX" : 318, "minY" : 1978, "maxY" : 2078, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 277, "y" : 1978 }, "to" : { "x" : 281, "y" : 2004 } }, { "from" : { "x" : 281, "y" : 2004 }, "to" : { "x" : 318, "y" : 2078 } } ], "endShape" : { "a" : { "x" : 311, "y" : 2074 }, "b" : { "x" : 318, "y" : 2078 }, "c" : { "x" : 318, "y" : 2070 }, "type" : "ARROW", "centre" : { "x" : 318, "y" : 2070 } }, "reactionShape" : { "c" : { "x" : 281, "y" : 2004 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 281, "y" : 2004 } }, "inputs" : [ { "id" : 10, "points" : [ { "x" : 271, "y" : 1800 }, { "x" : 278, "y" : 1918 } ] }, { "id" : 15587, "points" : [ { "x" : 208, "y" : 1924 } ] } ], "outputs" : [ { "id" : 28 } ] }, { "id" : 13596, "reactomeId" : 9700186, "displayName" : "Autophosphorylation of point mutants of ALK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 704, "y" : 52 }, "isDisease" : true, "minX" : 674, "maxX" : 737, "minY" : 46, "maxY" : 58, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 674, "y" : 53 }, "to" : { "x" : 704, "y" : 52 } }, { "from" : { "x" : 704, "y" : 52 }, "to" : { "x" : 737, "y" : 50 } } ], "reactionShape" : { "a" : { "x" : 698, "y" : 46 }, "b" : { "x" : 710, "y" : 58 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 704, "y" : 52 } }, "inputs" : [ { "id" : 13618, "points" : [ { "x" : 663, "y" : 105 } ], "stoichiometry" : 14 }, { "id" : 13614, "points" : [ { "x" : 634, "y" : 62 } ] } ], "outputs" : [ { "id" : 13621, "points" : [ { "x" : 788, "y" : 96 } ], "stoichiometry" : 14 }, { "id" : 13622, "points" : [ { "x" : 818, "y" : 58 } ] } ], "catalysts" : [ { "id" : 13614, "points" : [ { "x" : 599, "y" : 49 }, { "x" : 681, "y" : 0 } ] } ] }, { "id" : 29, "reactomeId" : 9700137, "displayName" : "ALK:MDK dimerization", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 208, "y" : 2058 }, "isFadeOut" : true, "minX" : 203, "maxX" : 222, "minY" : 2023, "maxY" : 2107, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 206, "y" : 2023 }, "to" : { "x" : 208, "y" : 2058 } }, { "from" : { "x" : 208, "y" : 2058 }, "to" : { "x" : 222, "y" : 2107 } } ], "endShape" : { "a" : { "x" : 216, "y" : 2101 }, "b" : { "x" : 222, "y" : 2107 }, "c" : { "x" : 224, "y" : 2099 }, "type" : "ARROW", "centre" : { "x" : 224, "y" : 2099 } }, "reactionShape" : { "c" : { "x" : 208, "y" : 2058 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 208, "y" : 2058 } }, "inputs" : [ { "id" : 13, "points" : [ { "x" : 208, "y" : 1838 }, { "x" : 144, "y" : 1935 } ] }, { "id" : 15587, "points" : [ { "x" : 190, "y" : 1928 } ] } ], "outputs" : [ { "id" : 30 } ] }, { "id" : 16419, "reactomeId" : 9851096, "displayName" : "NPM1-ALK- and JNK-dependent JUN phosphorylation", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1433, "y" : 2914 }, "isDisease" : true, "minX" : 1427, "maxX" : 1439, "minY" : 2891, "maxY" : 2933, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1433, "y" : 2933 }, "to" : { "x" : 1433, "y" : 2914 } }, { "from" : { "x" : 1433, "y" : 2914 }, "to" : { "x" : 1433, "y" : 2891 } } ], "reactionShape" : { "a" : { "x" : 1427, "y" : 2908 }, "b" : { "x" : 1439, "y" : 2920 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1433, "y" : 2914 } }, "inputs" : [ { "id" : 16424, "points" : [ { "x" : 1405, "y" : 2957 } ], "stoichiometry" : 2 }, { "id" : 16425, "points" : [ { "x" : 1455, "y" : 2958 } ] } ], "outputs" : [ { "id" : 16421, "points" : [ { "x" : 1605, "y" : 2882 } ] }, { "id" : 16422, "points" : [ { "x" : 1400, "y" : 2863 } ], "stoichiometry" : 2 } ], "activators" : [ { "id" : 16398, "points" : [ { "x" : 1327, "y" : 2916 } ] } ] }, { "id" : 15653, "reactomeId" : 9851104, "displayName" : "NPM1-ALK- and STAT3-dependent ICOS gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2422, "y" : 2238 }, "isDisease" : true, "minX" : 2233, "maxX" : 2945, "minY" : 2232, "maxY" : 2264, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2233, "y" : 2253 }, "to" : { "x" : 2422, "y" : 2238 } }, { "from" : { "x" : 2422, "y" : 2238 }, "to" : { "x" : 2945, "y" : 2264 } } ], "endShape" : { "a" : { "x" : 2938, "y" : 2268 }, "b" : { "x" : 2945, "y" : 2264 }, "c" : { "x" : 2938, "y" : 2260 }, "type" : "ARROW", "centre" : { "x" : 2938, "y" : 2260 } }, "reactionShape" : { "a" : { "x" : 2416, "y" : 2232 }, "b" : { "x" : 2428, "y" : 2244 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2422, "y" : 2238 } }, "inputs" : [ { "id" : 15631 } ], "outputs" : [ { "id" : 15654 } ], "activators" : [ { "id" : 15632, "points" : [ { "x" : 2250, "y" : 2160 } ] } ] }, { "id" : 15909, "reactomeId" : 9851145, "displayName" : "Translation of DNMT1 mRNA is repressed by miR-21", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2569, "y" : 1656 }, "isDisease" : true, "minX" : 2244, "maxX" : 2746, "minY" : 1644, "maxY" : 1687, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2746, "y" : 1687 }, "to" : { "x" : 2569, "y" : 1656 } }, { "from" : { "x" : 2569, "y" : 1656 }, "to" : { "x" : 2244, "y" : 1644 } } ], "endShape" : { "a" : { "x" : 2251, "y" : 1640 }, "b" : { "x" : 2244, "y" : 1644 }, "c" : { "x" : 2251, "y" : 1648 }, "type" : "ARROW", "centre" : { "x" : 2251, "y" : 1648 } }, "reactionShape" : { "a" : { "x" : 2563, "y" : 1650 }, "b" : { "x" : 2575, "y" : 1662 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2569, "y" : 1656 } }, "inputs" : [ { "id" : 15910 } ], "outputs" : [ { "id" : 15844 } ], "inhibitors" : [ { "id" : 15911, "points" : [ { "x" : 2787, "y" : 1583 } ] } ] }, { "id" : 295, "reactomeId" : 201515, "displayName" : "Active ALK recruits PI3K", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 457, "y" : 339 }, "isFadeOut" : true, "minX" : 264, "maxX" : 712, "minY" : 333, "maxY" : 345, "reactionType" : "Uncertain Process", "segments" : [ { "from" : { "x" : 712, "y" : 337 }, "to" : { "x" : 457, "y" : 339 } }, { "from" : { "x" : 457, "y" : 339 }, "to" : { "x" : 264, "y" : 338 } } ], "endShape" : { "a" : { "x" : 271, "y" : 334 }, "b" : { "x" : 264, "y" : 338 }, "c" : { "x" : 271, "y" : 342 }, "type" : "ARROW", "centre" : { "x" : 271, "y" : 342 } }, "reactionShape" : { "a" : { "x" : 451, "y" : 333 }, "b" : { "x" : 463, "y" : 345 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 457, "y" : 339 } }, "inputs" : [ { "id" : 296, "points" : [ { "x" : 786, "y" : 344 } ] }, { "id" : 15541, "points" : [ { "x" : 1176, "y" : 216 } ] } ], "outputs" : [ { "id" : 297 } ] }, { "id" : 15912, "reactomeId" : 9851147, "displayName" : "miR-21 RISC binds DNMT1 mRNA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2912, "y" : 1768 }, "isDisease" : true, "minX" : 2846, "maxX" : 2917, "minY" : 1583, "maxY" : 1823, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2866, "y" : 1823 }, "to" : { "x" : 2912, "y" : 1768 } }, { "from" : { "x" : 2912, "y" : 1768 }, "to" : { "x" : 2846, "y" : 1583 } } ], "endShape" : { "a" : { "x" : 2852, "y" : 1588 }, "b" : { "x" : 2846, "y" : 1583 }, "c" : { "x" : 2845, "y" : 1591 }, "type" : "ARROW", "centre" : { "x" : 2845, "y" : 1591 } }, "reactionShape" : { "c" : { "x" : 2912, "y" : 1768 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2912, "y" : 1768 } }, "inputs" : [ { "id" : 15910, "points" : [ { "x" : 2819, "y" : 1714 } ] }, { "id" : 15891, "points" : [ { "x" : 2845, "y" : 1879 } ] } ], "outputs" : [ { "id" : 15911 } ] }, { "id" : 16682, "reactomeId" : 9851076, "displayName" : "p-T,Y MAPK8,9 bind TP53", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1621, "y" : 2806 }, "isDisease" : true, "minX" : 1595, "maxX" : 1648, "minY" : 2801, "maxY" : 2811, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1595, "y" : 2807 }, "to" : { "x" : 1621, "y" : 2806 } }, { "from" : { "x" : 1621, "y" : 2806 }, "to" : { "x" : 1648, "y" : 2805 } } ], "endShape" : { "a" : { "x" : 1641, "y" : 2809 }, "b" : { "x" : 1648, "y" : 2805 }, "c" : { "x" : 1641, "y" : 2801 }, "type" : "ARROW", "centre" : { "x" : 1641, "y" : 2801 } }, "reactionShape" : { "c" : { "x" : 1621, "y" : 2806 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1621, "y" : 2806 } }, "inputs" : [ { "id" : 16398, "points" : [ { "x" : 1291, "y" : 2897 }, { "x" : 1388, "y" : 2803 } ] }, { "id" : 16659, "points" : [ { "x" : 1577, "y" : 2746 } ] } ], "outputs" : [ { "id" : 16664 } ] }, { "id" : 16430, "reactomeId" : 9851098, "displayName" : "NPM1-ALK- and JUN-dependent CDKN1A gene repression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1734, "y" : 2919 }, "isDisease" : true, "minX" : 1705, "maxX" : 1762, "minY" : 2913, "maxY" : 2925, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1705, "y" : 2919 }, "to" : { "x" : 1734, "y" : 2919 } }, { "from" : { "x" : 1734, "y" : 2919 }, "to" : { "x" : 1762, "y" : 2919 } } ], "endShape" : { "a" : { "x" : 1755, "y" : 2923 }, "b" : { "x" : 1762, "y" : 2919 }, "c" : { "x" : 1755, "y" : 2915 }, "type" : "ARROW", "centre" : { "x" : 1755, "y" : 2915 } }, "reactionShape" : { "a" : { "x" : 1728, "y" : 2913 }, "b" : { "x" : 1740, "y" : 2925 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1734, "y" : 2919 } }, "inputs" : [ { "id" : 16431 } ], "outputs" : [ { "id" : 16432 } ], "inhibitors" : [ { "id" : 16421, "points" : [ { "x" : 1686, "y" : 2897 } ] } ] }, { "id" : 15408, "reactomeId" : 9725342, "displayName" : "NPM1-ALK-dependent JUNB gene transcription", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1896, "y" : 2608 }, "isDisease" : true, "minX" : 1812, "maxX" : 2747, "minY" : 2593, "maxY" : 2614, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1812, "y" : 2604 }, "to" : { "x" : 1896, "y" : 2608 } }, { "from" : { "x" : 1896, "y" : 2608 }, "to" : { "x" : 2747, "y" : 2593 } } ], "endShape" : { "a" : { "x" : 2740, "y" : 2597 }, "b" : { "x" : 2747, "y" : 2593 }, "c" : { "x" : 2740, "y" : 2589 }, "type" : "ARROW", "centre" : { "x" : 2740, "y" : 2589 } }, "reactionShape" : { "a" : { "x" : 1890, "y" : 2602 }, "b" : { "x" : 1902, "y" : 2614 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1896, "y" : 2608 } }, "inputs" : [ { "id" : 15409 } ], "outputs" : [ { "id" : 15434 } ], "activators" : [ { "id" : 15413, "points" : [ { "x" : 1979, "y" : 2579 } ] }, { "id" : 15260, "points" : [ { "x" : 1418, "y" : 2535 }, { "x" : 1802, "y" : 2560 } ] } ] }, { "id" : 307, "reactomeId" : 201510, "displayName" : "PI3K synthesizes PIP3 downstream of ALK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 247, "y" : 489 }, "isFadeOut" : true, "minX" : 241, "maxX" : 253, "minY" : 455, "maxY" : 509, "segments" : [ { "from" : { "x" : 243, "y" : 455 }, "to" : { "x" : 247, "y" : 489 } }, { "from" : { "x" : 247, "y" : 489 }, "to" : { "x" : 248, "y" : 509 } } ], "reactionShape" : { "a" : { "x" : 241, "y" : 483 }, "b" : { "x" : 253, "y" : 495 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 247, "y" : 489 } }, "inputs" : [ { "id" : 14466, "points" : [ { "x" : 250, "y" : 413 } ] }, { "id" : 14467, "points" : [ { "x" : 352, "y" : 414 } ] } ], "outputs" : [ { "id" : 310, "points" : [ { "x" : 247, "y" : 562 } ] }, { "id" : 311, "points" : [ { "x" : 323, "y" : 523 } ] } ], "catalysts" : [ { "id" : 297, "points" : [ { "x" : 207, "y" : 353 }, { "x" : 170, "y" : 457 } ] } ] }, { "id" : 16181, "reactomeId" : 9851112, "displayName" : "NPM1-ALK- and TYK2-dependent MCL1 gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1196, "y" : 3011 }, "isDisease" : true, "minX" : 1143, "maxX" : 1350, "minY" : 3005, "maxY" : 3017, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1350, "y" : 3014 }, "to" : { "x" : 1196, "y" : 3011 } }, { "from" : { "x" : 1196, "y" : 3011 }, "to" : { "x" : 1143, "y" : 3011 } } ], "endShape" : { "a" : { "x" : 1150, "y" : 3007 }, "b" : { "x" : 1143, "y" : 3011 }, "c" : { "x" : 1150, "y" : 3015 }, "type" : "ARROW", "centre" : { "x" : 1150, "y" : 3015 } }, "reactionShape" : { "a" : { "x" : 