{ "dbId" : 6807070, "stId" : "R-HSA-6807070", "speciesName" : "Homo sapiens", "nodes" : [ { "dbId" : 389121, "stId" : "R-HSA-389121", "displayName" : "BMI1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P35226", "standardIdentifier" : "uniprot:P35226", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "BMI1", "PCGF4", "RNF51" ], "parents" : [ 3229073 ], "children" : [ ] }, { "dbId" : 389122, "stId" : "R-HSA-389122", "displayName" : "SCMH1-2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q96GD3-2", "standardIdentifier" : "uniprot:Q96GD3-2", "referenceType" : "ReferenceIsoform", "geneNames" : [ "SCMH1" ], "parents" : [ 3229073 ], "children" : [ ] }, { "dbId" : 2980903, "stId" : "R-HSA-2980903", "displayName" : "SNAI1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O95863", "standardIdentifier" : "uniprot:O95863", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SNAI1", "SNAH" ], "parents" : [ 8944073 ], "children" : [ ] }, { "dbId" : 2980898, "stId" : "R-HSA-2980898", "displayName" : "SNAI2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O43623", "standardIdentifier" : "uniprot:O43623", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SNAI2", "SLUG", "SLUGH" ], "parents" : [ 8944073 ], "children" : [ ] }, { "dbId" : 1031706, "stId" : "R-HSA-1031706", "displayName" : "PML [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 61 ], "identifier" : "P29590", "standardIdentifier" : "uniprot:P29590", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PML", "MYL", "PP8675", "RNF71", "TRIM19" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 5653582, "stId" : "R-HSA-5653582", "displayName" : "LAMTOR1 [lysosomal membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q6IAA8", "standardIdentifier" : "uniprot:Q6IAA8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LAMTOR1", "C11orf59", "PDRO", "PP7157" ], "parents" : [ 5653921 ], "children" : [ ] }, { "dbId" : 1031703, "stId" : "R-HSA-1031703", "displayName" : "EGR1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 10 ], "identifier" : "P18146", "standardIdentifier" : "uniprot:P18146", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "EGR1", "KROX24", "ZNF225" ], "parents" : [ 8944084 ], "children" : [ ] }, { "dbId" : 5653583, "stId" : "R-HSA-5653583", "displayName" : "LAMTOR2 [lysosomal membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9Y2Q5", "standardIdentifier" : "uniprot:Q9Y2Q5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LAMTOR2", "MAPBPIP", "ROBLD3", "HSPC003" ], "parents" : [ 5653921 ], "children" : [ ] }, { "dbId" : 5653581, "stId" : "R-HSA-5653581", "displayName" : "LAMTOR3 [lysosomal membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9UHA4", "standardIdentifier" : "uniprot:Q9UHA4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LAMTOR3", "MAP2K1IP1", "MAPKSP1", "PRO2783" ], "parents" : [ 5653921 ], "children" : [ ] }, { "dbId" : 5653579, "stId" : "R-HSA-5653579", "displayName" : "RRAGB [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q5VZM2", "standardIdentifier" : "uniprot:Q5VZM2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RRAGB" ], "parents" : [ 5653976 ], "children" : [ ] }, { "dbId" : 5653577, "stId" : "R-HSA-5653577", "displayName" : "RRAGA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q7L523", "standardIdentifier" : "uniprot:Q7L523", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RRAGA" ], "parents" : [ 5653978 ], "children" : [ ] }, { "dbId" : 452644, "stId" : "R-HSA-452644", "displayName" : "SALL4 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 19 ], "identifier" : "Q9UJQ4", "standardIdentifier" : "uniprot:Q9UJQ4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SALL4", "ZNF797" ], "parents" : [ 8943729, 8943778 ], "children" : [ ] }, { "dbId" : 8943778, "stId" : "R-HSA-8943778", "displayName" : "SALL4:NuRD [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8943781 ], "children" : [ 4657018, 452644 ] }, { "dbId" : 8943781, "stId" : "R-HSA-8943781", "displayName" : "SALL4:NuRD:PTEN gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 23 ], "parents" : [ ], "children" : [ 8943778, 5632949 ] }, { "dbId" : 1268261, "stId" : "R-HSA-1268261", "displayName" : "p-T,Y MAPK dimers [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 40 ], "parents" : [ ], "children" : [ 109855, 109844 ] }, { "dbId" : 377400, "stId" : "R-HSA-377400", "displayName" : "mTORC1 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5653972 ], "children" : [ 165676, 165662, 3006727 ] }, { "dbId" : 2026077, "stId" : "R-HSA-2026077", "displayName" : "PPARG:Fatty Acid Ligand [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 138 ], "parents" : [ 8944097 ], "children" : [ 446172, 381235 ] }, { "dbId" : 6807075, "stId" : "R-HSA-6807075", "displayName" : "NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 15 ], "parents" : [ 6807085 ], "children" : [ 6808474, 376207 ] }, { "dbId" : 8943820, "stId" : "R-HSA-8943820", "displayName" : "MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8943821 ], "children" : [ 8943822, 8943897 ] }, { "dbId" : 8943821, "stId" : "R-HSA-8943821", "displayName" : "MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 29 ], "parents" : [ ], "children" : [ 8943820, 5632949 ] }, { "dbId" : 8943822, "stId" : "R-HSA-8943822", "displayName" : "PRC1.4,PRC2 (EZH2) core [nucleoplasm]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 28 ], "parents" : [ 8943820 ], "children" : [ 212285, 3229073 ] }, { "dbId" : 8943810, "stId" : "R-HSA-8943810", "displayName" : "MECOM:PTEN gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 26 ], "parents" : [ ], "children" : [ 8943897, 5632949 ] }, { "dbId" : 6807085, "stId" : "R-HSA-6807085", "displayName" : "NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7):PTEN Gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 16 ], "parents" : [ ], "children" : [ 6807075, 5632949 ] }, { "dbId" : 6807083, "stId" : "R-HSA-6807083", "displayName" : "ATN1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P54259", "standardIdentifier" : "uniprot:P54259", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATN1", "D12S755E", "DRPLA" ], "parents" : [ 6808474 ], "children" : [ ] }, { "dbId" : 9907911, "stId" : "R-HSA-9907911", "displayName" : "20S CP outer ring [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9907918 ], "children" : [ 68734, 68732, 68730, 68728, 68726, 68724, 68736 ] }, { "dbId" : 9907905, "stId" : "R-HSA-9907905", "displayName" : "20S CP inner ring [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9907918 ], "children" : [ 68750, 68747, 68744, 68759, 68756, 68738, 68753 ] }, { "dbId" : 3004533, "stId" : "R-HSA-3004533", "displayName" : "HDAC5 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9UQL6", "standardIdentifier" : "uniprot:Q9UQL6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HDAC5", "KIAA0600" ], "parents" : [ 6808476 ], "children" : [ ] }, { "dbId" : 9907918, "stId" : "R-HSA-9907918", "displayName" : "20S core particle [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 68819 ], "children" : [ 9907905, 9907911 ] }, { "dbId" : 3004534, "stId" : "R-HSA-3004534", "displayName" : "HDAC7 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q8WUI4", "standardIdentifier" : "uniprot:Q8WUI4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HDAC7", "HDAC7A" ], "parents" : [ 6808476 ], "children" : [ ] }, { "dbId" : 442464, "stId" : "R-HSA-442464", "displayName" : "HDAC3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O15379", "standardIdentifier" : "uniprot:O15379", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HDAC3" ], "parents" : [ 6808476 ], "children" : [ ] }, { "dbId" : 975970, "stId" : "R-HSA-975970", "displayName" : "STUB1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9UNE7", "standardIdentifier" : "uniprot:Q9UNE7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "STUB1", "CHIP", "PP1131" ], "parents" : [ 6807286 ], "children" : [ ] }, { "dbId" : 68722, "stId" : "R-HSA-68722", "displayName" : "PSMD14 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O00487", "standardIdentifier" : "uniprot:O00487", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD14", "POH1" ], "parents" : [ 9907994 ], "children" : [ ] }, { "dbId" : 68724, "stId" : "R-HSA-68724", "displayName" : "PSMA1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P25786", "standardIdentifier" : "uniprot:P25786", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA1", "HC2", "NU", "PROS30", "PSC2" ], "parents" : [ 9907911 ], "children" : [ ] }, { "dbId" : 975992, "stId" : "R-HSA-975992", "displayName" : "NEDD4 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P46934", "standardIdentifier" : "uniprot:P46934", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NEDD4", "KIAA0093", "NEDD4-1", "RPF1", "PIG53" ], "parents" : [ 6807286, 6807260 ], "children" : [ ] }, { "dbId" : 68726, "stId" : "R-HSA-68726", "displayName" : "PSMA2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P25787", "standardIdentifier" : "uniprot:P25787", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA2", "HC3", "PSC3" ], "parents" : [ 9907911 ], "children" : [ ] }, { "dbId" : 9907950, "stId" : "R-HSA-9907950", "displayName" : "PSMC3:PSMC6 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9908170 ], "children" : [ 68783, 68774 ] }, { "dbId" : 68728, "stId" : "R-HSA-68728", "displayName" : "PSMA3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P25788", "standardIdentifier" : "uniprot:P25788", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA3", "HC8", "PSC8" ], "parents" : [ 9907911 ], "children" : [ ] }, { "dbId" : 9907949, "stId" : "R-HSA-9907949", "displayName" : "PSMC4:PSMC5 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9908170 ], "children" : [ 68780, 68777 ] }, { "dbId" : 68730, "stId" : "R-HSA-68730", "displayName" : "PSMA4 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P25789", "standardIdentifier" : "uniprot:P25789", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA4", "HC9", "PSC9" ], "parents" : [ 9907911 ], "children" : [ ] }, { "dbId" : 9907947, "stId" : "R-HSA-9907947", "displayName" : "PSMC2:PSMC1 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9908171 ], "children" : [ 68771, 68768 ] }, { "dbId" : 68732, "stId" : "R-HSA-68732", "displayName" : "PSMA5 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P28066", "standardIdentifier" : "uniprot:P28066", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA5" ], "parents" : [ 9907911 ], "children" : [ ] }, { "dbId" : 68734, "stId" : "R-HSA-68734", "displayName" : "PSMA6 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P60900", "standardIdentifier" : "uniprot:P60900", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA6", "PROS27" ], "parents" : [ 9907911 ], "children" : [ ] }, { "dbId" : 68736, "stId" : "R-HSA-68736", "displayName" : "PSMA7 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O14818", "standardIdentifier" : "uniprot:O14818", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMA7", "HSPC" ], "parents" : [ 9907911 ], "children" : [ ] }, { "dbId" : 8850949, "stId" : "R-HSA-8850949", "displayName" : "PREX2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 95 ], "identifier" : "Q70Z35", "standardIdentifier" : "uniprot:Q70Z35", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PREX2", "DEPDC2" ], "parents" : [ 8850934 ], "children" : [ ] }, { "dbId" : 68738, "stId" : "R-HSA-68738", "displayName" : "PSMB1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P20618", "standardIdentifier" : "uniprot:P20618", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB1", "PSC5" ], "parents" : [ 9907905 ], "children" : [ ] }, { "dbId" : 6807264, "stId" : "R-HSA-6807264", "displayName" : "MonoUb-K13,K289-PTEN [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 55 ], "identifier" : "P60484", "standardIdentifier" : "uniprot:P60484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PTEN", "MMAC1", "TEP1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 6807279, "stId" : "R-HSA-6807279", "displayName" : "WWP2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O00308", "standardIdentifier" : "uniprot:O00308", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "WWP2" ], "parents" : [ 6807286 ], "children" : [ ] }, { "dbId" : 68744, "stId" : "R-HSA-68744", "displayName" : "PSMB2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P49721", "standardIdentifier" : "uniprot:P49721", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB2" ], "parents" : [ 9907905 ], "children" : [ ] }, { "dbId" : 68747, "stId" : "R-HSA-68747", "displayName" : "PSMB3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P49720", "standardIdentifier" : "uniprot:P49720", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB3" ], "parents" : [ 9907905 ], "children" : [ ] }, { "dbId" : 8944643, "stId" : "R-HSA-8944643", "displayName" : "miR-214 Nonendonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1677 ], "parents" : [ 8944647 ], "children" : [ 8944644, 427772, 427775 ] }, { "dbId" : 8944644, "stId" : "R-HSA-8944644", "displayName" : "miR-214 Nonendonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944643 ], "children" : [ 8944638, 210613 ] }, { "dbId" : 5215938, "stId" : "R-HSA-5215938", "displayName" : "SLC38A9 [lysosomal membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q8NBW4", "standardIdentifier" : "uniprot:Q8NBW4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SLC38A9", "URLC11" ], "parents" : [ 8952725 ], "children" : [ ] }, { "dbId" : 8938501, "stId" : "R-HSA-8938501", "displayName" : "miR-106a [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000113", "standardIdentifier" : "mirbase:MI0000113", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR106A" ], "parents" : [ 8945703 ], "children" : [ ] }, { "dbId" : 6807273, "stId" : "R-HSA-6807273", "displayName" : "PTEN [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 58 ], "identifier" : "P60484", "standardIdentifier" : "uniprot:P60484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PTEN", "MMAC1", "TEP1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 68750, "stId" : "R-HSA-68750", "displayName" : "PSMB4 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P28070", "standardIdentifier" : "uniprot:P28070", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB4", "PROS26" ], "parents" : [ 9907905 ], "children" : [ ] }, { "dbId" : 8944647, "stId" : "R-HSA-8944647", "displayName" : "miR-214 Nonendonucleolytic RISC:PTEN mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1574 ], "parents" : [ ], "children" : [ 8944643, 2318746 ] }, { "dbId" : 68753, "stId" : "R-HSA-68753", "displayName" : "PSMB5 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P28074", "standardIdentifier" : "uniprot:P28074", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB5", "LMPX", "MB1", "X" ], "parents" : [ 9907905 ], "children" : [ ] }, { "dbId" : 8944664, "stId" : "R-HSA-8944664", "displayName" : "miR-205 Nonendonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944674 ], "children" : [ 427772, 427775, 8944666 ] }, { "dbId" : 6807286, "stId" : "R-HSA-6807286", "displayName" : "NEDD4,STUB1,WWP2 and XIAP [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 68 ], "parents" : [ ], "children" : [ 975970, 6807279, 975992, 50849 ] }, { "dbId" : 8944665, "stId" : "R-HSA-8944665", "displayName" : "miR-205 Endonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944674 ], "children" : [ 427772, 427775, 8944668 ] }, { "dbId" : 939164, "stId" : "R-HSA-939164", "displayName" : "UBC(77-152) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 8944666, "stId" : "R-HSA-8944666", "displayName" : "miR-205 Nonendonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944664 ], "children" : [ 8944661, 210613 ] }, { "dbId" : 939165, "stId" : "R-HSA-939165", "displayName" : "UBC(609-684) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 8944668, "stId" : "R-HSA-8944668", "displayName" : "miR-205 Endonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944665 ], "children" : [ 8944661, 209723 ] }, { "dbId" : 8945692, "stId" : "R-HSA-8945692", "displayName" : "miR-19b1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000074", "standardIdentifier" : "mirbase:MI0000074", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR19B1" ], "parents" : [ 8945717 ], "children" : [ ] }, { "dbId" : 68756, "stId" : "R-HSA-68756", "displayName" : "PSMB6 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P28072", "standardIdentifier" : "uniprot:P28072", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB6", "LMPY", "Y" ], "parents" : [ 9907905 ], "children" : [ ] }, { "dbId" : 68759, "stId" : "R-HSA-68759", "displayName" : "PSMB7 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q99436", "standardIdentifier" : "uniprot:Q99436", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMB7", "Z" ], "parents" : [ 9907905 ], "children" : [ ] }, { "dbId" : 1257604, "stId" : "R-HSA-1257604", "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "speciesId" : 48887, "diagramIds" : [ 1113 ] }, { "dbId" : 6807280, "stId" : "R-HSA-6807280", "displayName" : "PolyUb-PTEN [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 67 ], "identifier" : "P60484", "standardIdentifier" : "uniprot:P60484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PTEN", "MMAC1", "TEP1" ], "parents" : [ 8948842, 8948784 ], "children" : [ ] }, { "dbId" : 8944661, "stId" : "R-HSA-8944661", "displayName" : "miR-205 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000285", "standardIdentifier" : "mirbase:MI0000285", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR205" ], "parents" : [ 8944668, 8944666 ], "children" : [ ] }, { "dbId" : 197277, "stId" : "R-ALL-197277", "displayName" : "NAM [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 1856 ], "identifier" : "17154", "standardIdentifier" : "chebi:17154", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 8948758, "stId" : "R-HSA-8948758", "displayName" : "p-S109-MKRN1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1682 ], "identifier" : "Q9UHC7", "standardIdentifier" : "uniprot:Q9UHC7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MKRN1", "RNF61" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8945704, "stId" : "R-HSA-8945704", "displayName" : "miR-20 Nonendonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8945696 ], "children" : [ 8945701, 427772, 427775 ] }, { "dbId" : 8948777, "stId" : "R-HSA-8948777", "displayName" : "K48polyUb-K289-PTEN [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1743 ], "identifier" : "P60484", "standardIdentifier" : "uniprot:P60484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PTEN", "MMAC1", "TEP1" ], "parents" : [ 8948842, 8948784 ], "children" : [ ] }, { "dbId" : 68768, "stId" : "R-HSA-68768", "displayName" : "PSMC1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62191", "standardIdentifier" : "uniprot:P62191", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMC1" ], "parents" : [ 9907947 ], "children" : [ ] }, { "dbId" : 50849, "stId" : "R-HSA-50849", "displayName" : "XIAP [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P98170", "standardIdentifier" : "uniprot:P98170", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "XIAP", "API3", "BIRC4", "IAP3" ], "parents" : [ 6807286, 6807260 ], "children" : [ ] }, { "dbId" : 8945705, "stId" : "R-HSA-8945705", "displayName" : "miR-20b [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0001519", "standardIdentifier" : "mirbase:MI0001519", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR20B" ], "parents" : [ 8945697 ], "children" : [ ] }, { "dbId" : 68771, "stId" : "R-HSA-68771", "displayName" : "PSMC2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P35998", "standardIdentifier" : "uniprot:P35998", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMC2", "MSS1" ], "parents" : [ 9907947 ], "children" : [ ] }, { "dbId" : 8945707, "stId" : "R-HSA-8945707", "displayName" : "miR-20 RISC:PTEN mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1578 ], "parents" : [ ], "children" : [ 2318746, 8945696 ] }, { "dbId" : 976042, "stId" : "R-HSA-976042", "displayName" : "MKRN1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1680 ], "identifier" : "Q9UHC7", "standardIdentifier" : "uniprot:Q9UHC7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MKRN1", "RNF61" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8945708, "stId" : "R-HSA-8945708", "displayName" : "CNOT6L mRNA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1590 ], "identifier" : "ENST00000264903", "standardIdentifier" : "ensembl:ENST00000264903", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "CNOT6L" ], "parents" : [ 8948580, 8948622, 8948605, 8948610, 8948650 ], "children" : [ ] }, { "dbId" : 8945710, "stId" : "R-HSA-8945710", "displayName" : "miR-20 Endonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8945713 ], "children" : [ 8945697, 209723 ] }, { "dbId" : 68774, "stId" : "R-HSA-68774", "displayName" : "PSMC3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P17980", "standardIdentifier" : "uniprot:P17980", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMC3", "TBP1" ], "parents" : [ 9907950 ], "children" : [ ] }, { "dbId" : 68777, "stId" : "R-HSA-68777", "displayName" : "PSMC4 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P43686", "standardIdentifier" : "uniprot:P43686", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMC4", "MIP224", "TBP7" ], "parents" : [ 9907949 ], "children" : [ ] }, { "dbId" : 6807247, "stId" : "R-HSA-6807247", "displayName" : "MonoUb-K13,K289-PTEN [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 52 ], "identifier" : "P60484", "standardIdentifier" : "uniprot:P60484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PTEN", "MMAC1", "TEP1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8945696, "stId" : "R-HSA-8945696", "displayName" : "miR-20 RISC [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 1635 ], "parents" : [ 8948537, 8948624, 8948622, 8945707 ], "children" : [ 8945713, 8945704 ] }, { "dbId" : 8945697, "stId" : "R-HSA-8945697", "displayName" : "miR-20 [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "parents" : [ 8945710, 8945701 ], "children" : [ 8938481, 8945705 ] }, { "dbId" : 8944674, "stId" : "R-HSA-8944674", "displayName" : "miR-205 RISC [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 1674 ], "parents" : [ 8944679 ], "children" : [ 8944665, 8944664 ] }, { "dbId" : 8945698, "stId" : "R-HSA-8945698", "displayName" : "PTENP1 mRNA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1595 ], "identifier" : "ENST00000532280", "standardIdentifier" : "ensembl:ENST00000532280", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "PTENP1" ], "parents" : [ 8948537, 8948521 ], "children" : [ ] }, { "dbId" : 8945699, "stId" : "R-HSA-8945699", "displayName" : "miR-19b2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000075", "standardIdentifier" : "mirbase:MI0000075", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR19B2" ], "parents" : [ 8945717 ], "children" : [ ] }, { "dbId" : 29356, "stId" : "R-ALL-29356", "displayName" : "H2O [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 1781 ], "identifier" : "15377", "standardIdentifier" : "chebi:15377", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 68780, "stId" : "R-HSA-68780", "displayName" : "PSMC5 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62195", "standardIdentifier" : "uniprot:P62195", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMC5", "SUG1" ], "parents" : [ 9907949 ], "children" : [ ] }, { "dbId" : 8945701, "stId" : "R-HSA-8945701", "displayName" : "miR-20 Nonendonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8945704 ], "children" : [ 8945697, 210613 ] }, { "dbId" : 68783, "stId" : "R-HSA-68783", "displayName" : "PSMC6 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62333", "standardIdentifier" : "uniprot:P62333", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMC6", "SUG2" ], "parents" : [ 9907950 ], "children" : [ ] }, { "dbId" : 8944679, "stId" : "R-HSA-8944679", "displayName" : "miR-205 RISC:PTEN mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1577 ], "parents" : [ ], "children" : [ 8944674, 2318746 ] }, { "dbId" : 8945703, "stId" : "R-HSA-8945703", "displayName" : "miR-106 [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "parents" : [ 8944621, 8944618 ], "children" : [ 8944614, 8938501 ] }, { "dbId" : 29360, "stId" : "R-ALL-29360", "displayName" : "NAD+ [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 1854 ], "identifier" : "57540", "standardIdentifier" : "chebi:57540", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 68786, "stId" : "R-HSA-68786", "displayName" : "PSMD1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q99460", "standardIdentifier" : "uniprot:Q99460", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD1" ], "parents" : [ 9908170 ], "children" : [ ] }, { "dbId" : 210615, "stId" : "R-HSA-210615", "displayName" : "EIF2C3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9H9G7", "standardIdentifier" : "uniprot:Q9H9G7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AGO3", "EIF2C3" ], "parents" : [ 210613 ], "children" : [ ] }, { "dbId" : 8944700, "stId" : "R-HSA-8944700", "displayName" : "miR-21 Nonendonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944705 ], "children" : [ 5432789, 210613 ] }, { "dbId" : 939192, "stId" : "R-HSA-939192", "displayName" : "UBC(229-304) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 8948798, "stId" : "R-HSA-8948798", "displayName" : "RibC-E40,E150,D326-PTEN [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1855 ], "identifier" : "P60484", "standardIdentifier" : "uniprot:P60484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PTEN", "MMAC1", "TEP1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 210613, "stId" : "R-HSA-210613", "displayName" : "Nonendonucleolytic Argonaute [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 2318739, 8948549, 8944644, 8944539, 8945701, 8938454, 8944597, 8944700, 8944666, 8944618, 8944507, 8944568 ], "children" : [ 210615, 210612, 210616 ] }, { "dbId" : 68790, "stId" : "R-HSA-68790", "displayName" : "PSMD11 