{ "dbId" : 8939902, "stableId" : "R-HSA-8939902", "displayName" : "Regulation of RUNX2 expression and activity", "nodes" : [ { "id" : 132, "reactomeId" : 9007760, "displayName" : "MSX2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 618, "y" : 842 }, "minX" : 597, "maxX" : 652, "minY" : 749, "maxY" : 853, "prop" : { "x" : 597, "y" : 831, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 597, "y" : 831 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 639, "y" : 831 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 639, "y" : 831 } } }, "connectors" : [ { "edgeId" : 131, "type" : "INPUT", "segments" : [ { "from" : { "x" : 622, "y" : 828 }, "to" : { "x" : 652, "y" : 749 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 133, "reactomeId" : 9007758, "displayName" : "MSX2:RUNX2 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 992, "y" : 639 }, "minX" : 890, "maxX" : 1040, "minY" : 481, "maxY" : 657, "prop" : { "x" : 951, "y" : 621, "width" : 83, "height" : 36 }, "textPosition" : { "x" : 966, "y" : 608 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1034, "y" : 621 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1034, "y" : 621 } } }, "connectors" : [ { "edgeId" : 131, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 47, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 980, "y" : 618 }, "to" : { "x" : 893, "y" : 483 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 890, "y" : 485 }, "b" : { "x" : 896, "y" : 481 }, "c" : { "x" : 893, "y" : 483 }, "type" : "STOP", "centre" : { "x" : 893, "y" : 483 } } } ] }, { "id" : 6, "reactomeId" : 1254381, "displayName" : "ESR1 dimer:ESTG", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 439, "y" : 297 }, "minX" : 392, "maxX" : 542, "minY" : 279, "maxY" : 310, "prop" : { "x" : 392, "y" : 285, "width" : 95, "height" : 25 }, "textPosition" : { "x" : 398, "y" : 275 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 487, "y" : 285 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 487, "y" : 285 } } }, "connectors" : [ { "edgeId" : 5, "type" : "INPUT", "segments" : [ { "from" : { "x" : 490, "y" : 292 }, "to" : { "x" : 542, "y" : 287 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 7, "reactomeId" : 8939903, "displayName" : "RUNX2 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 559, "y" : 464 }, "minX" : 533, "maxX" : 675, "minY" : 162, "maxY" : 749, "prop" : { "x" : 533, "y" : 432, "width" : 53, "height" : 65 }, "textPosition" : { "x" : 533, "y" : 459 }, "connectors" : [ { "edgeId" : 65, "type" : "INPUT", "segments" : [ { "from" : { "x" : 595, "y" : 434 }, "to" : { "x" : 675, "y" : 698 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 131, "type" : "INPUT", "segments" : [ { "from" : { "x" : 595, "y" : 434 }, "to" : { "x" : 652, "y" : 749 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 5, "type" : "INPUT", "segments" : [ { "from" : { "x" : 595, "y" : 434 }, "to" : { "x" : 542, "y" : 287 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 9, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 396, "type" : "INPUT", "segments" : [ { "from" : { "x" : 595, "y" : 434 }, "to" : { "x" : 641, "y" : 492 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 975, "type" : "INPUT", "segments" : [ { "from" : { "x" : 595, "y" : 434 }, "to" : { "x" : 616, "y" : 295 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 15, "type" : "INPUT", "segments" : [ { "from" : { "x" : 595, "y" : 434 }, "to" : { "x" : 550, "y" : 238 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 17, "type" : "INPUT", "segments" : [ { "from" : { "x" : 595, "y" : 434 }, "to" : { "x" : 562, "y" : 198 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 466, "type" : "INPUT", "segments" : [ { "from" : { "x" : 595, "y" : 434 }, "to" : { "x" : 620, "y" : 362 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 19, "type" : "INPUT", "segments" : [ { "from" : { "x" : 595, "y" : 434 }, "to" : { "x" : 579, "y" : 162 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 27, "type" : "INPUT", "segments" : [ { "from" : { "x" : 595, "y" : 434 }, "to" : { "x" : 608, "y" : 627 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 47, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 593, "y" : 430 }, "b" : { "x" : 586, "y" : 434 }, "c" : { "x" : 593, "y" : 438 }, "type" : "ARROW", "centre" : { "x" : 593, "y" : 438 } } }, { "id" : 8, "reactomeId" : 8939910, "displayName" : "ESR1:estrogen:RUNX2 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 824, "y" : 271 }, "minX" : 777, "maxX" : 878, "minY" : 248, "maxY" : 389, "prop" : { "x" : 777, "y" : 254, "width" : 95, "height" : 35 }, "textPosition" : { "x" : 782, "y" : 240 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 872, "y" : 254 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 872, "y" : 254 } } }, "connectors" : [ { "edgeId" : 5, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 9, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 827, "y" : 292 }, "to" : { "x" : 846, "y" : 389 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 841, "y" : 383 }, "b" : { "x" : 846, "y" : 389 }, "c" : { "x" : 849, "y" : 381 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 849, "y" : 381 } } } ] }, { "id" : 136, "reactomeId" : 9007779, "displayName" : "DLX5,(DLX6)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 595, "y" : 697 }, "minX" : 571, "maxX" : 675, "minY" : 677, "maxY" : 717, "prop" : { "x" : 571, "y" : 677, "width" : 49, "height" : 40 }, "textPosition" : { "x" : 571, "y" : 679 }, "connectors" : [ { "edgeId" : 65, "type" : "INPUT", "segments" : [ { "from" : { "x" : 626, "y" : 697 }, "to" : { "x" : 675, "y" : 698 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 521, "reactomeId" : 975972, "displayName" : "SMURF1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1552, "y" : 564 }, "minX" : 1522, "maxX" : 1808, "minY" : 500, "maxY" : 680, "prop" : { "x" : 1522, "y" : 552, "width" : 60, "height" : 24 }, "textPosition" : { "x" : 1523, "y" : 553 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1582, "y" : 552 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1582, "y" : 552 } } }, "connectors" : [ { "edgeId" : 520, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1554, "y" : 549 }, "to" : { "x" : 1567, "y" : 500 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 523, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1555, "y" : 579 }, "to" : { "x" : 1590, "y" : 679 } }, { "from" : { "x" : 1590, "y" : 679 }, "to" : { "x" : 1805, "y" : 680 } }, { "from" : { "x" : 1805, "y" : 680 }, "to" : { "x" : 1808, "y" : 573 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1561, "y" : 584 }, "b" : { "x" : 1555, "y" : 579 }, "c" : { "x" : 1554, "y" : 587 }, "type" : "ARROW", "centre" : { "x" : 1554, "y" : 587 } } }, { "edgeId" : 571, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 522, "reactomeId" : 9009416, "displayName" : "RUNX2:SMURF1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1715, "y" : 640 }, "minX" : 1680, "maxX" : 1766, "minY" : 574, "maxY" : 658, "prop" : { "x" : 1680, "y" : 623, "width" : 71, "height" : 35 }, "textPosition" : { "x" : 1686, "y" : 623 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1751, "y" : 623 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1751, "y" : 623 } } }, "connectors" : [ { "edgeId" : 520, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 523, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1714, "y" : 620 }, "to" : { "x" : 1714, "y" : 574 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 523, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1734, "y" : 620 }, "to" : { "x" : 1754, "y" : 605 } }, { "from" : { "x" : 1754, "y" : 605 }, "to" : { "x" : 1761, "y" : 587 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1762, "y" : 583 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1762, "y" : 583 } } } ] }, { "id" : 11, "reactomeId" : 8940046, "displayName" : "TWIST1:RUNX2 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1164, "y" : 131 }, "minX" : 855, "maxX" : 1214, "minY" : 109, "maxY" : 392, "prop" : { "x" : 1121, "y" : 115, "width" : 87, "height" : 33 }, "textPosition" : { "x" : 1122, "y" : 113 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1208, "y" : 115 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1208, "y" : 115 } } }, "connectors" : [ { "edgeId" : 9, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1144, "y" : 151 }, "to" : { "x" : 855, "y" : 392 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 858, "y" : 384 }, "b" : { "x" : 855, "y" : 392 }, "c" : { "x" : 863, "y" : 391 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 863, "y" : 391 } } }, { "edgeId" : 19, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 12, "reactomeId" : 8939930, "displayName" : "ESRRA:PPARG1CA:RUNX2 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 906, "y" : 211 }, "minX" : 843, "maxX" : 976, "minY" : 186, "maxY" : 389, "prop" : { "x" : 843, "y" : 192, "width" : 127, "height" : 38 }, "textPosition" : { "x" : 846, "y" : 195 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 970, "y" : 192 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 970, "y" : 