1190, "y" : 3005 }, "b" : { "x" : 1202, "y" : 3017 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1196, "y" : 3011 } }, "inputs" : [ { "id" : 16182 } ], "outputs" : [ { "id" : 16183 } ], "activators" : [ { "id" : 16184, "points" : [ { "x" : 1137, "y" : 3202 } ] } ] }, { "id" : 15925, "reactomeId" : 9851137, "displayName" : "STAT3-dependent DNMT1 gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2524, "y" : 1692 }, "isDisease" : true, "minX" : 2298, "maxX" : 2746, "minY" : 1669, "maxY" : 1698, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2298, "y" : 1669 }, "to" : { "x" : 2524, "y" : 1692 } }, { "from" : { "x" : 2524, "y" : 1692 }, "to" : { "x" : 2746, "y" : 1697 } } ], "endShape" : { "a" : { "x" : 2739, "y" : 1701 }, "b" : { "x" : 2746, "y" : 1697 }, "c" : { "x" : 2739, "y" : 1693 }, "type" : "ARROW", "centre" : { "x" : 2739, "y" : 1693 } }, "reactionShape" : { "a" : { "x" : 2518, "y" : 1686 }, "b" : { "x" : 2530, "y" : 1698 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2524, "y" : 1692 } }, "inputs" : [ { "id" : 15926 } ], "outputs" : [ { "id" : 15910 } ], "activators" : [ { "id" : 15927, "points" : [ { "x" : 2528, "y" : 1744 } ] } ] }, { "id" : 15671, "reactomeId" : 9851109, "displayName" : "NPM1-ALK- and STAT3-dependent TWIST gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1724, "y" : 2237 }, "isDisease" : true, "minX" : 1671, "maxX" : 1771, "minY" : 2231, "maxY" : 2243, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1671, "y" : 2236 }, "to" : { "x" : 1724, "y" : 2237 } }, { "from" : { "x" : 1724, "y" : 2237 }, "to" : { "x" : 1771, "y" : 2237 } } ], "endShape" : { "a" : { "x" : 1764, "y" : 2241 }, "b" : { "x" : 1771, "y" : 2237 }, "c" : { "x" : 1764, "y" : 2233 }, "type" : "ARROW", "centre" : { "x" : 1764, "y" : 2233 } }, "reactionShape" : { "a" : { "x" : 1718, "y" : 2231 }, "b" : { "x" : 1730, "y" : 2243 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1724, "y" : 2237 } }, "inputs" : [ { "id" : 15672 } ], "outputs" : [ { "id" : 15673 } ], "activators" : [ { "id" : 13980, "points" : [ { "x" : 1636, "y" : 1511 }, { "x" : 1696, "y" : 1932 } ] } ] }, { "id" : 13881, "reactomeId" : 9701488, "displayName" : "Active ALK phosphorylates JAK3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 298, "y" : 1526 }, "isFadeOut" : true, "minX" : 292, "maxX" : 304, "minY" : 1499, "maxY" : 1555, "segments" : [ { "from" : { "x" : 300, "y" : 1499 }, "to" : { "x" : 298, "y" : 1526 } }, { "from" : { "x" : 298, "y" : 1526 }, "to" : { "x" : 298, "y" : 1555 } } ], "reactionShape" : { "a" : { "x" : 292, "y" : 1520 }, "b" : { "x" : 304, "y" : 1532 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 298, "y" : 1526 } }, "inputs" : [ { "id" : 13882, "points" : [ { "x" : 292, "y" : 1411 } ] }, { "id" : 13883, "points" : [ { "x" : 329, "y" : 1473 } ] } ], "outputs" : [ { "id" : 13884, "points" : [ { "x" : 323, "y" : 1560 } ] }, { "id" : 13885, "points" : [ { "x" : 300, "y" : 1605 } ] } ], "catalysts" : [ { "id" : 13882, "points" : [ { "x" : 285, "y" : 1411 }, { "x" : 248, "y" : 1485 } ] } ] }, { "id" : 15674, "reactomeId" : 9851106, "displayName" : "p-Y705, S727 STAT3 dimer binds ICOS promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2030, "y" : 2144 }, "isDisease" : true, "minX" : 1972, "maxX" : 2161, "minY" : 2139, "maxY" : 2233, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1972, "y" : 2233 }, "to" : { "x" : 2030, "y" : 2144 } }, { "from" : { "x" : 2030, "y" : 2144 }, "to" : { "x" : 2161, "y" : 2144 } } ], "endShape" : { "a" : { "x" : 2154, "y" : 2148 }, "b" : { "x" : 2161, "y" : 2144 }, "c" : { "x" : 2154, "y" : 2140 }, "type" : "ARROW", "centre" : { "x" : 2154, "y" : 2140 } }, "reactionShape" : { "c" : { "x" : 2030, "y" : 2144 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2030, "y" : 2144 } }, "inputs" : [ { "id" : 15631, "points" : [ { "x" : 2233, "y" : 2253 } ] }, { "id" : 13980, "points" : [ { "x" : 1642, "y" : 1511 } ] } ], "outputs" : [ { "id" : 15632 } ] }, { "id" : 13886, "reactomeId" : 9701485, "displayName" : "Active ALK binds JAK3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 440, "y" : 1310 }, "isFadeOut" : true, "minX" : 310, "maxX" : 512, "minY" : 1264, "maxY" : 1382, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 512, "y" : 1264 }, "to" : { "x" : 440, "y" : 1310 } }, { "from" : { "x" : 440, "y" : 1310 }, "to" : { "x" : 310, "y" : 1382 } } ], "endShape" : { "a" : { "x" : 314, "y" : 1375 }, "b" : { "x" : 310, "y" : 1382 }, "c" : { "x" : 318, "y" : 1382 }, "type" : "ARROW", "centre" : { "x" : 318, "y" : 1382 } }, "reactionShape" : { "c" : { "x" : 440, "y" : 1310 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 440, "y" : 1310 } }, "inputs" : [ { "id" : 13887, "points" : [ { "x" : 604, "y" : 1309 } ] }, { "id" : 15541, "points" : [ { "x" : 1215, "y" : 216 }, { "x" : 1112, "y" : 715 } ] } ], "outputs" : [ { "id" : 13882 } ] }, { "id" : 13891, "reactomeId" : 9701507, "displayName" : "PTPN6 dephosphorylates JAK3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 397, "y" : 1493 }, "isFadeOut" : true, "minX" : 391, "maxX" : 403, "minY" : 1451, "maxY" : 1577, "segments" : [ { "from" : { "x" : 391, "y" : 1577 }, "to" : { "x" : 397, "y" : 1493 } }, { "from" : { "x" : 397, "y" : 1493 }, "to" : { "x" : 395, "y" : 1451 } } ], "reactionShape" : { "a" : { "x" : 391, "y" : 1487 }, "b" : { "x" : 403, "y" : 1499 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 397, "y" : 1493 } }, "inputs" : [ { "id" : 13892, "points" : [ { "x" : 411, "y" : 1592 } ] }, { "id" : 13885, "points" : [ { "x" : 334, "y" : 1605 } ] } ], "outputs" : [ { "id" : 13882, "points" : [ { "x" : 312, "y" : 1411 } ] }, { "id" : 13896, "points" : [ { "x" : 431, "y" : 1435 } ] } ], "catalysts" : [ { "id" : 13894, "points" : [ { "x" : 435, "y" : 1493 } ] } ] }, { "id" : 16452, "reactomeId" : 9851079, "displayName" : "p-T,Y MAPK8,9 translocate to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1190, "y" : 2920 }, "isDisease" : true, "minX" : 1156, "maxX" : 1228, "minY" : 2914, "maxY" : 2926, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1156, "y" : 2919 }, "to" : { "x" : 1190, "y" : 2920 } }, { "from" : { "x" : 1190, "y" : 2920 }, "to" : { "x" : 1228, "y" : 2919 } } ], "endShape" : { "a" : { "x" : 1221, "y" : 2923 }, "b" : { "x" : 1228, "y" : 2919 }, "c" : { "x" : 1221, "y" : 2915 }, "type" : "ARROW", "centre" : { "x" : 1221, "y" : 2915 } }, "reactionShape" : { "a" : { "x" : 1184, "y" : 2914 }, "b" : { "x" : 1196, "y" : 2926 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1190, "y" : 2920 } }, "inputs" : [ { "id" : 16439 } ], "outputs" : [ { "id" : 16398 } ] }, { "id" : 13897, "reactomeId" : 9701524, "displayName" : "STAT3 is phosphorylated downstream of active ALK", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1070, "y" : 1126 }, "isFadeOut" : true, "minX" : 1064, "maxX" : 1105, "minY" : 996, "maxY" : 1165, "reactionType" : "Uncertain Process", "segments" : [ { "from" : { "x" : 1105, "y" : 996 }, "to" : { "x" : 1070, "y" : 1126 } }, { "from" : { "x" : 1070, "y" : 1126 }, "to" : { "x" : 1067, "y" : 1165 } } ], "endShape" : { "a" : { "x" : 1064, "y" : 1158 }, "b" : { "x" : 1067, "y" : 1165 }, "c" : { "x" : 1072, "y" : 1158 }, "type" : "ARROW", "centre" : { "x" : 1072, "y" : 1158 } }, "reactionShape" : { "a" : { "x" : 1064, "y" : 1120 }, "b" : { "x" : 1076, "y" : 1132 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 1070, "y" : 1126 } }, "inputs" : [ { "id" : 13898, "points" : [ { "x" : 946, "y" : 1033 } ] }, { "id" : 15541, "points" : [ { "x" : 1216, "y" : 216 } ] } ], "outputs" : [ { "id" : 13907 } ] }, { "id" : 15435, "reactomeId" : 9725345, "displayName" : "NPM1-ALK-dependent JUNB translation", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2640, "y" : 2691 }, "isDisease" : true, "minX" : 2501, "maxX" : 2771, "minY" : 2608, "maxY" : 2697, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2771, "y" : 2608 }, "to" : { "x" : 2640, "y" : 2691 } }, { "from" : { "x" : 2640, "y" : 2691 }, "to" : { "x" : 2501, "y" : 2696 } } ], "endShape" : { "a" : { "x" : 2508, "y" : 2692 }, "b" : { "x" : 2501, "y" : 2696 }, "c" : { "x" : 2508, "y" : 2700 }, "type" : "ARROW", "centre" : { "x" : 2508, "y" : 2700 } }, "reactionShape" : { "a" : { "x" : 2634, "y" : 2685 }, "b" : { "x" : 2646, "y" : 2697 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2640, "y" : 2691 } }, "inputs" : [ { "id" : 15434 } ], "outputs" : [ { "id" : 15410 } ], "activators" : [ { "id" : 15436, "points" : [ { "x" : 2794, "y" : 2687 } ] } ] }, { "id" : 14925, "reactomeId" : 9724099, "displayName" : "ALK mutants:p-3Y SHC binds GRB2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2001, "y" : 955 }, "isDisease" : true, "minX" : 1979, "maxX" : 2028, "minY" : 950, "maxY" : 960, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1979, "y" : 956 }, "to" : { "x" : 2001, "y" : 955 } }, { "from" : { "x" : 2001, "y" : 955 }, "to" : { "x" : 2028, "y" : 954 } } ], "endShape" : { "a" : { "x" : 2021, "y" : 958 }, "b" : { "x" : 2028, "y" : 954 }, "c" : { "x" : 2021, "y" : 950 }, "type" : "ARROW", "centre" : { "x" : 2021, "y" : 950 } }, "reactionShape" : { "c" : { "x" : 2001, "y" : 955 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2001, "y" : 955 } }, "inputs" : [ { "id" : 14232, "points" : [ { "x" : 1720, "y" : 951 } ] }, { "id" : 13591, "points" : [ { "x" : 1991, "y" : 642 } ] } ], "outputs" : [ { "id" : 14926 } ] }, { "id" : 336, "reactomeId" : 9700149, "displayName" : "Active ALK binds PLCG1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 240, "y" : 669 }, "isFadeOut" : true, "minX" : 235, "maxX" : 246, "minY" : 633, "maxY" : 711, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 246, "y" : 633 }, "to" : { "x" : 240, "y" : 669 } }, { "from" : { "x" : 240, "y" : 669 }, "to" : { "x" : 237, "y" : 711 } } ], "endShape" : { "a" : { "x" : 234, "y" : 704 }, "b" : { "x" : 237, "y" : 711 }, "c" : { "x" : 241, "y" : 704 }, "type" : "ARROW", "centre" : { "x" : 241, "y" : 704 } }, "reactionShape" : { "c" : { "x" : 240, "y" : 669 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 240, "y" : 669 } }, "inputs" : [ { "id" : 337, "points" : [ { "x" : 287, "y" : 641 } ] }, { "id" : 310, "points" : [ { "x" : 246, "y" : 599 } ] }, { "id" : 15541, "points" : [ { "x" : 1192, "y" : 216 } ] } ], "outputs" : [ { "id" : 338 } ] }, { "id" : 339, "reactomeId" : 9700171, "displayName" : "Active ALK phosphorylates PLCG1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 252, "y" : 968 }, "isFadeOut" : true, "minX" : 246, "maxX" : 258, "minY" : 903, "maxY" : 1015, "segments" : [ { "from" : { "x" : 253, "y" : 903 }, "to" : { "x" : 252, "y" : 968 } }, { "from" : { "x" : 252, "y" : 968 }, "to" : { "x" : 255, "y" : 1015 } } ], "reactionShape" : { "a" : { "x" : 246, "y" : 962 }, "b" : { "x" : 258, "y" : 974 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 252, "y" : 968 } }, "inputs" : [ { "id" : 340, "points" : [ { "x" : 312, "y" : 857 } ], "stoichiometry" : 4 }, { "id" : 338, "points" : [ { "x" : 238, "y" : 740 } ] } ], "outputs" : [ { "id" : 348, "points" : [ { "x" : 345, "y" : 1018 } ], "stoichiometry" : 4 }, { "id" : 341, "points" : [ { "x" : 256, "y" : 1107 } ] } ], "catalysts" : [ { "id" : 338, "points" : [ { "x" : 233, "y" : 740 }, { "x" : 202, "y" : 838 } ] } ] }, { "id" : 16212, "reactomeId" : 9851114, "displayName" : "NPM1-ALK-dependent TYK2 phosphorylation", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1013, "y" : 3264 }, "isDisease" : true, "minX" : 983, "maxX" : 1052, "minY" : 3258, "maxY" : 3270, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 983, "y" : 3265 }, "to" : { "x" : 1013, "y" : 3264 } }, { "from" : { "x" : 1013, "y" : 3264 }, "to" : { "x" : 