{
  "dbId" : 9614085,
  "stId" : "R-HSA-9614085",
  "speciesName" : "Homo sapiens",
  "nodes" : [ {
    "dbId" : 9614995,
    "stId" : "R-HSA-9614995",
    "displayName" : "p-T26,S184-FOXO6 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "A8MYZ6",
    "standardIdentifier" : "uniprot:A8MYZ6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO6" ],
    "parents" : [ 9614997 ],
    "children" : [ ]
  }, {
    "dbId" : 9617680,
    "stId" : "R-HSA-9617680",
    "displayName" : "CREBBP-S-S-FOXO4:FOXO4-S-S-CREBBP [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 9617678 ],
    "children" : [ 9617679, 9617684 ]
  }, {
    "dbId" : 9617681,
    "stId" : "R-HSA-9617681",
    "displayName" : "EP300-S-S-FOXO4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P98177",
    "standardIdentifier" : "uniprot:P98177",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO4", "AFX", "AFX1", "MLLT7" ],
    "parents" : [ 9617686 ],
    "children" : [ ]
  }, {
    "dbId" : 9617686,
    "stId" : "R-HSA-9617686",
    "displayName" : "EP300-S-S-FOXO4:FOXO4-S-S-EP300 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 451 ],
    "parents" : [ 9617678 ],
    "children" : [ 9617691, 9617681 ]
  }, {
    "dbId" : 427523,
    "stId" : "R-ALL-427523",
    "displayName" : "NAD+ [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 1236, 666 ],
    "identifier" : "57540",
    "standardIdentifier" : "chebi:57540",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9617684,
    "stId" : "R-HSA-9617684",
    "displayName" : "FOXO4-S-S-CREBBP [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q92793",
    "standardIdentifier" : "uniprot:Q92793",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CREBBP", "CBP" ],
    "parents" : [ 9617680 ],
    "children" : [ ]
  }, {
    "dbId" : 199300,
    "stId" : "R-HSA-199300",
    "displayName" : "FOXO1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 1133 ],
    "identifier" : "Q12778",
    "standardIdentifier" : "uniprot:Q12778",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO1", "FKHR", "FOXO1A" ],
    "parents" : [ 9626931, 199272 ],
    "children" : [ ]
  }, {
    "dbId" : 9614997,
    "stId" : "R-HSA-9614997",
    "displayName" : "p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48887,
    "diagramIds" : [ 287 ],
    "parents" : [ ],
    "children" : [ 199289, 199306, 199314, 9614995 ]
  }, {
    "dbId" : 381325,
    "stId" : "R-HSA-381325",
    "displayName" : "EP300 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 453 ],
    "identifier" : "Q09472",
    "standardIdentifier" : "uniprot:Q09472",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "EP300", "P300" ],
    "parents" : [ 1027362, 9620507 ],
    "children" : [ ]
  }, {
    "dbId" : 199306,
    "stId" : "R-HSA-199306",
    "displayName" : "p-T24,S256,S319-FOXO1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q12778",
    "standardIdentifier" : "uniprot:Q12778",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO1", "FKHR", "FOXO1A" ],
    "parents" : [ 199269, 9614997 ],
    "children" : [ ]
  }, {
    "dbId" : 9617691,
    "stId" : "R-HSA-9617691",
    "displayName" : "FOXO4-S-S-EP300 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q09472",
    "standardIdentifier" : "uniprot:Q09472",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "EP300", "P300" ],
    "parents" : [ 9617686 ],
    "children" : [ ]
  }, {
    "dbId" : 9620507,
    "stId" : "R-HSA-9620507",
    "displayName" : "KAT2B,(EP300) [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48887,
    "diagramIds" : [ 622 ],
    "parents" : [ ],
    "children" : [ 352430, 381325 ]
  }, {
    "dbId" : 199305,
    "stId" : "R-HSA-199305",
    "displayName" : "FOXO3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 618 ],
    "identifier" : "O43524",
    "standardIdentifier" : "uniprot:O43524",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO3", "FKHRL1", "FOXO3A" ],
    "parents" : [ 199272 ],
    "children" : [ ]
  }, {
    "dbId" : 193545,
    "stId" : "R-HSA-193545",
    "displayName" : "CREBBP [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 1131 ],