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O00231", "standardIdentifier" : "uniprot:O00231", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD11" ], "parents" : [ 9907993 ], "children" : [ ] }, { "dbId" : 210612, "stId" : "R-HSA-210612", "displayName" : "EIF2C4 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9HCK5", "standardIdentifier" : "uniprot:Q9HCK5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AGO4", "EIF2C4", "KIAA1567" ], "parents" : [ 210613 ], "children" : [ ] }, { "dbId" : 8944703, "stId" : "R-HSA-8944703", "displayName" : "miR-21 Nonendonucleolytic RISC:PTEN mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1579 ], "parents" : [ ], "children" : [ 2318746, 8944705 ] }, { "dbId" : 8948784, "stId" : "R-HSA-8948784", "displayName" : "PolyUb-PTEN,K48polyUb-K289-PTEN [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 1773 ], "parents" : [ ], "children" : [ 6807280, 8948777 ] }, { "dbId" : 8945712, "stId" : "R-HSA-8945712", "displayName" : "VAPA mRNA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1587 ], "identifier" : "ENST00000340541", "standardIdentifier" : "ensembl:ENST00000340541", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "VAPA" ], "parents" : [ 8948581, 8948624, 8948593, 8948642 ], "children" : [ ] }, { "dbId" : 939191, "stId" : "R-HSA-939191", "displayName" : "UBC(381-456) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 68792, "stId" : "R-HSA-68792", "displayName" : "PSMD12 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O00232", "standardIdentifier" : "uniprot:O00232", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD12" ], "parents" : [ 9907994 ], "children" : [ ] }, { "dbId" : 8945713, "stId" : "R-HSA-8945713", "displayName" : "miR-20 Endonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8945696 ], "children" : [ 427772, 427775, 8945710 ] }, { "dbId" : 939188, "stId" : "R-HSA-939188", "displayName" : "UBC(1-76) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 29370, "stId" : "R-ALL-29370", "displayName" : "ADP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 1681, 373, 2021, 89 ], "identifier" : "456216", "standardIdentifier" : "chebi:456216", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 68794, "stId" : "R-HSA-68794", "displayName" : "PSMD13 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9UNM6", "standardIdentifier" : "uniprot:Q9UNM6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD13" ], "parents" : [ 9907994 ], "children" : [ ] }, { "dbId" : 6807260, "stId" : "R-HSA-6807260", "displayName" : "XIAP,NEDD4 [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 53 ], "parents" : [ ], "children" : [ 975992, 50849 ] }, { "dbId" : 210616, "stId" : "R-HSA-210616", "displayName" : "EIF2C1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9UL18", "standardIdentifier" : "uniprot:Q9UL18", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AGO1", "EIF2C1" ], "parents" : [ 210613 ], "children" : [ ] }, { "dbId" : 8851002, "stId" : "R-HSA-8851002", "displayName" : "TRIM27 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 101 ], "identifier" : "P14373", "standardIdentifier" : "uniprot:P14373", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TRIM27", "RFP", "RNF76" ], "parents" : [ 8851000 ], "children" : [ ] }, { "dbId" : 68796, "stId" : "R-HSA-68796", "displayName" : "PSMD2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q13200", "standardIdentifier" : "uniprot:Q13200", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD2", "TRAP2" ], "parents" : [ 9908171 ], "children" : [ ] }, { "dbId" : 8945717, "stId" : "R-HSA-8945717", "displayName" : "miR-19b [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 8944514, 8944507 ], "children" : [ 8945699, 8945692 ] }, { "dbId" : 939184, "stId" : "R-HSA-939184", "displayName" : "UBC(457-532) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 8851000, "stId" : "R-HSA-8851000", "displayName" : "PTEN:TRIM27 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 102 ], "parents" : [ ], "children" : [ 199420, 8851002 ] }, { "dbId" : 68798, "stId" : "R-HSA-68798", "displayName" : "PSMD3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O43242", "standardIdentifier" : "uniprot:O43242", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD3" ], "parents" : [ 9908004 ], "children" : [ ] }, { "dbId" : 939214, "stId" : "R-HSA-939214", "displayName" : "UBB(1-76) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 939213, "stId" : "R-HSA-939213", "displayName" : "UBB(77-152) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 68804, "stId" : "R-HSA-68804", "displayName" : "PSMD6 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q15008", "standardIdentifier" : "uniprot:Q15008", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD6", "KIAA0107", "PFAAP4" ], "parents" : [ 9908004 ], "children" : [ ] }, { "dbId" : 5665939, "stId" : "R-HSA-5665939", "displayName" : "ADRM1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q16186", "standardIdentifier" : "uniprot:Q16186", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ADRM1", "GP110" ], "parents" : [ 9908170 ], "children" : [ ] }, { "dbId" : 450243, "stId" : "R-HSA-450243", "displayName" : "p-T69,T71-ATF2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 263 ], "identifier" : "P15336", "standardIdentifier" : "uniprot:P15336", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ATF2", "CREB2", "CREBP1" ], "parents" : [ 8944392 ], "children" : [ ] }, { "dbId" : 8851009, "stId" : "R-HSA-8851009", "displayName" : "K27polyUb-PTEN [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 104 ], "identifier" : "P60484", "standardIdentifier" : "uniprot:P60484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PTEN", "MMAC1", "TEP1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 68806, "stId" : "R-HSA-68806", "displayName" : "PSMD7 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P51665", "standardIdentifier" : "uniprot:P51665", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD7", "MOV34L" ], "parents" : [ 9907994 ], "children" : [ ] }, { "dbId" : 68808, "stId" : "R-HSA-68808", "displayName" : "PSMD8 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P48556", "standardIdentifier" : "uniprot:P48556", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PSMD8" ], "parents" : [ 9908021 ], "children" : [ ] }, { "dbId" : 8944705, "stId" : "R-HSA-8944705", "displayName" : "miR-21 Nonendonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1652 ], "parents" : [ 8944703 ], "children" : [ 427772, 427775, 8944700 ] }, { "dbId" : 939205, "stId" : "R-HSA-939205", "displayName" : "RPS27A(1-76) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62979", "standardIdentifier" : "uniprot:P62979", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RPS27A", "UBA80", "UBCEP1" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 450250, "stId" : "R-HSA-450250", "displayName" : "JUN [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 38 ], "identifier" : "P05412", "standardIdentifier" : "uniprot:P05412", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "JUN" ], "parents" : [ 8944060 ], "children" : [ ] }, { "dbId" : 939203, "stId" : "R-HSA-939203", "displayName" : "UBA52(1-76) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62987", "standardIdentifier" : "uniprot:P62987", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBA52", "UBCEP2" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 939230, "stId" : "R-HSA-939230", "displayName" : "UBB(153-228) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 68819, "stId" : "R-HSA-68819", "displayName" : "26S proteasome [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 71 ], "parents" : [ ], "children" : [ 9907918, 9908177 ] }, { "dbId" : 198356, "stId" : "R-HSA-198356", "displayName" : "p-T308,S473-AKT1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P31749", "standardIdentifier" : "uniprot:P31749", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AKT1", "PKB", "RAC" ], "parents" : [ 202074 ], "children" : [ ] }, { "dbId" : 8847965, "stId" : "R-HSA-8847965", "displayName" : "p-Y387-FRK [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 80 ], "identifier" : "P42685", "standardIdentifier" : "uniprot:P42685", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "FRK", "PTK5", "RAK" ], "parents" : [ 8847960 ], "children" : [ ] }, { "dbId" : 446172, "stId" : "R-HSA-446172", "displayName" : "PPARG [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P37231", "standardIdentifier" : "uniprot:P37231", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PPARG", "NR1C3" ], "parents" : [ 2026077 ], "children" : [ ] }, { "dbId" : 205021, "stId" : "R-HSA-205021", "displayName" : "HDAC1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q13547", "standardIdentifier" : "uniprot:Q13547", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HDAC1", "RPD3L1" ], "parents" : [ 4657004 ], "children" : [ ] }, { "dbId" : 8847960, "stId" : "R-HSA-8847960", "displayName" : "PTEN:p-Y387-FRK [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 81 ], "parents" : [ ], "children" : [ 199420, 8847965 ] }, { "dbId" : 8948841, "stId" : "R-HSA-8948841", "displayName" : "PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1990 ], "identifier" : "P60484", "standardIdentifier" : "uniprot:P60484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PTEN", "MMAC1", "TEP1" ], "parents" : [ 8948842 ], "children" : [ ] }, { "dbId" : 8948842, "stId" : "R-HSA-8948842", "displayName" : "PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 2011 ], "parents" : [ ], "children" : [ 6807280, 8948841, 8948777 ] }, { "dbId" : 9007201, "stId" : "R-HSA-9007201", "displayName" : "RING1,RNF2 [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 3229073 ], "children" : [ 389113, 389119 ] }, { "dbId" : 939239, "stId" : "R-HSA-939239", "displayName" : "UBC(533-608) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 9007200, "stId" : "R-HSA-9007200", "displayName" : "PHC1,PHC2,PHC3 [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 3229073 ], "children" : [ 389112, 389116, 389111 ] }, { "dbId" : 9007203, "stId" : "R-HSA-9007203", "displayName" : "CBX2,CBX4,CBX6,CBX8 [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 3229073 ], "children" : [ 3229071, 389118, 389117, 389110 ] }, { "dbId" : 8847980, "stId" : "R-HSA-8847980", "displayName" : "p-Y336-PTEN [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 2020 ], "identifier" : "P60484", "standardIdentifier" : "uniprot:P60484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PTEN", "MMAC1", "TEP1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 29420, "stId" : "R-ALL-29420", "displayName" : "GDP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "58189", "standardIdentifier" : "chebi:58189", "referenceType" : "ReferenceMolecule", "parents" : [ 5653973, 5653970 ], "children" : [ ] }, { "dbId" : 939232, "stId" : "R-HSA-939232", "displayName" : "UBC(305-380) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 939258, "stId" : "R-HSA-939258", "displayName" : "UBC(153-228) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 113595 ], "children" : [ ] }, { "dbId" : 8948849, "stId" : "R-HSA-8948849", "displayName" : "USP13,OTUD3 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 2040 ], "parents" : [ ], "children" : [ 8873955, 6781893 ] }, { "dbId" : 8943729, "stId" : "R-HSA-8943729", "displayName" : "SALL4:PTEN gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 20 ], "parents" : [ ], "children" : [ 452644, 5632949 ] }, { "dbId" : 427775, "stId" : "R-HSA-427775", "displayName" : "TNRC6 (GW182) [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 2318738, 2318744, 8948548, 8948550, 8944643, 8944540, 8944541, 8945704, 8945713, 8938444, 8944488, 8944598, 8944592, 8944705, 8944664, 8944665, 8944620, 8944622, 8944508, 8944512, 8944566, 8944571 ], "children" : [ 427776, 427777, 427769 ] }, { "dbId" : 212217, "stId" : "R-HSA-212217", "displayName" : "SUZ12 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q15022", "standardIdentifier" : "uniprot:Q15022", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SUZ12", "CHET9", "JJAZ1", "KIAA0160" ], "parents" : [ 212285 ], "children" : [ ] }, { "dbId" : 427772, "stId" : "R-HSA-427772", "displayName" : "MOV10 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9HCE1", "standardIdentifier" : "uniprot:Q9HCE1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MOV10", "KIAA1631" ], "parents" : [ 2318738, 2318744, 8948548, 8948550, 8944643, 8944540, 8944541, 8945704, 8945713, 8938444, 8944488, 8944598, 8944592, 8944705, 8944664, 8944665, 8944620, 8944622, 8944508, 8944512, 8944566, 8944571 ], "children" : [ ] }, { "dbId" : 212223, "stId" : "R-HSA-212223", "displayName" : "RBBP4 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q09028", "standardIdentifier" : "uniprot:Q09028", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RBBP4", "RBAP48" ], "parents" : [ 4839773, 4657018 ], "children" : [ ] }, { "dbId" : 480506, "stId" : "R-HSA-480506", "displayName" : "REST [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q13127", "standardIdentifier" : "uniprot:Q13127", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "REST", "NRSF", "XBR" ], "parents" : [ 4657015 ], "children" : [ ] }, { "dbId" : 29438, "stId" : "R-ALL-29438", "displayName" : "GTP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "37565", "standardIdentifier" : "chebi:37565", "referenceType" : "ReferenceMolecule", "parents" : [ 165189, 5653978, 5653976 ], "children" : [ ] }, { "dbId" : 199420, "stId" : "R-HSA-199420", "displayName" : "PTEN [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 49 ], "identifier" : "P60484", "standardIdentifier" : "uniprot:P60484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PTEN", "MMAC1", "TEP1" ], "parents" : [ 8850937, 8847960, 8851000 ], "children" : [ ] }, { "dbId" : 427769, "stId" : "R-HSA-427769", "displayName" : "TNRC6A [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q8NDV7", "standardIdentifier" : "uniprot:Q8NDV7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TNRC6A", "CAGH26", "KIAA1460", "TNRC6" ], "parents" : [ 427775 ], "children" : [ ] }, { "dbId" : 212227, "stId" : "R-HSA-212227", "displayName" : "RBBP7 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q16576", "standardIdentifier" : "uniprot:Q16576", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RBBP7", "RBAP46" ], "parents" : [ 4839773, 4657018 ], "children" : [ ] }, { "dbId" : 8944524, "stId" : "R-HSA-8944524", "displayName" : "miR-19a RISC:PTEN mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1571 ], "parents" : [ ], "children" : [ 2318746, 8948559 ] }, { "dbId" : 3702077, "stId" : "R-HSA-3702077", "displayName" : "GATAD2A [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q86YP4", "standardIdentifier" : "uniprot:Q86YP4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "GATAD2A" ], "parents" : [ 4657014 ], "children" : [ ] }, { "dbId" : 3702078, "stId" : "R-HSA-3702078", "displayName" : "CHD4 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q14839", "standardIdentifier" : "uniprot:Q14839", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CHD4" ], "parents" : [ 4657021 ], "children" : [ ] }, { "dbId" : 427776, "stId" : "R-HSA-427776", "displayName" : "TNRC6C [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9HCJ0", "standardIdentifier" : "uniprot:Q9HCJ0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TNRC6C", "KIAA1582" ], "parents" : [ 427775 ], "children" : [ ] }, { "dbId" : 8948622, "stId" : "R-HSA-8948622", "displayName" : "miR-20 RISC:CNOT6L mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1638 ], "parents" : [ ], "children" : [ 8945696, 8945708 ] }, { "dbId" : 3702079, "stId" : "R-HSA-3702079", "displayName" : "GATAD2B [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q8WXI9", "standardIdentifier" : "uniprot:Q8WXI9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "GATAD2B", "KIAA1150" ], "parents" : [ 4657014 ], "children" : [ ] }, { "dbId" : 427777, "stId" : "R-HSA-427777", "displayName" : "TNRC6B [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9UPQ9", "standardIdentifier" : "uniprot:Q9UPQ9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TNRC6B", "KIAA1093" ], "parents" : [ 427775 ], "children" : [ ] }, { "dbId" : 8944512, "stId" : "R-HSA-8944512", "displayName" : "miR-19b Endonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8948558 ], "children" : [ 8944514, 427772, 427775 ] }, { "dbId" : 8944514, "stId" : "R-HSA-8944514", "displayName" : "miR-19b Endonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944512 ], "children" : [ 8945717, 209723 ] }, { "dbId" : 8948610, "stId" : "R-HSA-8948610", "displayName" : "miR-19b RISC:CNOT6L mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1611 ], "parents" : [ ], "children" : [ 8948558, 8945708 ] }, { "dbId" : 8944024, "stId" : "R-HSA-8944024", "displayName" : "SNAI1,SNAI2:PTEN gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 35 ], "parents" : [ ], "children" : [ 8944073, 5632949 ] }, { "dbId" : 8944536, "stId" : "R-HSA-8944536", "displayName" : "miR-22 Endonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944541 ], "children" : [ 8944533, 209723 ] }, { "dbId" : 109842, "stId" : "R-HSA-109842", "displayName" : "p-T202,Y204-MAPK3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P27361", "standardIdentifier" : "uniprot:P27361", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MAPK3", "ERK1", "PRKM3" ], "parents" : [ 109844 ], "children" : [ ] }, { "dbId" : 8944539, "stId" : "R-HSA-8944539", "displayName" : "miR-22 Nonendonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944540 ], "children" : [ 8944533, 210613 ] }, { "dbId" : 4839773, "stId" : "R-HSA-4839773", "displayName" : "RBBP4,7 [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 212285 ], "children" : [ 212223, 212227 ] }, { "dbId" : 8944540, "stId" : "R-HSA-8944540", "displayName" : "miR-22 Nonendonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944549 ], "children" : [ 427772, 427775, 8944539 ] }, { "dbId" : 109844, "stId" : "R-HSA-109844", "displayName" : "p-T202, Y204 MAPK3 dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 1268261 ], "children" : [ 109842 ] }, { "dbId" : 8944541, "stId" : "R-HSA-8944541", "displayName" : "miR-22 Endonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944549 ], "children" : [ 427772, 427775, 8944536 ] }, { "dbId" : 8948624, "stId" : "R-HSA-8948624", "displayName" : "miR-20 RISC:VAPA mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1636 ], "parents" : [ ], "children" : [ 8945712, 8945696 ] }, { "dbId" : 165662, "stId" : "R-HSA-165662", "displayName" : "MTOR [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P42345", "standardIdentifier" : "uniprot:P42345", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MTOR", "FRAP", "FRAP1", "FRAP2", "RAFT1", "RAPT1" ], "parents" : [ 377400 ], "children" : [ ] }, { "dbId" : 109853, "stId" : "R-HSA-109853", "displayName" : "p-T185,Y187-MAPK1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P28482", "standardIdentifier" : "uniprot:P28482", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MAPK1", "ERK2", "PRKM1", "PRKM2" ], "parents" : [ 109855 ], "children" : [ ] }, { "dbId" : 8952725, "stId" : "R-HSA-8952725", "displayName" : "Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5653972 ], "children" : [ 5653979, 5215938 ] }, { "dbId" : 8944533, "stId" : "R-HSA-8944533", "displayName" : "miR-22 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000078", "standardIdentifier" : "mirbase:MI0000078", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR22" ], "parents" : [ 8944536, 8944539 ], "children" : [ ] }, { "dbId" : 109855, "stId" : "R-HSA-109855", "displayName" : "p-T185,Y187 MAPK1 dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 1268261 ], "children" : [ 109853 ] }, { "dbId" : 8948650, "stId" : "R-HSA-8948650", "displayName" : "miR-106 RISC:CNOT6L mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1643 ], "parents" : [ ], "children" : [ 8944629, 8945708 ] }, { "dbId" : 3006727, "stId" : "R-HSA-3006727", "displayName" : "RPTOR [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q8N122", "standardIdentifier" : "uniprot:Q8N122", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RPTOR", "KIAA1303", "RAPTOR" ], "parents" : [ 377400 ], "children" : [ ] }, { "dbId" : 8948642, "stId" : "R-HSA-8948642", "displayName" : "miR-106 RISC:VAPA mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1641 ], "parents" : [ ], "children" : [ 8944629, 8945712 ] }, { "dbId" : 4657004, "stId" : "R-HSA-4657004", "displayName" : "HDAC1:HDAC2 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 4657018, 4657015 ], "children" : [ 205021, 205135 ] }, { "dbId" : 8944549, "stId" : "R-HSA-8944549", "displayName" : "miR-22 RISC [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 1654 ], "parents" : [ 8944551 ], "children" : [ 8944541, 8944540 ] }, { "dbId" : 165676, "stId" : "R-HSA-165676", "displayName" : "MLST8 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9BVC4", "standardIdentifier" : "uniprot:Q9BVC4", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MLST8", "GBL", "LST8" ], "parents" : [ 377400 ], "children" : [ ] }, { "dbId" : 8944551, "stId" : "R-HSA-8944551", "displayName" : "miR-22 RISC:PTEN mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1572 ], "parents" : [ ], "children" : [ 8944549, 2318746 ] }, { "dbId" : 4657015, "stId" : "R-HSA-4657015", "displayName" : "CoREST complex [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 6808474 ], "children" : [ 996769, 480506, 4657004, 996766 ] }, { "dbId" : 8944568, "stId" : "R-HSA-8944568", "displayName" : "miR-25 Nonendonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944566 ], "children" : [ 8944560, 210613 ] }, { "dbId" : 4657014, "stId" : "R-HSA-4657014", "displayName" : "(GATAD2A, GATAD2B) [nucleoplasm]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "parents" : [ 4657018 ], "children" : [ 3702079, 3702077 ] }, { "dbId" : 4657013, "stId" : "R-HSA-4657013", "displayName" : "MTA3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9BTC8", "standardIdentifier" : "uniprot:Q9BTC8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MTA3", "KIAA1266" ], "parents" : [ 4657019 ], "children" : [ ] }, { "dbId" : 4657012, "stId" : "R-HSA-4657012", "displayName" : "CHD3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q12873", "standardIdentifier" : "uniprot:Q12873", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CHD3" ], "parents" : [ 4657021 ], "children" : [ ] }, { "dbId" : 8944571, "stId" : "R-HSA-8944571", "displayName" : "miR-25 Endonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944564 ], "children" : [ 8944567, 427772, 427775 ] }, { "dbId" : 8944060, "stId" : "R-HSA-8944060", "displayName" : "JUN:PTEN gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 39 ], "parents" : [ ], "children" : [ 450250, 5632949 ] }, { "dbId" : 4657010, "stId" : "R-HSA-4657010", "displayName" : "MBD3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O95983", "standardIdentifier" : "uniprot:O95983", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MBD3" ], "parents" : [ 4657018 ], "children" : [ ] }, { "dbId" : 212278, "stId" : "R-HSA-212278", "displayName" : "EED [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O75530", "standardIdentifier" : "uniprot:O75530", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "EED" ], "parents" : [ 212285 ], "children" : [ ] }, { "dbId" : 4657009, "stId" : "R-HSA-4657009", "displayName" : "MTA2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O94776", "standardIdentifier" : "uniprot:O94776", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MTA2", "MTA1L1", "PID" ], "parents" : [ 4657019 ], "children" : [ ] }, { "dbId" : 381235, "stId" : "R-ALL-381235", "displayName" : "Ligands of PPARG [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 0, "parents" : [ 2026077 ], "children" : [ 381251, 381254 ] }, { "dbId" : 209723, "stId" : "R-HSA-209723", "displayName" : "AGO2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9UKV8", "standardIdentifier" : "uniprot:Q9UKV8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AGO2", "EIF2C2" ], "parents" : [ 2318741, 8948551, 8944536, 8945710, 8944482, 8944591, 8944668, 8944621, 8944514, 8944567 ], "children" : [ ] }, { "dbId" : 8944560, "stId" : "R-HSA-8944560", "displayName" : "miR-25 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000082", "standardIdentifier" : "mirbase:MI0000082", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR25" ], "parents" : [ 8944567, 8944568 ], "children" : [ ] }, { "dbId" : 5672812, "stId" : "R-HSA-5672812", "displayName" : "MTORC1:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 375 ], "parents" : [ ], "children" : [ 165189, 5653972 ] }, { "dbId" : 4657021, "stId" : "R-HSA-4657021", "displayName" : "Mi-2 [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 4657018 ], "children" : [ 3702078, 4657012 ] }, { "dbId" : 4657019, "stId" : "R-HSA-4657019", "displayName" : "MTA1, MTA2, MTA3 [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 4657018 ], "children" : [ 3465550, 4657009, 4657013 ] }, { "dbId" : 8944564, "stId" : "R-HSA-8944564", "displayName" : "miR-25 RISC [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 1656 ], "parents" : [ 8944565 ], "children" : [ 8944571, 8944566 ] }, { "dbId" : 4657018, "stId" : "R-HSA-4657018", "displayName" : "NuRD complex [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 22 ], "parents" : [ 8943778 ], "children" : [ 4657019, 212223, 4657004, 4657021, 4657010, 4657014, 212227 ] }, { "dbId" : 8944565, "stId" : "R-HSA-8944565", "displayName" : "miR-25 RISC:PTEN mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1573 ], "parents" : [ ], "children" : [ 8944564, 2318746 ] }, { "dbId" : 212285, "stId" : "R-HSA-212285", "displayName" : "PRC2 (EZH2) Core [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8943822 ], "children" : [ 4839773, 212278, 212298, 212217 ] }, { "dbId" : 8944566, "stId" : "R-HSA-8944566", "displayName" : "miR-25 Nonendonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944564 ], "children" : [ 427772, 427775, 8944568 ] }, { "dbId" : 