1052, "y" : 3262 } } ], "reactionShape" : { "a" : { "x" : 1007, "y" : 3258 }, "b" : { "x" : 1019, "y" : 3270 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1013, "y" : 3264 } }, "inputs" : [ { "id" : 16213, "points" : [ { "x" : 934, "y" : 3236 } ] }, { "id" : 16214, "points" : [ { "x" : 931, "y" : 3289 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 16184, "points" : [ { "x" : 1094, "y" : 3245 } ] }, { "id" : 16215, "points" : [ { "x" : 1074, "y" : 3296 } ], "stoichiometry" : 2 } ], "activators" : [ { "id" : 16216, "points" : [ { "x" : 1067, "y" : 3454 } ] }, { "id" : 16217, "points" : [ { "x" : 948, "y" : 3456 } ] }, { "id" : 15275, "points" : [ { "x" : 1058, "y" : 2563 }, { "x" : 947, "y" : 2756 } ] } ] }, { "id" : 14426, "reactomeId" : 9712086, "displayName" : "ALK fusions phosphorylate PLCG1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 292, "y" : 944 }, "isDisease" : true, "minX" : 286, "maxX" : 301, "minY" : 898, "maxY" : 980, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 291, "y" : 898 }, "to" : { "x" : 292, "y" : 944 } }, { "from" : { "x" : 292, "y" : 944 }, "to" : { "x" : 301, "y" : 980 } } ], "reactionShape" : { "a" : { "x" : 286, "y" : 938 }, "b" : { "x" : 298, "y" : 950 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 292, "y" : 944 } }, "inputs" : [ { "id" : 14236, "points" : [ { "x" : 313, "y" : 816 } ] }, { "id" : 340, "points" : [ { "x" : 322, "y" : 862 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 14429, "points" : [ { "x" : 336, "y" : 1044 } ] }, { "id" : 348, "points" : [ { "x" : 345, "y" : 1007 } ], "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 14236, "points" : [ { "x" : 350, "y" : 816 }, { "x" : 433, "y" : 881 } ] } ] }, { "id" : 355, "reactomeId" : 9700648, "displayName" : "Active ALK binds SRC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1422, "y" : 578 }, "isFadeOut" : true, "minX" : 1329, "maxX" : 2076, "minY" : 536, "maxY" : 583, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1329, "y" : 536 }, "to" : { "x" : 1422, "y" : 578 } }, { "from" : { "x" : 1422, "y" : 578 }, "to" : { "x" : 2076, "y" : 568 } } ], "endShape" : { "a" : { "x" : 2069, "y" : 572 }, "b" : { "x" : 2076, "y" : 568 }, "c" : { "x" : 2069, "y" : 564 }, "type" : "ARROW", "centre" : { "x" : 2069, "y" : 564 } }, "reactionShape" : { "c" : { "x" : 1422, "y" : 578 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1422, "y" : 578 } }, "inputs" : [ { "id" : 356, "points" : [ { "x" : 1313, "y" : 533 } ] }, { "id" : 15541, "points" : [ { "x" : 1221, "y" : 216 } ] } ], "outputs" : [ { "id" : 357 } ] }, { "id" : 15460, "reactomeId" : 9725338, "displayName" : "NPM1-ALK-dependent BCL2A1 gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1579, "y" : 3003 }, "isDisease" : true, "minX" : 1499, "maxX" : 1585, "minY" : 2997, "maxY" : 3132, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1499, "y" : 3022 }, "to" : { "x" : 1579, "y" : 3003 } }, { "from" : { "x" : 1579, "y" : 3003 }, "to" : { "x" : 1576, "y" : 3132 } } ], "endShape" : { "a" : { "x" : 1572, "y" : 3125 }, "b" : { "x" : 1576, "y" : 3132 }, "c" : { "x" : 1580, "y" : 3125 }, "type" : "ARROW", "centre" : { "x" : 1580, "y" : 3125 } }, "reactionShape" : { "a" : { "x" : 1573, "y" : 2997 }, "b" : { "x" : 1585, "y" : 3009 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1579, "y" : 3003 } }, "inputs" : [ { "id" : 15461 } ], "outputs" : [ { "id" : 15462 } ], "activators" : [ { "id" : 15260, "points" : [ { "x" : 1366, "y" : 2560 }, { "x" : 1568, "y" : 2850 } ] } ] }, { "id" : 358, "reactomeId" : 9700647, "displayName" : "Active ALK phosphorylates SRC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2142, "y" : 650 }, "isFadeOut" : true, "minX" : 2136, "maxX" : 2148, "minY" : 623, "maxY" : 680, "segments" : [ { "from" : { "x" : 2140, "y" : 623 }, "to" : { "x" : 2142, "y" : 650 } }, { "from" : { "x" : 2142, "y" : 650 }, "to" : { "x" : 2143, "y" : 680 } } ], "reactionShape" : { "a" : { "x" : 2136, "y" : 644 }, "b" : { "x" : 2148, "y" : 656 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2142, "y" : 650 } }, "inputs" : [ { "id" : 359, "points" : [ { "x" : 2165, "y" : 613 } ] }, { "id" : 357, "points" : [ { "x" : 2128, "y" : 583 } ] } ], "outputs" : [ { "id" : 360, "points" : [ { "x" : 2147, "y" : 759 } ] }, { "id" : 361, "points" : [ { "x" : 2171, "y" : 689 } ] } ], "catalysts" : [ { "id" : 357, "points" : [ { "x" : 2112, "y" : 583 }, { "x" : 2077, "y" : 611 } ] } ] }, { "id" : 103, "reactomeId" : 201521, "displayName" : "ALK autophosphorylation", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 887, "y" : 209 }, "isFadeOut" : true, "minX" : 816, "maxX" : 917, "minY" : 203, "maxY" : 215, "segments" : [ { "from" : { "x" : 816, "y" : 210 }, "to" : { "x" : 887, "y" : 209 } }, { "from" : { "x" : 887, "y" : 209 }, "to" : { "x" : 917, "y" : 209 } } ], "reactionShape" : { "a" : { "x" : 881, "y" : 203 }, "b" : { "x" : 893, "y" : 215 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 887, "y" : 209 } }, "inputs" : [ { "id" : 15519, "points" : [ { "x" : 797, "y" : 239 } ], "stoichiometry" : 6 }, { "id" : 15520, "points" : [ { "x" : 783, "y" : 209 } ] } ], "outputs" : [ { "id" : 15541, "points" : [ { "x" : 1159, "y" : 199 } ] }, { "id" : 15544, "points" : [ { "x" : 939, "y" : 231 } ], "stoichiometry" : 6 } ], "catalysts" : [ { "id" : 15520, "points" : [ { "x" : 774, "y" : 184 }, { "x" : 821, "y" : 174 } ] } ], "inhibitors" : [ { "id" : 413, "points" : [ { "x" : 895, "y" : 177 } ] } ] }, { "id" : 106, "reactomeId" : 9700200, "displayName" : "PTPRZ dephosphorylates ligand-bound ALK dimers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 305, "y" : 2358 }, "isFadeOut" : true, "minX" : 299, "maxX" : 311, "minY" : 2318, "maxY" : 2376, "segments" : [ { "from" : { "x" : 309, "y" : 2376 }, "to" : { "x" : 305, "y" : 2358 } }, { "from" : { "x" : 305, "y" : 2358 }, "to" : { "x" : 306, "y" : 2318 } } ], "reactionShape" : { "a" : { "x" : 299, "y" : 2352 }, "b" : { "x" : 311, "y" : 2364 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 305, "y" : 2358 } }, "inputs" : [ { "id" : 96, "points" : [ { "x" : 320, "y" : 2440 } ] }, { "id" : 107, "points" : [ { "x" : 400, "y" : 2402 } ], "stoichiometry" : 6 } ], "outputs" : [ { "id" : 92, "points" : [ { "x" : 315, "y" : 2240 } ] }, { "id" : 108, "points" : [ { "x" : 357, "y" : 2272 } ], "stoichiometry" : 6 } ], "catalysts" : [ { "id" : 109, "points" : [ { "x" : 217, "y" : 2234 } ] } ], "inhibitors" : [ { "id" : 116, "points" : [ { "x" : 234, "y" : 2410 } ] } ] }, { "id" : 15723, "reactomeId" : 9851118, "displayName" : "pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2224, "y" : 1994 }, "isDisease" : true, "minX" : 2143, "maxX" : 2297, "minY" : 1989, "maxY" : 2011, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2143, "y" : 2011 }, "to" : { "x" : 2224, "y" : 1994 } }, { "from" : { "x" : 2224, "y" : 1994 }, "to" : { "x" : 2297, "y" : 1997 } } ], "endShape" : { "a" : { "x" : 2290, "y" : 2001 }, "b" : { "x" : 2297, "y" : 1997 }, "c" : { "x" : 2290, "y" : 1993 }, "type" : "ARROW", "centre" : { "x" : 2290, "y" : 1993 } }, "reactionShape" : { "c" : { "x" : 2224, "y" : 1994 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2224, "y" : 1994 } }, "inputs" : [ { "id" : 15724, "points" : [ { "x" : 2157, "y" : 2043 } ] }, { "id" : 13980, "points" : [ { "x" : 1644, "y" : 1511 }, { "x" : 1963, "y" : 2063 } ] } ], "outputs" : [ { "id" : 15726 } ] }, { "id" : 15727, "reactomeId" : 9851117, "displayName" : "NPM1-ALK- and p-STAT3-dependent IRF4 gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2371, "y" : 2065 }, "isDisease" : true, "minX" : 2157, "maxX" : 2781, "minY" : 2043, "maxY" : 2083, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2157, "y" : 2043 }, "to" : { "x" : 2371, "y" : 2065 } }, { "from" : { "x" : 2371, "y" : 2065 }, "to" : { "x" : 2781, "y" : 2083 } } ], "endShape" : { "a" : { "x" : 2774, "y" : 2087 }, "b" : { "x" : 2781, "y" : 2083 }, "c" : { "x" : 2774, "y" : 2079 }, "type" : "ARROW", "centre" : { "x" : 2774, "y" : 2079 } }, "reactionShape" : { "a" : { "x" : 2365, "y" : 2059 }, "b" : { "x" : 2377, "y" : 2071 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2371, "y" : 2065 } }, "inputs" : [ { "id" : 15724 } ], "outputs" : [ { "id" : 15728 } ], "activators" : [ { "id" : 15726, "points" : [ { "x" : 2368, "y" : 2022 } ] } ] }, { "id" : 15472, "reactomeId" : 9725357, "displayName" : "NPM1-ALK-dependent CEBPB gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2040, "y" : 2443 }, "isDisease" : true, "minX" : 1947, "maxX" : 2143, "minY" : 2434, "maxY" : 2449, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1947, "y" : 2434 }, "to" : { "x" : 2040, "y" : 2443 } }, { "from" : { "x" : 2040, "y" : 2443 }, "to" : { "x" : 2143, "y" : 2435 } } ], "endShape" : { "a" : { "x" : 2136, "y" : 2440 }, "b" : { "x" : 2143, "y" : 2435 }, "c" : { "x" : 2136, "y" : 2432 }, "type" : "ARROW", "centre" : { "x" : 2136, "y" : 2432 } }, "reactionShape" : { "a" : { "x" : 2034, "y" : 2437 }, "b" : { "x" : 2046, "y" : 2449 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2040, "y" : 2443 } }, "inputs" : [ { "id" : 15473 } ], "outputs" : [ { "id" : 15474 } ], "activators" : [ { "id" : 13980, "points" : [ { "x" : 1639, "y" : 1511 }, { "x" : 1810, "y" : 2104 } ] }, { "id" : 15260, "points" : [ { "x" : 1418, "y" : 2532 }, { "x" : 1910, "y" : 2545 } ] }, { "id" : 15413, "points" : [ { "x" : 2036, "y" : 2532 } ] } ] }, { "id" : 115, "reactomeId" : 9700121, "displayName" : "(PTN,MDK):PTPRZ oligomerizes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 193, "y" : 2379 }, "isFadeOut" : true, "minX" : 188, "maxX" : 203, "minY" : 2339, "maxY" : 2410, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 201, "y" : 2339 }, "to" : { "x" : 193, "y" : 2379 } }, { "from" : { "x" : 193, "y" : 2379 }, "to" : { "x" : 203, "y" : 2410 } } ], "endShape" : { "a" : { "x" : 197, "y" : 2405 }, "b" : { "x" : 203, "y" : 2410 }, "c" : { "x" : 205, "y" : 2402 }, "type" : "ARROW", "centre" : { "x" : 205, "y" : 2402 } }, "reactionShape" : { "c" : { "x" : 193, "y" : 2379 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 193, "y" : 2379 } }, "inputs" : [ { "id" : 114, "stoichiometry" : 6 } ], "outputs" : [ { "id" : 116 } ] }, { "id" : 14708, "reactomeId" : 9712088, "displayName" : "ALK fusion proteins bind IRS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1581, "y" : 431 }, "isDisease" : true, "minX" : 1484, "maxX" : 1621, "minY" : 426, "maxY" : 436, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1484, "y" : 432 }, "to" : { "x" : 1581, "y" : 431 } }, { "from" : { "x" : 1581, "y" : 431 }, "to" : { "x" : 1621, "y" : 429 } } ], "endShape" : { "a" : { "x" : 1614, "y" : 433 }, "b" : { "x" : 1621, "y" : 429 }, "c" : { "x" : 1614, "y" : 425 }, "type" : "ARROW", "centre" : { "x" : 1614, "y" : 425 } }, "reactionShape" : { "c" : { "x" : 1581, "y" : 431 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1581, "y" : 431 } }, "inputs" : [ { "id" : 175, "points" : [ { "x" : 1418, "y" : 354 } ] }, { "id" : 15475, "points" : [ { "x" : 1455, "y" : 492 } ] } ], "outputs" : [ { "id" : 14709 } ] }, { "id" : 15989, "reactomeId" : 9851071, "displayName" : "STAT3, DNMT1 and HDAC1 bind PTPN6 gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1440, "y" : 1912 }, "isDisease" : true, "minX" : 1372, "maxX" : 1556, "minY" : 1907, "maxY" : 1917, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1556, "y" : 1907 }, "to" : { "x" : 1440, "y" : 1912 } }, { "from" : { "x" : 1440, "y" : 1912 }, "to" : { "x" : 1372, "y" : 1907 } } ], "endShape" : { "a" : { "x" : 1379, "y" : 1904 }, "b" : { "x" : 1372, "y" : 1907 }, "c" : { "x" : 1379, "y" : 1911 }, "type" : "ARROW", "centre" : { "x" : 