192 } } }, "connectors" : [ { "edgeId" : 9, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 900, "y" : 233 }, "to" : { "x" : 851, "y" : 389 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 849, "y" : 381 }, "b" : { "x" : 851, "y" : 389 }, "c" : { "x" : 857, "y" : 384 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 857, "y" : 384 } } }, { "edgeId" : 15, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 397, "reactomeId" : 8865420, "displayName" : "RUNX2:CBFB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 974, "y" : 539 }, "minX" : 946, "maxX" : 1030, "minY" : 515, "maxY" : 557, "prop" : { "x" : 946, "y" : 521, "width" : 57, "height" : 36 }, "textPosition" : { "x" : 948, "y" : 522 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1003, "y" : 521 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1003, "y" : 521 } } }, "connectors" : [ { "edgeId" : 554, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1006, "y" : 547 }, "to" : { "x" : 1030, "y" : 556 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13, "reactomeId" : 8939943, "displayName" : "ESRRA:PPARG1CB:RUNX2 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1035, "y" : 169 }, "minX" : 851, "maxX" : 1099, "minY" : 143, "maxY" : 394, "prop" : { "x" : 978, "y" : 149, "width" : 115, "height" : 41 }, "textPosition" : { "x" : 993, "y" : 141 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1093, "y" : 149 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1093, "y" : 149 } } }, "connectors" : [ { "edgeId" : 9, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1018, "y" : 193 }, "to" : { "x" : 854, "y" : 391 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 851, "y" : 388 }, "b" : { "x" : 857, "y" : 394 }, "c" : { "x" : 854, "y" : 391 }, "type" : "STOP", "centre" : { "x" : 854, "y" : 391 } } }, { "edgeId" : 17, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 14, "reactomeId" : 8985291, "displayName" : "NKX3-2:RUNX2 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 807, "y" : 642 }, "minX" : 762, "maxX" : 888, "minY" : 481, "maxY" : 660, "prop" : { "x" : 762, "y" : 624, "width" : 90, "height" : 36 }, "textPosition" : { "x" : 764, "y" : 625 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 852, "y" : 624 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 852, "y" : 624 } } }, "connectors" : [ { "edgeId" : 27, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 47, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 815, "y" : 621 }, "to" : { "x" : 884, "y" : 483 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 880, "y" : 481 }, "b" : { "x" : 888, "y" : 485 }, "c" : { "x" : 884, "y" : 483 }, "type" : "STOP", "centre" : { "x" : 884, "y" : 483 } } } ] }, { "id" : 398, "reactomeId" : 9008361, "displayName" : "RUNX2-P1:CBFB:RUNX2 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 732, "y" : 581 }, "minX" : 677, "maxX" : 882, "minY" : 477, "maxY" : 600, "prop" : { "x" : 677, "y" : 563, "width" : 110, "height" : 37 }, "textPosition" : { "x" : 678, "y" : 565 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 787, "y" : 563 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 787, "y" : 563 } } }, "connectors" : [ { "edgeId" : 396, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 47, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 759, "y" : 560 }, "to" : { "x" : 880, "y" : 480 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 878, "y" : 477 }, "b" : { "x" : 882, "y" : 483 }, "c" : { "x" : 880, "y" : 480 }, "type" : "STOP", "centre" : { "x" : 880, "y" : 480 } } } ] }, { "id" : 16, "reactomeId" : 8939924, "displayName" : "ESRRA:PPARGC1A", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 429, "y" : 250 }, "minX" : 369, "maxX" : 550, "minY" : 231, "maxY" : 263, "prop" : { "x" : 369, "y" : 237, "width" : 121, "height" : 26 }, "textPosition" : { "x" : 371, "y" : 242 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 490, "y" : 237 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 490, "y" : 237 } } }, "connectors" : [ { "edgeId" : 15, "type" : "INPUT", "segments" : [ { "from" : { "x" : 493, "y" : 244 }, "to" : { "x" : 550, "y" : 238 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 400, "reactomeId" : 2022823, "displayName" : "GSK3B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1035, "y" : 772 }, "minX" : 1009, "maxX" : 1161, "minY" : 725, "maxY" : 784, "prop" : { "x" : 1009, "y" : 761, "width" : 53, "height" : 23 }, "textPosition" : { "x" : 1011, "y" : 762 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1062, "y" : 761 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1062, "y" : 761 } } }, "connectors" : [ { "edgeId" : 399, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1065, "y" : 762 }, "to" : { "x" : 1161, "y" : 725 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 272, "reactomeId" : 9007987, "displayName" : "RUNX2-P2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1303, "y" : 377 }, "minX" : 1267, "maxX" : 1345, "minY" : 360, "maxY" : 388, "prop" : { "x" : 1267, "y" : 366, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 1268, "y" : 366 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1339, "y" : 366 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1339, "y" : 366 } } }, "connectors" : [ { "edgeId" : 9, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 401, "reactomeId" : 9008489, "displayName" : "RUNX2:GSK3B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1176, "y" : 895 }, "minX" : 1146, "maxX" : 1212, "minY" : 870, "maxY" : 970, "prop" : { "x" : 1146, "y" : 876, "width" : 60, "height" : 39 }, "textPosition" : { "x" : 1149, "y" : 880 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1206, "y" : 876 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1206, "y" : 876 } } }, "connectors" : [ { "edgeId" : 399, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 411, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1176, "y" : 918 }, "to" : { "x" : 1176, "y" : 936 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 411, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1189, "y" : 918 }, "to" : { "x" : 1212, "y" : 949 } }, { "from" : { "x" : 1212, "y" : 949 }, "to" : { "x" : 1187, "y" : 964 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1183, "y" : 966 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1183, "y" : 966 } } } ] }, { "id" : 18, "reactomeId" : 8939923, "displayName" : "ESRRA:PPARGC1B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 434, "y" : 195 }, "minX" : 375, "maxX" : 562, "minY" : 176, "maxY" : 208, "prop" : { "x" : 375, "y" : 182, "width" : 119, "height" : 26 }, "textPosition" : { "x" : 376, "y" : 187 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 494, "y" : 182 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 494, "y" : 182 } } }, "connectors" : [ { "edgeId" : 17, "type" : "INPUT", "segments" : [ { "from" : { "x" : 497, "y" : 196 }, "to" : { "x" : 562, "y" : 198 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 275, "reactomeId" : 9007983, "displayName" : "RUNX2-P1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1299, "y" : 502 }, "minX" : 1263, "maxX" : 1341, "minY" : 485, "maxY" : 513, "prop" : { "x" : 1263, "y" : 491, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 1264, "y" : 491 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1335, "y" : 491 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1335, "y" : 491 } } }, "connectors" : [ { "edgeId" : 47, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 20, "reactomeId" : 445442, "displayName" : "TWIST1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 365, "y" : 148 }, "minX" : 340, "maxX" : 579, "minY" : 131, "maxY" : 162, "prop" : { "x" : 340, "y" : 137, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 343, "y" : 131 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 391, "y" : 137 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 391, "y" : 137 } } }, "connectors" : [ { "edgeId" : 19, "type" : "INPUT", "segments" : [ { "from" : { "x" : 394, "y" : 149 }, "to" : { "x" : 579, "y" : 162 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 26, "reactomeId" : 8985289, "displayName" : "NKX3-2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 515, "y" : 714 }, "minX" : 479, "maxX" : 608, "minY" : 627, "maxY" : 725, "prop" : { "x" : 479, "y" : 703, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 490, "y" : 703 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 552, "y" : 703 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 552, "y" : 703 } } }, "connectors" : [ { "edgeId" : 27, "type" : "INPUT", "segments" : [ { "from" : { "x" : 526, "y" : 700 }, "to" : { "x" : 608, "y" : 627 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 283, "reactomeId" : 9007986, "displayName" : "RUNX2", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1449, "y" : 451 }, "minX" : 1424, "maxX" : 1567, "minY" : 337, "maxY" : 515, "prop" : { "x" : 1424, "y" : 440, "width" : 50, "height" : 22 }, "textPosition" : { "x" : 1424, "y" : 440 }, "connectors" : [ { "edgeId" : 324, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1452, "y" : 434 }, "to" : { "x" : 1481, "y" : 