{ "dbId" : 9717301, "stableId" : "R-HSA-9717301", "displayName" : "NVP-TAE684-resistant ALK mutants", "forNormalDraw" : false, "nodes" : [ { "id" : 14083, "reactomeId" : 8948427, "displayName" : "HIF1A gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1552, "y" : 1323 }, "isFadeOut" : true, "minX" : 1460, "maxX" : 1599, "minY" : 1279, "maxY" : 1375, "prop" : { "x" : 1515, "y" : 1297, "width" : 75, "height" : 52 }, "textPosition" : { "x" : 1529, "y" : 1324 }, "connectors" : [ { "edgeId" : 14095, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1599, "y" : 1299 }, "to" : { "x" : 1540, "y" : 1279 } }, { "from" : { "x" : 1540, "y" : 1279 }, "to" : { "x" : 1492, "y" : 1282 } }, { "from" : { "x" : 1492, "y" : 1282 }, "to" : { "x" : 1460, "y" : 1375 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14096, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1597, "y" : 1295 }, "b" : { "x" : 1590, "y" : 1299 }, "c" : { "x" : 1597, "y" : 1303 }, "type" : "ARROW", "centre" : { "x" : 1597, "y" : 1303 } } }, { "id" : 14084, "reactomeId" : 9701459, "displayName" : "p-Y705, S727 STAT3 dimer:HIF1A gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1515, "y" : 1166 }, "isFadeOut" : true, "minX" : 1452, "maxX" : 1632, "minY" : 1141, "maxY" : 1302, "prop" : { "x" : 1452, "y" : 1141, "width" : 127, "height" : 51 }, "textPosition" : { "x" : 1452, "y" : 1143 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 14095, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14096, "type" : "ACTIVATOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1566, "y" : 1195 }, "to" : { "x" : 1621, "y" : 1219 } }, { "from" : { "x" : 1621, "y" : 1219 }, "to" : { "x" : 1629, "y" : 1302 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1624, "y" : 1295 }, "b" : { "x" : 1629, "y" : 1302 }, "c" : { "x" : 1632, "y" : 1295 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1632, "y" : 1295 } } } ] }, { "id" : 15622, "reactomeId" : 9699986, "displayName" : "PTN,MDK", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 119, "y" : 1990 }, "isFadeOut" : true, "minX" : 87, "maxX" : 151, "minY" : 1979, "maxY" : 2234, "prop" : { "x" : 87, "y" : 1979, "width" : 64, "height" : 23 }, "textPosition" : { "x" : 88, "y" : 1980 }, "connectors" : [ { "edgeId" : 15621, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 118, "y" : 2008 }, "to" : { "x" : 113, "y" : 2234 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14086, "reactomeId" : 1234135, "displayName" : "HIF1A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1680, "y" : 1312 }, "isFadeOut" : true, "minX" : 1659, "maxX" : 1702, "minY" : 1301, "maxY" : 1324, "prop" : { "x" : 1659, "y" : 1301, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 1659, "y" : 1302 }, "connectors" : [ { "edgeId" : 14096, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14087, "reactomeId" : 205005, "displayName" : "Histone deacetylase", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1832, "y" : 1341 }, "isFadeOut" : true, "minX" : 1770, "maxX" : 1894, "minY" : 1330, "maxY" : 1416, "prop" : { "x" : 1770, "y" : 1330, "width" : 124, "height" : 23 }, "textPosition" : { "x" : 1790, "y" : 1324 }, "connectors" : [ { "edgeId" : 14089, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1832, "y" : 1359 }, "to" : { "x" : 1834, "y" : 1408 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1834, "y" : 1412 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1834, "y" : 1412 } } } ] }, { "id" : 8, "reactomeId" : 201500, "displayName" : "PTN", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 174, "y" : 1709 }, "isFadeOut" : true, "minX" : 158, "maxX" : 227, "minY" : 1698, "maxY" : 1721, "prop" : { "x" : 158, "y" : 1698, "width" : 33, "height" : 23 }, "textPosition" : { "x" : 158, "y" : 1699 }, "connectors" : [ { "edgeId" : 7, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 194, "y" : 1710 }, "to" : { "x" : 227, "y" : 1715 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 9, "reactomeId" : 201502, "displayName" : "ALK", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 148, "y" : 85 }, "isFadeOut" : true, "minX" : 76, "maxX" : 245, "minY" : 74, "maxY" : 1726, "prop" : { "x" : 133, "y" : 74, "width" : 31, "height" : 23 }, "textPosition" : { "x" : 134, "y" : 75 }, "connectors" : [ { "edgeId" : 7, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 147, "y" : 100 }, "to" : { "x" : 120, "y" : 462 } }, { "from" : { "x" : 120, "y" : 462 }, "to" : { "x" : 227, "y" : 1715 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 11, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 144, "y" : 100 }, "to" : { "x" : 76, "y" : 328 } }, { "from" : { "x" : 76, "y" : 328 }, "to" : { "x" : 102, "y" : 1552 } }, { "from" : { "x" : 102, "y" : 1552 }, "to" : { "x" : 141, "y" : 1726 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15513, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 167, "y" : 89 }, "to" : { "x" : 245, "y" : 116 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 200, "y" : 96 }, "b" : { "x" : 212, "y" : 108 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 206, "y" : 102 } } } }, { "edgeId" : 15283, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 10, "reactomeId" : 201520, "displayName" : "PTN:ALK", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 271, "y" : 1779 }, "isFadeOut" : true, "minX" : 242, "maxX" : 301, "minY" : 1768, "maxY" : 1972, "prop" : { "x" : 242, "y" : 1768, "width" : 59, "height" : 23 }, "textPosition" : { "x" : 243, "y" : 1770 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 7, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 27, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 271, "y" : 1794 }, "to" : { "x" : 278, "y" : 1912 } }, { "from" : { "x" : 278, "y" : 1912 }, "to" : { "x" : 277, "y" : 1972 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14090, "reactomeId" : 113518, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1913, "y" : 1376 }, "isFadeOut" : true, "minX" : 1873, "maxX" : 1935, "minY" : 1361, "maxY" : 1426, "prop" : { "x" : 1892, "y" : 1361, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1896, "y" : 1366 }, "connectors" : [ { "edgeId" : 14089, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1900, "y" : 1395 }, "to" : { "x" : 1873, "y" : 1426 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 12, "reactomeId" : 2160953, "displayName" : "MDK", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 104, "y" : 1707 }, "isFadeOut" : true, "minX" : 86, "maxX" : 141, "minY" : 1696, "maxY" : 1726, "prop" : { "x" : 86, "y" : 1696, "width" : 36, "height" : 23 }, "textPosition" : { "x" : 87, "y" : 1697 }, "connectors" : [ { "edgeId" : 11, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 125, "y" : 1716 }, "to" : { "x" : 141, "y" : 1726 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13, "reactomeId" : 9667909, "displayName" : "MDK:ALK", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 216, "y" : 1817 }, "isFadeOut" : true, "minX" : 144, "maxX" : 247, "minY" : 1806, "maxY" : 2017, "prop" : { "x" : 185, "y" : 1806, "width" : 62, "height" : 23 }, "textPosition" : { "x" : 186, "y" : 1808 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 11, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 29, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 208, "y" : 1832 }, "to" : { "x" : 144, "y" : 1929 } }, { "from" : { "x" : 144, "y" : 1929 }, "to" : { "x" : 206, "y" : 2017 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14098, "reactomeId" : 9701419, "displayName" : "CD274 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1943, "y" : 1247 }, "isFadeOut" : true, "minX" : 1902, "maxX" : 2031, "minY" : 1177, "maxY" : 1273, "prop" : { "x" : 1902, "y" : 1221, "width" : 82, "height" : 52 }, "textPosition" : { "x" : 1916, "y" : 1248 }, "connectors" : [ { "edgeId" : 14097, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1993, "y" : 1223 }, "to" : { "x" : 2031, "y" : 1177 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14100, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1991, "y" : 1219 }, "b" : { "x" : 1984, "y" : 1223 }, "c" : { "x" : 1991, "y" : 1227 }, "type" : "ARROW", "centre" : { "x" : 1991, "y" : 1227 } } }, { "id" : 14099, "reactomeId" : 9701462, "displayName" : "p-Y705, S727 STAT3 dimer:CD274 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2222, "y" : 1172 }, "isFadeOut" : true, "minX" : 2155, "maxX" : 2289, "minY" : 1147, "maxY" : 1229, "prop" : { "x" : 2155, "y" : 1147, "width" : 134, "height" : 51 }, "textPosition" : { "x" : 2154, "y" : 1163 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 14097, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14100, "type" : "ACTIVATOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2225, "y" : 1201 }, "to" : { "x" : 2229, "y" : 1229 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2224, "y" : 1223 }, "b" : { "x" : 2229, "y" : 1229 }, "c" : { "x" : 2232, "y" : 1222 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2232, "y" : 1222 } } } ] }, { "id" : 14101, "reactomeId" : 3211776, "displayName" : "CD274", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2980, "y" : 1241 }, "isFadeOut" : true, "minX" : 2955, "maxX" : 3005, "minY" : 1230, "maxY" : 1253, "prop" : { "x" : 2955, "y" : 1230, "width" : 50, "height" : 23 }, "textPosition" : { "x" : 2955, "y" : 1231 }, "connectors" : [ { "edgeId" : 14100, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 28, "reactomeId" : 201496, "displayName" : "PTN:ALK dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 324, "y" : 2086 }, "isFadeOut" : true, "minX" : 276, "maxX" : 373, "minY" : 2075, "maxY" : 2098, "prop" : { "x" : 276, "y" : 2075, "width" : 97, "height" : 23 }, "textPosition" : { "x" : 276, "y" : 2077 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 27, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 30, "reactomeId" : 9699997, "displayName" : "MDK:ALK dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 226, "y" : 2115 }, "isFadeOut" : true, "minX" : 176, "maxX" : 276, "minY" : 2104, "maxY" : 2127, "prop" : { "x" : 176, "y" : 2104, "width" : 100, "height" : 23 }, "textPosition" : { "x" : 177, "y" : 2106 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 29, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 296, "reactomeId" : 74693, "displayName" : "PI3K", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 806, "y" : 340 }, "isFadeOut" : true, "minX" : 712, "maxX" : 824, "minY" : 329, "maxY" : 352, "prop" : { "x" : 789, "y" : 329, "width" : 35, "height" : 23 }, "textPosition" : { "x" : 789, "y" : 331 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 295, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 786, "y" : 338 }, "to" : { "x" : 712, "y" : 331 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 297, "reactomeId" : 9699995, "displayName" : "Active ALK:PI3K", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 212, "y" : 332 }, "isFadeOut" : true, "minX" : 163, "maxX" : 261, "minY" : 321, "maxY" : 482, "prop" : { "x" : 163, "y" : 321, "width" : 98, "height" : 23 }, "textPosition" : { "x" : 175, "y" : 309 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 295, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 307, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 207, "y" : 347 }, "to" : { "x" : 170, "y" : 451 } }, { "from" : { "x" : 170, "y" : 451 }, "to" : { "x" : 232, "y" : 477 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 236, "y" : 478 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 236, "y" : 478 } } } ] }, { "id" : 310, "reactomeId" : 179838, "displayName" : "PI(3,4,5)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 247, "y" : 574 }, "isFadeOut" : true, "minX" : 206, "maxX" : 288, "minY" : 503, "maxY" : 627, "prop" : { "x" : 206, "y" : 559, "width" : 82, "height" : 31 }, "textPosition" : { "x" : 208, "y" : 564 }, "connectors" : [ { "edgeId" : 336, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 246, "y" : 593 }, "to" : { "x" : 246, "y" : 627 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 307, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 247, "y" : 556 }, "to" : { "x" : 248, "y" : 503 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 243, "y" : 549 }, "b" : { "x" : 247, "y" : 556 }, "c" : { "x" : 251, "y" : 549 }, "type" : "ARROW", "centre" : { "x" : 251, "y" : 549 } } } ] }, { "id" : 311, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 346, "y" : 521 }, "isFadeOut" : true, "minX" : 248, "maxX" : 367, "minY" : 503, "maxY" : 537, "prop" : { "x" : 326, "y" : 506, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 330, "y" : 511 }, "connectors" : [ { "edgeId" : 307, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 323, "y" : 517 }, "to" : { "x" : 248, "y" : 503 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 315, "y" : 520 }, "b" : { "x" : 323, "y" : 517 }, "c" : { "x" : 317, "y" : 512 }, "type" : "ARROW", "centre" : { "x" : 317, "y" : 512 } } } ] }, { "id" : 13882, "reactomeId" : 9701478, "displayName" : "Active ALK:JAK3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 291, "y" : 1390 }, "isFadeOut" : true, "minX" : 241, "maxX" : 395, "minY" : 1379, "maxY" : 1516, "prop" : { "x" : 241, "y" : 1379, "width" : 101, "height" : 23 }, "textPosition" : { "x" : 241, "y" : 1381 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 13891, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 312, "y" : 1405 }, "to" : { "x" : 395, "y" : 1445 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 320, "y" : 1404 }, "b" : { "x" : 312, "y" : 1405 }, "c" : { "x" : 317, "y" : 1412 }, "type" : "ARROW", "centre" : { "x" : 317, "y" : 1412 } } }, { "edgeId" : 13881, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 292, "y" : 1405 }, "to" : { "x" : 300, "y" : 1493 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13881, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 285, "y" : 1405 }, "to" : { "x" : 248, "y" : 1479 } }, { "from" : { "x" : 248, "y" : 1479 }, "to" : { "x" : 286, "y" : 1510 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 289, "y" : 1512 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 289, "y" : 1512 } } }, { "edgeId" : 13886, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13883, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 352, "y" : 1452 }, "isFadeOut" : true, "minX" : 300, "maxX" : 372, "minY" : 1437, "maxY" : 1493, "prop" : { "x" : 332, "y" : 1437, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 336, "y" : 1442 }, "connectors" : [ { "edgeId" : 13881, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 329, "y" : 1467 }, "to" : { "x" : 300, "y" : 1493 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13884, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 346, "y" : 1559 }, "isFadeOut" : true, "minX" : 298, "maxX" : 367, "minY" : 1544, "maxY" : 1575, "prop" : { "x" : 326, "y" : 1544, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 330, "y" : 1549 }, "connectors" : [ { "edgeId" : 