{
  "dbId" : 75205,
  "stableId" : "R-HSA-75205",
  "displayName" : "Dissolution of Fibrin Clot",
  "nodes" : [ {
    "id" : 66,
    "reactomeId" : 158745,
    "displayName" : "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 981,
      "y" : 560
    },
    "minX" : 643,
    "maxX" : 1191,
    "minY" : 522,
    "maxY" : 666,
    "prop" : {
      "x" : 917,
      "y" : 528,
      "width" : 129,
      "height" : 64
    },
    "textPosition" : {
      "x" : 919,
      "y" : 515
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1046,
          "y" : 528
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1046,
          "y" : 528
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 65,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1049,
          "y" : 578
        },
        "to" : {
          "x" : 1191,
          "y" : 619
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 90,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 981,
          "y" : 595
        },
        "to" : {
          "x" : 981,
          "y" : 666
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 985,
          "y" : 602
        },
        "b" : {
          "x" : 981,
          "y" : 595
        },
        "c" : {
          "x" : 977,
          "y" : 602
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 977,
          "y" : 602
        }
      }
    }, {
      "edgeId" : 63,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 914,
          "y" : 578
        },
        "to" : {
          "x" : 643,
          "y" : 659
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 67,
    "reactomeId" : 157771,
    "displayName" : "fibrin multimer, crosslinked",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 673,
      "y" : 190
    },
    "minX" : 624,
    "maxX" : 789,
    "minY" : 172,
    "maxY" : 208,
    "prop" : {
      "x" : 624,
      "y" : 172,
      "width" : 99,
      "height" : 36
    },
    "textPosition" : {
      "x" : 634,
      "y" : 166
    },
    "connectors" : [ {
      "edgeId" : 80,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 88,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 726,
          "y" : 189
        },
        "to" : {
          "x" : 789,
          "y" : 189
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 131,
    "reactomeId" : 9724734,
    "displayName" : "anti-fibrinolytics",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 1164,
      "y" : 224
    },
    "minX" : 1120,
    "maxX" : 1202,
    "minY" : 208,
    "maxY" : 315,
    "prop" : {
      "x" : 1126,
      "y" : 208,
      "width" : 76,
      "height" : 32
    },
    "textPosition" : {
      "x" : 1128,
      "y" : 200
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 130,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1156,
          "y" : 246
        },
        "to" : {
          "x" : 1120,
          "y" : 315
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 68,
    "reactomeId" : 158791,
    "displayName" : "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 847,
      "y" : 814
    },
    "minX" : 786,
    "maxX" : 914,
    "minY" : 762,
    "maxY" : 860,
    "prop" : {
      "x" : 786,
      "y" : 768,
      "width" : 122,
      "height" : 92
    },
    "textPosition" : {
      "x" : 785,
      "y" : 741
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 908,
          "y" : 768
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 908,
          "y" : 768
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 74,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 132,
    "reactomeId" : 9724729,
    "displayName" : "PLG(20-810):anti-fibrinolytics",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 1053,
      "y" : 263
    },
    "minX" : 998,
    "maxX" : 1114,
    "minY" : 239,
    "maxY" : 281,
    "prop" : {
      "x" : 998,
      "y" : 245,
      "width" : 110,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1000,
      "y" : 246
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1108,
          "y" : 245
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1108,
          "y" : 245
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 130,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 135,
    "reactomeId" : 9724743,
    "displayName" : "aprotinin",
    "schemaClass" : "ProteinDrug",
    "renderableClass" : "ProteinDrug",
    "position" : {
      "x" : 1380,
      "y" : 472
    },
    "isDisease" : true,
    "minX" : 1309,
    "maxX" : 1416,
    "minY" : 409,
    "maxY" : 485,
    "prop" : {
      "x" : 1344,
      "y" : 460,
      "width" : 72,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1348,
      "y" : 462
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 134,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1365,
          "y" : 457
        },
        "to" : {
          "x" : 1309,
          "y" : 409
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 136,
    "reactomeId" : 9724726,
    "displayName" : "PLG(20-810):aprotinin",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 1325,
      "y" : 332
    },
    "minX" : 1278,
    "maxX" : 1378,
    "minY" : 309,
    "maxY" : 350,
    "prop" : {
      "x" : 1278,
      "y" : 315,
      "width" : 94,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1280,
      "y" : 315
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1372,
          "y" : 315
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1372,
          "y" : 315
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 134,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 72,
    "reactomeId" : 158961,
    "displayName" : "PLG(20-810):HRG",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 130,
      "y" : 315
    },
    "minX" : 86,
    "maxX" : 181,
    "minY" : 289,
    "maxY" : 336,
    "prop" : {
      "x" : 86,
      "y" : 295,
      "width" : 89,
      "height" : 41
    },
    "textPosition" : {
      "x" : 86,
      "y" : 301
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 175,
          "y" : 295
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 175,
          "y" : 295
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 75,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 51,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 60,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 137,
    "reactomeId" : 158774,
    "displayName" : "fibrin digestion products (plasmin)",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 567,
      "y" : 91
    },
    "minX" : 519,
    "maxX" : 616,
    "minY" : 67,
    "maxY" : 116,
    "prop" : {
      "x" : 519,
      "y" : 67,
      "width" : 97,
      "height" : 49
    },
    "textPosition" : {
      "x" : 532,
      "y" : 60
    },
    "connectors" : [ {
      "edgeId" : 80,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 76,
    "reactomeId" : 158926,
    "displayName" : "PLAU(21-431):PI-PLAUR",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 129,
      "y" : 173
    },
    "minX" : 76,
    "maxX" : 188,
    "minY" : 149,
    "maxY" : 248,
    "prop" : {
      "x" : 76,
      "y" : 155,
      "width" : 106,
      "height" : 36
    },
    "textPosition" : {
      "x" : 80,
      "y" : 156
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 182,
          "y" : 155
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 182,
          "y" : 155
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 70,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 73,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 60,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 129,
          "y" : 194
        },
        "to" : {
          "x" : 130,
          "y" : 240
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 130,
          "y" : 244
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 130,
          "y" : 244
        }
      }
    } ]
  }, {
    "id" : 77,
    "reactomeId" : 158797,
    "displayName" : "SERPINE1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 735,
      "y" : 590
    },
    "minX" : 131,
    "maxX" : 846,
    "minY" : 495,
    "maxY" : 659,