1379, "y" : 1911 } }, "reactionShape" : { "c" : { "x" : 1440, "y" : 1912 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1440, "y" : 1912 } }, "inputs" : [ { "id" : 13980, "points" : [ { "x" : 1630, "y" : 1511 } ] }, { "id" : 15991, "points" : [ { "x" : 1452, "y" : 1870 } ] }, { "id" : 15844, "points" : [ { "x" : 2185, "y" : 1654 } ] }, { "id" : 16907, "points" : [ { "x" : 1503, "y" : 2000 } ] } ], "outputs" : [ { "id" : 15992 } ] }, { "id" : 14710, "reactomeId" : 9712082, "displayName" : "ALK fusions phosphorylate IRS1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1797, "y" : 420 }, "isDisease" : true, "minX" : 1770, "maxX" : 1828, "minY" : 414, "maxY" : 426, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1770, "y" : 422 }, "to" : { "x" : 1797, "y" : 420 } }, { "from" : { "x" : 1797, "y" : 420 }, "to" : { "x" : 1828, "y" : 420 } } ], "reactionShape" : { "a" : { "x" : 1791, "y" : 414 }, "b" : { "x" : 1803, "y" : 426 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1797, "y" : 420 } }, "inputs" : [ { "id" : 14711, "points" : [ { "x" : 1762, "y" : 447 } ] }, { "id" : 14709, "points" : [ { "x" : 1721, "y" : 425 } ] } ], "outputs" : [ { "id" : 14712, "points" : [ { "x" : 1850, "y" : 436 } ] }, { "id" : 14713, "points" : [ { "x" : 1901, "y" : 421 } ] } ], "catalysts" : [ { "id" : 14709, "points" : [ { "x" : 1712, "y" : 407 }, { "x" : 1790, "y" : 375 } ] } ] }, { "id" : 15480, "reactomeId" : 9700662, "displayName" : "Liganded-ALK dimer binds type I ALK-binding TKIs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 745, "y" : 156 }, "isFadeOut" : true, "minX" : 613, "maxX" : 839, "minY" : 151, "maxY" : 161, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 613, "y" : 155 }, "to" : { "x" : 745, "y" : 156 } }, { "from" : { "x" : 745, "y" : 156 }, "to" : { "x" : 839, "y" : 151 } } ], "endShape" : { "a" : { "x" : 832, "y" : 155 }, "b" : { "x" : 839, "y" : 151 }, "c" : { "x" : 832, "y" : 147 }, "type" : "ARROW", "centre" : { "x" : 832, "y" : 147 } }, "reactionShape" : { "c" : { "x" : 745, "y" : 156 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 745, "y" : 156 } }, "inputs" : [ { "id" : 15520, "points" : [ { "x" : 681, "y" : 184 } ] }, { "id" : 416, "points" : [ { "x" : 540, "y" : 268 } ] } ], "outputs" : [ { "id" : 413 } ] }, { "id" : 15737, "reactomeId" : 9851090, "displayName" : "NPM1-ALK binds NPM1 and FOXM1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1346, "y" : 2609 }, "isDisease" : true, "minX" : 1341, "maxX" : 1351, "minY" : 2590, "maxY" : 2639, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1347, "y" : 2590 }, "to" : { "x" : 1346, "y" : 2609 } }, { "from" : { "x" : 1346, "y" : 2609 }, "to" : { "x" : 1349, "y" : 2639 } } ], "endShape" : { "a" : { "x" : 1344, "y" : 2633 }, "b" : { "x" : 1349, "y" : 2639 }, "c" : { "x" : 1352, "y" : 2632 }, "type" : "ARROW", "centre" : { "x" : 1352, "y" : 2632 } }, "reactionShape" : { "c" : { "x" : 1346, "y" : 2609 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1346, "y" : 2609 } }, "inputs" : [ { "id" : 15738, "points" : [ { "x" : 1302, "y" : 2606 } ] }, { "id" : 15260, "points" : [ { "x" : 1348, "y" : 2560 } ] }, { "id" : 15740, "points" : [ { "x" : 1301, "y" : 2578 } ] } ], "outputs" : [ { "id" : 15741 } ] }, { "id" : 15997, "reactomeId" : 9851072, "displayName" : "DNMT1-dependent PTPN6 gene silencing", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 780, "y" : 2026 }, "isDisease" : true, "minX" : 468, "maxX" : 1503, "minY" : 1509, "maxY" : 2032, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1503, "y" : 2000 }, "to" : { "x" : 780, "y" : 2026 } }, { "from" : { "x" : 780, "y" : 2026 }, "to" : { "x" : 468, "y" : 1509 } } ], "endShape" : { "a" : { "x" : 475, "y" : 1513 }, "b" : { "x" : 468, "y" : 1509 }, "c" : { "x" : 468, "y" : 1517 }, "type" : "ARROW", "centre" : { "x" : 468, "y" : 1517 } }, "reactionShape" : { "a" : { "x" : 774, "y" : 2020 }, "b" : { "x" : 786, "y" : 2032 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 780, "y" : 2026 } }, "inputs" : [ { "id" : 16907 } ], "outputs" : [ { "id" : 13894 } ], "inhibitors" : [ { "id" : 15992, "points" : [ { "x" : 1240, "y" : 1918 } ] } ] }, { "id" : 15998, "reactomeId" : 9701557, "displayName" : "AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2307, "y" : 1434 }, "isFadeOut" : true, "minX" : 2267, "maxX" : 2468, "minY" : 1429, "maxY" : 1439, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 2267, "y" : 1436 }, "to" : { "x" : 2307, "y" : 1434 } }, { "from" : { "x" : 2307, "y" : 1434 }, "to" : { "x" : 2468, "y" : 1434 } } ], "endShape" : { "a" : { "x" : 2461, "y" : 1438 }, "b" : { "x" : 2468, "y" : 1434 }, "c" : { "x" : 2461, "y" : 1430 }, "type" : "ARROW", "centre" : { "x" : 2461, "y" : 1430 } }, "reactionShape" : { "c" : { "x" : 2307, "y" : 1434 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2307, "y" : 1434 } }, "inputs" : [ { "id" : 14069, "points" : [ { "x" : 2191, "y" : 1474 } ] }, { "id" : 14015, "points" : [ { "x" : 2020, "y" : 1470 } ] }, { "id" : 14016, "points" : [ { "x" : 2086, "y" : 1427 } ] } ], "outputs" : [ { "id" : 14070 } ] }, { "id" : 15746, "reactomeId" : 9851092, "displayName" : "NPM1-ALK and FOXM1-dependent CCNB1 gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1352, "y" : 2718 }, "isDisease" : true, "minX" : 1315, "maxX" : 1405, "minY" : 2712, "maxY" : 2724, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1315, "y" : 2722 }, "to" : { "x" : 1352, "y" : 2718 } }, { "from" : { "x" : 1352, "y" : 2718 }, "to" : { "x" : 1405, "y" : 2720 } } ], "endShape" : { "a" : { "x" : 1398, "y" : 2724 }, "b" : { "x" : 1405, "y" : 2720 }, "c" : { "x" : 1398, "y" : 2716 }, "type" : "ARROW", "centre" : { "x" : 1398, "y" : 2716 } }, "reactionShape" : { "a" : { "x" : 1346, "y" : 2712 }, "b" : { "x" : 1358, "y" : 2724 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1352, "y" : 2718 } }, "inputs" : [ { "id" : 15747 } ], "outputs" : [ { "id" : 15748 } ], "activators" : [ { "id" : 15741, "points" : [ { "x" : 1351, "y" : 2682 } ] } ] }, { "id" : 16003, "reactomeId" : 9851058, "displayName" : "AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2300, "y" : 1575 }, "isFadeOut" : true, "minX" : 2238, "maxX" : 2474, "minY" : 1570, "maxY" : 1580, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 2238, "y" : 1578 }, "to" : { "x" : 2300, "y" : 1575 } }, { "from" : { "x" : 2300, "y" : 1575 }, "to" : { "x" : 2474, "y" : 1577 } } ], "endShape" : { "a" : { "x" : 2467, "y" : 1581 }, "b" : { "x" : 2474, "y" : 1577 }, "c" : { "x" : 2467, "y" : 1573 }, "type" : "ARROW", "centre" : { "x" : 2467, "y" : 1573 } }, "reactionShape" : { "c" : { "x" : 2300, "y" : 1575 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2300, "y" : 1575 } }, "inputs" : [ { "id" : 14069, "points" : [ { "x" : 2191, "y" : 1474 } ] }, { "id" : 14015, "points" : [ { "x" : 2008, "y" : 1501 } ] }, { "id" : 15844, "points" : [ { "x" : 2218, "y" : 1630 } ] } ], "outputs" : [ { "id" : 15838 } ] }, { "id" : 16020, "reactomeId" : 9851064, "displayName" : "AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2410, "y" : 1790 }, "isDisease" : true, "minX" : 2248, "maxX" : 2464, "minY" : 1781, "maxY" : 1826, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2248, "y" : 1826 }, "to" : { "x" : 2410, "y" : 1790 } }, { "from" : { "x" : 2410, "y" : 1790 }, "to" : { "x" : 2464, "y" : 1781 } } ], "endShape" : { "a" : { "x" : 2458, "y" : 1786 }, "b" : { "x" : 2464, "y" : 1781 }, "c" : { "x" : 2457, "y" : 1778 }, "type" : "ARROW", "centre" : { "x" : 2457, "y" : 1778 } }, "reactionShape" : { "c" : { "x" : 2410, "y" : 1790 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2410, "y" : 1790 } }, "inputs" : [ { "id" : 14015, "points" : [ { "x" : 1971, "y" : 1501 } ] }, { "id" : 15926, "points" : [ { "x" : 2298, "y" : 1669 } ] } ], "outputs" : [ { "id" : 15927 } ] }, { "id" : 14229, "reactomeId" : 9710914, "displayName" : "ALK fusions bind GRB2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1801, "y" : 926 }, "isDisease" : true, "minX" : 1773, "maxX" : 1828, "minY" : 921, "maxY" : 931, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1773, "y" : 926 }, "to" : { "x" : 1801, "y" : 926 } }, { "from" : { "x" : 1801, "y" : 926 }, "to" : { "x" : 1828, "y" : 924 } } ], "endShape" : { "a" : { "x" : 1821, "y" : 929 }, "b" : { "x" : 1828, "y" : 924 }, "c" : { "x" : 1821, "y" : 921 }, "type" : "ARROW", "centre" : { "x" : 1821, "y" : 921 } }, "reactionShape" : { "c" : { "x" : 1801, "y" : 926 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1801, "y" : 926 } }, "inputs" : [ { "id" : 14230, "points" : [ { "x" : 1760, "y" : 921 } ] }, { "id" : 14232, "points" : [ { "x" : 1720, "y" : 944 } ] } ], "outputs" : [ { "id" : 14233 } ] }, { "id" : 13977, "reactomeId" : 9701525, "displayName" : "p-Y705,S727-STAT3 dimerizes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1064, "y" : 1310 }, "isFadeOut" : true, "minX" : 1059, "maxX" : 1069, "minY" : 1208, "maxY" : 1490, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1065, "y" : 1208 }, "to" : { "x" : 1064, "y" : 1310 } }, { "from" : { "x" : 1064, "y" : 1310 }, "to" : { "x" : 1069, "y" : 1490 } } ], "endShape" : { "a" : { "x" : 1065, "y" : 1483 }, "b" : { "x" : 1069, "y" : 1490 }, "c" : { "x" : 1073, "y" : 1483 }, "type" : "ARROW", "centre" : { "x" : 1073, "y" : 1483 } }, "reactionShape" : { "c" : { "x" : 1064, "y" : 1310 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1064, "y" : 1310 } }, "inputs" : [ { "id" : 13907, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 13978 } ] }, { "id" : 15513, "reactomeId" : 9842656, "displayName" : "ALK binds ALKAL ligand", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 324, "y" : 148 }, "isFadeOut" : true, "minX" : 245, "maxX" : 420, "minY" : 122, "maxY" : 159, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 245, "y" : 122 }, "to" : { "x" : 324, "y" : 148 } }, { "from" : { "x" : 324, "y" : 148 }, "to" : { "x" : 420, "y" : 159 } } ], "endShape" : { "a" : { "x" : 413, "y" : 162 }, "b" : { "x" : 420, "y" : 159 }, "c" : { "x" : 414, "y" : 154 }, "type" : "ARROW", "centre" : { "x" : 414, "y" : 154 } }, "reactionShape" : { "c" : { "x" : 324, "y" : 148 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 324, "y" : 148 } }, "inputs" : [ { "id" : 15511, "points" : [ { "x" : 210, "y" : 35 } ] }, { "id" : 9, "points" : [ { "x" : 167, "y" : 95 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 15512 } ] }, { "id" : 15258, "reactomeId" : 9725023, "displayName" : "NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1444, "y" : 2461 }, "isDisease" : true, "minX" : 1425, "maxX" : 1464, "minY" : 2456, "maxY" : 2466, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1425, "y" : 2461 }, "to" : { "x" : 1444, "y" : 2461 } }, { "from" : { "x" : 1444, "y" : 2461 }, "to" : { "x" : 1464, "y" : 2459 } } ], "endShape" : { "a" : { "x" : 1458, "y" : 2464 }, "b" : { "x" : 1464, "y" : 2459 }, "c" : { "x" : 1457, "y" : 2456 }, "type" : "ARROW", "centre" : { "x" : 1457, "y" : 2456 } }, "reactionShape" : { "c" : { "x" : 1444, "y" : 2461 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1444, "y" : 2461 } }, "inputs" : [ { "id" : 15259, "points" : [ { "x" : 1413, "y" : 2439 } ] }, { "id" : 15260, "points" : [ { "x" : 1376, "y" : 2503 } ] } ], "outputs" : [ { "id" : 15261 } ] }, { "id" : 14234, "reactomeId" : 9710917, "displayName" : "ALK fusion proteins bind PLCG1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 422, "y" : 701 }, "isDisease" : true, "minX" : 350, "maxX" : 456, "minY" : 665, "maxY" : 759, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 456, "y" : 665 }, "to" : { "x" : 422, "y" : 701 } }, { "from" : { "x" : 422, "y" : 701 }, "to" : { "x" : 350, "y" : 759 } } ], "endShape" : { "a" : { "x" : 353, "y" : 752 }, "b" : { "x" : 350, "y" : 759 }, "c" : { "x" : 358, "y" : 758 }, "type" : "ARROW", "centre" : { "x" : 358, "y" : 758 } }, "reactionShape" : { "c" : { "x" : 422, "y" : 701 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 422, "y" : 701 } }, "inputs" : [ { "id" : 14230, "points" : [ { "x" : 1654, "y" : 867 }, { "x" : 1446, "y" : 822 } ] }, { "id" : 310, "points" : [ { "x" : 285, "y" : 599 } ] }, { "id" : 337, "points" : [ { "x" : 340, "y" : 649 } ] } ], "outputs" : [ { "id" : 14236 } ] }, { "id" : 13979, "reactomeId" : 9701529, "displayName" : "p-Y705, p-S727 STAT3 dimer translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1393, "y" : 1506 }, "isFadeOut" : true, "minX" : 1121, "maxX" : 1583, "minY" : 1492, "maxY" : 1512, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 1121, "y" : 1510 }, "to" : { "x" : 1393, "y" : 1506 } }, { "from" : { "x" : 1393, "y" : 1506 }, "to" : { "x" : 1583, "y" : 1492 } } ], "endShape" : { "a" : { "x" : 1576, "y" : 1496 }, "b" : { "x" : 1583, "y" : 1492 }, "c" : { "x" : 1576, "y" : 1489 }, "type" : "ARROW", "centre" : { "x" : 1576, "y" : 1489 } }, "reactionShape" : { "a" : { "x" : 1387, "y" : 1500 }, "b" : { "x" : 1399, "y" : 1512 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1393, "y" : 1506 } }, "inputs" : [ { "id" : 13978 } ], "outputs" : [ { "id" : 13980 } ] }, { "id" : 15773, "reactomeId" : 9725315, "displayName" : "ALK-stimulated MYCN gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1310, "y" : 1205 }, "isFadeOut" : true, "minX" : 1297, "maxX" : 1334, "minY" : 1199, "maxY" : 1211, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 1297, "y" : 1203 }, "to" : { "x" : 1310, "y" : 1205 } }, { "from" : { "x" : 1310, "y" : 1205 }, "to" : { "x" : 1334, "y" : 1204 } } ], "endShape" : { "a" : { "x" : 1327, "y" : 1208 }, "b" : { "x" : 1334, "y" : 1204 }, "c" : { "x" : 1327, "y" : 1200 }, "type" : "ARROW", "centre" : { "x" : 1327, "y" : 1200 } }, "reactionShape" : { "a" : { "x" : 1304, "y" : 1199 }, "b" : { "x" : 1316, "y" : 1211 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1310, "y" : 1205 } }, "inputs" : [ { "id" : 15550 } ], "outputs" : [ { "id" : 15551 } ], "activators" : [ { "id" : 15541, "points" : [ { "x" : 1219, "y" : 216 } ] } ] }, { "id" : 15262, "reactomeId" : 9725030, "displayName" : "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1652, "y" : 2458 }, "isDisease" : true, "minX" : 1628, "maxX" : 1671, "minY" : 2452, "maxY" : 2464, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1628, "y" : 2457 }, "to" : { "x" : 1652, "y" : 2458 } }, { "from" : { "x" : 1652, "y" : 2458 }, "to" : { "x" : 1671, "y" : 2458 } } ], "reactionShape" : { "a" : { "x" : 1646, "y" : 2452 }, "b" : { "x" : 1658, "y" : 2464 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1652, "y" : 2458 } }, "inputs" : [ { "id" : 15261, "points" : [ { "x" : 1595, "y" : 2457 } ] }, { "id" : 15263, "points" : [ { "x" : 1613, "y" : 2429 } ] } ], "outputs" : [ { "id" : 15264, "points" : [ { "x" : 1700, "y" : 2457 } ] }, { "id" : 15265, "points" : [ { "x" : 1692, "y" : 2415 } ] } ], "catalysts" : [ { "id" : 15266, "points" : [ { "x" : 1655, "y" : 2371 } ] } ] }, { "id" : 15782, "reactomeId" : 9851068, "displayName" : "Crizotinib-driven IL10RA gene expression in NPM1-ALK", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1737, "y" : 3082 }, "isDisease" : true, "minX" : 1724, "maxX" : 1743, "minY" : 3005, "maxY" : 3356, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1724, "y" : 3005 }, "to" : { "x" : 1737, "y" : 3082 } }, { "from" : { "x" : 1737, "y" : 3082 }, "to" : { "x" : 1740, "y" : 3356 } } ], "endShape" : { "a" : { "x" : 1736, "y" : 3349 }, "b" : { "x" : 1740, "y" : 3356 }, "c" : { "x" : 1744, "y" : 3349 }, "type" : "ARROW", "centre" : { "x" : 1744, "y" : 3349 } }, "reactionShape" : { "a" : { "x" : 1731, "y" : 3076 }, "b" : { "x" : 1743, "y" : 3088 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1737, "y" : 3082 } }, "inputs" : [ { "id" : 15783 } ], "outputs" : [ { "id" : 15784 } ], "activators" : [ { "id" : 15785, "points" : [ { "x" : 1833, "y" : 3189 } ] } ] }, { "id" : 15274, "reactomeId" : 9725009, "displayName" : "NPM1-ALK translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1211, "y" : 2538 }, "isDisease" : true, "minX" : 1142, "maxX" : 1281, "minY" : 2532, "maxY" : 2544, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1142, "y" : 2535 }, "to" : { "x" : 1211, "y" : 2538 } }, { "from" : { "x" : 1211, "y" : 2538 }, "to" : { "x" : 1281, "y" : 2534 } } ], "endShape" : { "a" : { "x" : 1274, "y" : 2538 }, "b" : { "x" : 1281, "y" : 2534 }, "c" : { "x" : 1274, "y" : 2530 }, "type" : "ARROW", "centre" : { "x" : 1274, "y" : 2530 } }, "reactionShape" : { "a" : { "x" : 1205, "y" : 2532 }, "b" : { "x" : 1217, "y" : 2544 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1211, "y" : 2538 } }, "inputs" : [ { "id" : 15275 } ], "outputs" : [ { "id" : 15260 } ], "activators" : [ { "id" : 15276, "points" : [ { "x" : 1116, "y" : 2434 } ] } ] }, { "id" : 174, "reactomeId" : 9700156, "displayName" : "Active ALK dimer binds IRS1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1469, "y" : 299 }, "isFadeOut" : true, "minX" : 1448, "maxX" : 1486, "minY" : 261, "maxY" : 304, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1448, "y" : 304 }, "to" : { "x" : 1469, "y" : 299 } }, { "from" : { "x" : 1469, "y" : 299 }, "to" : { "x" : 1486, "y" : 261 } } ], "endShape" : { "a" : { "x" : 1487, "y" : 269 }, "b" : { "x" : 1486, "y" : 261 }, "c" : { "x" : 1480, "y" : 266 }, "type" : "ARROW", "centre" : { "x" : 1480, "y" : 266 } }, "reactionShape" : { "c" : { "x" : 1469, "y" : 299 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1469, "y" : 299 } }, "inputs" : [ { "id" : 175, "points" : [ { "x" : 1421, "y" : 325 } ] }, { "id" : 15541, "points" : [ { "x" : 1232, "y" : 216 }, { "x" : 1353, "y" : 306 } ] } ], "outputs" : [ { "id" : 176 } ] }, { "id" : 177, "reactomeId" : 9700168, "displayName" : "Active ALK phosphorylates IRS1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1576, "y" : 252 }, "isFadeOut" : true, "minX" : 1559, "maxX" : 1656, "minY" : 246, "maxY" : 261, "segments" : [ { "from" : { "x" : 1559, "y" : 261 }, "to" : { "x" : 1576, "y" : 252 } }, { "from" : { "x" : 1576, "y" : 252 }, "to" : { "x" : 1656, "y" : 252 } } ], "reactionShape" : { "a" : { "x" : 1570, "y" : 246 }, "b" : { "x" : 1582, "y" : 258 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1576, "y" : 252 } }, "inputs" : [ { "id" : 178, "points" : [ { "x" : 1579, "y" : 283 } ] }, { "id" : 176, "points" : [ { "x" : 1543, "y" : 256 } ] } ], "outputs" : [ { "id" : 179, "points" : [ { "x" : 1710, "y" : 251 } ] }, { "id" : 180, "points" : [ { "x" : 1677, "y" : 283 } ] } ], "catalysts" : [ { "id" : 176, "points" : [ { "x" : 1529, "y" : 232 }, { "x" : 1574, "y" : 221 } ] } ] }, { "id" : 15283, "reactomeId" : 9725117, "displayName" : "ALK gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1044, "y" : 1367 }, "isFadeOut" : true, "minX" : 0, "maxX" : 1287, "minY" : 91, "maxY" : 1396, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 1287, "y" : 1396 }, "to" : { "x" : 1044, "y" : 1367 } }, { "from" : { "x" : 1044, "y" : 1367 }, "to" : { "x" : 803, "y" : 1380 } }, { "from" : { "x" : 803, "y" : 1380 }, "to" : { "x" : 0, "y" : 1337 } }, { "from" : { "x" : 0, "y" : 1337 }, "to" : { "x" : 4, "y" : 91 } }, { "from" : { "x" : 4, "y" : 91 }, "to" : { "x" : 130, "y" : 91 } } ], "endShape" : { "a" : { "x" : 123, "y" : 95 }, "b" : { "x" : 130, "y" : 91 }, "c" : { "x" : 123, "y" : 87 }, "type" : "ARROW", "centre" : { "x" : 123, "y" : 87 } }, "reactionShape" : { "a" : { "x" : 1038, "y" : 1361 }, "b" : { "x" : 1050, "y" : 1373 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1044, "y" : 1367 } }, "inputs" : [ { "id" : 15284 } ], "outputs" : [ { "id" : 9 } ], "activators" : [ { "id" : 15285, "points" : [ { "x" : 1242, "y" : 1320 } ] } ] }, { "id" : 14773, "reactomeId" : 9712079, "displayName" : "ALK mutants bind STAT3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 888, "y" : 1556 }, "isDisease" : true, "minX" : 882, "maxX" : 894, "minY" : 1537, "maxY" : 1584, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 887, "y" : 1537 }, "to" : { "x" : 888, "y" : 1556 } }, { "from" : { "x" : 888, "y" : 1556 }, "to" : { "x" : 892, "y" : 1584 } } ], "endShape" : { "a" : { "x" : 887, "y" : 1578 }, "b" : { "x" : 892, "y" : 1584 }, "c" : { "x" : 895, "y" : 1577 }, "type" : "ARROW", "centre" : { "x" : 895, "y" : 1577 } }, "reactionShape" : { "c" : { "x" : 888, "y" : 1556 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 888, "y" : 1556 } }, "inputs" : [ { "id" : 14774, "points" : [ { "x" : 831, "y" : 1502 } ] }, { "id" : 13898, "points" : [ { "x" : 918, "y" : 1054 } ] } ], "outputs" : [ { "id" : 14779 } ] }, { "id" : 181, "reactomeId" : 9700154, "displayName" : "Active ALK binds SHC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1693, "y" : 392 }, "isFadeOut" : true, "minX" : 1424, "maxX" : 1929, "minY" : 234, "maxY" : 404, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1424, "y" : 404 }, "to" : { "x" : 1693, "y" : 392 } }, { "from" : { "x" : 1693, "y" : 392 }, "to" : { "x" : 1929, "y" : 234 } } ], "endShape" : { "a" : { "x" : 1925, "y" : 241 }, "b" : { "x" : 1929, "y" : 234 }, "c" : { "x" : 1921, "y" : 235 }, "type" : "ARROW", "centre" : { "x" : 1921, "y" : 235 } }, "reactionShape" : { "c" : { "x" : 1693, "y" : 392 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1693, "y" : 392 } }, "inputs" : [ { "id" : 15541, "points" : [ { "x" : 1229, "y" : 216 } ] }, { "id" : 182, "points" : [ { "x" : 1389, "y" : 412 } ] } ], "outputs" : [ { "id" : 183 } ] }, { "id" : 184, "reactomeId" : 9700175, "displayName" : "Active ALK phosphorylates SHC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2063, "y" : 220 }, "isFadeOut" : true, "minX" : 2040, "maxX" : 2085, "minY" : 214, "maxY" : 226, "segments" : [ { "from" : { "x" : 2040, "y" : 222 }, "to" : { "x" : 2063, "y" : 220 } }, { "from" : { "x" : 2063, "y" : 220 }, "to" : { "x" : 2085, "y" : 218 } } ], "reactionShape" : { "a" : { "x" : 2057, "y" : 214 }, "b" : { "x" : 2069, "y" : 226 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2063, "y" : 220 } }, "inputs" : [ { "id" : 185, "points" : [ { "x" : 2015, "y" : 247 } ], "stoichiometry" : 3 }, { "id" : 183, "points" : [ { "x" : 2001, "y" : 220 }, { "x" : 2021, "y" : 221 } ] } ], "outputs" : [ { "id" : 186, "points" : [ { "x" : 2142, "y" : 215 } ] }, { "id" : 187, "points" : [ { "x" : 2111, "y" : 252 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 183, "points" : [ { "x" : 1962, "y" : 205 }, { "x" : 2003, "y" : 180 } ] } ] }, { "id" : 14780, "reactomeId" : 9712085, "displayName" : "ALK mutants phosphorylate STAT3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 908, "y" : 1675 }, "isDisease" : true, "minX" : 902, "maxX" : 914, "minY" : 1647, "maxY" : 1695, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 907, "y" : 1647 }, "to" : { "x" : 908, "y" : 1675 } }, { "from" : { "x" : 908, "y" : 1675 }, "to" : { "x" : 910, "y" : 1695 } } ], "reactionShape" : { "a" : { "x" : 902, "y" : 1669 }, "b" : { "x" : 914, "y" : 1681 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 908, "y" : 1675 } }, "inputs" : [ { "id" : 14779, "points" : [ { "x" : 900, "y" : 1627 } ] }, { "id" : 14781, "points" : [ { "x" : 973, "y" : 1640 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 14782, "points" : [ { "x" : 909, "y" : 1739 } ] }, { "id" : 14783, "points" : [ { "x" : 861, "y" : 1706 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 14779, "points" : [ { "x" : 878, "y" : 1627 }, { "x" : 849, "y" : 1656 } ] } ] }, { "id" : 