{ "dbId" : 8878159, "stId" : "R-HSA-8878159", "speciesName" : "Homo sapiens", "nodes" : [ { "dbId" : 8951432, "stId" : "R-HSA-8951432", "displayName" : "RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1330 ], "parents" : [ ], "children" : [ 8951429, 8865393 ] }, { "dbId" : 8878209, "stId" : "R-HSA-8878209", "displayName" : "JAG1 gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 605 ], "identifier" : "ENSG00000101384", "standardIdentifier" : "ensembl:ENSG00000101384", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "JAG1", "JAGL1" ], "parents" : [ 8878200 ], "children" : [ ] }, { "dbId" : 8951439, "stId" : "R-HSA-8951439", "displayName" : "CTNNB1:TCF7L2,LEF1 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1430 ], "parents" : [ 8853944 ], "children" : [ 3451168, 8853943 ] }, { "dbId" : 8951427, "stId" : "R-HSA-8951427", "displayName" : "TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "parents" : [ 8951429 ], "children" : [ 201923, 3214972, 5228649, 3299543 ] }, { "dbId" : 193545, "stId" : "R-HSA-193545", "displayName" : "CREBBP [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q92793", "standardIdentifier" : "uniprot:Q92793", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CREBBP", "CBP" ], "parents" : [ 1604462 ], "children" : [ ] }, { "dbId" : 8951429, "stId" : "R-HSA-8951429", "displayName" : "CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1329 ], "parents" : [ 8951432 ], "children" : [ 8951427, 3451168 ] }, { "dbId" : 2197548, "stId" : "R-HSA-2197548", "displayName" : "HES1 gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 739 ], "identifier" : "ENSG00000114315", "standardIdentifier" : "ensembl:ENSG00000114315", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "HES1", "BHLHB39", "HL", "HRY" ], "parents" : [ 8878239, 4396364 ], "children" : [ ] }, { "dbId" : 8878230, "stId" : "R-HSA-8878230", "displayName" : "RUNX3:NOTCH1 Coactivator Complex [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 697 ], "parents" : [ 8878239 ], "children" : [ 8865393, 1604462 ] }, { "dbId" : 8951964, "stId" : "R-HSA-8951964", "displayName" : "Ac-K94,K171-RUNX3:CBFB [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8952057, 8951959 ], "children" : [ 8865293, 8951965 ] }, { "dbId" : 8951965, "stId" : "R-HSA-8951965", "displayName" : "Ac-K94,K171-RUNX3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q13761", "standardIdentifier" : "uniprot:Q13761", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RUNX3", "AML2", "CBFA3", "PEBP2A3" ], "parents" : [ 8951964 ], "children" : [ ] }, { "dbId" : 178202, "stId" : "R-HSA-178202", "displayName" : "SMURF2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9HAU4", "standardIdentifier" : "uniprot:Q9HAU4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SMURF2" ], "parents" : [ 178205 ], "children" : [ ] }, { "dbId" : 8951952, "stId" : "R-HSA-8951952", "displayName" : "RUNX3:CBFB:EP300 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1862 ], "parents" : [ ], "children" : [ 381325, 8865463 ] }, { "dbId" : 8878239, "stId" : "R-HSA-8878239", "displayName" : "RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 740 ], "parents" : [ ], "children" : [ 2197548, 8878230 ] }, { "dbId" : 3006516, "stId" : "R-HSA-3006516", "displayName" : "KAT2A [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q92830", "standardIdentifier" : "uniprot:Q92830", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KAT2A", "GCN5", "GCN5L2" ], "parents" : [ 350078 ], "children" : [ ] }, { "dbId" : 178205, "stId" : "R-HSA-178205", "displayName" : "SMURF [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 2895 ], "parents" : [ ], "children" : [ 3004548, 178202 ] }, { "dbId" : 8951959, "stId" : "R-HSA-8951959", "displayName" : "Ac-K94,K171-RUNX3:CBFB:EP300 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1942 ], "parents" : [ 8951976 ], "children" : [ 381325, 8951964 ] }, { "dbId" : 8951976, "stId" : "R-HSA-8951976", "displayName" : "Ac-K94,K171-RUNX3:CBFB:EP300:BRD2 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2040 ], "parents" : [ 8952092 ], "children" : [ 8951959, 8951995 ] }, { "dbId" : 3200017, "stId" : "R-HSA-3200017", "displayName" : "CDKN2A gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2329 ], "identifier" : "ENSG00000147889", "standardIdentifier" : "ensembl:ENSG00000147889", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "CDKN2A", "CDKN2", "MLM" ], "parents" : [ 8952078 ], "children" : [ ] }, { "dbId" : 8951978, "stId" : "R-HSA-8951978", "displayName" : "KRAS:GTP [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2041 ], "parents" : [ ], "children" : [ 62719, 29438 ] }, { "dbId" : 8951979, "stId" : "R-HSA-8951979", "displayName" : "BRD2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P25440", "standardIdentifier" : "uniprot:P25440", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "BRD2", "KIAA9001", "RING3" ], "parents" : [ 8951995 ], "children" : [ ] }, { "dbId" : 5228649, "stId" : "R-HSA-5228649", "displayName" : "TCF7L1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9HCS4", "standardIdentifier" : "uniprot:Q9HCS4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TCF7L1", "TCF3" ], "parents" : [ 8951427, 8951530, 4411377 ], "children" : [ ] }, { "dbId" : 3786256, "stId" : "R-HSA-3786256", "displayName" : "CDKN1A gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 523 ], "identifier" : "ENSG00000124762", "standardIdentifier" : "ensembl:ENSG00000124762", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "CDKN1A", "CAP20", "CDKN1", "CIP1", "MDA6", "PIC1", "SDI1", "WAF1" ], "parents" : [ 8878180 ], "children" : [ ] }, { "dbId" : 8865463, "stId" : "R-HSA-8865463", "displayName" : "RUNX3:CBFB [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 517 ], "parents" : [ 8951907, 8952072, 8951952, 8949328, 8949278 ], "children" : [ 8865293, 8865393 ] }, { "dbId" : 8951995, "stId" : "R-HSA-8951995", "displayName" : "BRD2 homodimer [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2077 ], "parents" : [ 8952057, 8951976 ], "children" : [ 8951979 ] }, { "dbId" : 5649937, "stId" : "R-HSA-5649937", "displayName" : "CTGF gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1606 ], "identifier" : "ENSG00000118523", "standardIdentifier" : "ensembl:ENSG00000118523", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "CCN2", "CTGF", "HCS24", "IGFBP8" ], "parents" : [ 8951697 ], "children" : [ ] }, { "dbId" : 3214972, "stId" : "R-HSA-3214972", "displayName" : "LEF1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9UJU2", "standardIdentifier" : "uniprot:Q9UJU2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LEF1" ], "parents" : [ 8951512, 8951427, 8951530, 4411377, 8853943 ], "children" : [ ] }, { "dbId" : 8951512, "stId" : "R-HSA-8951512", "displayName" : "TCF7L2,(LEF1) [nucleoplasm]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "parents" : [ 8951514 ], "children" : [ 201923, 3214972 ] }, { "dbId" : 8951514, "stId" : "R-HSA-8951514", "displayName" : "RUNX3:CTNNB1:TCF7L2,(LEF1) [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1445 ], "parents" : [ ], "children" : [ 8865393, 8951512 ] }, { "dbId" : 177750, "stId" : "R-HSA-177750", "displayName" : "26S proteasome [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2825 ], "parents" : [ ], "children" : [ 9918350, 9918352 ] }, { "dbId" : 1629775, "stId" : "R-HSA-1629775", "displayName" : "WWTR1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9GZV5", "standardIdentifier" : "uniprot:Q9GZV5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "WWTR1", "TAZ" ], "parents" : [ 2032762 ], "children" : [ ] }, { "dbId" : 8948433, "stId" : "R-HSA-8948433", "displayName" : "RORC gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 955 ], "identifier" : "ENSG00000143365", "standardIdentifier" : "ensembl:ENSG00000143365", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "RORC", "NR1F3", "RORG", "RZRG" ], "parents" : [ 8949278 ], "children" : [ ] }, { "dbId" : 2032767, "stId" : "R-HSA-2032767", "displayName" : "TEAD3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q99594", "standardIdentifier" : "uniprot:Q99594", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TEAD3", "TEAD5", "TEF5" ], "parents" : [ 8951677, 8869638, 2032773 ], "children" : [ ] }, { "dbId" : 8951528, "stId" : "R-HSA-8951528", "displayName" : "RUNX3:TCF7L2,(LEF1,TCF7L1) [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1515 ], "parents" : [ ], "children" : [ 8865393, 8951530 ] }, { "dbId" : 8951530, "stId" : "R-HSA-8951530", "displayName" : "TCF7L2,(LEF1,TCF7L1) [nucleoplasm]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "parents" : [ 8951528 ], "children" : [ 201923, 3214972, 5228649 ] }, { "dbId" : 