13881, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 323, "y" : 1554 }, "to" : { "x" : 298, "y" : 1549 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 315, "y" : 1557 }, "b" : { "x" : 323, "y" : 1554 }, "c" : { "x" : 317, "y" : 1549 }, "type" : "ARROW", "centre" : { "x" : 317, "y" : 1549 } } } ] }, { "id" : 13885, "reactomeId" : 9701475, "displayName" : "Active ALK:p-Y980 JAK3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 301, "y" : 1620 }, "isFadeOut" : true, "minX" : 240, "maxX" : 391, "minY" : 1549, "maxY" : 1639, "prop" : { "x" : 240, "y" : 1602, "width" : 123, "height" : 37 }, "textPosition" : { "x" : 241, "y" : 1604 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 13891, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 334, "y" : 1599 }, "to" : { "x" : 391, "y" : 1571 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13881, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 300, "y" : 1599 }, "to" : { "x" : 298, "y" : 1549 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 296, "y" : 1592 }, "b" : { "x" : 300, "y" : 1599 }, "c" : { "x" : 304, "y" : 1592 }, "type" : "ARROW", "centre" : { "x" : 304, "y" : 1592 } } } ] }, { "id" : 13887, "reactomeId" : 451893, "displayName" : "JAK3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 625, "y" : 1312 }, "isFadeOut" : true, "minX" : 512, "maxX" : 644, "minY" : 1258, "maxY" : 1324, "prop" : { "x" : 607, "y" : 1301, "width" : 37, "height" : 23 }, "textPosition" : { "x" : 608, "y" : 1302 }, "connectors" : [ { "edgeId" : 13886, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 604, "y" : 1303 }, "to" : { "x" : 512, "y" : 1258 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 321, "reactomeId" : 1257604, "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 771, "y" : 572 }, "isFadeOut" : true, "minX" : 702, "maxX" : 840, "minY" : 541, "maxY" : 603, "prop" : { "x" : 702, "y" : 541, "width" : 138, "height" : 62 }, "textPosition" : { "x" : 704, "y" : 550 }, "connectors" : [ ] }, { "id" : 13892, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 429, "y" : 1604 }, "isFadeOut" : true, "minX" : 391, "maxX" : 451, "minY" : 1571, "maxY" : 1620, "prop" : { "x" : 408, "y" : 1589, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 412, "y" : 1594 }, "connectors" : [ { "edgeId" : 13891, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 411, "y" : 1586 }, "to" : { "x" : 391, "y" : 1571 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13894, "reactomeId" : 197938, "displayName" : "PTPN6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 462, "y" : 1488 }, "isFadeOut" : true, "minX" : 405, "maxX" : 486, "minY" : 1477, "maxY" : 1500, "prop" : { "x" : 438, "y" : 1477, "width" : 48, "height" : 23 }, "textPosition" : { "x" : 438, "y" : 1478 }, "connectors" : [ { "edgeId" : 13891, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 435, "y" : 1487 }, "to" : { "x" : 413, "y" : 1487 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 409, "y" : 1487 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 409, "y" : 1487 } } } ] }, { "id" : 13896, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 447, "y" : 1424 }, "isFadeOut" : true, "minX" : 395, "maxX" : 461, "minY" : 1409, "maxY" : 1445, "prop" : { "x" : 434, "y" : 1409, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 438, "y" : 1414 }, "connectors" : [ { "edgeId" : 13891, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 431, "y" : 1429 }, "to" : { "x" : 395, "y" : 1445 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 426, "y" : 1435 }, "b" : { "x" : 431, "y" : 1429 }, "c" : { "x" : 423, "y" : 1428 }, "type" : "ARROW", "centre" : { "x" : 423, "y" : 1428 } } } ] }, { "id" : 13898, "reactomeId" : 539044, "displayName" : "STAT3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 919, "y" : 1033 }, "isFadeOut" : true, "minX" : 896, "maxX" : 1105, "minY" : 990, "maxY" : 1045, "prop" : { "x" : 896, "y" : 1022, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 896, "y" : 1023 }, "connectors" : [ { "edgeId" : 13897, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 946, "y" : 1027 }, "to" : { "x" : 1105, "y" : 990 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 337, "reactomeId" : 167682, "displayName" : "PLCG1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 313, "y" : 640 }, "isFadeOut" : true, "minX" : 246, "maxX" : 337, "minY" : 627, "maxY" : 652, "prop" : { "x" : 290, "y" : 629, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 290, "y" : 630 }, "connectors" : [ { "edgeId" : 336, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 287, "y" : 635 }, "to" : { "x" : 246, "y" : 627 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 338, "reactomeId" : 9699982, "displayName" : "Active ALK:PLCG1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 237, "y" : 719 }, "isFadeOut" : true, "minX" : 182, "maxX" : 293, "minY" : 708, "maxY" : 955, "prop" : { "x" : 182, "y" : 708, "width" : 111, "height" : 23 }, "textPosition" : { "x" : 200, "y" : 696 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 336, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 339, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 238, "y" : 734 }, "to" : { "x" : 253, "y" : 897 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 339, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 233, "y" : 734 }, "to" : { "x" : 202, "y" : 832 } }, { "from" : { "x" : 202, "y" : 832 }, "to" : { "x" : 246, "y" : 947 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 248, "y" : 951 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 248, "y" : 951 } } } ] }, { "id" : 13907, "reactomeId" : 539048, "displayName" : "p-Y705,S727-STAT3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1066, "y" : 1180 }, "isFadeOut" : true, "minX" : 1018, "maxX" : 1114, "minY" : 1156, "maxY" : 1259, "prop" : { "x" : 1018, "y" : 1162, "width" : 96, "height" : 37 }, "innerProp" : { "x" : 1018, "y" : 1168, "width" : 96, "height" : 31 }, "textPosition" : { "x" : 1020, "y" : 1163 }, "nodeAttachments" : [ { "reactomeId" : 539016, "label" : "P", "description" : "O-phospho-L-serine at 727", "shape" : { "a" : { "x" : 1027, "y" : 1156 }, "b" : { "x" : 1039, "y" : 1168 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1033, "y" : 1162 } } }, { "reactomeId" : 539045, "label" : "P", "description" : "O4'-phospho-L-tyrosine at 705", "shape" : { "a" : { "x" : 1043, "y" : 1156 }, "b" : { "x" : 1055, "y" : 1168 }, "s" : "P", "type" : "BOX", "empty" : true, "centre" : { "x" : 1049, "y" : 1162 } } } ], "connectors" : [ { "edgeId" : 13897, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13977, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1058, "y" : 1247 }, "b" : { "x" : 1070, "y" : 1259 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1064, "y" : 1253 } } } } ] }, { "id" : 340, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 335, "y" : 837 }, "isFadeOut" : true, "minX" : 253, "maxX" : 355, "minY" : 822, "maxY" : 897, "prop" : { "x" : 315, "y" : 822, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 319, "y" : 827 }, "connectors" : [ { "edgeId" : 339, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 312, "y" : 851 }, "to" : { "x" : 253, "y" : 897 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 276, "y" : 868 }, "b" : { "x" : 288, "y" : 880 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 282, "y" : 874 } } } } ] }, { "id" : 341, "reactomeId" : 9699992, "displayName" : "Active ALK:p-4Y PLCG1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 257, "y" : 1122 }, "isFadeOut" : true, "minX" : 204, "maxX" : 310, "minY" : 1009, "maxY" : 1141, "prop" : { "x" : 204, "y" : 1104, "width" : 106, "height" : 37 }, "textPosition" : { "x" : 204, "y" : 1106 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 339, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 256, "y" : 1101 }, "to" : { "x" : 255, "y" : 1009 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 252, "y" : 1094 }, "b" : { "x" : 256, "y" : 1101 }, "c" : { "x" : 260, "y" : 1094 }, "type" : "ARROW", "centre" : { "x" : 260, "y" : 1094 } } } ] }, { "id" : 348, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 368, "y" : 1013 }, "isFadeOut" : true, "minX" : 255, "maxX" : 389, "minY" : 998, "maxY" : 1029, "prop" : { "x" : 348, "y" : 998, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 352, "y" : 1003 }, "connectors" : [ { "edgeId" : 339, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 345, "y" : 1012 }, "to" : { "x" : 255, "y" : 1009 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 294, "y" : 1004 }, "b" : { "x" : 306, "y" : 1016 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 300, "y" : 1010 } } }, "endShape" : { "a" : { "x" : 338, "y" : 1016 }, "b" : { "x" : 345, "y" : 1012 }, "c" : { "x" : 338, "y" : 1008 }, "type" : "ARROW", "centre" : { "x" : 338, "y" : 1008 } } } ] }, { "id" : 92, "reactomeId" : 9700086, "displayName" : "(PTN,MDK):ALK dimer", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 318, "y" : 2209 }, "isFadeOut" : true, "minX" : 267, "maxX" : 369, "minY" : 2191, "maxY" : 2312, "prop" : { "x" : 267, "y" : 2191, "width" : 102, "height" : 37 }, "textPosition" : { "x" : 267, "y" : 2192 }, "connectors" : [ { "edgeId" : 106, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 315, "y" : 2234 }, "to" : { "x" : 306, "y" : 2312 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 318, "y" : 2241 }, "b" : { "x" : 315, "y" : 2234 }, "c" : { "x" : 310, "y" : 2240 }, "type" : "ARROW", "centre" : { "x" : 310, "y" : 2240 } } } ] }, { "id" : 96, "reactomeId" : 9700013, "displayName" : "(PTN,MDK):p-7Y ALK dimer", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 323, "y" : 2458 }, "isFadeOut" : true, "minX" : 268, "maxX" : 378, "minY" : 2370, "maxY" : 2477, "prop" : { "x" : 268, "y" : 2440, "width" : 110, "height" : 37 }, "textPosition" : { "x" : 269, "y" : 2441 }, "connectors" : [ { "edgeId" : 106, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 320, "y" : 2434 }, "to" : { "x" : 309, "y" : 2370 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 352, "reactomeId" : 1489509, "displayName" : "DAG and IP3 signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 443, "y" : 1166 }, "isFadeOut" : true, "minX" : 387, "maxX" : 500, "minY" : 1139, "maxY" : 1194, "prop" : { "x" : 387, "y" : 1139, "width" : 113, "height" : 55 }, "textPosition" : { "x" : 395, "y" : 1145 }, "connectors" : [ ] }, { "id" : 356, "reactomeId" : 354153, "displayName" : "SRC-1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1287, "y" : 525 }, "isFadeOut" : true, "minX" : 1264, "maxX" : 1329, "minY" : 514, "maxY" : 537, "prop" : { "x" : 1264, "y" : 514, "width" : 46, "height" : 23 }, "textPosition" : { "x" : 1265, "y" : 515 }, "connectors" : [ { "edgeId" : 355, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1313, "y" : 527 }, "to" : { "x" : 1329, "y" : 530 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 357, "reactomeId" : 9700422, "displayName" : "Active ALK:SRC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2126, "y" : 562 }, "isFadeOut" : true, "minX" : 2077, "maxX" : 2174, "minY" : 551, "maxY" : 642, "prop" : { "x" : 2079, "y" : 551, "width" : 95, "height" : 23 }, "textPosition" : { "x" : 2089, "y" : 539 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 355, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 358, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2128, "y" : 577 }, "to" : { "x" : 2140, "y" : 617 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 358, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2112, "y" : 577 }, "to" : { "x" : 2077, "y" : 605 } }, { "from" : { "x" : 2077, "y" : 605 }, "to" : { "x" : 2128, "y" : 636 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2132, "y" : 638 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2132, "y" : 638 } } } ] }, { "id" : 359, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2188, "y" : 601 }, "isFadeOut" : true, "minX" : 2140, "maxX" : 2208, "minY" : 586, "maxY" : 617, "prop" : { "x" : 2168, "y" : 586, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 2172, "y" : 591 }, "connectors" : [ { "edgeId" : 358, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2165, "y" : 607 }, "to" : { "x" : 2140, "y" : 617 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 360, "reactomeId" : 9700608, "displayName" : "Active ALK:p-Y419 SRC", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2148, "y" : 774 }, "isFadeOut" : true, "minX" : 2087, "maxX" : 2210, "minY" : 674, "maxY" : 793, "prop" : { "x" : 2087, "y" : 756, "width" : 123, "height" : 37 }, "textPosition" : { "x" : 2088, "y" : 758 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 358, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2147, "y" : 753 }, "to" : { "x" : 2143, "y" : 674 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2143, "y" : 746 }, "b" : { "x" : 2147, "y" : 753 }, "c" : { "x" : 2151, "y" : 746 }, "type" : "ARROW", "centre" : { "x" : 2151, "y" : 746 } } } ] }, { "id" : 361, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2194, "y" : 690 }, "isFadeOut" : true, "minX" : 2143, "maxX" : 2215, "minY" : 674, "maxY" : 706, "prop" : { "x" : 2174, "y" : 675, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 2178, "y" : 680 }, "connectors" : [ { "edgeId" : 358, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2171, "y" : 683 }, "to" : { "x" : 2143, "y" : 674 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2163, "y" : 685 }, "b" : { "x" : 2171, "y" : 683 }, "c" : { "x" : 2166, "y" : 677 }, "type" : "ARROW", "centre" : { "x" : 2166, "y" : 677 } } } ] }, { "id" : 107, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 424, "y" : 2402 }, "isFadeOut" : true, "minX" : 309, "maxX" : 446, "minY" : 2370, "maxY" : 2418, "prop" : { "x" : 403, "y" : 2387, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 407, "y" : 2392 }, "connectors" : [ { "edgeId" : 106, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 400, "y" : 2396 }, "to" : { "x" : 309, "y" : 2370 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 348, "y" : 2377 }, "b" : { "x" : 360, "y" : 2389 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 354, "y" : 2383 } } } } ] }, { "id" : 108, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 373, "y" : 2255 }, "isFadeOut" : true, "minX" : 306, "maxX" : 387, "minY" : 2240, "maxY" : 2312, "prop" : { "x" : 360, "y" : 2240, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 364, "y" : 2245 }, "connectors" : [ { "edgeId" : 106, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 357, "y" : 2266 }, "to" : { "x" : 306, "y" : 2312 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 325, "y" : 2283 }, "b" : { "x" : 337, "y" : 2295 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 331, "y" : 2289 } } }, "endShape" : { "a" : { "x" : 355, "y" : 2274 }, "b" : { "x" : 357, "y" : 2266 }, "c" : { "x" : 349, "y" : 2268 }, "type" : "ARROW", "centre" : { "x" : 349, "y" : 2268 } } } ] }, { "id" : 109, "reactomeId" : 