    "prop" : {
      "x" : 698,
      "y" : 579,
      "width" : 75,
      "height" : 22
    },
    "textPosition" : {
      "x" : 701,
      "y" : 579
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 773,
          "y" : 579
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 773,
          "y" : 579
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 64,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 695,
          "y" : 589
        },
        "to" : {
          "x" : 417,
          "y" : 589
        }
      }, {
        "from" : {
          "x" : 417,
          "y" : 589
        },
        "to" : {
          "x" : 240,
          "y" : 495
        }
      }, {
        "from" : {
          "x" : 240,
          "y" : 495
        },
        "to" : {
          "x" : 131,
          "y" : 495
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 74,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 753,
          "y" : 604
        },
        "to" : {
          "x" : 846,
          "y" : 657
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 63,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 720,
          "y" : 604
        },
        "to" : {
          "x" : 643,
          "y" : 659
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 78,
    "reactomeId" : 158997,
    "displayName" : "SERPINB2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 248,
      "y" : 642
    },
    "minX" : 130,
    "maxX" : 289,
    "minY" : 623,
    "maxY" : 655,
    "prop" : {
      "x" : 214,
      "y" : 629,
      "width" : 69,
      "height" : 26
    },
    "textPosition" : {
      "x" : 214,
      "y" : 631
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 283,
          "y" : 629
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 283,
          "y" : 629
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 56,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 211,
          "y" : 645
        },
        "to" : {
          "x" : 130,
          "y" : 654
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 79,
    "reactomeId" : 158764,
    "displayName" : "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 915,
      "y" : 187
    },
    "minX" : 846,
    "maxX" : 1241,
    "minY" : 149,
    "maxY" : 657,
    "prop" : {
      "x" : 851,
      "y" : 155,
      "width" : 129,
      "height" : 64
    },
    "textPosition" : {
      "x" : 853,
      "y" : 142
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 980,
          "y" : 155
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 980,
          "y" : 155
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 65,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 71,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 925,
          "y" : 222
        },
        "to" : {
          "x" : 950,
          "y" : 294
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 931,
          "y" : 227
        },
        "b" : {
          "x" : 925,
          "y" : 222
        },
        "c" : {
          "x" : 923,
          "y" : 230
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 923,
          "y" : 230
        }
      }
    }, {
      "edgeId" : 74,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 910,
          "y" : 222
        },
        "to" : {
          "x" : 846,
          "y" : 657
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 53,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 983,
          "y" : 186
        },
        "to" : {
          "x" : 1241,
          "y" : 186
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 88,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 81,
    "reactomeId" : 158699,
    "displayName" : "HRG",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1429,
      "y" : 52
    },
    "minX" : 1367,
    "maxX" : 1459,
    "minY" : 35,
    "maxY" : 106,
    "prop" : {
      "x" : 1406,
      "y" : 41,
      "width" : 47,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1412,
      "y" : 41
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1453,
          "y" : 41
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1453,
          "y" : 41
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1415,
          "y" : 66
        },
        "to" : {
          "x" : 1367,
          "y" : 103
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1412,
          "y" : 73
        },
        "b" : {
          "x" : 1415,
          "y" : 66
        },
        "c" : {
          "x" : 1407,
          "y" : 67
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1407,
          "y" : 67
        }
      }
    }, {
      "edgeId" : 89,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1423,
          "y" : 66
        },
        "to" : {
          "x" : 1400,
          "y" : 106
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 82,
    "reactomeId" : 158786,
    "displayName" : "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1191,
      "y" : 786
    },
    "minX" : 989,
    "maxX" : 1266,
    "minY" : 704,
    "maxY" : 825,
    "prop" : {
      "x" : 1123,
      "y" : 747,
      "width" : 137,
      "height" : 78
    },
    "textPosition" : {
      "x" : 1126,
      "y" : 748
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1260,
          "y" : 747
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1260,
          "y" : 747
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 87,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 90,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 90,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1125,
          "y" : 744
        },
        "to" : {
          "x" : 1058,
          "y" : 707
        }
      }, {
        "from" : {
          "x" : 1058,
          "y" : 707
        },
        "to" : {
          "x" : 997,
          "y" : 708
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 993,
          "y" : 708
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 993,
          "y" : 708
        }
      }
    } ]
  }, {
    "id" : 84,
    "reactomeId" : 158777,
    "displayName" : "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1125,
      "y" : 477
    },
    "minX" : 989,
    "maxX" : 1309,
    "minY" : 315,
    "maxY" : 516,
    "prop" : {
      "x" : 1058,
      "y" : 438,
      "width" : 134,
      "height" : 78
    },
    "textPosition" : {
      "x" : 1059,
      "y" : 439
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1192,
          "y" : 438
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1192,
          "y" : 438
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 130,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1123,
          "y" : 435
        },
        "to" : {
          "x" : 1120,
          "y" : 315
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 134,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1195,
          "y" : 452
        },
        "to" : {
          "x" : 1309,
          "y" : 409
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 71,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 71,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1096,
          "y" : 435
        },
        "to" : {
          "x" : 1049,
          "y" : 372
        }
      }, {
        "from" : {
          "x" : 1049,
          "y" : 372
        },
        "to" : {
          "x" : 997,
          "y" : 373
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 993,
          "y" : 373
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 993,
          "y" : 373
        }
      }
    }, {
      "edgeId" : 53,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 85,
    "reactomeId" : 159009,
    "displayName" : "PI-PLAUR:PLAU(21-177):PLAU(179-431):SERPINE1:SERPINB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 131,
      "y" : 770
    },
    "minX" : 61,
    "maxX" : 207,
    "minY" : 737,
    "maxY" : 797,
    "prop" : {
      "x" : 61,
      "y" : 743,
      "width" : 140,
      "height" : 54
    },
    "textPosition" : {
      "x" : 62,
      "y" : 748
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 201,