8944567, "stId" : "R-HSA-8944567", "displayName" : "miR-25 Endonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944571 ], "children" : [ 8944560, 209723 ] }, { "dbId" : 939854, "stId" : "R-HSA-939854", "displayName" : "UBB(153-228) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 8944073, "stId" : "R-HSA-8944073", "displayName" : "SNAI1,SNAI2 [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 34 ], "parents" : [ 8944024 ], "children" : [ 2980898, 2980903 ] }, { "dbId" : 381254, "stId" : "R-ALL-381254", "displayName" : "13S-HODE [nucleoplasm]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "34154", "standardIdentifier" : "chebi:34154", "referenceType" : "ReferenceMolecule", "parents" : [ 381235 ], "children" : [ ] }, { "dbId" : 939853, "stId" : "R-HSA-939853", "displayName" : "UBC(153-228) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 8944587, "stId" : "R-HSA-8944587", "displayName" : "miR-93 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000095", "standardIdentifier" : "mirbase:MI0000095", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR93" ], "parents" : [ 8944591, 8944597 ], "children" : [ ] }, { "dbId" : 165190, "stId" : "R-HSA-165190", "displayName" : "RHEB [lysosomal membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q15382", "standardIdentifier" : "uniprot:Q15382", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RHEB", "RHEB2" ], "parents" : [ 165189 ], "children" : [ ] }, { "dbId" : 8938444, "stId" : "R-HSA-8938444", "displayName" : "miR-17 Nonendonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944485 ], "children" : [ 8938454, 427772, 427775 ] }, { "dbId" : 9908177, "stId" : "R-HSA-9908177", "displayName" : "19S regulatory particle [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 68819 ], "children" : [ 9908170, 9908021 ] }, { "dbId" : 381251, "stId" : "R-ALL-381251", "displayName" : "9S-HODE [nucleoplasm]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "34496", "standardIdentifier" : "chebi:34496", "referenceType" : "ReferenceMolecule", "parents" : [ 381235 ], "children" : [ ] }, { "dbId" : 165189, "stId" : "R-HSA-165189", "displayName" : "RHEB:GTP [lysosomal membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5672812 ], "children" : [ 29438, 165190 ] }, { "dbId" : 939849, "stId" : "R-HSA-939849", "displayName" : "RPS27A(1-76) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62979", "standardIdentifier" : "uniprot:P62979", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RPS27A", "UBA80", "UBCEP1" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 8944591, "stId" : "R-HSA-8944591", "displayName" : "miR-93 Endonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944592 ], "children" : [ 209723, 8944587 ] }, { "dbId" : 212298, "stId" : "R-HSA-212298", "displayName" : "EZH2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q15910", "standardIdentifier" : "uniprot:Q15910", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "EZH2", "KMT6" ], "parents" : [ 212285 ], "children" : [ ] }, { "dbId" : 939847, "stId" : "R-HSA-939847", "displayName" : "UBB(1-76) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939844, "stId" : "R-HSA-939844", "displayName" : "UBA52(1-76) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62987", "standardIdentifier" : "uniprot:P62987", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBA52", "UBCEP2" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 205135, "stId" : "R-HSA-205135", "displayName" : "HDAC2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q92769", "standardIdentifier" : "uniprot:Q92769", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HDAC2" ], "parents" : [ 4657004 ], "children" : [ ] }, { "dbId" : 202062, "stId" : "R-HSA-202062", "displayName" : "p-T309,S474-AKT2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P31751", "standardIdentifier" : "uniprot:P31751", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AKT2" ], "parents" : [ 202074 ], "children" : [ ] }, { "dbId" : 8938437, "stId" : "R-HSA-8938437", "displayName" : "miR-17 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000071", "standardIdentifier" : "mirbase:MI0000071", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR17" ], "parents" : [ 8944482, 8938454 ], "children" : [ ] }, { "dbId" : 939870, "stId" : "R-HSA-939870", "displayName" : "UBB(77-152) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 8944600, "stId" : "R-HSA-8944600", "displayName" : "miR-93:PTEN mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1576 ], "parents" : [ ], "children" : [ 2318746, 8944601 ] }, { "dbId" : 939871, "stId" : "R-HSA-939871", "displayName" : "UBC(1-76) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 8944601, "stId" : "R-HSA-8944601", "displayName" : "miR-93 RISC [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 1668 ], "parents" : [ 8944600 ], "children" : [ 8944592, 8944598 ] }, { "dbId" : 939868, "stId" : "R-HSA-939868", "displayName" : "UBC(609-684) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939869, "stId" : "R-HSA-939869", "displayName" : "UBC(77-152) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939866, "stId" : "R-HSA-939866", "displayName" : "UBC(533-608) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 939862, "stId" : "R-HSA-939862", "displayName" : "UBC(457-532) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 8944592, "stId" : "R-HSA-8944592", "displayName" : "miR-93 Endonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944601 ], "children" : [ 427772, 427775, 8944591 ] }, { "dbId" : 202074, "stId" : "R-HSA-202074", "displayName" : "p-T,p-S-AKT [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 1683 ], "parents" : [ ], "children" : [ 198356, 202062, 3009367 ] }, { "dbId" : 939863, "stId" : "R-HSA-939863", "displayName" : "UBC(305-380) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 9908171, "stId" : "R-HSA-9908171", "displayName" : "PSMC2:PSMC1:PSMD2 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9908170 ], "children" : [ 68796, 9907947 ] }, { "dbId" : 8944084, "stId" : "R-HSA-8944084", "displayName" : "EGR1:PTEN gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 11 ], "parents" : [ ], "children" : [ 1031703, 5632949 ] }, { "dbId" : 9908170, "stId" : "R-HSA-9908170", "displayName" : "19S RP base [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9908177 ], "children" : [ 9908171, 9907949, 9907950, 5665939, 68786 ] }, { "dbId" : 8944597, "stId" : "R-HSA-8944597", "displayName" : "miR-93 Nonendonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944598 ], "children" : [ 210613, 8944587 ] }, { "dbId" : 939856, "stId" : "R-HSA-939856", "displayName" : "UBC(381-456) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 8938454, "stId" : "R-HSA-8938454", "displayName" : "miR-17 Nonendonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8938444 ], "children" : [ 8938437, 210613 ] }, { "dbId" : 8944598, "stId" : "R-HSA-8944598", "displayName" : "miR-93 Nonendonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944601 ], "children" : [ 8944597, 427772, 427775 ] }, { "dbId" : 939857, "stId" : "R-HSA-939857", "displayName" : "UBC(229-304) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 68524 ], "children" : [ ] }, { "dbId" : 8944618, "stId" : "R-HSA-8944618", "displayName" : "miR-106 Nonendonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944620 ], "children" : [ 8945703, 210613 ] }, { "dbId" : 8873955, "stId" : "R-HSA-8873955", "displayName" : "OTUD3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q5T2D3", "standardIdentifier" : "uniprot:Q5T2D3", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "OTUD3", "KIAA0459" ], "parents" : [ 8948849 ], "children" : [ ] }, { "dbId" : 8944620, "stId" : "R-HSA-8944620", "displayName" : "miR-106 Nonendonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944629 ], "children" : [ 427772, 427775, 8944618 ] }, { "dbId" : 8944621, "stId" : "R-HSA-8944621", "displayName" : "miR-106 Endonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944622 ], "children" : [ 8945703, 209723 ] }, { "dbId" : 8944622, "stId" : "R-HSA-8944622", "displayName" : "miR-106 Endonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944629 ], "children" : [ 427772, 427775, 8944621 ] }, { "dbId" : 8944097, "stId" : "R-HSA-8944097", "displayName" : "PPARG:Fatty Acid Ligand:PTEN gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 139 ], "parents" : [ ], "children" : [ 2026077, 5632949 ] }, { "dbId" : 8944614, "stId" : "R-HSA-8944614", "displayName" : "miR-106b [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000734", "standardIdentifier" : "mirbase:MI0000734", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR106B" ], "parents" : [ 8945703 ], "children" : [ ] }, { "dbId" : 113518, "stId" : "R-ALL-113518", "displayName" : "H2O [nucleoplasm]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 57 ], "identifier" : "15377", "standardIdentifier" : "chebi:15377", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 8850934, "stId" : "R-HSA-8850934", "displayName" : "PREX2:PTEN,p-3S,2T-PTEN [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 96 ], "parents" : [ ], "children" : [ 8850937, 8850949 ] }, { "dbId" : 69488, "stId" : "R-HSA-69488", "displayName" : "TP53 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04637", "standardIdentifier" : "uniprot:P04637", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TP53", "P53" ], "parents" : [ 3209194 ], "children" : [ ] }, { "dbId" : 8944638, "stId" : "R-HSA-8944638", "displayName" : "miR-214 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000290", "standardIdentifier" : "mirbase:MI0000290", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR214" ], "parents" : [ 8944644 ], "children" : [ ] }, { "dbId" : 8938481, "stId" : "R-HSA-8938481", "displayName" : "miR-20a [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000076", "standardIdentifier" : "mirbase:MI0000076", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR20A" ], "parents" : [ 8945697 ], "children" : [ ] }, { "dbId" : 3009367, "stId" : "R-HSA-3009367", "displayName" : "p-T305,S472-AKT3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9Y243", "standardIdentifier" : "uniprot:Q9Y243", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AKT3", "PKBG" ], "parents" : [ 202074 ], "children" : [ ] }, { "dbId" : 3465550, "stId" : "R-HSA-3465550", "displayName" : "MTA1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q13330", "standardIdentifier" : "uniprot:Q13330", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MTA1" ], "parents" : [ 4657019 ], "children" : [ ] }, { "dbId" : 8944629, "stId" : "R-HSA-8944629", "displayName" : "miR-106 RISC [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 1640 ], "parents" : [ 8948642, 8948650, 8944631 ], "children" : [ 8944622, 8944620 ] }, { "dbId" : 8850937, "stId" : "R-HSA-8850937", "displayName" : "PTEN, p-3S,2T-PTEN [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 92 ], "parents" : [ 8850934 ], "children" : [ 8850936, 199420 ] }, { "dbId" : 8850936, "stId" : "R-HSA-8850936", "displayName" : "p-3S,2T-PTEN [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 88 ], "identifier" : "P60484", "standardIdentifier" : "uniprot:P60484", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PTEN", "MMAC1", "TEP1" ], "parents" : [ 8850937 ], "children" : [ ] }, { "dbId" : 8944631, "stId" : "R-HSA-8944631", "displayName" : "miR-106 RISC:PTEN mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1575 ], "parents" : [ ], "children" : [ 8944629, 2318746 ] }, { "dbId" : 8944392, "stId" : "R-HSA-8944392", "displayName" : "p-T69,T71-ATF2:PTEN gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 264 ], "parents" : [ ], "children" : [ 450243, 5632949 ] }, { "dbId" : 5653972, "stId" : "R-HSA-5653972", "displayName" : "mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5672812 ], "children" : [ 8952725, 377400 ] }, { "dbId" : 5653973, "stId" : "R-HSA-5653973", "displayName" : "RRAGC:GDP [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5653964 ], "children" : [ 29420, 5653949 ] }, { "dbId" : 5653970, "stId" : "R-HSA-5653970", "displayName" : "RRAGD:GDP [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5653964 ], "children" : [ 29420, 5653953 ] }, { "dbId" : 5432789, "stId" : "R-HSA-5432789", "displayName" : "miR-21 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000077", "standardIdentifier" : "mirbase:MI0000077", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR21" ], "parents" : [ 8944700 ], "children" : [ ] }, { "dbId" : 376207, "stId" : "R-HSA-376207", "displayName" : "NR2E1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9Y466", "standardIdentifier" : "uniprot:Q9Y466", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NR2E1", "TLX" ], "parents" : [ 6807075 ], "children" : [ ] }, { "dbId" : 5653978, "stId" : "R-HSA-5653978", "displayName" : "RRAGA:GTP [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5653946 ], "children" : [ 5653577, 29438 ] }, { "dbId" : 9907994, "stId" : "R-HSA-9907994", "displayName" : "PSMD7:PSMD12:PSMD13:PSMD14 