9699799, "displayName" : "C4S-PTPRZ1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 207, "y" : 2209 }, "isFadeOut" : true, "minX" : 113, "maxX" : 302, "minY" : 2188, "maxY" : 2346, "prop" : { "x" : 162, "y" : 2193, "width" : 90, "height" : 32 }, "innerProp" : { "x" : 168, "y" : 2193, "width" : 84, "height" : 26 }, "textPosition" : { "x" : 165, "y" : 2198 }, "nodeAttachments" : [ { "reactomeId" : 9699893, "label" : "G", "description" : "O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at 637", "shape" : { "a" : { "x" : 156, "y" : 2188 }, "b" : { "x" : 168, "y" : 2200 }, "s" : "G", "type" : "BOX", "empty" : true, "centre" : { "x" : 162, "y" : 2194 } } }, { "reactomeId" : 9699823, "label" : "G", "description" : "O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at 1549", "shape" : { "a" : { "x" : 157, "y" : 2204 }, "b" : { "x" : 169, "y" : 2216 }, "s" : "G", "type" : "BOX", "empty" : true, "centre" : { "x" : 163, "y" : 2210 } } }, { "reactomeId" : 9699898, "label" : "G", "description" : "O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at 1551", "shape" : { "a" : { "x" : 181, "y" : 2219 }, "b" : { "x" : 193, "y" : 2231 }, "s" : "G", "type" : "BOX", "empty" : true, "centre" : { "x" : 187, "y" : 2225 } } }, { "reactomeId" : 9699857, "label" : "G", "description" : "O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at 997", "shape" : { "a" : { "x" : 166, "y" : 2219 }, "b" : { "x" : 178, "y" : 2231 }, "s" : "G", "type" : "BOX", "empty" : true, "centre" : { "x" : 172, "y" : 2225 } } } ], "connectors" : [ { "edgeId" : 15621, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 159, "y" : 2220 }, "to" : { "x" : 113, "y" : 2234 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 106, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 217, "y" : 2228 }, "to" : { "x" : 296, "y" : 2339 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 298, "y" : 2342 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 298, "y" : 2342 } } } ] }, { "id" : 114, "reactomeId" : 9700012, "displayName" : "(PTN,MDK):PTPRZ", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 204, "y" : 2318 }, "isFadeOut" : true, "minX" : 148, "maxX" : 261, "minY" : 2307, "maxY" : 2359, "prop" : { "x" : 148, "y" : 2307, "width" : 113, "height" : 23 }, "textPosition" : { "x" : 166, "y" : 2295 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 15621, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 115, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 191, "y" : 2347 }, "b" : { "x" : 203, "y" : 2359 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 197, "y" : 2353 } } } } ] }, { "id" : 116, "reactomeId" : 9700009, "displayName" : "(PTN,MDK):PTPRZ oligomers", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 210, "y" : 2425 }, "isFadeOut" : true, "minX" : 152, "maxX" : 300, "minY" : 2354, "maxY" : 2444, "prop" : { "x" : 152, "y" : 2407, "width" : 117, "height" : 37 }, "textPosition" : { "x" : 151, "y" : 2409 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 106, "type" : "INHIBITOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 234, "y" : 2404 }, "to" : { "x" : 298, "y" : 2357 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 296, "y" : 2354 }, "b" : { "x" : 300, "y" : 2360 }, "c" : { "x" : 298, "y" : 2357 }, "type" : "STOP", "centre" : { "x" : 298, "y" : 2357 } } }, { "edgeId" : 115, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 201595, "reactomeId" : 9700568, "displayName" : "NVP-TAE684-resistant ALK mutants", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 529, "y" : 286 }, "isDisease" : true, "minX" : 469, "maxX" : 613, "minY" : 149, "maxY" : 305, "prop" : { "x" : 469, "y" : 268, "width" : 121, "height" : 37 }, "textPosition" : { "x" : 483, "y" : 262 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "needDashedBorder" : true, "connectors" : [ { "edgeId" : 201594, "type" : "INPUT", "segments" : [ { "from" : { "x" : 540, "y" : 262 }, "to" : { "x" : 613, "y" : 149 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 16761, "reactomeId" : 6806003, "displayName" : "Regulation of TP53 Expression and Degradation", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 743, "y" : 3005 }, "isFadeOut" : true, "minX" : 661, "maxX" : 826, "minY" : 2971, "maxY" : 3040, "prop" : { "x" : 661, "y" : 2971, "width" : 165, "height" : 69 }, "textPosition" : { "x" : 674, "y" : 2977 }, "connectors" : [ ] }, { "id" : 201596, "reactomeId" : 9699607, "displayName" : "NVP-TAE684", "schemaClass" : "ChemicalDrug", "renderableClass" : "ChemicalDrug", "position" : { "x" : 718, "y" : 202 }, "isDisease" : true, "minX" : 613, "maxX" : 777, "minY" : 149, "maxY" : 221, "prop" : { "x" : 659, "y" : 184, "width" : 118, "height" : 37 }, "textPosition" : { "x" : 676, "y" : 192 }, "connectors" : [ { "edgeId" : 201594, "type" : "INPUT", "segments" : [ { "from" : { "x" : 681, "y" : 181 }, "to" : { "x" : 613, "y" : 149 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 14466, "reactomeId" : 179856, "displayName" : "PI(4,5)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 253, "y" : 388 }, "isFadeOut" : true, "minX" : 218, "maxX" : 288, "minY" : 373, "maxY" : 449, "prop" : { "x" : 218, "y" : 373, "width" : 70, "height" : 31 }, "textPosition" : { "x" : 220, "y" : 378 }, "connectors" : [ { "edgeId" : 307, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 250, "y" : 407 }, "to" : { "x" : 243, "y" : 449 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14467, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 375, "y" : 401 }, "isFadeOut" : true, "minX" : 243, "maxX" : 395, "minY" : 386, "maxY" : 449, "prop" : { "x" : 355, "y" : 386, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 359, "y" : 391 }, "connectors" : [ { "edgeId" : 307, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 352, "y" : 408 }, "to" : { "x" : 243, "y" : 449 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 16005, "reactomeId" : 1257604, "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2839, "y" : 2834 }, "isFadeOut" : true, "minX" : 2770, "maxX" : 2908, "minY" : 2804, "maxY" : 2864, "prop" : { "x" : 2770, "y" : 2804, "width" : 138, "height" : 60 }, "textPosition" : { "x" : 2772, "y" : 2812 }, "connectors" : [ ] }, { "id" : 15511, "reactomeId" : 9842597, "displayName" : "ALKAL2:(ALKAL1)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 206, "y" : 11 }, "isFadeOut" : true, "minX" : 152, "maxX" : 261, "minY" : 0, "maxY" : 116, "prop" : { "x" : 152, "y" : 0, "width" : 109, "height" : 23 }, "textPosition" : { "x" : 152, "y" : 1 }, "connectors" : [ { "edgeId" : 15513, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 210, "y" : 29 }, "to" : { "x" : 245, "y" : 116 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 15512, "reactomeId" : 9842608, "displayName" : "ALK dimer:ALKAL2:(ALKAL1)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 483, "y" : 160 }, "isFadeOut" : true, "minX" : 423, "maxX" : 544, "minY" : 142, "maxY" : 179, "prop" : { "x" : 423, "y" : 142, "width" : 121, "height" : 37 }, "textPosition" : { "x" : 424, "y" : 144 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 15513, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13978, "reactomeId" : 9701454, "displayName" : "p-Y705,S727-STAT3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1070, "y" : 1505 }, "isFadeOut" : true, "minX" : 1022, "maxX" : 1118, "minY" : 1487, "maxY" : 1524, "prop" : { "x" : 1022, "y" : 1487, "width" : 96, "height" : 37 }, "textPosition" : { "x" : 1024, "y" : 1489 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 13977, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13979, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13980, "reactomeId" : 9701457, "displayName" : "p-Y705,S727-STAT3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1634, "y" : 1483 }, "isFadeOut" : true, "minX" : 1460, "maxX" : 2031, "minY" : 1175, "maxY" : 1506, "prop" : { "x" : 1586, "y" : 1465, "width" : 96, "height" : 37 }, "textPosition" : { "x" : 1588, "y" : 1467 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 14088, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1685, "y" : 1491 }, "to" : { "x" : 1761, "y" : 1506 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14089, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1681, "y" : 1462 }, "to" : { "x" : 1787, "y" : 1424 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1686, "y" : 1456 }, "b" : { "x" : 1681, "y" : 1462 }, "c" : { "x" : 1689, "y" : 1463 }, "type" : "ARROW", "centre" : { "x" : 1689, "y" : 1463 } } }, { "edgeId" : 14095, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1604, "y" : 1462 }, "to" : { "x" : 1460, "y" : 1375 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14097, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1644, "y" : 1462 }, "to" : { "x" : 1807, "y" : 1175 } }, { "from" : { "x" : 1807, "y" : 1175 }, "to" : { "x" : 2031, "y" : 1177 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13979, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 413, "reactomeId" : 9700592, "displayName" : "ALK dimer:ligand:type I ALK binding TKI", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 901, "y" : 142 }, "isDisease" : true, "isFadeOut" : true, "minX" : 842, "maxX" : 960, "minY" : 117, "maxY" : 195, "prop" : { "x" : 842, "y" : 117, "width" : 118, "height" : 51 }, "textPosition" : { "x" : 841, "y" : 119 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "isCrossed" : true, "connectors" : [ { "edgeId" : 103, "type" : "INHIBITOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 895, "y" : 171 }, "to" : { "x" : 889, "y" : 194 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 885, "y" : 193 }, "b" : { "x" : 893, "y" : 195 }, "c" : { "x" : 889, "y" : 194 }, "type" : "STOP", "centre" : { "x" : 889, "y" : 194 } } }, { "edgeId" : 15480, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 201594, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 15519, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 789, "y" : 251 }, "isFadeOut" : true, "minX" : 769, "maxX" : 816, "minY" : 204, "maxY" : 267, "prop" : { "x" : 769, "y" : 236, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 773, "y" : 241 }, "connectors" : [ { "edgeId" : 103, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 797, "y" : 233 }, "to" : { "x" : 816, "y" : 204 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 800, "y" : 212 }, "b" : { "x" : 812, "y" : 224 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 806, "y" : 218 } } } } ] }, { "id" : 15520, "reactomeId" : 9850908, "displayName" : "ligand-bound ALK dimer", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 718, "y" : 202 }, "isFadeOut" : true, "minX" : 613, "maxX" : 880, "minY" : 149, "maxY" : 221, "prop" : { "x" : 659, "y" : 184, "width" : 118, "height" : 37 }, "textPosition" : { "x" : 659, "y" : 185 }, "connectors" : [ { "edgeId" : 103, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 783, "y" : 203 }, "to" : { "x" : 816, "y" : 204 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 103, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 774, "y" : 178 }, "to" : { "x" : 821, "y" : 168 } }, { "from" : { "x" : 821, "y" : 168 }, "to" : { "x" : 873, "y" : 196 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 876, "y" : 197 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 876, "y" : 197 } } }, { "edgeId" : 15480, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 681, "y" : 178 }, "to" : { "x" : 613, "y" : 149 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 416, "reactomeId" : 9699973, "displayName" : "type I ALK-binding TKIs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 529, "y" : 286 }, "isDisease" : true, "isFadeOut" : true, "minX" : 469, "maxX" : 613, "minY" : 149, "maxY" : 305, "prop" : { "x" : 469, "y" : 268, "width" : 121, "height" : 37 }, "textPosition" : { "x" : 469, "y" : 269 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 15480, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 540, "y" : 262 }, "to" : { "x" : 613, "y" : 149 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 16813, "reactomeId" : 453279, "displayName" : "Mitotic G1 phase and G1/S transition", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1458, "y" : 2239 }, "isFadeOut" : true, "minX" : 1375, "maxX" : 1541, "minY" : 2208, "maxY" : 2271, "prop" : { "x" : 1375, "y" : 2208, "width" : 166, "height" : 63 }, "textPosition" : { "x" : 1381, "y" : 2218 }, "connectors" : [ ] }, { "id" : 15790, "reactomeId" : 6783783, "displayName" : "Interleukin-10 signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1532, "y" : 3372 }, "isFadeOut" : true, "minX" : 1470, "maxX" : 1595, "minY" : 3346, "maxY" : 3399, "prop" : { "x" : 1470, "y" : 3346, "width" : 125, "height" : 53 }, "textPosition" : { "x" : 1479, "y" : 3351 }, "connectors" : [ ] }, { "id" : 175, "reactomeId" : 74769, "displayName" : "IRS1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1409, "y" : 333 }, "isFadeOut" : true, "minX" : 1392, "maxX" : 1448, "minY" : 298, "maxY" : 345, "prop" : { "x" : 1392, "y" : 322, "width" : 34, "height" : 23 }, "textPosition" : { "x" : 1395, "y" : 316 }, "connectors" : [ { "edgeId" : 174, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1421, "y" : 319 }, "to" : { "x" : 1448, "y" : 298 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 176, "reactomeId" : 9699993, "displayName" : "Active ALK:IRS1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1491, "y" : 240 }, "isFadeOut" : true, "minX" : 1442, "maxX" : 1579, "minY" : 215, "maxY" : 255, "prop" : { "x" : 1442, "y" : 229, "width" : 98, "height" : 23 }, "textPosition" : { "x" : 1454, "y" : 217 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 174, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 177, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1543, "y" : 250 }, "to" : { "x" : 1559, "y" : 255 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 177, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1529, "y" : 226 }, "to" : { "x" : 1574, "y" : 215 } }, { "from" : { "x" : 1574, "y" : 215 }, "to" : { "x" : 1575, "y" : 230 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1575, "y" : 234 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1575, "y" : 234 } } } ] }, { "id" : 178, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1592, "y" : 295 }, "isFadeOut" : true, "minX" : 1559, "maxX" : 1640, "minY" : 190, "maxY" : 311, "prop" : { "x" : 1572, "y" : 280, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1576, "y" : 285 }, "connectors" : [ { "edgeId" : 226, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1599, "y" : 277 }, "to" : { "x" : 1640, "y" : 190 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 1613, "y" : 227 }, "b" : { "x" : 1625, "y" : 239 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1619, "y" : 233 } } } }, { "edgeId" : 177, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1579, "y" : 277 }, "to" : { "x" : 1559, "y" : 255 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 