2032763, "stId" : "R-HSA-2032763", "displayName" : "TEAD2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q15562", "standardIdentifier" : "uniprot:Q15562", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TEAD2", "TEF4" ], "parents" : [ 8951677, 8869640, 2032773 ], "children" : [ ] }, { "dbId" : 2032762, "stId" : "R-HSA-2032762", "displayName" : "TEAD:WWTR1(TAZ) [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1623 ], "parents" : [ ], "children" : [ 2032773, 1629775 ] }, { "dbId" : 1629813, "stId" : "R-HSA-1629813", "displayName" : "p14ARF [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2716 ], "identifier" : "Q8N726", "standardIdentifier" : "uniprot:Q8N726", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CDKN2A", "CDKN2", "MLM" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8952057, "stId" : "R-HSA-8952057", "displayName" : "Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2189 ], "parents" : [ 8952063 ], "children" : [ 113832, 8951964, 8951995 ] }, { "dbId" : 8952063, "stId" : "R-HSA-8952063", "displayName" : "Ac-K94,K171-RUNX3:CBFB:BRD2:CCND1:HDAC4 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2243 ], "parents" : [ ], "children" : [ 351581, 8952057 ] }, { "dbId" : 8878084, "stId" : "R-HSA-8878084", "displayName" : "ZFHX3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 519 ], "identifier" : "Q15911", "standardIdentifier" : "uniprot:Q15911", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ZFHX3", "ATBF1", "C16orf47" ], "parents" : [ 8878120 ], "children" : [ ] }, { "dbId" : 8865295, "stId" : "R-HSA-8865295", "displayName" : "RUNX1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q01196", "standardIdentifier" : "uniprot:Q01196", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RUNX1", "AML1", "CBFA2" ], "parents" : [ 8865330 ], "children" : [ ] }, { "dbId" : 8865293, "stId" : "R-HSA-8865293", "displayName" : "CBFB [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 516 ], "identifier" : "Q13951", "standardIdentifier" : "uniprot:Q13951", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CBFB" ], "parents" : [ 8951964, 8865330, 8865463 ], "children" : [ ] }, { "dbId" : 199305, "stId" : "R-HSA-199305", "displayName" : "FOXO3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2579 ], "identifier" : "O43524", "standardIdentifier" : "uniprot:O43524", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "FOXO3", "FKHRL1", "FOXO3A" ], "parents" : [ 8952225 ], "children" : [ ] }, { "dbId" : 939164, "stId" : "R-HSA-939164", "displayName" : "UBC(77-152) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 2032780, "stId" : "R-HSA-2032780", "displayName" : "TEAD4 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q15561", "standardIdentifier" : "uniprot:Q15561", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TEAD4", "RTEF1", "TCF13L1", "TEF3" ], "parents" : [ 8951677, 8869641, 2032773 ], "children" : [ ] }, { "dbId" : 939165, "stId" : "R-HSA-939165", "displayName" : "UBC(609-684) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 8949278, "stId" : "R-HSA-8949278", "displayName" : "RUNX3:CBFB:RORC gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 956 ], "parents" : [ ], "children" : [ 8948433, 8865463 ] }, { "dbId" : 2032774, "stId" : "R-HSA-2032774", "displayName" : "TEAD1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P28347", "standardIdentifier" : "uniprot:P28347", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TEAD1", "TCF13", "TEF1" ], "parents" : [ 8951677, 8869643, 2032773 ], "children" : [ ] }, { "dbId" : 2032773, "stId" : "R-HSA-2032773", "displayName" : "TEADs [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 2032762 ], "children" : [ 2032774, 2032763, 2032780, 2032767 ] }, { "dbId" : 3004548, "stId" : "R-HSA-3004548", "displayName" : "SMURF1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9HCE7", "standardIdentifier" : "uniprot:Q9HCE7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SMURF1", "KIAA1625" ], "parents" : [ 178205 ], "children" : [ ] }, { "dbId" : 113832, "stId" : "R-HSA-113832", "displayName" : "CCND1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2188 ], "identifier" : "P24385", "standardIdentifier" : "uniprot:P24385", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CCND1", "BCL1", "PRAD1" ], "parents" : [ 8952072, 8952057 ], "children" : [ ] }, { "dbId" : 352430, "stId" : "R-HSA-352430", "displayName" : "KAT2B [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q92831", "standardIdentifier" : "uniprot:Q92831", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KAT2B", "PCAF" ], "parents" : [ 350078 ], "children" : [ ] }, { "dbId" : 8878120, "stId" : "R-HSA-8878120", "displayName" : "RUNX3:ZFHX3 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 520 ], "parents" : [ ], "children" : [ 8865393, 8878084 ] }, { "dbId" : 3008668, "stId" : "R-HSA-3008668", "displayName" : "RBPJ [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q06330", "standardIdentifier" : "uniprot:Q06330", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RBPJ", "IGKJRB", "IGKJRB1", "RBPJK", "RBPSUH" ], "parents" : [ 1604460 ], "children" : [ ] }, { "dbId" : 8949306, "stId" : "R-HSA-8949306", "displayName" : "RORC-2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1125 ], "identifier" : "P51449-2", "standardIdentifier" : "uniprot:P51449-2", "referenceType" : "ReferenceIsoform", "geneNames" : [ "RORC", "NR1F3", "RORG", "RZRG" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8865330, "stId" : "R-HSA-8865330", "displayName" : "RUNX1:CBFB [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8952092 ], "children" : [ 8865295, 8865293 ] }, { "dbId" : 939192, "stId" : "R-HSA-939192", "displayName" : "UBC(229-304) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 939191, "stId" : "R-HSA-939191", "displayName" : "UBC(381-456) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 939188, "stId" : "R-HSA-939188", "displayName" : "UBC(1-76) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 29370, "stId" : "R-ALL-29370", "displayName" : "ADP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 915 ], "identifier" : "456216", "standardIdentifier" : "chebi:456216", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 8952373, "stId" : "R-HSA-8952373", "displayName" : "RUNX3:p-S166,S188-MDM2 dimer [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2712 ], "parents" : [ ], "children" : [ 8865393, 6804933 ] }, { "dbId" : 939184, "stId" : "R-HSA-939184", "displayName" : "UBC(457-532) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 201923, "stId" : "R-HSA-201923", "displayName" : "TCF7L2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9NQB0", "standardIdentifier" : "uniprot:Q9NQB0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TCF7L2", "TCF4" ], "parents" : [ 8951512, 8951427, 8951530, 4411377, 8853943 ], "children" : [ ] }, { "dbId" : 939214, "stId" : "R-HSA-939214", "displayName" : "UBB(1-76) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 939213, "stId" : "R-HSA-939213", "displayName" : "UBB(77-152) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 8878146, "stId" : "R-HSA-8878146", "displayName" : "RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 527 ], "parents" : [ 8878180, 8952225 ], "children" : [ 8878153, 8865393 ] }, { "dbId" : 8949325, "stId" : "R-HSA-8949325", "displayName" : "ITGAL gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "ENSG00000005844", "standardIdentifier" : "ensembl:ENSG00000005844", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "ITGAL", "CD11A" ], "parents" : [ 8949354 ], "children" : [ ] }, { "dbId" : 939205, "stId" : "R-HSA-939205", "displayName" : "RPS27A(1-76) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62979", "standardIdentifier" : "uniprot:P62979", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RPS27A", "UBA80", "UBCEP1" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 8952387, "stId" : "R-HSA-8952387", "displayName" : "PolyUb-K94,K148-RUNX3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2715 ], "identifier" : "Q13761", "standardIdentifier" : "uniprot:Q13761", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RUNX3", "AML2", "CBFA3", "PEBP2A3" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 939203, "stId" : "R-HSA-939203", "displayName" : "UBA52(1-76) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62987", "standardIdentifier" : "uniprot:P62987", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBA52", "UBCEP2" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 8878153, "stId" : "R-HSA-8878153", "displayName" : "p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 526 ], "parents" : [ 8878146 ], "children" : [ 177103, 177104 ] }, { "dbId" : 939230, "stId" : "R-HSA-939230", "displayName" : "UBB(153-228) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 8952400, "stId" : "R-HSA-8952400", "displayName" : "PolyUb-K94,K148-RUNX3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2769 ], "identifier" : "Q13761", "standardIdentifier" : "uniprot:Q13761", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RUNX3", "AML2", "CBFA3", "PEBP2A3" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8949328, "stId" : "R-HSA-8949328", "displayName" : "RUNX3:CBFB:ITGAL gene,(ITGA4 gene) [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1228 ], "parents" : [ ], "children" : [ 8949354, 8865463 ] }, { "dbId" : 8951912, "stId" : "R-HSA-8951912", "displayName" : "RUNX1 gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1724 ], "identifier" : "ENSG00000159216", "standardIdentifier" : "ensembl:ENSG00000159216", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "RUNX1", "AML1", "CBFA2" ], "parents" : [ 8951907 ], "children" : [ ] }, { "dbId" : 8949353, "stId" : "R-HSA-8949353", "displayName" : "ITGAL,(ITGA4) [plasma membrane]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 1299 ], "parents" : [ ], "children" : [ 198013, 198007 ] }, { "dbId" : 8949354, "stId" : "R-HSA-8949354", "displayName" : "ITGAL gene,(ITGA4 gene) [nucleoplasm]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 1289 ], "parents" : [ 8949328 ], "children" : [ 8949325, 8949356 ] }, { "dbId" : 8878180, "stId" : "R-HSA-8878180", "displayName" : "RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4:CDKN1A gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 538 ], "parents" : [ ], "children" : [ 3786256, 8878146 ] }, { "dbId" : 8949356, "stId" : "R-HSA-8949356", "displayName" : "ITGA4 gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "ENSG00000115232", "standardIdentifier" : "ensembl:ENSG00000115232", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "ITGA4", "CD49D" ], "parents" : [ 8949354 ], "children" : [ ] }, { "dbId" : 3299543, "stId" : "R-HSA-3299543", "displayName" : "TCF7 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P36402", "standardIdentifier" : "uniprot:P36402", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TCF7", "TCF1" ], "parents" : [ 8951427 ], "children" : [ ] }, { "dbId" : 174311, "stId" : "R-HSA-174311", "displayName" : "PSMD2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q13200", "standardIdentifier" : "uniprot:Q13200", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD2", "TRAP2" ], "parents" : [ 9918364 ], "children" : [ ] }, { "dbId" : 174309, "stId" : "R-HSA-174309", "displayName" : "PSMD7 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P51665", "standardIdentifier" : "uniprot:P51665", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD7", "MOV34L" ], "parents" : [ 9918357 ], "children" : [ ] }, { "dbId" : 174314, "stId" : "R-HSA-174314", "displayName" : "PSMA6 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P60900", "standardIdentifier" : "uniprot:P60900", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA6", "PROS27" ], "parents" : [ 9918351 ], "children" : [ ] }, { "dbId" : 68328, "stId" : "R-HSA-68328", "displayName" : "CCND1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1390 ], "identifier" : "P24385", "standardIdentifier" : "uniprot:P24385", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CCND1", "BCL1", "PRAD1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 174315, "stId" : "R-HSA-174315", "displayName" : "PSMC4 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P43686", "standardIdentifier" : "uniprot:P43686", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMC4", "MIP224", "TBP7" ], "parents" : [ 9918349 ], "children" : [ ] }, { "dbId" : 939239, "stId" : "R-HSA-939239", "displayName" : "UBC(533-608) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 8952417, "stId" : "R-HSA-8952417", "displayName" : "PolyUb-RUNX3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2894 ], "identifier" : "Q13761", "standardIdentifier" : "uniprot:Q13761", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RUNX3", "AML2", "CBFA3", "PEBP2A3" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 174312, "stId" : "R-HSA-174312", "displayName" : "PSMC5 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62195", "standardIdentifier" : "uniprot:P62195", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMC5", "SUG1" ], "parents" : [ 9918349 ], "children" : [ ] }, { "dbId" : 8951907, "stId" : "R-HSA-8951907", "displayName" : "RUNX3:CBFB:RUNX1 gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1725 ], "parents" : [ ], "children" : [ 8951912, 8865463 ] }, { "dbId" : 174313, "stId" : "R-HSA-174313", "displayName" : "PSMC3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P17980", "standardIdentifier" : "uniprot:P17980", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMC3", "TBP1" ], "parents" : [ 9918362 ], "children" : [ ] }, { "dbId" : 174318, "stId" : "R-HSA-174318", "displayName" : "PSMD8 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P48556", "standardIdentifier" : "uniprot:P48556", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD8" ], "parents" : [ 9918358 ], "children" : [ ] }, { "dbId" : 174319, "stId" : "R-HSA-174319", "displayName" : "PSMC6 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62333", "standardIdentifier" : "uniprot:P62333", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMC6", "SUG2" ], "parents" : [ 9918362 ], "children" : [ ] }, { "dbId" : 174316, "stId" : "R-HSA-174316", "displayName" : "PSMD6 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q15008", "standardIdentifier" : "uniprot:Q15008", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD6", "KIAA0107", "PFAAP4" ], "parents" : [ 9918363 ], "children" : [ ] }, { "dbId" : 939232, "stId" : "R-HSA-939232", "displayName" : "UBC(305-380) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 1980143, "stId" : "R-HSA-1980143", "displayName" : "Signaling by NOTCH1", "schemaClass" : "Pathway", "speciesId" : 48887, "diagramIds" : [ 822 ] }, { "dbId" : 174323, "stId" : "R-HSA-174323", "displayName" : "PSMA3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P25788", "standardIdentifier" : "uniprot:P25788", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA3", "HC8", "PSC8" ], "parents" : [ 9918351 ], "children" : [ ] }, { "dbId" : 157939, "stId" : "R-HSA-157939", "displayName" : "NICD1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P46531", "standardIdentifier" : "uniprot:P46531", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NOTCH1", "TAN1" ], "parents" : [ 1604460 ], "children" : [ ] }, { "dbId" : 174326, "stId" : "R-HSA-174326", "displayName" : "PSMD13 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9UNM6", "standardIdentifier" : "uniprot:Q9UNM6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD13" ], "parents" : [ 9918357 ], "children" : [ ] }, { "dbId" : 939258, "stId" : "R-HSA-939258", "displayName" : "UBC(153-228) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 174327, "stId" : "R-HSA-174327", "displayName" : "PSMD11 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O00231", "standardIdentifier" : "uniprot:O00231", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD11" ], "parents" : [ 9918360 ], "children" : [ ] }, { "dbId" : 8865393, "stId" : "R-HSA-8865393", "displayName" : "RUNX3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 515 ], "identifier" : "Q13761", "standardIdentifier" : "uniprot:Q13761", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RUNX3", "AML2", "CBFA3", "PEBP2A3" ], "parents" : [ 8951514, 8952373, 8878230, 8878200, 8952123, 8878120, 8878146, 8951679, 8951432, 8951528, 8865463 ], "children" : [ ] }, { "dbId" : 174324, "stId" : "R-HSA-174324", "displayName" : "PSMA4 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P25789", "standardIdentifier" : "uniprot:P25789", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA4", "HC9", "PSC9" ], "parents" : [ 9918351 ], "children" : [ ] }, { "dbId" : 174331, "stId" : "R-HSA-174331", "displayName" : "PSMB7 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q99436", "standardIdentifier" : "uniprot:Q99436", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB7", "Z" ], "parents" : [ 9918354 ], "children" : [ ] }, { "dbId" : 174328, "stId" : "R-HSA-174328", "displayName" : "PSMD3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O43242", "standardIdentifier" : "uniprot:O43242", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD3" ], "parents" : [ 9918363 ], "children" : [ ] }, { "dbId" : 174329, "stId" : "R-HSA-174329", "displayName" : "PSMD14 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O00487", "standardIdentifier" : "uniprot:O00487", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD14", "POH1" ], "parents" : [ 9918357 ], "children" : [ ] }, { "dbId" : 8952436, "stId" : "R-HSA-8952436", "displayName" : "SPP1 gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2976 ], "identifier" : "ENSG00000118785", "standardIdentifier" : "ensembl:ENSG00000118785", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "SPP1", "BNSP", "OPN", "PSEC0156" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 174335, "stId" : "R-HSA-174335", "displayName" : "PSMB2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P49721", "standardIdentifier" : "uniprot:P49721", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB2" ], "parents" : [ 9918354 ], "children" : [ ] }, { "dbId" : 174332, "stId" : "R-HSA-174332", "displayName" : "PSMC2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P35998", "standardIdentifier" : "uniprot:P35998", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMC2", "MSS1" ], "parents" : [ 9918359 ], "children" : [ ] }, { "dbId" : 29438, "stId" : "R-ALL-29438", "displayName" : "GTP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "37565", "standardIdentifier" : "chebi:37565", "referenceType" : "ReferenceMolecule", "parents" : [ 8951978 ], "children" : [ ] }, { "dbId" : 174333, "stId" : "R-HSA-174333", "displayName" : "PSMA1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P25786", "standardIdentifier" : "uniprot:P25786", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA1", "HC2", "NU", "PROS30", "PSC2" ], "parents" : [ 9918351 ], "children" : [ ] }, { "dbId" : 62719, "stId" : "R-HSA-62719", "displayName" : "KRAS [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P01116", "standardIdentifier" : "uniprot:P01116", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KRAS", "KRAS2", "RASK2" ], "parents" : [ 8951978 ], "children" : [ ] }, { "dbId" : 8878200, "stId" : "R-HSA-8878200", "displayName" : "RUNX3:JAG1 gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 606 ], "parents" : [ ], "children" : [ 8865393, 8878209 ] }, { "dbId" : 9918359, "stId" : "R-HSA-9918359", "displayName" : "PSMC2:PSMC1 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9918364 ], "children" : [ 174332, 174338 ] }, { "dbId" : 174338, "stId" : "R-HSA-174338", "displayName" : "PSMC1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62191", "standardIdentifier" : "uniprot:P62191", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMC1" ], "parents" : [ 9918359 ], "children" : [ ] }, { "dbId" : 9918358, "stId" : "R-HSA-9918358", "displayName" : "19S RP lid [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9918350 ], "children" : [ 174318, 9918356 ] }, { "dbId" : 174339, "stId" : "R-HSA-174339", "displayName" : "PSMD12 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O00232", "standardIdentifier" : "uniprot:O00232", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD12" ], "parents" : [ 9918357 ], "children" : [ ] }, { "dbId" : 9918357, "stId" : "R-HSA-9918357", "displayName" : "PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9918360 ], "children" : [ 174329, 174309, 174326, 174339 ] }, { "dbId" : 9918356, "stId" : "R-HSA-9918356", "displayName" : "19S RP lid particle 2 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9918358 ], "children" : [ 9918360, 9918363 ] }, { "dbId" : 174342, "stId" : "R-HSA-174342", "displayName" : "PSMB6 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P28072", "standardIdentifier" : "uniprot:P28072", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB6", "LMPY", "Y" ], "parents" : [ 9918354 ], "children" : [ ] }, { "dbId" : 9918354, "stId" : "R-HSA-9918354", "displayName" : "20S CP inner ring [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9918352 ], "children" : [ 174335, 174344, 174331, 174347, 174341, 174343, 174342 ] }, { "dbId" : 174343, "stId" : "R-HSA-174343", "displayName" : "PSMB4 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P28070", "standardIdentifier" : "uniprot:P28070", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB4", "PROS26" ], "parents" : [ 9918354 ], "children" : [ ] }, { "dbId" : 174340, "stId" : "R-HSA-174340", "displayName" : "PSMA5 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P28066", "standardIdentifier" : "uniprot:P28066", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA5" ], "parents" : [ 9918351 ], "children" : [ ] }, { "dbId" : 9918353, "stId" : "R-HSA-9918353", "displayName" : "19S RP base [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9918350 ], "children" : [ 9918361, 174348, 9918362, 9918364, 9918349 ] }, { "dbId" : 9918352, "stId" : "R-HSA-9918352", "displayName" : "20S core particle [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 177750 ], "children" : [ 9918351, 9918354 ] }, { "dbId" : 174341, "stId" : "R-HSA-174341", "displayName" : "PSMB3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P49720", "standardIdentifier" : "uniprot:P49720", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB3" ], "parents" : [ 9918354 ], "children" : [ ] }, { "dbId" : 174347, "stId" : "R-HSA-174347", "displayName" : "PSMB1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P20618", "standardIdentifier" : "uniprot:P20618", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB1", "PSC5" ], "parents" : [ 9918354 ], "children" : [ ] }, { "dbId" : 174344, "stId" : "R-HSA-174344", "displayName" : "PSMB5 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P28074", "standardIdentifier" : "uniprot:P28074", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB5", "LMPX", "MB1", "X" ], "parents" : [ 9918354 ], "children" : [ ] }, { "dbId" : 174345, "stId" : "R-HSA-174345", "displayName" : "PSMA2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P25787", "standardIdentifier" : "uniprot:P25787", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA2", "HC3", "PSC3" ], "parents" : [ 9918351 ], "children" : [ ] }, { "dbId" : 9918364, "stId" : "R-HSA-9918364", "displayName" : "PSMC2:PSMC1:PSMD2 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9918353 ], "children" : [ 174311, 9918359 ] }, { "dbId" : 9918363, "stId" : "R-HSA-9918363", "displayName" : "19S RP lid particle 3 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9918356 ], "children" : [ 8866665, 174316, 174328 ] }, { "dbId" : 174351, "stId" : "R-HSA-174351", "displayName" : "PSMA7 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O14818", "standardIdentifier" : "uniprot:O14818", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA7", "HSPC" ], "parents" : [ 9918351 ], "children" : [ ] }, { "dbId" : 9918362, "stId" : "R-HSA-9918362", "displayName" : "PSMC3:PSMC6 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9918353 ], "children" : [ 174319, 174313 ] }, { "dbId" : 174348, "stId" : "R-HSA-174348", "displayName" : "PSMD1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q99460", "standardIdentifier" : "uniprot:Q99460", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD1" ], "parents" : [ 9918353 ], "children" : [ ] }, { "dbId" : 9918361, "stId" : "R-HSA-9918361", "displayName" : "ADRM1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q16186", "standardIdentifier" : "uniprot:Q16186", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ADRM1", "GP110" ], "parents" : [ 9918353 ], "children" : [ ] }, { "dbId" : 9918360, "stId" : "R-HSA-9918360", "displayName" : "19S RP Lid Module 1 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9918356 ], "children" : [ 174327, 9918357 ] }, { "dbId" : 4396364, "stId" : "R-HSA-4396364", "displayName" : "NOTCH1 Coactivator Complex:HES1 Gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 760 ], "parents" : [ ], "children" : [ 2197548, 1604462 ] }, { "dbId" : 3451168, "stId" : "R-HSA-3451168", "displayName" : "CTNNB1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P35222", "standardIdentifier" : "uniprot:P35222", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CTNNB1", "CTNNB", "OK/SW-cl.35", "PRO2286" ], "parents" : [ 8951439, 4411378, 8951429 ], "children" : [ ] }, { "dbId" : 9918351, "stId" : "R-HSA-9918351", "displayName" : "20S CP outer ring [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9918352 ], "children" : [ 174333, 174351, 174345, 174314, 174340, 174324, 174323 ] }, { "dbId" : 8951697, "stId" : "R-HSA-8951697", "displayName" : "TEADs:YAP1:CTGF gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1607 ], "parents" : [ ], "children" : [ 5649937, 8869639 ] }, { "dbId" : 9918350, "stId" : "R-HSA-9918350", "displayName" : "19S regulatory particle [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 177750 ], "children" : [ 9918353, 9918358 ] }, { "dbId" : 9918349, "stId" : "R-HSA-9918349", "displayName" : "PSMC4:PSMC5 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9918353 ], "children" : [ 174312, 174315 ] }, { "dbId" : 8952225, "stId" : "R-HSA-8952225", "displayName" : "RUNX3:p-2S-SMAD3:p-2S-SMAD3:SMAD4:FOXO3:BCL2L11 gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2540 ], "parents" : [ ], "children" : [ 199305, 8870688, 8878146 ] }, { "dbId" : 2485002, "stId" : "R-ALL-2485002", "displayName" : "CoA-SH [nucleoplasm]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 1943 ], "identifier" : "57287", "standardIdentifier" : "chebi:57287", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 8853943, "stId" : "R-HSA-8853943", "displayName" : "TCF7L2,LEF1 [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 8951439 ], "children" : [ 3214972, 201923 ] }, { "dbId" : 182585, "stId" : "R-HSA-182585", "displayName" : "CDKN1A [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 524 ], "identifier" : "P38936", "standardIdentifier" : "uniprot:P38936", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CDKN1A", "CAP20", "CDKN1", "CIP1", "MDA6", "PIC1", "SDI1", "WAF1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8853944, "stId" : "R-HSA-8853944", "displayName" : "CTNNB1:TCF7L2,LEF1:CCND1 Gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1391 ], "parents" : [ ], "children" : [ 8951439, 8853953 ] }, { "dbId" : 939854, "stId" : "R-HSA-939854", "displayName" : "UBB(153-228) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939853, "stId" : "R-HSA-939853", "displayName" : "UBC(153-228) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 8853953, "stId" : "R-HSA-8853953", "displayName" : "CCND1 gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1389 ], "identifier" : "ENSG00000110092", "standardIdentifier" : "ensembl:ENSG00000110092", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "CCND1", "BCL1", "PRAD1" ], "parents" : [ 8853944 ], "children" : [ ] }, { "dbId" : 939849, "stId" : "R-HSA-939849", "displayName" : "RPS27A(1-76) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62979", "standardIdentifier" : "uniprot:P62979", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RPS27A", "UBA80", "UBCEP1" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939847, "stId" : "R-HSA-939847", "displayName" : "UBB(1-76) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939844, "stId" : "R-HSA-939844", "displayName" : "UBA52(1-76) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62987", "standardIdentifier" : "uniprot:P62987", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBA52", "UBCEP2" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 170834, "stId" : "R-HSA-170834", "displayName" : "Signaling by TGF-beta Receptor Complex", "schemaClass" : "Pathway", "speciesId" : 48887, "diagramIds" : [ 530 ] }, { "dbId" : 939870, "stId" : "R-HSA-939870", "displayName" : "UBB(77-152) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939871, "stId" : "R-HSA-939871", "displayName" : "UBC(1-76) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939868, "stId" : "R-HSA-939868", "displayName" : "UBC(609-684) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939869, "stId" : "R-HSA-939869", "displayName" : "UBC(77-152) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939866, "stId" : "R-HSA-939866", "displayName" : "UBC(533-608) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 170838, "stId" : "R-HSA-170838", "displayName" : "TGFB1 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P01137", "standardIdentifier" : "uniprot:P01137", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TGFB1", "TGFB" ], "parents" : [ 170852 ], "children" : [ ] }, { "dbId" : 939862, "stId" : "R-HSA-939862", "displayName" : "UBC(457-532) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 351581, "stId" : "R-HSA-351581", "displayName" : "HDAC4 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2242 ], "identifier" : "P56524", "standardIdentifier" : "uniprot:P56524", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HDAC4", "KIAA0288" ], "parents" : [ 8952072, 8952063 ], "children" : [ ] }, { "dbId" : 939863, "stId" : "R-HSA-939863", "displayName" : "UBC(305-380) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939856, "stId" : "R-HSA-939856", "displayName" : "UBC(381-456) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939857, "stId" : "R-HSA-939857", "displayName" : "UBC(229-304) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 170852, "stId" : "R-HSA-170852", "displayName" : "Dimeric TGFB1 [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 521 ], "parents" : [ ], "children" : [ 170838 ] }, { "dbId" : 113518, "stId" : "R-ALL-113518", "displayName" : "H2O [nucleoplasm]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 2270 ], "identifier" : "15377", "standardIdentifier" : "chebi:15377", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 69488, "stId" : "R-HSA-69488", "displayName" : "TP53 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04637", "standardIdentifier" : "uniprot:P04637", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TP53", "P53" ], "parents" : [ 3209194 ], "children" : [ ] }, { "dbId" : 1604460, "stId" : "R-HSA-1604460", "displayName" : "NICD1:RBPJ:SNW1 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 1604462 ], "children" : [ 351663, 3008668, 157939 ] }, { "dbId" : 198007, "stId" : "R-HSA-198007", "displayName" : "ITGA4 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P13612", "standardIdentifier" : "uniprot:P13612", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ITGA4", "CD49D" ], "parents" : [ 8949353 ], "children" : [ ] }, { "dbId" : 1604462, "stId" : "R-HSA-1604462", "displayName" : "NOTCH1 Coactivator Complex [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 696 ], "parents" : [ 8878230, 4396364 ], "children" : [ 193545, 350078, 381325, 212357, 1604460 ] }, { "dbId" : 350078, "stId" : "R-HSA-350078", "displayName" : "PCAF [nucleoplasm]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "parents" : [ 1604462 ], "children" : [ 352430, 3006516 ] }, { "dbId" : 198013, "stId" : "R-HSA-198013", "displayName" : "ITGAL [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P20701", "standardIdentifier" : "uniprot:P20701", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ITGAL", "CD11A" ], "parents" : [ 8949353 ], "children" : [ ] }, { "dbId" : 8869639, "stId" : "R-HSA-8869639", "displayName" : "TEADs:YAP1 [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 1605 ], "parents" : [ 8951697 ], "children" : [ 8869640, 8869641, 8869643, 8869638 ] }, { "dbId" : 8952072, "stId" : "R-HSA-8952072", "displayName" : "RUNX3:CBFB:CCND1:HDAC4 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2262 ], "parents" : [ ], "children" : [ 113832, 351581, 8865463 ] }, { "dbId" : 8869638, "stId" : "R-HSA-8869638", "displayName" : "TEAD3:YAP1 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8869639 ], "children" : [ 1253322, 2032767 ] }, { "dbId" : 212353, "stId" : "R-HSA-212353", "displayName" : "MAML2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q8IZL2", "standardIdentifier" : "uniprot:Q8IZL2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MAML2", "KIAA1819" ], "parents" : [ 212357 ], "children" : [ ] }, { "dbId" : 8952078, "stId" : "R-HSA-8952078", "displayName" : "RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2):CDKN2A gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2330 ], "parents" : [ ], "children" : [ 8952092, 3200017 ] }, { "dbId" : 212357, "stId" : "R-HSA-212357", "displayName" : "MAML [nucleoplasm]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "parents" : [ 1604462 ], "children" : [ 349689, 212416, 212353, 349692 ] }, { "dbId" : 381325, "stId" : "R-HSA-381325", "displayName" : "EP300 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2897, 1861 ], "identifier" : "Q09472", "standardIdentifier" : "uniprot:Q09472", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "EP300", "P300" ], "parents" : [ 8951952, 8951959, 1604462 ], "children" : [ ] }, { "dbId" : 210825, "stId" : "R-HSA-210825", "displayName" : "HES1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 772 ], "identifier" : "Q14469", "standardIdentifier" : "uniprot:Q14469", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HES1", "BHLHB39", "HL", "HRY" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8869643, "stId" : "R-HSA-8869643", "displayName" : "TEAD1:YAP1 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8869639 ], "children" : [ 1253322, 2032774 ] }, { "dbId" : 2976673, "stId" : "R-HSA-2976673", "displayName" : "BCL2L11 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2563 ], "identifier" : "O43521", "standardIdentifier" : "uniprot:O43521", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "BCL2L11", "BIM" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8869641, "stId" : "R-HSA-8869641", "displayName" : "TEAD4:YAP1 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8869639 ], "children" : [ 1253322, 2032780 ] }, { "dbId" : 8869640, "stId" : "R-HSA-8869640", "displayName" : "TEAD2:YAP1 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8869639 ], "children" : [ 1253322, 2032763 ] }, { "dbId" : 