          "y" : 743
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 201,
          "y" : 743
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 56,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 86,
    "reactomeId" : 158701,
    "displayName" : "PLG(20-810)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1312,
      "y" : 54
    },
    "minX" : 307,
    "maxX" : 1431,
    "minY" : 0,
    "maxY" : 619,
    "prop" : {
      "x" : 1266,
      "y" : 40,
      "width" : 93,
      "height" : 28
    },
    "textPosition" : {
      "x" : 1270,
      "y" : 43
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1359,
          "y" : 40
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1359,
          "y" : 40
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 75,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1342,
          "y" : 37
        },
        "to" : {
          "x" : 1431,
          "y" : 0
        }
      }, {
        "from" : {
          "x" : 1431,
          "y" : 0
        },
        "to" : {
          "x" : 508,
          "y" : 0
        }
      }, {
        "from" : {
          "x" : 508,
          "y" : 0
        },
        "to" : {
          "x" : 307,
          "y" : 209
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 50,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1327,
          "y" : 71
        },
        "to" : {
          "x" : 1367,
          "y" : 103
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1335,
          "y" : 72
        },
        "b" : {
          "x" : 1327,
          "y" : 71
        },
        "c" : {
          "x" : 1330,
          "y" : 78
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1330,
          "y" : 78
        }
      }
    }, {
      "edgeId" : 53,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1304,
          "y" : 71
        },
        "to" : {
          "x" : 1241,
          "y" : 186
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 87,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1309,
          "y" : 71
        },
        "to" : {
          "x" : 1191,
          "y" : 619
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 89,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1335,
          "y" : 71
        },
        "to" : {
          "x" : 1400,
          "y" : 106
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 92,
    "reactomeId" : 2990857,
    "displayName" : "SERPINB2,6,8",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 51,
      "y" : 689
    },
    "minX" : 5,
    "maxX" : 122,
    "minY" : 675,
    "maxY" : 703,
    "prop" : {
      "x" : 5,
      "y" : 675,
      "width" : 92,
      "height" : 28
    },
    "textPosition" : {
      "x" : 5,
      "y" : 678
    },
    "connectors" : [ {
      "edgeId" : 56,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 103,
          "y" : 689
        },
        "to" : {
          "x" : 114,
          "y" : 689
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 118,
          "y" : 689
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 118,
          "y" : 689
        }
      }
    } ]
  }, {
    "id" : 93,
    "reactomeId" : 4127463,
    "displayName" : "SERPINE1-like proteins",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 743,
      "y" : 710
    },
    "minX" : 651,
    "maxX" : 838,
    "minY" : 692,
    "maxY" : 728,
    "prop" : {
      "x" : 698,
      "y" : 692,
      "width" : 90,
      "height" : 36
    },
    "textPosition" : {
      "x" : 700,
      "y" : 692
    },
    "connectors" : [ {
      "edgeId" : 74,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 794,
          "y" : 710
        },
        "to" : {
          "x" : 830,
          "y" : 711
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 834,
          "y" : 711
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 834,
          "y" : 711
        }
      }
    }, {
      "edgeId" : 63,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 692,
          "y" : 709
        },
        "to" : {
          "x" : 659,
          "y" : 708
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 655,
          "y" : 708
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 655,
          "y" : 708
        }
      }
    } ]
  }, {
    "id" : 95,
    "reactomeId" : 4127462,
    "displayName" : "SERPINE1-like proteins",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 56,
      "y" : 520
    },
    "minX" : 11,
    "maxX" : 123,
    "minY" : 502,
    "maxY" : 538,
    "prop" : {
      "x" : 11,
      "y" : 502,
      "width" : 90,
      "height" : 36
    },
    "textPosition" : {
      "x" : 13,
      "y" : 502
    },
    "connectors" : [ {
      "edgeId" : 64,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 107,
          "y" : 520
        },
        "to" : {
          "x" : 115,
          "y" : 520
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 119,
          "y" : 520
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 119,
          "y" : 520
        }
      }
    } ]
  }, {
    "id" : 96,
    "reactomeId" : 5336141,
    "displayName" : "ANXA2:S100A10 tetramer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1032,
      "y" : 325
    },
    "minX" : 975,
    "maxX" : 1095,
    "minY" : 301,
    "maxY" : 367,
    "prop" : {
      "x" : 975,
      "y" : 307,
      "width" : 114,
      "height" : 36
    },
    "textPosition" : {
      "x" : 976,
      "y" : 308
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1089,
          "y" : 307
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1089,
          "y" : 307
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 71,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1012,
          "y" : 346
        },
        "to" : {
          "x" : 988,
          "y" : 367
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 991,
          "y" : 359
        },
        "b" : {
          "x" : 988,
          "y" : 367
        },
        "c" : {
          "x" : 996,
          "y" : 365
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 996,
          "y" : 365
        }
      }
    } ]
  }, {
    "id" : 44,
    "reactomeId" : 158703,
    "displayName" : "histidine-rich glycoprotein:plasminogen",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1386,
      "y" : 203
    },
    "minX" : 1343,
    "maxX" : 1435,
    "minY" : 172,
    "maxY" : 228,
    "prop" : {
      "x" : 1343,
      "y" : 178,
      "width" : 86,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1343,
      "y" : 137
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1429,
          "y" : 178
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1429,
          "y" : 178
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 50,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 89,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 46,
    "reactomeId" : 158789,
    "displayName" : "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 643,
      "y" : 813
    },
    "minX" : 582,
    "maxX" : 710,
    "minY" : 761,
    "maxY" : 859,
    "prop" : {
      "x" : 582,
      "y" : 767,
      "width" : 122,
      "height" : 92
    },
    "textPosition" : {
      "x" : 581,
      "y" : 740
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 704,
          "y" : 767
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 704,
          "y" : 767
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 63,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 47,
    "reactomeId" : 158969,
    "displayName" : "PI-PLAUR:PLAU(21-177):PLAU(179-431)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 131,
      "y" : 441
    },
    "minX" : 5,
    "maxX" : 198,
    "minY" : 384,
    "maxY" : 654,
    "prop" : {
      "x" : 71,
      "y" : 416,
      "width" : 121,
      "height" : 50
    },
    "textPosition" : {
      "x" : 83,
      "y" : 417
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 192,
          "y" : 416
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 192,
          "y" : 416