    "identifier" : "Q92793",
    "standardIdentifier" : "uniprot:Q92793",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CREBBP", "CBP" ],
    "parents" : [ 9626931, 1027362 ],
    "children" : [ ]
  }, {
    "dbId" : 427531,
    "stId" : "R-HSA-427531",
    "displayName" : "SIRT1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 1233 ],
    "identifier" : "Q96EB6",
    "standardIdentifier" : "uniprot:Q96EB6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SIRT1", "SIR2L1" ],
    "parents" : [ 9622899 ],
    "children" : [ ]
  }, {
    "dbId" : 206099,
    "stId" : "R-HSA-206099",
    "displayName" : "YWHAZ [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P63104",
    "standardIdentifier" : "uniprot:P63104",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "YWHAZ" ],
    "parents" : [ 206751 ],
    "children" : [ ]
  }, {
    "dbId" : 5690183,
    "stId" : "R-HSA-5690183",
    "displayName" : "FOXO4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 180 ],
    "identifier" : "P98177",
    "standardIdentifier" : "uniprot:P98177",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO4", "AFX", "AFX1", "MLLT7" ],
    "parents" : [ 199272 ],
    "children" : [ ]
  }, {
    "dbId" : 199314,
    "stId" : "R-HSA-199314",
    "displayName" : "p-T32,S197,S262-FOXO4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P98177",
    "standardIdentifier" : "uniprot:P98177",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO4", "AFX", "AFX1", "MLLT7" ],
    "parents" : [ 199269, 9614997 ],
    "children" : [ ]
  }, {
    "dbId" : 1257604,
    "stId" : "R-HSA-1257604",
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 48887,
    "diagramIds" : [ 16 ]
  }, {
    "dbId" : 2262714,
    "stId" : "R-HSA-2262714",
    "displayName" : "YWHAQ dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 9614573, 9614627 ],
    "children" : [ 1445116 ]
  }, {
    "dbId" : 113560,
    "stId" : "R-ALL-113560",
    "displayName" : "Ac-CoA [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 640, 489 ],
    "identifier" : "57288",
    "standardIdentifier" : "chebi:57288",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 2262713,
    "stId" : "R-HSA-2262713",
    "displayName" : "YWHAG dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 9614573 ],
    "children" : [ 380312 ]
  }, {
    "dbId" : 206751,
    "stId" : "R-HSA-206751",
    "displayName" : "YWHAZ dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 117 ],
    "parents" : [ 9614653, 9614573, 9614627 ],
    "children" : [ 206099 ]
  }, {
    "dbId" : 9617678,
    "stId" : "R-HSA-9617678",
    "displayName" : "CREBPP-S-S-FOXO4:FOXO4-S-S-CREBBP,EP300-S-S-FOXO4:FOXO4-S-S-EP300 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "diagramIds" : [ 383 ],
    "parents" : [ ],
    "children" : [ 9617686, 9617680 ]
  }, {
    "dbId" : 380312,
    "stId" : "R-HSA-380312",
    "displayName" : "YWHAG [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P61981",
    "standardIdentifier" : "uniprot:P61981",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "YWHAG" ],
    "parents" : [ 2262713 ],
    "children" : [ ]
  }, {
    "dbId" : 9617679,
    "stId" : "R-HSA-9617679",
    "displayName" : "CREBBP-S-S-FOXO4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P98177",
    "standardIdentifier" : "uniprot:P98177",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO4", "AFX", "AFX1", "MLLT7" ],
    "parents" : [ 9617680 ],
    "children" : [ ]
  }, {
    "dbId" : 2262716,
    "stId" : "R-HSA-2262716",
    "displayName" : "SFN dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 9614627 ],
    "children" : [ 1445105 ]
  }, {
    "dbId" : 9626931,
    "stId" : "R-HSA-9626931",
    "displayName" : "FOXO1:CREBBP [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 1136 ],
    "parents" : [ ],
    "children" : [ 193545, 199300 ]
  }, {
    "dbId" : 352430,
    "stId" : "R-HSA-352430",
    "displayName" : "KAT2B [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q92831",
    "standardIdentifier" : "uniprot:Q92831",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "KAT2B", "PCAF" ],
