{
  "dbId" : 9673221,
  "stId" : "R-HSA-9673221",
  "speciesName" : "Homo sapiens",
  "nodes" : [ {
    "dbId" : 74112,
    "stId" : "R-ALL-74112",
    "displayName" : "Ca2+ [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 1312, 1957, 1126, 8, 1450 ],
    "identifier" : "29108",
    "standardIdentifier" : "chebi:29108",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9673205,
    "stId" : "R-HSA-9673205",
    "displayName" : "F9(29-461) R43L [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P00740",
    "standardIdentifier" : "uniprot:P00740",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "F9" ],
    "parents" : [ 9673225 ],
    "children" : [ ]
  }, {
    "dbId" : 9673403,
    "stId" : "R-HSA-9673403",
    "displayName" : "12xCbxE-3D-F9(47-461) R226W [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P00740",
    "standardIdentifier" : "uniprot:P00740",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "F9" ],
    "parents" : [ 9673225 ],
    "children" : [ ]
  }, {
    "dbId" : 55881,
    "stId" : "R-HSA-55881",
    "displayName" : "GP9 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P14770",
    "standardIdentifier" : "uniprot:P14770",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GP9" ],
    "parents" : [ 114668 ],
    "children" : [ ]
  }, {
    "dbId" : 114667,
    "stId" : "R-HSA-114667",
    "displayName" : "GPIb [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 114668 ],
    "children" : [ 55863, 55861 ]
  }, {
    "dbId" : 114668,
    "stId" : "R-HSA-114668",
    "displayName" : "GPIb-IX-V [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 1036 ],
    "parents" : [ 158130 ],
    "children" : [ 55899, 114667, 55881 ]
  }, {
    "dbId" : 158124,
    "stId" : "R-HSA-158124",
    "displayName" : "factor XIa light chain [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P03951",
    "standardIdentifier" : "uniprot:P03951",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "F11" ],
    "parents" : [ 158390 ],
    "children" : [ ]
  }, {
    "dbId" : 9673213,
    "stId" : "R-HSA-9673213",
    "displayName" : "F9(29-461) R43W [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P00740",
    "standardIdentifier" : "uniprot:P00740",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "F9" ],
    "parents" : [ 9673225 ],
    "children" : [ ]
  }, {
    "dbId" : 9673404,
    "stId" : "R-HSA-9673404",
    "displayName" : "12xCbxE-3D-F9(47-461) R191H [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P00740",
    "standardIdentifier" : "uniprot:P00740",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "F9" ],
    "parents" : [ 9673225 ],
    "children" : [ ]
  }, {
    "dbId" : 158130,
    "stId" : "R-HSA-158130",
    "displayName" : "factor XIa:GPIb:GPIX:GPV complex [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 1058 ],
    "parents" : [ ],
    "children" : [ 114668, 158390 ]
  }, {
    "dbId" : 158390,
    "stId" : "R-HSA-158390",
    "displayName" : "factor XIa [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 158130 ],
    "children" : [ 158124, 158263 ]
  }, {
    "dbId" : 9673415,
    "stId" : "R-HSA-9673415",
    "displayName" : "12xCbxE-3D-F9(47-461) R226Q [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P00740",
    "standardIdentifier" : "uniprot:P00740",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "F9" ],
    "parents" : [ 9673225 ],
    "children" : [ ]
  }, {
    "dbId" : 158263,
    "stId" : "R-HSA-158263",
    "displayName" : "factor XIa heavy chain [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P03951",
    "standardIdentifier" : "uniprot:P03951",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "F11" ],
    "parents" : [ 158390 ],
    "children" : [ ]
  }, {
    "dbId" : 55861,
    "stId" : "R-HSA-55861",
    "displayName" : "GP1BA [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P07359",
    "standardIdentifier" : "uniprot:P07359",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GP1BA" ],
    "parents" : [ 114667 ],
    "children" : [ ]
  }, {
    "dbId" : 55863,
    "stId" : "R-HSA-55863",
    "displayName" : "GP1BB [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P13224",
    "standardIdentifier" : "uniprot:P13224",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GP1BB" ],
    "parents" : [ 114667 ],
    "children" : [ ]
  }, {
    "dbId" : 9673418,
    "stId" : "R-HSA-9673418",
    "displayName" : "12xCbxE-3D-F9(47-461) R226G [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P00740",
    "standardIdentifier" : "uniprot:P00740",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "F9" ],
    "parents" : [ 9673225 ],
    "children" : [ ]
  }, {
    "dbId" : 9673225,
    "stId" : "R-HSA-9673225",
    "displayName" : "F9 zymogen variant [extracellular region]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48887,
    "diagramIds" : [ 190296 ],
    "parents" : [ ],
    "children" : [ 9673404, 9673228, 9673213, 9673391, 9673193, 9673403, 9673205, 9673415, 9673418 ]
  }, {
    "dbId" : 9673193,
    "stId" : "R-HSA-9673193",
    "displayName" : "F9(29-461) R46S [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P00740",
    "standardIdentifier" : "uniprot:P00740",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "F9" ],
    "parents" : [ 9673225 ],
    "children" : [ ]
  }, {
    "dbId" : 55899,
    "stId" : "R-HSA-55899",
    "displayName" : "GP5 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P40197",
    "standardIdentifier" : "uniprot:P40197",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "GP5" ],
    "parents" : [ 114668 ],
    "children" : [ ]
  }, {
    "dbId" : 9673391,
    "stId" : "R-HSA-9673391",
    "displayName" : "12xCbxE-3D-F9(47-461) R191C [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P00740",
    "standardIdentifier" : "uniprot:P00740",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "F9" ],
    "parents" : [ 9673225 ],
    "children" : [ ]
  }, {
    "dbId" : 9769739,
    "stId" : "R-HSA-9769739",
    "displayName" : "Regulation of clotting cascade",
    "schemaClass" : "Pathway",
    "speciesId" : 48887,
    "diagramIds" : [ 1835 ]
  }, {
    "dbId" : 9673228,
    "stId" : "R-HSA-9673228",
    "displayName" : "F9(29-461) R43Q [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P00740",
    "standardIdentifier" : "uniprot:P00740",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "F9" ],
    "parents" : [ 9673225 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 9673223,
    "stId" : "R-HSA-9673223",
    "displayName" : "FIX(29-461) variant is not activated (factor XIa catalyst)",
    "schemaClass" : "FailedReaction",
    "speciesId" : 0,
    "inputs" : [ 9673225 ],
    "catalysts" : [ 158130 ],
    "efs" : [ 9673225 ],
    "activators" : [ 74112 ],
    "diagramIds" : [ 190295 ],
    "entityFunctionalStatus" : [ 9673225 ]
  } ]
}