337 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 520, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1480, "y" : 461 }, "to" : { "x" : 1567, "y" : 500 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 473, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1480, "y" : 451 }, "to" : { "x" : 1532, "y" : 454 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 282, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1449, "y" : 468 }, "to" : { "x" : 1449, "y" : 515 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 296, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 412, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1105, "y" : 932 }, "minX" : 1087, "maxX" : 1176, "minY" : 918, "maxY" : 945, "prop" : { "x" : 1087, "y" : 919, "width" : 37, "height" : 26 }, "textPosition" : { "x" : 1090, "y" : 921 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1119, "y" : 924 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1119, "y" : 924 } } }, "connectors" : [ { "edgeId" : 411, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1127, "y" : 933 }, "to" : { "x" : 1176, "y" : 936 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1145, "y" : 928 }, "b" : { "x" : 1157, "y" : 940 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1151, "y" : 934 } } } } ] }, { "id" : 413, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1108, "y" : 978 }, "minX" : 1089, "maxX" : 1173, "minY" : 965, "maxY" : 1004, "prop" : { "x" : 1089, "y" : 966, "width" : 39, "height" : 25 }, "textPosition" : { "x" : 1092, "y" : 968 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1123, "y" : 971 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1123, "y" : 971 } } }, "connectors" : [ { "edgeId" : 411, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1131, "y" : 985 }, "to" : { "x" : 1173, "y" : 1004 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1146, "y" : 988 }, "b" : { "x" : 1158, "y" : 1000 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1152, "y" : 994 } } }, "endShape" : { "a" : { "x" : 1139, "y" : 984 }, "b" : { "x" : 1131, "y" : 985 }, "c" : { "x" : 1136, "y" : 992 }, "type" : "ARROW", "centre" : { "x" : 1136, "y" : 992 } } } ] }, { "id" : 414, "reactomeId" : 9008635, "displayName" : "p-3S-RUNX2:GSK3B", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1165, "y" : 1054 }, "minX" : 1117, "maxX" : 1220, "minY" : 1004, "maxY" : 1071, "prop" : { "x" : 1117, "y" : 1037, "width" : 97, "height" : 34 }, "textPosition" : { "x" : 1123, "y" : 1036 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1214, "y" : 1037 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1214, "y" : 1037 } } }, "connectors" : [ { "edgeId" : 411, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1167, "y" : 1034 }, "to" : { "x" : 1173, "y" : 1004 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1164, "y" : 1026 }, "b" : { "x" : 1167, "y" : 1034 }, "c" : { "x" : 1172, "y" : 1028 }, "type" : "ARROW", "centre" : { "x" : 1172, "y" : 1028 } } } ] }, { "id" : 286, "reactomeId" : 629622, "displayName" : "STAT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1503, "y" : 508 }, "minX" : 1449, "maxX" : 1533, "minY" : 491, "maxY" : 519, "prop" : { "x" : 1480, "y" : 497, "width" : 47, "height" : 22 }, "textPosition" : { "x" : 1480, "y" : 497 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1527, "y" : 497 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1527, "y" : 497 } } }, "connectors" : [ { "edgeId" : 282, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1477, "y" : 511 }, "to" : { "x" : 1449, "y" : 515 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 287, "reactomeId" : 9008005, "displayName" : "RUNX2:STAT1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1478, "y" : 672 }, "minX" : 1353, "maxX" : 1530, "minY" : 655, "maxY" : 683, "prop" : { "x" : 1432, "y" : 661, "width" : 92, "height" : 22 }, "textPosition" : { "x" : 1432, "y" : 662 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1524, "y" : 661 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1524, "y" : 661 } } }, "connectors" : [ { "edgeId" : 282, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 296, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1429, "y" : 669 }, "to" : { "x" : 1353, "y" : 666 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1353, "y" : 670 }, "b" : { "x" : 1353, "y" : 662 }, "c" : { "x" : 1353, "y" : 666 }, "type" : "STOP", "centre" : { "x" : 1353, "y" : 666 } } } ] }, { "id" : 555, "reactomeId" : 9009448, "displayName" : "SMURF1 gene", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Gene", "position" : { "x" : 1141, "y" : 551 }, "minX" : 1030, "maxX" : 1182, "minY" : 524, "maxY" : 577, "prop" : { "x" : 1109, "y" : 526, "width" : 64, "height" : 51 }, "textPosition" : { "x" : 1110, "y" : 553 }, "connectors" : [ { "edgeId" : 554, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1182, "y" : 528 }, "to" : { "x" : 1030, "y" : 556 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 571, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ], "endShape" : { "a" : { "x" : 1180, "y" : 524 }, "b" : { "x" : 1173, "y" : 528 }, "c" : { "x" : 1180, "y" : 532 }, "type" : "ARROW", "centre" : { "x" : 1180, "y" : 532 } } }, { "id" : 556, "reactomeId" : 9009447, "displayName" : "RUNX2:CBFB:SMURF1 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1099, "y" : 612 }, "minX" : 1051, "maxX" : 1293, "minY" : 564, "maxY" : 630, "prop" : { "x" : 1051, "y" : 594, "width" : 97, "height" : 36 }, "textPosition" : { "x" : 1052, "y" : 595 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1148, "y" : 594 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1148, "y" : 594 } } }, "connectors" : [ { "edgeId" : 554, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 571, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1151, "y" : 600 }, "to" : { "x" : 1293, "y" : 566 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1287, "y" : 572 }, "b" : { "x" : 1293, "y" : 566 }, "c" : { "x" : 1285, "y" : 564 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1285, "y" : 564 } } } ] }, { "id" : 573, "reactomeId" : 8939693, "displayName" : "SCF (SKP2) complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 757, "y" : 801 }, "minX" : 678, "maxX" : 823, "minY" : 776, "maxY" : 940, "prop" : { "x" : 722, "y" : 782, "width" : 71, "height" : 39 }, "textPosition" : { "x" : 728, "y" : 772 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 793, "y" : 782 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 793, "y" : 782 } } }, "connectors" : [ { "edgeId" : 572, "type" : "INPUT", "segments" : [ { "from" : { "x" : 796, "y" : 799 }, "to" : { "x" : 823, "y" : 799 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 575, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 719, "y" : 790 }, "to" : { "x" : 694, "y" : 782 } }, { "from" : { "x" : 694, "y" : 782 }, "to" : { "x" : 678, "y" : 921 } }, { "from" : { "x" : 678, "y" : 921 }, "to" : { "x" : 678, "y" : 940 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 711, "y" : 792 }, "b" : { "x" : 719, "y" : 790 }, "c" : { "x" : 714, "y" : 784 }, "type" : "ARROW", "centre" : { "x" : 714, "y" : 784 } } } ] }, { "id" : 574, "reactomeId" : 8939702, "displayName" : "RUNX2:SCF(SKP2)", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 795, "y" : 894 }, "minX" : 702, "maxX" : 836, "minY" : 870, "maxY" : 941, "prop" : { "x" : 760, "y" : 876, "width" : 70, "height" : 36 }, "textPosition" : { "x" : 768, "y" : 863 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 830, "y" : 876 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 830, "y" : 876 } } }, "connectors" : [ { "edgeId" : 572, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 575, "type" : "INPUT", "segments" : [ { "from" : { "x" : 763, "y" : 915 }, "to" : { "x" : 713, "y" : 941 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 575, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 757, "y" : 894 }, "to" : { "x" : 722, "y" : 895 } }, { "from" : { "x" : 722, "y" : 895 }, "to" : { "x" : 709, "y" : 916 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 706, "y" : 920 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 706, "y" : 920 } } } ] }, { "id" : 576, "reactomeId" : 9008122, "displayName" : "PolyUb-RUNX2", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 710, "y" : 1098 }, "minX" : 661, "maxX" : 760, "minY" : 940, "maxY" : 1109, "prop" : { "x" : 661, "y" : 1087, "width" : 99, "height" : 22 }, "textPosition" : { "x" : 663, "y" : 1087 }, "connectors" : [ { "edgeId" : 1080, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 575, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 707, "y" : 1081 }, "to" : { "x" : 678, "y" : 940 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 702, "y" : 1075 }, "b" : { "x" : 707, "y" : 1081 }, "c" : { "x" : 710, "y" : 1073 }, "type" : "ARROW", "centre" : { "x" : 710, "y" : 1073 } } } ] }, { "id" : 67, "reactomeId" : 9007721, "displayName" : "DLX5,(DLX6):RUNX2 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 868, "y" : 693 }, "minX" : 825, "maxX" : 917, "minY" : 484, "maxY" : 711, "prop" : { "x" : 825, "y" : 676, "width" : 86, "height" : 