179, "reactomeId" : 9699983, "displayName" : "Active ALK:pY-IRS1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1773, "y" : 245 }, "isFadeOut" : true, "minX" : 1656, "maxX" : 1833, "minY" : 234, "maxY" : 257, "prop" : { "x" : 1713, "y" : 234, "width" : 120, "height" : 23 }, "textPosition" : { "x" : 1713, "y" : 236 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 177, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1710, "y" : 245 }, "to" : { "x" : 1656, "y" : 246 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1703, "y" : 249 }, "b" : { "x" : 1710, "y" : 245 }, "c" : { "x" : 1703, "y" : 241 }, "type" : "ARROW", "centre" : { "x" : 1703, "y" : 241 } } } ] }, { "id" : 180, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1687, "y" : 295 }, "isFadeOut" : true, "minX" : 1656, "maxX" : 1708, "minY" : 191, "maxY" : 311, "prop" : { "x" : 1667, "y" : 280, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1671, "y" : 285 }, "connectors" : [ { "edgeId" : 226, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1688, "y" : 277 }, "to" : { "x" : 1695, "y" : 191 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 1685, "y" : 228 }, "b" : { "x" : 1697, "y" : 240 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1691, "y" : 234 } } }, "endShape" : { "a" : { "x" : 1685, "y" : 270 }, "b" : { "x" : 1688, "y" : 277 }, "c" : { "x" : 1693, "y" : 270 }, "type" : "ARROW", "centre" : { "x" : 1693, "y" : 270 } } }, { "edgeId" : 177, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1677, "y" : 277 }, "to" : { "x" : 1656, "y" : 246 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1670, "y" : 274 }, "b" : { "x" : 1677, "y" : 277 }, "c" : { "x" : 1676, "y" : 269 }, "type" : "ARROW", "centre" : { "x" : 1676, "y" : 269 } } } ] }, { "id" : 15284, "reactomeId" : 9725096, "displayName" : "ALK gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1246, "y" : 1414 }, "isFadeOut" : true, "minX" : 1215, "maxX" : 1326, "minY" : 1386, "maxY" : 1440, "prop" : { "x" : 1215, "y" : 1388, "width" : 63, "height" : 52 }, "textPosition" : { "x" : 1226, "y" : 1415 }, "connectors" : [ { "edgeId" : 15325, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1287, "y" : 1390 }, "to" : { "x" : 1326, "y" : 1390 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15283, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1285, "y" : 1386 }, "b" : { "x" : 1278, "y" : 1390 }, "c" : { "x" : 1285, "y" : 1394 }, "type" : "ARROW", "centre" : { "x" : 1285, "y" : 1394 } } }, { "id" : 15285, "reactomeId" : 9725109, "displayName" : "MYC/MYCN:ALK gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1297, "y" : 1302 }, "isFadeOut" : true, "minX" : 1053, "maxX" : 1349, "minY" : 1284, "maxY" : 1361, "prop" : { "x" : 1245, "y" : 1284, "width" : 104, "height" : 37 }, "textPosition" : { "x" : 1247, "y" : 1286 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 15325, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15283, "type" : "ACTIVATOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1242, "y" : 1314 }, "to" : { "x" : 1053, "y" : 1359 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1059, "y" : 1354 }, "b" : { "x" : 1053, "y" : 1359 }, "c" : { "x" : 1061, "y" : 1361 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1061, "y" : 1361 } } } ] }, { "id" : 15541, "reactomeId" : 9850879, "displayName" : "Active ALK dimer", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1218, "y" : 192 }, "isFadeOut" : true, "minX" : 246, "maxX" : 1448, "minY" : 181, "maxY" : 1258, "prop" : { "x" : 1165, "y" : 181, "width" : 107, "height" : 23 }, "textPosition" : { "x" : 1181, "y" : 175 }, "connectors" : [ { "edgeId" : 13897, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1216, "y" : 210 }, "to" : { "x" : 1105, "y" : 990 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 336, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1192, "y" : 210 }, "to" : { "x" : 246, "y" : 627 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 220, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1278, "y" : 192 }, "to" : { "x" : 1401, "y" : 193 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15773, "type" : "ACTIVATOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1219, "y" : 210 }, "to" : { "x" : 1309, "y" : 1190 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1304, "y" : 1183 }, "b" : { "x" : 1309, "y" : 1190 }, "c" : { "x" : 1312, "y" : 1183 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1312, "y" : 1183 } } }, { "edgeId" : 355, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1221, "y" : 210 }, "to" : { "x" : 1329, "y" : 530 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 295, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1176, "y" : 210 }, "to" : { "x" : 712, "y" : 331 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 103, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1159, "y" : 193 }, "to" : { "x" : 917, "y" : 203 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1152, "y" : 197 }, "b" : { "x" : 1159, "y" : 193 }, "c" : { "x" : 1152, "y" : 189 }, "type" : "ARROW", "centre" : { "x" : 1152, "y" : 189 } } }, { "edgeId" : 174, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1232, "y" : 210 }, "to" : { "x" : 1353, "y" : 300 } }, { "from" : { "x" : 1353, "y" : 300 }, "to" : { "x" : 1448, "y" : 298 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 181, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1229, "y" : 210 }, "to" : { "x" : 1424, "y" : 398 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13886, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1215, "y" : 210 }, "to" : { "x" : 1112, "y" : 709 } }, { "from" : { "x" : 1112, "y" : 709 }, "to" : { "x" : 512, "y" : 1258 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 182, "reactomeId" : 1169480, "displayName" : "SHC1-2,SHC1-3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1360, "y" : 423 }, "isFadeOut" : true, "minX" : 1308, "maxX" : 1424, "minY" : 398, "maxY" : 435, "prop" : { "x" : 1308, "y" : 412, "width" : 105, "height" : 23 }, "textPosition" : { "x" : 1309, "y" : 413 }, "connectors" : [ { "edgeId" : 181, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1389, "y" : 406 }, "to" : { "x" : 1424, "y" : 398 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 183, "reactomeId" : 9699970, "displayName" : "Active ALK:SHC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1946, "y" : 213 }, "isFadeOut" : true, "minX" : 1894, "maxX" : 2057, "minY" : 174, "maxY" : 225, "prop" : { "x" : 1894, "y" : 202, "width" : 104, "height" : 23 }, "textPosition" : { "x" : 1909, "y" : 190 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 181, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 184, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2001, "y" : 214 }, "to" : { "x" : 2021, "y" : 215 } }, { "from" : { "x" : 2021, "y" : 215 }, "to" : { "x" : 2040, "y" : 216 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 184, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1962, "y" : 199 }, "to" : { "x" : 2003, "y" : 174 } }, { "from" : { "x" : 2003, "y" : 174 }, "to" : { "x" : 2050, "y" : 205 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2053, "y" : 207 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2053, "y" : 207 } } } ] }, { "id" : 15544, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 954, "y" : 243 }, "isFadeOut" : true, "minX" : 917, "maxX" : 975, "minY" : 203, "maxY" : 259, "prop" : { "x" : 934, "y" : 228, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 938, "y" : 233 }, "connectors" : [ { "edgeId" : 103, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 939, "y" : 225 }, "to" : { "x" : 917, "y" : 203 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 922, "y" : 208 }, "b" : { "x" : 934, "y" : 220 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 928, "y" : 214 } } }, "endShape" : { "a" : { "x" : 931, "y" : 223 }, "b" : { "x" : 939, "y" : 225 }, "c" : { "x" : 937, "y" : 217 }, "type" : "ARROW", "centre" : { "x" : 937, "y" : 217 } } } ] }, { "id" : 185, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2002, "y" : 259 }, "isFadeOut" : true, "minX" : 1982, "maxX" : 2040, "minY" : 216, "maxY" : 275, "prop" : { "x" : 1982, "y" : 244, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1986, "y" : 249 }, "connectors" : [ { "edgeId" : 184, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2015, "y" : 241 }, "to" : { "x" : 2040, "y" : 216 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 2021, "y" : 222 }, "b" : { "x" : 2033, "y" : 234 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2027, "y" : 228 } } } } ] }, { "id" : 186, "reactomeId" : 9700011, "displayName" : "Active ALK:p-3Y SHC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2198, "y" : 208 }, "isFadeOut" : true, "minX" : 2085, "maxX" : 2252, "minY" : 190, "maxY" : 227, "prop" : { "x" : 2145, "y" : 190, "width" : 107, "height" : 37 }, "textPosition" : { "x" : 2146, "y" : 192 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 184, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2142, "y" : 209 }, "to" : { "x" : 2085, "y" : 212 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2135, "y" : 213 }, "b" : { "x" : 2142, "y" : 209 }, "c" : { "x" : 2135, "y" : 205 }, "type" : "ARROW", "centre" : { "x" : 2135, "y" : 205 } } } ] }, { "id" : 187, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2123, "y" : 264 }, "isFadeOut" : true, "minX" : 2085, "maxX" : 2144, "minY" : 212, "maxY" : 280, "prop" : { "x" : 2103, "y" : 249, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 2107, "y" : 254 }, "connectors" : [ { "edgeId" : 184, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2111, "y" : 246 }, "to" : { "x" : 2085, "y" : 212 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 2092, "y" : 223 }, "b" : { "x" : 2104, "y" : 235 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2098, "y" : 229 } } }, "endShape" : { "a" : { "x" : 2104, "y" : 243 }, "b" : { "x" : 2111, "y" : 246 }, "c" : { "x" : 2110, "y" : 238 }, "type" : "ARROW", "centre" : { "x" : 2110, "y" : 238 } } } ] }, { "id" : 15550, "reactomeId" : 9725313, "displayName" : "MYCN gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1250, "y" : 1221 }, "isFadeOut" : true, "minX" : 1213, "maxX" : 1295, "minY" : 1193, "maxY" : 1247, "prop" : { "x" : 1213, "y" : 1195, "width" : 75, "height" : 52 }, "textPosition" : { "x" : 1227, "y" : 1222 }, "connectors" : [ { "edgeId" : 15773, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1295, "y" : 1193 }, "b" : { "x" : 1288, "y" : 1197 }, "c" : { "x" : 1295, "y" : 1201 }, "type" : "ARROW", "centre" : { "x" : 1295, "y" : 1201 } } }, { "id" : 15551, "reactomeId" : 452357, "displayName" : "MYCN", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1358, "y" : 1198 }, "isFadeOut" : true, "minX" : 1337, "maxX" : 1380, "minY" : 1187, "maxY" : 1210, "prop" : { "x" : 1337, "y" : 1187, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 1337, "y" : 1188 }, "connectors" : [ { "edgeId" : 15773, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14015, "reactomeId" : 9701465, "displayName" : "AcK685- p-Y705,S727-STAT3 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1956, "y" : 1473 }, "isFadeOut" : true, "minX" : 1854, "maxX" : 2267, "minY" : 1354, "maxY" : 1572, "prop" : { "x" : 1895, "y" : 1455, "width" : 122, "height" : 37 }, "textPosition" : { "x" : 1895, "y" : 1457 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 16003, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2008, "y" : 1495 }, "to" : { "x" : 2238, "y" : 1572 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14088, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1898, "y" : 1495 }, "to" : { "x" : 1854, "y" : 1506 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1892, "y" : 1501 }, "b" : { "x" : 1898, "y" : 1495 }, "c" : { "x" : 1890, "y" : 1493 }, "type" : "ARROW", "centre" : { "x" : 1890, "y" : 1493 } } }, { "edgeId" : 14089, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1923, "y" : 1452 }, "to" : { "x" : 1873, "y" : 1426 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14091, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1977, "y" : 1452 }, "to" : { "x" : 2096, "y" : 1354 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15998, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2020, "y" : 1464 }, "to" : { "x" : 2267, "y" : 1430 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 191, "reactomeId" : 5673001, "displayName" : "RAF/MAP kinase cascade", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2124, "y" : 369 }, "isFadeOut" : true, "minX" : 2062, "maxX" : 2187, "minY" : 340, "maxY" : 398, "prop" : { "x" : 2062, "y" : 340, "width" : 125, "height" : 58 }, "textPosition" : { "x" : 2065, "y" : 347 }, "connectors" : [ ] }, { "id" : 14016, "reactomeId" : 351657, "displayName" : "SIN3A", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2061, "y" : 1420 }, "isFadeOut" : true, "minX" : 2040, "maxX" : 2267, "minY" : 1354, "maxY" : 1432, "prop" : { "x" : 2040, "y" : 1409, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 2043, "y" : 1403 }, "connectors" : [ { "edgeId" : 14091, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2067, "y" : 1406 }, "to" : { "x" : 2096, "y" : 1354 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15998, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2086, "y" : 1421 }, "to" : { "x" : 2267, "y" : 1430 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14017, "reactomeId" : 6804192, "displayName" : "PRDM1 Gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1996, "y" : 1321 }, "isFadeOut" : true, "minX" : 1954, "maxX" : 2096, "minY" : 1293, "maxY" : 1354, "prop" : { "x" : 1954, "y" : 1295, "width" : 85, "height" : 52 }, "textPosition" : { "x" : 1969, "y" : 1322 }, "connectors" : [ { "edgeId" : 14091, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2048, "y" : 1297 }, "to" : { "x" : 2096, "y" : 1354 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14092, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 2046, "y" : 1293 }, "b" : { "x" : 2039, "y" : 1297 }, "c" : { "x" : 2046, "y" : 1301 }, "type" : "ARROW", "centre" : { "x" : 2046, "y" : 1301 } } }, { "id" : 14018, "reactomeId" : 9701467, "displayName" : "SIN3A:AcK685,p-Y705,p-S727 STAT3 dimer:PRDM1 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2255, "y" : 1382 }, "isFadeOut" : true, "minX" : 2188, "maxX" : 2323, "minY" : 1315, "maxY" : 1408, "prop" : { "x" : 2188, "y" : 1357, "width" : 135, "height" : 51 }, "textPosition" : { "x" : 2189, "y" : 1359 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 14091, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14092, "type" : "INHIBITOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2241, "y" : 1354 }, "to" : { "x" : 2220, "y" : 1317 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2217, "y" : 1319 }, "b" : { "x" : 2223, "y" : 1315 }, "c" : { "x" : 2220, "y" : 1317 }, "type" : "STOP", "centre" : { "x" : 2220, "y" : 1317 } } } ] }, { "id" : 14020, "reactomeId" : 6804199, "displayName" : "PRDM1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2343, "y" : 1318 }, "isFadeOut" : true, "minX" : 2318, "maxX" : 2369, "minY" : 1307, "maxY" : 1330, "prop" : { "x" : 2318, "y" : 1307, "width" : 51, "height" : 23 }, "textPosition" : { "x" : 2318, "y" : 1308 }, "connectors" : [ { "edgeId" : 14092, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14034, "reactomeId" : 113560, "displayName" : "Ac-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1754, "y" : 1536 }, "isFadeOut" : true, "minX" : 1724, "maxX" : 1785, "minY" : 1506, "maxY" : 1552, "prop" : { "x" : 1724, "y" : 1521, "width" : 61, "height" : 31 }, "textPosition" : { "x" : 1729, "y" : 1526 }, "connectors" : [ { "edgeId" : 14088, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1757, "y" : 1518 }, "to" : { "x" : 1761, "y" : 1506 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14035, "reactomeId" : 2485002, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1907, "y" : 1552 }, "isFadeOut" : true, "minX" : 1854, "maxX" : 1938, "minY" : 1506, "maxY" : 1568, "prop" : { "x" : 1876, "y" : 1537, "width" : 62, "height" : 31 }, "textPosition" : { "x" : 1880, "y" : 1542 }, "connectors" : [ { "edgeId" : 14088, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1889, "y" : 1534 }, "to" : { "x" : 1854, "y" : 1506 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1881, "y" : 1533 }, "b" : { "x" : 1889, "y" : 1534 }, "c" : { "x" : 1886, "y" : 1527 }, "type" : "ARROW", "centre" : { "x" : 1886, "y" : 1527 } } } ] }, { "id" : 14036, "reactomeId" : 381325, "displayName" : "EP300", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1821, "y" : 1471 }, "isFadeOut" : true, "minX" : 1798, "maxX" : 1845, "minY" : 1460, "maxY" : 1499, "prop" : { "x" : 1798, "y" : 1460, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 1801, "y" : 1454 }, "connectors" : [ { "edgeId" : 14088, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1820, "y" : 1486 }, "to" : { "x" : 1820, "y" : 1491 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1820, "y" : 1495 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1820, "y" : 1495 } } } ] }, { "id" : 221, "reactomeId" : 190244, "displayName" : "FRS2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1375, "y" : 267 }, "isFadeOut" : true, "minX" : 1357, "maxX" : 1401, "minY" : 193, "maxY" : 279, "prop" : { "x" : 1357, "y" : 256, "width" : 37, "height" : 23 }, "textPosition" : { "x" : 1360, "y" : 250 }, "connectors" : [ { "edgeId" : 220, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1379, "y" : 253 }, "to" : { "x" : 1401, "y" : 193 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 15838, "reactomeId" : 9850883, "displayName" : "DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2539, "y" : 1573 }, "isFadeOut" : true, "minX" : 2477, "maxX" : 2602, "minY" : 1502, "maxY" : 1599, "prop" : { "x" : 2477, "y" : 1548, "width" : 125, "height" : 51 }, "textPosition" : { "x" : 2477, "y" : 1550 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 16003, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14094, "type" : "INHIBITOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2538, "y" : 1545 }, "to" : { "x" : 2538, "y" : 1502 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2534, "y" : 1502 }, "b" : { "x" : 2542, "y" : 1502 }, "c" : { "x" : 2538, "y" : 1502 }, "type" : "STOP", "centre" : { "x" : 2538, "y" : 1502 } } } ] }, { "id" : 222, "reactomeId" : 9700006, "displayName" : "Active ALK:FRS2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1501, "y" : 188 }, "isFadeOut" : true, "minX" : 1451, "maxX" : 1672, "minY" : 148, "maxY" : 200, "prop" : { "x" : 1451, "y" : 177, "width" : 101, "height" : 23 }, "textPosition" : { "x" : 1464, "y" : 165 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 220, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 226, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1555, "y" : 189 }, "to" : { "x" : 1600, "y" : 190 } }, { "from" : { "x" : 1600, "y" : 190 }, "to" : { "x" : 1640, "y" : 190 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 226, "type" : "CATALYST", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1540, "y" : 174 }, "to" : { "x" : 1640, "y" : 148 } }, { "from" : { "x" : 1640, "y" : 148 }, "to" : { "x" : 1666, "y" : 178 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1668, "y" : 181 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1668, "y" : 181 } } } ] }, { "id" : 15326, "reactomeId" : 3215043, "displayName" : "MYC,MYCN", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1392, "y" : 1394 }, "isFadeOut" : true, "minX" : 1326, "maxX" : 1428, "minY" : 1383, "maxY" : 1406, "prop" : { "x" : 1356, "y" : 1383, "width" : 72, "height" : 23 }, "textPosition" : { "x" : 1356, "y" : 1384 }, "connectors" : [ { "edgeId" : 15325, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1350, "y" : 1391 }, "to" : { "x" : 1326, "y" : 1390 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 15587, "reactomeId" : 201502, "displayName" : "ALK", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 189, "y" : 1907 }, "isFadeOut" : true, "minX" : 174, "maxX" : 277, "minY" : 1896, "maxY" : 2017, "prop" : { "x" : 174, "y" : 1896, "width" : 31, "height" : 23 }, "textPosition" : { "x" : 175, "y" : 1897 }, "connectors" : [ { "edgeId" : 27, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 208, "y" : 1918 }, "to" : { "x" : 277, "y" : 1972 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 29, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 190, "y" : 1922 }, "to" : { "x" : 206, "y" : 2017 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 228, "reactomeId" : 9700002, "displayName" : "Active ALK:p-6Y FRS2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1771, "y" : 184 }, "isFadeOut" : true, "minX" : 1695, "maxX" : 1825, "minY" : 166, "maxY" : 203, "prop" : { "x" : 1718, "y" : 166, "width" : 107, "height" : 37 }, "textPosition" : { "x" : 1719, "y" : 168 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 226, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1715, "y" : 188 }, "to" : { "x" : 1695, "y" : 191 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1709, "y" : 193 }, "b" : { "x" : 1715, "y" : 188 }, "c" : { "x" : 1708, "y" : 185 }, "type" : "ARROW", "centre" : { "x" : 1708, "y" : 185 } } } ] }, { "id" : 15844, "reactomeId" : 212181, "displayName" : "DNMT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2214, "y" : 1638 }, "isFadeOut" : true, "minX" : 2188, "maxX" : 2241, "minY" : 1572, "maxY" : 1650, "prop" : { "x" : 2188, "y" : 1627, "width" : 53, "height" : 23 }, "textPosition" : { "x" : 2189, "y" : 1628 }, "connectors" : [ { "edgeId" : 16003, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2218, "y" : 1624 }, "to" : { "x" : 2238, "y" : 1572 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14054, "reactomeId" : 427486, "displayName" : "CH3COO-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1737, "y" : 1384 }, "isFadeOut" : true, "minX" : 1700, "maxX" : 1787, "minY" : 1369, "maxY" : 1424, "prop" : { "x" : 1700, "y" : 1369, "width" : 75, "height" : 31 }, "textPosition" : { "x" : 1706, "y" : 1374 }, "connectors" : [ { "edgeId" : 14089, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 1756, "y" : 1403 }, "to" : { "x" : 1787, "y" : 1424 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1764, "y" : 1404 }, "b" : { "x" : 1756, "y" : 1403 }, "c" : { "x" : 1759, "y" : 1410 }, "type" : "ARROW", "centre" : { "x" : 1759, "y" : 1410 } } } ] }, { "id" : 14069, "reactomeId" : 9701417, "displayName" : "IL2RG gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 2144, "y" : 1492 }, "isFadeOut" : true, "minX" : 2107, "maxX" : 2267, "minY" : 1430, "maxY" : 1572, "prop" : { "x" : 2107, "y" : 1466, "width" : 75, "height" : 52 }, "textPosition" : { "x" : 2121, "y" : 1493 }, "connectors" : [ { "edgeId" : 16003, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2191, "y" : 1468 }, "to" : { "x" : 2238, "y" : 1572 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 14094, "type" : "INPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15998, "type" : "INPUT", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2191, "y" : 1468 }, "to" : { "x" : 2267, "y" : 1430 } } ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 2189, "y" : 1464 }, "b" : { "x" : 2182, "y" : 1468 }, "c" : { "x" : 2189, "y" : 1472 }, "type" : "ARROW", "centre" : { "x" : 2189, "y" : 1472 } } }, { "id" : 14070, "reactomeId" : 9701471, "displayName" : "SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2531, "y" : 1429 }, "isFadeOut" : true, "minX" : 2471, "maxX" : 2591, "minY" : 1404, "maxY" : 1485, "prop" : { "x" : 2471, "y" : 1404, "width" : 120, "height" : 51 }, "textPosition" : { "x" : 2471, "y" : 1406 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 14094, "type" : "INHIBITOR", "isFadeOut" : true, "segments" : [ { "from" : { "x" : 2533, "y" : 1458 }, "to" : { "x" : 2537, "y" : 1484 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2533, "y" : 1485 }, "b" : { "x" : 2541, "y" : 1483 }, "c" : { "x" : 2537, "y" : 1484 }, "type" : "STOP", "centre" : { "x" : 2537, "y" : 1484 } } }, { "edgeId" : 15998, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14078, "reactomeId" : 449139, "displayName" : "IL2RG", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2981, "y" : 1488 }, "isFadeOut" : true, "minX" : 2960, "maxX" : 3003, "minY" : 1477, "maxY" : 1500, "prop" : { "x" : 2960, "y" : 1477, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 2960, "y" : 1478 }, "connectors" : [ { "edgeId" : 14094, "type" : "OUTPUT", "isFadeOut" : true, "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 13891, "reactomeId" : 9701507, "displayName" : "PTPN6 dephosphorylates JAK3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 397, "y" : 1487 }, "isFadeOut" : true, "minX" : 391, "maxX" : 403, "minY" : 1445, "maxY" : 1571, "segments" : [ { "from" : { "x" : 391, "y" : 1571 }, "to" : { "x" : 397, "y" : 1487 } }, { "from" : { "x" : 397, "y" : 1487 }, "to" : { "x" : 395, "y" : 1445 } } ], "reactionShape" : { "a" : { "x" : 391, "y" : 1481 }, "b" : { "x" : 403, "y" : 1493 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 397, "y" : 1487 } }, "inputs" : [ { "id" : 13892, "points" : [ { "x" : 411, "y" : 1586 } ] }, { "id" : 13885, "points" : [ { "x" : 334, "y" : 1599 } ] } ], "outputs" : [ { "id" : 13882, "points" : [ { "x" : 312, "y" : 1405 } ] }, { "id" : 13896, "points" : [ { "x" : 431, "y" : 1429 } ] } ], "catalysts" : [ { "id" : 13894, "points" : [ { "x" : 435, "y" : 1487 } ] } ] }, { "id" : 16003, "reactomeId" : 9851058, "displayName" : "AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2300, "y" : 1569 }, "isFadeOut" : true, "minX" : 2238, "maxX" : 2474, "minY" : 1564, "maxY" : 1574, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 2238, "y" : 1572 }, "to" : { "x" : 2300, "y" : 1569 } }, { "from" : { "x" : 2300, "y" : 1569 }, "to" : { "x" : 2474, "y" : 1571 } } ], "endShape" : { "a" : { "x" : 2467, "y" : 1575 }, "b" : { "x" : 2474, "y" : 1571 }, "c" : { "x" : 2467, "y" : 1567 }, "type" : "ARROW", "centre" : { "x" : 2467, "y" : 1567 } }, "reactionShape" : { "c" : { "x" : 2300, "y" : 1569 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2300, "y" : 1569 } }, "inputs" : [ { "id" : 14069, "points" : [ { "x" : 2191, "y" : 1468 } ] }, { "id" : 14015, "points" : [ { "x" : 2008, "y" : 1495 } ] }, { "id" : 15844, "points" : [ { "x" : 2218, "y" : 1624 } ] } ], "outputs" : [ { "id" : 15838 } ] }, { "id" : 15621, "reactomeId" : 9700120, "displayName" : "PTN and MDK bind to PTPRZ", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 113, "y" : 2269 }, "isFadeOut" : true, "minX" : 108, "maxX" : 182, "minY" : 2234, "maxY" : 2304, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 113, "y" : 2234 }, "to" : { "x" : 113, "y" : 2269 } }, { "from" : { "x" : 113, "y" : 2269 }, "to" : { "x" : 182, "y" : 2304 } } ], "endShape" : { "a" : { "x" : 174, "y" : 2304 }, "b" : { "x" : 182, "y" : 2304 }, "c" : { "x" : 178, "y" : 2297 }, "type" : "ARROW", "centre" : { "x" : 178, "y" : 2297 } }, "reactionShape" : { "c" : { "x" : 113, "y" : 2269 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 113, "y" : 2269 } }, "inputs" : [ { "id" : 15622, "points" : [ { "x" : 118, "y" : 2008 } ] }, { "id" : 109, "points" : [ { "x" : 159, "y" : 2220 } ] } ], "outputs" : [ { "id" : 114 } ] }, { "id" : 7, "reactomeId" : 201486, "displayName" : "ALK binds ligand pleiotrophin (PTN)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 248, "y" : 1734 }, "isFadeOut" : true, "minX" : 227, "maxX" : 265, "minY" : 1715, "maxY" : 1765, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 227, "y" : 1715 }, "to" : { "x" : 248, "y" : 1734 } }, { "from" : { "x" : 248, "y" : 1734 }, "to" : { "x" : 265, "y" : 1765 } } ], "endShape" : { "a" : { "x" : 258, "y" : 1761 }, "b" : { "x" : 265, "y" : 1765 }, "c" : { "x" : 265, "y" : 1757 }, "type" : "ARROW", "centre" : { "x" : 265, "y" : 1757 } }, "reactionShape" : { "c" : { "x" : 248, "y" : 1734 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 248, "y" : 1734 } }, "inputs" : [ { "id" : 8, "points" : [ { "x" : 194, "y" : 1710 } ] }, { "id" : 9, "points" : [ { "x" : 147, "y" : 100 }, { "x" : 120, "y" : 462 } ] } ], "outputs" : [ { "id" : 10 } ] }, { "id" : 14088, "reactomeId" : 9701531, "displayName" : "p-Y705,S727 STAT3 is acetylated", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1820, "y" : 1507 }, "isFadeOut" : true, "minX" : 1761, "maxX" : 1854, "minY" : 1501, "maxY" : 1513, "segments" : [ { "from" : { "x" : 1761, "y" : 1506 }, "to" : { "x" : 1820, "y" : 1507 } }, { "from" : { "x" : 1820, "y" : 1507 }, "to" : { "x" : 1854, "y" : 1506 } } ], "reactionShape" : { "a" : { "x" : 1814, "y" : 1501 }, "b" : { "x" : 1826, "y" : 1513 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1820, "y" : 1507 } }, "inputs" : [ { "id" : 13980, "points" : [ { "x" : 1685, "y" : 1491 } ] }, { "id" : 14034, "points" : [ { "x" : 1757, "y" : 1518 } ] } ], "outputs" : [ { "id" : 14015, "points" : [ { "x" : 1898, "y" : 1495 } ] }, { "id" : 14035, "points" : [ { "x" : 1889, "y" : 1534 } ] } ], "catalysts" : [ { "id" : 14036, "points" : [ { "x" : 1820, "y" : 1486 } ] } ] }, { "id" : 13897, "reactomeId" : 9701524, "displayName" : "STAT3 is phosphorylated downstream of active ALK", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1070, "y" : 1120 }, "isFadeOut" : true, "minX" : 1064, "maxX" : 1105, "minY" : 990, "maxY" : 1159, "reactionType" : "Uncertain Process", "segments" : [ { "from" : { "x" : 1105, "y" : 990 }, "to" : { "x" : 1070, "y" : 1120 } }, { "from" : { "x" : 1070, "y" : 1120 }, "to" : { "x" : 1067, "y" : 1159 } } ], "endShape" : { "a" : { "x" : 1064, "y" : 1152 }, "b" : { "x" : 1067, "y" : 1159 }, "c" : { "x" : 1072, "y" : 1152 }, "type" : "ARROW", "centre" : { "x" : 1072, "y" : 1152 } }, "reactionShape" : { "a" : { "x" : 1064, "y" : 1114 }, "b" : { "x" : 1076, "y" : 1126 