8952092, "stId" : "R-HSA-8952092", "displayName" : "RUNX1:CBFB,(Ac-K94,K171-RUNX3:CBFB:EP300:BRD2) [nucleoplasm]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 2327 ], "parents" : [ 8952078 ], "children" : [ 8865330, 8951976 ] }, { "dbId" : 113560, "stId" : "R-ALL-113560", "displayName" : "Ac-CoA [nucleoplasm]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 1941 ], "identifier" : "57288", "standardIdentifier" : "chebi:57288", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 215967, "stId" : "R-HSA-215967", "displayName" : "SPP1 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2977 ], "identifier" : "P10451", "standardIdentifier" : "uniprot:P10451", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SPP1", "BNSP", "OPN", "PSEC0156" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 6804933, "stId" : "R-HSA-6804933", "displayName" : "p-S166,S188-MDM2 dimer [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2711 ], "parents" : [ 8952373 ], "children" : [ 6793669 ] }, { "dbId" : 6793669, "stId" : "R-HSA-6793669", "displayName" : "p-S166,S188-MDM2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q00987", "standardIdentifier" : "uniprot:Q00987", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MDM2" ], "parents" : [ 6804933 ], "children" : [ ] }, { "dbId" : 3209107, "stId" : "R-HSA-3209107", "displayName" : "p14ARF mRNA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2383 ], "identifier" : "ENST00000579755", "standardIdentifier" : "ensembl:ENST00000579755", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "CDKN2A" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8870688, "stId" : "R-HSA-8870688", "displayName" : "BCL2L11 gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2539 ], "identifier" : "ENSG00000153094", "standardIdentifier" : "ensembl:ENSG00000153094", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "BCL2L11", "BIM" ], "parents" : [ 8952225 ], "children" : [ ] }, { "dbId" : 157098, "stId" : "R-HSA-157098", "displayName" : "JAG1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 664 ], "identifier" : "P78504", "standardIdentifier" : "uniprot:P78504", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "JAG1", "JAGL1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 351663, "stId" : "R-HSA-351663", "displayName" : "SNW1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q13573", "standardIdentifier" : "uniprot:Q13573", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SNW1", "SKIIP", "SKIP" ], "parents" : [ 1604460 ], "children" : [ ] }, { "dbId" : 68524, "stId" : "R-HSA-68524", "displayName" : "Ub [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 2979 ], "parents" : [ ], "children" : [ 939854, 939853, 939849, 939847, 939844, 939870, 939871, 939868, 939869, 939866, 939862, 939863, 939856, 939857 ] }, { "dbId" : 4411378, "stId" : "R-HSA-4411378", "displayName" : "TCF7L1/TCF7L2/LEF1:CTNNB1 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1448 ], "parents" : [ 4411387 ], "children" : [ 3451168, 4411377 ] }, { "dbId" : 4411377, "stId" : "R-HSA-4411377", "displayName" : "TCF7L1/TCF7L2/LEF1 [nucleoplasm]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "parents" : [ 4411378 ], "children" : [ 3214972, 5228649, 201923 ] }, { "dbId" : 8952123, "stId" : "R-HSA-8952123", "displayName" : "RUNX3:TP53 tetramer [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2414 ], "parents" : [ ], "children" : [ 3209194, 8865393 ] }, { "dbId" : 2127254, "stId" : "R-HSA-2127254", "displayName" : "MYC gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1447 ], "identifier" : "ENSG00000136997", "standardIdentifier" : "ensembl:ENSG00000136997", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "MYC", "BHLHE39" ], "parents" : [ 4411387 ], "children" : [ ] }, { "dbId" : 4411387, "stId" : "R-HSA-4411387", "displayName" : "TCF7L1/TCF7L2/LEF1:CTNNB1:MYC gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1449 ], "parents" : [ ], "children" : [ 2127254, 4411378 ] }, { "dbId" : 113592, "stId" : "R-ALL-113592", "displayName" : "ATP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 904 ], "identifier" : "30616", "standardIdentifier" : "chebi:30616", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 113595, "stId" : "R-HSA-113595", "displayName" : "Ub [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 2824 ], "parents" : [ ], "children" : [ 939214, 939213, 939239, 939205, 939203, 939232, 939230, 939164, 939165, 939258, 939192, 939191, 939188, 939184 ] }, { "dbId" : 212416, "stId" : "R-HSA-212416", "displayName" : "MAML1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q92585", "standardIdentifier" : "uniprot:Q92585", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MAML1", "KIAA0200" ], "parents" : [ 212357 ], "children" : [ ] }, { "dbId" : 8937805, "stId" : "R-HSA-8937805", "displayName" : "p-Y-RUNX3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 905 ], "identifier" : "Q13761", "standardIdentifier" : "uniprot:Q13761", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RUNX3", "AML2", "CBFA3", "PEBP2A3" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8937795, "stId" : "R-HSA-8937795", "displayName" : "MyrG-p-Y419-SRC:RUNX3 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 849 ], "parents" : [ ], "children" : [ 8937797, 1810408 ] }, { "dbId" : 8937797, "stId" : "R-HSA-8937797", "displayName" : "RUNX3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 848 ], "identifier" : "Q13761", "standardIdentifier" : "uniprot:Q13761", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RUNX3", "AML2", "CBFA3", "PEBP2A3" ], "parents" : [ 8937795 ], "children" : [ ] }, { "dbId" : 177103, "stId" : "R-HSA-177103", "displayName" : "SMAD4 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q13485", "standardIdentifier" : "uniprot:Q13485", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SMAD4", "DPC4", "MADH4" ], "parents" : [ 8878153 ], "children" : [ ] }, { "dbId" : 177104, "stId" : "R-HSA-177104", "displayName" : "p-S423,S425-SMAD3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P84022", "standardIdentifier" : "uniprot:P84022", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SMAD3", "MADH3" ], "parents" : [ 8878153 ], "children" : [ ] }, { "dbId" : 427486, "stId" : "R-ALL-427486", "displayName" : "CH3COO- [nucleoplasm]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 2271 ], "identifier" : "15366", "standardIdentifier" : "chebi:15366", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 1253322, "stId" : "R-HSA-1253322", "displayName" : "YAP1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P46937", "standardIdentifier" : "uniprot:P46937", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "YAP1", "YAP65" ], "parents" : [ 8951678, 8869638, 8869640, 8869643, 8869641 ], "children" : [ ] }, { "dbId" : 188379, "stId" : "R-HSA-188379", "displayName" : "MYC [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2978 ], "identifier" : "P01106", "standardIdentifier" : "uniprot:P01106", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MYC", "BHLHE39" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 3209194, "stId" : "R-HSA-3209194", "displayName" : "TP53 Tetramer [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 2413 ], "parents" : [ 8952123 ], "children" : [ 69488 ] }, { "dbId" : 8935779, "stId" : "R-HSA-8935779", "displayName" : "RUNX1 mRNA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1743 ], "identifier" : "ENST00000344691", "standardIdentifier" : "ensembl:ENST00000344691", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "RUNX1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8866665, "stId" : "R-HSA-8866665", "displayName" : "SEM1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P60896", "standardIdentifier" : "uniprot:P60896", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SEM1", "C7orf76", "DSS1", "SHFDG1", "SHFM1" ], "parents" : [ 9918363 ], "children" : [ ] }, { "dbId" : 1810408, "stId" : "R-HSA-1810408", "displayName" : "MyrG-p-Y419-SRC [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 847 ], "identifier" : "P12931", "standardIdentifier" : "uniprot:P12931", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SRC", "SRC1" ], "parents" : [ 8937795 ], "children" : [ ] }, { "dbId" : 561148, "stId" : "R-HSA-561148", "displayName" : "CTGF [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1621 ], "identifier" : "P29279", "standardIdentifier" : "uniprot:P29279", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CCN2", "CTGF", "HCS24", "IGFBP8" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8951677, "stId" : "R-HSA-8951677", "displayName" : "TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "parents" : [ 8951678 ], "children" : [ 2032774, 2032780, 2032763, 2032767 ] }, { "dbId" : 8951678, "stId" : "R-HSA-8951678", "displayName" : "YAP1:TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1547 ], "parents" : [ 8951679 ], "children" : [ 1253322, 8951677 ] }, { "dbId" : 8951679, "stId" : "R-HSA-8951679", "displayName" : "RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1548 ], "parents" : [ ], "children" : [ 8865393, 8951678 ] }, { "dbId" : 349692, "stId" : "R-HSA-349692", "displayName" : "MAMLD1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q13495", "standardIdentifier" : "uniprot:Q13495", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MAMLD1", "CG1", "CXorf6" ], "parents" : [ 212357 ], "children" : [ ] }, { "dbId" : 349689, "stId" : "R-HSA-349689", "displayName" : "MAML3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q96JK9", "standardIdentifier" : "uniprot:Q96JK9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MAML3", "KIAA1816" ], "parents" : [ 212357 ], "children" : [ ] } ], "edges" : [ { "dbId" : 8878212, "stId" : "R-HSA-8878212", "displayName" : "JAG1 gene expression is inhibited by RUNX3", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8878193 ], "inputs" : [ 8878209 ], "outputs" : [ 157098 ], "efs" : [ ], "inhibitors" : [ 8878200 ], "diagramIds" : [ 663 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8951695, "stId" : "R-HSA-8951695", "displayName" : "TEADs:YAP1 binds CTGF gene", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8951676 ], "following" : [ 1989766 ], "inputs" : [ 5649937, 8869639 ], "outputs" : [ 8951697 ], "efs" : [ ], "inhibitors" : [ 8951679 ], "diagramIds" : [ 1604 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8937807, "stId" : "R-HSA-8937807", "displayName" : "SRC phosphorylates RUNX3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8937792 ], "inputs" : [ 8937795, 113592 ], "outputs" : [ 29370, 8937805, 1810408 ], "catalysts" : [ 8937795 ], "efs" : [ ], "diagramIds" : [ 903 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952399, "stId" : "R-HSA-8952399", "displayName" : "Polyubiquitinated RUNX3 translocates to the cytosol", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8952382 ], "following" : [ 8952408 ], "inputs" : [ 8952387 ], "outputs" : [ 8952400 ], "efs" : [ ], "diagramIds" : [ 2768 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8951951, "stId" : "R-HSA-8951951", "displayName" : "RUNX3 binds EP300", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8865454 ], "following" : [ 8951966 ], "inputs" : [ 381325, 8865463 ], "outputs" : [ 8951952 ], "efs" : [ ], "diagramIds" : [ 1860 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8937792, "stId" : "R-HSA-8937792", "displayName" : "RUNX3 binds SRC", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8937807 ], "inputs" : [ 8937797, 1810408 ], "outputs" : [ 8937795 ], "efs" : [ ], "diagramIds" : [ 846 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952128, "stId" : "R-HSA-8952128", "displayName" : "RUNX3 binds TP53", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8937814 ], "inputs" : [ 3209194, 8865393 ], "outputs" : [ 8952123 ], "efs" : [ ], "diagramIds" : [ 2412 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8878220, "stId" : "R-HSA-8878220", "displayName" : "RUNX3 binds the NOTCH1 coactivator complex", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8937814 ], "following" : [ 8878237 ], "inputs" : [ 1604462, 8865393 ], "outputs" : [ 8878230 ], "efs" : [ ], "diagramIds" : [ 695 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8951428, "stId" : "R-HSA-8951428", "displayName" : "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8937814 ], "following" : [ 8951442, 4411367 ], "inputs" : [ 8951429, 8865393 ], "outputs" : [ 8951432 ], "efs" : [ ], "diagramIds" : [ 1328 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952069, "stId" : "R-HSA-8952069", "displayName" : "HDAC4 deacetylates RUNX3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8952062 ], "inputs" : [ 113518, 8952063 ], "outputs" : [ 427486, 8951995, 8952072 ], "catalysts" : [ 8952063 ], "efs" : [ ], "diagramIds" : [ 2261 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952408, "stId" : "R-HSA-8952408", "displayName" : "Polyubiquitinated RUNX3 is degraded by the proteasome", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8952399 ], "inputs" : [ 8952400 ], "outputs" : [ 113595 ], "catalysts" : [ 177750 ], "efs" : [ ], "diagramIds" : [ 2823 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 1980047, "stId" : "R-HSA-1980047", "displayName" : "NOTCH1 stimulates HES1 transcription", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 4396347 ], "inputs" : [ 2197548 ], "outputs" : [ 210825 ], "efs" : [ ], "activators" : [ 4396364 ], "diagramIds" : [ 771 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8949276, "stId" : "R-HSA-8949276", "displayName" : "RUNX3:CBFB binds the RORC gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8865454 ], "following" : [ 8949301 ], "inputs" : [ 8948433, 8865463 ], "outputs" : [ 8949278 ], "efs" : [ ], "diagramIds" : [ 954 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8951966, "stId" : "R-HSA-8951966", "displayName" : "EP300 acetylates RUNX3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8951951 ], "following" : [ 8951977 ], "inputs" : [ 113560, 8951952 ], "outputs" : [ 2485002, 8951959 ], "catalysts" : [ 8951952 ], "efs" : [ ], "activators" : [ 170852 ], "diagramIds" : [ 1940 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8949343, "stId" : "R-HSA-8949343", "displayName" : "ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8949335 ], "inputs" : [ 8949354 ], "outputs" : [ 8949353 ], "efs" : [ ], "activators" : [ 8949328 ], "diagramIds" : [ 1250 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 1989766, "stId" : "R-HSA-1989766", "displayName" : "Expression of CTGF", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8951695 ], "inputs" : [ 5649937 ], "outputs" : [ 561148 ], "efs" : [ ], "activators" : [ 8869639, 2032762 ], "diagramIds" : [ 1620 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952081, "stId" : "R-HSA-8952081", "displayName" : "RUNX proteins bind the p14-ARF promoter at the CDKN2A locus", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8951977 ], "following" : [ 8952101 ], "inputs" : [ 8952092, 3200017 ], "outputs" : [ 8952078 ], "efs" : [ ], "diagramIds" : [ 2326 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8951442, "stId" : "R-HSA-8951442", "displayName" : "CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8951428 ], "following" : [ 8951443 ], "inputs" : [ 8951439, 8853953 ], "outputs" : [ 8853944 ], "efs" : [ ], "inhibitors" : [ 8951514 ], "diagramIds" : [ 1429 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8878237, "stId" : "R-HSA-8878237", "displayName" : "RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8878220 ], "following" : [ 8878243 ], "inputs" : [ 2197548, 8878230 ], "outputs" : [ 8878239 ], "efs" : [ ], "diagramIds" : [ 738 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8951443, "stId" : "R-HSA-8951443", "displayName" : "Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8951442 ], "inputs" : [ 8853953 ], "outputs" : [ 68328 ], "efs" : [ ], "activators" : [ 8853944 ], "diagramIds" : [ 1421 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 4411357, "stId" : "R-HSA-4411357", "displayName" : "TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 4411367 ], "inputs" : [ 2127254 ], "outputs" : [ 188379 ], "efs" : [ ], "activators" : [ 4411387 ], "diagramIds" : [ 1581 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8937814, "stId" : "R-HSA-8937814", "displayName" : "RUNX3 translocates to the nucleus", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8952419, 8952371, 8878220, 8878193, 8952128, 8878117, 8878143, 8865454, 8951676, 8951428 ], "inputs" : [ 8937797 ], "outputs" : [ 8865393 ], "efs" : [ ], "inhibitors" : [ 1810408 ], "activators" : [ 170852 ], "diagramIds" : [ 946 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8949335, "stId" : "R-HSA-8949335", "displayName" : "RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8865454 ], "following" : [ 8949343 ], "inputs" : [ 8949354, 8865463 ], "outputs" : [ 8949328 ], "efs" : [ ], "diagramIds" : [ 1226 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952232, "stId" : "R-HSA-8952232", "displayName" : "BCL2L11 (BIM) gene transcription is stimulated by RUNX3", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8952226 ], "inputs" : [ 8870688 ], "outputs" : [ 2976673 ], "efs" : [ ], "activators" : [ 8952225 ], "diagramIds" : [ 2562 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8951977, "stId" : "R-HSA-8951977", "displayName" : "Acetylated RUNX3 binds to BRD2", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8951966 ], "following" : [ 8952081, 8952058 ], "inputs" : [ 8951959, 8951995 ], "outputs" : [ 8951976 ], "efs" : [ ], "activators" : [ 8951978 ], "diagramIds" : [ 