{
  "dbId" : 9686114,
  "stId" : "R-HSA-9686114",
  "speciesName" : "Homo sapiens",
  "nodes" : [ {
    "dbId" : 449030,
    "stId" : "R-HSA-449030",
    "displayName" : "IL1B(1-116) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 512 ],
    "identifier" : "P01584",
    "standardIdentifier" : "uniprot:P01584",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1B", "IL1F2" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9710102,
    "stId" : "R-HSA-9710102",
    "displayName" : "activated CASP5 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 41 ],
    "parents" : [ ],
    "children" : [ 9710090 ]
  }, {
    "dbId" : 9710096,
    "stId" : "R-HSA-9710096",
    "displayName" : "CASP4(290-377) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P49662",
    "standardIdentifier" : "uniprot:P49662",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP4", "ICH2" ],
    "parents" : [ 9710094 ],
    "children" : [ ]
  }, {
    "dbId" : 1031691,
    "stId" : "R-HSA-1031691",
    "displayName" : "GBP4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q96PP9",
    "standardIdentifier" : "uniprot:Q96PP9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GBP4" ],
    "parents" : [ 9947857 ],
    "children" : [ ]
  }, {
    "dbId" : 9953170,
    "stId" : "R-HSA-9953170",
    "displayName" : "GBP-mediated host defense",
    "schemaClass" : "Pathway",
    "speciesId" : 48887,
    "diagramIds" : [ 24 ]
  }, {
    "dbId" : 9710097,
    "stId" : "R-HSA-9710097",
    "displayName" : "activated CASP4 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 10 ],
    "parents" : [ ],
    "children" : [ 9710094 ]
  }, {
    "dbId" : 9647641,
    "stId" : "R-HSA-9647641",
    "displayName" : "GSDMD(1-275) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 22 ],
    "identifier" : "P57764",
    "standardIdentifier" : "uniprot:P57764",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GSDMD", "DFNA5L", "GSDMDC1", "FKSG10" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9016707,
    "stId" : "R-HSA-9016707",
    "displayName" : "CALM1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P0DP23",
    "standardIdentifier" : "uniprot:P0DP23",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CALM1", "CALM", "CAM", "CAM1" ],
    "parents" : [ 9958605 ],
    "children" : [ ]
  }, {
    "dbId" : 9710105,
    "stId" : "R-HSA-9710105",
    "displayName" : "CASP5(137-327) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P51878",
    "standardIdentifier" : "uniprot:P51878",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP5", "ICH3" ],
    "parents" : [ 9710090 ],
    "children" : [ ]
  }, {
    "dbId" : 449033,
    "stId" : "R-HSA-449033",
    "displayName" : "IL18(1-193) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 507 ],
    "identifier" : "Q14116",
    "standardIdentifier" : "uniprot:Q14116",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL18", "IGIF", "IL1F4" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 449046,
    "stId" : "R-HSA-449046",
    "displayName" : "IL1B(117-269) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 511 ],
    "identifier" : "P01584",
    "standardIdentifier" : "uniprot:P01584",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1B", "IL1F2" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9947911,
    "stId" : "R-HSA-9947911",
    "displayName" : "2xCASP5:LPS micelles [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 39 ],
    "parents" : [ ],
    "children" : [ 9686105, 9686132 ]
  }, {
    "dbId" : 350870,
    "stId" : "R-HSA-350870",
    "displayName" : "Caspase-3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 23 ],
    "parents" : [ ],
    "children" : [ 350888 ]
  }, {
    "dbId" : 9710094,
    "stId" : "R-HSA-9710094",
    "displayName" : "CASP4(?81-270):CASP4(290-377) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 9710097 ],