    "parents" : [ 9620507 ],
    "children" : [ ]
  }, {
    "dbId" : 9626942,
    "stId" : "R-HSA-9626942",
    "displayName" : "Ac-K245,K248,K265-FOXO1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 1192 ],
    "identifier" : "Q12778",
    "standardIdentifier" : "uniprot:Q12778",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO1", "FKHR", "FOXO1A" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 1027362,
    "stId" : "R-HSA-1027362",
    "displayName" : "CREBBP,EP300 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "diagramIds" : [ 382 ],
    "parents" : [ ],
    "children" : [ 381325, 193545 ]
  }, {
    "dbId" : 9614396,
    "stId" : "R-HSA-9614396",
    "displayName" : "FOXO6 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "A8MYZ6",
    "standardIdentifier" : "uniprot:A8MYZ6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO6" ],
    "parents" : [ 199272 ],
    "children" : [ ]
  }, {
    "dbId" : 29358,
    "stId" : "R-ALL-29358",
    "displayName" : "ATP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 12 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113582,
    "stId" : "R-ALL-113582",
    "displayName" : "ADP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 289 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9614653,
    "stId" : "R-HSA-9614653",
    "displayName" : "p-T32,S197,S262-FOXO4:YWHAZ dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 120 ],
    "parents" : [ ],
    "children" : [ 9614415, 206751 ]
  }, {
    "dbId" : 2485002,
    "stId" : "R-ALL-2485002",
    "displayName" : "CoA-SH [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 642, 490 ],
    "identifier" : "57287",
    "standardIdentifier" : "chebi:57287",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9620514,
    "stId" : "R-HSA-9620514",
    "displayName" : "Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 621 ],
    "identifier" : "O43524",
    "standardIdentifier" : "uniprot:O43524",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO3", "FKHRL1", "FOXO3A" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9614627,
    "stId" : "R-HSA-9614627",
    "displayName" : "YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "diagramIds" : [ 103 ],
    "parents" : [ 9614628 ],
    "children" : [ 2262716, 206751, 2262714 ]
  }, {
    "dbId" : 9617828,
    "stId" : "R-HSA-9617828",
    "displayName" : "FOXO-mediated transcription of cell cycle genes",
    "schemaClass" : "Pathway",
    "speciesId" : 48887,
    "diagramIds" : [ 599 ]
  }, {
    "dbId" : 9614628,
    "stId" : "R-HSA-9614628",
    "displayName" : "p-T32,S253,S315-FOXO3:YWHAZ,YWHAQ,SFN [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 107 ],
    "parents" : [ ],
    "children" : [ 9614413, 9614627 ]
  }, {
    "dbId" : 9615017,
    "stId" : "R-HSA-9615017",
    "displayName" : "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes",
    "schemaClass" : "Pathway",
    "speciesId" : 48887,
    "diagramIds" : [ 596 ]
  }, {
    "dbId" : 9617747,
    "stId" : "R-HSA-9617747",
    "displayName" : "TXNIP [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 469 ],
    "identifier" : "Q9H3M7",
    "standardIdentifier" : "uniprot:Q9H3M7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TXNIP", "VDUP1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9614416,
    "stId" : "R-HSA-9614416",
    "displayName" : "p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "diagramIds" : [ 58 ],
    "parents" : [ ],
    "children" : [ 9614413, 9614415, 211158 ]
  }, {
    "dbId" : 9622879,
    "stId" : "R-HSA-9622879",
    "displayName" : "SIRT3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q9NTG7",
    "standardIdentifier" : "uniprot:Q9NTG7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SIRT3", "SIR2L3" ],
    "parents" : [ 9622899 ],
    "children" : [ ]
  }, {
    "dbId" : 3785707,
    "stId" : "R-ALL-3785707",
    "displayName" : "ROS [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 325 ],
    "identifier" : "26523",