35 }, "textPosition" : { "x" : 825, "y" : 676 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 911, "y" : 676 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 911, "y" : 676 } } }, "connectors" : [ { "edgeId" : 65, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 47, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 869, "y" : 673 }, "to" : { "x" : 887, "y" : 484 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 890, "y" : 491 }, "b" : { "x" : 887, "y" : 484 }, "c" : { "x" : 882, "y" : 491 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 882, "y" : 491 } } } ] }, { "id" : 580, "reactomeId" : 9016495, "displayName" : "RUNX2-P1:CBFB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 713, "y" : 502 }, "minX" : 641, "maxX" : 757, "minY" : 479, "maxY" : 519, "prop" : { "x" : 675, "y" : 485, "width" : 76, "height" : 34 }, "textPosition" : { "x" : 676, "y" : 484 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 751, "y" : 485 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 751, "y" : 485 } } }, "connectors" : [ { "edgeId" : 396, "type" : "INPUT", "segments" : [ { "from" : { "x" : 672, "y" : 496 }, "to" : { "x" : 641, "y" : 492 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 68, "reactomeId" : 201463, "displayName" : "BMP2 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 528, "y" : 1274 }, "minX" : 500, "maxX" : 696, "minY" : 709, "maxY" : 1291, "prop" : { "x" : 500, "y" : 1258, "width" : 56, "height" : 33 }, "textPosition" : { "x" : 505, "y" : 1256 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 556, "y" : 1258 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 556, "y" : 1258 } } }, "connectors" : [ { "edgeId" : 65, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 532, "y" : 1255 }, "to" : { "x" : 694, "y" : 709 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 696, "y" : 717 }, "b" : { "x" : 694, "y" : 709 }, "c" : { "x" : 688, "y" : 715 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 688, "y" : 715 } } } ] }, { "id" : 325, "reactomeId" : 9008029, "displayName" : "HIVEP3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1516, "y" : 301 }, "minX" : 1481, "maxX" : 1593, "minY" : 277, "maxY" : 337, "prop" : { "x" : 1491, "y" : 290, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 1494, "y" : 284 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1542, "y" : 290 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1542, "y" : 290 } } }, "connectors" : [ { "edgeId" : 324, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1505, "y" : 315 }, "to" : { "x" : 1481, "y" : 337 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 382, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1545, "y" : 293 }, "to" : { "x" : 1593, "y" : 277 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1550, "y" : 287 }, "b" : { "x" : 1545, "y" : 293 }, "c" : { "x" : 1553, "y" : 295 }, "type" : "ARROW", "centre" : { "x" : 1553, "y" : 295 } } } ] }, { "id" : 326, "reactomeId" : 976037, "displayName" : "WWP1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1553, "y" : 334 }, "minX" : 1481, "maxX" : 1593, "minY" : 277, "maxY" : 345, "prop" : { "x" : 1531, "y" : 323, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 1534, "y" : 317 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1575, "y" : 323 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1575, "y" : 323 } } }, "connectors" : [ { "edgeId" : 324, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1528, "y" : 334 }, "to" : { "x" : 1481, "y" : 337 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 382, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1560, "y" : 320 }, "to" : { "x" : 1593, "y" : 277 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1561, "y" : 312 }, "b" : { "x" : 1560, "y" : 320 }, "c" : { "x" : 1567, "y" : 317 }, "type" : "ARROW", "centre" : { "x" : 1567, "y" : 317 } } } ] }, { "id" : 327, "reactomeId" : 9008033, "displayName" : "RUNX2:HIVEP3:WWP1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1457, "y" : 193 }, "minX" : 1428, "maxX" : 1537, "minY" : 147, "maxY" : 221, "prop" : { "x" : 1428, "y" : 166, "width" : 58, "height" : 55 }, "textPosition" : { "x" : 1429, "y" : 172 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1486, "y" : 166 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1486, "y" : 166 } } }, "connectors" : [ { "edgeId" : 324, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 367, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1489, "y" : 184 }, "to" : { "x" : 1514, "y" : 176 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 367, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1489, "y" : 167 }, "to" : { "x" : 1509, "y" : 147 } }, { "from" : { "x" : 1509, "y" : 147 }, "to" : { "x" : 1530, "y" : 167 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1533, "y" : 170 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1533, "y" : 170 } } } ] }, { "id" : 457, "reactomeId" : 177750, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 836, "y" : 1045 }, "minX" : 726, "maxX" : 882, "minY" : 1022, "maxY" : 1062, "prop" : { "x" : 797, "y" : 1028, "width" : 79, "height" : 34 }, "textPosition" : { "x" : 798, "y" : 1013 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 876, "y" : 1028 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 876, "y" : 1028 } } }, "connectors" : [ { "edgeId" : 1080, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 794, "y" : 1043 }, "to" : { "x" : 734, "y" : 1041 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 730, "y" : 1040 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 730, "y" : 1040 } } } ] }, { "id" : 976, "reactomeId" : 9016525, "displayName" : "RUNX2-P2:CBFB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 430, "y" : 340 }, "minX" : 375, "maxX" : 616, "minY" : 295, "maxY" : 353, "prop" : { "x" : 375, "y" : 327, "width" : 110, "height" : 26 }, "textPosition" : { "x" : 378, "y" : 332 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 485, "y" : 327 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 485, "y" : 327 } } }, "connectors" : [ { "edgeId" : 975, "type" : "INPUT", "segments" : [ { "from" : { "x" : 483, "y" : 324 }, "to" : { "x" : 616, "y" : 295 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 977, "reactomeId" : 9016527, "displayName" : "RUNX2-P2:CBFB:RUNX2 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 737, "y" : 314 }, "minX" : 684, "maxX" : 841, "minY" : 291, "maxY" : 393, "prop" : { "x" : 684, "y" : 297, "width" : 107, "height" : 35 }, "textPosition" : { "x" : 693, "y" : 283 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 791, "y" : 297 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 791, "y" : 297 } } }, "connectors" : [ { "edgeId" : 9, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 760, "y" : 335 }, "to" : { "x" : 841, "y" : 393 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 833, "y" : 392 }, "b" : { "x" : 841, "y" : 393 }, "c" : { "x" : 838, "y" : 386 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 838, "y" : 386 } } }, { "edgeId" : 975, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 978, "reactomeId" : 68524, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 727, "y" : 983 }, "minX" : 708, "maxX" : 747, "minY" : 941, "maxY" : 1026, "prop" : { "x" : 708, "y" : 973, "width" : 39, "height" : 21 }, "textPosition" : { "x" : 715, "y" : 973 }, "connectors" : [ { "edgeId" : 1080, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 715, "y" : 1014 }, "b" : { "x" : 727, "y" : 1026 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 721, "y" : 1020 } } } }, { "edgeId" : 575, "type" : "INPUT", "segments" : [ { "from" : { "x" : 723, "y" : 967 }, "to" : { "x" : 713, "y" : 941 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 712, "y" : 948 }, "b" : { "x" : 724, "y" : 960 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 718, "y" : 954 } } } } ] }, { "id" : 467, "reactomeId" : 879850, "displayName" : "NR3C1:(ALDO,11DCORST,CORST,CORT) dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 422, "y" : 394 }, "minX" : 363, "maxX" : 620, "minY" : 362, "maxY" : 419, "prop" : { "x" : 363, "y" : 369, "width" : 119, "height" : 50 }, "textPosition" : { "x" : 375, "y" : 356 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 482, "y" : 369 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 482, "y" : 369 } } }, "connectors" : [ { "edgeId" : 466, "type" : "INPUT", "segments" : [ { "from" : { "x" : 485, "y" : 384 }, "to" : { "x" : 620, "y" : 362 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 468, "reactomeId" : 9009086, "displayName" : "Glucocorticoid ligand:NR3C1:RUNX2 gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 725, "y" : 373 }, "minX" : 676, "maxX" : 840, "minY" : 344, "maxY" : 400, "prop" : { "x" : 676, "y" : 350, "width" : 98, "height" : 47 }, "textPosition" : { "x" : 675, "y" : 348 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 774, "y" : 350 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 774, "y" : 350 } } }, "connectors" : [ { "edgeId" : 9, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 777, "y" : 382 }, "to" : { "x" : 839, "y" : 396 