    "children" : [ 9710121, 9710096 ]
  }, {
    "dbId" : 9710090,
    "stId" : "R-HSA-9710090",
    "displayName" : "CASP5(137-327):CASP5(347-434) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 9710102 ],
    "children" : [ 9710073, 9710105 ]
  }, {
    "dbId" : 9947912,
    "stId" : "R-HSA-9947912",
    "displayName" : "S-farn-C589-GBP1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P32455",
    "standardIdentifier" : "uniprot:P32455",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GBP1" ],
    "parents" : [ 9947869 ],
    "children" : [ ]
  }, {
    "dbId" : 1031696,
    "stId" : "R-HSA-1031696",
    "displayName" : "GBP3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q9H0R5",
    "standardIdentifier" : "uniprot:Q9H0R5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GBP3" ],
    "parents" : [ 9947857 ],
    "children" : [ ]
  }, {
    "dbId" : 449062,
    "stId" : "R-HSA-449062",
    "displayName" : "IL18(1-36) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 509 ],
    "identifier" : "Q14116",
    "standardIdentifier" : "uniprot:Q14116",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL18", "IGIF", "IL1F4" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9956663,
    "stId" : "R-SFL-9956663",
    "displayName" : "OspC3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 9955275,
    "identifier" : "A0A0H2US87",
    "standardIdentifier" : "uniprot:A0A0H2US87",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ospC3", "CP0115", "SF_p0115" ],
    "parents" : [ 9956652 ],
    "children" : [ ]
  }, {
    "dbId" : 9647672,
    "stId" : "R-HSA-9647672",
    "displayName" : "GSDMD(276-484) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 21 ],
    "identifier" : "P57764",
    "standardIdentifier" : "uniprot:P57764",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GSDMD", "DFNA5L", "GSDMDC1", "FKSG10" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113578,
    "stId" : "R-ALL-113578",
    "displayName" : "GMP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "58115",
    "standardIdentifier" : "chebi:58115",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 9947870 ],
    "children" : [ ]
  }, {
    "dbId" : 350888,
    "stId" : "R-HSA-350888",
    "displayName" : "CASP3(29-175):CASP3(176-277) [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 350870 ],
    "children" : [ 141644, 141646 ]
  }, {
    "dbId" : 9947833,
    "stId" : "R-HSA-9947833",
    "displayName" : "CASP4(271-289) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 11 ],
    "identifier" : "P49662",
    "standardIdentifier" : "uniprot:P49662",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP4", "ICH2" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9960484,
    "stId" : "R-HSA-9960484",
    "displayName" : "CALM:OspC3:CASP4:LPS:GBPs [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 488 ],
    "parents" : [ ],
    "children" : [ 9956652, 9947938 ]
  }, {
    "dbId" : 9947938,
    "stId" : "R-HSA-9947938",
    "displayName" : "2xCASP4:LPS:(GBP1:GBP2:GBP3:GBP4:GDP) oligomer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 17 ],
    "parents" : [ 9960484 ],
    "children" : [ 622418, 9947891 ]
  }, {
    "dbId" : 448689,
    "stId" : "R-HSA-448689",
    "displayName" : "IL1B(1-269) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 485 ],
    "identifier" : "P01584",
    "standardIdentifier" : "uniprot:P01584",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1B", "IL1F2" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9956640,
    "stId" : "R-HSA-9956640",
    "displayName" : "CALM:OspC3:CASP4:LPS [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 61 ],
    "parents" : [ ],
    "children" : [ 9686270, 9956652 ]
  }, {
    "dbId" : 9956652,
    "stId" : "R-HSA-9956652",