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 64,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 131,
          "y" : 469
        },
        "to" : {
          "x" : 131,
          "y" : 495
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 73,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 51,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 130,
          "y" : 413
        },
        "to" : {
          "x" : 130,
          "y" : 392
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 130,
          "y" : 388
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 130,
          "y" : 388
        }
      }
    }, {
      "edgeId" : 56,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 74,
          "y" : 469
        },
        "to" : {
          "x" : 5,
          "y" : 497
        }
      }, {
        "from" : {
          "x" : 5,
          "y" : 497
        },
        "to" : {
          "x" : 5,
          "y" : 636
        }
      }, {
        "from" : {
          "x" : 5,
          "y" : 636
        },
        "to" : {
          "x" : 130,
          "y" : 654
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 48,
    "reactomeId" : 158417,
    "displayName" : "Zn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 286,
      "y" : 143
    },
    "minX" : 263,
    "maxX" : 310,
    "minY" : 127,
    "maxY" : 200,
    "prop" : {
      "x" : 263,
      "y" : 128,
      "width" : 46,
      "height" : 30
    },
    "textPosition" : {
      "x" : 264,
      "y" : 132
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 304,
          "y" : 133
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 304,
          "y" : 133
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 75,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 291,
          "y" : 161
        },
        "to" : {
          "x" : 305,
          "y" : 200
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 299,
          "y" : 195
        },
        "b" : {
          "x" : 305,
          "y" : 200
        },
        "c" : {
          "x" : 306,
          "y" : 192
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 306,
          "y" : 192
        }
      }
    } ]
  }, {
    "id" : 49,
    "reactomeId" : 158878,
    "displayName" : "alpha-2-antiplasmin:plasmin",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 529,
      "y" : 528
    },
    "minX" : 459,
    "maxX" : 605,
    "minY" : 504,
    "maxY" : 547,
    "prop" : {
      "x" : 459,
      "y" : 510,
      "width" : 140,
      "height" : 37
    },
    "textPosition" : {
      "x" : 461,
      "y" : 512
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 599,
          "y" : 510
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 599,
          "y" : 510
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 52,
    "reactomeId" : 141760,
    "displayName" : "SERPINF2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 451,
      "y" : 437
    },
    "minX" : 416,
    "maxX" : 529,
    "minY" : 399,
    "maxY" : 471,
    "prop" : {
      "x" : 416,
      "y" : 426,
      "width" : 70,
      "height" : 23
    },
    "textPosition" : {
      "x" : 417,
      "y" : 427
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 486,
          "y" : 426
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 486,
          "y" : 426
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 59,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 474,
          "y" : 423
        },
        "to" : {
          "x" : 529,
          "y" : 399
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 59,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 477,
          "y" : 452
        },
        "to" : {
          "x" : 514,
          "y" : 466
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 518,
          "y" : 467
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 518,
          "y" : 467
        }
      }
    } ]
  }, {
    "id" : 54,
    "reactomeId" : 158979,
    "displayName" : "PLAU(21-431)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 277,
      "y" : 62
    },
    "minX" : 127,
    "maxX" : 334,
    "minY" : 42,
    "maxY" : 88,
    "prop" : {
      "x" : 226,
      "y" : 48,
      "width" : 102,
      "height" : 28
    },
    "textPosition" : {
      "x" : 230,
      "y" : 51
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 328,
          "y" : 48
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 328,
          "y" : 48
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 70,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 223,
          "y" : 70
        },
        "to" : {
          "x" : 127,
          "y" : 88
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 55,
    "reactomeId" : 158946,
    "displayName" : "GPI-PLAUR",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 127,
      "y" : 37
    },
    "minX" : 92,
    "maxX" : 169,
    "minY" : 19,
    "maxY" : 88,
    "prop" : {
      "x" : 92,
      "y" : 25,
      "width" : 71,
      "height" : 24
    },
    "innerProp" : {
      "x" : 92,
      "y" : 31,
      "width" : 71,
      "height" : 18
    },
    "textPosition" : {
      "x" : 92,
      "y" : 26
    },
    "nodeAttachments" : [ {
      "reactomeId" : 9768813,
      "label" : "Am",
      "description" : "glycine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 305",
      "shape" : {
        "a" : {
          "x" : 104,
          "y" : 19
        },
        "b" : {
          "x" : 117,
          "y" : 32
        },
        "s" : "Am",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 110,
          "y" : 25
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 163,
          "y" : 25
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 163,
          "y" : 25
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 70,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 127,
          "y" : 52
        },
        "to" : {
          "x" : 127,
          "y" : 88
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 57,
    "reactomeId" : 158770,
    "displayName" : "Plasmin",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 631,
      "y" : 363
    },
    "minX" : 74,
    "maxX" : 981,
    "minY" : 194,
    "maxY" : 666,
    "prop" : {
      "x" : 605,
      "y" : 352,
      "width" : 52,
      "height" : 22
    },
    "textPosition" : {
      "x" : 607,
      "y" : 339
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 657,
          "y" : 352
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 657,
          "y" : 352
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 65,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 660,
          "y" : 363
        },
        "to" : {
          "x" : 906,
          "y" : 363
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 910,
          "y" : 363
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 910,
          "y" : 363
        }
      }
    }, {
      "edgeId" : 71,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 660,
          "y" : 357
        },
        "to" : {
          "x" : 950,
          "y" : 294
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 666,
          "y" : 352
        },
        "b" : {
          "x" : 660,
          "y" : 357
        },
        "c" : {
          "x" : 668,
          "y" : 359
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 668,
          "y" : 359
        }
      }
    }, {
      "edgeId" : 73,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 622,
          "y" : 349
        },
        "to" : {
          "x" : 522,
          "y" : 229
        }
      }, {
        "from" : {
          "x" : 522,
          "y" : 229
        },
        "to" : {
          "x" : 82,
          "y" : 234
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 78,
          "y" : 234
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 78,
          "y" : 234
        }
      }
    }, {
      "edgeId" : 80,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 626,
          "y" : 349
        },
        "to" : {
          "x" : 572,
          "y" : 202
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 570,