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 838, "y" : 400 }, "b" : { "x" : 840, "y" : 392 }, "c" : { "x" : 839, "y" : 396 }, "type" : "STOP", "centre" : { "x" : 839, "y" : 396 } } }, { "edgeId" : 466, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 474, "reactomeId" : 975970, "displayName" : "STUB1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1524, "y" : 404 }, "minX" : 1501, "maxX" : 1748, "minY" : 387, "maxY" : 454, "prop" : { "x" : 1501, "y" : 393, "width" : 47, "height" : 22 }, "textPosition" : { "x" : 1504, "y" : 387 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1548, "y" : 393 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1548, "y" : 393 } } }, "connectors" : [ { "edgeId" : 473, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1525, "y" : 418 }, "to" : { "x" : 1532, "y" : 454 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 493, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1551, "y" : 405 }, "to" : { "x" : 1748, "y" : 421 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1558, "y" : 402 }, "b" : { "x" : 1551, "y" : 405 }, "c" : { "x" : 1558, "y" : 410 }, "type" : "ARROW", "centre" : { "x" : 1558, "y" : 410 } } } ] }, { "id" : 475, "reactomeId" : 9009311, "displayName" : "RUNX2:STUB1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1643, "y" : 454 }, "minX" : 1614, "maxX" : 1724, "minY" : 431, "maxY" : 472, "prop" : { "x" : 1614, "y" : 437, "width" : 59, "height" : 35 }, "textPosition" : { "x" : 1617, "y" : 437 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1673, "y" : 437 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1673, "y" : 437 } } }, "connectors" : [ { "edgeId" : 473, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 493, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1676, "y" : 460 }, "to" : { "x" : 1705, "y" : 468 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 493, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1676, "y" : 448 }, "to" : { "x" : 1702, "y" : 442 } }, { "from" : { "x" : 1702, "y" : 442 }, "to" : { "x" : 1716, "y" : 451 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1720, "y" : 453 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1720, "y" : 453 } } } ] }, { "id" : 494, "reactomeId" : 9008097, "displayName" : "PolyUb-RUNX2", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1764, "y" : 337 }, "minX" : 1716, "maxX" : 1844, "minY" : 326, "maxY" : 573, "prop" : { "x" : 1716, "y" : 326, "width" : 96, "height" : 23 }, "textPosition" : { "x" : 1716, "y" : 327 }, "connectors" : [ { "edgeId" : 523, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1818, "y" : 334 }, "to" : { "x" : 1844, "y" : 333 } }, { "from" : { "x" : 1844, "y" : 333 }, "to" : { "x" : 1841, "y" : 547 } }, { "from" : { "x" : 1841, "y" : 547 }, "to" : { "x" : 1808, "y" : 573 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1825, "y" : 330 }, "b" : { "x" : 1818, "y" : 334 }, "c" : { "x" : 1825, "y" : 338 }, "type" : "ARROW", "centre" : { "x" : 1825, "y" : 338 } } }, { "edgeId" : 493, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1761, "y" : 355 }, "to" : { "x" : 1748, "y" : 421 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1764, "y" : 363 }, "b" : { "x" : 1761, "y" : 355 }, "c" : { "x" : 1756, "y" : 361 }, "type" : "ARROW", "centre" : { "x" : 1756, "y" : 361 } } }, { "edgeId" : 507, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 368, "reactomeId" : 113595, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1511, "y" : 249 }, "minX" : 1499, "maxX" : 1593, "minY" : 176, "maxY" : 277, "prop" : { "x" : 1499, "y" : 238, "width" : 25, "height" : 22 }, "textPosition" : { "x" : 1499, "y" : 238 }, "connectors" : [ { "edgeId" : 367, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1511, "y" : 232 }, "to" : { "x" : 1514, "y" : 176 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1506, "y" : 198 }, "b" : { "x" : 1518, "y" : 210 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1512, "y" : 204 } } } }, { "edgeId" : 382, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1530, "y" : 253 }, "to" : { "x" : 1593, "y" : 277 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1555, "y" : 259 }, "b" : { "x" : 1567, "y" : 271 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1561, "y" : 265 } } }, "endShape" : { "a" : { "x" : 1538, "y" : 252 }, "b" : { "x" : 1530, "y" : 253 }, "c" : { "x" : 1535, "y" : 259 }, "type" : "ARROW", "centre" : { "x" : 1535, "y" : 259 } } } ] }, { "id" : 496, "reactomeId" : 113595, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1726, "y" : 515 }, "minX" : 1705, "maxX" : 1793, "minY" : 468, "maxY" : 574, "prop" : { "x" : 1714, "y" : 504, "width" : 25, "height" : 22 }, "textPosition" : { "x" : 1714, "y" : 504 }, "connectors" : [ { "edgeId" : 523, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1723, "y" : 532 }, "to" : { "x" : 1714, "y" : 574 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1712, "y" : 547 }, "b" : { "x" : 1724, "y" : 559 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1718, "y" : 553 } } } }, { "edgeId" : 493, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1721, "y" : 498 }, "to" : { "x" : 1705, "y" : 468 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1707, "y" : 477 }, "b" : { "x" : 1719, "y" : 489 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1713, "y" : 483 } } } }, { "edgeId" : 507, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1781, "y" : 510 }, "b" : { "x" : 1793, "y" : 522 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1787, "y" : 516 } } } } ] }, { "id" : 369, "reactomeId" : 9008103, "displayName" : "PolyUb-RUNX2:HIVEP3:WWP1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1648, "y" : 188 }, "minX" : 1598, "maxX" : 1704, "minY" : 164, "maxY" : 206, "prop" : { "x" : 1598, "y" : 170, "width" : 100, "height" : 36 }, "textPosition" : { "x" : 1598, "y" : 171 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1698, "y" : 170 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1698, "y" : 170 } } }, "connectors" : [ { "edgeId" : 367, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 382, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 114, "reactomeId" : 9007751, "displayName" : "RUNX2", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1173, "y" : 689 }, "minX" : 823, "maxX" : 1201, "minY" : 678, "maxY" : 799, "prop" : { "x" : 1145, "y" : 678, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 1148, "y" : 678 }, "connectors" : [ { "edgeId" : 399, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1169, "y" : 706 }, "to" : { "x" : 1161, "y" : 725 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 296, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 572, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1139, "y" : 697 }, "to" : { "x" : 823, "y" : 799 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 383, "reactomeId" : 68819, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1646, "y" : 353 }, "minX" : 1594, "maxX" : 1761, "minY" : 267, "maxY" : 364, "prop" : { "x" : 1594, "y" : 342, "width" : 104, "height" : 22 }, "textPosition" : { "x" : 1604, "y" : 329 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1698, "y" : 342 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1698, "y" : 342 } } }, "connectors" : [ { "edgeId" : 507, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1660, "y" : 339 }, "to" : { "x" : 1754, "y" : 273 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1757, "y" : 271 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1757, "y" : 271 } } }, { "edgeId" : 382, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1645, "y" : 339 }, "to" : { "x" : 1645, "y" : 289 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1645, "y" : 285 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1645, "y" : 285 } } } ] } ], "edges" : [ { "id" : 65, "reactomeId" : 9007707, "displayName" : "DLX5,(DLX6) binds RUNX2 gene promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 697, "y" : 700 }, "minX" : 675, "maxX" : 822, "minY" : 694, "maxY" : 705, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 675, "y" : 698 }, "to" : { "x" : 697, "y" : 700 } }, { "from" : { "x" : 697, "y" : 700 }, "to" : { "x" : 822, "y" : 694 } } ], "endShape" : { "a" : { "x" : 815, "y" : 698 }, "b" : { "x" : 822, "y" : 694 }, "c" : { "x" : 815, "y" : 690 }, "type" : "ARROW", "centre" : { "x" : 815, "y" : 690 } }, "reactionShape" : { "c" : { "x" : 697, "y" : 700 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 697, "y" : 700 } }, "inputs" : [ { "id" : 136, "points" : [ { "x" : 626, "y" : 697 } ] }, { "id" : 7, "points" : [ { "x" : 595, "y" : 434 } ] } ], "outputs" : [ { "id" : 67 } ], "activators" : [ { "id" : 68, "points" : [ { "x" : 532, "y" : 1255 } ] } ] }, { "id" : 131, "reactomeId" : 9007759, "displayName" : "MSX2 binds RUNX2 gene promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 783, "y" : 761 }, "minX" : 652, "maxX" : 986, "minY" : 660, "maxY" : 766, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 652, "y" : 749 }, "to" : { "x" : 783, "y" : 761 } }, { "from" : { "x" : 783, "y" : 761 }, "to" : { "x" : 967, "y" : 714 } }, { "from" : { "x" : 967, "y" : 