    "displayName" : "CALM:OspC3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 9960484, 9956640 ],
    "children" : [ 9958605, 9956663 ]
  }, {
    "dbId" : 9710121,
    "stId" : "R-HSA-9710121",
    "displayName" : "CASP4(?81-270) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P49662",
    "standardIdentifier" : "uniprot:P49662",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP4", "ICH2" ],
    "parents" : [ 9710094 ],
    "children" : [ ]
  }, {
    "dbId" : 5620971,
    "stId" : "R-HSA-5620971",
    "displayName" : "Pyroptosis",
    "schemaClass" : "Pathway",
    "speciesId" : 48887,
    "diagramIds" : [ 47 ]
  }, {
    "dbId" : 9947863,
    "stId" : "R-HSA-9947863",
    "displayName" : "GBP1 oligomer:GDP:LPS [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 9947898 ],
    "children" : [ 6803081, 29420, 9947869 ]
  }, {
    "dbId" : 9947857,
    "stId" : "R-HSA-9947857",
    "displayName" : "LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GDP [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 9947891 ],
    "children" : [ 1031696, 9947898, 9947851, 29420, 1031691 ]
  }, {
    "dbId" : 9947870,
    "stId" : "R-HSA-9947870",
    "displayName" : "GBP1 oligomer:GMP:LPS [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 9947898 ],
    "children" : [ 6803081, 113578, 9947869 ]
  }, {
    "dbId" : 9686105,
    "stId" : "R-ALL-9686105",
    "displayName" : "LPS micelles [bacterial outer membrane vesicle]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 3 ],
    "identifier" : "16412",
    "standardIdentifier" : "chebi:16412",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 9686270, 9686083, 9686087, 9947911 ],
    "children" : [ ]
  }, {
    "dbId" : 9947869,
    "stId" : "R-HSA-9947869",
    "displayName" : "GBP1 oligomer [cytosol]",
    "schemaClass" : "Polymer",
    "speciesId" : 48887,
    "parents" : [ 9947870, 9947863 ],
    "children" : [ 9947912 ]
  }, {
    "dbId" : 141646,
    "stId" : "R-HSA-141646",
    "displayName" : "CASP3(176-277) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P42574",
    "standardIdentifier" : "uniprot:P42574",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP3", "CPP32" ],
    "parents" : [ 350888 ],
    "children" : [ ]
  }, {
    "dbId" : 6801577,
    "stId" : "R-HSA-6801577",
    "displayName" : "GSDMD [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 20 ],
    "identifier" : "P57764",
    "standardIdentifier" : "uniprot:P57764",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GSDMD", "DFNA5L", "GSDMDC1", "FKSG10" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 141644,
    "stId" : "R-HSA-141644",
    "displayName" : "CASP3(29-175) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P42574",
    "standardIdentifier" : "uniprot:P42574",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP3", "CPP32" ],
    "parents" : [ 350888 ],
    "children" : [ ]
  }, {
    "dbId" : 9958616,
    "stId" : "R-HSA-9958616",
    "displayName" : "IL1B(1-27) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 486 ],
    "identifier" : "P01584",
    "standardIdentifier" : "uniprot:P01584",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL1B", "IL1F2" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9686083,
    "stId" : "R-HSA-9686083",
    "displayName" : "CASP4:LPS micelles [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 5 ],
    "parents" : [ ],
    "children" : [ 622418, 9686105 ]
  }, {
    "dbId" : 8962908,
    "stId" : "R-HSA-8962908",
    "displayName" : "SERPINB1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 33 ],
    "identifier" : "P30740",
    "standardIdentifier" : "uniprot:P30740",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SERPINB1", "ELANH2", "MNEI", "PI2" ],
    "parents" : [ 9948159 ],
    "children" : [ ]
  }, {
    "dbId" : 9686087,
    "stId" : "R-HSA-9686087",