          "y" : 198
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 570,
          "y" : 198
        }
      }
    }, {
      "edgeId" : 51,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 602,
          "y" : 362
        },
        "to" : {
          "x" : 233,
          "y" : 361
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 595,
          "y" : 366
        },
        "b" : {
          "x" : 602,
          "y" : 362
        },
        "c" : {
          "x" : 595,
          "y" : 358
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 595,
          "y" : 358
        }
      }
    }, {
      "edgeId" : 90,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 643,
          "y" : 377
        },
        "to" : {
          "x" : 981,
          "y" : 666
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 651,
          "y" : 378
        },
        "b" : {
          "x" : 643,
          "y" : 377
        },
        "c" : {
          "x" : 646,
          "y" : 385
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 646,
          "y" : 385
        }
      }
    }, {
      "edgeId" : 59,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 602,
          "y" : 372
        },
        "to" : {
          "x" : 529,
          "y" : 399
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 60,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 611,
          "y" : 349
        },
        "to" : {
          "x" : 437,
          "y" : 254
        }
      }, {
        "from" : {
          "x" : 437,
          "y" : 254
        },
        "to" : {
          "x" : 261,
          "y" : 255
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 603,
          "y" : 349
        },
        "b" : {
          "x" : 611,
          "y" : 349
        },
        "c" : {
          "x" : 607,
          "y" : 342
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 607,
          "y" : 342
        }
      }
    } ]
  }, {
    "id" : 58,
    "reactomeId" : 159013,
    "displayName" : "PI-PLAUR:PLAU(21-177):PLAU(179-431):SERPINE1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 131,
      "y" : 593
    },
    "minX" : 68,
    "maxX" : 201,
    "minY" : 562,
    "maxY" : 618,
    "prop" : {
      "x" : 68,
      "y" : 568,
      "width" : 127,
      "height" : 50
    },
    "textPosition" : {
      "x" : 70,
      "y" : 569
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 195,
          "y" : 568
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 195,
          "y" : 568
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 64,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 61,
    "reactomeId" : 158927,
    "displayName" : "HRG",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 361,
      "y" : 299
    },
    "minX" : 233,
    "maxX" : 390,
    "minY" : 209,
    "maxY" : 361,
    "prop" : {
      "x" : 338,
      "y" : 286,
      "width" : 46,
      "height" : 27
    },
    "textPosition" : {
      "x" : 344,
      "y" : 289
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 384,
          "y" : 286
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 384,
          "y" : 286
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 75,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 352,
          "y" : 283
        },
        "to" : {
          "x" : 307,
          "y" : 209
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 51,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 335,
          "y" : 310
        },
        "to" : {
          "x" : 233,
          "y" : 361
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 331,
          "y" : 317
        },
        "b" : {
          "x" : 335,
          "y" : 310
        },
        "c" : {
          "x" : 327,
          "y" : 310
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 327,
          "y" : 310
        }
      }
    }, {
      "edgeId" : 60,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 335,
          "y" : 288
        },
        "to" : {
          "x" : 261,
          "y" : 255
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 327,
          "y" : 289
        },
        "b" : {
          "x" : 335,
          "y" : 288
        },
        "c" : {
          "x" : 330,
          "y" : 282
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 330,
          "y" : 282
        }
      }
    } ]
  }, {
    "id" : 62,
    "reactomeId" : 158754,
    "displayName" : "PLAT(36-562)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 729,
      "y" : 120
    },
    "minX" : 676,
    "maxX" : 789,
    "minY" : 103,
    "maxY" : 189,
    "prop" : {
      "x" : 676,
      "y" : 109,
      "width" : 106,
      "height" : 22
    },
    "textPosition" : {
      "x" : 683,
      "y" : 109
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 782,
          "y" : 109
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 782,
          "y" : 109
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 88,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 738,
          "y" : 134
        },
        "to" : {
          "x" : 789,
          "y" : 189
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 64,
    "reactomeId" : 159005,
    "displayName" : "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 131,
      "y" : 520
    },
    "minX" : 125,
    "maxX" : 137,
    "minY" : 495,
    "maxY" : 565,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 131,
        "y" : 495
      },
      "to" : {
        "x" : 131,
        "y" : 520
      }
    }, {
      "from" : {
        "x" : 131,
        "y" : 520
      },
      "to" : {
        "x" : 131,
        "y" : 565
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 127,
        "y" : 558
      },
      "b" : {
        "x" : 131,
        "y" : 565
      },
      "c" : {
        "x" : 135,
        "y" : 558
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 135,
        "y" : 558
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 125,
        "y" : 514
      },
      "b" : {
        "x" : 137,
        "y" : 526
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 131,
        "y" : 520
      }
    },
    "inputs" : [ {
      "id" : 47,
      "points" : [ {
        "x" : 131,
        "y" : 469
      } ]
    }, {
      "id" : 77,
      "points" : [ {
        "x" : 695,
        "y" : 589
      }, {
        "x" : 417,
        "y" : 589
      }, {
        "x" : 240,
        "y" : 495
      } ]
    } ],
    "outputs" : [ {
      "id" : 58
    } ],
    "catalysts" : [ {
      "id" : 95,
      "points" : [ {
        "x" : 107,
        "y" : 520
      } ]
    } ]
  }, {
    "id" : 65,
    "reactomeId" : 158747,
    "displayName" : "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 922,
      "y" : 363
    },
    "minX" : 916,
    "maxX" : 971,
    "minY" : 222,
    "maxY" : 525,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 916,
        "y" : 222
      },
      "to" : {
        "x" : 922,
        "y" : 363
      }
    }, {
      "from" : {
        "x" : 922,
        "y" : 363
      },
      "to" : {
        "x" : 971,
        "y" : 525
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 965,
        "y" : 520
      },
      "b" : {
        "x" : 971,
        "y" : 525
      },
      "c" : {
        "x" : 973,
        "y" : 517
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 973,
        "y" : 517
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 916,
        "y" : 357
      },
      "b" : {
        "x" : 928,
        "y" : 369
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 922,
        "y" : 363
      }
    },
    "inputs" : [ {
      "id" : 79
    } ],
    "outputs" : [ {
      "id" : 66
    } ],
    "catalysts" : [ {
      "id" : 57,
      "points" : [ {
        "x" : 660,
        "y" : 363
      } ]
    } ]
  }, {
    "id" : 130,
    "reactomeId" : 9724753,
    "displayName" : "PLG(20-810) binds anti-fibrinolytics",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1120,
      "y" : 314
    },
    "minX" : 1076,
    "maxX" : 1125,
    "minY" : 284,
