{
  "dbId" : 6802952,
  "stableId" : "R-HSA-6802952",
  "displayName" : "Signaling by BRAF and RAF1 fusions",
  "forNormalDraw" : false,
  "nodes" : [ {
    "id" : 3073,
    "reactomeId" : 5672665,
    "displayName" : "p-S338,Y341,T491,S494,S621 RAF1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3875,
      "y" : 379
    },
    "isFadeOut" : true,
    "minX" : 3803,
    "maxX" : 3988,
    "minY" : 350,
    "maxY" : 402,
    "prop" : {
      "x" : 3803,
      "y" : 356,
      "width" : 144,
      "height" : 46
    },
    "innerProp" : {
      "x" : 3803,
      "y" : 362,
      "width" : 144,
      "height" : 40
    },
    "textPosition" : {
      "x" : 3812,
      "y" : 361
    },
    "nodeAttachments" : [ {
      "reactomeId" : 109785,
      "label" : "P",
      "description" : "O-phospho-L-serine at 621",
      "shape" : {
        "a" : {
          "x" : 3813,
          "y" : 350
        },
        "b" : {
          "x" : 3825,
          "y" : 362
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 3819,
          "y" : 356
        }
      }
    }, {
      "reactomeId" : 109791,
      "label" : "P",
      "description" : "O4'-phospho-L-tyrosine at 341",
      "shape" : {
        "a" : {
          "x" : 3829,
          "y" : 350
        },
        "b" : {
          "x" : 3841,
          "y" : 362
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 3835,
          "y" : 356
        }
      }
    }, {
      "reactomeId" : 444234,
      "label" : "P",
      "description" : "O-phospho-L-serine at 338",
      "shape" : {
        "a" : {
          "x" : 3845,
          "y" : 350
        },
        "b" : {
          "x" : 3857,
          "y" : 362
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 3851,
          "y" : 356
        }
      }
    }, {
      "reactomeId" : 5672662,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 491",
      "shape" : {
        "a" : {
          "x" : 3861,
          "y" : 350
        },
        "b" : {
          "x" : 3873,
          "y" : 362
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 3867,
          "y" : 356
        }
      }
    }, {
      "reactomeId" : 5672663,
      "label" : "P",
      "description" : "O-phospho-L-serine at 494",
      "shape" : {
        "a" : {
          "x" : 3877,
          "y" : 350
        },
        "b" : {
          "x" : 3889,
          "y" : 362
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 3883,
          "y" : 356
        }
      }
    } ],
    "connectors" : [ {
      "edgeId" : 3072,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3950,
          "y" : 379
        },
        "to" : {
          "x" : 3988,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3077,
    "reactomeId" : 5675193,
    "displayName" : "hyperphosphorylated RAF1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4170,
      "y" : 376
    },
    "isFadeOut" : true,
    "minX" : 4051,
    "maxX" : 4391,
    "minY" : 291,
    "maxY" : 411,
    "prop" : {
      "x" : 4081,
      "y" : 341,
      "width" : 178,
      "height" : 70
    },
    "innerProp" : {
      "x" : 4081,
      "y" : 347,
      "width" : 172,
      "height" : 64
    },
    "textPosition" : {
      "x" : 4082,
      "y" : 365
    },
    "nodeAttachments" : [ {
      "reactomeId" : 109785,
      "label" : "P",
      "description" : "O-phospho-L-serine at 621",
      "shape" : {
        "a" : {
          "x" : 4091,
          "y" : 335
        },
        "b" : {
          "x" : 4103,
          "y" : 347
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4097,
          "y" : 341
        }
      }
    }, {
      "reactomeId" : 109791,
      "label" : "P",
      "description" : "O4'-phospho-L-tyrosine at 341",
      "shape" : {
        "a" : {
          "x" : 4107,
          "y" : 335
        },
        "b" : {
          "x" : 4119,
          "y" : 347
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4113,
          "y" : 341
        }
      }
    }, {
      "reactomeId" : 444234,
      "label" : "P",
      "description" : "O-phospho-L-serine at 338",
      "shape" : {
        "a" : {
          "x" : 4123,
          "y" : 335
        },
        "b" : {
          "x" : 4135,
          "y" : 347
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4129,
          "y" : 341
        }
      }
    }, {
      "reactomeId" : 5672662,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 491",
      "shape" : {
        "a" : {
          "x" : 4139,
          "y" : 335
        },
        "b" : {
          "x" : 4151,
          "y" : 347
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4145,
          "y" : 341
        }
      }
    }, {
      "reactomeId" : 5672663,
      "label" : "P",
      "description" : "O-phospho-L-serine at 494",
      "shape" : {
        "a" : {
          "x" : 4155,
          "y" : 335
        },
        "b" : {
          "x" : 4167,
          "y" : 347
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4161,
          "y" : 341
        }
      }
    }, {
      "reactomeId" : 109784,
      "label" : "P",
      "description" : "O-phospho-L-serine at 259",
      "shape" : {
        "a" : {
          "x" : 4171,
          "y" : 335
        },
        "b" : {
          "x" : 4183,
          "y" : 347
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4177,
          "y" : 341
        }
      }
    }, {
      "reactomeId" : 5675178,
      "label" : "P",
      "description" : "O-phospho-L-serine at 29",
      "shape" : {
        "a" : {
          "x" : 4187,
          "y" : 335
        },
        "b" : {
          "x" : 4199,
          "y" : 347
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4193,
          "y" : 341
        }
      }
    }, {
      "reactomeId" : 5675183,
      "label" : "P",
      "description" : "O-phospho-L-serine at 43",
      "shape" : {
        "a" : {
          "x" : 4203,
          "y" : 335
        },
        "b" : {
          "x" : 4215,
          "y" : 347
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4209,
          "y" : 341
        }
      }
    }, {
      "reactomeId" : 5675179,
      "label" : "P",
      "description" : "O-phospho-L-serine at 296",
      "shape" : {
        "a" : {
          "x" : 4219,
          "y" : 335
        },
        "b" : {
          "x" : 4231,
          "y" : 347
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4225,
          "y" : 341
        }
      }
    }, {
      "reactomeId" : 5675182,
      "label" : "P",
      "description" : "O-phospho-L-serine at 301",
      "shape" : {
        "a" : {
          "x" : 4235,
          "y" : 335
        },
        "b" : {
          "x" : 4247,
          "y" : 347
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4241,
          "y" : 341
        }
      }
    }, {
      "reactomeId" : 5675185,
      "label" : "P",
      "description" : "O-phospho-L-serine at 642",
      "shape" : {
        "a" : {
          "x" : 4253,
          "y" : 351
        },
        "b" : {
          "x" : 4265,
          "y" : 363
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4259,
          "y" : 357
        }
      }
    } ],
    "connectors" : [ {
      "edgeId" : 3072,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4078,
          "y" : 378
        },
        "to" : {
          "x" : 4051,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4071,
          "y" : 382
        },
        "b" : {
          "x" : 4078,
          "y" : 378
        },
        "c" : {
          "x" : 4071,
          "y" : 374
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4071,
          "y" : 374
        }
      }
    }, {
      "edgeId" : 3472,
      "type" : "ACTIVATOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4262,
          "y" : 374
        },
        "to" : {
          "x" : 4342,
          "y" : 374
        }
      }, {
        "from" : {
          "x" : 4342,
          "y" : 374
        },
        "to" : {
          "x" : 4391,
          "y" : 291
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4391,
          "y" : 299
        },
        "b" : {
          "x" : 4391,
          "y" : 291
        },
        "c" : {
          "x" : 4384,
          "y" : 295
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 4384,
          "y" : 295
        }
      }
    } ]
  }, {
    "id" : 3079,
    "reactomeId" : 5672679,
    "displayName" : "p-S446,T599,S602,S729 BRAF",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3824,
      "y" : 455
    },
    "isFadeOut" : true,
    "minX" : 3764,
    "maxX" : 3916,
    "minY" : 423,
    "maxY" : 481,
    "prop" : {
      "x" : 3764,
      "y" : 429,
      "width" : 120,
      "height" : 52
    },
    "innerProp" : {
      "x" : 3764,
      "y" : 435,
      "width" : 120,
      "height" : 46
    },
    "textPosition" : {
      "x" : 3768,
      "y" : 437
    },
    "nodeAttachments" : [ {
      "reactomeId" : 5672668,
      "label" : "P",
      "description" : "O-phospho-L-serine at 446",
      "shape" : {
        "a" : {
          "x" : 3774,
          "y" : 423
        },
        "b" : {
          "x" : 3786,
          "y" : 435
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 3780,
          "y" : 429
        }
      }
    }, {
      "reactomeId" : 5672670,
      "label" : "P",
      "description" : "O-phospho-L-serine at 729",
      "shape" : {
        "a" : {
          "x" : 3790,
          "y" : 423
        },
        "b" : {
          "x" : 3802,
          "y" : 435
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 3796,
          "y" : 429
        }
      }
    }, {
      "reactomeId" : 5672675,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 599",
      "shape" : {
        "a" : {
          "x" : 3806,
          "y" : 423
        },
        "b" : {
          "x" : 3818,
          "y" : 435
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 3812,
          "y" : 429
        }
      }
    }, {
      "reactomeId" : 5672677,
      "label" : "P",
      "description" : "O-phospho-L-serine at 602",
      "shape" : {
        "a" : {
          "x" : 3822,
          "y" : 423
        },
        "b" : {
          "x" : 3834,
          "y" : 435
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 3828,
          "y" : 429
        }
      }
    } ],
    "connectors" : [ {
      "edgeId" : 3078,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3887,
          "y" : 451
        },
        "to" : {
          "x" : 3916,
          "y" : 450
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3081,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3904,
      "y" : 511
    },
    "isFadeOut" : true,
    "minX" : 3877,
    "maxX" : 3988,
    "minY" : 379,
    "maxY" : 526,
    "prop" : {
      "x" : 3877,
      "y" : 496,
      "width" : 54,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3888,
      "y" : 500
    },
    "connectors" : [ {
      "edgeId" : 3072,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3913,
          "y" : 493
        },
        "to" : {
          "x" : 3988,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 3944,
            "y" : 430
          },
          "b" : {
            "x" : 3956,
            "y" : 442
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3950,
            "y" : 436
          }
        }
      }
    }, {
      "edgeId" : 3078,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3906,
          "y" : 493
        },
        "to" : {
          "x" : 3916,
          "y" : 450
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 3905,
            "y" : 465
          },
          "b" : {
            "x" : 3917,
            "y" : 477
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3911,
            "y" : 471
          }
        }
      }
    } ]
  }, {
    "id" : 3082,
    "reactomeId" : 5675199,
    "displayName" : "hyperphosphorylated BRAF",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4199,
      "y" : 453
    },
    "isFadeOut" : true,
    "minX" : 3999,
    "maxX" : 4277,
    "minY" : 422,
    "maxY" : 478,
    "prop" : {
      "x" : 4128,
      "y" : 428,
      "width" : 143,
      "height" : 50
    },
    "innerProp" : {
      "x" : 4128,
      "y" : 434,
      "width" : 137,
      "height" : 44
    },
    "textPosition" : {
      "x" : 4127,
      "y" : 435
    },
    "nodeAttachments" : [ {
      "reactomeId" : 5672668,
      "label" : "P",
      "description" : "O-phospho-L-serine at 446",
      "shape" : {
        "a" : {
          "x" : 4138,
          "y" : 422
        },
        "b" : {
          "x" : 4150,
          "y" : 434
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4144,
          "y" : 428
        }
      }
    }, {
      "reactomeId" : 5672670,
      "label" : "P",
      "description" : "O-phospho-L-serine at 729",
      "shape" : {
        "a" : {
          "x" : 4154,
          "y" : 422
        },
        "b" : {
          "x" : 4166,
          "y" : 434
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4160,
          "y" : 428
        }
      }
    }, {
      "reactomeId" : 5672675,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 599",
      "shape" : {
        "a" : {
          "x" : 4170,
          "y" : 422
        },
        "b" : {
          "x" : 4182,
          "y" : 434
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4176,
          "y" : 428
        }
      }
    }, {
      "reactomeId" : 5672677,
      "label" : "P",
      "description" : "O-phospho-L-serine at 602",
      "shape" : {
        "a" : {
          "x" : 4186,
          "y" : 422
        },
        "b" : {
          "x" : 4198,
          "y" : 434
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4192,
          "y" : 428
        }
      }
    }, {
      "reactomeId" : 5675176,
      "label" : "P",
      "description" : "O-phospho-L-serine at 151",
      "shape" : {
        "a" : {
          "x" : 4202,
          "y" : 422
        },
        "b" : {
          "x" : 4214,
          "y" : 434
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4208,
          "y" : 428
        }
      }
    }, {
      "reactomeId" : 5675188,
      "label" : "P",
      "description" : "O-phospho-L-serine at 750",
      "shape" : {
        "a" : {
          "x" : 4218,
          "y" : 422
        },
        "b" : {
          "x" : 4230,
          "y" : 434
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4224,
          "y" : 428
        }
      }
    }, {
      "reactomeId" : 5675190,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 753",
      "shape" : {
        "a" : {
          "x" : 4234,
          "y" : 422
        },
        "b" : {
          "x" : 4246,
          "y" : 434
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4240,
          "y" : 428
        }
      }
    }, {
      "reactomeId" : 5675192,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 401",
      "shape" : {
        "a" : {
          "x" : 4265,
          "y" : 438
        },
        "b" : {
          "x" : 4277,
          "y" : 450
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 4271,
          "y" : 444
        }
      }
    } ],
    "connectors" : [ {
      "edgeId" : 3078,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4125,
          "y" : 451
        },
        "to" : {
          "x" : 3999,
          "y" : 448
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4118,
          "y" : 455
        },
        "b" : {
          "x" : 4125,
          "y" : 451
        },
        "c" : {
          "x" : 4118,
          "y" : 447
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4118,
          "y" : 447
        }
      }
    } ]
  }, {
    "id" : 3083,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4089,
      "y" : 512
    },
    "isFadeOut" : true,
    "minX" : 3999,
    "maxX" : 4116,
    "minY" : 379,
    "maxY" : 527,
    "prop" : {
      "x" : 4062,
      "y" : 497,
      "width" : 54,
      "height" : 30
    },
    "textPosition" : {
      "x" : 4072,
      "y" : 501
    },
    "connectors" : [ {
      "edgeId" : 3072,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4084,
          "y" : 494
        },
        "to" : {
          "x" : 4051,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 4061,
            "y" : 430
          },
          "b" : {
            "x" : 4073,
            "y" : 442
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 4067,
            "y" : 436
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 4078,
          "y" : 488
        },
        "b" : {
          "x" : 4084,
          "y" : 494
        },
        "c" : {
          "x" : 4086,
          "y" : 486
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4086,
          "y" : 486
        }
      }
    }, {
      "edgeId" : 3078,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4067,
          "y" : 494
        },
        "to" : {
          "x" : 3999,
          "y" : 448
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 4027,
            "y" : 465
          },
          "b" : {
            "x" : 4039,
            "y" : 477
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 4033,
            "y" : 471
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 4059,
          "y" : 493
        },
        "b" : {
          "x" : 4067,
          "y" : 494
        },
        "c" : {
          "x" : 4064,
          "y" : 487
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4064,
          "y" : 487
        }
      }
    } ]
  }, {
    "id" : 3346,
    "reactomeId" : 5675365,
    "displayName" : "cytosolic MAPK DUSPs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 4208,
      "y" : 762
    },
    "isFadeOut" : true,
    "minX" : 4077,
    "maxX" : 4263,
    "minY" : 718,
    "maxY" : 790,
    "prop" : {
      "x" : 4154,
      "y" : 735,
      "width" : 109,
      "height" : 55
    },
    "textPosition" : {
      "x" : 4157,
      "y" : 745
    },
    "connectors" : [ {
      "edgeId" : 3344,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4148,
          "y" : 744
        },
        "to" : {
          "x" : 4085,
          "y" : 723
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 4081,
          "y" : 722
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4081,
          "y" : 722
        }
      }
    } ]
  }, {
    "id" : 3351,
    "reactomeId" : 5675368,
    "displayName" : "nuclear MAPK DUSPs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 4115,
      "y" : 1209
    },
    "isFadeOut" : true,
    "minX" : 4064,
    "maxX" : 4166,
    "minY" : 1150,
    "maxY" : 1232,
    "prop" : {
      "x" : 4064,
      "y" : 1187,
      "width" : 102,
      "height" : 45
    },
    "textPosition" : {
      "x" : 4067,
      "y" : 1192
    },
    "connectors" : [ {
      "edgeId" : 3349,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4114,
          "y" : 1181
        },
        "to" : {
          "x" : 4113,
          "y" : 1158
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 4113,
          "y" : 1154
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4113,
          "y" : 1154
        }
      }
    } ]
  }, {
    "id" : 2842,
    "reactomeId" : 5672944,
    "displayName" : "PHB",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1397,
      "y" : 516
    },
    "isFadeOut" : true,
    "minX" : 1370,
    "maxX" : 1424,
    "minY" : 385,
    "maxY" : 529,
    "prop" : {
      "x" : 1370,
      "y" : 503,
      "width" : 54,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1380,
      "y" : 505
    },
    "connectors" : [ {
      "edgeId" : 357,
      "type" : "ACTIVATOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1397,
          "y" : 500
        },
        "to" : {
          "x" : 1398,
          "y" : 385
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1402,
          "y" : 392
        },
        "b" : {
          "x" : 1398,
          "y" : 385
        },
        "c" : {
          "x" : 1394,
          "y" : 392
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1394,
          "y" : 392
        }
      }
    } ]
  }, {
    "id" : 3355,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4072,
      "y" : 1087
    },
    "isFadeOut" : true,
    "minX" : 4045,
    "maxX" : 4099,
    "minY" : 1072,
    "maxY" : 1138,
    "prop" : {
      "x" : 4045,
      "y" : 1072,
      "width" : 54,
      "height" : 30
    },
    "textPosition" : {
      "x" : 4055,
      "y" : 1076
    },
    "connectors" : [ {
      "edgeId" : 3349,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4078,
          "y" : 1105
        },
        "to" : {
          "x" : 4093,
          "y" : 1138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3356,
    "reactomeId" : 113550,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4178,
      "y" : 1088
    },
    "isFadeOut" : true,
    "minX" : 4145,
    "maxX" : 4202,
    "minY" : 1075,
    "maxY" : 1140,
    "prop" : {
      "x" : 4155,
      "y" : 1075,
      "width" : 47,
      "height" : 26
    },
    "textPosition" : {
      "x" : 4169,
      "y" : 1077
    },
    "connectors" : [ {
      "edgeId" : 3349,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4169,
          "y" : 1104
        },
        "to" : {
          "x" : 4145,
          "y" : 1140
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4168,
          "y" : 1112
        },
        "b" : {
          "x" : 4169,
          "y" : 1104
        },
        "c" : {
          "x" : 4162,
          "y" : 1108
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4162,
          "y" : 1108
        }
      }
    } ]
  }, {
    "id" : 3358,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4056,
      "y" : 794
    },
    "isFadeOut" : true,
    "minX" : 4030,
    "maxX" : 4082,
    "minY" : 758,
    "maxY" : 810,
    "prop" : {
      "x" : 4030,
      "y" : 779,
      "width" : 52,
      "height" : 31
    },
    "textPosition" : {
      "x" : 4039,
      "y" : 784
    },
    "connectors" : [ {
      "edgeId" : 3344,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4048,
          "y" : 776
        },
        "to" : {
          "x" : 4038,
          "y" : 758
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3359,
    "reactomeId" : 5675361,
    "displayName" : "MAPK monomers and dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 4201,
      "y" : 591
    },
    "isFadeOut" : true,
    "minX" : 4135,
    "maxX" : 4256,
    "minY" : 565,
    "maxY" : 656,
    "prop" : {
      "x" : 4146,
      "y" : 565,
      "width" : 110,
      "height" : 53
    },
    "textPosition" : {
      "x" : 4148,
      "y" : 567
    },
    "connectors" : [ {
      "edgeId" : 3344,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4174,
          "y" : 624
        },
        "to" : {
          "x" : 4135,
          "y" : 656
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4171,
          "y" : 631
        },
        "b" : {
          "x" : 4174,
          "y" : 624
        },
        "c" : {
          "x" : 4166,
          "y" : 625
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4166,
          "y" : 625
        }
      }
    } ]
  }, {
    "id" : 3103,
    "reactomeId" : 5675204,
    "displayName" : "PEA15",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4077,
      "y" : 868
    },
    "isFadeOut" : true,
    "minX" : 4041,
    "maxX" : 4113,
    "minY" : 852,
    "maxY" : 911,
    "prop" : {
      "x" : 4041,
      "y" : 852,
      "width" : 72,
      "height" : 32
    },
    "textPosition" : {
      "x" : 4053,
      "y" : 857
    },
    "connectors" : [ {
      "edgeId" : 3102,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4088,
          "y" : 887
        },
        "to" : {
          "x" : 4108,
          "y" : 911
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3104,
    "reactomeId" : 5675205,
    "displayName" : "p-T,Y MAPK monomers and dimers:PEA15",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4241,
      "y" : 915
    },
    "isFadeOut" : true,
    "minX" : 4012,
    "maxX" : 4300,
    "minY" : 885,
    "maxY" : 1037,
    "prop" : {
      "x" : 4182,
      "y" : 885,
      "width" : 118,
      "height" : 60
    },
    "textPosition" : {
      "x" : 4188,
      "y" : 896
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 3102,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 3003,
      "type" : "INHIBITOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4183,
          "y" : 948
        },
        "to" : {
          "x" : 4014,
          "y" : 1033
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4012,
          "y" : 1029
        },
        "b" : {
          "x" : 4016,
          "y" : 1037
        },
        "c" : {
          "x" : 4014,
          "y" : 1033
        },
        "type" : "STOP",
        "centre" : {
          "x" : 4014,