    "displayName" : "CASP5(1-434):LPS micelles [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 36 ],
    "parents" : [ ],
    "children" : [ 9686105, 9686132 ]
  }, {
    "dbId" : 9958606,
    "stId" : "R-HSA-9958606",
    "displayName" : "CALM3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P0DP25",
    "standardIdentifier" : "uniprot:P0DP25",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CALM3", "CALML2", "CAM3", "CAMC", "CAMIII" ],
    "parents" : [ 9958605 ],
    "children" : [ ]
  }, {
    "dbId" : 9958605,
    "stId" : "R-HSA-9958605",
    "displayName" : "CALM [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "parents" : [ 9956652 ],
    "children" : [ 9958603, 9016707, 9958606 ]
  }, {
    "dbId" : 622418,
    "stId" : "R-HSA-622418",
    "displayName" : "CASP4(?-377) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 4 ],
    "identifier" : "P49662",
    "standardIdentifier" : "uniprot:P49662",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP4", "ICH2" ],
    "parents" : [ 9947893, 9947938, 9948159, 9686083, 9686270 ],
    "children" : [ ]
  }, {
    "dbId" : 9958603,
    "stId" : "R-HSA-9958603",
    "displayName" : "CALM2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P0DP24",
    "standardIdentifier" : "uniprot:P0DP24",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CALM2", "CAM2", "CAMB" ],
    "parents" : [ 9958605 ],
    "children" : [ ]
  }, {
    "dbId" : 9947851,
    "stId" : "R-HSA-9947851",
    "displayName" : "GGC-C588-GBP2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P32456",
    "standardIdentifier" : "uniprot:P32456",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GBP2" ],
    "parents" : [ 9947857 ],
    "children" : [ ]
  }, {
    "dbId" : 9947893,
    "stId" : "R-HSA-9947893",
    "displayName" : "CASP4:LPS:(GBP1:GBP2:GBP3:GBP4:GDP) oligomer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 14 ],
    "parents" : [ ],
    "children" : [ 622418, 9947891 ]
  }, {
    "dbId" : 9947891,
    "stId" : "R-HSA-9947891",
    "displayName" : "LPS:(GBP1:GBP2:GBP3:GBP4) oligomer [cytosol]",
    "schemaClass" : "Polymer",
    "speciesId" : 48887,
    "diagramIds" : [ 487 ],
    "parents" : [ 9947893, 9947938 ],
    "children" : [ 9947857 ]
  }, {
    "dbId" : 9956593,
    "stId" : "R-HSA-9956593",
    "displayName" : "Enterobacterial factors antagonize host defense ",
    "schemaClass" : "Pathway",
    "speciesId" : 48887,
    "diagramIds" : [ 179 ]
  }, {
    "dbId" : 9686132,
    "stId" : "R-HSA-9686132",
    "displayName" : "CASP5(1-434) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 35 ],
    "identifier" : "P51878",
    "standardIdentifier" : "uniprot:P51878",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP5", "ICH3" ],
    "parents" : [ 9947911, 9686087 ],
    "children" : [ ]
  }, {
    "dbId" : 9948159,
    "stId" : "R-HSA-9948159",
    "displayName" : "CASP4:SERPINB1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 8 ],
    "parents" : [ ],
    "children" : [ 622418, 8962908 ]
  }, {
    "dbId" : 29420,
    "stId" : "R-ALL-29420",
    "displayName" : "GDP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "58189",
    "standardIdentifier" : "chebi:58189",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 9947863, 9947857 ],
    "children" : [ ]
  }, {
    "dbId" : 9686270,
    "stId" : "R-HSA-9686270",
    "displayName" : "2xCASP4:LPS micelles [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 7 ],
    "parents" : [ 9956640 ],
    "children" : [ 622418, 9686105 ]
  }, {
    "dbId" : 9947898,
    "stId" : "R-HSA-9947898",
    "displayName" : "LPS-bound GBP1 oligomer [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "parents" : [ 9947857 ],
    "children" : [ 9947870, 9947863 ]
  }, {
    "dbId" : 9710073,
    "stId" : "R-HSA-9710073",
    "displayName" : "CASP5(347-434) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P51878",