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9907993 ], "children" : [ 68794, 68792, 68806, 68722 ] }, { "dbId" : 5653979, "stId" : "R-HSA-5653979", "displayName" : "Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8952725 ], "children" : [ 5653945, 5653921 ] }, { "dbId" : 9907993, "stId" : "R-HSA-9907993", "displayName" : "19S RP Lid Module 1 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9908012 ], "children" : [ 9907994, 68790 ] }, { "dbId" : 5653976, "stId" : "R-HSA-5653976", "displayName" : "RRAGB:GTP [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5653946 ], "children" : [ 29438, 5653579 ] }, { "dbId" : 8943897, "stId" : "R-HSA-8943897", "displayName" : "MECOM [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 25 ], "identifier" : "Q03112", "standardIdentifier" : "uniprot:Q03112", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MECOM", "EVI1", "MDS1", "PRDM3" ], "parents" : [ 8943810, 8943820 ], "children" : [ ] }, { "dbId" : 996766, "stId" : "R-HSA-996766", "displayName" : "RCOR1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9UKL0", "standardIdentifier" : "uniprot:Q9UKL0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RCOR1", "KIAA0071", "RCOR" ], "parents" : [ 4657015 ], "children" : [ ] }, { "dbId" : 5653953, "stId" : "R-HSA-5653953", "displayName" : "RRAGD [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9NQL2", "standardIdentifier" : "uniprot:Q9NQL2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RRAGD" ], "parents" : [ 5653970 ], "children" : [ ] }, { "dbId" : 5653964, "stId" : "R-HSA-5653964", "displayName" : "RRAGC,RRAGD:GDP [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 5653945 ], "children" : [ 5653970, 5653973 ] }, { "dbId" : 3215278, "stId" : "R-HSA-3215278", "displayName" : "USP7 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 60 ], "identifier" : "Q93009", "standardIdentifier" : "uniprot:Q93009", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "USP7", "HAUSP" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 3229073, "stId" : "R-HSA-3229073", "displayName" : "PRC1.4 [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8943822 ], "children" : [ 9007203, 9007200, 9007201, 389122, 389121 ] }, { "dbId" : 8948521, "stId" : "R-HSA-8948521", "displayName" : "miR-19b RISC:PTENP1 mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1596 ], "parents" : [ ], "children" : [ 8945698, 8948558 ] }, { "dbId" : 6781893, "stId" : "R-HSA-6781893", "displayName" : "USP13 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q92995", "standardIdentifier" : "uniprot:Q92995", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "USP13", "ISOT3" ], "parents" : [ 8948849 ], "children" : [ ] }, { "dbId" : 9908021, "stId" : "R-HSA-9908021", "displayName" : "19S RP lid [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9908177 ], "children" : [ 9908012, 68808 ] }, { "dbId" : 5083624, "stId" : "R-HSA-5083624", "displayName" : "CSNK2(A1:A1/A1:A2/A2:A2) [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 201711 ], "children" : [ 5083623, 5083620, 5083621 ] }, { "dbId" : 5083621, "stId" : "R-HSA-5083621", "displayName" : "CSNK2A1 dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5083624 ], "children" : [ 201713 ] }, { "dbId" : 5083620, "stId" : "R-HSA-5083620", "displayName" : "CSNK2A2 dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5083624 ], "children" : [ 201721 ] }, { "dbId" : 5083623, "stId" : "R-HSA-5083623", "displayName" : "CSNK2A1:CSNK2A2 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5083624 ], "children" : [ 201721, 201713 ] }, { "dbId" : 68524, "stId" : "R-HSA-68524", "displayName" : "Ub [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 59 ], "parents" : [ ], "children" : [ 939854, 939853, 939849, 939847, 939844, 939870, 939871, 939868, 939869, 939866, 939862, 939863, 939856, 939857 ] }, { "dbId" : 2318734, "stId" : "R-HSA-2318734", "displayName" : "miR-26A2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000750", "standardIdentifier" : "mirbase:MI0000750", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR26A2" ], "parents" : [ 2318743 ], "children" : [ ] }, { "dbId" : 8944422, "stId" : "R-HSA-8944422", "displayName" : "MAF1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 332 ], "identifier" : "Q9H063", "standardIdentifier" : "uniprot:Q9H063", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MAF1" ], "parents" : [ 8944433 ], "children" : [ ] }, { "dbId" : 996769, "stId" : "R-HSA-996769", "displayName" : "KDM1A [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O60341", "standardIdentifier" : "uniprot:O60341", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "KDM1A", "AOF2", "BHC110", "KDM1", "KIAA0601", "LSD1" ], "parents" : [ 4657015 ], "children" : [ ] }, { "dbId" : 2318732, "stId" : "R-HSA-2318732", "displayName" : "miR-26A1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000083", "standardIdentifier" : "mirbase:MI0000083", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR26A1" ], "parents" : [ 2318743 ], "children" : [ ] }, { "dbId" : 2318739, "stId" : "R-HSA-2318739", "displayName" : "miR-26A Nonendonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 2318738 ], "children" : [ 210613, 2318743 ] }, { "dbId" : 2318738, "stId" : "R-HSA-2318738", "displayName" : "miR-26A Nonendonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 2318737 ], "children" : [ 427772, 427775, 2318739 ] }, { "dbId" : 8948537, "stId" : "R-HSA-8948537", "displayName" : "miR-20 RISC:PTENP1 mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1645 ], "parents" : [ ], "children" : [ 8945698, 8945696 ] }, { "dbId" : 2318737, "stId" : "R-HSA-2318737", "displayName" : "miR-26A RISC [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 1662 ], "parents" : [ 2318750 ], "children" : [ 2318744, 2318738 ] }, { "dbId" : 9908004, "stId" : "R-HSA-9908004", "displayName" : "19S RP lid particle 3 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9908012 ], "children" : [ 68798, 8866674, 68804 ] }, { "dbId" : 2318743, "stId" : "R-HSA-2318743", "displayName" : "miR-26A [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 2318741, 2318739 ], "children" : [ 2318732, 2318734 ] }, { "dbId" : 2318741, "stId" : "R-HSA-2318741", "displayName" : "miR-26A Endonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 2318744 ], "children" : [ 209723, 2318743 ] }, { "dbId" : 113592, "stId" : "R-ALL-113592", "displayName" : "ATP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 371, 2019, 87, 1679 ], "identifier" : "30616", "standardIdentifier" : "chebi:30616", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 8944433, "stId" : "R-HSA-8944433", "displayName" : "MAF1:PTEN gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 333 ], "parents" : [ ], "children" : [ 8944422, 5632949 ] }, { "dbId" : 2318746, "stId" : "R-HSA-2318746", "displayName" : "PTEN mRNA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 8 ], "identifier" : "ENST00000371953", "standardIdentifier" : "ensembl:ENST00000371953", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "PTEN" ], "parents" : [ 8944565, 8948568, 8944631, 8944679, 8944703, 8944600, 8944487, 8945707, 8944551, 8944647, 8944524, 2318750 ], "children" : [ ] }, { "dbId" : 113595, "stId" : "R-HSA-113595", "displayName" : "Ub [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 2049, 2051, 2053, 2041, 2047 ], "parents" : [ ], "children" : [ 939214, 939213, 939239, 939205, 939203, 939232, 939230, 939164, 939165, 939258, 939192, 939191, 939188, 939184 ] }, { "dbId" : 9908012, "stId" : "R-HSA-9908012", "displayName" : "19S RP lid particle 2 [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 9908021 ], "children" : [ 9907993, 9908004 ] }, { "dbId" : 2318744, "stId" : "R-HSA-2318744", "displayName" : "miR-26A Endonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 2318737 ], "children" : [ 427772, 427775, 2318741 ] }, { "dbId" : 2318750, "stId" : "R-HSA-2318750", "displayName" : "PTEN mRNA:miR-26A RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1569 ], "parents" : [ ], "children" : [ 2318746, 2318737 ] }, { "dbId" : 3229071, "stId" : "R-HSA-3229071", "displayName" : "CBX6 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O95503", "standardIdentifier" : "uniprot:O95503", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CBX6" ], "parents" : [ 9007203 ], "children" : [ ] }, { "dbId" : 8944460, "stId" : "R-HSA-8944460", "displayName" : "MAF1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 372 ], "identifier" : "Q9H063", "standardIdentifier" : "uniprot:Q9H063", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MAF1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8948558, "stId" : "R-HSA-8948558", "displayName" : "miR-19b RISC [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 1594 ], "parents" : [ 8948521, 8948610, 8948568 ], "children" : [ 8944512, 8944508 ] }, { "dbId" : 5655441, "stId" : "R-HSA-5655441", "displayName" : "LAMTOR5 [lysosomal membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O43504", "standardIdentifier" : "uniprot:O43504", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LAMTOR5", "HBXIP", "XIP" ], "parents" : [ 5653921 ], "children" : [ ] }, { "dbId" : 8948559, "stId" : "R-HSA-8948559", "displayName" : "miR-19a RISC [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 1598 ], "parents" : [ 8948605, 8948593, 8944524 ], "children" : [ 8948550, 8948548 ] }, { "dbId" : 3640827, "stId" : "R-HSA-3640827", "displayName" : "RNF146 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 1991 ], "identifier" : "Q9NTX7", "standardIdentifier" : "uniprot:Q9NTX7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RNF146" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8948548, "stId" : "R-HSA-8948548", "displayName" : "miR-19a Nonendonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8948559 ], "children" : [ 8948549, 427772, 427775 ] }, { "dbId" : 3640826, "stId" : "R-HSA-3640826", "displayName" : "TNKS1/2 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 1809 ], "parents" : [ ], "children" : [ 3640824, 3640825 ] }, { "dbId" : 8948549, "stId" : "R-HSA-8948549", "displayName" : "miR-19a Nonendonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8948548 ], "children" : [ 210613, 8944504 ] }, { "dbId" : 3640825, "stId" : "R-HSA-3640825", "displayName" : "TNKS [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O95271", "standardIdentifier" : "uniprot:O95271", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TNKS", "PARP5A", "PARPL", "TIN1", "TINF1", "TNKS1" ], "parents" : [ 3640826 ], "children" : [ ] }, { "dbId" : 8948550, "stId" : "R-HSA-8948550", "displayName" : "miR-19a Endonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8948559 ], "children" : [ 8948551, 427772, 427775 ] }, { "dbId" : 3640824, "stId" : "R-HSA-3640824", "displayName" : "TNKS2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9H2K2", "standardIdentifier" : "uniprot:Q9H2K2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "TNKS2", "PARP5B", "TANK2", "TNKL" ], "parents" : [ 3640826 ], "children" : [ ] }, { "dbId" : 8944455, "stId" : "R-HSA-8944455", "displayName" : "p-S60,S68,S75-MAF1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 374 ], "identifier" : "Q9H063", "standardIdentifier" : "uniprot:Q9H063", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MAF1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8948551, "stId" : "R-HSA-8948551", "displayName" : "miR-19a Endonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8948550 ], "children" : [ 209723, 8944504 ] }, { "dbId" : 8948568, "stId" : "R-HSA-8948568", "displayName" : "miR-19b RISC:PTEN mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1580 ], "parents" : [ ], "children" : [ 2318746, 8948558 ] }, { "dbId" : 3209194, "stId" : "R-HSA-3209194", "displayName" : "TP53 Tetramer [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 4 ], "parents" : [ 5632941 ], "children" : [ 69488 ] }, { "dbId" : 201693, "stId" : "R-HSA-201693", "displayName" : "CSNK2B [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P67870", "standardIdentifier" : "uniprot:P67870", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CSNK2B", "CK2N", "G5A" ], "parents" : [ 201711 ], "children" : [ ] }, { "dbId" : 5655432, "stId" : "R-HSA-5655432", "displayName" : "LAMTOR4 [lysosomal membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q0VGL1", "standardIdentifier" : "uniprot:Q0VGL1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LAMTOR4", "C7orf59" ], "parents" : [ 5653921 ], "children" : [ ] }, { "dbId" : 5632949, "stId" : "R-HSA-5632949", "displayName" : "PTEN gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 5 ], "identifier" : "ENSG00000171862", "standardIdentifier" : "ensembl:ENSG00000171862", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "PTEN", "MMAC1", "TEP1" ], "parents" : [ 8943729, 8943810, 8944084, 8944024, 8944097, 8944060, 8943821, 8944433, 8944392, 8943781, 5632941, 6807085 ], "children" : [ ] }, { "dbId" : 8944488, "stId" : "R-HSA-8944488", "displayName" : "miR-17 Endonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944485 ], "children" : [ 