          "y" : 1033
        }
      }
    } ]
  }, {
    "id" : 3364,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4212,
      "y" : 675
    },
    "isFadeOut" : true,
    "minX" : 4135,
    "maxX" : 4233,
    "minY" : 656,
    "maxY" : 690,
    "prop" : {
      "x" : 4191,
      "y" : 660,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 4202,
      "y" : 664
    },
    "connectors" : [ {
      "edgeId" : 3344,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4188,
          "y" : 669
        },
        "to" : {
          "x" : 4135,
          "y" : 656
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4180,
          "y" : 671
        },
        "b" : {
          "x" : 4188,
          "y" : 669
        },
        "c" : {
          "x" : 4182,
          "y" : 663
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4182,
          "y" : 663
        }
      }
    } ]
  }, {
    "id" : 3365,
    "reactomeId" : 5675363,
    "displayName" : "MAPK monomers and dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 4249,
      "y" : 1139
    },
    "isFadeOut" : true,
    "minX" : 4145,
    "maxX" : 4305,
    "minY" : 1114,
    "maxY" : 1164,
    "prop" : {
      "x" : 4193,
      "y" : 1114,
      "width" : 112,
      "height" : 50
    },
    "textPosition" : {
      "x" : 4192,
      "y" : 1121
    },
    "connectors" : [ {
      "edgeId" : 3349,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4187,
          "y" : 1139
        },
        "to" : {
          "x" : 4145,
          "y" : 1140
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4180,
          "y" : 1143
        },
        "b" : {
          "x" : 4187,
          "y" : 1139
        },
        "c" : {
          "x" : 4180,
          "y" : 1135
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4180,
          "y" : 1135
        }
      }
    } ]
  }, {
    "id" : 1061,
    "reactomeId" : 5672734,
    "displayName" : "RAF activating kinases",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2099,
      "y" : 537
    },
    "minX" : 2053,
    "maxX" : 2142,
    "minY" : 390,
    "maxY" : 560,
    "prop" : {
      "x" : 2056,
      "y" : 514,
      "width" : 86,
      "height" : 46
    },
    "textPosition" : {
      "x" : 2062,
      "y" : 513
    },
    "connectors" : [ {
      "edgeId" : 813,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2092,
          "y" : 508
        },
        "to" : {
          "x" : 2058,
          "y" : 398
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2057,
          "y" : 394
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2057,
          "y" : 394
        }
      }
    }, {
      "edgeId" : 165482,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2092,
          "y" : 508
        },
        "to" : {
          "x" : 2058,
          "y" : 398
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2057,
          "y" : 394
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2057,
          "y" : 394
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 4901,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3755,
      "y" : 704
    },
    "isFadeOut" : true,
    "minX" : 3733,
    "maxX" : 3778,
    "minY" : 643,
    "maxY" : 716,
    "prop" : {
      "x" : 3733,
      "y" : 693,
      "width" : 45,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3738,
      "y" : 694
    },
    "connectors" : [ {
      "edgeId" : 4900,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3757,
          "y" : 690
        },
        "to" : {
          "x" : 3769,
          "y" : 643
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3757,
            "y" : 660
          },
          "b" : {
            "x" : 3769,
            "y" : 672
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3763,
            "y" : 666
          }
        }
      }
    } ]
  }, {
    "id" : 4902,
    "reactomeId" : 9635774,
    "displayName" : "PTPN7:p-T-MAPK dimers",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3887,
      "y" : 593
    },
    "isFadeOut" : true,
    "minX" : 3826,
    "maxX" : 3949,
    "minY" : 576,
    "maxY" : 645,
    "prop" : {
      "x" : 3826,
      "y" : 576,
      "width" : 123,
      "height" : 35
    },
    "textPosition" : {
      "x" : 3831,
      "y" : 576
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 4900,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3868,
          "y" : 614
        },
        "to" : {
          "x" : 3832,
          "y" : 645
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3865,
          "y" : 622
        },
        "b" : {
          "x" : 3868,
          "y" : 614
        },
        "c" : {
          "x" : 3860,
          "y" : 615
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3860,
          "y" : 615
        }
      }
    } ]
  }, {
    "id" : 4904,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3843,
      "y" : 702
    },
    "isFadeOut" : true,
    "minX" : 3822,
    "maxX" : 3864,
    "minY" : 645,
    "maxY" : 717,
    "prop" : {
      "x" : 3822,
      "y" : 687,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3833,
      "y" : 691
    },
    "connectors" : [ {
      "edgeId" : 4900,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3840,
          "y" : 684
        },
        "to" : {
          "x" : 3832,
          "y" : 645
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3830,
            "y" : 658
          },
          "b" : {
            "x" : 3842,
            "y" : 670
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3836,
            "y" : 664
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 3835,
          "y" : 678
        },
        "b" : {
          "x" : 3840,
          "y" : 684
        },
        "c" : {
          "x" : 3843,
          "y" : 676
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3843,
          "y" : 676
        }
      }
    } ]
  }, {
    "id" : 306,
    "reactomeId" : 29438,
    "displayName" : "GTP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 528,
      "y" : 595
    },
    "isFadeOut" : true,
    "minX" : 403,
    "maxX" : 554,
    "minY" : 579,
    "maxY" : 655,
    "prop" : {
      "x" : 503,
      "y" : 579,
      "width" : 51,
      "height" : 32
    },
    "textPosition" : {
      "x" : 512,
      "y" : 584
    },
    "connectors" : [ {
      "edgeId" : 4907,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 505,
          "y" : 614
        },
        "to" : {
          "x" : 445,
          "y" : 655
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 305,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 500,
          "y" : 601
        },
        "to" : {
          "x" : 403,
          "y" : 628
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 819,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1925,
      "y" : 336
    },
    "minX" : 1906,
    "maxX" : 1981,
    "minY" : 320,
    "maxY" : 380,
    "prop" : {
      "x" : 1906,
      "y" : 321,
      "width" : 38,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1909,
      "y" : 325
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1939,
          "y" : 326
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1939,
          "y" : 326
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 813,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1947,
          "y" : 350
        },
        "to" : {
          "x" : 1981,
          "y" : 380
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1958,
            "y" : 359
          },
          "b" : {
            "x" : 1970,
            "y" : 371
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1964,
            "y" : 365
          }
        }
      }
    }, {
      "edgeId" : 165482,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1947,
          "y" : 350
        },
        "to" : {
          "x" : 1981,
          "y" : 380
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1958,
            "y" : 359
          },
          "b" : {
            "x" : 1970,
            "y" : 371
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1964,
            "y" : 365
          }
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 307,
    "reactomeId" : 109796,
    "displayName" : "p21 RAS:GDP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 405,
      "y" : 733
    },
    "isFadeOut" : true,
    "minX" : 368,
    "maxX" : 476,
    "minY" : 628,
    "maxY" : 759,
    "prop" : {
      "x" : 368,
      "y" : 714,
      "width" : 74,
      "height" : 39
    },
    "textPosition" : {
      "x" : 373,
      "y" : 718
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 4905,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 4907,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 415,
          "y" : 711
        },
        "to" : {
          "x" : 445,
          "y" : 655
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 305,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 404,
          "y" : 711
        },
        "to" : {
          "x" : 403,
          "y" : 628
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 316,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 445,
          "y" : 746
        },
        "to" : {
          "x" : 476,
          "y" : 759
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 453,
          "y" : 745
        },
        "b" : {
          "x" : 445,
          "y" : 746
        },
        "c" : {
          "x" : 450,
          "y" : 752
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 450,
          "y" : 752
        }
      }
    } ]
  }, {
    "id" : 820,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2116,
      "y" : 311
    },
    "minX" : 2078,
    "maxX" : 2137,
    "minY" : 295,
    "maxY" : 381,
    "prop" : {
      "x" : 2096,
      "y" : 296,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2099,
      "y" : 300
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2131,
          "y" : 301
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2131,
          "y" : 301
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 813,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2107,
          "y" : 329
        },
        "to" : {
          "x" : 2078,
          "y" : 381
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 2086,
            "y" : 349
          },
          "b" : {
            "x" : 2098,
            "y" : 361
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2092,
            "y" : 355
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2107,
          "y" : 337
        },
        "b" : {
          "x" : 2107,
          "y" : 329
        },
        "c" : {
          "x" : 2100,
          "y" : 333
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2100,
          "y" : 333
        }
      }
    }, {
      "edgeId" : 165482,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2107,
          "y" : 329
        },
        "to" : {
          "x" : 2078,
          "y" : 381
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 2086,
            "y" : 349
          },
          "b" : {
            "x" : 2098,
            "y" : 361
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2092,
            "y" : 355
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2107,
          "y" : 337
        },
        "b" : {
          "x" : 2107,
          "y" : 329
        },
        "c" : {
          "x" : 2100,
          "y" : 333
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2100,
          "y" : 333
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 308,
    "reactomeId" : 109783,
    "displayName" : "p21 RAS:GTP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 581,
      "y" : 374
    },
    "isFadeOut" : true,
    "minX" : 416,
    "maxX" : 1348,
    "minY" : 355,
    "maxY" : 717,
    "prop" : {
      "x" : 543,
      "y" : 355,
      "width" : 76,
      "height" : 38
    },
    "textPosition" : {
      "x" : 549,
      "y" : 358
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 4905,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 4905,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 581,
          "y" : 396
        },
        "to" : {
          "x" : 581,
          "y" : 601
        }
      }, {
        "from" : {
          "x" : 581,
          "y" : 601
        },
        "to" : {
          "x" : 562,
          "y" : 627
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 560,
          "y" : 630
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 560,
          "y" : 630
        }
      }
    }, {
      "edgeId" : 6315,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 612,
          "y" : 396
        },
        "to" : {
          "x" : 638,
          "y" : 408
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 4907,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 566,
          "y" : 396
        },
        "to" : {
          "x" : 461,
          "y" : 531
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 565,
          "y" : 404
        },
        "b" : {
          "x" : 566,
          "y" : 396
        },
        "c" : {
          "x" : 559,
          "y" : 399
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 559,
          "y" : 399
        }
      }
    }, {
      "edgeId" : 305,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 548,
          "y" : 396
        },
        "to" : {
          "x" : 416,
          "y" : 470
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 544,
          "y" : 403
        },
        "b" : {
          "x" : 548,
          "y" : 396
        },
        "c" : {
          "x" : 540,
          "y" : 396
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 540,
          "y" : 396
        }
      }
    }, {
      "edgeId" : 313,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 583,
          "y" : 396
        },
        "to" : {
          "x" : 630,
          "y" : 717
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2273,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 622,
          "y" : 380
        },
        "to" : {
          "x" : 795,
          "y" : 409
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 357,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 622,
          "y" : 374
        },
        "to" : {
          "x" : 1348,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 309,
    "reactomeId" : 29420,
    "displayName" : "GDP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 528,
      "y" : 511
    },
    "isFadeOut" : true,
    "minX" : 416,
    "maxX" : 554,
    "minY" : 470,
    "maxY" : 531,
    "prop" : {
      "x" : 502,
      "y" : 496,
      "width" : 52,
      "height" : 31
    },
    "textPosition" : {
      "x" : 511,
      "y" : 501
    },
    "connectors" : [ {
      "edgeId" : 4907,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 499,
          "y" : 518
        },
        "to" : {
          "x" : 461,
          "y" : 531
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 494,
          "y" : 524
        },
        "b" : {
          "x" : 499,
          "y" : 518
        },
        "c" : {
          "x" : 491,
          "y" : 516
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 491,
          "y" : 516
        }
      }
    }, {
      "edgeId" : 305,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 499,
          "y" : 501
        },
        "to" : {
          "x" : 416,
          "y" : 470
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 491,
          "y" : 502
        },
        "b" : {
          "x" : 499,
          "y" : 501
        },
        "c" : {
          "x" : 494,
          "y" : 495
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 494,
          "y" : 495
        }
      }
    } ]
  }, {
    "id" : 2870,
    "reactomeId" : 5674133,
    "displayName" : "WDR83:LAMTOR2:LAMTOR3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2509,
      "y" : 1009
    },
    "isFadeOut" : true,
    "minX" : 2449,
    "maxX" : 2621,
    "minY" : 987,
    "maxY" : 1031,
    "prop" : {
      "x" : 2449,
      "y" : 987,
      "width" : 121,
      "height" : 44
    },
    "textPosition" : {
      "x" : 2451,
      "y" : 996
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2869,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2573,
          "y" : 1007
        },
        "to" : {
          "x" : 2621,
          "y" : 1006
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 310,
    "reactomeId" : 5672601,
    "displayName" : "RAS GEFs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 286,
      "y" : 593
    },
    "isFadeOut" : true,
    "minX" : 246,
    "maxX" : 401,
    "minY" : 537,
    "maxY" : 613,
    "prop" : {
      "x" : 246,
      "y" : 573,
      "width" : 81,
      "height" : 40
    },
    "textPosition" : {
      "x" : 253,
      "y" : 582
    },
    "connectors" : [ {
      "edgeId" : 305,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 318,
          "y" : 567
        },
        "to" : {
          "x" : 376,
          "y" : 537
        }
      }, {
        "from" : {
          "x" : 376,
          "y" : 537
        },
        "to" : {
          "x" : 393,
          "y" : 541
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 397,
          "y" : 542
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 397,
          "y" : 542
        }
      }
    } ]
  }, {
    "id" : 1079,
    "reactomeId" : 5672710,
    "displayName" : "'activator' RAF:YWHAB dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1286,
      "y" : 512
    },
    "isFadeOut" : true,
    "minX" : 1223,
    "maxX" : 1350,
    "minY" : 379,
    "maxY" : 539,
    "prop" : {
      "x" : 1223,
      "y" : 485,
      "width" : 127,
      "height" : 54
    },
    "textPosition" : {
      "x" : 1236,
      "y" : 504
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 357,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1298,
          "y" : 482
        },
        "to" : {
          "x" : 1348,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2871,
    "reactomeId" : 5674136,
    "displayName" : "activated RAF homo/heterodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2660,
      "y" : 911
    },
    "isFadeOut" : true,
    "minX" : 2598,
    "maxX" : 2723,
    "minY" : 893,
    "maxY" : 1006,
    "prop" : {
      "x" : 2598,
      "y" : 893,
      "width" : 125,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2598,
      "y" : 894
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2869,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2652,
          "y" : 932
        },
        "to" : {
          "x" : 2621,
          "y" : 1006
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1081,
    "reactomeId" : 5672707,
    "displayName" : "inactive RAFs:YWHAB dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1089,
      "y" : 632
    },
    "isFadeOut" : true,
    "minX" : 1030,
    "maxX" : 1170,
    "minY" : 585,
    "maxY" : 656,
    "prop" : {
      "x" : 1030,
      "y" : 609,
      "width" : 118,
      "height" : 47
    },
    "textPosition" : {
      "x" : 1042,
      "y" : 621
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 204
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 6289,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1116,
          "y" : 606
        },
        "to" : {
          "x" : 1143,
          "y" : 585
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 351,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1151,
          "y" : 637
        },
        "to" : {
          "x" : 1170,
          "y" : 639
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 364,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 314,
    "reactomeId" : 5658216,
    "displayName" : "RAS GAPs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 573,
      "y" : 685
    },
    "isFadeOut" : true,
    "minX" : 476,
    "maxX" : 630,
    "minY" : 671,
    "maxY" : 759,
    "prop" : {
      "x" : 537,
      "y" : 671,
      "width" : 72,
      "height" : 28
    },
    "textPosition" : {
      "x" : 539,
      "y" : 674
    },
    "connectors" : [ {
      "edgeId" : 313,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 597,
          "y" : 705
        },
        "to" : {
          "x" : 630,
          "y" : 717
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 316,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 561,
          "y" : 705
        },
        "to" : {
          "x" : 513,
          "y" : 757
        }
      }, {
        "from" : {
          "x" : 513,
          "y" : 757
        },
        "to" : {
          "x" : 476,
          "y" : 759
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 559,
          "y" : 713
        },
        "b" : {
          "x" : 561,
          "y" : 705
        },
        "c" : {
          "x" : 553,
          "y" : 707
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 553,
          "y" : 707
        }
      }
    } ]
  }, {
    "id" : 2874,
    "reactomeId" : 5674138,
    "displayName" : "WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2726,
      "y" : 1001
    },
    "isFadeOut" : true,
    "minX" : 2663,
    "maxX" : 2822,
    "minY" : 969,
    "maxY" : 1033,
    "prop" : {
      "x" : 2663,
      "y" : 969,
      "width" : 126,
      "height" : 64
    },
    "textPosition" : {
      "x" : 2661,
      "y" : 970
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2869,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2883,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2792,
          "y" : 1002
        },
        "to" : {
          "x" : 2822,
          "y" : 1003
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 315,
    "reactomeId" : 5658227,
    "displayName" : "p21 RAS:GTP:RAS GAPs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 516,
      "y" : 880
    },
    "isFadeOut" : true,
    "minX" : 468,
    "maxX" : 564,
    "minY" : 790,
    "maxY" : 903,
    "prop" : {
      "x" : 468,
      "y" : 858,
      "width" : 96,
      "height" : 45
    },
    "textPosition" : {
      "x" : 470,
      "y" : 868
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 313,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 316,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 316,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 528,
          "y" : 855
        },
        "to" : {
          "x" : 564,
          "y" : 792
        }
      }, {
        "from" : {
          "x" : 564,
          "y" : 792
        },
        "to" : {
          "x" : 503,
          "y" : 794
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 499,
          "y" : 794
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 499,
          "y" : 794
        }
      }
    } ]
  }, {
    "id" : 317,
    "reactomeId" : 5658232,
    "displayName" : "SPRED dimer:NF1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 614,
      "y" : 964
    },
    "isFadeOut" : true,
    "minX" : 568,
    "maxX" : 661,
    "minY" : 942,
    "maxY" : 1018,
    "prop" : {
      "x" : 568,
      "y" : 942,
      "width" : 93,
      "height" : 44
    },
    "textPosition" : {
      "x" : 568,
      "y" : 951
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 318,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 322,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 614,
          "y" : 989
        },
        "to" : {
          "x" : 614,
          "y" : 1018
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1085,
    "reactomeId" : 5672728,
    "displayName" : "dephosphorylated inactive RAFS:YWHAB dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1354,
      "y" : 638
    },
    "isFadeOut" : true,
    "minX" : 1222,
    "maxX" : 1429,
    "minY" : 585,
    "maxY" : 669,
    "prop" : {
      "x" : 1280,
      "y" : 608,
      "width" : 149,
      "height" : 61
    },
    "textPosition" : {
      "x" : 1283,
      "y" : 620
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 204
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 6289,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1280,
          "y" : 605
        },
        "to" : {
          "x" : 1227,
          "y" : 585
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1272,
          "y" : 606
        },
        "b" : {
          "x" : 1280,
          "y" : 605
        },
        "c" : {
          "x" : 1275,
          "y" : 599
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1275,
          "y" : 599
        }
      }
    }, {
      "edgeId" : 2227,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 351,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1277,
          "y" : 637
        },
        "to" : {
          "x" : 1222,
          "y" : 637
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1270,