    "maxY" : 319,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1120,
        "y" : 315
      },
      "to" : {
        "x" : 1120,
        "y" : 314
      }
    }, {
      "from" : {
        "x" : 1120,
        "y" : 314
      },
      "to" : {
        "x" : 1076,
        "y" : 284
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1084,
        "y" : 285
      },
      "b" : {
        "x" : 1076,
        "y" : 284
      },
      "c" : {
        "x" : 1079,
        "y" : 291
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1079,
        "y" : 291
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1120,
        "y" : 314
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1120,
        "y" : 314
      }
    },
    "inputs" : [ {
      "id" : 84,
      "points" : [ {
        "x" : 1123,
        "y" : 435
      } ]
    }, {
      "id" : 131,
      "points" : [ {
        "x" : 1156,
        "y" : 246
      } ]
    } ],
    "outputs" : [ {
      "id" : 132
    } ]
  }, {
    "id" : 70,
    "reactomeId" : 158959,
    "displayName" : "urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 128,
      "y" : 89
    },
    "minX" : 123,
    "maxX" : 133,
    "minY" : 84,
    "maxY" : 152,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 127,
        "y" : 88
      },
      "to" : {
        "x" : 128,
        "y" : 89
      }
    }, {
      "from" : {
        "x" : 128,
        "y" : 89
      },
      "to" : {
        "x" : 128,
        "y" : 152
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 124,
        "y" : 145
      },
      "b" : {
        "x" : 128,
        "y" : 152
      },
      "c" : {
        "x" : 132,
        "y" : 145
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 132,
        "y" : 145
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 128,
        "y" : 89
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 128,
        "y" : 89
      }
    },
    "inputs" : [ {
      "id" : 54,
      "points" : [ {
        "x" : 223,
        "y" : 70
      } ]
    }, {
      "id" : 55,
      "points" : [ {
        "x" : 127,
        "y" : 52
      } ]
    } ],
    "outputs" : [ {
      "id" : 76
    } ]
  }, {
    "id" : 134,
    "reactomeId" : 9724745,
    "displayName" : "PLG(20-810) binds aprotinin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1315,
      "y" : 381
    },
    "minX" : 1304,
    "maxX" : 1321,
    "minY" : 353,
    "maxY" : 414,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1309,
        "y" : 409
      },
      "to" : {
        "x" : 1315,
        "y" : 381
      }
    }, {
      "from" : {
        "x" : 1315,
        "y" : 381
      },
      "to" : {
        "x" : 1321,
        "y" : 353
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1323,
        "y" : 361
      },
      "b" : {
        "x" : 1321,
        "y" : 353
      },
      "c" : {
        "x" : 1316,
        "y" : 359
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1316,
        "y" : 359
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1315,
        "y" : 381
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1315,
        "y" : 381
      }
    },
    "inputs" : [ {
      "id" : 135,
      "points" : [ {
        "x" : 1365,
        "y" : 457
      } ]
    }, {
      "id" : 84,
      "points" : [ {
        "x" : 1195,
        "y" : 452
      } ]
    } ],
    "outputs" : [ {
      "id" : 136
    } ]
  }, {
    "id" : 71,
    "reactomeId" : 158750,
    "displayName" : "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 981,
      "y" : 373
    },
    "minX" : 950,
    "maxX" : 1055,
    "minY" : 294,
    "maxY" : 465,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1055,
        "y" : 465
      },
      "to" : {
        "x" : 981,
        "y" : 453
      }
    }, {
      "from" : {
        "x" : 981,
        "y" : 453
      },
      "to" : {
        "x" : 981,
        "y" : 373
      }
    }, {
      "from" : {
        "x" : 981,
        "y" : 373
      },
      "to" : {
        "x" : 950,
        "y" : 294
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 975,
        "y" : 367
      },
      "b" : {
        "x" : 987,
        "y" : 379
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 981,
        "y" : 373
      }
    },
    "inputs" : [ {
      "id" : 84
    } ],
    "outputs" : [ {
      "id" : 57,
      "points" : [ {
        "x" : 660,
        "y" : 357
      } ]
    }, {
      "id" : 79,
      "points" : [ {
        "x" : 925,
        "y" : 222
      } ]
    } ],
    "catalysts" : [ {
      "id" : 84,
      "points" : [ {
        "x" : 1096,
        "y" : 435
      }, {
        "x" : 1049,
        "y" : 372
      } ]
    } ],
    "activators" : [ {
      "id" : 96,
      "points" : [ {
        "x" : 1012,
        "y" : 346
      } ]
    } ]
  }, {
    "id" : 73,
    "reactomeId" : 158942,
    "displayName" : "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 66,
      "y" : 234
    },
    "minX" : 60,
    "maxX" : 110,
    "minY" : 194,
    "maxY" : 413,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 110,
        "y" : 194
      },
      "to" : {
        "x" : 66,
        "y" : 234
      }
    }, {
      "from" : {
        "x" : 66,
        "y" : 234
      },
      "to" : {
        "x" : 66,
        "y" : 385
      }
    }, {
      "from" : {
        "x" : 66,
        "y" : 385
      },
      "to" : {
        "x" : 101,
        "y" : 413
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 93,
        "y" : 412
      },
      "b" : {
        "x" : 101,
        "y" : 413
      },
      "c" : {
        "x" : 98,
        "y" : 406
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 98,
        "y" : 406
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 60,
        "y" : 228
      },
      "b" : {
        "x" : 72,
        "y" : 240
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 66,
        "y" : 234
      }
    },
    "inputs" : [ {
      "id" : 76
    } ],
    "outputs" : [ {
      "id" : 47
    } ],
    "catalysts" : [ {
      "id" : 57,
      "points" : [ {
        "x" : 622,
        "y" : 349
      }, {
        "x" : 522,
        "y" : 229
      } ]
    } ]
  }, {
    "id" : 74,
    "reactomeId" : 158795,
    "displayName" : "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 846,
      "y" : 711
    },
    "minX" : 840,
    "maxX" : 852,
    "minY" : 657,
    "maxY" : 765,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 846,
        "y" : 657
      },
      "to" : {
        "x" : 846,
        "y" : 711
      }
    }, {
      "from" : {
        "x" : 846,
        "y" : 711
      },
      "to" : {
        "x" : 846,
        "y" : 765
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 842,
        "y" : 758
      },
      "b" : {
        "x" : 846,
        "y" : 765
      },
      "c" : {
        "x" : 850,
        "y" : 758
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 850,
        "y" : 758
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 840,
        "y" : 705
      },
      "b" : {
        "x" : 852,
        "y" : 717
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 846,
        "y" : 711
      }
    },
    "inputs" : [ {
      "id" : 77,
      "points" : [ {
        "x" : 753,
        "y" : 604
      } ]
    }, {
      "id" : 79,
      "points" : [ {
        "x" : 910,
        "y" : 222
      } ]
    } ],
    "outputs" : [ {
      "id" : 68
    } ],
    "catalysts" : [ {
      "id" : 93,
      "points" : [ {
        "x" : 794,
        "y" : 710
      } ]
    } ]
  }, {
    "id" : 75,
    "reactomeId" : 158941,
    "displayName" : "plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 308,
      "y" : 208
    },
    "minX" : 164,
    "maxX" : 313,
    "minY" : 203,
    "maxY" : 292,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 307,
        "y" : 209
      },
      "to" : {
        "x" : 308,
        "y" : 208
      }
    }, {
      "from" : {
        "x" : 308,
        "y" : 208
      },
      "to" : {
        "x" : 164,
        "y" : 292
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 168,
        "y" : 285
      },
      "b" : {
        "x" : 164,