8944482, 427772, 427775 ] }, { "dbId" : 8944482, "stId" : "R-HSA-8944482", "displayName" : "miR-17 Endonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944488 ], "children" : [ 8938437, 209723 ] }, { "dbId" : 5653949, "stId" : "R-HSA-5653949", "displayName" : "RRAGC [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9HB90", "standardIdentifier" : "uniprot:Q9HB90", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RRAGC" ], "parents" : [ 5653973 ], "children" : [ ] }, { "dbId" : 201711, "stId" : "R-HSA-201711", "displayName" : "Casein kinase II [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 90 ], "parents" : [ ], "children" : [ 201693, 5083624 ] }, { "dbId" : 5653946, "stId" : "R-HSA-5653946", "displayName" : "RRAGA, RRAGB:GTP [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 5653945 ], "children" : [ 5653976, 5653978 ] }, { "dbId" : 8948580, "stId" : "R-HSA-8948580", "displayName" : "miR-17 RISC:CNOT6L mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1591 ], "parents" : [ ], "children" : [ 8944485, 8945708 ] }, { "dbId" : 8944485, "stId" : "R-HSA-8944485", "displayName" : "miR-17 RISC [cytosol]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 1586 ], "parents" : [ 8948581, 8948580, 8944487 ], "children" : [ 8944488, 8938444 ] }, { "dbId" : 8948581, "stId" : "R-HSA-8948581", "displayName" : "miR-17 RISC:VAPA mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1588 ], "parents" : [ ], "children" : [ 8944485, 8945712 ] }, { "dbId" : 5653945, "stId" : "R-HSA-5653945", "displayName" : "RagA,B:GTP:RagC,D:GDP [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5653979 ], "children" : [ 5653946, 5653964 ] }, { "dbId" : 8944487, "stId" : "R-HSA-8944487", "displayName" : "miR-17 RISC:PTEN mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1570 ], "parents" : [ ], "children" : [ 8944485, 2318746 ] }, { "dbId" : 8944504, "stId" : "R-HSA-8944504", "displayName" : "miR-19a [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "MI0000073", "standardIdentifier" : "mirbase:MI0000073", "referenceType" : "ReferenceRNASequence", "geneNames" : [ "MIR19A" ], "parents" : [ 8948551, 8948549 ], "children" : [ ] }, { "dbId" : 201713, "stId" : "R-HSA-201713", "displayName" : "CSNK2A1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P68400", "standardIdentifier" : "uniprot:P68400", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CSNK2A1", "CK2A1" ], "parents" : [ 5083623, 5083621 ], "children" : [ ] }, { "dbId" : 389111, "stId" : "R-HSA-389111", "displayName" : "PHC1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P78364", "standardIdentifier" : "uniprot:P78364", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PHC1", "EDR1", "PH1" ], "parents" : [ 9007200 ], "children" : [ ] }, { "dbId" : 389110, "stId" : "R-HSA-389110", "displayName" : "CBX2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q14781", "standardIdentifier" : "uniprot:Q14781", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CBX2" ], "parents" : [ 9007203 ], "children" : [ ] }, { "dbId" : 8944507, "stId" : "R-HSA-8944507", "displayName" : "miR-19b Nonendonucleolytic Minimal RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8944508 ], "children" : [ 8945717, 210613 ] }, { "dbId" : 8944508, "stId" : "R-HSA-8944508", "displayName" : "miR-19b Nonendonucleolytic RISC [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8948558 ], "children" : [ 427772, 427775, 8944507 ] }, { "dbId" : 8866674, "stId" : "R-HSA-8866674", "displayName" : "SEM1 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P60896", "standardIdentifier" : "uniprot:P60896", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SEM1", "C7orf76", "DSS1", "SHFDG1", "SHFM1" ], "parents" : [ 9908004 ], "children" : [ ] }, { "dbId" : 8948605, "stId" : "R-HSA-8948605", "displayName" : "miR-19a RISC:CNOT6L mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1609 ], "parents" : [ ], "children" : [ 8948559, 8945708 ] }, { "dbId" : 5653921, "stId" : "R-HSA-5653921", "displayName" : "Ragulator [lysosomal membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 5653979 ], "children" : [ 5655432, 5653581, 5653583, 5653582, 5655441 ] }, { "dbId" : 5632941, "stId" : "R-HSA-5632941", "displayName" : "TP53 Tetramer:PTEN Gene [nucleoplasm]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 6 ], "parents" : [ ], "children" : [ 3209194, 5632949 ] }, { "dbId" : 389117, "stId" : "R-HSA-389117", "displayName" : "CBX8 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9HC52", "standardIdentifier" : "uniprot:Q9HC52", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CBX8", "PC3", "RC1" ], "parents" : [ 9007203 ], "children" : [ ] }, { "dbId" : 389116, "stId" : "R-HSA-389116", "displayName" : "PHC3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q8NDX5", "standardIdentifier" : "uniprot:Q8NDX5", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PHC3", "EDR3", "PH3" ], "parents" : [ 9007200 ], "children" : [ ] }, { "dbId" : 8948593, "stId" : "R-HSA-8948593", "displayName" : "miR-19a RISC:VAPA mRNA [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1599 ], "parents" : [ ], "children" : [ 8945712, 8948559 ] }, { "dbId" : 201721, "stId" : "R-HSA-201721", "displayName" : "CSNK2A2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P19784", "standardIdentifier" : "uniprot:P19784", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CSNK2A2", "CK2A2" ], "parents" : [ 5083623, 5083620 ], "children" : [ ] }, { "dbId" : 389119, "stId" : "R-HSA-389119", "displayName" : "RNF2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q99496", "standardIdentifier" : "uniprot:Q99496", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RNF2", "BAP1", "DING", "HIPI3", "RING1B" ], "parents" : [ 9007201 ], "children" : [ ] }, { "dbId" : 6808476, "stId" : "R-HSA-6808476", "displayName" : "HDAC3,5,7 [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 6808474 ], "children" : [ 3004534, 3004533, 442464 ] }, { "dbId" : 389118, "stId" : "R-HSA-389118", "displayName" : "CBX4 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O00257", "standardIdentifier" : "uniprot:O00257", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CBX4" ], "parents" : [ 9007203 ], "children" : [ ] }, { "dbId" : 389113, "stId" : "R-HSA-389113", "displayName" : "RING1 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q06587", "standardIdentifier" : "uniprot:Q06587", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RING1", "RING1A", "RNF1" ], "parents" : [ 9007201 ], "children" : [ ] }, { "dbId" : 6808474, "stId" : "R-HSA-6808474", "displayName" : "CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "parents" : [ 6807075 ], "children" : [ 6808476, 6807083, 4657015 ] }, { "dbId" : 389112, "stId" : "R-HSA-389112", "displayName" : "PHC2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q8IXK0", "standardIdentifier" : "uniprot:Q8IXK0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PHC2", "EDR2", "PH2" ], "parents" : [ 9007200 ], "children" : [ ] } ], "edges" : [ { "dbId" : 8944522, "stId" : "R-HSA-8944522", "displayName" : "miR-19a microRNA binds PTEN mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944104 ], "following" : [ 8944497 ], "inputs" : [ 2318746, 8948559 ], "outputs" : [ 8944524 ], "efs" : [ ], "inhibitors" : [ 8948605, 8948593 ], "diagramIds" : [ 1612 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944650, "stId" : "R-HSA-8944650", "displayName" : "miR-214 microRNA binds PTEN mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944104 ], "following" : [ 8944497 ], "inputs" : [ 8944643, 2318746 ], "outputs" : [ 8944647 ], "efs" : [ ], "diagramIds" : [ 1676 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 2318752, "stId" : "R-HSA-2318752", "displayName" : "miR-26A microRNAs bind PTEN mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944104 ], "following" : [ 8944497 ], "inputs" : [ 2318746, 2318737 ], "outputs" : [ 2318750 ], "efs" : [ ], "diagramIds" : [ 1661 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944397, "stId" : "R-HSA-8944397", "displayName" : "p-T69,T71-ATF2 binds PTEN gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8944104 ], "inputs" : [ 450243, 5632949 ], "outputs" : [ 8944392 ], "efs" : [ ], "diagramIds" : [ 262 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948621, "stId" : "R-HSA-8948621", "displayName" : "miR-20 microRNAs bind VAPA mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8945712, 8945696 ], "outputs" : [ 8948624 ], "efs" : [ ], "diagramIds" : [ 1634 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8850945, "stId" : "R-HSA-8850945", "displayName" : "Casein kinase II phosphorylates PTEN", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944497 ], "following" : [ 8850961 ], "inputs" : [ 199420, 113592 ], "outputs" : [ 8850936, 29370 ], "catalysts" : [ 201711 ], "efs" : [ ], "diagramIds" : [ 86 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948623, "stId" : "R-HSA-8948623", "displayName" : "miR-20 microRNAs bind CNOT6L mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8945696, 8945708 ], "outputs" : [ 8948622 ], "efs" : [ ], "diagramIds" : [ 1637 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948612, "stId" : "R-HSA-8948612", "displayName" : "miR-19b microRNA binds CNOT6L mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8948558, 8945708 ], "outputs" : [ 8948610 ], "efs" : [ ], "diagramIds" : [ 1610 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944026, "stId" : "R-HSA-8944026", "displayName" : "SNAI1,SNAI2 bind the PTEN gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8944104 ], "inputs" : [ 8944073, 5632949 ], "outputs" : [ 8944024 ], "efs" : [ ], "diagramIds" : [ 33 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944538, "stId" : "R-HSA-8944538", "displayName" : "miR-22 microRNA binds PTEN mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944104 ], "following" : [ 8944497 ], "inputs" : [ 8944549, 2318746 ], "outputs" : [ 8944551 ], "efs" : [ ], "diagramIds" : [ 1653 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8850961, "stId" : "R-HSA-8850961", "displayName" : "PREX2 binds PTEN and inhibits it", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8850945 ], "inputs" : [ 8850937, 8850949 ], "outputs" : [ 8850934 ], "efs" : [ ], "diagramIds" : [ 91 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948757, "stId" : "R-HSA-8948757", "displayName" : "AKT phosphorylates MKRN1", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8948775 ], "inputs" : [ 113592, 976042 ], "outputs" : [ 8948758, 29370 ], "catalysts" : [ 202074 ], "efs" : [ ], "diagramIds" : [ 1678 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948651, "stId" : "R-HSA-8948651", "displayName" : "miR-106a,(miR106b) microRNA binds CNOT6L mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8944629, 8945708 ], "outputs" : [ 8948650 ], "efs" : [ ], "diagramIds" : [ 1642 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944684, "stId" : "R-HSA-8944684", "displayName" : "miR-205 microRNA binds PTEN mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944104 ], "following" : [ 8944497 ], "inputs" : [ 8944674, 2318746 ], "outputs" : [ 8944679 ], "efs" : [ ], "diagramIds" : [ 1673 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948524, "stId" : "R-HSA-8948524", "displayName" : "PTENP1 mRNA binds miR-19b RISC", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8945698, 8948558 ], "outputs" : [ 8948521 ], "efs" : [ ], "diagramIds" : [ 1593 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6807106, "stId" : "R-HSA-6807106", "displayName" : "PTEN undergoes monoubiquitination", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 6807105 ], "inputs" : [ 199420, 113595 ], "outputs" : [ 6807247 ], "catalysts" : [ 6807260 ], "efs" : [ ], "diagramIds" : [ 50 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8945709, "stId" : "R-HSA-8945709", "displayName" : "miR-20 microRNAs bind PTEN mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944104 ], "following" : [ 8944497 ], "inputs" : [ 2318746, 8945696 ], "outputs" : [ 8945707 ], "efs" : [ ], "inhibitors" : [ 8948537, 8948624, 8948622 ], "diagramIds" : [ 1644 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6807105, "stId" : "R-HSA-6807105", "displayName" : "Monoubiquitinated PTEN translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 6807106 ], "following" : [ 6807118 ], "inputs" : [ 6807247 ], "outputs" : [ 6807264 ], "efs" : [ ], "diagramIds" : [ 54 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944047, "stId" : "R-HSA-8944047", "displayName" : "JUN binds the PTEN gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8944104 ], "inputs" : [ 450250, 5632949 ], "outputs" : [ 8944060 ], "efs" : [ ], "activators" : [ 1268261 ], "diagramIds" : [ 37 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6807118, "stId" : "R-HSA-6807118", "displayName" : "USP7 deubiquitinates monoubiquitinated PTEN", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 6807105 ], "following" : [ 6807126 ], "inputs" : [ 113518, 6807264 ], "outputs" : [ 6807273, 68524 ], "catalysts" : [ 