          "y" : 641
        },
        "b" : {
          "x" : 1277,
          "y" : 637
        },
        "c" : {
          "x" : 1270,
          "y" : 633
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1270,
          "y" : 633
        }
      }
    } ]
  }, {
    "id" : 319,
    "reactomeId" : 5658219,
    "displayName" : "SPRED dimer",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 768,
      "y" : 930
    },
    "isFadeOut" : true,
    "minX" : 703,
    "maxX" : 813,
    "minY" : 908,
    "maxY" : 941,
    "prop" : {
      "x" : 724,
      "y" : 919,
      "width" : 89,
      "height" : 22
    },
    "textPosition" : {
      "x" : 724,
      "y" : 919
    },
    "connectors" : [ {
      "edgeId" : 318,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 735,
          "y" : 913
        },
        "to" : {
          "x" : 703,
          "y" : 908
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 326,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 320,
    "reactomeId" : 947770,
    "displayName" : "NF1(2-2839)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 695,
      "y" : 872
    },
    "isFadeOut" : true,
    "minX" : 652,
    "maxX" : 739,
    "minY" : 861,
    "maxY" : 908,
    "prop" : {
      "x" : 652,
      "y" : 861,
      "width" : 87,
      "height" : 22
    },
    "textPosition" : {
      "x" : 652,
      "y" : 861
    },
    "connectors" : [ {
      "edgeId" : 318,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 697,
          "y" : 886
        },
        "to" : {
          "x" : 703,
          "y" : 908
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4162,
    "reactomeId" : 171021,
    "displayName" : "p-T183,Y185-MAPK12",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2921,
      "y" : 1409
    },
    "isFadeOut" : true,
    "minX" : 2864,
    "maxX" : 3040,
    "minY" : 1383,
    "maxY" : 1441,
    "prop" : {
      "x" : 2870,
      "y" : 1383,
      "width" : 102,
      "height" : 52
    },
    "innerProp" : {
      "x" : 2876,
      "y" : 1383,
      "width" : 96,
      "height" : 46
    },
    "textPosition" : {
      "x" : 2876,
      "y" : 1391
    },
    "nodeAttachments" : [ {
      "reactomeId" : 3006596,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 183",
      "shape" : {
        "a" : {
          "x" : 2880,
          "y" : 1429
        },
        "b" : {
          "x" : 2892,
          "y" : 1441
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 2886,
          "y" : 1435
        }
      }
    }, {
      "reactomeId" : 3006594,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 185",
      "shape" : {
        "a" : {
          "x" : 2864,
          "y" : 1422
        },
        "b" : {
          "x" : 2876,
          "y" : 1434
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 2870,
          "y" : 1428
        }
      }
    } ],
    "connectors" : [ {
      "edgeId" : 4161,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2975,
          "y" : 1409
        },
        "to" : {
          "x" : 3040,
          "y" : 1409
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 323,
    "reactomeId" : 113595,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 679,
      "y" : 1021
    },
    "isFadeOut" : true,
    "minX" : 614,
    "maxX" : 699,
    "minY" : 1005,
    "maxY" : 1038,
    "prop" : {
      "x" : 660,
      "y" : 1005,
      "width" : 39,
      "height" : 33
    },
    "textPosition" : {
      "x" : 667,
      "y" : 1011
    },
    "connectors" : [ {
      "edgeId" : 322,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 654,
          "y" : 1020
        },
        "to" : {
          "x" : 614,
          "y" : 1018
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4163,
    "reactomeId" : 8867650,
    "displayName" : "PTPN3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3013,
      "y" : 1311
    },
    "isFadeOut" : true,
    "minX" : 2989,
    "maxX" : 3364,
    "minY" : 1300,
    "maxY" : 1409,
    "prop" : {
      "x" : 2989,
      "y" : 1300,
      "width" : 48,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2989,
      "y" : 1300
    },
    "connectors" : [ {
      "edgeId" : 4161,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3016,
          "y" : 1325
        },
        "to" : {
          "x" : 3040,
          "y" : 1409
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 4165,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3040,
          "y" : 1310
        },
        "to" : {
          "x" : 3319,
          "y" : 1308
        }
      }, {
        "from" : {
          "x" : 3319,
          "y" : 1308
        },
        "to" : {
          "x" : 3364,
          "y" : 1405
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3047,
          "y" : 1306
        },
        "b" : {
          "x" : 3040,
          "y" : 1310
        },
        "c" : {
          "x" : 3047,
          "y" : 1314
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3047,
          "y" : 1314
        }
      }
    } ]
  }, {
    "id" : 324,
    "reactomeId" : 5658420,
    "displayName" : "SPRED dimer:ub-NF1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 610,
      "y" : 1108
    },
    "isFadeOut" : true,
    "minX" : 555,
    "maxX" : 665,
    "minY" : 1090,
    "maxY" : 1126,
    "prop" : {
      "x" : 555,
      "y" : 1090,
      "width" : 110,
      "height" : 36
    },
    "textPosition" : {
      "x" : 564,
      "y" : 1091
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 322,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 326,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2884,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2815,
      "y" : 941
    },
    "isFadeOut" : true,
    "minX" : 2795,
    "maxX" : 2835,
    "minY" : 926,
    "maxY" : 1003,
    "prop" : {
      "x" : 2795,
      "y" : 926,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2799,
      "y" : 930
    },
    "connectors" : [ {
      "edgeId" : 2883,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2816,
          "y" : 959
        },
        "to" : {
          "x" : 2822,
          "y" : 1003
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 2813,
            "y" : 975
          },
          "b" : {
            "x" : 2825,
            "y" : 987
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2819,
            "y" : 981
          }
        }
      }
    } ]
  }, {
    "id" : 4164,
    "reactomeId" : 8867651,
    "displayName" : "PTPN3:p-T183,Y185-MAPK12",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3181,
      "y" : 1407
    },
    "isFadeOut" : true,
    "minX" : 3130,
    "maxX" : 3322,
    "minY" : 1389,
    "maxY" : 1497,
    "prop" : {
      "x" : 3130,
      "y" : 1389,
      "width" : 103,
      "height" : 36
    },
    "textPosition" : {
      "x" : 3132,
      "y" : 1390
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 4161,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 4165,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3236,
          "y" : 1405
        },
        "to" : {
          "x" : 3291,
          "y" : 1404
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 4165,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3236,
          "y" : 1421
        },
        "to" : {
          "x" : 3301,
          "y" : 1440
        }
      }, {
        "from" : {
          "x" : 3301,
          "y" : 1440
        },
        "to" : {
          "x" : 3316,
          "y" : 1418
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3318,
          "y" : 1415
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3318,
          "y" : 1415
        }
      }
    }, {
      "edgeId" : 4170,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3185,
          "y" : 1428
        },
        "to" : {
          "x" : 3205,
          "y" : 1497
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 4170,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3213,
          "y" : 1428
        },
        "to" : {
          "x" : 3264,
          "y" : 1453
        }
      }, {
        "from" : {
          "x" : 3264,
          "y" : 1453
        },
        "to" : {
          "x" : 3259,
          "y" : 1485
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3258,
          "y" : 1489
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3258,
          "y" : 1489
        }
      }
    } ]
  }, {
    "id" : 325,
    "reactomeId" : 5658416,
    "displayName" : "KBTBD7:CUL3:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 528,
      "y" : 1048
    },
    "isFadeOut" : true,
    "minX" : 486,
    "maxX" : 598,
    "minY" : 1031,
    "maxY" : 1066,
    "prop" : {
      "x" : 486,
      "y" : 1031,
      "width" : 85,
      "height" : 35
    },
    "textPosition" : {
      "x" : 491,
      "y" : 1031
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 322,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 574,
          "y" : 1043
        },
        "to" : {
          "x" : 590,
          "y" : 1041
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 594,
          "y" : 1041
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 594,
          "y" : 1041
        }
      }
    } ]
  }, {
    "id" : 2885,
    "reactomeId" : 5674131,
    "displayName" : "WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2977,
      "y" : 999
    },
    "isFadeOut" : true,
    "minX" : 2880,
    "maxX" : 3041,
    "minY" : 967,
    "maxY" : 1031,
    "prop" : {
      "x" : 2913,
      "y" : 967,
      "width" : 128,
      "height" : 64
    },
    "textPosition" : {
      "x" : 2912,
      "y" : 968
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2883,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2910,
          "y" : 1001
        },
        "to" : {
          "x" : 2880,
          "y" : 1003
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2903,
          "y" : 1005
        },
        "b" : {
          "x" : 2910,
          "y" : 1001
        },
        "c" : {
          "x" : 2903,
          "y" : 997
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2903,
          "y" : 997
        }
      }
    } ]
  }, {
    "id" : 4166,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3247,
      "y" : 1343
    },
    "isFadeOut" : true,
    "minX" : 3220,
    "maxX" : 3291,
    "minY" : 1327,
    "maxY" : 1404,
    "prop" : {
      "x" : 3220,
      "y" : 1327,
      "width" : 54,
      "height" : 33
    },
    "textPosition" : {
      "x" : 3230,
      "y" : 1333
    },
    "connectors" : [ {
      "edgeId" : 4165,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3258,
          "y" : 1363
        },
        "to" : {
          "x" : 3291,
          "y" : 1404
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3268,
            "y" : 1377
          },
          "b" : {
            "x" : 3280,
            "y" : 1389
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3274,
            "y" : 1383
          }
        }
      }
    } ]
  }, {
    "id" : 2886,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2896,
      "y" : 939
    },
    "isFadeOut" : true,
    "minX" : 2876,
    "maxX" : 2917,
    "minY" : 924,
    "maxY" : 1003,
    "prop" : {
      "x" : 2876,
      "y" : 924,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2880,
      "y" : 928
    },
    "connectors" : [ {
      "edgeId" : 2883,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2892,
          "y" : 957
        },
        "to" : {
          "x" : 2880,
          "y" : 1003
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 2880,
            "y" : 974
          },
          "b" : {
            "x" : 2892,
            "y" : 986
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2886,
            "y" : 980
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2894,
          "y" : 965
        },
        "b" : {
          "x" : 2892,
          "y" : 957
        },
        "c" : {
          "x" : 2886,
          "y" : 963
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2886,
          "y" : 963
        }
      }
    } ]
  }, {
    "id" : 4167,
    "reactomeId" : 171025,
    "displayName" : "MAPK12",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3466,
      "y" : 1395
    },
    "isFadeOut" : true,
    "minX" : 3364,
    "maxX" : 3509,
    "minY" : 1376,
    "maxY" : 1415,
    "prop" : {
      "x" : 3424,
      "y" : 1376,
      "width" : 85,
      "height" : 39
    },
    "textPosition" : {
      "x" : 3438,
      "y" : 1385
    },
    "connectors" : [ {
      "edgeId" : 4165,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3421,
          "y" : 1399
        },
        "to" : {
          "x" : 3364,
          "y" : 1405
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3415,
          "y" : 1404
        },
        "b" : {
          "x" : 3421,
          "y" : 1399
        },
        "c" : {
          "x" : 3414,
          "y" : 1396
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3414,
          "y" : 1396
        }
      }
    } ]
  }, {
    "id" : 327,
    "reactomeId" : 68819,
    "displayName" : "26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 711,
      "y" : 1175
    },
    "isFadeOut" : true,
    "minX" : 668,
    "maxX" : 754,
    "minY" : 1097,
    "maxY" : 1195,
    "prop" : {
      "x" : 668,
      "y" : 1155,
      "width" : 86,
      "height" : 40
    },
    "textPosition" : {
      "x" : 669,
      "y" : 1160
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 326,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 712,
          "y" : 1152
        },
        "to" : {
          "x" : 715,
          "y" : 1105
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 715,
          "y" : 1101
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 715,
          "y" : 1101
        }
      }
    } ]
  }, {
    "id" : 4169,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3406,
      "y" : 1330
    },
    "isFadeOut" : true,
    "minX" : 3364,
    "maxX" : 3427,
    "minY" : 1315,
    "maxY" : 1405,
    "prop" : {
      "x" : 3385,
      "y" : 1315,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3396,
      "y" : 1319
    },
    "connectors" : [ {
      "edgeId" : 4165,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3397,
          "y" : 1348
        },
        "to" : {
          "x" : 3364,
          "y" : 1405
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3374,
            "y" : 1370
          },
          "b" : {
            "x" : 3386,
            "y" : 1382
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3380,
            "y" : 1376
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 3397,
          "y" : 1356
        },
        "b" : {
          "x" : 3397,
          "y" : 1348
        },
        "c" : {
          "x" : 3390,
          "y" : 1352
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3390,
          "y" : 1352
        }
      }
    } ]
  }, {
    "id" : 4171,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3166,
      "y" : 1543
    },
    "isFadeOut" : true,
    "minX" : 3146,
    "maxX" : 3205,
    "minY" : 1497,
    "maxY" : 1558,
    "prop" : {
      "x" : 3146,
      "y" : 1528,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3150,
      "y" : 1532
    },
    "connectors" : [ {
      "edgeId" : 4170,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3178,
          "y" : 1525
        },
        "to" : {
          "x" : 3205,
          "y" : 1497
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4172,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3327,
      "y" : 1550
    },
    "isFadeOut" : true,
    "minX" : 3293,
    "maxX" : 3348,
    "minY" : 1504,
    "maxY" : 1565,
    "prop" : {
      "x" : 3307,
      "y" : 1535,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3311,
      "y" : 1539
    },
    "connectors" : [ {
      "edgeId" : 4170,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3315,
          "y" : 1532
        },
        "to" : {
          "x" : 3293,
          "y" : 1504
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3308,
          "y" : 1529
        },
        "b" : {
          "x" : 3315,
          "y" : 1532
        },
        "c" : {
          "x" : 3314,
          "y" : 1524
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3314,
          "y" : 1524
        }
      }
    } ]
  }, {
    "id" : 4173,
    "reactomeId" : 8868113,
    "displayName" : "p-S459 PTPN3:p-T183,Y185-MAPK12",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3454,
      "y" : 1504
    },
    "isFadeOut" : true,
    "minX" : 3293,
    "maxX" : 3512,
    "minY" : 1479,
    "maxY" : 1529,
    "prop" : {
      "x" : 3396,
      "y" : 1479,
      "width" : 116,
      "height" : 50
    },
    "textPosition" : {
      "x" : 3398,
      "y" : 1480
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 4170,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3393,
          "y" : 1504
        },
        "to" : {
          "x" : 3293,
          "y" : 1504
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3386,
          "y" : 1508
        },
        "b" : {
          "x" : 3393,
          "y" : 1504
        },
        "c" : {
          "x" : 3386,
          "y" : 1500
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3386,
          "y" : 1500
        }
      }
    } ]
  }, {
    "id" : 5209,
    "reactomeId" : 9657587,
    "displayName" : "activated RAF:scaffold:p-2S  MAP2K:MAPK:single mechanism MAP2K inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2897,
      "y" : 405
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 2827,
    "maxX" : 2990,
    "minY" : 294,
    "maxY" : 445,
    "prop" : {
      "x" : 2827,
      "y" : 366,
      "width" : 140,
      "height" : 79
    },
    "textPosition" : {
      "x" : 2831,
      "y" : 368
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 2253,
      "type" : "INHIBITOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2929,
          "y" : 363
        },
        "to" : {
          "x" : 2987,
          "y" : 297
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2984,
          "y" : 294
        },
        "b" : {
          "x" : 2990,
          "y" : 300
        },
        "c" : {
          "x" : 2987,
          "y" : 297
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2987,
          "y" : 297
        }
      }
    }, {
      "edgeId" : 5213,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    }, {
      "edgeId" : 165485,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2929,
          "y" : 363
        },
        "to" : {
          "x" : 2987,
          "y" : 297
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2984,
          "y" : 294
        },
        "b" : {
          "x" : 2990,
          "y" : 300
        },
        "c" : {
          "x" : 2987,
          "y" : 297
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2987,
          "y" : 297
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 5210,
    "reactomeId" : 9657583,
    "displayName" : "activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2693,
      "y" : 425
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 2629,
    "maxX" : 2987,
    "minY" : 290,
    "maxY" : 464,
    "prop" : {
      "x" : 2629,
      "y" : 386,
      "width" : 128,
      "height" : 78
    },
    "textPosition" : {
      "x" : 2628,
      "y" : 387
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 2209,
      "type" : "INHIBITOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2662,
          "y" : 383
        },
        "to" : {
          "x" : 2634,
          "y" : 349
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2631,
          "y" : 352
        },
        "b" : {
          "x" : 2637,
          "y" : 346
        },
        "c" : {
          "x" : 2634,
          "y" : 349
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2634,
          "y" : 349
        }
      }
    }, {
      "edgeId" : 2253,
      "type" : "INHIBITOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2760,
          "y" : 396
        },
        "to" : {
          "x" : 2985,
          "y" : 294
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2983,
          "y" : 290
        },
        "b" : {
          "x" : 2987,
          "y" : 298
        },
        "c" : {
          "x" : 2985,
          "y" : 294
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2985,
          "y" : 294
        }
      }
    }, {
      "edgeId" : 5211,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    }, {
      "edgeId" : 165485,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2760,
          "y" : 396
        },
        "to" : {
          "x" : 2985,
          "y" : 294
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2983,
          "y" : 290
        },
        "b" : {
          "x" : 2987,
          "y" : 298
        },
        "c" : {
          "x" : 2985,
          "y" : 294
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2985,
          "y" : 294
        }
      },
      "isDisease" : true
    }, {
      "edgeId" : 165490,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2662,
          "y" : 383
        },
        "to" : {
          "x" : 2634,
          "y" : 349
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2631,
          "y" : 352
        },
        "b" : {
          "x" : 2637,
          "y" : 346
        },
        "c" : {
          "x" : 2634,
          "y" : 349
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2634,
          "y" : 349
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 5212,
    "reactomeId" : 9657567,
    "displayName" : "dual mechanism MAP2K1/2 inhibitors",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2501,
      "y" : 504
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 2429,
    "maxX" : 2574,
    "minY" : 442,
    "maxY" : 527,
    "prop" : {
      "x" : 2429,
      "y" : 481,
      "width" : 145,
      "height" : 46
    },
    "textPosition" : {
      "x" : 2436,
      "y" : 486
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 5211,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2526,
          "y" : 475
        },
        "to" : {
          "x" : 2571,
          "y" : 442
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 5214,
    "reactomeId" : 9657574,
    "displayName" : "single mechanism MAP2K1/2 inhibitors",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2712,
      "y" : 505
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 2646,
    "maxX" : 2783,
    "minY" : 455,
    "maxY" : 530,
    "prop" : {
      "x" : 2646,
      "y" : 481,
      "width" : 133,
      "height" : 49
    },
    "textPosition" : {
      "x" : 2647,
      "y" : 488
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 5213,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2746,
          "y" : 475
        },
        "to" : {
          "x" : 2783,
          "y" : 455
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 2912,
    "reactomeId" : 5674103,
    "displayName" : "PAQR3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1538,
      "y" : 1437
    },
    "isFadeOut" : true,
    "minX" : 1514,
    "maxX" : 1563,
    "minY" : 1398,
    "maxY" : 1448,
    "prop" : {
      "x" : 1514,
      "y" : 1426,
      "width" : 49,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1514,
      "y" : 1426
    },
    "connectors" : [ {
      "edgeId" : 2911,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1538,
          "y" : 1423
        },
        "to" : {
          "x" : 1538,
          "y" : 1398
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 353,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1121,
      "y" : 689
    },
    "isFadeOut" : true,
    "minX" : 1101,
    "maxX" : 1170,
    "minY" : 639,
    "maxY" : 704,
    "prop" : {
      "x" : 1101,
      "y" : 674,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1104,
      "y" : 678
    },
    "connectors" : [ {
      "edgeId" : 351,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1135,
          "y" : 671
        },
        "to" : {
          "x" : 1170,
          "y" : 639
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2913,
    "reactomeId" : 5674139,
    "displayName" : "PAQR3:inactive RAFs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1537,
      "y" : 1306
    },
    "isFadeOut" : true,
    "minX" : 1490,
    "maxX" : 1584,
    "minY" : 1285,
    "maxY" : 1327,
    "prop" : {
      "x" : 1490,
      "y" : 1285,
      "width" : 94,
      "height" : 42
    },
    "textPosition" : {
      "x" : 1492,
      "y" : 1292
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2911,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 355,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1274,
      "y" : 691