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 1070, "y" : 1120 } }, "inputs" : [ { "id" : 13898, "points" : [ { "x" : 946, "y" : 1027 } ] }, { "id" : 15541, "points" : [ { "x" : 1216, "y" : 210 } ] } ], "outputs" : [ { "id" : 13907 } ] }, { "id" : 14089, "reactomeId" : 9701565, "displayName" : "HDACs deacetylate p-STAT3 dimers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1835, "y" : 1424 }, "isFadeOut" : true, "minX" : 1787, "maxX" : 1873, "minY" : 1418, "maxY" : 1430, "segments" : [ { "from" : { "x" : 1873, "y" : 1426 }, "to" : { "x" : 1835, "y" : 1424 } }, { "from" : { "x" : 1835, "y" : 1424 }, "to" : { "x" : 1787, "y" : 1424 } } ], "reactionShape" : { "a" : { "x" : 1829, "y" : 1418 }, "b" : { "x" : 1841, "y" : 1430 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1835, "y" : 1424 } }, "inputs" : [ { "id" : 14015, "points" : [ { "x" : 1923, "y" : 1452 } ] }, { "id" : 14090, "points" : [ { "x" : 1900, "y" : 1395 } ] } ], "outputs" : [ { "id" : 14054, "points" : [ { "x" : 1756, "y" : 1403 } ] }, { "id" : 13980, "points" : [ { "x" : 1681, "y" : 1462 } ] } ], "catalysts" : [ { "id" : 14087, "points" : [ { "x" : 1832, "y" : 1359 } ] } ] }, { "id" : 11, "reactomeId" : 9667914, "displayName" : "ALK binds ligand midkine (MDK)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 165, "y" : 1782 }, "isFadeOut" : true, "minX" : 141, "maxX" : 199, "minY" : 1726, "maxY" : 1803, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 141, "y" : 1726 }, "to" : { "x" : 165, "y" : 1782 } }, { "from" : { "x" : 165, "y" : 1782 }, "to" : { "x" : 199, "y" : 1803 } } ], "endShape" : { "a" : { "x" : 191, "y" : 1803 }, "b" : { "x" : 199, "y" : 1803 }, "c" : { "x" : 195, "y" : 1796 }, "type" : "ARROW", "centre" : { "x" : 195, "y" : 1796 } }, "reactionShape" : { "c" : { "x" : 165, "y" : 1782 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 165, "y" : 1782 } }, "inputs" : [ { "id" : 12, "points" : [ { "x" : 125, "y" : 1716 } ] }, { "id" : 9, "points" : [ { "x" : 144, "y" : 100 }, { "x" : 76, "y" : 328 }, { "x" : 102, "y" : 1552 } ] } ], "outputs" : [ { "id" : 13 } ] }, { "id" : 14091, "reactomeId" : 9701549, "displayName" : "AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2145, "y" : 1376 }, "isFadeOut" : true, "minX" : 2096, "maxX" : 2185, "minY" : 1354, "maxY" : 1381, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 2096, "y" : 1354 }, "to" : { "x" : 2145, "y" : 1376 } }, { "from" : { "x" : 2145, "y" : 1376 }, "to" : { "x" : 2185, "y" : 1378 } } ], "endShape" : { "a" : { "x" : 2178, "y" : 1382 }, "b" : { "x" : 2185, "y" : 1378 }, "c" : { "x" : 2178, "y" : 1374 }, "type" : "ARROW", "centre" : { "x" : 2178, "y" : 1374 } }, "reactionShape" : { "c" : { "x" : 2145, "y" : 1376 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2145, "y" : 1376 } }, "inputs" : [ { "id" : 14015, "points" : [ { "x" : 1977, "y" : 1452 } ] }, { "id" : 14017, "points" : [ { "x" : 2048, "y" : 1297 } ] }, { "id" : 14016, "points" : [ { "x" : 2067, "y" : 1406 } ] } ], "outputs" : [ { "id" : 14018 } ] }, { "id" : 14092, "reactomeId" : 9701548, "displayName" : "PRDM1 gene expression downstream of ALK signaling", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2216, "y" : 1309 }, "isFadeOut" : true, "minX" : 2048, "maxX" : 2315, "minY" : 1297, "maxY" : 1316, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 2048, "y" : 1297 }, "to" : { "x" : 2216, "y" : 1309 } }, { "from" : { "x" : 2216, "y" : 1309 }, "to" : { "x" : 2315, "y" : 1316 } } ], "endShape" : { "a" : { "x" : 2308, "y" : 1320 }, "b" : { "x" : 2315, "y" : 1316 }, "c" : { "x" : 2308, "y" : 1312 }, "type" : "ARROW", "centre" : { "x" : 2308, "y" : 1312 } }, "reactionShape" : { "a" : { "x" : 2210, "y" : 1303 }, "b" : { "x" : 2222, "y" : 1315 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2216, "y" : 1309 } }, "inputs" : [ { "id" : 14017 } ], "outputs" : [ { "id" : 14020 } ], "inhibitors" : [ { "id" : 14018, "points" : [ { "x" : 2241, "y" : 1354 } ] } ] }, { "id" : 14094, "reactomeId" : 9701556, "displayName" : "IL2RG gene expression downstream of ALK signaling", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2538, "y" : 1493 }, "isFadeOut" : true, "minX" : 2191, "maxX" : 2957, "minY" : 1468, "maxY" : 1499, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 2191, "y" : 1468 }, "to" : { "x" : 2538, "y" : 1493 } }, { "from" : { "x" : 2538, "y" : 1493 }, "to" : { "x" : 2957, "y" : 1488 } } ], "endShape" : { "a" : { "x" : 2950, "y" : 1492 }, "b" : { "x" : 2957, "y" : 1488 }, "c" : { "x" : 2950, "y" : 1484 }, "type" : "ARROW", "centre" : { "x" : 2950, "y" : 1484 } }, "reactionShape" : { "a" : { "x" : 2532, "y" : 1487 }, "b" : { "x" : 2544, "y" : 1499 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2538, "y" : 1493 } }, "inputs" : [ { "id" : 14069 } ], "outputs" : [ { "id" : 14078 } ], "inhibitors" : [ { "id" : 14070, "points" : [ { "x" : 2533, "y" : 1458 } ] }, { "id" : 15838, "points" : [ { "x" : 2538, "y" : 1545 } ] } ] }, { "id" : 14095, "reactomeId" : 9701534, "displayName" : "p-Y705, S727 STAT3 dimer binds HIF1A gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1430, "y" : 1329 }, "isFadeOut" : true, "minX" : 1425, "maxX" : 1501, "minY" : 1195, "maxY" : 1375, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1460, "y" : 1375 }, "to" : { "x" : 1430, "y" : 1329 } }, { "from" : { "x" : 1430, "y" : 1329 }, "to" : { "x" : 1501, "y" : 1195 } } ], "endShape" : { "a" : { "x" : 1501, "y" : 1203 }, "b" : { "x" : 1501, "y" : 1195 }, "c" : { "x" : 1494, "y" : 1199 }, "type" : "ARROW", "centre" : { "x" : 1494, "y" : 1199 } }, "reactionShape" : { "c" : { "x" : 1430, "y" : 1329 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1430, "y" : 1329 } }, "inputs" : [ { "id" : 13980, "points" : [ { "x" : 1604, "y" : 1462 } ] }, { "id" : 14083, "points" : [ { "x" : 1599, "y" : 1299 }, { "x" : 1540, "y" : 1279 }, { "x" : 1492, "y" : 1282 } ] } ], "outputs" : [ { "id" : 14084 } ] }, { "id" : 14096, "reactomeId" : 9701569, "displayName" : "ALK- and STAT3-dependent HIF1A gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1630, "y" : 1311 }, "isFadeOut" : true, "minX" : 1599, "maxX" : 1656, "minY" : 1299, "maxY" : 1317, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 1599, "y" : 1299 }, "to" : { "x" : 1630, "y" : 1311 } }, { "from" : { "x" : 1630, "y" : 1311 }, "to" : { "x" : 1656, "y" : 1311 } } ], "endShape" : { "a" : { "x" : 1649, "y" : 1315 }, "b" : { "x" : 1656, "y" : 1311 }, "c" : { "x" : 1649, "y" : 1307 }, "type" : "ARROW", "centre" : { "x" : 1649, "y" : 1307 } }, "reactionShape" : { "a" : { "x" : 1624, "y" : 1305 }, "b" : { "x" : 1636, "y" : 1317 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1630, "y" : 1311 } }, "inputs" : [ { "id" : 14083 } ], "outputs" : [ { "id" : 14086 } ], "activators" : [ { "id" : 14084, "points" : [ { "x" : 1566, "y" : 1195 }, { "x" : 1621, "y" : 1219 } ] } ] }, { "id" : 336, "reactomeId" : 9700149, "displayName" : "Active ALK binds PLCG1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 240, "y" : 663 }, "isFadeOut" : true, "minX" : 235, "maxX" : 246, "minY" : 627, "maxY" : 705, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 246, "y" : 627 }, "to" : { "x" : 240, "y" : 663 } }, { "from" : { "x" : 240, "y" : 663 }, "to" : { "x" : 237, "y" : 705 } } ], "endShape" : { "a" : { "x" : 234, "y" : 698 }, "b" : { "x" : 237, "y" : 705 }, "c" : { "x" : 241, "y" : 698 }, "type" : "ARROW", "centre" : { "x" : 241, "y" : 698 } }, "reactionShape" : { "c" : { "x" : 240, "y" : 663 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 240, "y" : 663 } }, "inputs" : [ { "id" : 337, "points" : [ { "x" : 287, "y" : 635 } ] }, { "id" : 310, "points" : [ { "x" : 246, "y" : 593 } ] }, { "id" : 15541, "points" : [ { "x" : 1192, "y" : 210 } ] } ], "outputs" : [ { "id" : 338 } ] }, { "id" : 14097, "reactomeId" : 9701537, "displayName" : "p-Y705, S727 STAT3 dimer binds CD274 gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2102, "y" : 1177 }, "isFadeOut" : true, "minX" : 2031, "maxX" : 2152, "minY" : 1172, "maxY" : 1182, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 2031, "y" : 1177 }, "to" : { "x" : 2102, "y" : 1177 } }, { "from" : { "x" : 2102, "y" : 1177 }, "to" : { "x" : 2152, "y" : 1174 } } ], "endShape" : { "a" : { "x" : 2145, "y" : 1178 }, "b" : { "x" : 2152, "y" : 1174 }, "c" : { "x" : 2145, "y" : 1170 }, "type" : "ARROW", "centre" : { "x" : 2145, "y" : 1170 } }, "reactionShape" : { "c" : { "x" : 2102, "y" : 1177 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2102, "y" : 1177 } }, "inputs" : [ { "id" : 14098, "points" : [ { "x" : 1993, "y" : 1223 } ] }, { "id" : 13980, "points" : [ { "x" : 1644, "y" : 1462 }, { "x" : 1807, "y" : 1175 } ] } ], "outputs" : [ { "id" : 14099 } ] }, { "id" : 339, "reactomeId" : 9700171, "displayName" : "Active ALK phosphorylates PLCG1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 252, "y" : 962 }, "isFadeOut" : true, "minX" : 246, "maxX" : 258, "minY" : 897, "maxY" : 1009, "segments" : [ { "from" : { "x" : 253, "y" : 897 }, "to" : { "x" : 252, "y" : 962 } }, { "from" : { "x" : 252, "y" : 962 }, "to" : { "x" : 255, "y" : 1009 } } ], "reactionShape" : { "a" : { "x" : 246, "y" : 956 }, "b" : { "x" : 258, "y" : 968 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 252, "y" : 962 } }, "inputs" : [ { "id" : 340, "points" : [ { "x" : 312, "y" : 851 } ], "stoichiometry" : 4 }, { "id" : 338, "points" : [ { "x" : 238, "y" : 734 } ] } ], "outputs" : [ { "id" : 348, "points" : [ { "x" : 345, "y" : 1012 } ], "stoichiometry" : 4 }, { "id" : 341, "points" : [ { "x" : 256, "y" : 1101 } ] } ], "catalysts" : [ { "id" : 338, "points" : [ { "x" : 233, "y" : 734 }, { "x" : 202, "y" : 832 } ] } ] }, { "id" : 14100, "reactomeId" : 9701562, "displayName" : "CD274 gene expression downstream of ALK signaling", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2230, "y" : 1238 }, "isFadeOut" : true, "minX" : 1993, "maxX" : 2952, "minY" : 1223, "maxY" : 1244, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 1993, "y" : 1223 }, "to" : { "x" : 2230, "y" : 1238 } }, { "from" : { "x" : 2230, "y" : 1238 }, "to" : { "x" : 2952, "y" : 1240 } } ], "endShape" : { "a" : { "x" : 2945, "y" : 1244 }, "b" : { "x" : 2952, "y" : 1240 }, "c" : { "x" : 2945, "y" : 1236 }, "type" : "ARROW", "centre" : { "x" : 2945, "y" : 1236 } }, "reactionShape" : { "a" : { "x" : 2224, "y" : 1232 }, "b" : { "x" : 2236, "y" : 1244 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2230, "y" : 1238 } }, "inputs" : [ { "id" : 14098 } ], "outputs" : [ { "id" : 14101 } ], "activators" : [ { "id" : 14099, "points" : [ { "x" : 2225, "y" : 1201 } ] } ] }, { "id" : 13977, "reactomeId" : 9701525, "displayName" : "p-Y705,S727-STAT3 dimerizes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1064, "y" : 1304 }, "isFadeOut" : true, "minX" : 1059, "maxX" : 1069, "minY" : 1202, "maxY" : 1484, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1065, "y" : 1202 }, "to" : { "x" : 1064, "y" : 1304 } }, { "from" : { "x" : 1064, "y" : 1304 }, "to" : { "x" : 1069, "y" : 1484 } } ], "endShape" : { "a" : { "x" : 1065, "y" : 1477 }, "b" : { "x" : 1069, "y" : 1484 }, "c" : { "x" : 1073, "y" : 1477 }, "type" : "ARROW", "centre" : { "x" : 1073, "y" : 1477 } }, "reactionShape" : { "c" : { "x" : 1064, "y" : 1304 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1064, "y" : 1304 } }, "inputs" : [ { "id" : 13907, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 13978 } ] }, { "id" : 15513, "reactomeId" : 9842656, "displayName" : "ALK binds ALKAL ligand", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 324, "y" : 142 }, "isFadeOut" : true, "minX" : 245, "maxX" : 420, "minY" : 116, "maxY" : 153, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 245, "y" : 116 }, "to" : { "x" : 324, "y" : 142 } }, { "from" : { "x" : 324, "y" : 142 }, "to" : { "x" : 420, "y" : 153 } } ], "endShape" : { "a" : { "x" : 413, "y" : 156 }, "b" : { "x" : 420, "y" : 153 }, "c" : { "x" : 414, "y" : 148 }, "type" : "ARROW", "centre" : { "x" : 414, "y" : 148 } }, "reactionShape" : { "c" : { "x" : 324, "y" : 142 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 324, "y" : 142 } }, "inputs" : [ { "id" : 15511, "points" : [ { "x" : 210, "y" : 29 } ] }, { "id" : 9, "points" : [ { "x" : 167, "y" : 89 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 15512 } ] }, { "id" : 13979, "reactomeId" : 9701529, "displayName" : "p-Y705, p-S727 STAT3 dimer translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1393, "y" : 1500 }, "isFadeOut" : true, "minX" : 1121, "maxX" : 1583, "minY" : 1486, "maxY" : 1506, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 1121, "y" : 1504 }, "to" : { "x" : 1393, "y" : 1500 } }, { "from" : { "x" : 1393, "y" : 1500 }, "to" : { "x" : 1583, "y" : 1486 } } ], "endShape" : { "a" : { "x" : 1576, "y" : 1490 }, "b" : { "x" : 1583, "y" : 1486 }, "c" : { "x" : 1576, "y" : 1483 }, "type" : "ARROW", "centre" : { "x" : 1576, "y" : 1483 } }, "reactionShape" : { "a" : { "x" : 1387, "y" : 1494 }, "b" : { "x" : 1399, "y" : 1506 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1393, "y" : 1500 } }, "inputs" : [ { "id" : 13978 } ], "outputs" : [ { "id" : 13980 } ] }, { "id" : 27, "reactomeId" : 201519, "displayName" : "ALK:PTN dimerization", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 281, "y" : 1998 }, "isFadeOut" : true, "minX" : 276, "maxX" : 318, "minY" : 1972, "maxY" : 2072, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 277, "y" : 1972 }, "to" : { "x" : 281, "y" : 1998 } }, { "from" : { "x" : 281, "y" : 1998 }, "to" : { "x" : 318, "y" : 2072 } } ], "endShape" : { "a" : { "x" : 311, "y" : 2068 }, "b" : { "x" : 318, "y" : 2072 }, "c" : { "x" : 318, "y" : 2064 }, "type" : "ARROW", "centre" : { "x" : 318, "y" : 2064 } }, "reactionShape" : { "c" : { "x" : 281, "y" : 1998 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 281, "y" : 1998 } }, "inputs" : [ { "id" : 10, "points" : [ { "x" : 271, "y" : 1794 }, { "x" : 278, "y" : 1912 } ] }, { "id" : 15587, "points" : [ { "x" : 208, "y" : 1918 } ] } ], "outputs" : [ { "id" : 28 } ] }, { "id" : 220, "reactomeId" : 9700142, "displayName" : "Active ALK binds FRS2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1421, "y" : 193 }, "isFadeOut" : true, "minX" : 1401, "maxX" : 1448, "minY" : 188, "maxY" : 198, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1401, "y" : 193 }, "to" : { "x" : 1421, "y" : 193 } }, { "from" : { "x" : 1421, "y" : 193 }, "to" : { "x" : 1448, "y" : 191 } } ], "endShape" : { "a" : { "x" : 1441, "y" : 196 }, "b" : { "x" : 1448, "y" : 191 }, "c" : { "x" : 1441, "y" : 188 }, "type" : "ARROW", "centre" : { "x" : 1441, "y" : 188 } }, "reactionShape" : { "c" : { "x" : 1421, "y" : 193 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1421, "y" : 193 } }, "inputs" : [ { "id" : 15541, "points" : [ { "x" : 1278, "y" : 192 } ] }, { "id" : 221, "points" : [ { "x" : 1379, "y" : 253 } ] } ], "outputs" : [ { "id" : 222 } ] }, { "id" : 15325, "reactomeId" : 9725332, "displayName" : "MYC/MYCN