16061, "reactomeId" : 9851133, "displayName" : "STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1893, "y" : 1676 }, "isDisease" : true, "minX" : 1874, "maxX" : 1936, "minY" : 1639, "maxY" : 1682, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1874, "y" : 1678 }, "to" : { "x" : 1893, "y" : 1676 } }, { "from" : { "x" : 1893, "y" : 1676 }, "to" : { "x" : 1936, "y" : 1639 } } ], "endShape" : { "a" : { "x" : 1933, "y" : 1647 }, "b" : { "x" : 1936, "y" : 1639 }, "c" : { "x" : 1928, "y" : 1640 }, "type" : "ARROW", "centre" : { "x" : 1928, "y" : 1640 } }, "reactionShape" : { "a" : { "x" : 1887, "y" : 1670 }, "b" : { "x" : 1899, "y" : 1682 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1893, "y" : 1676 } }, "inputs" : [ { "id" : 16062 } ], "outputs" : [ { "id" : 16063 } ], "inhibitors" : [ { "id" : 15844, "points" : [ { "x" : 2185, "y" : 1646 } ] }, { "id" : 13980, "points" : [ { "x" : 1659, "y" : 1511 } ] } ] }, { "id" : 15817, "reactomeId" : 9851122, "displayName" : "p-Y705,S727 STAT3 dimer binds NOTCH gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1479, "y" : 2082 }, "isDisease" : true, "minX" : 1363, "maxX" : 1583, "minY" : 2077, "maxY" : 2093, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1583, "y" : 2093 }, "to" : { "x" : 1479, "y" : 2082 } }, { "from" : { "x" : 1479, "y" : 2082 }, "to" : { "x" : 1363, "y" : 2093 } } ], "endShape" : { "a" : { "x" : 1370, "y" : 2088 }, "b" : { "x" : 1363, "y" : 2093 }, "c" : { "x" : 1370, "y" : 2096 }, "type" : "ARROW", "centre" : { "x" : 1370, "y" : 2096 } }, "reactionShape" : { "c" : { "x" : 1479, "y" : 2082 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1479, "y" : 2082 } }, "inputs" : [ { "id" : 13980, "points" : [ { "x" : 1632, "y" : 1511 } ] }, { "id" : 15818, "points" : [ { "x" : 1558, "y" : 2148 } ] } ], "outputs" : [ { "id" : 15819 } ] }, { "id" : 15820, "reactomeId" : 9851123, "displayName" : "NPM1-ALK- and p-STAT3-dependent NOTCH gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1310, "y" : 2161 }, "isDisease" : true, "minX" : 1005, "maxX" : 1558, "minY" : 2148, "maxY" : 2167, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1558, "y" : 2148 }, "to" : { "x" : 1310, "y" : 2161 } }, { "from" : { "x" : 1310, "y" : 2161 }, "to" : { "x" : 1005, "y" : 2165 } } ], "endShape" : { "a" : { "x" : 1012, "y" : 2161 }, "b" : { "x" : 1005, "y" : 2165 }, "c" : { "x" : 1012, "y" : 2169 }, "type" : "ARROW", "centre" : { "x" : 1012, "y" : 2169 } }, "reactionShape" : { "a" : { "x" : 1304, "y" : 2155 }, "b" : { "x" : 1316, "y" : 2167 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1310, "y" : 2161 } }, "inputs" : [ { "id" : 15818 } ], "outputs" : [ { "id" : 15821 } ], "activators" : [ { "id" : 15819, "points" : [ { "x" : 1310, "y" : 2128 } ] } ] }, { "id" : 220, "reactomeId" : 9700142, "displayName" : "Active ALK binds FRS2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1421, "y" : 199 }, "isFadeOut" : true, "minX" : 1401, "maxX" : 1448, "minY" : 194, "maxY" : 204, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1401, "y" : 199 }, "to" : { "x" : 1421, "y" : 199 } }, { "from" : { "x" : 1421, "y" : 199 }, "to" : { "x" : 1448, "y" : 197 } } ], "endShape" : { "a" : { "x" : 1441, "y" : 202 }, "b" : { "x" : 1448, "y" : 197 }, "c" : { "x" : 1441, "y" : 194 }, "type" : "ARROW", "centre" : { "x" : 1441, "y" : 194 } }, "reactionShape" : { "c" : { "x" : 1421, "y" : 199 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1421, "y" : 199 } }, "inputs" : [ { "id" : 15541, "points" : [ { "x" : 1278, "y" : 198 } ] }, { "id" : 221, "points" : [ { "x" : 1379, "y" : 259 } ] } ], "outputs" : [ { "id" : 222 } ] }, { "id" : 15325, "reactomeId" : 9725332, "displayName" : "MYC/MYCN bind the ALK gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1333, "y" : 1371 }, "isFadeOut" : true, "minX" : 1307, "maxX" : 1338, "minY" : 1330, "maxY" : 1396, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1326, "y" : 1396 }, "to" : { "x" : 1333, "y" : 1371 } }, { "from" : { "x" : 1333, "y" : 1371 }, "to" : { "x" : 1307, "y" : 1330 } } ], "endShape" : { "a" : { "x" : 1314, "y" : 1334 }, "b" : { "x" : 1307, "y" : 1330 }, "c" : { "x" : 1307, "y" : 1338 }, "type" : "ARROW", "centre" : { "x" : 1307, "y" : 1338 } }, "reactionShape" : { "c" : { "x" : 1333, "y" : 1371 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1333, "y" : 1371 } }, "inputs" : [ { "id" : 15284, "points" : [ { "x" : 1287, "y" : 1396 } ] }, { "id" : 15326, "points" : [ { "x" : 1350, "y" : 1397 } ] } ], "outputs" : [ { "id" : 15285 } ] }, { "id" : 14561, "reactomeId" : 9712083, "displayName" : "ALK mutants bind PI3KCA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 482, "y" : 476 }, "isDisease" : true, "minX" : 453, "maxX" : 505, "minY" : 471, "maxY" : 481, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 505, "y" : 473 }, "to" : { "x" : 482, "y" : 476 } }, { "from" : { "x" : 482, "y" : 476 }, "to" : { "x" : 453, "y" : 478 } } ], "endShape" : { "a" : { "x" : 460, "y" : 474 }, "b" : { "x" : 453, "y" : 478 }, "c" : { "x" : 460, "y" : 482 }, "type" : "ARROW", "centre" : { "x" : 460, "y" : 482 } }, "reactionShape" : { "c" : { "x" : 482, "y" : 476 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 482, "y" : 476 } }, "inputs" : [ { "id" : 14562, "points" : [ { "x" : 532, "y" : 451 } ] }, { "id" : 14570, "points" : [ { "x" : 691, "y" : 467 } ] } ], "outputs" : [ { "id" : 14564 } ] }, { "id" : 226, "reactomeId" : 9700164, "displayName" : "Active ALK phosphorylates FRS2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1676, "y" : 196 }, "isFadeOut" : true, "minX" : 1640, "maxX" : 1695, "minY" : 190, "maxY" : 202, "segments" : [ { "from" : { "x" : 1640, "y" : 196 }, "to" : { "x" : 1676, "y" : 196 } }, { "from" : { "x" : 1676, "y" : 196 }, "to" : { "x" : 1695, "y" : 197 } } ], "reactionShape" : { "a" : { "x" : 1670, "y" : 190 }, "b" : { "x" : 1682, "y" : 202 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1676, "y" : 196 } }, "inputs" : [ { "id" : 222, "points" : [ { "x" : 1555, "y" : 195 }, { "x" : 1600, "y" : 196 } ] }, { "id" : 178, "points" : [ { "x" : 1599, "y" : 283 } ], "stoichiometry" : 6 } ], "outputs" : [ { "id" : 228, "points" : [ { "x" : 1715, "y" : 194 } ] }, { "id" : 180, "points" : [ { "x" : 1688, "y" : 283 } ], "stoichiometry" : 6 } ], "catalysts" : [ { "id" : 222, "points" : [ { "x" : 1540, "y" : 180 }, { "x" : 1640, "y" : 154 } ] } ] }, { "id" : 14565, "reactomeId" : 9712078, "displayName" : "ALK mutants bind PI3KR1", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 848, "y" : 459 }, "isDisease" : true, "minX" : 824, "maxX" : 864, "minY" : 453, "maxY" : 465, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 864, "y" : 458 }, "to" : { "x" : 848, "y" : 459 } }, { "from" : { "x" : 848, "y" : 459 }, "to" : { "x" : 824, "y" : 460 } } ], "endShape" : { "a" : { "x" : 831, "y" : 456 }, "b" : { "x" : 824, "y" : 460 }, "c" : { "x" : 831, "y" : 464 }, "type" : "ARROW", "centre" : { "x" : 831, "y" : 464 } }, "reactionShape" : { "a" : { "x" : 842, "y" : 453 }, "b" : { "x" : 854, "y" : 465 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 848, "y" : 459 } }, "inputs" : [ { "id" : 14566, "points" : [ { "x" : 915, "y" : 444 } ] }, { "id" : 14567, "points" : [ { "x" : 897, "y" : 491 } ] } ], "outputs" : [ { "id" : 14570 } ] }, { "id" : 16617, "reactomeId" : 9851102, "displayName" : "NPM1-ALK- and PI3K-dependent MDM2 phosphorylation", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 657, "y" : 2823 }, "isDisease" : true, "minX" : 630, "maxX" : 679, "minY" : 2817, "maxY" : 2829, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 630, "y" : 2822 }, "to" : { "x" : 657, "y" : 2823 } }, { "from" : { "x" : 657, "y" : 2823 }, "to" : { "x" : 679, "y" : 2823 } } ], "reactionShape" : { "a" : { "x" : 651, "y" : 2817 }, "b" : { "x" : 663, "y" : 2829 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 657, "y" : 2823 } }, "inputs" : [ { "id" : 16618, "points" : [ { "x" : 616, "y" : 2829 } ] }, { "id" : 16619, "points" : [ { "x" : 608, "y" : 2798 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 16620, "points" : [ { "x" : 711, "y" : 2793 } ], "stoichiometry" : 2 }, { "id" : 16621, "points" : [ { "x" : 707, "y" : 2835 } ] } ], "activators" : [ { "id" : 16622, "points" : [ { "x" : 658, "y" : 2669 } ] } ] }, { "id" : 14574, "reactomeId" : 9712084, "displayName" : "PI3K synthesizes PIP3 downstream of ALK mutants", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 295, "y" : 488 }, "isDisease" : true, "minX" : 287, "maxX" : 301, "minY" : 449, "maxY" : 532, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 295, "y" : 449 }, "to" : { "x" : 295, "y" : 488 } }, { "from" : { "x" : 295, "y" : 488 }, "to" : { "x" : 287, "y" : 532 } } ], "reactionShape" : { "a" : { "x" : 289, "y" : 482 }, "b" : { "x" : 301, "y" : 494 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 295, "y" : 488 } }, "inputs" : [ { "id" : 14466, "points" : [ { "x" : 264, "y" : 413 } ] }, { "id" : 14467, "points" : [ { "x" : 352, "y" : 417 } ] } ], "outputs" : [ { "id" : 310, "points" : [ { "x" : 259, "y" : 562 } ] }, { "id" : 311, "points" : [ { "x" : 323, "y" : 528 } ] } ], "catalysts" : [ { "id" : 14564, "points" : [ { "x" : 332, "y" : 485 } ] } ] }, { "id" : 16366, "reactomeId" : 9851142, "displayName" : "TYK2-dependent STAT1 and STAT3 phosphorylation", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1292, "y" : 3239 }, "isDisease" : true, "minX" : 1286, "maxX" : 1298, "minY" : 3211, "maxY" : 3270, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1298, "y" : 3211 }, "to" : { "x" : 1292, "y" : 3239 } }, { "from" : { "x" : 1292, "y" : 3239 }, "to" : { "x" : 1288, "y" : 3270 } } ], "reactionShape" : { "a" : { "x" : 1286, "y" : 3233 }, "b" : { "x" : 1298, "y" : 3245 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1292, "y" : 3239 } }, "inputs" : [ { "id" : 16908, "points" : [ { "x" : 1322, "y" : 3190 } ], "stoichiometry" : 2 }, { "id" : 16909, "points" : [ { "x" : 1271, "y" : 3192 } ] } ], "outputs" : [ { "id" : 16370, "points" : [ { "x" : 1289, "y" : 3293 } ], "stoichiometry" : 2 }, { "id" : 16371, "points" : [ { "x" : 1347, "y" : 3292 } ] } ], "activators" : [ { "id" : 16184, "points" : [ { "x" : 1192, "y" : 3228 } ] } ] }, { "id" : 16120, "reactomeId" : 9851084, "displayName" : "JUNB dimer binds GZMB promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2273, "y" : 2695 }, "isDisease" : true, "minX" : 2232, "maxX" : 2308, "minY" : 2690, "maxY" : 2700, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2308, "y" : 2695 }, "to" : { "x" : 2273, "y" : 2695 } }, { "from" : { "x" : 2273, "y" : 2695 }, "to" : { "x" : 2232, "y" : 2696 } } ], "endShape" : { "a" : { "x" : 2239, "y" : 2692 }, "b" : { "x" : 2232, "y" : 2696 }, "c" : { "x" : 2239, "y" : 2700 }, "type" : "ARROW", "centre" : { "x" : 2239, "y" : 2700 } }, "reactionShape" : { "c" : { "x" : 2273, "y" : 2695 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2273, "y" : 2695 } }, "inputs" : [ { "id" : 16121, "points" : [ { "x" : 2388, "y" : 2766 } ] }, { "id" : 15410, "points" : [ { "x" : 2458, "y" : 2696 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 16122 } ] }, { "id" : 16123, "reactomeId" : 9851088, "displayName" : "JUNB- and NPM1-ALK-mediated GZMB gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2179, "y" : 2795 }, "isDisease" : true, "minX" : 2173, "maxX" : 2388, "minY" : 2766, "maxY" : 3169, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2388, "y" : 2766 }, "to" : { "x" : 2179, "y" : 2795 } }, { "from" : { "x" : 2179, "y" : 2795 }, "to" : { "x" : 2181, "y" : 3169 } } ], "endShape" : { "a" : { "x" : 2177, "y" : 3162 }, "b" : { "x" : 2181, "y" : 3169 }, "c" : { "x" : 2185, "y" : 3162 }, "type" : "ARROW", "centre" : { "x" : 2185, "y" : 3162 } }, "reactionShape" : { "a" : { "x" : 2173, "y" : 2789 }, "b" : { "x" : 2185, "y" : 2801 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2179, "y" : 2795 } }, "inputs" : [ { "id" : 16121 } ], "outputs" : [ { "id" : 16124 } ], "activators" : [ { "id" : 16122, "points" : [ { "x" : 2174, "y" : 2720 } ] } ] }, { "id" : 16126, "reactomeId" : 9851131, "displayName" : "NPM1-ALK-stimulated PRF1 gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2015, "y" : 2760 }, "isDisease" : true, "minX" : 1945, "maxX" : 2127, "minY" : 2754, "maxY" : 3174, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1945, "y" : 2776 }, "to" : { "x" : 2015, "y" : 2760 } }, { "from" : { "x" : 2015, "y" : 2760 }, "to" : { "x" : 2127, "y" : 3174 } } ], "endShape" : { "a" : { "x" : 2121, "y" : 3168 }, "b" : { "x" : 2127, "y" : 3174 }, "c" : { "x" : 2129, "y" : 3166 }, "type" : "ARROW", "centre" : { "x" : 2129, "y" : 3166 } }, "reactionShape" : { "a" : { "x" : 2009, "y" : 2754 }, "b" : { "x" : 2021, "y" : 2766 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2015, "y" : 2760 } }, "inputs" : [ { "id" : 16127 } ], "outputs" : [ { "id" : 16128 } ], "activators" : [ { "id" : 15260, "points" : [ { "x" : 1418, "y" : 2553 } ] } ] }, { "id" : 14846, "reactomeId" : 9701903, "displayName" : "ALK-, STAT3- and MECP2-dependent STAT5A gene repression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1418, "y" : 1805 }, "isDisease" : true, "minX" : 1315, "maxX" : 1465, "minY" : 1799, "maxY" : 1811, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1315, "y" : 1804 }, "to" : { "x" : 1418, "y" : 1805 } }, { "from" : { "x" : 1418, "y" : 1805 }, "to" : { "x" : 1465, "y" : 1806 } } ], "endShape" : { "a" : { "x" : 1458, "y" : 1810 }, "b" : { "x" : 1465, "y" : 1806 }, "c" : { "x" : 1458, "y" : 1802 }, "type" : "ARROW", "centre" : { "x" : 1458, "y" : 1802 } }, "reactionShape" : { "a" : { "x" : 1412, "y" : 1799 }, "b" : { "x" : 1424, "y" : 1811 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1418, "y" : 1805 } }, "inputs" : [ { "id" : 14837 } ], "outputs" : [ { "id" : 14847 } ], "inhibitors" : [ { "id" : 14839, "points" : [ { "x" : 1455, "y" : 1751 } ] } ] } ], "compartments" : [ { "id" : 2, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1639, "y" : 1737 }, "minX" : 231, "maxX" : 3047, "minY" : 77, "maxY" : 3397, "prop" : { "x" : 231, "y" : 77, "width" : 2816, "height" : 3320 }, "textPosition" : { "x" : 863, "y" : 355 }, "insets" : { "x" : 307, "y" : 254, "width" : 2710, "height" : 3102 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 10, 13, 28, 92, 93, 94, 103, 107, 108, 174, 175, 176, 177, 178, 179, 180, 183, 181, 182, 184, 185, 186, 187, 191, 193, 195, 221, 222, 220, 226, 228, 295, 296, 297, 310, 311, 307, 321, 326, 340, 341, 337, 338, 348, 352, 354, 355, 356, 357, 358, 359, 360, 361, 416, 13574, 13575, 13576, 13577, 13578, 13579, 13580, 13587, 13588, 13589, 13590, 13591, 13592, 30, 114, 116, 413, 13614, 13612, 13618, 13621, 13622, 13885, 13881, 13882, 13883, 13886, 13887, 13884, 13891, 13892, 13894, 13896, 13897, 13898, 13903, 13977, 14229, 14231, 14230, 14232, 14233, 14234, 14236, 14426, 14429, 14434, 14466, 14467, 14561, 14562, 14564, 14565, 14566, 14567, 14570, 14574, 14601, 14602, 14607, 14608, 14611, 14708, 14709, 14710, 14711, 14712, 14713, 14773, 14774, 14779, 14780, 14781, 14783, 14784, 14832, 14872, 14873, 14874, 14925, 14926, 15091, 15118, 15196, 15198, 15221, 15275, 14782, 15475, 15480, 27, 15512, 15513, 15519, 15520, 15521, 15522, 15523, 15541, 15543, 15544, 96, 336, 339, 106, 109, 7, 15276, 15654, 13907, 13978, 14101, 14078, 15283, 15784, 15790, 15792, 15891, 15911, 15912, 15910, 15785, 15436, 15434, 15728, 15821, 16007, 15997, 16125, 16183, 16184, 15462, 16212, 16213, 16214, 16215, 16366, 16370, 16371, 16394, 16395, 16396, 16438, 16439, 16617, 16618, 16619, 16620, 16621, 16622, 16229, 16005, 16761, 16763, 16910, 16909, 16908 ] }, { "id" : 16125, "reactomeId" : 8857380, "displayName" : "cytolytic granule lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2170, "y" : 3199 }, "minX" : 2058, "maxX" : 2283, "minY" : 3148, "maxY" : 3251, "prop" : { "x" : 2058, "y" : 3148, "width" : 225, "height" : 103 }, "textPosition" : { "x" : 2095, "y" : 3199 }, "insets" : { "x" : 2070, "y" : 3163, "width" : 197, "height" : 79 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 16124, 16128 ] }, { "id" : 13903, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1943, "y" : 2090 }, "minX" : 1174, "maxX" : 2713, "minY" : 1078, "maxY" : 3103, "prop" : { "x" : 1174, "y" : 1078, "width" : 1539, "height" : 2025 }, "textPosition" : { "x" : 1769, "y" : 1108 }, "insets" : { "x" : 1202, "y" : 1105, "width" : 1486, "height" : 1976 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 13980, 14015, 14016, 14017, 14018, 14020, 14034, 14035, 14036, 14054, 14070, 14069, 14083, 14084, 14086, 14087, 14090, 14089, 14088, 14091, 14094, 14095, 14096, 14097, 14098, 14099, 14100, 14092, 14839, 14837, 14838, 14846, 15258, 15259, 15260, 15261, 15262, 15263, 15264, 15266, 15265, 15284, 15285, 15326, 15325, 15408, 15409, 15410, 15413, 15460, 15461, 15474, 15472, 15473, 15550, 15551, 13979, 15631, 15632, 15274, 15653, 15671, 15672, 15673, 15435, 15674, 15723, 15724, 15726, 15727, 15737, 15738, 15740, 15741, 15746, 15748, 15747, 15625, 15773, 15783, 15817, 15818, 15819, 15820, 15838, 15844, 15883, 15885, 15890, 15926, 15927, 15782, 15925, 15909, 15991, 15992, 15998, 16003, 16020, 16061, 16063, 16120, 16121, 16122, 16123, 14847, 15989, 16062, 15884, 16126, 16127, 14777, 16182, 16181, 16398, 16419, 16422, 16421, 16425, 16424, 16430, 16431, 16432, 16452, 16659, 16664, 16682, 16372, 16769, 16813, 16906, 16907, 17163, 17176, 17177, 17178, 17180 ] } ], "notes" : [ ], "links" : [ { "id" : 193, "renderableClass" : "Interaction", "position" : { "x" : 1932, "y" : 309 }, "isFadeOut" : true, "minX" : 1805, "maxX" : 2059, "minY" : 266, "maxY" : 353, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1805, "y" : 266 }, "to" : { "x" : 2059, "y" : 353 } } ], "endShape" : { "a" : { "x" : 2051, "y" : 355 }, "b" : { "x" : 2059, "y" : 353 }, "c" : { "x" : 2054, "y" : 347 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2054, "y" : 347 } }, "reactionShape" : { "a" : { "x" : 1926, "y" : 303 }, "b" : { "x" : 1938, "y" : 315 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1932, "y" : 309 } }, "inputs" : [ { "id" : 179 } ], "outputs" : [ { "id" : 191 } ] }, { "id" : 195, "renderableClass" : "Interaction", "position" : { "x" : 2163, "y" : 289 }, "isFadeOut" : true, "minX" : 2137, "maxX" : 2189, "minY" : 236, "maxY" : 343, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2189, "y" : 236 }, "to" : { "x" : 2137, "y" : 343 } } ], "endShape" : { "a" : { "x" : 2136, "y" : 335 }, "b" : { "x" : 2137, "y" : 343 }, "c" : { "x" : 2144, "y" : 339 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2144, "y" : 339 } }, "reactionShape" : { "a" : { "x" : 2157, "y" : 283 }, "b" : { "x" : 2169, "y" : 295 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2163, "y" : 289 } }, "inputs" : [ { "id" : 186 } ], "outputs" : [ { "id" : 191 } ] }, { "id" : 326, "renderableClass" : "Interaction", "position" : { "x" : 495, "y" : 578 }, "minX" : 291, "maxX" : 699, "minY" : 572, "maxY" : 584, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 291, "y" : 579 }, "to" : { "x" : 699, "y" : 578 } } ], "endShape" : { "a" : { "x" : 692, "y" : 582 }, "b" : { "x" : 699, "y" : 578 }, "c" : { "x" : 692, "y" : 574 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 692, "y" : 574 } }, "reactionShape" : { "a" : { "x" : 489, "y" : 572 }, "b" : { "x" : 501, "y" : 584 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 495, "y" : 578 } }, "inputs" : [ { "id" : 310 } ], "outputs" : [ { "id" : 321 } ] }, { "id" : 15623, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 146, "y" : 1854 }, "isFadeOut" : true, "minX" : 121, "maxX" : 171, "minY" : 1730, "maxY" : 1979, "segments" : [ { "from" : { "x" : 171, "y" : 1730 }, "to" : { "x" : 121, "y" : 1979 } } ], "reactionShape" : { "a" : { "x" : 140, "y" : 1848 }, "b" : { "x" : 152, "y" : 1860 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 146, "y" : 1854 } }, "inputs" : [ { "id" : 8 } ], "outputs" : [ { "id" : 15622 } ] }, { "id" : 16007, "renderableClass" : "Interaction", "position" : { "x" : 2836, "y" : 2756 }, "minX" : 2830, "maxX" : 2842, "minY" : 2705, "maxY" : 2807, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2835, "y" : 2705 }, "to" : { "x" : 2838, "y" : 2807 } } ], "endShape" : { "a" : { "x" : 2834, "y" : 2800 }, "b" : { "x" : 2838, "y" : 2807 }, "c" : { "x" : 2842, "y" : 2800 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2842, "y" : 2800 } }, "reactionShape" : { "a" : { "x" : 2830, "y" : 2750 }, "b" : { "x" : 2842, "y" : 2762 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2836, "y" : 2756 } }, "inputs" : [ { "id" : 15436 } ], "outputs" : [ { "id" : 16005 } ] }, { "id" : 15624, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 111, "y" : 1853 }, "isFadeOut" : true, "minX" : 104, "maxX" : 118, "minY" : 1728, "maxY" : 1979, "segments" : [ { "from" : { "x" : 104, "y" : 1728 }, "to" : { "x" : 118, "y" : 1979 } } ], "reactionShape" : { "a" : { "x" : 105, "y" : 1847 }, "b" : { "x" : 117, "y" : 1859 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 111, "y" : 1853 } }, "inputs" : [ { "id" : 12 } ], "outputs" : [ { "id" : 15622 } ] }, { "id" : 15118, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1055, "y" : 303 }, "minX" : 812, "maxX" : 1105, "minY" : 89, "maxY" : 1453, "segments" : [ { "from" : { "x" : 812, "y" : 1453 }, "to" : { "x" : 1105, "y" : 484 } }, { "from" : { "x" : 1105, "y" : 484 }, "to" : { "x" : 1005, "y" : 122 } }, { "from" : { "x" : 1005, "y" : 122 }, "to" : { "x" : 916, "y" : 89 } } ], "reactionShape" : { "a" : { "x" : 1049, "y" : 297 }, "b" : { "x" : 1061, "y" : 309 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1055, "y" : 303 } }, "inputs" : [ { "id" : 14774 } ], "outputs" : [ { "id" : 13622 } ] }, { "id" : 16910, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1089, "y" : 2105 }, "minX" : 920, "maxX" : 1258, "minY" : 1054, "maxY" : 3157, "segments" : [ { "from" : { "x" : 920, "y" : 1054 }, "to" : { "x" : 1258, "y" : 3157 } } ], "reactionShape" : { "a" : { "x" : 1083, "y" : 2099 }, "b" : { "x" : 1095, "y" : 2111 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1089, "y" : 2105 } }, "inputs" : [ { "id" : 13898 } ], "outputs" : [ { "id" : 16909 } ] }, { "id" : 14231, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1747, "y" : 814 }, "minX" : 1736, "maxX" : 1758, "minY" : 784, "maxY" : 844, "segments" : [ { "from" : { "x" : 1736, "y" : 844 }, "to" : { "x" : 1758, "y" : 784 } } ], "reactionShape" : { "a" : { "x" : 1741, "y" : 808 }, "b" : { "x" : 1753, "y" : 820 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1747, "y" : 814 } }, "inputs" : [ { "id" : 14230 } ], "outputs" : [ { "id" : 13579 } ] }, { "id" : 15196, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1086, "y" : 499 }, "minX" : 909, "maxX" : 1595, "minY" : 89, "maxY" : 622, "segments" : [ { "from" : { "x" : 1595, "y" : 622 }, "to" : { "x" : 1337, "y" : 579 } }, { "from" : { "x" : 1337, "y" : 579 }, "to" : { "x" : 1086, "y" : 499 } }, { "from" : { "x" : 1086, "y" : 499 }, "to" : { "x" : 996, "y" : 128 } }, { "from" : { "x" : 996, "y" : 128 }, "to" : { "x" : 909, "y" : 89 } } ], "reactionShape" : { "a" : { "x" : 1080, "y" : 493 }, "b" : { "x" : 1092, "y" : 505 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1086, "y" : 499 } }, "inputs" : [ { "id" : 14784 } ], "outputs" : [ { "id" : 13622 } ] }, { "id" : 17180, "renderableClass" : "Interaction", "position" : { "x" : 