    },
    "isFadeOut" : true,
    "minX" : 1222,
    "maxX" : 1295,
    "minY" : 637,
    "maxY" : 706,
    "prop" : {
      "x" : 1253,
      "y" : 676,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1264,
      "y" : 680
    },
    "connectors" : [ {
      "edgeId" : 351,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1259,
          "y" : 673
        },
        "to" : {
          "x" : 1222,
          "y" : 637
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1251,
          "y" : 671
        },
        "b" : {
          "x" : 1259,
          "y" : 673
        },
        "c" : {
          "x" : 1257,
          "y" : 665
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1257,
          "y" : 665
        }
      }
    } ]
  }, {
    "id" : 356,
    "reactomeId" : 196206,
    "displayName" : "PP2A",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1205,
      "y" : 705
    },
    "isFadeOut" : true,
    "minX" : 1176,
    "maxX" : 1413,
    "minY" : 647,
    "maxY" : 885,
    "prop" : {
      "x" : 1176,
      "y" : 691,
      "width" : 59,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1185,
      "y" : 699
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 669,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1221,
          "y" : 723
        },
        "to" : {
          "x" : 1406,
          "y" : 879
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1409,
          "y" : 881
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1409,
          "y" : 881
        }
      }
    }, {
      "edgeId" : 351,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1203,
          "y" : 688
        },
        "to" : {
          "x" : 1200,
          "y" : 655
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1200,
          "y" : 651
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1200,
          "y" : 651
        }
      }
    } ]
  }, {
    "id" : 359,
    "reactomeId" : 5672729,
    "displayName" : "p21 RAS:GTP:'activator' RAF:YWHAB dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1493,
      "y" : 376
    },
    "isFadeOut" : true,
    "minX" : 1445,
    "maxX" : 1600,
    "minY" : 337,
    "maxY" : 415,
    "prop" : {
      "x" : 1445,
      "y" : 337,
      "width" : 97,
      "height" : 78
    },
    "textPosition" : {
      "x" : 1443,
      "y" : 352
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 645,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1545,
          "y" : 376
        },
        "to" : {
          "x" : 1600,
          "y" : 377
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 357,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 165483,
    "reactomeId" : 6802720,
    "displayName" : "BRAF/RAF fusion dimers",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1737,
      "y" : 374
    },
    "isDisease" : true,
    "minX" : 1664,
    "maxX" : 1981,
    "minY" : 339,
    "maxY" : 409,
    "prop" : {
      "x" : 1664,
      "y" : 339,
      "width" : 146,
      "height" : 70
    },
    "textPosition" : {
      "x" : 1681,
      "y" : 356
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 165482,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1816,
          "y" : 375
        },
        "to" : {
          "x" : 1981,
          "y" : 380
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 165486,
    "reactomeId" : 6802710,
    "displayName" : "p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2773,
      "y" : 228
    },
    "isDisease" : true,
    "minX" : 2673,
    "maxX" : 2993,
    "minY" : 173,
    "maxY" : 306,
    "prop" : {
      "x" : 2705,
      "y" : 196,
      "width" : 137,
      "height" : 64
    },
    "textPosition" : {
      "x" : 2711,
      "y" : 197
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2842,
          "y" : 196
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2842,
          "y" : 196
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 165485,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2845,
          "y" : 245
        },
        "to" : {
          "x" : 2946,
          "y" : 271
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    }, {
      "edgeId" : 165485,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2845,
          "y" : 206
        },
        "to" : {
          "x" : 2946,
          "y" : 173
        }
      }, {
        "from" : {
          "x" : 2946,
          "y" : 173
        },
        "to" : {
          "x" : 2987,
          "y" : 275
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2989,
          "y" : 279
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2989,
          "y" : 279
        }
      },
      "isDisease" : true
    }, {
      "edgeId" : 165490,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2731,
          "y" : 263
        },
        "to" : {
          "x" : 2673,
          "y" : 306
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2728,
          "y" : 270
        },
        "b" : {
          "x" : 2731,
          "y" : 263
        },
        "c" : {
          "x" : 2723,
          "y" : 264
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2723,
          "y" : 264
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 165487,
    "reactomeId" : 6802711,
    "displayName" : "p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3257,
      "y" : 263
    },
    "isDisease" : true,
    "minX" : 3036,
    "maxX" : 3332,
    "minY" : 226,
    "maxY" : 294,
    "prop" : {
      "x" : 3189,
      "y" : 232,
      "width" : 137,
      "height" : 62
    },
    "textPosition" : {
      "x" : 3195,
      "y" : 217
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3326,
          "y" : 232
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3326,
          "y" : 232
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 165485,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3186,
          "y" : 268
        },
        "to" : {
          "x" : 3036,
          "y" : 281
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3179,
          "y" : 273
        },
        "b" : {
          "x" : 3186,
          "y" : 268
        },
        "c" : {
          "x" : 3179,
          "y" : 265
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3179,
          "y" : 265
        }
      },
      "isDisease" : true
    }, {
      "edgeId" : 165491,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 165484,
    "reactomeId" : 6802698,
    "displayName" : "p-BRAF/RAF fusion dimers",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2173,
      "y" : 388
    },
    "isDisease" : true,
    "minX" : 2078,
    "maxX" : 2316,
    "minY" : 356,
    "maxY" : 420,
    "prop" : {
      "x" : 2113,
      "y" : 356,
      "width" : 120,
      "height" : 64
    },
    "textPosition" : {
      "x" : 2111,
      "y" : 370
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 165482,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2107,
          "y" : 383
        },
        "to" : {
          "x" : 2078,
          "y" : 381
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2100,
          "y" : 387
        },
        "b" : {
          "x" : 2107,
          "y" : 383
        },
        "c" : {
          "x" : 2100,
          "y" : 379
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2100,
          "y" : 379
        }
      },
      "isDisease" : true
    }, {
      "edgeId" : 165488,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2239,
          "y" : 384
        },
        "to" : {
          "x" : 2316,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 165489,
    "reactomeId" : 6802695,
    "displayName" : "p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2518,
      "y" : 375
    },
    "isDisease" : true,
    "minX" : 2469,
    "maxX" : 2624,
    "minY" : 339,
    "maxY" : 406,
    "prop" : {
      "x" : 2469,
      "y" : 345,
      "width" : 98,
      "height" : 61
    },
    "textPosition" : {
      "x" : 2470,
      "y" : 315
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2567,
          "y" : 345
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2567,
          "y" : 345
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 165490,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2570,
          "y" : 358
        },
        "to" : {
          "x" : 2599,
          "y" : 348
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    }, {
      "edgeId" : 165490,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2570,
          "y" : 380
        },
        "to" : {
          "x" : 2589,
          "y" : 383
        }
      }, {
        "from" : {
          "x" : 2589,
          "y" : 383
        },
        "to" : {
          "x" : 2617,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2620,
          "y" : 351
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2620,
          "y" : 351
        }
      },
      "isDisease" : true
    }, {
      "edgeId" : 165488,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 165492,
    "reactomeId" : 6802698,
    "displayName" : "p-BRAF/RAF fusion dimers",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3641,
      "y" : 356
    },
    "isDisease" : true,
    "minX" : 3511,
    "maxX" : 3717,
    "minY" : 334,
    "maxY" : 379,
    "prop" : {
      "x" : 3566,
      "y" : 334,
      "width" : 151,
      "height" : 45
    },
    "textPosition" : {
      "x" : 3579,
      "y" : 339
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 165491,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3560,
          "y" : 354
        },
        "to" : {
          "x" : 3511,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3553,
          "y" : 358
        },
        "b" : {
          "x" : 3560,
          "y" : 354
        },
        "c" : {
          "x" : 3553,
          "y" : 350
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3553,
          "y" : 350
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 2935,
    "reactomeId" : 5674277,
    "displayName" : "IL17RD",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1765,
      "y" : 1484
    },
    "isFadeOut" : true,
    "minX" : 1729,
    "maxX" : 1801,
    "minY" : 1434,
    "maxY" : 1501,
    "prop" : {
      "x" : 1729,
      "y" : 1467,
      "width" : 72,
      "height" : 34
    },
    "textPosition" : {
      "x" : 1740,
      "y" : 1473
    },
    "connectors" : [ {
      "edgeId" : 2934,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1767,
          "y" : 1464
        },
        "to" : {
          "x" : 1771,
          "y" : 1434
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2936,
    "reactomeId" : 5674360,
    "displayName" : "IL17RD:p-2S MAP2Ks:MAPKs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1756,
      "y" : 1334
    },
    "isFadeOut" : true,
    "minX" : 1698,
    "maxX" : 1814,
    "minY" : 1256,
    "maxY" : 1364,
    "prop" : {
      "x" : 1698,
      "y" : 1305,
      "width" : 116,
      "height" : 59
    },
    "textPosition" : {
      "x" : 1706,
      "y" : 1329
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2934,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2937,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1763,
          "y" : 1302
        },
        "to" : {
          "x" : 1770,
          "y" : 1279
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2937,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1734,
          "y" : 1302
        },
        "to" : {
          "x" : 1716,
          "y" : 1279
        }
      }, {
        "from" : {
          "x" : 1716,
          "y" : 1279
        },
        "to" : {
          "x" : 1758,
          "y" : 1261
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1762,
          "y" : 1260
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1762,
          "y" : 1260
        }
      }
    } ]
  }, {
    "id" : 2938,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1848,
      "y" : 1280
    },
    "isFadeOut" : true,
    "minX" : 1770,
    "maxX" : 1868,
    "minY" : 1265,
    "maxY" : 1295,
    "prop" : {
      "x" : 1828,
      "y" : 1265,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1832,
      "y" : 1269
    },
    "connectors" : [ {
      "edgeId" : 2937,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1825,
          "y" : 1279
        },
        "to" : {
          "x" : 1770,
          "y" : 1279
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1791,
            "y" : 1273
          },
          "b" : {
            "x" : 1803,
            "y" : 1285
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1797,
            "y" : 1279
          }
        }
      }
    } ]
  }, {
    "id" : 13435,
    "reactomeId" : 9660479,
    "displayName" : "RAL GDS proteins",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 796,
      "y" : 795
    },
    "isFadeOut" : true,
    "minX" : 747,
    "maxX" : 845,
    "minY" : 322,
    "maxY" : 818,
    "prop" : {
      "x" : 747,
      "y" : 773,
      "width" : 98,
      "height" : 45
    },
    "textPosition" : {
      "x" : 764,
      "y" : 778
    },
    "connectors" : [ {
      "edgeId" : 13434,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 794,
          "y" : 767
        },
        "to" : {
          "x" : 773,
          "y" : 322
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2939,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1852,
      "y" : 1229
    },
    "isFadeOut" : true,
    "minX" : 1775,
    "maxX" : 1873,
    "minY" : 1214,
    "maxY" : 1244,
    "prop" : {
      "x" : 1832,
      "y" : 1214,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1836,
      "y" : 1218
    },
    "connectors" : [ {
      "edgeId" : 2937,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1829,
          "y" : 1229
        },
        "to" : {
          "x" : 1775,
          "y" : 1232
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1796,
            "y" : 1224
          },
          "b" : {
            "x" : 1808,
            "y" : 1236
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1802,
            "y" : 1230
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1822,
          "y" : 1233
        },
        "b" : {
          "x" : 1829,
          "y" : 1229
        },
        "c" : {
          "x" : 1822,
          "y" : 1225
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1822,
          "y" : 1225
        }
      }
    } ]
  }, {
    "id" : 3451,
    "reactomeId" : 5675414,
    "displayName" : "p21RAS:GTP:activated RAF1 homo/heterodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2205,
      "y" : 257
    },
    "isFadeOut" : true,
    "minX" : 2143,
    "maxX" : 3831,
    "minY" : 169,
    "maxY" : 285,
    "prop" : {
      "x" : 2143,
      "y" : 229,
      "width" : 125,
      "height" : 56
    },
    "textPosition" : {
      "x" : 2143,
      "y" : 236
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 3460,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2271,
          "y" : 237
        },
        "to" : {
          "x" : 2485,
          "y" : 169
        }
      }, {
        "from" : {
          "x" : 2485,
          "y" : 169
        },
        "to" : {
          "x" : 3831,
          "y" : 171
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 3450,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2271,
          "y" : 256
        },
        "to" : {
          "x" : 2341,
          "y" : 255
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13436,
    "reactomeId" : 9660554,
    "displayName" : "S-Farn-Me_2xPalmS HRAS:GTP:RAL GDS proteins",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 882,
      "y" : 295
    },
    "isFadeOut" : true,
    "minX" : 810,
    "maxX" : 954,
    "minY" : 270,
    "maxY" : 320,
    "prop" : {
      "x" : 810,
      "y" : 270,
      "width" : 144,
      "height" : 50
    },
    "textPosition" : {
      "x" : 816,
      "y" : 271
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 13434,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2940,
    "reactomeId" : 5674362,
    "displayName" : "IL17RD:p-2S MAP2Ks:p-T,Y MAPKs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1769,
      "y" : 1190
    },
    "isFadeOut" : true,
    "minX" : 1698,
    "maxX" : 1841,
    "minY" : 1169,
    "maxY" : 1232,
    "prop" : {
      "x" : 1698,
      "y" : 1169,
      "width" : 143,
      "height" : 43
    },
    "textPosition" : {
      "x" : 1700,
      "y" : 1177
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2937,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1772,
          "y" : 1215
        },
        "to" : {
          "x" : 1775,
          "y" : 1232
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1777,
          "y" : 1221
        },
        "b" : {
          "x" : 1772,
          "y" : 1215
        },
        "c" : {
          "x" : 1769,
          "y" : 1223
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1769,
          "y" : 1223
        }
      }
    } ]
  }, {
    "id" : 3452,
    "reactomeId" : 61487,
    "displayName" : "PEBP1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2179,
      "y" : 491
    },
    "isFadeOut" : true,
    "minX" : 2140,
    "maxX" : 2341,
    "minY" : 255,
    "maxY" : 507,
    "prop" : {
      "x" : 2140,
      "y" : 476,
      "width" : 78,
      "height" : 31
    },
    "textPosition" : {
      "x" : 2155,
      "y" : 481
    },
    "connectors" : [ {
      "edgeId" : 3450,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2194,
          "y" : 473
        },
        "to" : {
          "x" : 2333,
          "y" : 341
        }
      }, {
        "from" : {
          "x" : 2333,
          "y" : 341
        },
        "to" : {
          "x" : 2341,
          "y" : 255
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13437,
    "reactomeId" : 9660551,
    "displayName" : "S-Farn-Me-2xPalmS HRAS:GTP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 657,
      "y" : 317
    },
    "isFadeOut" : true,
    "minX" : 601,
    "maxX" : 773,
    "minY" : 289,
    "maxY" : 346,
    "prop" : {
      "x" : 601,
      "y" : 289,
      "width" : 113,
      "height" : 57
    },
    "textPosition" : {
      "x" : 607,
      "y" : 297
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 13434,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 717,
          "y" : 319
        },
        "to" : {
          "x" : 773,
          "y" : 322
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3453,
    "reactomeId" : 5675413,
    "displayName" : "p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2512,
      "y" : 227
    },
    "minX" : 2424,
    "maxX" : 2597,
    "minY" : 189,
    "maxY" : 373,
    "prop" : {
      "x" : 2434,
      "y" : 195,
      "width" : 157,
      "height" : 64
    },
    "textPosition" : {
      "x" : 2435,
      "y" : 196
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2591,
          "y" : 195
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2591,
          "y" : 195
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2202,
      "type" : "INHIBITOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2493,
          "y" : 262
        },
        "to" : {
          "x" : 2427,
          "y" : 371
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2424,
          "y" : 369
        },
        "b" : {
          "x" : 2430,
          "y" : 373
        },
        "c" : {
          "x" : 2427,
          "y" : 371
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2427,
          "y" : 371
        }
      }
    }, {
      "edgeId" : 165488,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2493,
          "y" : 262
        },
        "to" : {
          "x" : 2427,
          "y" : 371
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2424,
          "y" : 369
        },
        "b" : {
          "x" : 2430,
          "y" : 373
        },
        "c" : {
          "x" : 2427,
          "y" : 371
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2427,
          "y" : 371
        }
      },
      "isDisease" : true
    }, {
      "edgeId" : 3450,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 386,
    "reactomeId" : 5672708,
    "displayName" : "inactive RAFs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 899,
      "y" : 628
    },
    "isFadeOut" : true,
    "minX" : 853,
    "maxX" : 1538,
    "minY" : 609,
    "maxY" : 1398,
    "prop" : {
      "x" : 853,
      "y" : 609,
      "width" : 93,
      "height" : 39
    },
    "textPosition" : {
      "x" : 854,
      "y" : 618
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 204
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 2911,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 900,
          "y" : 654
        },
        "to" : {
          "x" : 966,
          "y" : 1323
        }
      }, {
        "from" : {
          "x" : 966,
          "y" : 1323
        },
        "to" : {
          "x" : 1538,
          "y" : 1398
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 364,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 952,
          "y" : 627
        },
        "to" : {
          "x" : 971,
          "y" : 627
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4740,
    "reactomeId" : 449836,
    "displayName" : "Other interleukin signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 176
    },
    "isFadeOut" : true,
    "minX" : 9,
    "maxX" : 139,
    "minY" : 148,
    "maxY" : 205,
    "prop" : {
      "x" : 9,
      "y" : 148,
      "width" : 130,
      "height" : 57
    },
    "textPosition" : {
      "x" : 11,
      "y" : 155
    },
    "connectors" : [ ]
  }, {
    "id" : 3461,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3752,
      "y" : 222
    },
    "isFadeOut" : true,
    "minX" : 3723,
    "maxX" : 3831,
    "minY" : 171,
    "maxY" : 238,
    "prop" : {
      "x" : 3723,
      "y" : 206,
      "width" : 58,
      "height" : 32
    },
    "textPosition" : {
      "x" : 3735,
      "y" : 211
    },
    "connectors" : [ {
      "edgeId" : 3460,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3776,
          "y" : 203
        },
        "to" : {
          "x" : 3831,
          "y" : 171
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3462,
    "reactomeId" : 5675430,
    "displayName" : "p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4163,
      "y" : 288
    },
    "isFadeOut" : true,
    "minX" : 3905,
    "maxX" : 4353,
    "minY" : 256,
    "maxY" : 319,
    "prop" : {
      "x" : 4081,
      "y" : 257,
      "width" : 164,
      "height" : 62
    },
    "textPosition" : {
      "x" : 4082,
      "y" : 270
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 3460,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4078,
          "y" : 277
        },
        "to" : {
          "x" : 3905,
          "y" : 256
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4071,
          "y" : 280
        },
        "b" : {
          "x" : 4078,
          "y" : 277
        },
        "c" : {
          "x" : 4072,
          "y" : 272
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4072,
          "y" : 272
        }
      }
    }, {
      "edgeId" : 3472,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4248,
          "y" : 285
        },
        "to" : {
          "x" : 4353,
          "y" : 283
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3463,
    "reactomeId" : 5675402,
    "displayName" : "PPP5C",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3627,
      "y" : 539
    },
    "isFadeOut" : true,
    "minX" : 3594,
    "maxX" : 3864,
    "minY" : 214,
    "maxY" : 556,
    "prop" : {
      "x" : 3594,
      "y" : 522,
      "width" : 67,
      "height" : 34
    },
    "textPosition" : {
      "x" : 3603,
      "y" : 528
    },
    "connectors" : [ {
      "edgeId" : 3460,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3639,
          "y" : 519
        },
        "to" : {
          "x" : 3858,
          "y" : 221
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3860,
          "y" : 218
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3860,
          "y" : 218
        }
      }
    } ]
  }, {
    "id" : 648,
    "reactomeId" : 5672733,
    "displayName" : "p21 RAS:GTP:homo/heterodimerized RAF complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1737,
      "y" : 374
    },
    "isFadeOut" : true,
    "minX" : 1664,
    "maxX" : 1981,
    "minY" : 290,
    "maxY" : 409,
    "prop" : {
      "x" : 1664,
      "y" : 339,
      "width" : 146,
      "height" : 70
    },
    "textPosition" : {
      "x" : 1667,
      "y" : 360
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 645,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 813,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1813,