bind the ALK gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1333, "y" : 1365 }, "isFadeOut" : true, "minX" : 1307, "maxX" : 1338, "minY" : 1324, "maxY" : 1390, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1326, "y" : 1390 }, "to" : { "x" : 1333, "y" : 1365 } }, { "from" : { "x" : 1333, "y" : 1365 }, "to" : { "x" : 1307, "y" : 1324 } } ], "endShape" : { "a" : { "x" : 1314, "y" : 1328 }, "b" : { "x" : 1307, "y" : 1324 }, "c" : { "x" : 1307, "y" : 1332 }, "type" : "ARROW", "centre" : { "x" : 1307, "y" : 1332 } }, "reactionShape" : { "c" : { "x" : 1333, "y" : 1365 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1333, "y" : 1365 } }, "inputs" : [ { "id" : 15284, "points" : [ { "x" : 1287, "y" : 1390 } ] }, { "id" : 15326, "points" : [ { "x" : 1350, "y" : 1391 } ] } ], "outputs" : [ { "id" : 15285 } ] }, { "id" : 15773, "reactomeId" : 9725315, "displayName" : "ALK-stimulated MYCN gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1310, "y" : 1199 }, "isFadeOut" : true, "minX" : 1297, "maxX" : 1334, "minY" : 1193, "maxY" : 1205, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 1297, "y" : 1197 }, "to" : { "x" : 1310, "y" : 1199 } }, { "from" : { "x" : 1310, "y" : 1199 }, "to" : { "x" : 1334, "y" : 1198 } } ], "endShape" : { "a" : { "x" : 1327, "y" : 1202 }, "b" : { "x" : 1334, "y" : 1198 }, "c" : { "x" : 1327, "y" : 1194 }, "type" : "ARROW", "centre" : { "x" : 1327, "y" : 1194 } }, "reactionShape" : { "a" : { "x" : 1304, "y" : 1193 }, "b" : { "x" : 1316, "y" : 1205 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1310, "y" : 1199 } }, "inputs" : [ { "id" : 15550 } ], "outputs" : [ { "id" : 15551 } ], "activators" : [ { "id" : 15541, "points" : [ { "x" : 1219, "y" : 210 } ] } ] }, { "id" : 29, "reactomeId" : 9700137, "displayName" : "ALK:MDK dimerization", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 208, "y" : 2052 }, "isFadeOut" : true, "minX" : 203, "maxX" : 222, "minY" : 2017, "maxY" : 2101, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 206, "y" : 2017 }, "to" : { "x" : 208, "y" : 2052 } }, { "from" : { "x" : 208, "y" : 2052 }, "to" : { "x" : 222, "y" : 2101 } } ], "endShape" : { "a" : { "x" : 216, "y" : 2095 }, "b" : { "x" : 222, "y" : 2101 }, "c" : { "x" : 224, "y" : 2093 }, "type" : "ARROW", "centre" : { "x" : 224, "y" : 2093 } }, "reactionShape" : { "c" : { "x" : 208, "y" : 2052 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 208, "y" : 2052 } }, "inputs" : [ { "id" : 13, "points" : [ { "x" : 208, "y" : 1832 }, { "x" : 144, "y" : 1929 } ] }, { "id" : 15587, "points" : [ { "x" : 190, "y" : 1922 } ] } ], "outputs" : [ { "id" : 30 } ] }, { "id" : 226, "reactomeId" : 9700164, "displayName" : "Active ALK phosphorylates FRS2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1676, "y" : 190 }, "isFadeOut" : true, "minX" : 1640, "maxX" : 1695, "minY" : 184, "maxY" : 196, "segments" : [ { "from" : { "x" : 1640, "y" : 190 }, "to" : { "x" : 1676, "y" : 190 } }, { "from" : { "x" : 1676, "y" : 190 }, "to" : { "x" : 1695, "y" : 191 } } ], "reactionShape" : { "a" : { "x" : 1670, "y" : 184 }, "b" : { "x" : 1682, "y" : 196 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1676, "y" : 190 } }, "inputs" : [ { "id" : 222, "points" : [ { "x" : 1555, "y" : 189 }, { "x" : 1600, "y" : 190 } ] }, { "id" : 178, "points" : [ { "x" : 1599, "y" : 277 } ], "stoichiometry" : 6 } ], "outputs" : [ { "id" : 228, "points" : [ { "x" : 1715, "y" : 188 } ] }, { "id" : 180, "points" : [ { "x" : 1688, "y" : 277 } ], "stoichiometry" : 6 } ], "catalysts" : [ { "id" : 222, "points" : [ { "x" : 1540, "y" : 174 }, { "x" : 1640, "y" : 148 } ] } ] }, { "id" : 355, "reactomeId" : 9700648, "displayName" : "Active ALK binds SRC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1422, "y" : 572 }, "isFadeOut" : true, "minX" : 1329, "maxX" : 2076, "minY" : 530, "maxY" : 577, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1329, "y" : 530 }, "to" : { "x" : 1422, "y" : 572 } }, { "from" : { "x" : 1422, "y" : 572 }, "to" : { "x" : 2076, "y" : 562 } } ], "endShape" : { "a" : { "x" : 2069, "y" : 566 }, "b" : { "x" : 2076, "y" : 562 }, "c" : { "x" : 2069, "y" : 558 }, "type" : "ARROW", "centre" : { "x" : 2069, "y" : 558 } }, "reactionShape" : { "c" : { "x" : 1422, "y" : 572 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1422, "y" : 572 } }, "inputs" : [ { "id" : 356, "points" : [ { "x" : 1313, "y" : 527 } ] }, { "id" : 15541, "points" : [ { "x" : 1221, "y" : 210 } ] } ], "outputs" : [ { "id" : 357 } ] }, { "id" : 358, "reactomeId" : 9700647, "displayName" : "Active ALK phosphorylates SRC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2142, "y" : 644 }, "isFadeOut" : true, "minX" : 2136, "maxX" : 2148, "minY" : 617, "maxY" : 674, "segments" : [ { "from" : { "x" : 2140, "y" : 617 }, "to" : { "x" : 2142, "y" : 644 } }, { "from" : { "x" : 2142, "y" : 644 }, "to" : { "x" : 2143, "y" : 674 } } ], "reactionShape" : { "a" : { "x" : 2136, "y" : 638 }, "b" : { "x" : 2148, "y" : 650 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2142, "y" : 644 } }, "inputs" : [ { "id" : 359, "points" : [ { "x" : 2165, "y" : 607 } ] }, { "id" : 357, "points" : [ { "x" : 2128, "y" : 577 } ] } ], "outputs" : [ { "id" : 360, "points" : [ { "x" : 2147, "y" : 753 } ] }, { "id" : 361, "points" : [ { "x" : 2171, "y" : 683 } ] } ], "catalysts" : [ { "id" : 357, "points" : [ { "x" : 2112, "y" : 577 }, { "x" : 2077, "y" : 605 } ] } ] }, { "id" : 295, "reactomeId" : 201515, "displayName" : "Active ALK recruits PI3K", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 457, "y" : 333 }, "isFadeOut" : true, "minX" : 264, "maxX" : 712, "minY" : 327, "maxY" : 339, "reactionType" : "Uncertain Process", "segments" : [ { "from" : { "x" : 712, "y" : 331 }, "to" : { "x" : 457, "y" : 333 } }, { "from" : { "x" : 457, "y" : 333 }, "to" : { "x" : 264, "y" : 332 } } ], "endShape" : { "a" : { "x" : 271, "y" : 328 }, "b" : { "x" : 264, "y" : 332 }, "c" : { "x" : 271, "y" : 336 }, "type" : "ARROW", "centre" : { "x" : 271, "y" : 336 } }, "reactionShape" : { "a" : { "x" : 451, "y" : 327 }, "b" : { "x" : 463, "y" : 339 }, "s" : "?", "type" : "BOX", "empty" : true, "centre" : { "x" : 457, "y" : 333 } }, "inputs" : [ { "id" : 296, "points" : [ { "x" : 786, "y" : 338 } ] }, { "id" : 15541, "points" : [ { "x" : 1176, "y" : 210 } ] } ], "outputs" : [ { "id" : 297 } ] }, { "id" : 103, "reactomeId" : 201521, "displayName" : "ALK autophosphorylation", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 887, "y" : 203 }, "isFadeOut" : true, "minX" : 816, "maxX" : 917, "minY" : 197, "maxY" : 209, "segments" : [ { "from" : { "x" : 816, "y" : 204 }, "to" : { "x" : 887, "y" : 203 } }, { "from" : { "x" : 887, "y" : 203 }, "to" : { "x" : 917, "y" : 203 } } ], "reactionShape" : { "a" : { "x" : 881, "y" : 197 }, "b" : { "x" : 893, "y" : 209 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 887, "y" : 203 } }, "inputs" : [ { "id" : 15519, "points" : [ { "x" : 797, "y" : 233 } ], "stoichiometry" : 6 }, { "id" : 15520, "points" : [ { "x" : 783, "y" : 203 } ] } ], "outputs" : [ { "id" : 15541, "points" : [ { "x" : 1159, "y" : 193 } ] }, { "id" : 15544, "points" : [ { "x" : 939, "y" : 225 } ], "stoichiometry" : 6 } ], "catalysts" : [ { "id" : 15520, "points" : [ { "x" : 774, "y" : 178 }, { "x" : 821, "y" : 168 } ] } ], "inhibitors" : [ { "id" : 413, "points" : [ { "x" : 895, "y" : 171 } ] } ] }, { "id" : 106, "reactomeId" : 9700200, "displayName" : "PTPRZ dephosphorylates ligand-bound ALK dimers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 305, "y" : 2352 }, "isFadeOut" : true, "minX" : 299, "maxX" : 311, "minY" : 2312, "maxY" : 2370, "segments" : [ { "from" : { "x" : 309, "y" : 2370 }, "to" : { "x" : 305, "y" : 2352 } }, { "from" : { "x" : 305, "y" : 2352 }, "to" : { "x" : 306, "y" : 2312 } } ], "reactionShape" : { "a" : { "x" : 299, "y" : 2346 }, "b" : { "x" : 311, "y" : 2358 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 305, "y" : 2352 } }, "inputs" : [ { "id" : 96, "points" : [ { "x" : 320, "y" : 2434 } ] }, { "id" : 107, "points" : [ { "x" : 400, "y" : 2396 } ], "stoichiometry" : 6 } ], "outputs" : [ { "id" : 92, "points" : [ { "x" : 315, "y" : 2234 } ] }, { "id" : 108, "points" : [ { "x" : 357, "y" : 2266 } ], "stoichiometry" : 6 } ], "catalysts" : [ { "id" : 109, "points" : [ { "x" : 217, "y" : 2228 } ] } ], "inhibitors" : [ { "id" : 116, "points" : [ { "x" : 234, "y" : 2404 } ] } ] }, { "id" : 174, "reactomeId" : 9700156, "displayName" : "Active ALK dimer binds IRS1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1469, "y" : 293 }, "isFadeOut" : true, "minX" : 1448, "maxX" : 1486, "minY" : 255, "maxY" : 298, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1448, "y" : 298 }, "to" : { "x" : 1469, "y" : 293 } }, { "from" : { "x" : 1469, "y" : 293 }, "to" : { "x" : 1486, "y" : 255 } } ], "endShape" : { "a" : { "x" : 1487, "y" : 263 }, "b" : { "x" : 1486, "y" : 255 }, "c" : { "x" : 1480, "y" : 260 }, "type" : "ARROW", "centre" : { "x" : 1480, "y" : 260 } }, "reactionShape" : { "c" : { "x" : 1469, "y" : 293 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1469, "y" : 293 } }, "inputs" : [ { "id" : 175, "points" : [ { "x" : 1421, "y" : 319 } ] }, { "id" : 15541, "points" : [ { "x" : 1232, "y" : 210 }, { "x" : 1353, "y" : 300 } ] } ], "outputs" : [ { "id" : 176 } ] }, { "id" : 177, "reactomeId" : 9700168, "displayName" : "Active ALK phosphorylates IRS1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1576, "y" : 246 }, "isFadeOut" : true, "minX" : 1559, "maxX" : 1656, "minY" : 240, "maxY" : 255, "segments" : [ { "from" : { "x" : 1559, "y" : 255 }, "to" : { "x" : 1576, "y" : 246 } }, { "from" : { "x" : 1576, "y" : 246 }, "to" : { "x" : 1656, "y" : 246 } } ], "reactionShape" : { "a" : { "x" : 1570, "y" : 240 }, "b" : { "x" : 1582, "y" : 252 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1576, "y" : 246 } }, "inputs" : [ { "id" : 178, "points" : [ { "x" : 1579, "y" : 277 } ] }, { "id" : 176, "points" : [ { "x" : 1543, "y" : 250 } ] } ], "outputs" : [ { "id" : 179, "points" : [ { "x" : 1710, "y" : 245 } ] }, { "id" : 180, "points" : [ { "x" : 1677, "y" : 277 } ] } ], "catalysts" : [ { "id" : 176, "points" : [ { "x" : 1529, "y" : 226 }, { "x" : 1574, "y" : 215 } ] } ] }, { "id" : 115, "reactomeId" : 9700121, "displayName" : "(PTN,MDK):PTPRZ oligomerizes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 193, "y" : 2373 }, "isFadeOut" : true, "minX" : 188, "maxX" : 203, "minY" : 2333, "maxY" : 2404, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 201, "y" : 2333 }, "to" : { "x" : 193, "y" : 2373 } }, { "from" : { "x" : 193, "y" : 2373 }, "to" : { "x" : 203, "y" : 2404 } } ], "endShape" : { "a" : { "x" : 197, "y" : 2399 }, "b" : { "x" : 203, "y" : 2404 }, "c" : { "x" : 205, "y" : 2396 }, "type" : "ARROW", "centre" : { "x" : 205, "y" : 2396 } }, "reactionShape" : { "c" : { "x" : 193, "y" : 2373 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 193, "y" : 2373 } }, "inputs" : [ { "id" : 114, "stoichiometry" : 6 } ], "outputs" : [ { "id" : 116 } ] }, { "id" : 307, "reactomeId" : 201510, "displayName" : "PI3K synthesizes PIP3 downstream of ALK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 247, "y" : 483 }, "isFadeOut" : true, "minX" : 241, "maxX" : 253, "minY" : 449, "maxY" : 503, "segments" : [ { "from" : { "x" : 243, "y" : 449 }, "to" : { "x" : 247, "y" : 483 } }, { "from" : { "x" : 247, "y" : 483 }, "to" : { "x" : 248, "y" : 503 } } ], "reactionShape" : { "a" : { "x" : 241, "y" : 477 }, "b" : { "x" : 253, "y" : 489 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 247, "y" : 483 } }, "inputs" : [ { "id" : 14466, "points" : [ { "x" : 250, "y" : 407 } ] }, { "id" : 14467, "points" : [ { "x" : 352, "y" : 408 } ] } ], "outputs" : [ { "id" : 310, "points" : [ { "x" : 247, "y" : 556 } ] }, { "id" : 311, "points" : [ { "x" : 323, "y" : 517 } ] } ], "catalysts" : [ { "id" : 297, "points" : [ { "x" : 207, "y" : 347 }, { "x" : 170, "y" : 451 } ] } ] }, { "id" : 15283, "reactomeId" : 9725117, "displayName" : "ALK gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1044, "y" : 1361 }, "isFadeOut" : true, "minX" : 0, "maxX" : 1287, "minY" : 85, "maxY" : 1390, "reactionType" : "Omitted Process", "segments" : [ { "from" : { "x" : 1287, "y" : 1390 }, "to" : { "x" : 1044, "y" : 1361 } }, { "from" : { "x" : 1044, "y" : 1361 }, "to" : { "x" : 803, "y" : 1374 } }, { "from" : { "x" : 803, "y" : 1374 }, "to" : { "x" : 0, "y" : 1331 } }, { "from" : { "x" : 0, "y" : 1331 }, "to" : { "x" : 4, "y" : 85 } }, { "from" : { "x" : 4, "y" : 85 }, "to" : { "x" : 130, "y" : 85 } } ], "endShape" : { "a" : { "x" : 123, "y" : 89 }, "b" : { "x" : 130, "y" : 85 }, "c" : { "x" : 123, "y" : 81 }, "type" : "ARROW", "centre" : { "x" : 123, "y" : 81 } }, "reactionShape" : { "a" : { "x" : 1038, "y" : 1355 }, "b" : { "x" : 1050, "y" : 1367 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1044, "y" : 1361 } }, "inputs" : [ { "id" : 15284 } ], "outputs" : [ { "id" : 9 } ], "activators" : [ { "id" : 15285, "points" : [ { "x" : 1242, "y" : 1314 } ] } ] }, { "id" : 181, "reactomeId" : 9700154, "displayName" : "Active ALK binds SHC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1693, "y" : 386 }, "isFadeOut" : true, "minX" : 1424, "maxX" : 1929, "minY" : 228, "maxY" : 398, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 1424, "y" : 398 }, "to" : { "x" : 1693, "y" : 386 } }, { "from" : { "x" : 1693, "y" : 386 }, "to" : { "x" : 1929, "y" : 228 } } ], "endShape" : { "a" : { "x" : 1925, "y" : 235 }, "b" : { "x" : 1929, "y" : 228 }, "c" : { "x" : 1921, "y" : 229 }, "type" : "ARROW", "centre" : { "x" : 1921, "y" : 229 } }, "reactionShape" : { "c" : { "x" : 1693, "y" : 386 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1693, "y" : 386 } }, "inputs" : [ { "id" : 15541, "points" : [ { "x" : 1229, "y" : 210 } ] }, { "id" : 182, "points" : [ { "x" : 1389, "y" : 406 } ] } ], "outputs" : [ { "id" : 183 } ] }, { "id" : 184, "reactomeId" : 9700175, "displayName" : "Active ALK phosphorylates SHC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2063, "y" : 214 }, "isFadeOut" : true, "minX" : 2040, "maxX" : 2085, "minY" : 208, "maxY" : 220, "segments" : [ { "from" : { "x" : 2040, "y" : 216 }, "to" : { "x" : 2063, "y" : 214 } }, { "from" : { "x" : 2063, "y" : 214 }, "to" : { "x" : 2085, "y" : 212 } } ], "reactionShape" : { "a" : { "x" : 2057, "y" : 208 }, "b" : { "x" : 2069, "y" : 220 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2063, "y" : 214 } }, "inputs" : [ { "id" : 185, "points" : [ { "x" : 2015, "y" : 241 } ], "stoichiometry" : 3 }, { "id" : 183, "points" : [ { "x" : 2001, "y" : 214 }, { "x" : 2021, "y" : 215 } ] } ], "outputs" : [ { "id" : 186, "points" : [ { "x" : 2142, "y" : 209 } ] }, { "id" : 187, "points" : [ { "x" : 2111, "y" : 246 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 183, "points" : [ { "x" : 1962, "y" : 199 }, { "x" : 2003, "y" : 174 } ] } ] }, { "id" : 15480, "reactomeId" : 9700662, "displayName" : "Liganded-ALK