1459, "y" : 2294 }, "minX" : 1453, "maxX" : 1465, "minY" : 2280, "maxY" : 2308, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1460, "y" : 2308 }, "to" : { "x" : 1459, "y" : 2280 } } ], "endShape" : { "a" : { "x" : 1463, "y" : 2287 }, "b" : { "x" : 1459, "y" : 2280 }, "c" : { "x" : 1455, "y" : 2287 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1455, "y" : 2287 } }, "reactionShape" : { "a" : { "x" : 1453, "y" : 2288 }, "b" : { "x" : 1465, "y" : 2300 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1459, "y" : 2294 } }, "inputs" : [ { "id" : 17178 } ], "outputs" : [ { "id" : 16813 } ] }, { "id" : 93, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 268, "y" : 2163 }, "isFadeOut" : true, "minX" : 237, "maxX" : 299, "minY" : 2136, "maxY" : 2191, "segments" : [ { "from" : { "x" : 237, "y" : 2136 }, "to" : { "x" : 299, "y" : 2191 } } ], "reactionShape" : { "a" : { "x" : 262, "y" : 2157 }, "b" : { "x" : 274, "y" : 2169 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 268, "y" : 2163 } }, "inputs" : [ { "id" : 30 } ], "outputs" : [ { "id" : 92 } ] }, { "id" : 94, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 320, "y" : 2149 }, "isFadeOut" : true, "minX" : 314, "maxX" : 326, "minY" : 2107, "maxY" : 2191, "segments" : [ { "from" : { "x" : 323, "y" : 2107 }, "to" : { "x" : 318, "y" : 2191 } } ], "reactionShape" : { "a" : { "x" : 314, "y" : 2143 }, "b" : { "x" : 326, "y" : 2155 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 320, "y" : 2149 } }, "inputs" : [ { "id" : 28 } ], "outputs" : [ { "id" : 92 } ] }, { "id" : 15198, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1710, "y" : 696 }, "minX" : 1673, "maxX" : 1748, "minY" : 657, "maxY" : 735, "segments" : [ { "from" : { "x" : 1673, "y" : 657 }, "to" : { "x" : 1748, "y" : 735 } } ], "reactionShape" : { "a" : { "x" : 1704, "y" : 690 }, "b" : { "x" : 1716, "y" : 702 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1710, "y" : 696 } }, "inputs" : [ { "id" : 14784 } ], "outputs" : [ { "id" : 13579 } ] }, { "id" : 15521, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 422, "y" : 1853 }, "isFadeOut" : true, "minX" : 234, "maxX" : 714, "minY" : 233, "maxY" : 2107, "segments" : [ { "from" : { "x" : 234, "y" : 2107 }, "to" : { "x" : 422, "y" : 1853 } }, { "from" : { "x" : 422, "y" : 1853 }, "to" : { "x" : 714, "y" : 233 } } ], "reactionShape" : { "a" : { "x" : 416, "y" : 1847 }, "b" : { "x" : 428, "y" : 1859 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 422, "y" : 1853 } }, "inputs" : [ { "id" : 30 } ], "outputs" : [ { "id" : 15520 } ] }, { "id" : 354, "renderableClass" : "Interaction", "position" : { "x" : 348, "y" : 1149 }, "isFadeOut" : true, "minX" : 313, "maxX" : 384, "minY" : 1140, "maxY" : 1158, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 313, "y" : 1140 }, "to" : { "x" : 384, "y" : 1158 } } ], "endShape" : { "a" : { "x" : 376, "y" : 1160 }, "b" : { "x" : 384, "y" : 1158 }, "c" : { "x" : 378, "y" : 1152 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 378, "y" : 1152 } }, "reactionShape" : { "a" : { "x" : 342, "y" : 1143 }, "b" : { "x" : 354, "y" : 1155 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 348, "y" : 1149 } }, "inputs" : [ { "id" : 341 } ], "outputs" : [ { "id" : 352 } ] }, { "id" : 14434, "renderableClass" : "Interaction", "position" : { "x" : 390, "y" : 1114 }, "minX" : 363, "maxX" : 417, "minY" : 1087, "maxY" : 1142, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 363, "y" : 1087 }, "to" : { "x" : 417, "y" : 1142 } } ], "endShape" : { "a" : { "x" : 409, "y" : 1140 }, "b" : { "x" : 417, "y" : 1142 }, "c" : { "x" : 415, "y" : 1134 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 415, "y" : 1134 } }, "reactionShape" : { "a" : { "x" : 384, "y" : 1108 }, "b" : { "x" : 396, "y" : 1120 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 390, "y" : 1114 } }, "inputs" : [ { "id" : 14429 } ], "outputs" : [ { "id" : 352 } ] }, { "id" : 15522, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 468, "y" : 1911 }, "isFadeOut" : true, "minX" : 333, "maxX" : 715, "minY" : 233, "maxY" : 2078, "segments" : [ { "from" : { "x" : 333, "y" : 2078 }, "to" : { "x" : 468, "y" : 1911 } }, { "from" : { "x" : 468, "y" : 1911 }, "to" : { "x" : 715, "y" : 233 } } ], "reactionShape" : { "a" : { "x" : 462, "y" : 1905 }, "b" : { "x" : 474, "y" : 1917 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 468, "y" : 1911 } }, "inputs" : [ { "id" : 28 } ], "outputs" : [ { "id" : 15520 } ] }, { "id" : 15523, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 600, "y" : 187 }, "isFadeOut" : true, "minX" : 547, "maxX" : 653, "minY" : 177, "maxY" : 197, "segments" : [ { "from" : { "x" : 547, "y" : 177 }, "to" : { "x" : 653, "y" : 197 } } ], "reactionShape" : { "a" : { "x" : 594, "y" : 181 }, "b" : { "x" : 606, "y" : 193 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 600, "y" : 187 } }, "inputs" : [ { "id" : 15512 } ], "outputs" : [ { "id" : 15520 } ] }, { "id" : 16229, "renderableClass" : "Interaction", "position" : { "x" : 1279, "y" : 3427 }, "minX" : 1091, "maxX" : 1467, "minY" : 3390, "maxY" : 3464, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1091, "y" : 3464 }, "to" : { "x" : 1467, "y" : 3390 } } ], "endShape" : { "a" : { "x" : 1461, "y" : 3395 }, "b" : { "x" : 1467, "y" : 3390 }, "c" : { "x" : 1459, "y" : 3387 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1459, "y" : 3387 } }, "reactionShape" : { "a" : { "x" : 1273, "y" : 3421 }, "b" : { "x" : 1285, "y" : 3433 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1279, "y" : 3427 } }, "inputs" : [ { "id" : 16216 } ], "outputs" : [ { "id" : 15790 } ] }, { "id" : 15271, "renderableClass" : "Interaction", "position" : { "x" : 3099, "y" : 1369 }, "minX" : 1706, "maxX" : 3136, "minY" : 376, "maxY" : 2348, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2190, "y" : 376 }, "to" : { "x" : 3063, "y" : 399 } }, { "from" : { "x" : 3063, "y" : 399 }, "to" : { "x" : 3136, "y" : 2340 } }, { "from" : { "x" : 3136, "y" : 2340 }, "to" : { "x" : 1706, "y" : 2348 } } ], "endShape" : { "a" : { "x" : 1713, "y" : 2344 }, "b" : { "x" : 1706, "y" : 2348 }, "c" : { "x" : 1713, "y" : 2352 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1713, "y" : 2352 } }, "reactionShape" : { "a" : { "x" : 3093, "y" : 1363 }, "b" : { "x" : 3105, "y" : 1375 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3099, "y" : 1369 } }, "inputs" : [ { "id" : 191 } ], "outputs" : [ { "id" : 15266 } ] }, { "id" : 14832, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1609, "y" : 645 }, "minX" : 1479, "maxX" : 1739, "minY" : 555, "maxY" : 735, "segments" : [ { "from" : { "x" : 1479, "y" : 555 }, "to" : { "x" : 1739, "y" : 735 } } ], "reactionShape" : { "a" : { "x" : 1603, "y" : 639 }, "b" : { "x" : 1615, "y" : 651 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1609, "y" : 645 } }, "inputs" : [ { "id" : 15475 } ], "outputs" : [ { "id" : 13579 } ] }, { "id" : 15792, "renderableClass" : "Interaction", "position" : { "x" : 1655, "y" : 3372 }, "minX" : 1598, "maxX" : 1713, "minY" : 3366, "maxY" : 3378, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1713, "y" : 3370 }, "to" : { "x" : 1598, "y" : 3375 } } ], "endShape" : { "a" : { "x" : 1605, "y" : 3371 }, "b" : { "x" : 1598, "y" : 3375 }, "c" : { "x" : 1605, "y" : 3379 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1605, "y" : 3379 } }, "reactionShape" : { "a" : { "x" : 1649, "y" : 3366 }, "b" : { "x" : 1661, "y" : 3378 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1655, "y" : 3372 } }, "inputs" : [ { "id" : 15784 } ], "outputs" : [ { "id" : 15790 } ] }, { "id" : 15091, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1030, "y" : 321 }, "minX" : 905, "maxX" : 1069, "minY" : 89, "maxY" : 512, "segments" : [ { "from" : { "x" : 977, "y" : 512 }, "to" : { "x" : 1069, "y" : 508 } }, { "from" : { "x" : 1069, "y" : 508 }, "to" : { "x" : 992, "y" : 134 } }, { "from" : { "x" : 992, "y" : 134 }, "to" : { "x" : 905, "y" : 89 } } ], "reactionShape" : { "a" : { "x" : 1024, "y" : 315 }, "b" : { "x" : 1036, "y" : 327 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1030, "y" : 321 } }, "inputs" : [ { "id" : 14567 } ], "outputs" : [ { "id" : 13622 } ] }, { "id" : 15221, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1341, "y" : 637 }, "minX" : 977, "maxX" : 1706, "minY" : 531, "maxY" : 743, "segments" : [ { "from" : { "x" : 977, "y" : 531 }, "to" : { "x" : 1706, "y" : 743 } } ], "reactionShape" : { "a" : { "x" : 1335, "y" : 631 }, "b" : { "x" : 1347, "y" : 643 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1341, "y" : 637 } }, "inputs" : [ { "id" : 14567 } ], "outputs" : [ { "id" : 13579 } ] }, { "id" : 15415, "renderableClass" : "Interaction", "position" : { "x" : 3148, "y" : 1422 }, "minX" : 2091, "maxX" : 3196, "minY" : 372, "maxY" : 2559, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2190, "y" : 374 }, "to" : { "x" : 3100, "y" : 372 } }, { "from" : { "x" : 3100, "y" : 372 }, "to" : { "x" : 3196, "y" : 2473 } }, { "from" : { "x" : 3196, "y" : 2473 }, "to" : { "x" : 2091, "y" : 2559 } } ], "endShape" : { "a" : { "x" : 2098, "y" : 2554 }, "b" : { "x" : 2091, "y" : 2559 }, "c" : { "x" : 2098, "y" : 2562 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2098, "y" : 2562 } }, "reactionShape" : { "a" : { "x" : 3142, "y" : 1416 }, "b" : { "x" : 3154, "y" : 1428 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3148, "y" : 1422 } }, "inputs" : [ { "id" : 191 } ], "outputs" : [ { "id" : 15413 } ] }, { "id" : 15543, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 771, "y" : 1328 }, "isFadeOut" : true, "minX" : 330, "maxX" : 1213, "minY" : 216, "maxY" : 2440, "segments" : [ { "from" : { "x" : 1213, "y" : 216 }, "to" : { "x" : 330, "y" : 2440 } } ], "reactionShape" : { "a" : { "x" : 765, "y" : 1322 }, "b" : { "x" : 777, "y" : 1334 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 771, "y" : 1328 } }, "inputs" : [ { "id" : 15541 } ], "outputs" : [ { "id" : 96 } ] }, { "id" : 14777, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1285, "y" : 1118 }, "minX" : 831, "maxX" : 1740, "minY" : 784, "maxY" : 1453, "segments" : [ { "from" : { "x" : 831, "y" : 1453 }, "to" : { "x" : 1740, "y" : 784 } } ], "reactionShape" : { "a" : { "x" : 1279, "y" : 1112 }, "b" : { "x" : 1291, "y" : 1124 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1285, "y" : 1118 } }, "inputs" : [ { "id" : 14774 } ], "outputs" : [ { "id" : 13579 } ] }, { "id" : 16763, "renderableClass" : "Interaction", "position" : { "x" : 743, "y" : 2927 }, "minX" : 737, "maxX" : 749, "minY" : 2881, "maxY" : 2974, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 744, "y" : 2881 }, "to" : { "x" : 743, "y" : 2974 } } ], "endShape" : { "a" : { "x" : 739, "y" : 2967 }, "b" : { "x" : 743, "y" : 2974 }, "c" : { "x" : 747, "y" : 2967 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 747, "y" : 2967 } }, "reactionShape" : { "a" : { "x" : 737, "y" : 2921 }, "b" : { "x" : 749, "y" : 2933 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 743, "y" : 2927 } }, "inputs" : [ { "id" : 16621 } ], "outputs" : [ { "id" : 16761 } ] } ], "shadows" : [ { "id" : 17181, "reactomeId" : 9725371, "displayName" : "Nuclear events stimulated by ALK signaling in cancer", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1729, "y" : 2421 }, "minX" : 428, "maxX" : 3031, "minY" : 1451, "maxY" : 3392, "prop" : { "x" : 428, "y" : 1451, "width" : 2603, "height" : 1941 }, "points" : [ { "x" : 428, "y" : 1451 }, { "x" : 3031, "y" : 1451 }, { "x" : 3031, "y" : 3392 }, { "x" : 428, "y" : 3392 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 3196, "minY" : 0, "maxY" : 3482, "disease" : true }