          "y" : 375
        },
        "to" : {
          "x" : 1981,
          "y" : 380
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 5041,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1791,
          "y" : 336
        },
        "to" : {
          "x" : 1867,
          "y" : 290
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3465,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3973,
      "y" : 331
    },
    "isFadeOut" : true,
    "minX" : 3905,
    "maxX" : 3994,
    "minY" : 256,
    "maxY" : 346,
    "prop" : {
      "x" : 3952,
      "y" : 316,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3963,
      "y" : 320
    },
    "connectors" : [ {
      "edgeId" : 3460,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3959,
          "y" : 313
        },
        "to" : {
          "x" : 3905,
          "y" : 256
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3951,
          "y" : 311
        },
        "b" : {
          "x" : 3959,
          "y" : 313
        },
        "c" : {
          "x" : 3957,
          "y" : 305
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3957,
          "y" : 305
        }
      }
    } ]
  }, {
    "id" : 3473,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4330,
      "y" : 324
    },
    "isFadeOut" : true,
    "minX" : 4306,
    "maxX" : 4354,
    "minY" : 283,
    "maxY" : 339,
    "prop" : {
      "x" : 4306,
      "y" : 309,
      "width" : 48,
      "height" : 30
    },
    "textPosition" : {
      "x" : 4313,
      "y" : 313
    },
    "connectors" : [ {
      "edgeId" : 3472,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4338,
          "y" : 306
        },
        "to" : {
          "x" : 4353,
          "y" : 283
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 6290,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1087,
      "y" : 536
    },
    "isFadeOut" : true,
    "minX" : 1062,
    "maxX" : 1143,
    "minY" : 521,
    "maxY" : 585,
    "prop" : {
      "x" : 1062,
      "y" : 521,
      "width" : 51,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1070,
      "y" : 525
    },
    "connectors" : [ {
      "edgeId" : 6289,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1104,
          "y" : 554
        },
        "to" : {
          "x" : 1143,
          "y" : 585
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3474,
    "reactomeId" : 5675412,
    "displayName" : "p21RAS:GTP:p-S621 RAF1 homo/heterodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4568,
      "y" : 285
    },
    "isFadeOut" : true,
    "minX" : 4430,
    "maxX" : 4636,
    "minY" : 250,
    "maxY" : 321,
    "prop" : {
      "x" : 4501,
      "y" : 250,
      "width" : 135,
      "height" : 71
    },
    "textPosition" : {
      "x" : 4501,
      "y" : 272
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 3472,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4498,
          "y" : 283
        },
        "to" : {
          "x" : 4430,
          "y" : 282
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4491,
          "y" : 287
        },
        "b" : {
          "x" : 4498,
          "y" : 283
        },
        "c" : {
          "x" : 4491,
          "y" : 279
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4491,
          "y" : 279
        }
      }
    } ]
  }, {
    "id" : 6291,
    "reactomeId" : 9658447,
    "displayName" : "S-GCC MRAS:GTP:SHOC2:PP1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1167,
      "y" : 460
    },
    "isFadeOut" : true,
    "minX" : 1120,
    "maxX" : 1214,
    "minY" : 431,
    "maxY" : 576,
    "prop" : {
      "x" : 1120,
      "y" : 431,
      "width" : 94,
      "height" : 59
    },
    "textPosition" : {
      "x" : 1123,
      "y" : 441
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 6289,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1167,
          "y" : 493
        },
        "to" : {
          "x" : 1170,
          "y" : 568
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1170,
          "y" : 572
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1170,
          "y" : 572
        }
      }
    } ]
  }, {
    "id" : 660,
    "reactomeId" : 5672689,
    "displayName" : "KSR1:MARK3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 972,
      "y" : 816
    },
    "isFadeOut" : true,
    "minX" : 875,
    "maxX" : 1045,
    "minY" : 793,
    "maxY" : 888,
    "prop" : {
      "x" : 935,
      "y" : 793,
      "width" : 75,
      "height" : 46
    },
    "textPosition" : {
      "x" : 948,
      "y" : 804
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 659,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 986,
          "y" : 842
        },
        "to" : {
          "x" : 1016,
          "y" : 888
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 659,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1013,
          "y" : 812
        },
        "to" : {
          "x" : 1045,
          "y" : 809
        }
      }, {
        "from" : {
          "x" : 1045,
          "y" : 809
        },
        "to" : {
          "x" : 1033,
          "y" : 873
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1032,
          "y" : 877
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1032,
          "y" : 877
        }
      }
    }, {
      "edgeId" : 2284,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 932,
          "y" : 827
        },
        "to" : {
          "x" : 875,
          "y" : 845
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3476,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4437,
      "y" : 339
    },
    "isFadeOut" : true,
    "minX" : 4416,
    "maxX" : 4458,
    "minY" : 282,
    "maxY" : 354,
    "prop" : {
      "x" : 4416,
      "y" : 324,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 4427,
      "y" : 328
    },
    "connectors" : [ {
      "edgeId" : 3472,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4435,
          "y" : 321
        },
        "to" : {
          "x" : 4430,
          "y" : 282
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4430,
          "y" : 315
        },
        "b" : {
          "x" : 4435,
          "y" : 321
        },
        "c" : {
          "x" : 4438,
          "y" : 314
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4438,
          "y" : 314
        }
      }
    } ]
  }, {
    "id" : 661,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 982,
      "y" : 928
    },
    "isFadeOut" : true,
    "minX" : 963,
    "maxX" : 1016,
    "minY" : 888,
    "maxY" : 943,
    "prop" : {
      "x" : 963,
      "y" : 913,
      "width" : 38,
      "height" : 30
    },
    "textPosition" : {
      "x" : 966,
      "y" : 917
    },
    "connectors" : [ {
      "edgeId" : 659,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 994,
          "y" : 910
        },
        "to" : {
          "x" : 1016,
          "y" : 888
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 999,
            "y" : 893
          },
          "b" : {
            "x" : 1011,
            "y" : 905
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1005,
            "y" : 899
          }
        }
      }
    } ]
  }, {
    "id" : 6293,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1280,
      "y" : 572
    },
    "isFadeOut" : true,
    "minX" : 1227,
    "maxX" : 1301,
    "minY" : 557,
    "maxY" : 587,
    "prop" : {
      "x" : 1259,
      "y" : 557,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1270,
      "y" : 561
    },
    "connectors" : [ {
      "edgeId" : 6289,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1256,
          "y" : 577
        },
        "to" : {
          "x" : 1227,
          "y" : 585
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1250,
          "y" : 583
        },
        "b" : {
          "x" : 1256,
          "y" : 577
        },
        "c" : {
          "x" : 1248,
          "y" : 575
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1248,
          "y" : 575
        }
      }
    } ]
  }, {
    "id" : 3478,
    "reactomeId" : 196206,
    "displayName" : "PP2A",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4431,
      "y" : 508
    },
    "isFadeOut" : true,
    "minX" : 4394,
    "maxX" : 4461,
    "minY" : 291,
    "maxY" : 523,
    "prop" : {
      "x" : 4402,
      "y" : 494,
      "width" : 59,
      "height" : 29
    },
    "textPosition" : {
      "x" : 4411,
      "y" : 502
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 3472,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4428,
          "y" : 491
        },
        "to" : {
          "x" : 4398,
          "y" : 299
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 4398,
          "y" : 295
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4398,
          "y" : 295
        }
      }
    } ]
  }, {
    "id" : 662,
    "reactomeId" : 5672695,
    "displayName" : "p-S311,S406 KSR1:MARK3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1140,
      "y" : 890
    },
    "isFadeOut" : true,
    "minX" : 1055,
    "maxX" : 1218,
    "minY" : 867,
    "maxY" : 914,
    "prop" : {
      "x" : 1084,
      "y" : 867,
      "width" : 113,
      "height" : 47
    },
    "textPosition" : {
      "x" : 1094,
      "y" : 879
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 659,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1081,
          "y" : 889
        },
        "to" : {
          "x" : 1055,
          "y" : 889
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1074,
          "y" : 893
        },
        "b" : {
          "x" : 1081,
          "y" : 889
        },
        "c" : {
          "x" : 1074,
          "y" : 885
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1074,
          "y" : 885
        }
      }
    }, {
      "edgeId" : 665,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1200,
          "y" : 884
        },
        "to" : {
          "x" : 1218,
          "y" : 883
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 663,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1070,
      "y" : 844
    },
    "isFadeOut" : true,
    "minX" : 1051,
    "maxX" : 1090,
    "minY" : 829,
    "maxY" : 889,
    "prop" : {
      "x" : 1051,
      "y" : 829,
      "width" : 39,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1054,
      "y" : 833
    },
    "connectors" : [ {
      "edgeId" : 659,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1065,
          "y" : 862
        },
        "to" : {
          "x" : 1055,
          "y" : 889
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1054,
            "y" : 869
          },
          "b" : {
            "x" : 1066,
            "y" : 881
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1060,
            "y" : 875
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1066,
          "y" : 870
        },
        "b" : {
          "x" : 1065,
          "y" : 862
        },
        "c" : {
          "x" : 1059,
          "y" : 867
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1059,
          "y" : 867
        }
      }
    } ]
  }, {
    "id" : 666,
    "reactomeId" : 5672696,
    "displayName" : "p-S311,S406 KSR1:MARK3:YWHAB dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1316,
      "y" : 894
    },
    "isFadeOut" : true,
    "minX" : 1254,
    "maxX" : 1402,
    "minY" : 869,
    "maxY" : 920,
    "prop" : {
      "x" : 1254,
      "y" : 869,
      "width" : 125,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1270,
      "y" : 871
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 665,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 669,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1382,
          "y" : 892
        },
        "to" : {
          "x" : 1402,
          "y" : 892
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3483,
    "reactomeId" : 449607,
    "displayName" : "MAP3K11",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1625,
      "y" : 557
    },
    "isFadeOut" : true,
    "minX" : 1588,
    "maxX" : 1663,
    "minY" : 385,
    "maxY" : 573,
    "prop" : {
      "x" : 1588,
      "y" : 541,
      "width" : 75,
      "height" : 32
    },
    "textPosition" : {
      "x" : 1593,
      "y" : 546
    },
    "connectors" : [ {
      "edgeId" : 645,
      "type" : "ACTIVATOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1623,
          "y" : 538
        },
        "to" : {
          "x" : 1614,
          "y" : 385
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1618,
          "y" : 392
        },
        "b" : {
          "x" : 1614,
          "y" : 385
        },
        "c" : {
          "x" : 1610,
          "y" : 392
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1610,
          "y" : 392
        }
      }
    } ]
  }, {
    "id" : 2203,
    "reactomeId" : 169291,
    "displayName" : "MAPKs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2451,
      "y" : 607
    },
    "minX" : 1771,
    "maxX" : 2621,
    "minY" : 379,
    "maxY" : 1434,
    "prop" : {
      "x" : 2427,
      "y" : 596,
      "width" : 49,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2427,
      "y" : 596
    },
    "connectors" : [ {
      "edgeId" : 2202,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2444,
          "y" : 590
        },
        "to" : {
          "x" : 2316,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2869,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2455,
          "y" : 624
        },
        "to" : {
          "x" : 2621,
          "y" : 1006
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 165488,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2444,
          "y" : 590
        },
        "to" : {
          "x" : 2316,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    }, {
      "edgeId" : 2934,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2441,
          "y" : 624
        },
        "to" : {
          "x" : 1771,
          "y" : 1434
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2204,
    "reactomeId" : 5672716,
    "displayName" : "MAP2K homo/heterodimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2317,
      "y" : 556
    },
    "minX" : 2255,
    "maxX" : 2621,
    "minY" : 379,
    "maxY" : 1006,
    "prop" : {
      "x" : 2255,
      "y" : 531,
      "width" : 125,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2255,
      "y" : 531
    },
    "connectors" : [ {
      "edgeId" : 2202,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2316,
          "y" : 525
        },
        "to" : {
          "x" : 2316,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2869,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2333,
          "y" : 587
        },
        "to" : {
          "x" : 2621,
          "y" : 1006
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 165488,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2316,
          "y" : 525
        },
        "to" : {
          "x" : 2316,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 2205,
    "reactomeId" : 5672717,
    "displayName" : "RAF/MAPK scaffolds",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2089,
      "y" : 778
    },
    "minX" : 2025,
    "maxX" : 3511,
    "minY" : 354,
    "maxY" : 789,
    "prop" : {
      "x" : 2025,
      "y" : 767,
      "width" : 129,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2025,
      "y" : 767
    },
    "connectors" : [ {
      "edgeId" : 2202,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2095,
          "y" : 761
        },
        "to" : {
          "x" : 2316,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2263,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2160,
          "y" : 778
        },
        "to" : {
          "x" : 3204,
          "y" : 788
        }
      }, {
        "from" : {
          "x" : 3204,
          "y" : 788
        },
        "to" : {
          "x" : 3511,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2167,
          "y" : 774
        },
        "b" : {
          "x" : 2160,
          "y" : 778
        },
        "c" : {
          "x" : 2167,
          "y" : 782
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2167,
          "y" : 782
        }
      }
    }, {
      "edgeId" : 165491,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2160,
          "y" : 778
        },
        "to" : {
          "x" : 3204,
          "y" : 788
        }
      }, {
        "from" : {
          "x" : 3204,
          "y" : 788
        },
        "to" : {
          "x" : 3511,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2167,
          "y" : 774
        },
        "b" : {
          "x" : 2160,
          "y" : 778
        },
        "c" : {
          "x" : 2167,
          "y" : 782
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2167,
          "y" : 782
        }
      },
      "isDisease" : true
    }, {
      "edgeId" : 165488,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2095,
          "y" : 761
        },
        "to" : {
          "x" : 2316,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 2206,
    "reactomeId" : 5672720,
    "displayName" : "activated RAF:scaffold:MAP2K:MAPK complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2518,
      "y" : 375
    },
    "isFadeOut" : true,
    "minX" : 2469,
    "maxX" : 2624,
    "minY" : 345,
    "maxY" : 442,
    "prop" : {
      "x" : 2469,
      "y" : 345,
      "width" : 98,
      "height" : 61
    },
    "textPosition" : {
      "x" : 2469,
      "y" : 343
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2202,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2209,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2570,
          "y" : 358
        },
        "to" : {
          "x" : 2599,
          "y" : 348
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2209,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2570,
          "y" : 380
        },
        "to" : {
          "x" : 2589,
          "y" : 383
        }
      }, {
        "from" : {
          "x" : 2589,
          "y" : 383
        },
        "to" : {
          "x" : 2617,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2620,
          "y" : 351
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2620,
          "y" : 351
        }
      }
    }, {
      "edgeId" : 5211,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2542,
          "y" : 409
        },
        "to" : {
          "x" : 2571,
          "y" : 442
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 670,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1375,
      "y" : 956
    },
    "isFadeOut" : true,
    "minX" : 1355,
    "maxX" : 1402,
    "minY" : 892,
    "maxY" : 971,
    "prop" : {
      "x" : 1355,
      "y" : 941,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1358,
      "y" : 945
    },
    "connectors" : [ {
      "edgeId" : 669,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1381,
          "y" : 938
        },
        "to" : {
          "x" : 1402,
          "y" : 892
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 671,
    "reactomeId" : 5672692,
    "displayName" : "p-S311 KSR1:MARK3:YWHAB dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1523,
      "y" : 895
    },
    "isFadeOut" : true,
    "minX" : 1440,
    "maxX" : 1577,
    "minY" : 863,
    "maxY" : 927,
    "prop" : {
      "x" : 1469,
      "y" : 863,
      "width" : 108,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1473,
      "y" : 878
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 669,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1466,
          "y" : 890
        },
        "to" : {
          "x" : 1440,
          "y" : 888
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1459,
          "y" : 893
        },
        "b" : {
          "x" : 1466,
          "y" : 890
        },
        "c" : {
          "x" : 1459,
          "y" : 885
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1459,
          "y" : 885
        }
      }
    }, {
      "edgeId" : 2229,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13472,
    "reactomeId" : 9648002,
    "displayName" : "RAS processing",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 400,
      "y" : 845
    },
    "isFadeOut" : true,
    "minX" : 351,
    "maxX" : 450,
    "minY" : 808,
    "maxY" : 883,
    "prop" : {
      "x" : 351,
      "y" : 808,
      "width" : 99,
      "height" : 75
    },
    "textPosition" : {
      "x" : 358,
      "y" : 824
    },
    "connectors" : [ ]
  }, {
    "id" : 2211,
    "reactomeId" : 5672723,
    "displayName" : "activated RAF:scaffold:p-2S MAP2K:MAPK complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2773,
      "y" : 228
    },
    "isFadeOut" : true,
    "minX" : 2673,
    "maxX" : 3027,
    "minY" : 173,
    "maxY" : 455,
    "prop" : {
      "x" : 2705,
      "y" : 196,
      "width" : 137,
      "height" : 64
    },
    "textPosition" : {
      "x" : 2725,
      "y" : 197
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2209,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2731,
          "y" : 263
        },
        "to" : {
          "x" : 2673,
          "y" : 306
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2728,
          "y" : 270
        },
        "b" : {
          "x" : 2731,
          "y" : 263
        },
        "c" : {
          "x" : 2723,
          "y" : 264
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2723,
          "y" : 264
        }
      }
    }, {
      "edgeId" : 5290,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2827,
          "y" : 263
        },
        "to" : {
          "x" : 3027,
          "y" : 378
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    }, {
      "edgeId" : 2253,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2845,
          "y" : 245
        },
        "to" : {
          "x" : 2946,
          "y" : 271
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2253,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2845,
          "y" : 206
        },
        "to" : {
          "x" : 2946,
          "y" : 173
        }
      }, {
        "from" : {
          "x" : 2946,
          "y" : 173
        },
        "to" : {
          "x" : 2987,
          "y" : 275
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2989,
          "y" : 279
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2989,
          "y" : 279
        }
      }
    }, {
      "edgeId" : 5213,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2774,
          "y" : 263
        },
        "to" : {
          "x" : 2783,
          "y" : 455
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 2212,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2742,
      "y" : 328
    },
    "minX" : 2673,
    "maxX" : 2763,
    "minY" : 306,
    "maxY" : 343,
    "prop" : {
      "x" : 2722,
      "y" : 313,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2725,
      "y" : 317
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2757,
          "y" : 318
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2757,
          "y" : 318
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2209,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2719,
          "y" : 321
        },
        "to" : {
          "x" : 2673,
          "y" : 306
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2690,
            "y" : 307
          },
          "b" : {
            "x" : 2702,
            "y" : 319
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2696,
            "y" : 313
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2711,
          "y" : 323
        },
        "b" : {
          "x" : 2719,
          "y" : 321
        },
        "c" : {
          "x" : 2714,
          "y" : 315
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2714,
          "y" : 315
        }
      }
    }, {
      "edgeId" : 165490,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2719,
          "y" : 321
        },
        "to" : {
          "x" : 2673,
          "y" : 306
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2690,
            "y" : 307
          },
          "b" : {
            "x" : 2702,
            "y" : 319
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2696,
            "y" : 313
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2711,
          "y" : 323
        },
        "b" : {
          "x" : 2719,
          "y" : 321
        },
        "c" : {
          "x" : 2714,
          "y" : 315
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2714,
          "y" : 315
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 3492,
    "reactomeId" : 202733,