    "standardIdentifier" : "chebi:26523",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9614657,
    "stId" : "R-HSA-9614657",
    "displayName" : "FOXO-mediated transcription of cell death genes",
    "schemaClass" : "Pathway",
    "speciesId" : 48887,
    "diagramIds" : [ 680 ]
  }, {
    "dbId" : 211158,
    "stId" : "R-HSA-211158",
    "displayName" : "p-T24,S256,S319-FOXO1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 87 ],
    "identifier" : "Q12778",
    "standardIdentifier" : "uniprot:Q12778",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO1", "FKHR", "FOXO1A" ],
    "parents" : [ 9614572, 9614416 ],
    "children" : [ ]
  }, {
    "dbId" : 198357,
    "stId" : "R-HSA-198357",
    "displayName" : "p-T308,S473-AKT1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P31749",
    "standardIdentifier" : "uniprot:P31749",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "AKT1", "PKB", "RAC" ],
    "parents" : [ 202072 ],
    "children" : [ ]
  }, {
    "dbId" : 9617732,
    "stId" : "R-HSA-9617732",
    "displayName" : "TXN [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 441 ],
    "identifier" : "P10599",
    "standardIdentifier" : "uniprot:P10599",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TXN", "TRDX", "TRX", "TRX1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9617733,
    "stId" : "R-HSA-9617733",
    "displayName" : "2xHC-TXN [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 442 ],
    "identifier" : "P10599",
    "standardIdentifier" : "uniprot:P10599",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TXN", "TRDX", "TRX", "TRX1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 202072,
    "stId" : "R-HSA-202072",
    "displayName" : "p-T,p-S-AKT [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48887,
    "diagramIds" : [ 15 ],
    "parents" : [ ],
    "children" : [ 198357, 3009365, 202087 ]
  }, {
    "dbId" : 9614415,
    "stId" : "R-HSA-9614415",
    "displayName" : "p-T32,S197,S262-FOXO4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 115 ],
    "identifier" : "P98177",
    "standardIdentifier" : "uniprot:P98177",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO4", "AFX", "AFX1", "MLLT7" ],
    "parents" : [ 9614653, 9614416 ],
    "children" : [ ]
  }, {
    "dbId" : 9614413,
    "stId" : "R-HSA-9614413",
    "displayName" : "p-T32,S253,S315-FOXO3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 105 ],
    "identifier" : "O43524",
    "standardIdentifier" : "uniprot:O43524",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO3", "FKHRL1", "FOXO3A" ],
    "parents" : [ 9614416, 9614628 ],
    "children" : [ ]
  }, {
    "dbId" : 9622899,
    "stId" : "R-HSA-9622899",
    "displayName" : "SIRT1,SIRT3 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "diagramIds" : [ 1104 ],
    "parents" : [ ],
    "children" : [ 9622879, 427531 ]
  }, {
    "dbId" : 202087,
    "stId" : "R-HSA-202087",
    "displayName" : "p-T309,S474-AKT2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P31751",
    "standardIdentifier" : "uniprot:P31751",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "AKT2" ],
    "parents" : [ 202072 ],
    "children" : [ ]
  }, {
    "dbId" : 9617655,
    "stId" : "R-HSA-9617655",
    "displayName" : "SOH-C481-FOXO4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 326 ],
    "identifier" : "P98177",
    "standardIdentifier" : "uniprot:P98177",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO4", "AFX", "AFX1", "MLLT7" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 199269,
    "stId" : "R-HSA-199269",
    "displayName" : "p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "diagramIds" : [ 13 ],
    "parents" : [ ],
    "children" : [ 199289, 199306, 199314 ]
  }, {
    "dbId" : 1445105,
    "stId" : "R-HSA-1445105",
    "displayName" : "SFN [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P31947",
    "standardIdentifier" : "uniprot:P31947",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SFN", "HME1" ],
    "parents" : [ 2262716 ],
    "children" : [ ]
  }, {
    "dbId" : 1445116,
    "stId" : "R-HSA-1445116",