    "standardIdentifier" : "uniprot:P51878",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CASP5", "ICH3" ],
    "parents" : [ 9710090 ],
    "children" : [ ]
  }, {
    "dbId" : 6803081,
    "stId" : "R-ALL-6803081",
    "displayName" : "LPS [peptidoglycan-based cell wall]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "16412",
    "standardIdentifier" : "chebi:16412",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 9947863, 9947870 ],
    "children" : [ ]
  }, {
    "dbId" : 449023,
    "stId" : "R-HSA-449023",
    "displayName" : "IL18(37-193) [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 508 ],
    "identifier" : "Q14116",
    "standardIdentifier" : "uniprot:Q14116",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "IL18", "IGIF", "IL1F4" ],
    "parents" : [ ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 9947861,
    "stId" : "R-HSA-9947861",
    "displayName" : "CASP4 autocatalysis on LPS micelles",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 9686271 ],
    "following" : [ 9958657, 9960526, 9947987, 9948146 ],
    "inputs" : [ 9686270 ],
    "outputs" : [ 9947833, 9686105, 9710097 ],
    "catalysts" : [ 9686270 ],
    "efs" : [ ],
    "inhibitors" : [ 9956640 ],
    "diagramIds" : [ 9 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9686096,
    "stId" : "R-HSA-9686096",
    "displayName" : "CASP4 binds LPS micelles",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 9686271 ],
    "inputs" : [ 622418, 9686105 ],
    "outputs" : [ 9686083 ],
    "efs" : [ ],
    "diagramIds" : [ 2 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9947987,
    "stId" : "R-HSA-9947987",
    "displayName" : "CASP4 cleaves IL18 at D36 ",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 9947908, 9947861 ],
    "inputs" : [ 449033 ],
    "outputs" : [ 449023, 449062 ],
    "catalysts" : [ 9710097 ],
    "efs" : [ ],
    "diagramIds" : [ 27 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9948146,
    "stId" : "R-HSA-9948146",
    "displayName" : "CASP4 cleaves GSDMD",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 9947908, 9947861 ],
    "inputs" : [ 6801577 ],
    "outputs" : [ 9647672, 9647641 ],
    "catalysts" : [ 9710097 ],
    "efs" : [ ],
    "inhibitors" : [ 350870 ],
    "diagramIds" : [ 19 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9686100,
    "stId" : "R-HSA-9686100",
    "displayName" : "CASP5 binds LPS micelles",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 9947937 ],
    "inputs" : [ 9686105, 9686132 ],
    "outputs" : [ 9686087 ],
    "efs" : [ ],
    "diagramIds" : [ 34 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9947934,
    "stId" : "R-HSA-9947934",
    "displayName" : "CASP4 binds exposed LPS on the bacterial surface",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 9947940 ],
    "inputs" : [ 622418, 9947891 ],
    "outputs" : [ 9947893 ],
    "efs" : [ ],
    "diagramIds" : [ 12 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9947997,
    "stId" : "R-HSA-9947997",
    "displayName" : "CASP5 cleaves GSDMD",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 9947849 ],
    "inputs" : [ 6801577 ],
    "outputs" : [ 9647672, 9647641 ],
    "catalysts" : [ 9710102 ],
    "efs" : [ ],
    "inhibitors" : [ 350870 ],
    "diagramIds" : [ 42 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9686271,
    "stId" : "R-HSA-9686271",
    "displayName" : "CASP4 dimerizes",
    "schemaClass" : "Polymerisation",
    "speciesId" : 0,
    "preceding" : [ 9686096 ],
    "following" : [ 9947861 ],
    "inputs" : [ 622418, 9686083 ],
    "outputs" : [ 9686270 ],
    "efs" : [ ],
    "inhibitors" : [ 9948159 ],
    "diagramIds" : [ 6 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9947940,
    "stId" : "R-HSA-9947940",
    "displayName" : "CASP4 forms dimers on the bacterial surface",