2038 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8878117, "stId" : "R-HSA-8878117", "displayName" : "RUNX3 binds ZFHX3", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8937814 ], "following" : [ 8878130 ], "inputs" : [ 8865393, 8878084 ], "outputs" : [ 8878120 ], "efs" : [ ], "activators" : [ 170852 ], "diagramIds" : [ 518 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 4411367, "stId" : "R-HSA-4411367", "displayName" : "TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8951428 ], "following" : [ 4411357 ], "inputs" : [ 2127254, 4411378 ], "outputs" : [ 4411387 ], "efs" : [ ], "inhibitors" : [ 8951528 ], "diagramIds" : [ 1446 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8878243, "stId" : "R-HSA-8878243", "displayName" : "HES1 gene transcription is inhibited by RUNX3", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8878237 ], "inputs" : [ 2197548 ], "outputs" : [ 210825 ], "efs" : [ ], "inhibitors" : [ 8878239 ], "diagramIds" : [ 795 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8878178, "stId" : "R-HSA-8878178", "displayName" : "The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8878143 ], "following" : [ 8878186 ], "inputs" : [ 3786256, 8878146 ], "outputs" : [ 8878180 ], "efs" : [ ], "diagramIds" : [ 537 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8865454, "stId" : "R-HSA-8865454", "displayName" : "CBFB binds RUNX3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8937814 ], "following" : [ 8951910, 8951951, 8949335, 8949276, 8952442 ], "inputs" : [ 8865293, 8865393 ], "outputs" : [ 8865463 ], "efs" : [ ], "diagramIds" : [ 514 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952226, "stId" : "R-HSA-8952226", "displayName" : "RUNX3 binds the BCL2L11 (BIM) gene", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8878143 ], "following" : [ 8952232 ], "inputs" : [ 199305, 8870688, 8878146 ], "outputs" : [ 8952225 ], "efs" : [ ], "diagramIds" : [ 2538 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952419, "stId" : "R-HSA-8952419", "displayName" : "SMURFs ubiquitinate RUNX3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8937814 ], "inputs" : [ 68524, 8865393 ], "outputs" : [ 8952417 ], "catalysts" : [ 178205 ], "efs" : [ ], "inhibitors" : [ 381325 ], "diagramIds" : [ 2893 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952101, "stId" : "R-HSA-8952101", "displayName" : "p14-ARF transcription is stimulated by RUNX proteins", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8952081 ], "inputs" : [ 3200017 ], "outputs" : [ 3209107 ], "efs" : [ ], "activators" : [ 8952078 ], "diagramIds" : [ 2382 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8878186, "stId" : "R-HSA-8878186", "displayName" : "CDKN1A gene expression is synergistically activated by RUNX3, SMAD3 and SMAD4", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8878178 ], "inputs" : [ 3786256 ], "outputs" : [ 182585 ], "efs" : [ ], "activators" : [ 8878180 ], "diagramIds" : [ 573 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8951910, "stId" : "R-HSA-8951910", "displayName" : "RUNX3 binds the RUNX1 promoter", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8865454 ], "following" : [ 8951926 ], "inputs" : [ 8951912, 8865463 ], "outputs" : [ 8951907 ], "efs" : [ ], "diagramIds" : [ 1723 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952058, "stId" : "R-HSA-8952058", "displayName" : "CCND1 binds RUNX3 and displaces EP300", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8951977 ], "following" : [ 8952062 ], "inputs" : [ 113832, 8951976 ], "outputs" : [ 381325, 8952057 ], "efs" : [ ], "diagramIds" : [ 2187 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952442, "stId" : "R-HSA-8952442", "displayName" : "SPP1 gene expression is stimulated by RUNX3", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8865454 ], "inputs" : [ 8952436 ], "outputs" : [ 215967 ], "efs" : [ ], "activators" : [ 8865463 ], "diagramIds" : [ 2975 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8951676, "stId" : "R-HSA-8951676", "displayName" : "RUNX3 binds TEADs and YAP1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8937814 ], "following" : [ 8951695 ], "inputs" : [ 8951678, 8865393 ], "outputs" : [ 8951679 ], "efs" : [ ], "diagramIds" : [ 1546 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8878130, "stId" : "R-HSA-8878130", "displayName" : "CDKN1A (p21) gene expression is positively regulated by RUNX3 and ZFHX3", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8878117 ], "inputs" : [ 3786256 ], "outputs" : [ 182585 ], "efs" : [ ], "activators" : [ 8878120 ], "diagramIds" : [ 522 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952382, "stId" : "R-HSA-8952382", "displayName" : "MDM2 polyubiquitinates RUNX3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8952371 ], "following" : [ 8952399 ], "inputs" : [ 68524, 8952373 ], "outputs" : [ 8952387, 6804933 ], "catalysts" : [ 8952373 ], "efs" : [ ], "inhibitors" : [ 1629813 ], "diagramIds" : [ 2713 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952062, "stId" : "R-HSA-8952062", "displayName" : "CCND1 recruits HDAC4 to RUNX3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8952058 ], "following" : [ 8952069 ], "inputs" : [ 351581, 8952057 ], "outputs" : [ 8952063 ], "efs" : [ ], "diagramIds" : [ 2241 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8878193, "stId" : "R-HSA-8878193", "displayName" : "RUNX3 binds the JAG1 gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8937814 ], "following" : [ 8878212 ], "inputs" : [ 8878209, 8865393 ], "outputs" : [ 8878200 ], "efs" : [ ], "diagramIds" : [ 604 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 4396347, "stId" : "R-HSA-4396347", "displayName" : "NOTCH1 Coactivator Complex binds HES1 promoter", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 1980047 ], "inputs" : [ 2197548, 1604462 ], "outputs" : [ 4396364 ], "efs" : [ ], "diagramIds" : [ 759 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8878143, "stId" : "R-HSA-8878143", "displayName" : "RUNX3 binds SMAD3 and SMAD4", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8937814 ], "following" : [ 8878178, 8952226 ], "inputs" : [ 8878153, 8865393 ], "outputs" : [ 8878146 ], "efs" : [ ], "diagramIds" : [ 525 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8952371, "stId" : "R-HSA-8952371", "displayName" : "MDM2 binds RUNX3", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8937814 ], "following" : [ 8952382 ], "inputs" : [ 8865393, 6804933 ], "outputs" : [ 8952373 ], "efs" : [ ], "diagramIds" : [ 2710 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8949301, "stId" : "R-HSA-8949301", "displayName" : "RORC gene expression is stimulated by RUNX3:CBFB", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8949276 ], "inputs" : [ 8948433 ], "outputs" : [ 8949306 ], "efs" : [ ], "activators" : [ 8949278 ], "diagramIds" : [ 1124 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8951926, "stId" : "R-HSA-8951926", "displayName" : "RUNX1 gene expression is inhibited by RUNX3", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8951910 ], "inputs" : [ 8951912 ], "outputs" : [ 8935779 ], "efs" : [ ], "inhibitors" : [ 8951907 ], "diagramIds" : [ 1742 ], "entityFunctionalStatus" : [ ] } ], "subpathways" : [ { "dbId" : 8952158, "stId" : "R-HSA-8952158", "displayName" : "RUNX3 regulates BCL2L11 (BIM) transcription", "events" : [ 8952232, 8952226 ] }, { "dbId" : 8951430, "stId" : "R-HSA-8951430", "displayName" : "RUNX3 regulates WNT signaling", "events" : [ 4411367, 8951442, 8951443, 8951428, 4411357 ] }, { "dbId" : 8951936, "stId" : "R-HSA-8951936", "displayName" : "RUNX3 regulates p14-ARF", "events" : [ 8951977, 8952058, 8951966, 8952062, 8951951, 8952081, 8952101, 8952069 ] }, { "dbId" : 8951911, "stId" : "R-HSA-8951911", "displayName" : "RUNX3 regulates RUNX1-mediated transcription", "events" : [ 8951910, 8951926 ] }, { "dbId" : 8941858, "stId" : "R-HSA-8941858", "displayName" : "Regulation of RUNX3 expression and activity", "events" : [ 8952408, 8952382, 8937807, 8952399, 8937792, 8865454, 8952371, 8952419, 8937814 ] }, { "dbId" : 8941856, "stId" : "R-HSA-8941856", "displayName" : "RUNX3 regulates NOTCH signaling", "events" : [ 1980047, 8878212, 8878243, 8878193, 4396347, 8878237, 8878220 ] }, { "dbId" : 8951671, "stId" : "R-HSA-8951671", "displayName" : "RUNX3 regulates YAP1-mediated transcription", "events" : [ 8951676, 8951695, 1989766 ] }, { "dbId" : 8949275, "stId" : "R-HSA-8949275", "displayName" : "RUNX3 Regulates Immune Response and Cell Migration", "events" : [ 8952442, 8949276, 8949343, 8949301, 8949335 ] }, { "dbId" : 8941855, "stId" : "R-HSA-8941855", "displayName" : "RUNX3 regulates CDKN1A transcription", "events" : [ 8878117, 8878178, 8878130, 8878143, 8952128, 8878186 ] } ] }