    "displayName" : "YWHAQ [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P27348",
    "standardIdentifier" : "uniprot:P27348",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "YWHAQ" ],
    "parents" : [ 2262714 ],
    "children" : [ ]
  }, {
    "dbId" : 199272,
    "stId" : "R-HSA-199272",
    "displayName" : "FOXO1,FOXO3,FOXO4,(FOXO6) [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48887,
    "diagramIds" : [ 282 ],
    "parents" : [ ],
    "children" : [ 199305, 199300, 5690183, 9614396 ]
  }, {
    "dbId" : 427498,
    "stId" : "R-ALL-427498",
    "displayName" : "2'-O-acetyl-ADP-ribose [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 1240, 667 ],
    "identifier" : "83767",
    "standardIdentifier" : "chebi:83767",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 427497,
    "stId" : "R-ALL-427497",
    "displayName" : "NAM [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 1238, 668 ],
    "identifier" : "17154",
    "standardIdentifier" : "chebi:17154",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9617761,
    "stId" : "R-HSA-9617761",
    "displayName" : "Ac-K-FOXO4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 491 ],
    "identifier" : "P98177",
    "standardIdentifier" : "uniprot:P98177",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO4", "AFX", "AFX1", "MLLT7" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 3009365,
    "stId" : "R-HSA-3009365",
    "displayName" : "p-T305,S472-AKT3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q9Y243",
    "standardIdentifier" : "uniprot:Q9Y243",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "AKT3", "PKBG" ],
    "parents" : [ 202072 ],
    "children" : [ ]
  }, {
    "dbId" : 48888,
    "stId" : "R-HSA-48888",
    "displayName" : "YWHAB [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P31946",
    "standardIdentifier" : "uniprot:P31946",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "YWHAB" ],
    "parents" : [ 2028645 ],
    "children" : [ ]
  }, {
    "dbId" : 199289,
    "stId" : "R-HSA-199289",
    "displayName" : "p-T32,S253,S315-FOXO3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "O43524",
    "standardIdentifier" : "uniprot:O43524",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "FOXO3", "FKHRL1", "FOXO3A" ],
    "parents" : [ 199269, 9614997 ],
    "children" : [ ]
  }, {
    "dbId" : 2028645,
    "stId" : "R-HSA-2028645",
    "displayName" : "YWHAB dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 9614573 ],
    "children" : [ 48888 ]
  }, {
    "dbId" : 9614572,
    "stId" : "R-HSA-9614572",
    "displayName" : "p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 90 ],
    "parents" : [ ],
    "children" : [ 9614573, 211158 ]
  }, {
    "dbId" : 9614573,
    "stId" : "R-HSA-9614573",
    "displayName" : "YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "diagramIds" : [ 89 ],
    "parents" : [ 9614572 ],
    "children" : [ 206751, 2028645, 2262713, 2262714 ]
  } ],
  "edges" : [ {
    "dbId" : 199299,
    "stId" : "R-HSA-199299",
    "displayName" : "AKT phosphorylates FOXO transcription factors",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 9614414 ],
    "inputs" : [ 29358, 199272 ],
    "outputs" : [ 113582, 9614997 ],
    "catalysts" : [ 202072 ],
    "efs" : [ ],
    "diagramIds" : [ 10 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9626962,
    "stId" : "R-HSA-9626962",
    "displayName" : "SIRT1 deacetylates FOXO1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 9626942, 427523 ],
    "outputs" : [ 427497, 427498, 199300 ],
    "catalysts" : [ 427531 ],
    "efs" : [ ],
    "diagramIds" : [ 1232 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9617683,
    "stId" : "R-HSA-9617683",
    "displayName" : "EP300,CREBBP bind SOH-C481-FOXO4",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9617660 ],
    "following" : [ 9617735 ],
    "inputs" : [ 1027362, 9617655 ],
    "outputs" : [ 9617678 ],
    "efs" : [ ],
    "diagramIds" : [ 381 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9626928,
    "stId" : "R-HSA-9626928",