714 }, "to" : { "x" : 986, "y" : 660 } } ], "endShape" : { "a" : { "x" : 987, "y" : 668 }, "b" : { "x" : 986, "y" : 660 }, "c" : { "x" : 980, "y" : 665 }, "type" : "ARROW", "centre" : { "x" : 980, "y" : 665 } }, "reactionShape" : { "c" : { "x" : 783, "y" : 761 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 783, "y" : 761 } }, "inputs" : [ { "id" : 7, "points" : [ { "x" : 595, "y" : 434 } ] }, { "id" : 132, "points" : [ { "x" : 622, "y" : 828 } ] } ], "outputs" : [ { "id" : 133 } ] }, { "id" : 324, "reactomeId" : 9008036, "displayName" : "RUNX2 binds to HIVEP3 and WWP1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1472, "y" : 284 }, "minX" : 1461, "maxX" : 1481, "minY" : 224, "maxY" : 337, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1481, "y" : 337 }, "to" : { "x" : 1472, "y" : 284 } }, { "from" : { "x" : 1472, "y" : 284 }, "to" : { "x" : 1461, "y" : 224 } } ], "endShape" : { "a" : { "x" : 1466, "y" : 230 }, "b" : { "x" : 1461, "y" : 224 }, "c" : { "x" : 1458, "y" : 232 }, "type" : "ARROW", "centre" : { "x" : 1458, "y" : 232 } }, "reactionShape" : { "c" : { "x" : 1472, "y" : 284 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1472, "y" : 284 } }, "inputs" : [ { "id" : 325, "points" : [ { "x" : 1505, "y" : 315 } ] }, { "id" : 326, "points" : [ { "x" : 1528, "y" : 334 } ] }, { "id" : 283, "points" : [ { "x" : 1452, "y" : 434 } ] } ], "outputs" : [ { "id" : 327 } ] }, { "id" : 5, "reactomeId" : 8939904, "displayName" : "Activated ESR1 binds the RUNX2 gene promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 645, "y" : 262 }, "minX" : 542, "maxX" : 774, "minY" : 257, "maxY" : 287, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 542, "y" : 287 }, "to" : { "x" : 645, "y" : 262 } }, { "from" : { "x" : 645, "y" : 262 }, "to" : { "x" : 774, "y" : 268 } } ], "endShape" : { "a" : { "x" : 767, "y" : 272 }, "b" : { "x" : 774, "y" : 268 }, "c" : { "x" : 767, "y" : 264 }, "type" : "ARROW", "centre" : { "x" : 767, "y" : 264 } }, "reactionShape" : { "c" : { "x" : 645, "y" : 262 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 645, "y" : 262 } }, "inputs" : [ { "id" : 6, "points" : [ { "x" : 490, "y" : 292 } ] }, { "id" : 7, "points" : [ { "x" : 595, "y" : 434 } ] } ], "outputs" : [ { "id" : 8 } ] }, { "id" : 520, "reactomeId" : 9009401, "displayName" : "RUNX2 binds SMURF1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1612, "y" : 527 }, "minX" : 1567, "maxX" : 1699, "minY" : 500, "maxY" : 620, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1567, "y" : 500 }, "to" : { "x" : 1612, "y" : 527 } }, { "from" : { "x" : 1612, "y" : 527 }, "to" : { "x" : 1699, "y" : 620 } } ], "endShape" : { "a" : { "x" : 1691, "y" : 618 }, "b" : { "x" : 1699, "y" : 620 }, "c" : { "x" : 1697, "y" : 612 }, "type" : "ARROW", "centre" : { "x" : 1697, "y" : 612 } }, "reactionShape" : { "c" : { "x" : 1612, "y" : 527 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1612, "y" : 527 } }, "inputs" : [ { "id" : 283, "points" : [ { "x" : 1480, "y" : 461 } ] }, { "id" : 521, "points" : [ { "x" : 1554, "y" : 549 } ] } ], "outputs" : [ { "id" : 522 } ] }, { "id" : 9, "reactomeId" : 8939900, "displayName" : "RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 848, "y" : 398 }, "minX" : 595, "maxX" : 1264, "minY" : 378, "maxY" : 434, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 595, "y" : 434 }, "to" : { "x" : 848, "y" : 398 } }, { "from" : { "x" : 848, "y" : 398 }, "to" : { "x" : 1264, "y" : 378 } } ], "endShape" : { "a" : { "x" : 1257, "y" : 382 }, "b" : { "x" : 1264, "y" : 378 }, "c" : { "x" : 1257, "y" : 374 }, "type" : "ARROW", "centre" : { "x" : 1257, "y" : 374 } }, "reactionShape" : { "a" : { "x" : 842, "y" : 392 }, "b" : { "x" : 854, "y" : 404 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 848, "y" : 398 } }, "inputs" : [ { "id" : 7 } ], "outputs" : [ { "id" : 272 } ], "inhibitors" : [ { "id" : 13, "points" : [ { "x" : 1018, "y" : 193 } ] }, { "id" : 468, "points" : [ { "x" : 777, "y" : 382 } ] } ], "activators" : [ { "id" : 11, "points" : [ { "x" : 1144, "y" : 151 } ] }, { "id" : 8, "points" : [ { "x" : 827, "y" : 292 } ] }, { "id" : 12, "points" : [ { "x" : 900, "y" : 233 } ] }, { "id" : 977, "points" : [ { "x" : 760, "y" : 335 } ] } ] }, { "id" : 523, "reactomeId" : 9009403, "displayName" : "SMURF1 polyubiquitinates RUNX2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1766, "y" : 572 }, "minX" : 1714, "maxX" : 1808, "minY" : 566, "maxY" : 578, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1714, "y" : 574 }, "to" : { "x" : 1766, "y" : 572 } }, { "from" : { "x" : 1766, "y" : 572 }, "to" : { "x" : 1808, "y" : 573 } } ], "reactionShape" : { "a" : { "x" : 1760, "y" : 566 }, "b" : { "x" : 1772, "y" : 578 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1766, "y" : 572 } }, "inputs" : [ { "id" : 522, "points" : [ { "x" : 1714, "y" : 620 } ] }, { "id" : 496, "points" : [ { "x" : 1723, "y" : 532 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 494, "points" : [ { "x" : 1818, "y" : 334 }, { "x" : 1844, "y" : 333 }, { "x" : 1841, "y" : 547 } ] }, { "id" : 521, "points" : [ { "x" : 1555, "y" : 579 }, { "x" : 1590, "y" : 679 }, { "x" : 1805, "y" : 680 } ] } ], "catalysts" : [ { "id" : 522, "points" : [ { "x" : 1734, "y" : 620 }, { "x" : 1754, "y" : 605 } ] } ] }, { "id" : 396, "reactomeId" : 9008345, "displayName" : "RUNX2-P1 binds RUNX2 gene promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 655, "y" : 526 }, "minX" : 641, "maxX" : 706, "minY" : 492, "maxY" : 560, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 641, "y" : 492 }, "to" : { "x" : 655, "y" : 526 } }, { "from" : { "x" : 655, "y" : 526 }, "to" : { "x" : 706, "y" : 560 } } ], "endShape" : { "a" : { "x" : 698, "y" : 559 }, "b" : { "x" : 706, "y" : 560 }, "c" : { "x" : 702, "y" : 553 }, "type" : "ARROW", "centre" : { "x" : 702, "y" : 553 } }, "reactionShape" : { "c" : { "x" : 655, "y" : 526 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 655, "y" : 526 } }, "inputs" : [ { "id" : 7, "points" : [ { "x" : 595, "y" : 434 } ] }, { "id" : 580, "points" : [ { "x" : 672, "y" : 496 } ] } ], "outputs" : [ { "id" : 398 } ] }, { "id" : 975, "reactomeId" : 9016526, "displayName" : "RUNX2-P2 binds RUNX2 gene promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 649, "y" : 296 }, "minX" : 616, "maxX" : 681, "minY" : 291, "maxY" : 303, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 616, "y" : 295 }, "to" : { "x" : 649, "y" : 296 } }, { "from" : { "x" : 649, "y" : 296 }, "to" : { "x" : 681, "y" : 303 } } ], "endShape" : { "a" : { "x" : 673, "y" : 305 }, "b" : { "x" : 681, "y" : 303 }, "c" : { "x" : 675, "y" : 298 }, "type" : "ARROW", "centre" : { "x" : 675, "y" : 298 } }, "reactionShape" : { "c" : { "x" : 649, "y" : 296 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 649, "y" : 296 } }, "inputs" : [ { "id" : 7, "points" : [ { "x" : 595, "y" : 434 } ] }, { "id" : 976, "points" : [ { "x" : 483, "y" : 324 } ] } ], "outputs" : [ { "id" : 977 } ] }, { "id" : 15, "reactomeId" : 8939929, "displayName" : "ESRRA:PPARG1CA binds the RUNX2 gene promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 637, "y" : 221 }, "minX" : 550, "maxX" : 840, "minY" : 213, "maxY" : 238, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 550, "y" : 238 }, "to" : { "x" : 637, "y" : 221 } }, { "from" : { "x" : 637, "y" : 221 }, "to" : { "x" : 840, "y" : 213 } } ], "endShape" : { "a" : { "x" : 833, "y" : 217 }, "b" : { "x" : 840, "y" : 213 }, "c" : { "x" : 833, "y" : 209 }, "type" : "ARROW", "centre" : { "x" : 833, "y" : 209 } }, "reactionShape" : { "c" : { "x" : 637, "y" : 221 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 637, "y" : 221 } }, "inputs" : [ { "id" : 16, "points" : [ { "x" : 493, "y" : 244 } ] }, { "id" : 7, "points" : [ { "x" : 595, "y" : 434 } ] } ], "outputs" : [ { "id" : 12 } ] }, { "id" : 399, "reactomeId" : 9008476, "displayName" : "RUNX2 binds GSK3B", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1169, "y" : 808 }, "minX" : 1161, "maxX" : 1174, "minY" : 725, "maxY" : 873, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1161, "y" : 725 }, "to" : { "x" : 1169, "y" : 808 } }, { "from" : { "x" : 1169, "y" : 808 }, "to" : { "x" : 1174, "y" : 873 } } ], "endShape" : { "a" : { "x" : 1169, "y" : 866 }, "b" : { "x" : 1174, "y" : 873 }, "c" : { "x" : 1177, "y" : 866 }, "type" : "ARROW", "centre" : { "x" : 1177, "y" : 866 } }, "reactionShape" : { "c" : { "x" : 1169, "y" : 808 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1169, "y" : 808 } }, "inputs" : [ { "id" : 114, "points" : [ { "x" : 1169, "y" : 706 } ] }, { "id" : 400, "points" : [ { "x" : 1065, "y" : 762 } ] } ], "outputs" : [ { "id" : 401 } ] }, { "id" : 17, "reactomeId" : 8939938, "displayName" : "ESRRA:PPARG1CB binds the RUNX2 gene promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 624, "y" : 180 }, "minX" : 562, "maxX" : 975, "minY" : 170, "maxY" : 198, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 562, "y" : 198 }, "to" : { "x" : 624, "y" : 180 } }, { "from" : { "x" : 624, "y" : 180 }, "to" : { "x" : 975, "y" : 170 } } ], "endShape" : { "a" : { "x" : 968, "y" : 174 }, "b" : { "x" : 975, "y" : 