    "schemaClass" : "Polymerisation",
    "speciesId" : 0,
    "preceding" : [ 9947934 ],
    "following" : [ 9947908 ],
    "inputs" : [ 622418, 9947893 ],
    "outputs" : [ 9947938 ],
    "efs" : [ ],
    "inhibitors" : [ 9948159 ],
    "diagramIds" : [ 16 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9947908,
    "stId" : "R-HSA-9947908",
    "displayName" : "CASP4 autocatalysis on the bacterial surface",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9947940 ],
    "following" : [ 9958657, 9960526, 9947987, 9948146 ],
    "inputs" : [ 9947938 ],
    "outputs" : [ 9947833, 9710097, 9947891 ],
    "catalysts" : [ 9947938 ],
    "efs" : [ ],
    "inhibitors" : [ 9960484 ],
    "diagramIds" : [ 18 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9958657,
    "stId" : "R-HSA-9958657",
    "displayName" : "CASP4 cleaves IL1B at D27",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 9947908, 9947861 ],
    "inputs" : [ 448689 ],
    "outputs" : [ 9958616 ],
    "catalysts" : [ 9710097 ],
    "efs" : [ ],
    "diagramIds" : [ 484 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9947937,
    "stId" : "R-HSA-9947937",
    "displayName" : "CASP5 dimerizes",
    "schemaClass" : "Polymerisation",
    "speciesId" : 0,
    "preceding" : [ 9686100 ],
    "following" : [ 9947849 ],
    "inputs" : [ 9686132, 9686087 ],
    "outputs" : [ 9947911 ],
    "efs" : [ ],
    "diagramIds" : [ 38 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9948160,
    "stId" : "R-HSA-9948160",
    "displayName" : "SERPINB1 binds CASP4",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 622418, 8962908 ],
    "outputs" : [ 9948159 ],
    "efs" : [ ],
    "diagramIds" : [ 32 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9960526,
    "stId" : "R-HSA-9960526",
    "displayName" : "CASP4 cleaves IL1B at D116",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 9947908, 9947861 ],
    "inputs" : [ 448689 ],
    "outputs" : [ 449030, 449046 ],
    "catalysts" : [ 9710097 ],
    "efs" : [ ],
    "diagramIds" : [ 510 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9947978,
    "stId" : "R-HSA-9947978",
    "displayName" : "CASP5 cleaves IL18 at D36",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 9947849 ],
    "inputs" : [ 449033 ],
    "outputs" : [ 449023, 449062 ],
    "catalysts" : [ 9710102 ],
    "efs" : [ ],
    "diagramIds" : [ 44 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9960522,
    "stId" : "R-HSA-9960522",
    "displayName" : "CASP5 cleaves IL1B at D27",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 9947849 ],
    "inputs" : [ 448689 ],
    "outputs" : [ 9958616 ],
    "catalysts" : [ 9710102 ],
    "efs" : [ ],
    "diagramIds" : [ 513 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9947849,
    "stId" : "R-HSA-9947849",
    "displayName" : "CASP5 autocatalysis on LPS micelles",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 9947937 ],
    "following" : [ 9960522, 9947978, 9947997 ],
    "inputs" : [ 9947911 ],
    "outputs" : [ 9686105, 9710102 ],
    "catalysts" : [ 9947911 ],
    "efs" : [ ],
    "diagramIds" : [ 40 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 9948011,
    "stId" : "R-HSA-9948011",
    "displayName" : "CASP5 inflammasome assembly",
    "events" : [ 9947937, 9686100, 9947849 ]
  }, {
    "dbId" : 9960519,
    "stId" : "R-HSA-9960519",
    "displayName" : "CASP4-mediated substrate cleavage",
    "events" : [ 9947987, 9948146, 9958657, 9960526 ]
  }, {
    "dbId" : 9948001,
    "stId" : "R-HSA-9948001",
    "displayName" : "CASP4 inflammasome assembly",
    "events" : [ 9947861, 9686096, 9947940, 9947908, 9948160, 9947934, 9686271 ]
  }, {
    "dbId" : 9960525,
    "stId" : "R-HSA-9960525",
    "displayName" : "CASP5-mediated substrate cleavage",
    "events" : [ 9947997, 9947978, 9960522 ]
  } ]
}