    "displayName" : "CREBBP binds FOXO1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 193545, 199300 ],
    "outputs" : [ 9626931 ],
    "efs" : [ ],
    "diagramIds" : [ 1130 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9614423,
    "stId" : "R-HSA-9614423",
    "displayName" : "14-3-3 proteins bind AKT-phosphorylated FOXO1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9614414 ],
    "inputs" : [ 9614573, 211158 ],
    "outputs" : [ 9614572 ],
    "efs" : [ ],
    "diagramIds" : [ 86 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9620532,
    "stId" : "R-HSA-9620532",
    "displayName" : "SIRT1,SIRT3 deacetylate FOXO3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9620515 ],
    "inputs" : [ 427523, 9620514 ],
    "outputs" : [ 427497, 427498, 199305 ],
    "catalysts" : [ 9622899 ],
    "efs" : [ ],
    "diagramIds" : [ 665 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9617758,
    "stId" : "R-HSA-9617758",
    "displayName" : "EP300,CREBBP acetylate FOXO4",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 9617678, 113560 ],
    "outputs" : [ 2485002, 1027362, 9617761 ],
    "catalysts" : [ 9617678 ],
    "efs" : [ ],
    "diagramIds" : [ 488 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9617660,
    "stId" : "R-HSA-9617660",
    "displayName" : "ROS oxidize FOXO4 cysteine residues",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 9617683 ],
    "inputs" : [ 3785707, 5690183 ],
    "outputs" : [ 9617655 ],
    "efs" : [ ],
    "diagramIds" : [ 324 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9614562,
    "stId" : "R-HSA-9614562",
    "displayName" : "14-3-3 proteins bind AKT-phosphorylated FOXO3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9614414 ],
    "inputs" : [ 9614413, 9614627 ],
    "outputs" : [ 9614628 ],
    "efs" : [ ],
    "diagramIds" : [ 102 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9620515,
    "stId" : "R-HSA-9620515",
    "displayName" : "KAT2B,EP300 acetylate FOXO3 under oxidative stress",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 9620532 ],
    "inputs" : [ 199305, 113560 ],
    "outputs" : [ 2485002, 9620514 ],
    "catalysts" : [ 9620507 ],
    "efs" : [ ],
    "activators" : [ 3785707 ],
    "diagramIds" : [ 617 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9626945,
    "stId" : "R-HSA-9626945",
    "displayName" : "CREBBP acetylates FOXO1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 113560, 9626931 ],
    "outputs" : [ 2485002, 9626942, 193545 ],
    "catalysts" : [ 9626931 ],
    "efs" : [ ],
    "diagramIds" : [ 1191 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9617735,
    "stId" : "R-HSA-9617735",
    "displayName" : "TXN disrupts FOXO4 complex with EP300",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9617683 ],
    "inputs" : [ 9617732, 9617686 ],
    "outputs" : [ 381325, 9617733, 5690183 ],
    "catalysts" : [ 9617732 ],
    "efs" : [ ],
    "inhibitors" : [ 9617747 ],
    "diagramIds" : [ 440 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9614564,
    "stId" : "R-HSA-9614564",
    "displayName" : "14-3-3 proteins bind AKT-phosphorylated FOXO4",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 9614414 ],
    "inputs" : [ 9614415, 206751 ],
    "outputs" : [ 9614653 ],
    "efs" : [ ],
    "diagramIds" : [ 114 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 9614414,
    "stId" : "R-HSA-9614414",
    "displayName" : "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 199299 ],
    "following" : [ 9614564, 9614423, 9614562 ],
    "inputs" : [ 199269 ],
    "outputs" : [ 9614416 ],
    "efs" : [ ],
    "diagramIds" : [ 57 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 9614399,
    "stId" : "R-HSA-9614399",
    "displayName" : "Regulation of localization of FOXO transcription factors",
    "events" : [ 199299, 9614562, 9614423, 9614564, 9614414 ]
  }, {
    "dbId" : 9617629,
    "stId" : "R-HSA-9617629",
    "displayName" : "Regulation of FOXO transcriptional activity by acetylation",
    "events" : [ 9626962, 9617683, 9620515, 9626928, 9626945, 9617735, 9620532, 9617758, 9617660 ]
  } ]
}