        "y" : 292
      },
      "c" : {
        "x" : 172,
        "y" : 292
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 172,
        "y" : 292
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 308,
        "y" : 208
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 308,
        "y" : 208
      }
    },
    "inputs" : [ {
      "id" : 86,
      "points" : [ {
        "x" : 1342,
        "y" : 37
      }, {
        "x" : 1431,
        "y" : 0
      }, {
        "x" : 508,
        "y" : 0
      } ]
    }, {
      "id" : 61,
      "points" : [ {
        "x" : 352,
        "y" : 283
      } ]
    } ],
    "outputs" : [ {
      "id" : 72
    } ],
    "activators" : [ {
      "id" : 48,
      "points" : [ {
        "x" : 291,
        "y" : 161
      } ]
    } ]
  }, {
    "id" : 80,
    "reactomeId" : 158766,
    "displayName" : "fibrin multimer, crosslinked -> fibrin digestion products (plasmin)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 566,
      "y" : 187
    },
    "minX" : 560,
    "maxX" : 621,
    "minY" : 119,
    "maxY" : 193,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 621,
        "y" : 188
      },
      "to" : {
        "x" : 566,
        "y" : 187
      }
    }, {
      "from" : {
        "x" : 566,
        "y" : 187
      },
      "to" : {
        "x" : 566,
        "y" : 119
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 570,
        "y" : 126
      },
      "b" : {
        "x" : 566,
        "y" : 119
      },
      "c" : {
        "x" : 562,
        "y" : 126
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 562,
        "y" : 126
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 560,
        "y" : 181
      },
      "b" : {
        "x" : 572,
        "y" : 193
      },
      "s" : "",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 566,
        "y" : 187
      }
    },
    "inputs" : [ {
      "id" : 67
    } ],
    "outputs" : [ {
      "id" : 137
    } ],
    "catalysts" : [ {
      "id" : 57,
      "points" : [ {
        "x" : 626,
        "y" : 349
      } ]
    } ]
  }, {
    "id" : 50,
    "reactomeId" : 158721,
    "displayName" : "histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1357,
      "y" : 137
    },
    "minX" : 1351,
    "maxX" : 1375,
    "minY" : 103,
    "maxY" : 175,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 1375,
        "y" : 175
      },
      "to" : {
        "x" : 1357,
        "y" : 137
      }
    }, {
      "from" : {
        "x" : 1357,
        "y" : 137
      },
      "to" : {
        "x" : 1367,
        "y" : 103
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1357,
        "y" : 137
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 1357,
        "y" : 137
      }
    },
    "inputs" : [ {
      "id" : 44
    } ],
    "outputs" : [ {
      "id" : 81,
      "points" : [ {
        "x" : 1415,
        "y" : 66
      } ]
    }, {
      "id" : 86,
      "points" : [ {
        "x" : 1327,
        "y" : 71
      } ]
    } ]
  }, {
    "id" : 51,
    "reactomeId" : 158925,
    "displayName" : "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 130,
      "y" : 376
    },
    "minX" : 124,
    "maxX" : 233,
    "minY" : 339,
    "maxY" : 382,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 130,
        "y" : 339
      },
      "to" : {
        "x" : 130,
        "y" : 376
      }
    }, {
      "from" : {
        "x" : 130,
        "y" : 376
      },
      "to" : {
        "x" : 183,
        "y" : 376
      }
    }, {
      "from" : {
        "x" : 183,
        "y" : 376
      },
      "to" : {
        "x" : 233,
        "y" : 361
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 124,
        "y" : 370
      },
      "b" : {
        "x" : 136,
        "y" : 382
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 130,
        "y" : 376
      }
    },
    "inputs" : [ {
      "id" : 72
    } ],
    "outputs" : [ {
      "id" : 57,
      "points" : [ {
        "x" : 602,
        "y" : 362
      } ]
    }, {
      "id" : 61,
      "points" : [ {
        "x" : 335,
        "y" : 310
      } ]
    } ],
    "catalysts" : [ {
      "id" : 47,
      "points" : [ {
        "x" : 130,
        "y" : 413
      } ]
    } ]
  }, {
    "id" : 53,
    "reactomeId" : 158784,
    "displayName" : "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1242,
      "y" : 186
    },
    "minX" : 1140,
    "maxX" : 1247,
    "minY" : 181,
    "maxY" : 435,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1241,
        "y" : 186
      },
      "to" : {
        "x" : 1242,
        "y" : 186
      }
    }, {
      "from" : {
        "x" : 1242,
        "y" : 186
      },
      "to" : {
        "x" : 1140,
        "y" : 435
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1139,
        "y" : 427
      },
      "b" : {
        "x" : 1140,
        "y" : 435
      },
      "c" : {
        "x" : 1146,
        "y" : 430
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1146,
        "y" : 430
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1242,
        "y" : 186
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1242,
        "y" : 186
      }
    },
    "inputs" : [ {
      "id" : 86,
      "points" : [ {
        "x" : 1304,
        "y" : 71
      } ]
    }, {
      "id" : 79,
      "points" : [ {
        "x" : 983,
        "y" : 186
      } ]
    } ],
    "outputs" : [ {
      "id" : 84
    } ]
  }, {
    "id" : 87,
    "reactomeId" : 158756,
    "displayName" : "crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1190,
      "y" : 690
    },
    "minX" : 1184,
    "maxX" : 1196,
    "minY" : 619,
    "maxY" : 744,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1191,
        "y" : 619
      },
      "to" : {
        "x" : 1190,
        "y" : 690
      }
    }, {
      "from" : {
        "x" : 1190,
        "y" : 690
      },
      "to" : {
        "x" : 1190,
        "y" : 744
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1186,
        "y" : 737
      },
      "b" : {
        "x" : 1190,
        "y" : 744
      },
      "c" : {
        "x" : 1194,
        "y" : 737
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1194,
        "y" : 737
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1190,
        "y" : 690
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1190,
        "y" : 690
      }
    },
    "inputs" : [ {
      "id" : 66,
      "points" : [ {
        "x" : 1049,
        "y" : 578
      } ]
    }, {
      "id" : 86,
      "points" : [ {
        "x" : 1309,
        "y" : 71
      } ]
    } ],
    "outputs" : [ {
      "id" : 82
    } ]
  }, {
    "id" : 56,
    "reactomeId" : 159001,
    "displayName" : "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 130,
      "y" : 689
    },
    "minX" : 124,
    "maxX" : 136,
    "minY" : 654,
    "maxY" : 740,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 130,
        "y" : 654
      },
      "to" : {
        "x" : 130,
        "y" : 689
      }
    }, {
      "from" : {
        "x" : 130,
        "y" : 689
      },
      "to" : {
        "x" : 130,
        "y" : 740
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 126,
        "y" : 733
      },
      "b" : {
        "x" : 130,
        "y" : 740
      },
      "c" : {
        "x" : 134,
        "y" : 733
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 134,
        "y" : 733
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 124,
        "y" : 683
      },
      "b" : {
        "x" : 136,
        "y" : 695
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 130,
        "y" : 689
      }
    },
    "inputs" : [ {
      "id" : 47,
      "points" : [ {
        "x" : 74,
        "y" : 469
      }, {
        "x" : 5,
        "y" : 497
      }, {
        "x" : 5,
        "y" : 636
      } ]
    }, {
      "id" : 78,
      "points" : [ {
        "x" : 211,
        "y" : 645
      } ]
    } ],
    "outputs" : [ {
      "id" : 85
    } ],
    "catalysts" : [ {
      "id" : 92,
      "points" : [ {
        "x" : 103,
        "y" : 689
      } ]
    } ]
  }, {
    "id" : 88,
    "reactomeId" : 158781,