dimer binds type I ALK-binding TKIs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 745, "y" : 150 }, "isFadeOut" : true, "minX" : 613, "maxX" : 839, "minY" : 145, "maxY" : 155, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 613, "y" : 149 }, "to" : { "x" : 745, "y" : 150 } }, { "from" : { "x" : 745, "y" : 150 }, "to" : { "x" : 839, "y" : 145 } } ], "endShape" : { "a" : { "x" : 832, "y" : 149 }, "b" : { "x" : 839, "y" : 145 }, "c" : { "x" : 832, "y" : 141 }, "type" : "ARROW", "centre" : { "x" : 832, "y" : 141 } }, "reactionShape" : { "c" : { "x" : 745, "y" : 150 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 745, "y" : 150 } }, "inputs" : [ { "id" : 15520, "points" : [ { "x" : 681, "y" : 178 } ] }, { "id" : 416, "points" : [ { "x" : 540, "y" : 262 } ] } ], "outputs" : [ { "id" : 413 } ] }, { "id" : 201594, "reactomeId" : 9700114, "displayName" : "NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684", "schemaClass" : "FailedReaction", "renderableClass" : "Reaction", "position" : { "x" : 745, "y" : 150 }, "isDisease" : true, "minX" : 613, "maxX" : 839, "minY" : 145, "maxY" : 155, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 613, "y" : 149 }, "to" : { "x" : 745, "y" : 150 } }, { "from" : { "x" : 745, "y" : 150 }, "to" : { "x" : 839, "y" : 145 } } ], "endShape" : { "a" : { "x" : 832, "y" : 149 }, "b" : { "x" : 839, "y" : 145 }, "c" : { "x" : 832, "y" : 141 }, "type" : "ARROW", "centre" : { "x" : 832, "y" : 141 } }, "reactionShape" : { "a" : { "x" : 739, "y" : 144 }, "b" : { "x" : 751, "y" : 156 }, "s" : "", "type" : "BOX", "empty" : true, "centre" : { "x" : 745, "y" : 150 } }, "inputs" : [ { "id" : 201596, "points" : [ { "x" : 681, "y" : 181 } ] }, { "id" : 201595, "points" : [ { "x" : 540, "y" : 262 } ] } ], "outputs" : [ { "id" : 413 } ] }, { "id" : 13881, "reactomeId" : 9701488, "displayName" : "Active ALK phosphorylates JAK3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 298, "y" : 1520 }, "isFadeOut" : true, "minX" : 292, "maxX" : 304, "minY" : 1493, "maxY" : 1549, "segments" : [ { "from" : { "x" : 300, "y" : 1493 }, "to" : { "x" : 298, "y" : 1520 } }, { "from" : { "x" : 298, "y" : 1520 }, "to" : { "x" : 298, "y" : 1549 } } ], "reactionShape" : { "a" : { "x" : 292, "y" : 1514 }, "b" : { "x" : 304, "y" : 1526 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 298, "y" : 1520 } }, "inputs" : [ { "id" : 13882, "points" : [ { "x" : 292, "y" : 1405 } ] }, { "id" : 13883, "points" : [ { "x" : 329, "y" : 1467 } ] } ], "outputs" : [ { "id" : 13884, "points" : [ { "x" : 323, "y" : 1554 } ] }, { "id" : 13885, "points" : [ { "x" : 300, "y" : 1599 } ] } ], "catalysts" : [ { "id" : 13882, "points" : [ { "x" : 285, "y" : 1405 }, { "x" : 248, "y" : 1479 } ] } ] }, { "id" : 15998, "reactomeId" : 9701557, "displayName" : "AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2307, "y" : 1428 }, "isFadeOut" : true, "minX" : 2267, "maxX" : 2468, "minY" : 1423, "maxY" : 1433, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 2267, "y" : 1430 }, "to" : { "x" : 2307, "y" : 1428 } }, { "from" : { "x" : 2307, "y" : 1428 }, "to" : { "x" : 2468, "y" : 1428 } } ], "endShape" : { "a" : { "x" : 2461, "y" : 1432 }, "b" : { "x" : 2468, "y" : 1428 }, "c" : { "x" : 2461, "y" : 1424 }, "type" : "ARROW", "centre" : { "x" : 2461, "y" : 1424 } }, "reactionShape" : { "c" : { "x" : 2307, "y" : 1428 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2307, "y" : 1428 } }, "inputs" : [ { "id" : 14069, "points" : [ { "x" : 2191, "y" : 1468 } ] }, { "id" : 14015, "points" : [ { "x" : 2020, "y" : 1464 } ] }, { "id" : 14016, "points" : [ { "x" : 2086, "y" : 1421 } ] } ], "outputs" : [ { "id" : 14070 } ] }, { "id" : 13886, "reactomeId" : 9701485, "displayName" : "Active ALK binds JAK3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 440, "y" : 1304 }, "isFadeOut" : true, "minX" : 310, "maxX" : 512, "minY" : 1258, "maxY" : 1376, "reactionType" : "Association", "segments" : [ { "from" : { "x" : 512, "y" : 1258 }, "to" : { "x" : 440, "y" : 1304 } }, { "from" : { "x" : 440, "y" : 1304 }, "to" : { "x" : 310, "y" : 1376 } } ], "endShape" : { "a" : { "x" : 314, "y" : 1369 }, "b" : { "x" : 310, "y" : 1376 }, "c" : { "x" : 318, "y" : 1376 }, "type" : "ARROW", "centre" : { "x" : 318, "y" : 1376 } }, "reactionShape" : { "c" : { "x" : 440, "y" : 1304 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 440, "y" : 1304 } }, "inputs" : [ { "id" : 13887, "points" : [ { "x" : 604, "y" : 1303 } ] }, { "id" : 15541, "points" : [ { "x" : 1215, "y" : 210 }, { "x" : 1112, "y" : 709 } ] } ], "outputs" : [ { "id" : 13882 } ] } ], "compartments" : [ { "id" : 2, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1639, "y" : 1731 }, "minX" : 231, "maxX" : 3047, "minY" : 71, "maxY" : 3391, "prop" : { "x" : 231, "y" : 71, "width" : 2816, "height" : 3320 }, "textPosition" : { "x" : 863, "y" : 349 }, "insets" : { "x" : 307, "y" : 248, "width" : 2710, "height" : 3102 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 10, 13, 28, 92, 93, 94, 103, 107, 108, 174, 175, 176, 177, 178, 179, 180, 183, 181, 182, 184, 185, 186, 187, 191, 193, 195, 221, 222, 220, 226, 228, 295, 296, 297, 310, 311, 307, 321, 326, 340, 341, 337, 338, 348, 352, 354, 355, 356, 357, 358, 359, 360, 361, 416, 13574, 13575, 13576, 13577, 13578, 13579, 13580, 13587, 13588, 13589, 13590, 13591, 13592, 30, 114, 116, 413, 13614, 13612, 13618, 13621, 13622, 13885, 13881, 13882, 13883, 13886, 13887, 13884, 13891, 13892, 13894, 13896, 13897, 13898, 13903, 13977, 14229, 14231, 14230, 14232, 14233, 14234, 14236, 14426, 14429, 14434, 14466, 14467, 14561, 14562, 14564, 14565, 14566, 14567, 14570, 14574, 14601, 14602, 14607, 14608, 14611, 14708, 14709, 14710, 14711, 14712, 14713, 14773, 14774, 14779, 14780, 14781, 14783, 14784, 14832, 14872, 14873, 14874, 14925, 14926, 15091, 15118, 15196, 15198, 15221, 15275, 14782, 15475, 15480, 27, 15512, 15513, 15519, 15520, 15521, 15522, 15523, 15541, 15543, 15544, 96, 336, 339, 106, 109, 7, 15276, 15654, 13907, 13978, 14101, 14078, 15283, 15784, 15790, 15792, 15891, 15911, 15912, 15910, 15785, 15436, 15434, 15728, 15821, 16007, 15997, 16125, 16183, 16184, 15462, 16212, 16213, 16214, 16215, 16366, 16370, 16371, 16394, 16395, 16396, 16438, 16439, 16617, 16618, 16619, 16620, 16621, 16622, 16229, 16005, 16761, 16763, 16910, 16909, 16908 ] }, { "id" : 16125, "reactomeId" : 8857380, "displayName" : "cytolytic granule lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2170, "y" : 3193 }, "minX" : 2058, "maxX" : 2283, "minY" : 3142, "maxY" : 3245, "prop" : { "x" : 2058, "y" : 3142, "width" : 225, "height" : 103 }, "textPosition" : { "x" : 2095, "y" : 3193 }, "insets" : { "x" : 2070, "y" : 3157, "width" : 197, "height" : 79 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 16124, 16128 ] }, { "id" : 13903, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1943, "y" : 2084 }, "minX" : 1174, "maxX" : 2713, "minY" : 1072, "maxY" : 3097, "prop" : { "x" : 1174, "y" : 1072, "width" : 1539, "height" : 2025 }, "textPosition" : { "x" : 1769, "y" : 1102 }, "insets" : { "x" : 1202, "y" : 1099, "width" : 1486, "height" : 1976 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 13980, 14015, 14016, 14017, 14018, 14020, 14034, 14035, 14036, 14054, 14070, 14069, 14083, 14084, 14086, 14087, 14090, 14089, 14088, 14091, 14094, 14095, 14096, 14097, 14098, 14099, 14100, 14092, 14839, 14837, 14838, 14846, 15258, 15259, 15260, 15261, 15262, 15263, 15264, 15266, 15265, 15284, 15285, 15326, 15325, 15408, 15409, 15410, 15413, 15460, 15461, 15474, 15472, 15473, 15550, 15551, 13979, 15631, 15632, 15274, 15653, 15671, 15672, 15673, 15435, 15674, 15723, 15724, 15726, 15727, 15737, 15738, 15740, 15741, 15746, 15748, 15747, 15625, 15773, 15783, 15817, 15818, 15819, 15820, 15838, 15844, 15883, 15885, 15890, 15926, 15927, 15782, 15925, 15909, 15991, 15992, 15998, 16003, 16020, 16061, 16063, 16120, 16121, 16122, 16123, 14847, 15989, 16062, 15884, 16126, 16127, 14777, 16182, 16181, 16398, 16419, 16422, 16421, 16425, 16424, 16430, 16431, 16432, 16452, 16659, 16664, 16682, 16372, 16769, 16813, 16906, 16907, 17163, 17176, 17177, 17178, 17180 ] } ], "notes" : [ ], "links" : [ { "id" : 193, "renderableClass" : "Interaction", "position" : { "x" : 1932, "y" : 303 }, "isFadeOut" : true, "minX" : 1805, "maxX" : 2059, "minY" : 260, "maxY" : 347, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1805, "y" : 260 }, "to" : { "x" : 2059, "y" : 347 } } ], "endShape" : { "a" : { "x" : 2051, "y" : 349 }, "b" : { "x" : 2059, "y" : 347 }, "c" : { "x" : 2054, "y" : 341 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2054, "y" : 341 } }, "reactionShape" : { "a" : { "x" : 1926, "y" : 297 }, "b" : { "x" : 1938, "y" : 309 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1932, "y" : 303 } }, "inputs" : [ { "id" : 179 } ], "outputs" : [ { "id" : 191 } ] }, { "id" : 15521, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 422, "y" : 1847 }, "isFadeOut" : true, "minX" : 234, "maxX" : 714, "minY" : 227, "maxY" : 2101, "segments" : [ { "from" : { "x" : 234, "y" : 2101 }, "to" : { "x" : 422, "y" : 1847 } }, { "from" : { "x" : 422, "y" : 1847 }, "to" : { "x" : 714, "y" : 227 } } ], "reactionShape" : { "a" : { "x" : 416, "y" : 1841 }, "b" : { "x" : 428, "y" : 1853 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 422, "y" : 1847 } }, "inputs" : [ { "id" : 30 } ], "outputs" : [ { "id" : 15520 } ] }, { "id" : 354, "renderableClass" : "Interaction", "position" : { "x" : 348, "y" : 1143 }, "isFadeOut" : true, "minX" : 313, "maxX" : 384, "minY" : 1134, "maxY" : 1152, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 313, "y" : 1134 }, "to" : { "x" : 384, "y" : 1152 } } ], "endShape" : { "a" : { "x" : 376, "y" : 1154 }, "b" : { "x" : 384, "y" : 1152 }, "c" : { "x" : 378, "y" : 1146 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 378, "y" : 1146 } }, "reactionShape" : { "a" : { "x" : 342, "y" : 1137 }, "b" : { "x" : 354, "y" : 1149 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 348, "y" : 1143 } }, "inputs" : [ { "id" : 341 } ], "outputs" : [ { "id" : 352 } ] }, { "id" : 15522, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 468, "y" : 1905 }, "isFadeOut" : true, "minX" : 333, "maxX" : 715, "minY" : 227, "maxY" : 2072, "segments" : [ { "from" : { "x" : 333, "y" : 2072 }, "to" : { "x" : 468, "y" : 1905 } }, { "from" : { "x" : 468, "y" : 1905 }, "to" : { "x" : 715, "y" : 227 } } ], "reactionShape" : { "a" : { "x" : 462, "y" : 1899 }, "b" : { "x" : 474, "y" : 1911 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 468, "y" : 1905 } }, "inputs" : [ { "id" : 28 } ], "outputs" : [ { "id" : 15520 } ] }, { "id" : 195, "renderableClass" : "Interaction", "position" : { "x" : 2163, "y" : 283 }, "isFadeOut" : true, "minX" : 2137, "maxX" : 2189, "minY" : 230, "maxY" : 337, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2189, "y" : 230 }, "to" : { "x" : 2137, "y" : 337 } } ], "endShape" : { "a" : { "x" : 2136, "y" : 329 }, "b" : { "x" : 2137, "y" : 337 }, "c" : { "x" : 2144, "y" : 333 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2144, "y" : 333 } }, "reactionShape" : { "a" : { "x" : 2157, "y" : 277 }, "b" : { "x" : 2169, "y" : 289 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2163, "y" : 283 } }, "inputs" : [ { "id" : 186 } ], "outputs" : [ { "id" : 191 } ] }, { "id" : 15523, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 600, "y" : 181 }, "isFadeOut" : true, "minX" : 547, "maxX" : 653, "minY" : 171, "maxY" : 191, "segments" : [ { "from" : { "x" : 547, "y" : 171 }, "to" : { "x" : 653, "y" : 191 } } ], "reactionShape" : { "a" : { "x" : 594, "y" : 175 }, "b" : { "x" : 606, "y" : 187 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 600, "y" : 181 } }, "inputs" : [ { "id" : 15512 } ], "outputs" : [ { "id" : 15520 } ] }, { "id" : 326, "renderableClass" : "Interaction", "position" : { "x" : 495, "y" : 572 }, "isFadeOut" : true, "minX" : 291, "maxX" : 699, "minY" : 566, "maxY" : 578, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 291, "y" : 573 }, "to" : { "x" : 699, "y" : 572 } } ], "endShape" : { "a" : { "x" : 692, "y" : 576 }, "b" : { "x" : 699, "y" : 572 }, "c" : { "x" : 692, "y" : 568 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 692, "y" : 568 } }, "reactionShape" : { "a" : { "x" : 489, "y" : 566 }, "b" : { "x" : 501, "y" : 578 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 495, "y" : 572 } }, "inputs" : [ { "id" : 310 } ], "outputs" : [ { "id" : 321 } ] }, { "id" : 15543, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 771, "y" : 1322 }, "isFadeOut" : true, "minX" : 330, "maxX" : 1213, "minY" : 210, "maxY" : 2434, "segments" : [ { "from" : { "x" : 1213, "y" : 210 }, "to" : { "x" : 330, "y" : 2434 } } ], "reactionShape" : { "a" : { "x" : 765, "y" : 1316 }, "b" : { "x" : 777, "y" : 1328 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 771, "y" : 1322 } }, "inputs" : [ { "id" : 15541 } ], "outputs" : [ { "id" : 96 } ] }, { "id" : 15623, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 146, "y" : 1848 }, "isFadeOut" : true, "minX" : 121, "maxX" : 171, "minY" : 1724, "maxY" : 1973, "segments" : [ { "from" : { "x" : 171, "y" : 1724 }, "to" : { "x" : 121, "y" : 1973 } } ], "reactionShape" : { "a" : { "x" : 140, "y" : 1842 }, "b" : { "x" : 152, "y" : 1854 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 146, "y" : 1848 } }, "inputs" : [ { "id" : 8 } ], "outputs" : [ { "id" : 15622 } ] }, { "id" : 15624, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 111, "y" : 1847 }, "isFadeOut" : true, "minX" : 104, "maxX" : 118, "minY" : 1722, "maxY" : 1973, "segments" : [ { "from" : { "x" : 104, "y" : 1722 }, "to" : { "x" : 118, "y" : 1973 } } ], "reactionShape" : { "a" : { "x" : 105, "y" : 1841 }, "b" : { "x" : 117, "y" : 1853 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 111, "y" : 1847 } }, "inputs" : [ { "id" : 12 } ], "outputs" : [ { "id" : 15622 } ] }, { "id" : 93, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 268, "y" : 2157 }, "isFadeOut" : true, "minX" : 237, "maxX" : 299, "minY" : 2130, "maxY" : 2185, "segments" : [ { "from" : { "x" : 237, "y" : 2130 }, "to" : { "x" : 299, "y" : 2185 } } ], "reactionShape" : { "a" : { "x" : 262, "y" : 2151 }, "b" : { "x" : 274, "y" : 2163 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 268, "y" : 2157 } }, "inputs" : [ { "id" : 30 } ], "outputs" : [ { "id" : 92 } ] }, { "id" : 94, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 320, "y" : 2143 }, "isFadeOut" : true, "minX" : 314, "maxX" : 326, "minY" : 2101, "maxY" : 2185, "segments" : [ { "from" : { "x" : 323, "y" : 2101 }, "to" : { "x" : 318, "y" : 2185 } } ], "reactionShape" : { "a" : { "x" : 314, "y" : 2137 }, "b" : { "x" : 326, "y" : 2149 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 320, "y" : 2143 } }, "inputs" : [ { "id" : 28 } ], "outputs" : [ { "id" : 92 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 3047, "minY" : 0, "maxY" : 3399, "disease" : true }