    "displayName" : "Cell surface interactions at the vascular wall",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 1319
    },
    "isFadeOut" : true,
    "minX" : 5,
    "maxX" : 144,
    "minY" : 1276,
    "maxY" : 1362,
    "prop" : {
      "x" : 5,
      "y" : 1276,
      "width" : 139,
      "height" : 86
    },
    "textPosition" : {
      "x" : 6,
      "y" : 1290
    },
    "connectors" : [ ]
  }, {
    "id" : 3495,
    "reactomeId" : 2172127,
    "displayName" : "DAP12 interactions",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 1238
    },
    "isFadeOut" : true,
    "minX" : 3,
    "maxX" : 145,
    "minY" : 1208,
    "maxY" : 1268,
    "prop" : {
      "x" : 3,
      "y" : 1208,
      "width" : 142,
      "height" : 60
    },
    "textPosition" : {
      "x" : 6,
      "y" : 1223
    },
    "connectors" : [ ]
  }, {
    "id" : 3496,
    "reactomeId" : 2454202,
    "displayName" : "Fc epsilon receptor (FCERI) signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 1169
    },
    "isFadeOut" : true,
    "minX" : 3,
    "maxX" : 145,
    "minY" : 1138,
    "maxY" : 1201,
    "prop" : {
      "x" : 3,
      "y" : 1138,
      "width" : 142,
      "height" : 63
    },
    "textPosition" : {
      "x" : 3,
      "y" : 1148
    },
    "connectors" : [ ]
  }, {
    "id" : 3497,
    "reactomeId" : 451927,
    "displayName" : "Interleukin-2 family signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 1099
    },
    "isFadeOut" : true,
    "minX" : 4,
    "maxX" : 144,
    "minY" : 1072,
    "maxY" : 1127,
    "prop" : {
      "x" : 4,
      "y" : 1072,
      "width" : 140,
      "height" : 55
    },
    "textPosition" : {
      "x" : 5,
      "y" : 1078
    },
    "connectors" : [ ]
  }, {
    "id" : 5289,
    "reactomeId" : 9657590,
    "displayName" : "activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3127,
      "y" : 391
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 2998,
    "maxX" : 3187,
    "minY" : 292,
    "maxY" : 430,
    "prop" : {
      "x" : 3067,
      "y" : 352,
      "width" : 120,
      "height" : 78
    },
    "textPosition" : {
      "x" : 3067,
      "y" : 353
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 5290,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    }, {
      "edgeId" : 2253,
      "type" : "INHIBITOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3075,
          "y" : 349
        },
        "to" : {
          "x" : 3000,
          "y" : 295
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2998,
          "y" : 298
        },
        "b" : {
          "x" : 3002,
          "y" : 292
        },
        "c" : {
          "x" : 3000,
          "y" : 295
        },
        "type" : "STOP",
        "centre" : {
          "x" : 3000,
          "y" : 295
        }
      }
    }, {
      "edgeId" : 165485,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 3075,
          "y" : 349
        },
        "to" : {
          "x" : 3000,
          "y" : 295
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2998,
          "y" : 298
        },
        "b" : {
          "x" : 3002,
          "y" : 292
        },
        "c" : {
          "x" : 3000,
          "y" : 295
        },
        "type" : "STOP",
        "centre" : {
          "x" : 3000,
          "y" : 295
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 3498,
    "reactomeId" : 512988,
    "displayName" : "Interleukin-3, Interleukin-5 and GM-CSF signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 1409
    },
    "isFadeOut" : true,
    "minX" : 3,
    "maxX" : 145,
    "minY" : 1370,
    "maxY" : 1449,
    "prop" : {
      "x" : 3,
      "y" : 1370,
      "width" : 142,
      "height" : 79
    },
    "textPosition" : {
      "x" : 11,
      "y" : 1381
    },
    "connectors" : [ ]
  }, {
    "id" : 5291,
    "reactomeId" : 9657570,
    "displayName" : "dual mechanism MAPK inhibitors",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2924,
      "y" : 503
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 2853,
    "maxX" : 3027,
    "minY" : 378,
    "maxY" : 528,
    "prop" : {
      "x" : 2853,
      "y" : 479,
      "width" : 142,
      "height" : 49
    },
    "textPosition" : {
      "x" : 2867,
      "y" : 486
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 5290,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2944,
          "y" : 473
        },
        "to" : {
          "x" : 3027,
          "y" : 378
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 3499,
    "reactomeId" : 375165,
    "displayName" : "NCAM signaling for neurite out-growth",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 1602
    },
    "isFadeOut" : true,
    "minX" : 0,
    "maxX" : 148,
    "minY" : 1565,
    "maxY" : 1640,
    "prop" : {
      "x" : 0,
      "y" : 1565,
      "width" : 148,
      "height" : 75
    },
    "textPosition" : {
      "x" : 6,
      "y" : 1581
    },
    "connectors" : [ ]
  }, {
    "id" : 3500,
    "reactomeId" : 112314,
    "displayName" : "Neurotransmitter receptors and postsynaptic signal transmission",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 1508
    },
    "isFadeOut" : true,
    "minX" : 2,
    "maxX" : 146,
    "minY" : 1459,
    "maxY" : 1558,
    "prop" : {
      "x" : 2,
      "y" : 1459,
      "width" : 144,
      "height" : 99
    },
    "textPosition" : {
      "x" : 3,
      "y" : 1473
    },
    "connectors" : [ ]
  }, {
    "id" : 6316,
    "reactomeId" : 74693,
    "displayName" : "PI3K",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 631,
      "y" : 502
    },
    "isFadeOut" : true,
    "minX" : 605,
    "maxX" : 658,
    "minY" : 408,
    "maxY" : 514,
    "prop" : {
      "x" : 605,
      "y" : 491,
      "width" : 53,
      "height" : 23
    },
    "textPosition" : {
      "x" : 614,
      "y" : 493
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 6315,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 631,
          "y" : 488
        },
        "to" : {
          "x" : 638,
          "y" : 408
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3501,
    "reactomeId" : 177929,
    "displayName" : "Signaling by EGFR",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 246
    },
    "isFadeOut" : true,
    "minX" : 1,
    "maxX" : 147,
    "minY" : 217,
    "maxY" : 275,
    "prop" : {
      "x" : 1,
      "y" : 217,
      "width" : 146,
      "height" : 58
    },
    "textPosition" : {
      "x" : 10,
      "y" : 231
    },
    "connectors" : [ ]
  }, {
    "id" : 6317,
    "reactomeId" : 9658249,
    "displayName" : "p21 RAS:GTP:PI3K",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 707,
      "y" : 461
    },
    "isFadeOut" : true,
    "minX" : 662,
    "maxX" : 752,
    "minY" : 438,
    "maxY" : 484,
    "prop" : {
      "x" : 662,
      "y" : 438,
      "width" : 90,
      "height" : 46
    },
    "textPosition" : {
      "x" : 675,
      "y" : 449
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 6315,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3502,
    "reactomeId" : 1227986,
    "displayName" : "Signaling by ERBB2",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 310
    },
    "isFadeOut" : true,
    "minX" : 4,
    "maxX" : 145,
    "minY" : 283,
    "maxY" : 337,
    "prop" : {
      "x" : 4,
      "y" : 283,
      "width" : 141,
      "height" : 54
    },
    "textPosition" : {
      "x" : 7,
      "y" : 295
    },
    "connectors" : [ ]
  }, {
    "id" : 3503,
    "reactomeId" : 1236394,
    "displayName" : "Signaling by ERBB4",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 379
    },
    "isFadeOut" : true,
    "minX" : 3,
    "maxX" : 146,
    "minY" : 350,
    "maxY" : 409,
    "prop" : {
      "x" : 3,
      "y" : 350,
      "width" : 143,
      "height" : 59
    },
    "textPosition" : {
      "x" : 7,
      "y" : 365
    },
    "connectors" : [ ]
  }, {
    "id" : 3504,
    "reactomeId" : 5654736,
    "displayName" : "Signaling by FGFR1",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 452
    },
    "isFadeOut" : true,
    "minX" : 2,
    "maxX" : 146,
    "minY" : 422,
    "maxY" : 482,
    "prop" : {
      "x" : 2,
      "y" : 422,
      "width" : 144,
      "height" : 60
    },
    "textPosition" : {
      "x" : 7,
      "y" : 437
    },
    "connectors" : [ ]
  }, {
    "id" : 3505,
    "reactomeId" : 5654738,
    "displayName" : "Signaling by FGFR2",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 524
    },
    "isFadeOut" : true,
    "minX" : 3,
    "maxX" : 146,
    "minY" : 495,
    "maxY" : 554,
    "prop" : {
      "x" : 3,
      "y" : 495,
      "width" : 143,
      "height" : 59
    },
    "textPosition" : {
      "x" : 7,
      "y" : 510
    },
    "connectors" : [ ]
  }, {
    "id" : 3506,
    "reactomeId" : 5654741,
    "displayName" : "Signaling by FGFR3",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 598
    },
    "isFadeOut" : true,
    "minX" : 3,
    "maxX" : 146,
    "minY" : 567,
    "maxY" : 630,
    "prop" : {
      "x" : 3,
      "y" : 567,
      "width" : 143,
      "height" : 63
    },
    "textPosition" : {
      "x" : 7,
      "y" : 584
    },
    "connectors" : [ ]
  }, {
    "id" : 5299,
    "reactomeId" : 9657577,
    "displayName" : "single mechanism MAPK inhibitors",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3146,
      "y" : 507
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 3075,
    "maxX" : 3265,
    "minY" : 330,
    "maxY" : 529,
    "prop" : {
      "x" : 3075,
      "y" : 485,
      "width" : 143,
      "height" : 44
    },
    "textPosition" : {
      "x" : 3084,
      "y" : 489
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 5298,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3160,
          "y" : 479
        },
        "to" : {
          "x" : 3265,
          "y" : 330
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 3507,
    "reactomeId" : 5654743,
    "displayName" : "Signaling by FGFR4",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 670
    },
    "isFadeOut" : true,
    "minX" : 4,
    "maxX" : 144,
    "minY" : 640,
    "maxY" : 700,
    "prop" : {
      "x" : 4,
      "y" : 640,
      "width" : 140,
      "height" : 60
    },
    "textPosition" : {
      "x" : 7,
      "y" : 655
    },
    "connectors" : [ ]
  }, {
    "id" : 5043,
    "reactomeId" : 9653109,
    "displayName" : "p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1998,
      "y" : 270
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 1922,
    "maxX" : 2670,
    "minY" : 134,
    "maxY" : 334,
    "prop" : {
      "x" : 1922,
      "y" : 232,
      "width" : 152,
      "height" : 76
    },
    "textPosition" : {
      "x" : 1920,
      "y" : 245
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 2209,
      "type" : "INHIBITOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2049,
          "y" : 229
        },
        "to" : {
          "x" : 2182,
          "y" : 134
        }
      }, {
        "from" : {
          "x" : 2182,
          "y" : 134
        },
        "to" : {
          "x" : 2670,
          "y" : 137
        }
      }, {
        "from" : {
          "x" : 2670,
          "y" : 137
        },
        "to" : {
          "x" : 2630,
          "y" : 333
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2626,
          "y" : 332
        },
        "b" : {
          "x" : 2634,
          "y" : 334
        },
        "c" : {
          "x" : 2630,
          "y" : 333
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2630,
          "y" : 333
        }
      }
    }, {
      "edgeId" : 5041,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 165490,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2049,
          "y" : 229
        },
        "to" : {
          "x" : 2182,
          "y" : 134
        }
      }, {
        "from" : {
          "x" : 2182,
          "y" : 134
        },
        "to" : {
          "x" : 2670,
          "y" : 137
        }
      }, {
        "from" : {
          "x" : 2670,
          "y" : 137
        },
        "to" : {
          "x" : 2630,
          "y" : 333
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2626,
          "y" : 332
        },
        "b" : {
          "x" : 2634,
          "y" : 334
        },
        "c" : {
          "x" : 2630,
          "y" : 333
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2630,
          "y" : 333
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 3508,
    "reactomeId" : 74752,
    "displayName" : "Signaling by Insulin receptor",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 959
    },
    "isFadeOut" : true,
    "minX" : 4,
    "maxX" : 145,
    "minY" : 930,
    "maxY" : 989,
    "prop" : {
      "x" : 4,
      "y" : 930,
      "width" : 141,
      "height" : 59
    },
    "textPosition" : {
      "x" : 5,
      "y" : 938
    },
    "connectors" : [ ]
  }, {
    "id" : 2228,
    "reactomeId" : 5672726,
    "displayName" : "dephosphorylated inactive RAFs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1550,
      "y" : 644
    },
    "isFadeOut" : true,
    "minX" : 1472,
    "maxX" : 1608,
    "minY" : 612,
    "maxY" : 676,
    "prop" : {
      "x" : 1493,
      "y" : 612,
      "width" : 115,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1493,
      "y" : 626
    },
    "connectors" : [ {
      "edgeId" : 2227,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1487,
          "y" : 643
        },
        "to" : {
          "x" : 1472,
          "y" : 643
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1480,
          "y" : 647
        },
        "b" : {
          "x" : 1487,
          "y" : 643
        },
        "c" : {
          "x" : 1480,
          "y" : 639
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1480,
          "y" : 639
        }
      }
    } ]
  }, {
    "id" : 5300,
    "reactomeId" : 9657592,
    "displayName" : "activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3317,
      "y" : 419
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 3242,
    "maxX" : 3392,
    "minY" : 384,
    "maxY" : 454,
    "prop" : {
      "x" : 3242,
      "y" : 384,
      "width" : 150,
      "height" : 70
    },
    "textPosition" : {
      "x" : 3242,
      "y" : 377
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 5298,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 3509,
    "reactomeId" : 186797,
    "displayName" : "Signaling by PDGF",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 830
    },
    "isFadeOut" : true,
    "minX" : 1,
    "maxX" : 148,
    "minY" : 803,
    "maxY" : 857,
    "prop" : {
      "x" : 1,
      "y" : 803,
      "width" : 147,
      "height" : 54
    },
    "textPosition" : {
      "x" : 10,
      "y" : 815
    },
    "connectors" : [ ]
  }, {
    "id" : 5301,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2579,
      "y" : 307
    },
    "minX" : 2559,
    "maxX" : 2600,
    "minY" : 291,
    "maxY" : 348,
    "prop" : {
      "x" : 2559,
      "y" : 292,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2563,
      "y" : 296
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2594,
          "y" : 297
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2594,
          "y" : 297
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2209,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2586,
          "y" : 325
        },
        "to" : {
          "x" : 2599,
          "y" : 348
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2586,
            "y" : 330
          },
          "b" : {
            "x" : 2598,
            "y" : 342
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2592,
            "y" : 336
          }
        }
      }
    }, {
      "edgeId" : 165490,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2586,
          "y" : 325
        },
        "to" : {
          "x" : 2599,
          "y" : 348
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2586,
            "y" : 330
          },
          "b" : {
            "x" : 2598,
            "y" : 342
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2592,
            "y" : 336
          }
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 2230,
    "reactomeId" : 5672691,
    "displayName" : "p-S311 KSR1:MARK3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1733,
      "y" : 895
    },
    "isFadeOut" : true,
    "minX" : 1633,
    "maxX" : 1778,
    "minY" : 875,
    "maxY" : 916,
    "prop" : {
      "x" : 1688,
      "y" : 875,
      "width" : 90,
      "height" : 41
    },
    "textPosition" : {
      "x" : 1691,
      "y" : 881
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2229,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1685,
          "y" : 893
        },
        "to" : {
          "x" : 1633,
          "y" : 891
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1678,
          "y" : 897
        },
        "b" : {
          "x" : 1685,
          "y" : 893
        },
        "c" : {
          "x" : 1678,
          "y" : 889
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1678,
          "y" : 889
        }
      }
    } ]
  }, {
    "id" : 3510,
    "reactomeId" : 1433557,
    "displayName" : "Signaling by SCF-KIT",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 893
    },
    "isFadeOut" : true,
    "minX" : 3,
    "maxX" : 145,
    "minY" : 864,
    "maxY" : 923,
    "prop" : {
      "x" : 3,
      "y" : 864,
      "width" : 142,
      "height" : 59
    },
    "textPosition" : {
      "x" : 4,
      "y" : 879
    },
    "connectors" : [ ]
  }, {
    "id" : 3511,
    "reactomeId" : 2404192,
    "displayName" : "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 1703
    },
    "isFadeOut" : true,
    "minX" : 1,
    "maxX" : 147,
    "minY" : 1654,
    "maxY" : 1752,
    "prop" : {
      "x" : 1,
      "y" : 1654,
      "width" : 146,
      "height" : 98
    },
    "textPosition" : {
      "x" : 4,
      "y" : 1667
    },
    "connectors" : [ ]
  }, {
    "id" : 3512,
    "reactomeId" : 983705,
    "displayName" : "Signaling by the B Cell Receptor (BCR)",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 1030
    },
    "isFadeOut" : true,
    "minX" : 4,
    "maxX" : 145,
    "minY" : 996,
    "maxY" : 1064,
    "prop" : {
      "x" : 4,
      "y" : 996,
      "width" : 141,
      "height" : 68
    },
    "textPosition" : {
      "x" : 6,
      "y" : 1008
    },
    "connectors" : [ ]
  }, {
    "id" : 3513,
    "reactomeId" : 187037,
    "displayName" : "Signaling by NTRK1 (TRKA)",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 74,
      "y" : 754
    },
    "isFadeOut" : true,
    "minX" : 0,
    "maxX" : 148,
    "minY" : 711,
    "maxY" : 797,
    "prop" : {
      "x" : 0,
      "y" : 711,
      "width" : 148,
      "height" : 86
    },
    "textPosition" : {
      "x" : 5,
      "y" : 732
    },
    "connectors" : [ ]
  }, {
    "id" : 2234,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1443,
      "y" : 946
    },
    "isFadeOut" : true,
    "minX" : 1422,
    "maxX" : 1464,
    "minY" : 888,
    "maxY" : 961,
    "prop" : {
      "x" : 1422,
      "y" : 931,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1433,
      "y" : 935
    },
    "connectors" : [ {
      "edgeId" : 669,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1442,
          "y" : 928
        },
        "to" : {
          "x" : 1440,
          "y" : 888
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1438,
          "y" : 921
        },
        "b" : {
          "x" : 1442,
          "y" : 928
        },
        "c" : {
          "x" : 1446,
          "y" : 921
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1446,
          "y" : 921
        }
      }
    } ]
  }, {
    "id" : 2235,
    "reactomeId" : 5672731,
    "displayName" : "dephosphorylated \"receiver\" RAF/KSR1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1507,
      "y" : 510
    },
    "isFadeOut" : true,
    "minX" : 1442,
    "maxX" : 1600,
    "minY" : 377,
    "maxY" : 528,
    "prop" : {
      "x" : 1442,
      "y" : 492,
      "width" : 131,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1442,
      "y" : 492
    },
    "connectors" : [ {
      "edgeId" : 645,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1519,
          "y" : 486
        },
        "to" : {
          "x" : 1600,
          "y" : 377
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3004,
    "reactomeId" : 5674340,
    "displayName" : "p-T,Y MAPK monomers and dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3961,
      "y" : 907
    },
    "isFadeOut" : true,
    "minX" : 3569,
    "maxX" : 4108,
    "minY" : 387,
    "maxY" : 1085,
    "prop" : {
      "x" : 3910,
      "y" : 882,
      "width" : 102,
      "height" : 50
    },
    "textPosition" : {
      "x" : 3908,
      "y" : 882
    },
    "connectors" : [ {
      "edgeId" : 3072,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3963,
          "y" : 876
        },
        "to" : {
          "x" : 4017,
          "y" : 395
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 4018,
          "y" : 391
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4018,
          "y" : 391
        }
      }
    }, {
      "edgeId" : 3078,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3961,
          "y" : 876
        },
        "to" : {
          "x" : 3969,
          "y" : 466
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3969,
          "y" : 462
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3969,
          "y" : 462
        }
      }
    }, {
      "edgeId" : 3344,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3973,
          "y" : 876
        },
        "to" : {
          "x" : 4038,
          "y" : 758
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 3102,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4018,
          "y" : 908
        },
        "to" : {
          "x" : 4108,
          "y" : 911
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 3003,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 3038,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3904,
          "y" : 929
        },
        "to" : {
          "x" : 3577,
          "y" : 1079
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3573,
          "y" : 1081
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3573,
          "y" : 1081
        }
      }
    } ]
  }, {
    "id" : 3007,
    "reactomeId" : 5674341,
    "displayName" : "p-T,Y MAPK monomers and dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 4002,
      "y" : 1135
    },
    "isFadeOut" : true,
    "minX" : 3951,
    "maxX" : 4093,
    "minY" : 1110,
    "maxY" : 1160,
    "prop" : {
      "x" : 3951,
      "y" : 1110,
      "width" : 102,
      "height" : 50
    },
    "textPosition" : {
      "x" : 3949,
      "y" : 1110
    },
    "connectors" : [ {
      "edgeId" : 3349,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 4059,
          "y" : 1136
        },
        "to" : {
          "x" : 4093,
          "y" : 1138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 3003,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3008,
    "reactomeId" : 1268261,
    "displayName" : "p-T,Y MAPK dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3517,
      "y" : 732
    },
    "isFadeOut" : true,
    "minX" : 3465,
    "maxX" : 3630,
    "minY" : 717,
    "maxY" : 747,
    "prop" : {
      "x" : 3465,
      "y" : 717,
      "width" : 104,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3477,
      "y" : 715
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 2967,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 4805,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3575,
          "y" : 734
        },
        "to" : {
          "x" : 3630,
          "y" : 738
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4806,
    "reactomeId" : 9635737,
    "displayName" : "PTPN7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3495,
      "y" : 816
    },
    "isFadeOut" : true,
    "minX" : 3462,
    "maxX" : 3630,
    "minY" : 738,
    "maxY" : 830,
    "prop" : {
      "x" : 3462,
      "y" : 803,
      "width" : 67,
      "height" : 27
    },
    "textPosition" : {
      "x" : 3471,
      "y" : 806
    },
    "connectors" : [ {
      "edgeId" : 4805,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3518,
          "y" : 800
        },
        "to" : {
          "x" : 3630,
          "y" : 738
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4807,
    "reactomeId" : 9635740,
    "displayName" : "PTPN7:p-T,Y-MAPK dimers",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3681,
      "y" : 648
    },
    "isFadeOut" : true,
    "minX" : 3618,
    "maxX" : 3793,
    "minY" : 608,
    "maxY" : 666,
    "prop" : {
      "x" : 3618,