    "displayName" : "crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 787,
      "y" : 187
    },
    "minX" : 782,
    "maxX" : 848,
    "minY" : 182,
    "maxY" : 192,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 789,
        "y" : 189
      },
      "to" : {
        "x" : 787,
        "y" : 187
      }
    }, {
      "from" : {
        "x" : 787,
        "y" : 187
      },
      "to" : {
        "x" : 848,
        "y" : 187
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 841,
        "y" : 191
      },
      "b" : {
        "x" : 848,
        "y" : 187
      },
      "c" : {
        "x" : 841,
        "y" : 183
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 841,
        "y" : 183
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 787,
        "y" : 187
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 787,
        "y" : 187
      }
    },
    "inputs" : [ {
      "id" : 67,
      "points" : [ {
        "x" : 726,
        "y" : 189
      } ]
    }, {
      "id" : 62,
      "points" : [ {
        "x" : 738,
        "y" : 134
      } ]
    } ],
    "outputs" : [ {
      "id" : 79
    } ]
  }, {
    "id" : 89,
    "reactomeId" : 158722,
    "displayName" : "histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1409,
      "y" : 136
    },
    "minX" : 1394,
    "maxX" : 1415,
    "minY" : 106,
    "maxY" : 175,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1400,
        "y" : 106
      },
      "to" : {
        "x" : 1409,
        "y" : 136
      }
    }, {
      "from" : {
        "x" : 1409,
        "y" : 136
      },
      "to" : {
        "x" : 1394,
        "y" : 175
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1393,
        "y" : 167
      },
      "b" : {
        "x" : 1394,
        "y" : 175
      },
      "c" : {
        "x" : 1400,
        "y" : 170
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1400,
        "y" : 170
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1409,
        "y" : 136
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1409,
        "y" : 136
      }
    },
    "inputs" : [ {
      "id" : 81,
      "points" : [ {
        "x" : 1423,
        "y" : 66
      } ]
    }, {
      "id" : 86,
      "points" : [ {
        "x" : 1335,
        "y" : 71
      } ]
    } ],
    "outputs" : [ {
      "id" : 44
    } ]
  }, {
    "id" : 90,
    "reactomeId" : 158744,
    "displayName" : "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 981,
      "y" : 708
    },
    "minX" : 975,
    "maxX" : 1120,
    "minY" : 666,
    "maxY" : 780,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1120,
        "y" : 780
      },
      "to" : {
        "x" : 981,
        "y" : 768
      }
    }, {
      "from" : {
        "x" : 981,
        "y" : 768
      },
      "to" : {
        "x" : 981,
        "y" : 708
      }
    }, {
      "from" : {
        "x" : 981,
        "y" : 708
      },
      "to" : {
        "x" : 981,
        "y" : 666
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 975,
        "y" : 702
      },
      "b" : {
        "x" : 987,
        "y" : 714
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 981,
        "y" : 708
      }
    },
    "inputs" : [ {
      "id" : 82
    } ],
    "outputs" : [ {
      "id" : 57,
      "points" : [ {
        "x" : 643,
        "y" : 377
      } ]
    }, {
      "id" : 66,
      "points" : [ {
        "x" : 981,
        "y" : 595
      } ]
    } ],
    "catalysts" : [ {
      "id" : 82,
      "points" : [ {
        "x" : 1125,
        "y" : 744
      }, {
        "x" : 1058,
        "y" : 707
      } ]
    } ]
  }, {
    "id" : 59,
    "reactomeId" : 158893,
    "displayName" : "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 529,
      "y" : 471
    },
    "minX" : 523,
    "maxX" : 535,
    "minY" : 399,
    "maxY" : 507,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 529,
        "y" : 399
      },
      "to" : {
        "x" : 529,
        "y" : 471
      }
    }, {
      "from" : {
        "x" : 529,
        "y" : 471
      },
      "to" : {
        "x" : 529,
        "y" : 507
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 525,
        "y" : 500
      },
      "b" : {
        "x" : 529,
        "y" : 507
      },
      "c" : {
        "x" : 533,
        "y" : 500
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 533,
        "y" : 500
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 523,
        "y" : 465
      },
      "b" : {
        "x" : 535,
        "y" : 477
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 529,
        "y" : 471
      }
    },
    "inputs" : [ {
      "id" : 57,
      "points" : [ {
        "x" : 602,
        "y" : 372
      } ]
    }, {
      "id" : 52,
      "points" : [ {
        "x" : 474,
        "y" : 423
      } ]
    } ],
    "outputs" : [ {
      "id" : 49
    } ],
    "catalysts" : [ {
      "id" : 52,
      "points" : [ {
        "x" : 477,
        "y" : 452
      } ]
    } ]
  }, {
    "id" : 60,
    "reactomeId" : 158982,
    "displayName" : "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 130,
      "y" : 256
    },
    "minX" : 124,
    "maxX" : 261,
    "minY" : 250,
    "maxY" : 292,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 130,
        "y" : 292
      },
      "to" : {
        "x" : 130,
        "y" : 256
      }
    }, {
      "from" : {
        "x" : 130,
        "y" : 256
      },
      "to" : {
        "x" : 261,
        "y" : 255
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 124,
        "y" : 250
      },
      "b" : {
        "x" : 136,
        "y" : 262
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 130,
        "y" : 256
      }
    },
    "inputs" : [ {
      "id" : 72
    } ],
    "outputs" : [ {
      "id" : 57,
      "points" : [ {
        "x" : 611,
        "y" : 349
      }, {
        "x" : 437,
        "y" : 254
      } ]
    }, {
      "id" : 61,
      "points" : [ {
        "x" : 335,
        "y" : 288
      } ]
    } ],
    "catalysts" : [ {
      "id" : 76,
      "points" : [ {
        "x" : 129,
        "y" : 194
      } ]
    } ]
  }, {
    "id" : 63,
    "reactomeId" : 158800,
    "displayName" : "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 643,
      "y" : 708
    },
    "minX" : 637,
    "maxX" : 649,
    "minY" : 659,
    "maxY" : 764,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 643,
        "y" : 659
      },
      "to" : {
        "x" : 643,
        "y" : 708
      }
    }, {
      "from" : {
        "x" : 643,
        "y" : 708
      },
      "to" : {
        "x" : 643,
        "y" : 764
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 639,
        "y" : 757
      },
      "b" : {
        "x" : 643,
        "y" : 764
      },
      "c" : {
        "x" : 647,
        "y" : 757
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 647,
        "y" : 757
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 637,
        "y" : 702
      },
      "b" : {
        "x" : 649,
        "y" : 714
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 643,
        "y" : 708
      }
    },
    "inputs" : [ {
      "id" : 66,
      "points" : [ {
        "x" : 914,
        "y" : 578
      } ]
    }, {
      "id" : 77,
      "points" : [ {
        "x" : 720,
        "y" : 604
      } ]
    } ],
    "outputs" : [ {
      "id" : 46
    } ],
    "catalysts" : [ {
      "id" : 93,
      "points" : [ {
        "x" : 692,
        "y" : 709
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 91,
    "reactomeId" : 876,
    "displayName" : "plasma membrane",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 103,
      "y" : 408
    },
    "minX" : 0,
    "maxX" : 206,
    "minY" : 13,
    "maxY" : 803,
    "prop" : {
      "x" : 0,
      "y" : 13,
      "width" : 206,
      "height" : 790
    },
    "textPosition" : {
      "x" : 3,
      "y" : 104
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 55, 76, 47, 72, 73, 58, 64, 56, 85, 70, 60, 51, 92, 95 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1459,
  "minY" : 0,
  "maxY" : 860,
  "disease" : false
}