170 }, "c" : { "x" : 968, "y" : 166 }, "type" : "ARROW", "centre" : { "x" : 968, "y" : 166 } }, "reactionShape" : { "c" : { "x" : 624, "y" : 180 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 624, "y" : 180 } }, "inputs" : [ { "id" : 7, "points" : [ { "x" : 595, "y" : 434 } ] }, { "id" : 18, "points" : [ { "x" : 497, "y" : 196 } ] } ], "outputs" : [ { "id" : 13 } ] }, { "id" : 466, "reactomeId" : 9009085, "displayName" : "DEXA:NR3C1 complex binds RUNX2 gene proximal promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 643, "y" : 361 }, "minX" : 620, "maxX" : 673, "minY" : 356, "maxY" : 366, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 620, "y" : 362 }, "to" : { "x" : 643, "y" : 361 } }, { "from" : { "x" : 643, "y" : 361 }, "to" : { "x" : 673, "y" : 365 } } ], "endShape" : { "a" : { "x" : 666, "y" : 368 }, "b" : { "x" : 673, "y" : 365 }, "c" : { "x" : 667, "y" : 360 }, "type" : "ARROW", "centre" : { "x" : 667, "y" : 360 } }, "reactionShape" : { "c" : { "x" : 643, "y" : 361 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 643, "y" : 361 } }, "inputs" : [ { "id" : 7, "points" : [ { "x" : 595, "y" : 434 } ] }, { "id" : 467, "points" : [ { "x" : 485, "y" : 384 } ] } ], "outputs" : [ { "id" : 468 } ] }, { "id" : 19, "reactomeId" : 8940032, "displayName" : "TWIST1 binds the RUNX2 gene promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 663, "y" : 130 }, "minX" : 579, "maxX" : 1118, "minY" : 125, "maxY" : 162, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 579, "y" : 162 }, "to" : { "x" : 663, "y" : 130 } }, { "from" : { "x" : 663, "y" : 130 }, "to" : { "x" : 1118, "y" : 130 } } ], "endShape" : { "a" : { "x" : 1111, "y" : 134 }, "b" : { "x" : 1118, "y" : 130 }, "c" : { "x" : 1111, "y" : 126 }, "type" : "ARROW", "centre" : { "x" : 1111, "y" : 126 } }, "reactionShape" : { "c" : { "x" : 663, "y" : 130 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 663, "y" : 130 } }, "inputs" : [ { "id" : 20, "points" : [ { "x" : 394, "y" : 149 } ] }, { "id" : 7, "points" : [ { "x" : 595, "y" : 434 } ] } ], "outputs" : [ { "id" : 11 } ] }, { "id" : 473, "reactomeId" : 9009309, "displayName" : "RUNX2 binds STUB1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1560, "y" : 449 }, "minX" : 1532, "maxX" : 1611, "minY" : 444, "maxY" : 454, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1532, "y" : 454 }, "to" : { "x" : 1560, "y" : 449 } }, { "from" : { "x" : 1560, "y" : 449 }, "to" : { "x" : 1611, "y" : 452 } } ], "endShape" : { "a" : { "x" : 1604, "y" : 456 }, "b" : { "x" : 1611, "y" : 452 }, "c" : { "x" : 1604, "y" : 448 }, "type" : "ARROW", "centre" : { "x" : 1604, "y" : 448 } }, "reactionShape" : { "c" : { "x" : 1560, "y" : 449 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1560, "y" : 449 } }, "inputs" : [ { "id" : 283, "points" : [ { "x" : 1480, "y" : 451 } ] }, { "id" : 474, "points" : [ { "x" : 1525, "y" : 418 } ] } ], "outputs" : [ { "id" : 475 } ] }, { "id" : 282, "reactomeId" : 9008015, "displayName" : "RUNX2 binds STAT1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1456, "y" : 563 }, "minX" : 1449, "maxX" : 1475, "minY" : 515, "maxY" : 658, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1449, "y" : 515 }, "to" : { "x" : 1456, "y" : 563 } }, { "from" : { "x" : 1456, "y" : 563 }, "to" : { "x" : 1475, "y" : 658 } } ], "endShape" : { "a" : { "x" : 1470, "y" : 652 }, "b" : { "x" : 1475, "y" : 658 }, "c" : { "x" : 1478, "y" : 650 }, "type" : "ARROW", "centre" : { "x" : 1478, "y" : 650 } }, "reactionShape" : { "c" : { "x" : 1456, "y" : 563 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1456, "y" : 563 } }, "inputs" : [ { "id" : 283, "points" : [ { "x" : 1449, "y" : 468 } ] }, { "id" : 286, "points" : [ { "x" : 1477, "y" : 511 } ] } ], "outputs" : [ { "id" : 287 } ] }, { "id" : 27, "reactomeId" : 8985293, "displayName" : "NKX3-2 binds RUNX2 gene promoter", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 680, "y" : 628 }, "minX" : 608, "maxX" : 759, "minY" : 623, "maxY" : 637, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 608, "y" : 627 }, "to" : { "x" : 680, "y" : 628 } }, { "from" : { "x" : 680, "y" : 628 }, "to" : { "x" : 759, "y" : 637 } } ], "endShape" : { "a" : { "x" : 752, "y" : 640 }, "b" : { "x" : 759, "y" : 637 }, "c" : { "x" : 753, "y" : 632 }, "type" : "ARROW", "centre" : { "x" : 753, "y" : 632 } }, "reactionShape" : { "c" : { "x" : 680, "y" : 628 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 680, "y" : 628 } }, "inputs" : [ { "id" : 7, "points" : [ { "x" : 595, "y" : 434 } ] }, { "id" : 26, "points" : [ { "x" : 526, "y" : 700 } ] } ], "outputs" : [ { "id" : 14 } ] }, { "id" : 411, "reactomeId" : 9008480, "displayName" : "GSK3B phosphorylates RUNX2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1173, "y" : 972 }, "minX" : 1167, "maxX" : 1179, "minY" : 936, "maxY" : 1004, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1176, "y" : 936 }, "to" : { "x" : 1173, "y" : 972 } }, { "from" : { "x" : 1173, "y" : 972 }, "to" : { "x" : 1173, "y" : 1004 } } ], "reactionShape" : { "a" : { "x" : 1167, "y" : 966 }, "b" : { "x" : 1179, "y" : 978 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1173, "y" : 972 } }, "inputs" : [ { "id" : 412, "points" : [ { "x" : 1127, "y" : 933 } ], "stoichiometry" : 3 }, { "id" : 401, "points" : [ { "x" : 1176, "y" : 918 } ] } ], "outputs" : [ { "id" : 413, "points" : [ { "x" : 1131, "y" : 985 } ], "stoichiometry" : 3 }, { "id" : 414, "points" : [ { "x" : 1167, "y" : 1034 } ] } ], "catalysts" : [ { "id" : 401, "points" : [ { "x" : 1189, "y" : 918 }, { "x" : 1212, "y" : 949 } ] } ] }, { "id" : 296, "reactomeId" : 9007999, "displayName" : "RUNX2 translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1344, "y" : 666 }, "minX" : 1207, "maxX" : 1443, "minY" : 468, "maxY" : 685, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1443, "y" : 468 }, "to" : { "x" : 1344, "y" : 666 } }, { "from" : { "x" : 1344, "y" : 666 }, "to" : { "x" : 1207, "y" : 685 } } ], "endShape" : { "a" : { "x" : 1213, "y" : 680 }, "b" : { "x" : 1207, "y" : 685 }, "c" : { "x" : 1214, "y" : 688 }, "type" : "ARROW", "centre" : { "x" : 1214, "y" : 688 } }, "reactionShape" : { "a" : { "x" : 1338, "y" : 660 }, "b" : { "x" : 1350, "y" : 672 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1344, "y" : 666 } }, "inputs" : [ { "id" : 283 } ], "outputs" : [ { "id" : 114 } ], "inhibitors" : [ { "id" : 287, "points" : [ { "x" : 1429, "y" : 669 } ] } ] }, { "id" : 554, "reactomeId" : 9009451, "displayName" : "RUNX2 binds SMURF1 gene", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1052, "y" : 567 }, "minX" : 1030, "maxX" : 1080, "minY" : 556, "maxY" : 591, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1030, "y" : 556 }, "to" : { "x" : 1052, "y" : 567 } }, { "from" : { "x" : 1052, "y" : 567 }, "to" : { "x" : 1080, "y" : 591 } } ], "endShape" : { "a" : { "x" : 1072, "y" : 590 }, "b" : { "x" : 1080, "y" : 591 }, "c" : { "x" : 1077, "y" : 583 }, "type" : "ARROW", "centre" : { "x" : 1077, "y" : 583 } }, "reactionShape" : { "c" : { "x" : 1052, "y" : 567 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1052, "y" : 567 } }, "inputs" : [ { "id" : 555, "points" : [ { "x" : 1182, "y" : 528 } ] }, { "id" : 397, "points" : [ { "x" : 1006, "y" : 547 } ] } ], "outputs" : [ { "id" : 556 } ] }, { "id" : 493, "reactomeId" : 9009308, "displayName" : "STUB1 polyubiquitinates RUNX2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1730, "y" : 459 }, "minX" : 1705, "maxX" : 1748, "minY" : 421, "maxY" : 468, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1705, "y" : 468 }, "to" : { "x" : 1730, "y" : 459 } }, { "from" : { "x" : 1730, "y" : 459 }, "to" : { "x" : 1748, "y" : 421 } } ], "reactionShape" : { "a" : { "x" : 1724, "y" : 453 }, "b" : { "x" : 1736, "y" : 465 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1730, "y" : 459 } }, "inputs" : [ { "id" : 475, "points" : [ { "x" : 1676, "y" : 460 } ] }, { "id" : 496, "points" : [ { "x" : 1721, "y" : 498 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 494, "points" : [ { "x" : 1761, "y" : 355 } ] }, { "id" : 474, "points" : [ { "x" : 1551, "y" : 405 } ] } ], "catalysts" : [ { "id" : 475, "points" : [ { "x" : 1676, "y" : 448 }, { "x" : 1702, "y" : 442 } ] } ] }, { "id" : 367, "reactomeId" : 9008076, "displayName" : "WWP1 polyubiquitinates RUNX2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1542, "y" : 178 }, "minX" : 1514, "maxX" : 1595, "minY" : 172, "maxY" : 184, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1514, "y" : 176 }, "to" : { "x" : 1542, "y" : 178 } }, { "from" : { "x" : 1542, "y" : 178 }, "to" : { "x" : 1595, "y" : 183 } } ], "endShape" : { "a" : { "x" : 1588, "y" : 186 }, "b" : { "x" : 1595, "y" : 183 }, "c" : { "x" : 1588, "y" : 178 }, "type" : "ARROW", "centre" : { "x" : 1588, "y" : 178 } }, "reactionShape" : { "a" : { "x" : 1536, "y" : 172 }, "b" : { "x" : 1548, "y" : 184 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1542, "y" : 178 } }, "inputs" : [ { "id" : 327, "points" : [ { "x" : 1489, "y" : 184 } ] }, { "id" : 368, "points" : [ { "x" : 1511, "y" : 232 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 369 } ], "catalysts" : [ { "id" : 327, "points" : [ { "x" : 1489, "y" : 167 }, { "x" : 1509, "y" : 147 } ] } ] }, { "id" : 47, "reactomeId" : 9007686, "displayName" : "RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6)", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 888, "y" : 475 }, "minX" : 595, "maxX" : 1260, "minY" : 434, "maxY" : 499, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 595, "y" : 434 }, "to" : { "x" : 888, "y" : 475 } }, { "from" : { "x" : 888, "y" : 475 }, "to" : { "x" : 1260, "y" : 499 } } ], "endShape" : { "a" : { "x" : 1253, "y" : 503 }, "b" : { "x" : 1260, "y" : 499 }, "c" : { "x" : 1253, "y" : 495 }, "type" : "ARROW", "centre" : { "x" : 1253, "y" : 495 } }, "reactionShape" : { "a" : { "x" : 882, "y" : 469 }, "b" : { "x" : 894, "y" : 481 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 888, "y" : 475 } }, "inputs" : [ { "id" : 7 } ], "outputs" : [ { "id" : 275 } ], "inhibitors" : [ { "id" : 14, "points" : [ { "x" : 815, "y" : 621 } ] }, { "id" : 133, "points" : [ { "x" : 980, "y" : 618 } ] }, { "id" : 398, "points" : [ { "x" : 759, "y" : 560 } ] } ], "activators" : [ { "id" : 67, "points" : [ { "x" : 869, "y" : 673 } ] } ] }, { "id" : 1080, "reactomeId" : 8939801, "displayName" : "26S proteasome degrades PolyUb-RUNX2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 718, "y" : 1040 }, "minX" : 711, "maxX" : 725, "minY" : 1000, "maxY" : 1081, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 711, "y" : 1081 }, "to" : { "x" : 718, "y" : 1040 } }, { "from" : { "x" : 718, "y" : 1040 }, "to" : { "x" : 725, "y" : 1000 } } ], "endShape" : { "a" : { "x" : 728, "y" : 1008 }, "b" : { "x" : 725, "y" : 1000 }, "c" : { "x" : 720, "y" : 1006 }, "type" : "ARROW", "centre" : { "x" : 720, "y" : 1006 } }, "reactionShape" : { "a" : { "x" : 712, "y" : 1034 }, "b" : { "x" : 724, "y" : 1046 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 718, "y" : 1040 } }, "inputs" : [ { "id" : 576 } ], "outputs" : [ { "id" : 978, "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 457, "points" : [ { "x" : 794, "y" : 1043 } ] } ] }, { "id" : 507, "reactomeId" : 9009362, "displayName" : "Proteasome degrades PolyUb-RUNX2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1767, "y" : 264 }, "minX" : 1745, "maxX" : 1833, "minY" : 204, "maxY" : 517, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1764, "y" : 320 }, "to" : { "x" : 1767, "y" : 264 } }, { "from" : { "x" : 1767, "y" : 264 }, "to" : { "x" : 1750, "y" : 204 } }, { "from" : { "x" : 1750, "y" : 204 }, "to" : { "x" : 1833, "y" : 205 } }, { "from" : { "x" : 1833, "y" : 205 }, "to" : { "x" : 1829, "y" : 517 } }, { "from" : { "x" : 1829, "y" : 517 }, "to" : { "x" : 1745, "y" : 515 } } ], "endShape" : { "a" : { "x" : 1752, "y" : 511 }, "b" : { "x" : 1745, "y" : 515 }, "c" : { "x" : 1752, "y" : 519 }, "type" : "ARROW", "centre" : { "x" : 1752, "y" : 519 } }, "reactionShape" : { "a" : { "x" : 1761, "y" : 258 }, "b" : { "x" : 1773, "y" : 270 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1767, "y" : 264 } }, "inputs" : [ { "id" : 494 } ], "outputs" : [ { "id" : 496, "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 383, "points" : [ { "x" : 1660, "y" : 339 } ] } ] }, { "id" : 571, "reactomeId" : 9009452, "displayName" : "SMURF1 gene expression is stimulated by RUNX2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1302, "y" : 564 }, "minX" : 1182, "maxX" : 1562, "minY" : 528, "maxY" : 754, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1182, "y" : 528 }, "to" : { "x" : 1302, "y" : 564 } }, { "from" : { "x" : 1302, "y" : 564 }, "to" : { "x" : 1314, "y" : 748 } }, { "from" : { "x" : 1314, "y" : 748 }, "to" : { "x" : 1562, "y" : 754 } }, { "from" : { "x" : 1562, "y" : 754 }, "to" : { "x" : 1552, "y" : 579 } } ], "endShape" : { "a" : { "x" : 1556, "y" : 586 }, "b" : { "x" : 1552, "y" : 579 }, "c" : { "x" : 1548, "y" : 586 }, "type" : "ARROW", "centre" : { "x" : 1548, "y" : 586 } }, "reactionShape" : { "a" : { "x" : 1296, "y" : 558 }, "b" : { "x" : 1308, "y" : 570 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1302, "y" : 564 } }, "inputs" : [ { "id" : 555 } ], "outputs" : [ { "id" : 521 } ], "activators" : [ { "id" : 556, "points" : [ { "x" : 1151, "y" : 600 } ] } ] }, { "id" : 572, "reactomeId" : 8939688, "displayName" : "SCF(SKP2) complex binds RUNX2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 818, "y" : 839 }, "minX" : 802, "maxX" : 823, "minY" : 799, "maxY" : 873, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 823, "y" : 799 }, "to" : { "x" : 818, "y" : 839 } }, { "from" : { "x" : 818, "y" : 839 }, "to" : { "x" : 802, "y" : 873 } } ], "endShape" : { "a" : { "x" : 801, "y" : 865 }, "b" : { "x" : 802, "y" : 873 }, "c" : { "x" : 809, "y" : 868 }, "type" : "ARROW", "centre" : { "x" : 809, "y" : 868 } }, "reactionShape" : { "c" : { "x" : 818, "y" : 839 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 818, "y" : 839 } }, "inputs" : [ { "id" : 114, "points" : [ { "x" : 1139, "y" : 697 } ] }, { "id" : 573, "points" : [ { "x" : 796, "y" : 799 } ] } ], "outputs" : [ { "id" : 574 } ] }, { "id" : 382, "reactomeId" : 9008110, "displayName" : "Proteasome degrades polyubiquitinated RUNX2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1645, "y" : 273 }, "minX" : 1593, "maxX" : 1651, "minY" : 209, "maxY" : 279, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1647, "y" : 209 }, "to" : { "x" : 1645, "y" : 273 } }, { "from" : { "x" : 1645, "y" : 273 }, "to" : { "x" : 1593, "y" : 277 } } ], "reactionShape" : { "a" : { "x" : 1639, "y" : 267 }, "b" : { "x" : 1651, "y" : 279 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1645, "y" : 273 } }, "inputs" : [ { "id" : 369 } ], "outputs" : [ { "id" : 326, "points" : [ { "x" : 1560, "y" : 320 } ] }, { "id" : 368, "points" : [ { "x" : 1530, "y" : 253 } ], "stoichiometry" : 3 }, { "id" : 325, "points" : [ { "x" : 1545, "y" : 293 } ] } ], "catalysts" : [ { "id" : 383, "points" : [ { "x" : 1645, "y" : 339 } ] } ] }, { "id" : 575, "reactomeId" : 8939706, "displayName" : "SCF(SKP2) polyubiquitinates RUNX2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 700, "y" : 930 }, "minX" : 678, "maxX" : 713, "minY" : 924, "maxY" : 941, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 713, "y" : 941 }, "to" : { "x" : 700, "y" : 930 } }, { "from" : { "x" : 700, "y" : 930 }, "to" : { "x" : 678, "y" : 940 } } ], "reactionShape" : { "a" : { "x" : 694, "y" : 924 }, "b" : { "x" : 706, "y" : 936 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 700, "y" : 930 } }, "inputs" : [ { "id" : 574, "points" : [ { "x" : 763, "y" : 915 } ] }, { "id" : 978, "points" : [ { "x" : 723, "y" : 967 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 573, "points" : [ { "x" : 719, "y" : 790 }, { "x" : 694, "y" : 782 }, { "x" : 678, "y" : 921 } ] }, { "id" : 576, "points" : [ { "x" : 707, "y" : 1081 } ] } ], "catalysts" : [ { "id" : 574, "points" : [ { "x" : 757, "y" : 894 }, { "x" : 722, "y" : 895 } ] } ] } ], "compartments" : [ { "id" : 1, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 946, "y" : 602 }, "minX" : 0, "maxX" : 1892, "minY" : 0, "maxY" : 1204, "prop" : { "x" : 0, "y" : 0, "width" : 1892, "height" : 1204 }, "textPosition" : { "x" : 18, "y" : 1156 }, "insets" : { "x" : 14, "y" : 14, "width" : 1865, "height" : 1178 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 4, 272, 275, 287, 282, 283, 286, 296, 324, 325, 326, 327, 367, 368, 369, 382, 383, 284, 285, 475, 474, 473, 493, 494, 496, 507, 520, 521, 522, 523, 571 ] }, { "id" : 4, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 709, "y" : 620 }, "minX" : 188, "maxX" : 1231, "minY" : 83, "maxY" : 1158, "prop" : { "x" : 188, "y" : 83, "width" : 1043, "height" : 1075 }, "textPosition" : { "x" : 212, "y" : 1110 }, "insets" : { "x" : 200, "y" : 91, "width" : 1020, "height" : 1056 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 5, 6, 7, 8, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 26, 27, 47, 65, 67, 114, 131, 132, 133, 136, 396, 397, 398, 399, 400, 401, 411, 413, 412, 414, 457, 466, 467, 468, 555, 556, 554, 574, 573, 572, 575, 576, 580, 975, 976, 977, 978, 1080 ] } ], "notes" : [ ], "links" : [ { "id" : 284, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1376, "y" : 412 }, "minX" : 1326, "maxX" : 1426, "minY" : 391, "maxY" : 434, "segments" : [ { "from" : { "x" : 1326, "y" : 391 }, "to" : { "x" : 1426, "y" : 434 } } ], "reactionShape" : { "a" : { "x" : 1370, "y" : 406 }, "b" : { "x" : 1382, "y" : 418 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1376, "y" : 412 } }, "inputs" : [ { "id" : 272 } ], "outputs" : [ { "id" : 283 } ] }, { "id" : 285, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1373, "y" : 473 }, "minX" : 1328, "maxX" : 1418, "minY" : 458, "maxY" : 488, "segments" : [ { "from" : { "x" : 1328, "y" : 488 }, "to" : { "x" : 1418, "y" : 458 } } ], "reactionShape" : { "a" : { "x" : 1367, "y" : 467 }, "b" : { "x" : 1379, "y" : 479 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1373, "y" : 473 } }, "inputs" : [ { "id" : 275 } ], "outputs" : [ { "id" : 283 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 1892, "minY" : 0, "maxY" : 1291, "disease" : false }