3215278 ], "efs" : [ ], "inhibitors" : [ 1031706 ], "diagramIds" : [ 56 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948641, "stId" : "R-HSA-8948641", "displayName" : "miR-106 microRNAs bind VAPA mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8944629, 8945712 ], "outputs" : [ 8948642 ], "efs" : [ ], "diagramIds" : [ 1639 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944420, "stId" : "R-HSA-8944420", "displayName" : "MAF1 binds the PTEN gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944457 ], "following" : [ 8944104 ], "inputs" : [ 8944422, 5632949 ], "outputs" : [ 8944433 ], "efs" : [ ], "diagramIds" : [ 331 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8943780, "stId" : "R-HSA-8943780", "displayName" : "SALL4 recruits NuRD to PTEN gene", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8943728 ], "following" : [ 8944104 ], "inputs" : [ 4657018, 8943729 ], "outputs" : [ 8943781 ], "efs" : [ ], "diagramIds" : [ 21 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948775, "stId" : "R-HSA-8948775", "displayName" : "MKRN1 polyubiquitinates PTEN", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8948757, 8944497 ], "following" : [ 8850992 ], "inputs" : [ 199420, 113595 ], "outputs" : [ 8948777 ], "catalysts" : [ 8948758 ], "efs" : [ ], "diagramIds" : [ 1741 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948536, "stId" : "R-HSA-8948536", "displayName" : "PTENP1 mRNA binds miR-20 RISC", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8945698, 8945696 ], "outputs" : [ 8948537 ], "efs" : [ ], "diagramIds" : [ 1675 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6807126, "stId" : "R-HSA-6807126", "displayName" : "Deubiquitinated PTEN translocates to the cytosol", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 6807118 ], "inputs" : [ 6807273 ], "outputs" : [ 199420 ], "efs" : [ ], "diagramIds" : [ 62 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944569, "stId" : "R-HSA-8944569", "displayName" : "miR-25 microRNA binds PTEN mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944104 ], "following" : [ 8944497 ], "inputs" : [ 8944564, 2318746 ], "outputs" : [ 8944565 ], "efs" : [ ], "diagramIds" : [ 1655 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8850997, "stId" : "R-HSA-8850997", "displayName" : "TRIM27 binds PTEN", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944497 ], "following" : [ 8851011 ], "inputs" : [ 199420, 8851002 ], "outputs" : [ 8851000 ], "efs" : [ ], "diagramIds" : [ 100 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8850992, "stId" : "R-HSA-8850992", "displayName" : "Proteasome degrades polyubiquitinated PTEN", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8948775, 6807134, 8948832 ], "inputs" : [ 8948842 ], "outputs" : [ 113595 ], "catalysts" : [ 68819 ], "efs" : [ ], "diagramIds" : [ 70 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6807134, "stId" : "R-HSA-6807134", "displayName" : "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944497 ], "following" : [ 8850992, 6807206 ], "inputs" : [ 199420, 113595 ], "outputs" : [ 6807280 ], "catalysts" : [ 6807286 ], "efs" : [ ], "diagramIds" : [ 66 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6807206, "stId" : "R-HSA-6807206", "displayName" : "USP13 and OTUD3 deubiquitinate PTEN", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 6807134 ], "inputs" : [ 29356, 8948784 ], "outputs" : [ 199420, 113595 ], "catalysts" : [ 8948849 ], "efs" : [ ], "diagramIds" : [ 72 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944457, "stId" : "R-HSA-8944457", "displayName" : "MAF1 translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8944454 ], "following" : [ 8944420 ], "inputs" : [ 8944460 ], "outputs" : [ 8944422 ], "efs" : [ ], "inhibitors" : [ 5672812 ], "diagramIds" : [ 397 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8943817, "stId" : "R-HSA-8943817", "displayName" : "MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8943811 ], "following" : [ 8944104 ], "inputs" : [ 8943810, 8943822 ], "outputs" : [ 8943821 ], "efs" : [ ], "diagramIds" : [ 27 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6807077, "stId" : "R-HSA-6807077", "displayName" : "NR2E1 associated with transcription repressors binds PTEN promoter", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8944104 ], "inputs" : [ 6807075, 5632949 ], "outputs" : [ 6807085 ], "efs" : [ ], "diagramIds" : [ 14 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8851011, "stId" : "R-HSA-8851011", "displayName" : "TRIM27 polyubiquitinates PTEN", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8850997 ], "inputs" : [ 8851000, 113595 ], "outputs" : [ 8851002, 8851009 ], "catalysts" : [ 8851000 ], "efs" : [ ], "diagramIds" : [ 103 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944078, "stId" : "R-HSA-8944078", "displayName" : "EGR1 binds the PTEN gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8944104 ], "inputs" : [ 1031703, 5632949 ], "outputs" : [ 8944084 ], "efs" : [ ], "diagramIds" : [ 9 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948800, "stId" : "R-HSA-8948800", "displayName" : "TNKS and TNKS2 PARylate PTEN", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944497 ], "following" : [ 8948832 ], "inputs" : [ 199420, 29360 ], "outputs" : [ 197277, 8948798 ], "catalysts" : [ 3640826 ], "efs" : [ ], "diagramIds" : [ 1853 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944706, "stId" : "R-HSA-8944706", "displayName" : "miR-21 nonendonucleolytic RISC binds PTEN mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944104 ], "following" : [ 8944497 ], "inputs" : [ 2318746, 8944705 ], "outputs" : [ 8944703 ], "efs" : [ ], "diagramIds" : [ 1651 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8943811, "stId" : "R-HSA-8943811", "displayName" : "MECOM (EVI1) binds the PTEN gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8943817 ], "inputs" : [ 8943897, 5632949 ], "outputs" : [ 8943810 ], "efs" : [ ], "diagramIds" : [ 24 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944454, "stId" : "R-HSA-8944454", "displayName" : "mTORC1 phosphorylates MAF1", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8944457 ], "inputs" : [ 113592, 8944460 ], "outputs" : [ 8944455, 29370 ], "catalysts" : [ 5672812 ], "efs" : [ ], "diagramIds" : [ 370 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948569, "stId" : "R-HSA-8948569", "displayName" : "miR-19b microRNA binds PTEN mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944104 ], "following" : [ 8944497 ], "inputs" : [ 2318746, 8948558 ], "outputs" : [ 8948568 ], "efs" : [ ], "inhibitors" : [ 8948521, 8948610 ], "diagramIds" : [ 1613 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944599, "stId" : "R-HSA-8944599", "displayName" : "miR-93 microRNA binds PTEN mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944104 ], "following" : [ 8944497 ], "inputs" : [ 2318746, 8944601 ], "outputs" : [ 8944600 ], "efs" : [ ], "diagramIds" : [ 1667 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944104, "stId" : "R-HSA-8944104", "displayName" : "PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8943817, 6807077, 8944026, 8944397, 8944078, 8944047, 8944099, 8943780, 8944420, 5632939 ], "following" : [ 8944599, 8944483, 8944706, 8945709, 8944684, 8944650, 8944538, 8944522, 8944569, 8948569, 8944632, 2318752 ], "inputs" : [ 5632949 ], "outputs" : [ 2318746 ], "efs" : [ ], "inhibitors" : [ 6807085, 8943781, 8943821, 8944060, 8944024 ], "activators" : [ 5632941, 8944392, 8944433, 8944097, 8944084 ], "diagramIds" : [ 140 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8847968, "stId" : "R-HSA-8847968", "displayName" : "PTEN binds FRK", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944497 ], "following" : [ 8847977 ], "inputs" : [ 199420, 8847965 ], "outputs" : [ 8847960 ], "efs" : [ ], "diagramIds" : [ 79 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948832, "stId" : "R-HSA-8948832", "displayName" : "RNF146 polyubiquitinates PARylated PTEN", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8948800 ], "following" : [ 8850992 ], "inputs" : [ 113595, 8948798 ], "outputs" : [ 8948841 ], "catalysts" : [ 3640827 ], "efs" : [ ], "diagramIds" : [ 1989 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944099, "stId" : "R-HSA-8944099", "displayName" : "Activated PPARG binds PTEN gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8944104 ], "inputs" : [ 2026077, 5632949 ], "outputs" : [ 8944097 ], "efs" : [ ], "diagramIds" : [ 137 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944483, "stId" : "R-HSA-8944483", "displayName" : "miR-17 microRNA binds PTEN mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944104 ], "following" : [ 8944497 ], "inputs" : [ 8944485, 2318746 ], "outputs" : [ 8944487 ], "efs" : [ ], "inhibitors" : [ 8948581, 8948580 ], "diagramIds" : [ 1592 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8847977, "stId" : "R-HSA-8847977", "displayName" : "FRK phosphorylates PTEN", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8847968 ], "inputs" : [ 8847960, 113592 ], "outputs" : [ 8847980, 29370, 8847965 ], "catalysts" : [ 8847960 ], "efs" : [ ], "diagramIds" : [ 2018 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948582, "stId" : "R-HSA-8948582", "displayName" : "miR-17 microRNA binds VAPA mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8944485, 8945712 ], "outputs" : [ 8948581 ], "efs" : [ ], "diagramIds" : [ 1585 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948583, "stId" : "R-HSA-8948583", "displayName" : "miR-17 microRNA binds CNOT6L mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8944485, 8945708 ], "outputs" : [ 8948580 ], "efs" : [ ], "diagramIds" : [ 1589 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944632, "stId" : "R-HSA-8944632", "displayName" : "miR-106 microRNAs bind PTEN mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8944104 ], "following" : [ 8944497 ], "inputs" : [ 8944629, 2318746 ], "outputs" : [ 8944631 ], "efs" : [ ], "inhibitors" : [ 8948642, 8948650 ], "diagramIds" : [ 1646 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948602, "stId" : "R-HSA-8948602", "displayName" : "miR-19a microRNA binds CNOT6L mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8948559, 8945708 ], "outputs" : [ 8948605 ], "efs" : [ ], "diagramIds" : [ 1608 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8943728, "stId" : "R-HSA-8943728", "displayName" : "SALL4 binds the PTEN gene promoter", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8943780 ], "inputs" : [ 452644, 5632949 ], "outputs" : [ 8943729 ], "efs" : [ ], "diagramIds" : [ 18 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8944497, "stId" : "R-HSA-8944497", "displayName" : "PTEN mRNA translation is negatively regulated by microRNAs", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8944632, 8948569, 8944569, 8944522, 8944538, 8944650, 2318752, 8944684, 8945709, 8944706, 8944483, 8944599 ], "following" : [ 8948775, 8948800, 8847968, 8850945, 8850997, 6807134 ], "inputs" : [ 2318746 ], "outputs" : [ 199420 ], "efs" : [ ], "inhibitors" : [ 8944524, 8944647, 8944551, 8945707, 8944487, 2318750, 8944600, 8944703, 8944679, 8944631, 8948568, 8944565 ], "diagramIds" : [ 1568 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8948594, "stId" : "R-HSA-8948594", "displayName" : "miR-19a microRNA binds VAPA mRNA", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8945712, 8948559 ], "outputs" : [ 8948593 ], "efs" : [ ], "diagramIds" : [ 1597 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 5632939, "stId" : "R-HSA-5632939", "displayName" : "TP53 binds the PTEN promoter", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8944104 ], "inputs" : [ 3209194, 5632949 ], "outputs" : [ 5632941 ], "efs" : [ ], "diagramIds" : [ 3 ], "entityFunctionalStatus" : [ ] } ], "subpathways" : [ { "dbId" : 8943723, "stId" : "R-HSA-8943723", "displayName" : "Regulation of PTEN mRNA translation", "events" : [ 8944522, 8944650, 2318752, 8944684, 8945709, 8944706, 8944483, 8944632, 8948569, 8944569, 8944538, 8948536, 8948602, 8948651, 8948524, 8948621, 8948623, 8948641, 8948594, 8948612, 8948582, 8948583, 8944497, 8944599 ] }, { "dbId" : 8948700, "stId" : "R-HSA-8948700", "displayName" : "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "events" : [ 8948536, 8948602, 8948651, 8948524, 8948621, 8948623, 8948641, 8948594, 8948612, 8948582, 8948583 ] }, { "dbId" : 8948751, "stId" : "R-HSA-8948751", "displayName" : "Regulation of PTEN stability and activity", "events" : [ 6807206, 8851011, 8850945, 8847968, 8948800, 8948832, 8847977, 8948775, 8850997, 8850961, 8850992, 6807134, 8948757 ] }, { "dbId" : 8943724, "stId" : "R-HSA-8943724", "displayName" : "Regulation of PTEN gene transcription", "events" : [ 5632939, 8943728, 8944026, 8944454, 8944420, 8943780, 8943811, 8944099, 8944047, 8944078, 8944397, 6807077, 8944457, 8943817, 8944104 ] }, { "dbId" : 8948747, "stId" : "R-HSA-8948747", "displayName" : "Regulation of PTEN localization", "events" : [ 6807126, 6807106, 6807105, 6807118 ] } ] }