      "y" : 631,
      "width" : 127,
      "height" : 35
    },
    "textPosition" : {
      "x" : 3620,
      "y" : 631
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 4900,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3748,
          "y" : 644
        },
        "to" : {
          "x" : 3769,
          "y" : 643
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 4900,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3715,
          "y" : 628
        },
        "to" : {
          "x" : 3759,
          "y" : 608
        }
      }, {
        "from" : {
          "x" : 3759,
          "y" : 608
        },
        "to" : {
          "x" : 3786,
          "y" : 632
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3789,
          "y" : 635
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3789,
          "y" : 635
        }
      }
    }, {
      "edgeId" : 4805,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2254,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2908,
      "y" : 227
    },
    "minX" : 2889,
    "maxX" : 2946,
    "minY" : 211,
    "maxY" : 271,
    "prop" : {
      "x" : 2889,
      "y" : 212,
      "width" : 38,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2892,
      "y" : 216
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2922,
          "y" : 217
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2922,
          "y" : 217
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2253,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2920,
          "y" : 245
        },
        "to" : {
          "x" : 2946,
          "y" : 271
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2927,
            "y" : 252
          },
          "b" : {
            "x" : 2939,
            "y" : 264
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2933,
            "y" : 258
          }
        }
      }
    }, {
      "edgeId" : 165485,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2920,
          "y" : 245
        },
        "to" : {
          "x" : 2946,
          "y" : 271
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2927,
            "y" : 252
          },
          "b" : {
            "x" : 2939,
            "y" : 264
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2933,
            "y" : 258
          }
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 2255,
    "reactomeId" : 5672724,
    "displayName" : "activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3257,
      "y" : 263
    },
    "isFadeOut" : true,
    "minX" : 3036,
    "maxX" : 3326,
    "minY" : 232,
    "maxY" : 330,
    "prop" : {
      "x" : 3189,
      "y" : 232,
      "width" : 137,
      "height" : 62
    },
    "textPosition" : {
      "x" : 3197,
      "y" : 231
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 5298,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3260,
          "y" : 297
        },
        "to" : {
          "x" : 3265,
          "y" : 330
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    }, {
      "edgeId" : 2253,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3186,
          "y" : 268
        },
        "to" : {
          "x" : 3036,
          "y" : 281
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3179,
          "y" : 273
        },
        "b" : {
          "x" : 3186,
          "y" : 268
        },
        "c" : {
          "x" : 3179,
          "y" : 265
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3179,
          "y" : 265
        }
      }
    }, {
      "edgeId" : 2263,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2256,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3085,
      "y" : 215
    },
    "minX" : 3036,
    "maxX" : 3106,
    "minY" : 199,
    "maxY" : 281,
    "prop" : {
      "x" : 3065,
      "y" : 200,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3068,
      "y" : 204
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3100,
          "y" : 205
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3100,
          "y" : 205
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2253,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3073,
          "y" : 233
        },
        "to" : {
          "x" : 3036,
          "y" : 281
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3048,
            "y" : 251
          },
          "b" : {
            "x" : 3060,
            "y" : 263
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3054,
            "y" : 257
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 3072,
          "y" : 241
        },
        "b" : {
          "x" : 3073,
          "y" : 233
        },
        "c" : {
          "x" : 3066,
          "y" : 236
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3066,
          "y" : 236
        }
      }
    }, {
      "edgeId" : 165485,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3073,
          "y" : 233
        },
        "to" : {
          "x" : 3036,
          "y" : 281
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3048,
            "y" : 251
          },
          "b" : {
            "x" : 3060,
            "y" : 263
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3054,
            "y" : 257
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 3072,
          "y" : 241
        },
        "b" : {
          "x" : 3073,
          "y" : 233
        },
        "c" : {
          "x" : 3066,
          "y" : 236
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3066,
          "y" : 236
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 2264,
    "reactomeId" : 5672712,
    "displayName" : "p21RAS:GTP:activated RAF homo/heterodimers",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3641,
      "y" : 356
    },
    "isFadeOut" : true,
    "minX" : 3511,
    "maxX" : 3717,
    "minY" : 334,
    "maxY" : 379,
    "prop" : {
      "x" : 3566,
      "y" : 334,
      "width" : 151,
      "height" : 45
    },
    "textPosition" : {
      "x" : 3566,
      "y" : 330
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2263,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3563,
          "y" : 354
        },
        "to" : {
          "x" : 3511,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3556,
          "y" : 358
        },
        "b" : {
          "x" : 3563,
          "y" : 354
        },
        "c" : {
          "x" : 3556,
          "y" : 350
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3556,
          "y" : 350
        }
      }
    } ]
  }, {
    "id" : 2265,
    "reactomeId" : 169289,
    "displayName" : "p-T,Y MAPKs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3505,
      "y" : 625
    },
    "minX" : 3460,
    "maxX" : 3551,
    "minY" : 354,
    "maxY" : 666,
    "prop" : {
      "x" : 3460,
      "y" : 608,
      "width" : 91,
      "height" : 35
    },
    "textPosition" : {
      "x" : 3464,
      "y" : 615
    },
    "connectors" : [ {
      "edgeId" : 2967,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3503,
            "y" : 654
          },
          "b" : {
            "x" : 3515,
            "y" : 666
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3509,
            "y" : 660
          }
        }
      }
    }, {
      "edgeId" : 2263,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3505,
          "y" : 602
        },
        "to" : {
          "x" : 3511,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3501,
          "y" : 595
        },
        "b" : {
          "x" : 3505,
          "y" : 602
        },
        "c" : {
          "x" : 3509,
          "y" : 595
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3509,
          "y" : 595
        }
      }
    }, {
      "edgeId" : 165491,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3505,
          "y" : 602
        },
        "to" : {
          "x" : 3511,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3501,
          "y" : 595
        },
        "b" : {
          "x" : 3505,
          "y" : 602
        },
        "c" : {
          "x" : 3509,
          "y" : 595
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3509,
          "y" : 595
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 2266,
    "reactomeId" : 5672721,
    "displayName" : "p-2S MAP2K homo/heterodimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3151,
      "y" : 964
    },
    "minX" : 1771,
    "maxX" : 3511,
    "minY" : 354,
    "maxY" : 1434,
    "prop" : {
      "x" : 3089,
      "y" : 939,
      "width" : 125,
      "height" : 50
    },
    "textPosition" : {
      "x" : 3089,
      "y" : 939
    },
    "connectors" : [ {
      "edgeId" : 2263,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3165,
          "y" : 933
        },
        "to" : {
          "x" : 3511,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3165,
          "y" : 925
        },
        "b" : {
          "x" : 3165,
          "y" : 933
        },
        "c" : {
          "x" : 3172,
          "y" : 929
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3172,
          "y" : 929
        }
      }
    }, {
      "edgeId" : 165491,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3165,
          "y" : 933
        },
        "to" : {
          "x" : 3511,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3165,
          "y" : 925
        },
        "b" : {
          "x" : 3165,
          "y" : 933
        },
        "c" : {
          "x" : 3172,
          "y" : 929
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3172,
          "y" : 929
        }
      },
      "isDisease" : true
    }, {
      "edgeId" : 2934,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3145,
          "y" : 995
        },
        "to" : {
          "x" : 3119,
          "y" : 1111
        }
      }, {
        "from" : {
          "x" : 3119,
          "y" : 1111
        },
        "to" : {
          "x" : 2385,
          "y" : 1310
        }
      }, {
        "from" : {
          "x" : 2385,
          "y" : 1310
        },
        "to" : {
          "x" : 1771,
          "y" : 1434
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2268,
    "reactomeId" : 2028645,
    "displayName" : "YWHAB dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1144,
      "y" : 755
    },
    "isFadeOut" : true,
    "minX" : 971,
    "maxX" : 1633,
    "minY" : 627,
    "maxY" : 891,
    "prop" : {
      "x" : 1099,
      "y" : 744,
      "width" : 91,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1099,
      "y" : 745
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 665,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1150,
          "y" : 769
        },
        "to" : {
          "x" : 1218,
          "y" : 883
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2227,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1193,
          "y" : 753
        },
        "to" : {
          "x" : 1411,
          "y" : 749
        }
      }, {
        "from" : {
          "x" : 1411,
          "y" : 749
        },
        "to" : {
          "x" : 1472,
          "y" : 643
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1200,
          "y" : 749
        },
        "b" : {
          "x" : 1193,
          "y" : 753
        },
        "c" : {
          "x" : 1200,
          "y" : 757
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1200,
          "y" : 757
        }
      }
    }, {
      "edgeId" : 2229,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1193,
          "y" : 763
        },
        "to" : {
          "x" : 1594,
          "y" : 841
        }
      }, {
        "from" : {
          "x" : 1594,
          "y" : 841
        },
        "to" : {
          "x" : 1633,
          "y" : 891
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1201,
          "y" : 760
        },
        "b" : {
          "x" : 1193,
          "y" : 763
        },
        "c" : {
          "x" : 1199,
          "y" : 768
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1199,
          "y" : 768
        }
      }
    }, {
      "edgeId" : 364,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1129,
          "y" : 741
        },
        "to" : {
          "x" : 971,
          "y" : 627
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3039,
    "reactomeId" : 5672705,
    "displayName" : "p-2S MAP2K1:p-2S MAPK2K2 heterodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3555,
      "y" : 991
    },
    "isFadeOut" : true,
    "minX" : 3502,
    "maxX" : 3609,
    "minY" : 964,
    "maxY" : 1063,
    "prop" : {
      "x" : 3502,
      "y" : 964,
      "width" : 107,
      "height" : 55
    },
    "textPosition" : {
      "x" : 3503,
      "y" : 970
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 3038,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3556,
          "y" : 1022
        },
        "to" : {
          "x" : 3558,
          "y" : 1063
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3041,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3504,
      "y" : 1048
    },
    "isFadeOut" : true,
    "minX" : 3479,
    "maxX" : 3558,
    "minY" : 1034,
    "maxY" : 1063,
    "prop" : {
      "x" : 3479,
      "y" : 1034,
      "width" : 50,
      "height" : 28
    },
    "textPosition" : {
      "x" : 3488,
      "y" : 1037
    },
    "connectors" : [ {
      "edgeId" : 3038,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3532,
          "y" : 1054
        },
        "to" : {
          "x" : 3558,
          "y" : 1063
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3042,
    "reactomeId" : 5674489,
    "displayName" : "p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3565,
      "y" : 1159
    },
    "isFadeOut" : true,
    "minX" : 3510,
    "maxX" : 3621,
    "minY" : 1105,
    "maxY" : 1186,
    "prop" : {
      "x" : 3510,
      "y" : 1132,
      "width" : 111,
      "height" : 54
    },
    "textPosition" : {
      "x" : 3513,
      "y" : 1137
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 3038,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3563,
          "y" : 1129
        },
        "to" : {
          "x" : 3561,
          "y" : 1105
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3558,
          "y" : 1122
        },
        "b" : {
          "x" : 3563,
          "y" : 1129
        },
        "c" : {
          "x" : 3566,
          "y" : 1122
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3566,
          "y" : 1122
        }
      }
    } ]
  }, {
    "id" : 2274,
    "reactomeId" : 5672938,
    "displayName" : "BRAP",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 822,
      "y" : 511
    },
    "isFadeOut" : true,
    "minX" : 791,
    "maxX" : 875,
    "minY" : 409,
    "maxY" : 845,
    "prop" : {
      "x" : 791,
      "y" : 497,
      "width" : 62,
      "height" : 28
    },
    "textPosition" : {
      "x" : 802,
      "y" : 500
    },
    "connectors" : [ {
      "edgeId" : 2273,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 818,
          "y" : 494
        },
        "to" : {
          "x" : 795,
          "y" : 409
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2284,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 824,
          "y" : 528
        },
        "to" : {
          "x" : 875,
          "y" : 845
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2275,
    "reactomeId" : 5674003,
    "displayName" : "p21 RAS:GTP:BRAP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 878,
      "y" : 460
    },
    "isFadeOut" : true,
    "minX" : 831,
    "maxX" : 968,
    "minY" : 423,
    "maxY" : 483,
    "prop" : {
      "x" : 831,
      "y" : 437,
      "width" : 94,
      "height" : 46
    },
    "textPosition" : {
      "x" : 832,
      "y" : 448
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2273,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2276,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 928,
          "y" : 460
        },
        "to" : {
          "x" : 946,
          "y" : 461
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2276,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 921,
          "y" : 434
        },
        "to" : {
          "x" : 948,
          "y" : 423
        }
      }, {
        "from" : {
          "x" : 948,
          "y" : 423
        },
        "to" : {
          "x" : 962,
          "y" : 446
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 964,
          "y" : 450
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 964,
          "y" : 450
        }
      }
    } ]
  }, {
    "id" : 3043,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3504,
      "y" : 1114
    },
    "isFadeOut" : true,
    "minX" : 3479,
    "maxX" : 3561,
    "minY" : 1099,
    "maxY" : 1129,
    "prop" : {
      "x" : 3479,
      "y" : 1099,
      "width" : 50,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3487,
      "y" : 1103
    },
    "connectors" : [ {
      "edgeId" : 3038,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 3532,
          "y" : 1110
        },
        "to" : {
          "x" : 3561,
          "y" : 1105
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3538,
          "y" : 1105
        },
        "b" : {
          "x" : 3532,
          "y" : 1110
        },
        "c" : {
          "x" : 3540,
          "y" : 1113
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3540,
          "y" : 1113
        }
      }
    } ]
  }, {
    "id" : 2277,
    "reactomeId" : 5674005,
    "displayName" : "p21 RAS:GTP:ub-BRAP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1043,
      "y" : 460
    },
    "isFadeOut" : true,
    "minX" : 997,
    "maxX" : 1089,
    "minY" : 438,
    "maxY" : 482,
    "prop" : {
      "x" : 997,
      "y" : 438,
      "width" : 92,
      "height" : 44
    },
    "textPosition" : {
      "x" : 997,
      "y" : 447
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2276,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 5094,
    "reactomeId" : 9657579,
    "displayName" : "RAF dimer inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1973,
      "y" : 511
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 1867,
    "maxX" : 2038,
    "minY" : 290,
    "maxY" : 529,
    "prop" : {
      "x" : 1908,
      "y" : 493,
      "width" : 130,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1936,
      "y" : 493
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 5041,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1964,
          "y" : 487
        },
        "to" : {
          "x" : 1867,
          "y" : 290
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2279,
    "reactomeId" : 113595,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 921,
      "y" : 513
    },
    "isFadeOut" : true,
    "minX" : 893,
    "maxX" : 950,
    "minY" : 461,
    "maxY" : 528,
    "prop" : {
      "x" : 893,
      "y" : 498,
      "width" : 57,
      "height" : 30
    },
    "textPosition" : {
      "x" : 909,
      "y" : 502
    },
    "connectors" : [ {
      "edgeId" : 2276,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 928,
          "y" : 492
        },
        "to" : {
          "x" : 946,
          "y" : 461
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2285,
    "reactomeId" : 5674011,
    "displayName" : "BRAP:KSR1:MARK3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1150,
      "y" : 983
    },
    "isFadeOut" : true,
    "minX" : 1119,
    "maxX" : 1838,
    "minY" : 382,
    "maxY" : 1007,
    "prop" : {
      "x" : 1119,
      "y" : 959,
      "width" : 62,
      "height" : 48
    },
    "textPosition" : {
      "x" : 1125,
      "y" : 958
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 645,
      "type" : "INHIBITOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1184,
          "y" : 983
        },
        "to" : {
          "x" : 1838,
          "y" : 983
        }
      }, {
        "from" : {
          "x" : 1838,
          "y" : 983
        },
        "to" : {
          "x" : 1748,
          "y" : 584
        }
      }, {
        "from" : {
          "x" : 1748,
          "y" : 584
        },
        "to" : {
          "x" : 1618,
          "y" : 384
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1615,
          "y" : 386
        },
        "b" : {
          "x" : 1621,
          "y" : 382
        },
        "c" : {
          "x" : 1618,
          "y" : 384
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1618,
          "y" : 384
        }
      }
    }, {
      "edgeId" : 2284,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 762,
    "reactomeId" : 5672718,
    "displayName" : "p21 RAS:GTP:activated RAF homo/heterodimer complexes",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2173,
      "y" : 388
    },
    "isFadeOut" : true,
    "minX" : 2078,
    "maxX" : 2316,
    "minY" : 356,
    "maxY" : 420,
    "prop" : {
      "x" : 2113,
      "y" : 356,
      "width" : 120,
      "height" : 64
    },
    "textPosition" : {
      "x" : 2113,
      "y" : 357
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2202,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2236,
          "y" : 384
        },
        "to" : {
          "x" : 2316,
          "y" : 379
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 813,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 2110,
          "y" : 383
        },
        "to" : {
          "x" : 2078,
          "y" : 381
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2103,
          "y" : 387
        },
        "b" : {
          "x" : 2110,
          "y" : 383
        },
        "c" : {
          "x" : 2103,
          "y" : 379
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2103,
          "y" : 379
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 3072,
    "reactomeId" : 5675194,
    "displayName" : "Activated MAPK phosphorylates RAF1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4019,
      "y" : 379
    },
    "isFadeOut" : true,
    "minX" : 3988,
    "maxX" : 4051,
    "minY" : 373,
    "maxY" : 385,
    "segments" : [ {
      "from" : {
        "x" : 3988,
        "y" : 379
      },
      "to" : {
        "x" : 4019,
        "y" : 379
      }
    }, {
      "from" : {
        "x" : 4019,
        "y" : 379
      },
      "to" : {
        "x" : 4051,
        "y" : 379
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4013,
        "y" : 373
      },
      "b" : {
        "x" : 4025,
        "y" : 385
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4019,
        "y" : 379
      }
    },
    "inputs" : [ {
      "id" : 3073,
      "points" : [ {
        "x" : 3950,
        "y" : 379
      } ]
    }, {
      "id" : 3081,
      "points" : [ {
        "x" : 3913,
        "y" : 493
      } ],
      "stoichiometry" : 6
    } ],
    "outputs" : [ {
      "id" : 3077,
      "points" : [ {
        "x" : 4078,
        "y" : 378
      } ]
    }, {
      "id" : 3083,
      "points" : [ {
        "x" : 4084,
        "y" : 494
      } ],
      "stoichiometry" : 6
    } ],
    "catalysts" : [ {
      "id" : 3004,
      "points" : [ {
        "x" : 3963,
        "y" : 876
      } ]
    } ]
  }, {
    "id" : 3460,
    "reactomeId" : 5675433,
    "displayName" : "PP5 dephosphorylates RAF1 S338",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3867,
      "y" : 208
    },
    "isFadeOut" : true,
    "minX" : 3831,
    "maxX" : 3905,
    "minY" : 171,
    "maxY" : 256,
    "segments" : [ {
      "from" : {
        "x" : 3831,
        "y" : 171
      },
      "to" : {
        "x" : 3867,
        "y" : 208
      }
    }, {
      "from" : {
        "x" : 3867,
        "y" : 208
      },
      "to" : {
        "x" : 3905,
        "y" : 256
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3861,
        "y" : 202
      },
      "b" : {
        "x" : 3873,
        "y" : 214
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3867,
        "y" : 208
      }
    },
    "inputs" : [ {
      "id" : 3461,
      "points" : [ {
        "x" : 3776,
        "y" : 203
      } ]
    }, {
      "id" : 3451,
      "points" : [ {
        "x" : 2271,
        "y" : 237
      }, {
        "x" : 2485,
        "y" : 169
      } ]
    } ],
    "outputs" : [ {
      "id" : 3462,
      "points" : [ {
        "x" : 4078,
        "y" : 277
      } ]
    }, {
      "id" : 3465,
      "points" : [ {
        "x" : 3959,
        "y" : 313
      } ]
    } ],
    "catalysts" : [ {
      "id" : 3463,
      "points" : [ {
        "x" : 3639,
        "y" : 519
      } ]
    } ]
  }, {
    "id" : 645,
    "reactomeId" : 5672966,
    "displayName" : "RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1613,
      "y" : 376
    },
    "isFadeOut" : true,
    "minX" : 1600,
    "maxX" : 1661,
    "minY" : 371,
    "maxY" : 381,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 1600,
        "y" : 377
      },
      "to" : {
        "x" : 1613,
        "y" : 376
      }
    }, {
      "from" : {
        "x" : 1613,
        "y" : 376
      },
      "to" : {
        "x" : 1661,
        "y" : 375
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1654,
        "y" : 379
      },
      "b" : {
        "x" : 1661,
        "y" : 375
      },
      "c" : {
        "x" : 1654,
        "y" : 371
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1654,
        "y" : 371
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1613,
        "y" : 376
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1613,
        "y" : 376
      }
    },
    "inputs" : [ {
      "id" : 359,
      "points" : [ {
        "x" : 1545,
        "y" : 376
      } ]
    }, {
      "id" : 2235,
      "points" : [ {
        "x" : 1519,
        "y" : 486
      } ]
    } ],
    "outputs" : [ {
      "id" : 648
    } ],
    "inhibitors" : [ {
      "id" : 2285,
      "points" : [ {
        "x" : 1184,
        "y" : 983
      }, {
        "x" : 1838,
        "y" : 983
      }, {
        "x" : 1748,
        "y" : 584
      } ]
    } ],
    "activators" : [ {
      "id" : 3483,
      "points" : [ {
        "x" : 1623,
        "y" : 538
      } ]
    } ]
  }, {
    "id" : 3078,
    "reactomeId" : 5675198,
    "displayName" : "Activated MAPKs phosphorylate BRAF",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3969,
      "y" : 450
    },
    "isFadeOut" : true,
    "minX" : 3916,
    "maxX" : 3999,
    "minY" : 444,
    "maxY" : 456,
    "segments" : [ {
      "from" : {
        "x" : 3916,
        "y" : 450
      },
      "to" : {
        "x" : 3969,
        "y" : 450
      }
    }, {
      "from" : {
        "x" : 3969,
        "y" : 450
      },
      "to" : {
        "x" : 3999,
        "y" : 448
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3963,
        "y" : 444
      },
      "b" : {
        "x" : 3975,
        "y" : 456
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3969,
        "y" : 450
      }
    },
    "inputs" : [ {
      "id" : 3079,
      "points" : [ {
        "x" : 3887,
        "y" : 451
      } ]
    }, {
      "id" : 3081,
      "points" : [ {
        "x" : 3906,
        "y" : 493
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 3082,
      "points" : [ {
        "x" : 4125,
        "y" : 451
      } ]
    }, {
      "id" : 3083,
      "points" : [ {
        "x" : 4067,
        "y" : 494
      } ],
      "stoichiometry" : 4
    } ],
    "catalysts" : [ {
      "id" : 3004,
      "points" : [ {
        "x" : 3961,
        "y" : 876
      } ]
    } ]
  }, {
    "id" : 3344,
    "reactomeId" : 5675376,
    "displayName" : "Cytosolic DUSPs dephosphorylate MAPKs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4070,
      "y" : 718
    },
    "isFadeOut" : true,
    "minX" : 4038,
    "maxX" : 4135,
    "minY" : 656,
    "maxY" : 758,
    "segments" : [ {
      "from" : {
        "x" : 4038,
        "y" : 758
      },
      "to" : {
        "x" : 4070,
        "y" : 718
      }
    }, {
      "from" : {
        "x" : 4070,
        "y" : 718
      },
      "to" : {
        "x" : 4135,
        "y" : 656
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4064,
        "y" : 712
      },
      "b" : {
        "x" : 4076,
        "y" : 724
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4070,
        "y" : 718
      }
    },
    "inputs" : [ {
      "id" : 3004,
      "points" : [ {
        "x" : 3973,
        "y" : 876
      } ]
    }, {
      "id" : 3358,
      "points" : [ {
        "x" : 4048,
        "y" : 776
      } ]
    } ],
    "outputs" : [ {
      "id" : 3359,
      "points" : [ {
        "x" : 4174,
        "y" : 624
      } ]
    }, {
      "id" : 3364,
      "points" : [ {
        "x" : 4188,
        "y" : 669
      } ]
    } ],
    "catalysts" : [ {
      "id" : 3346,
      "points" : [ {
        "x" : 4148,
        "y" : 744
      } ]
    } ]
  }, {
    "id" : 3472,
    "reactomeId" : 5675431,
    "displayName" : "PP2A dephosphorylates RAF1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4396,
      "y" : 283
    },
    "isFadeOut" : true,
    "minX" : 4353,
    "maxX" : 4430,
    "minY" : 277,
    "maxY" : 289,
    "segments" : [ {
      "from" : {
        "x" : 4353,
        "y" : 283
      },
      "to" : {
        "x" : 4396,
        "y" : 283
      }
    }, {
      "from" : {
        "x" : 4396,
        "y" : 283
      },
      "to" : {
        "x" : 4430,
        "y" : 282
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4390,
        "y" : 277
      },
      "b" : {
        "x" : 4402,
        "y" : 289
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4396,
        "y" : 283
      }
    },
    "inputs" : [ {
      "id" : 3473,
      "points" : [ {
        "x" : 4338,
        "y" : 306
      } ]
    }, {
      "id" : 3462,
      "points" : [ {
        "x" : 4248,
        "y" : 285
      } ]
    } ],
    "outputs" : [ {
      "id" : 3474,
      "points" : [ {
        "x" : 4498,
        "y" : 283
      } ]
    }, {
      "id" : 3476,
      "points" : [ {
        "x" : 4435,
        "y" : 321
      } ]
    } ],
    "catalysts" : [ {
      "id" : 3478,
      "points" : [ {
        "x" : 4428,
        "y" : 491
      } ]
    } ],
    "activators" : [ {
      "id" : 3077,
      "points" : [ {
        "x" : 4262,
        "y" : 374
      }, {
        "x" : 4342,
        "y" : 374
      } ]
    } ]
  }, {
    "id" : 6289,
    "reactomeId" : 9658445,
    "displayName" : "MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1171,
      "y" : 584
    },
    "isFadeOut" : true,
    "minX" : 1143,
    "maxX" : 1227,
    "minY" : 578,
    "maxY" : 590,
    "segments" : [ {
      "from" : {
        "x" : 1143,
        "y" : 585
      },
      "to" : {
        "x" : 1171,
        "y" : 584
      }
    }, {
      "from" : {
        "x" : 1171,
        "y" : 584
      },
      "to" : {
        "x" : 1227,
        "y" : 585
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1165,
        "y" : 578
      },
      "b" : {
        "x" : 1177,
        "y" : 590
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1171,
        "y" : 584
      }
    },
    "inputs" : [ {
      "id" : 1081,
      "points" : [ {
        "x" : 1116,
        "y" : 606
      } ]
    }, {
      "id" : 6290,
      "points" : [ {
        "x" : 1104,
        "y" : 554
      } ]
    } ],
    "outputs" : [ {
      "id" : 1085,
      "points" : [ {
        "x" : 1280,
        "y" : 605
      } ]
    }, {
      "id" : 6293,
      "points" : [ {
        "x" : 1256,
        "y" : 577
      } ]
    } ],
    "catalysts" : [ {
      "id" : 6291,
      "points" : [ {
        "x" : 1167,
        "y" : 493
      } ]
    } ]
  }, {
    "id" : 659,
    "reactomeId" : 5672948,
    "displayName" : "MARK3 phosphorylates KSR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1030,
      "y" : 889
    },
    "isFadeOut" : true,
    "minX" : 1016,
    "maxX" : 1055,
    "minY" : 883,
    "maxY" : 895,
    "segments" : [ {
      "from" : {
        "x" : 1016,
        "y" : 888
      },
      "to" : {
        "x" : 1030,
        "y" : 889
      }
    }, {
      "from" : {
        "x" : 1030,
        "y" : 889
      },
      "to" : {
        "x" : 1055,
        "y" : 889
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1024,
        "y" : 883
      },
      "b" : {
        "x" : 1036,
        "y" : 895
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1030,
        "y" : 889
      }
    },
    "inputs" : [ {
      "id" : 660,
      "points" : [ {
        "x" : 986,
        "y" : 842
      } ]
    }, {
      "id" : 661,
      "points" : [ {
        "x" : 994,
        "y" : 910
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 662,
      "points" : [ {
        "x" : 1081,
        "y" : 889
      } ]
    }, {
      "id" : 663,
      "points" : [ {
        "x" : 1065,
        "y" : 862
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 660,
      "points" : [ {
        "x" : 1013,
        "y" : 812
      }, {
        "x" : 1045,
        "y" : 809
      } ]
    } ]
  }, {
    "id" : 3349,
    "reactomeId" : 5675373,
    "displayName" : "Nuclear DUSPs dephosphorylate MAPKs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4113,
      "y" : 1142
    },
    "isFadeOut" : true,
    "minX" : 4093,
    "maxX" : 4145,
    "minY" : 1136,
    "maxY" : 1148,
    "segments" : [ {
      "from" : {
        "x" : 4093,
        "y" : 1138
      },
      "to" : {
        "x" : 4113,
        "y" : 1142
      }
    }, {
      "from" : {
        "x" : 4113,
        "y" : 1142
      },
      "to" : {
        "x" : 4145,
        "y" : 1140
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4107,
        "y" : 1136
      },
      "b" : {
        "x" : 4119,
        "y" : 1148
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4113,
        "y" : 1142
      }
    },
    "inputs" : [ {
      "id" : 3355,
      "points" : [ {
        "x" : 4078,
        "y" : 1105
      } ]
    }, {
      "id" : 3007,
      "points" : [ {
        "x" : 4059,
        "y" : 1136
      } ]
    } ],
    "outputs" : [ {
      "id" : 3365,
      "points" : [ {
        "x" : 4187,
        "y" : 1139
      } ]
    }, {
      "id" : 3356,
      "points" : [ {
        "x" : 4169,
        "y" : 1104
      } ]
    } ],
    "catalysts" : [ {
      "id" : 3351,
      "points" : [ {
        "x" : 4114,
        "y" : 1181
      } ]
    } ]
  }, {
    "id" : 2967,
    "reactomeId" : 5674385,
    "displayName" : "p-T,Y MAPKs dimerize",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3511,
      "y" : 671
    },
    "isFadeOut" : true,
    "minX" : 3506,
    "maxX" : 3516,
    "minY" : 649,
    "maxY" : 711,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 3507,
        "y" : 649
      },
      "to" : {
        "x" : 3511,
        "y" : 671
      }
    }, {
      "from" : {
        "x" : 3511,
        "y" : 671
      },
      "to" : {
        "x" : 3515,
        "y" : 711
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3510,
        "y" : 705
      },
      "b" : {
        "x" : 3515,
        "y" : 711
      },
      "c" : {
        "x" : 3518,
        "y" : 704
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3518,
        "y" : 704
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3511,
        "y" : 671
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3511,
        "y" : 671
      }
    },
    "inputs" : [ {
      "id" : 2265,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 3008
    } ]
  }, {
    "id" : 665,
    "reactomeId" : 5672954,
    "displayName" : "p-S311,S406 KSR1:MARK3 binds YWHAB dimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1235,
      "y" : 888
    },
    "isFadeOut" : true,
    "minX" : 1218,
    "maxX" : 1251,
    "minY" : 883,
    "maxY" : 893,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 1218,
        "y" : 883
      },
      "to" : {
        "x" : 1235,
        "y" : 888
      }
    }, {
      "from" : {
        "x" : 1235,
        "y" : 888
      },
      "to" : {
        "x" : 1251,
        "y" : 889
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1244,
        "y" : 893
      },
      "b" : {
        "x" : 1251,
        "y" : 889
      },
      "c" : {
        "x" : 1244,
        "y" : 885
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1244,
        "y" : 885
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1235,
        "y" : 888
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1235,
        "y" : 888
      }
    },
    "inputs" : [ {
      "id" : 2268,
      "points" : [ {
        "x" : 1150,
        "y" : 769
      } ]
    }, {
      "id" : 662,
      "points" : [ {
        "x" : 1200,
        "y" : 884
      } ]
    } ],
    "outputs" : [ {
      "id" : 666
    } ]
  }, {
    "id" : 2202,
    "reactomeId" : 5672972,
    "displayName" : "MAP2Ks and MAPKs bind to the activated RAF complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2422,
      "y" : 379
    },
    "isFadeOut" : true,
    "minX" : 2316,
    "maxX" : 2466,
    "minY" : 374,
    "maxY" : 384,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 2316,
        "y" : 379
      },
      "to" : {
        "x" : 2422,
        "y" : 379
      }
    }, {
      "from" : {
        "x" : 2422,
        "y" : 379
      },
      "to" : {
        "x" : 2466,
        "y" : 377
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2459,
        "y" : 381
      },
      "b" : {
        "x" : 2466,
        "y" : 377
      },
      "c" : {
        "x" : 2459,
        "y" : 373
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2459,
        "y" : 373
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2422,
        "y" : 379
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2422,
        "y" : 379
      }
    },
    "inputs" : [ {
      "id" : 2203,
      "points" : [ {
        "x" : 2444,
        "y" : 590
      } ]
    }, {
      "id" : 762,
      "points" : [ {
        "x" : 2236,
        "y" : 384
      } ]
    }, {
      "id" : 2204,
      "points" : [ {
        "x" : 2316,
        "y" : 525
      } ]
    }, {
      "id" : 2205,
      "points" : [ {
        "x" : 2095,
        "y" : 761
      } ]
    } ],
    "outputs" : [ {
      "id" : 2206
    } ],
    "inhibitors" : [ {
      "id" : 3453,
      "points" : [ {
        "x" : 2493,
        "y" : 262
      } ]
    } ]
  }, {
    "id" : 669,
    "reactomeId" : 5672957,
    "displayName" : "PP2A dephosphorylates KSR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1418,
      "y" : 889
    },
    "isFadeOut" : true,
    "minX" : 1402,
    "maxX" : 1440,
    "minY" : 883,
    "maxY" : 895,
    "segments" : [ {
      "from" : {
        "x" : 1402,
        "y" : 892
      },
      "to" : {
        "x" : 1418,
        "y" : 889
      }
    }, {
      "from" : {
        "x" : 1418,
        "y" : 889
      },
      "to" : {
        "x" : 1440,
        "y" : 888
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1412,
        "y" : 883
      },
      "b" : {
        "x" : 1424,
        "y" : 895
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1418,
        "y" : 889
      }
    },
    "inputs" : [ {
      "id" : 666,
      "points" : [ {
        "x" : 1382,
        "y" : 892
      } ]
    }, {
      "id" : 670,
      "points" : [ {
        "x" : 1381,
        "y" : 938
      } ]
    } ],
    "outputs" : [ {
      "id" : 671,
      "points" : [ {
        "x" : 1466,
        "y" : 890
      } ]
    }, {
      "id" : 2234,
      "points" : [ {
        "x" : 1442,
        "y" : 928
      } ]
    } ],
    "catalysts" : [ {
      "id" : 356,
      "points" : [ {
        "x" : 1221,
        "y" : 723
      } ]
    } ]
  }, {
    "id" : 3102,
    "reactomeId" : 5675206,
    "displayName" : "PEA15 binds MAPK monomers and dimers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4137,
      "y" : 912
    },
    "isFadeOut" : true,
    "minX" : 4108,
    "maxX" : 4179,
    "minY" : 907,
    "maxY" : 917,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 4108,
        "y" : 911
      },
      "to" : {
        "x" : 4137,
        "y" : 912
      }
    }, {
      "from" : {
        "x" : 4137,
        "y" : 912
      },
      "to" : {
        "x" : 4179,
        "y" : 913
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4172,
        "y" : 917
      },
      "b" : {
        "x" : 4179,
        "y" : 913
      },
      "c" : {
        "x" : 4172,
        "y" : 909
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4172,
        "y" : 909
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4137,
        "y" : 912
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4137,
        "y" : 912
      }
    },
    "inputs" : [ {
      "id" : 3004,
      "points" : [ {
        "x" : 4018,
        "y" : 908
      } ]
    }, {
      "id" : 3103,
      "points" : [ {
        "x" : 4088,
        "y" : 887
      } ]
    } ],
    "outputs" : [ {
      "id" : 3104
    } ]
  }, {
    "id" : 2209,
    "reactomeId" : 5672978,
    "displayName" : "RAF phosphorylates MAP2K dimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2628,
      "y" : 342
    },
    "isFadeOut" : true,
    "minX" : 2599,
    "maxX" : 2673,
    "minY" : 306,
    "maxY" : 348,
    "segments" : [ {
      "from" : {
        "x" : 2599,
        "y" : 348
      },
      "to" : {
        "x" : 2628,
        "y" : 342
      }
    }, {
      "from" : {
        "x" : 2628,
        "y" : 342
      },
      "to" : {
        "x" : 2673,
        "y" : 306
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2622,
        "y" : 336
      },
      "b" : {
        "x" : 2634,
        "y" : 348
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2628,
        "y" : 342
      }
    },
    "inputs" : [ {
      "id" : 5301,
      "points" : [ {
        "x" : 2586,
        "y" : 325
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 2206,
      "points" : [ {
        "x" : 2570,
        "y" : 358
      } ]
    } ],
    "outputs" : [ {
      "id" : 2211,
      "points" : [ {
        "x" : 2731,
        "y" : 263
      } ]
    }, {
      "id" : 2212,
      "points" : [ {
        "x" : 2719,
        "y" : 321
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 2206,
      "points" : [ {
        "x" : 2570,
        "y" : 380
      }, {
        "x" : 2589,
        "y" : 383
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 5043,
      "points" : [ {
        "x" : 2049,
        "y" : 229
      }, {
        "x" : 2182,
        "y" : 134
      }, {
        "x" : 2670,
        "y" : 137
      } ]
    }, {
      "id" : 5210,
      "points" : [ {
        "x" : 2662,
        "y" : 383
      } ]
    } ]
  }, {
    "id" : 4900,
    "reactomeId" : 9635739,
    "displayName" : "PTPN7 dephosphorylates p-T,Y-MAPKs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3798,
      "y" : 643
    },
    "isFadeOut" : true,
    "minX" : 3769,
    "maxX" : 3832,
    "minY" : 637,
    "maxY" : 649,
    "segments" : [ {
      "from" : {
        "x" : 3769,
        "y" : 643
      },
      "to" : {
        "x" : 3798,
        "y" : 643
      }
    }, {
      "from" : {
        "x" : 3798,
        "y" : 643
      },
      "to" : {
        "x" : 3832,
        "y" : 645
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3792,
        "y" : 637
      },
      "b" : {
        "x" : 3804,
        "y" : 649
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3798,
        "y" : 643
      }
    },
    "inputs" : [ {
      "id" : 4807,
      "points" : [ {
        "x" : 3748,
        "y" : 644
      } ]
    }, {
      "id" : 4901,
      "points" : [ {
        "x" : 3757,
        "y" : 690
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 4902,
      "points" : [ {
        "x" : 3868,
        "y" : 614
      } ]
    }, {
      "id" : 4904,
      "points" : [ {
        "x" : 3840,
        "y" : 684
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 4807,
      "points" : [ {
        "x" : 3715,
        "y" : 628
      }, {
        "x" : 3759,
        "y" : 608
      } ]
    } ]
  }, {
    "id" : 4905,
    "reactomeId" : 9649736,
    "displayName" : "RAS intrinsic GTPase activity hydrolyzes GTP to GDP",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 553,
      "y" : 640
    },
    "isFadeOut" : true,
    "minX" : 436,
    "maxX" : 579,
    "minY" : 396,
    "maxY" : 711,
    "segments" : [ {
      "from" : {
        "x" : 579,
        "y" : 396
      },
      "to" : {
        "x" : 553,
        "y" : 640
      }
    }, {
      "from" : {
        "x" : 553,
        "y" : 640
      },
      "to" : {
        "x" : 436,
        "y" : 711
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 440,
        "y" : 704
      },
      "b" : {
        "x" : 436,
        "y" : 711
      },
      "c" : {
        "x" : 444,
        "y" : 711
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 444,
        "y" : 711
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 547,
        "y" : 634
      },
      "b" : {
        "x" : 559,
        "y" : 646
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 553,
        "y" : 640
      }
    },
    "inputs" : [ {
      "id" : 308
    } ],
    "outputs" : [ {
      "id" : 307
    } ],
    "catalysts" : [ {
      "id" : 308,
      "points" : [ {
        "x" : 581,
        "y" : 396
      }, {
        "x" : 581,
        "y" : 601
      } ]
    } ]
  }, {
    "id" : 5290,
    "reactomeId" : 9657603,
    "displayName" : "Dual mechanism MAPK inhibitors bind MAPKs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3045,
      "y" : 378
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 3027,
    "maxX" : 3064,
    "minY" : 373,
    "maxY" : 383,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 3027,
        "y" : 378
      },
      "to" : {
        "x" : 3045,
        "y" : 378
      }
    }, {
      "from" : {
        "x" : 3045,
        "y" : 378
      },
      "to" : {
        "x" : 3064,
        "y" : 381
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3057,
        "y" : 384
      },
      "b" : {
        "x" : 3064,
        "y" : 381
      },
      "c" : {
        "x" : 3058,
        "y" : 376
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3058,
        "y" : 376
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3045,
        "y" : 378
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3045,
        "y" : 378
      }
    },
    "inputs" : [ {
      "id" : 5291,
      "points" : [ {
        "x" : 2944,
        "y" : 473
      } ]
    }, {
      "id" : 2211,
      "points" : [ {
        "x" : 2827,
        "y" : 263
      } ]
    } ],
    "outputs" : [ {
      "id" : 5289
    } ]
  }, {
    "id" : 6315,
    "reactomeId" : 9658253,
    "displayName" : "RAS:GTP binds PI3K",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 667,
      "y" : 415
    },
    "isFadeOut" : true,
    "minX" : 638,
    "maxX" : 687,
    "minY" : 408,
    "maxY" : 435,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 638,
        "y" : 408
      },
      "to" : {
        "x" : 667,
        "y" : 415
      }
    }, {
      "from" : {
        "x" : 667,
        "y" : 415
      },
      "to" : {
        "x" : 687,
        "y" : 435
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 679,
        "y" : 433
      },
      "b" : {
        "x" : 687,
        "y" : 435
      },
      "c" : {
        "x" : 685,
        "y" : 427
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 685,
        "y" : 427
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 667,
        "y" : 415
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 667,
        "y" : 415
      }
    },
    "inputs" : [ {
      "id" : 6316,
      "points" : [ {
        "x" : 631,
        "y" : 488
      } ]
    }, {
      "id" : 308,
      "points" : [ {
        "x" : 612,
        "y" : 396
      } ]
    } ],
    "outputs" : [ {
      "id" : 6317
    } ]
  }, {
    "id" : 4907,
    "reactomeId" : 9649735,
    "displayName" : "Intrinsic nucleotide exchange on RAS",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 449,
      "y" : 578
    },
    "isFadeOut" : true,
    "minX" : 443,
    "maxX" : 461,
    "minY" : 531,
    "maxY" : 655,
    "segments" : [ {
      "from" : {
        "x" : 445,
        "y" : 655
      },
      "to" : {
        "x" : 449,
        "y" : 578
      }
    }, {
      "from" : {
        "x" : 449,
        "y" : 578
      },
      "to" : {
        "x" : 461,
        "y" : 531
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 443,
        "y" : 572
      },
      "b" : {
        "x" : 455,
        "y" : 584
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 449,
        "y" : 578
      }
    },
    "inputs" : [ {
      "id" : 307,
      "points" : [ {
        "x" : 415,
        "y" : 711
      } ]
    }, {
      "id" : 306,
      "points" : [ {
        "x" : 505,
        "y" : 614
      } ]
    } ],
    "outputs" : [ {
      "id" : 309,
      "points" : [ {
        "x" : 499,
        "y" : 518
      } ]
    }, {
      "id" : 308,
      "points" : [ {
        "x" : 566,
        "y" : 396
      } ]
    } ]
  }, {
    "id" : 813,
    "reactomeId" : 5672969,
    "displayName" : "Phosphorylation of RAF",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2053,
      "y" : 383
    },
    "isFadeOut" : true,
    "minX" : 1981,
    "maxX" : 2078,
    "minY" : 377,
    "maxY" : 389,
    "reactionType" : "Transition",
    "segments" : [ {
      "from" : {
        "x" : 1981,
        "y" : 380
      },
      "to" : {
        "x" : 2053,
        "y" : 383
      }
    }, {
      "from" : {
        "x" : 2053,
        "y" : 383
      },
      "to" : {
        "x" : 2078,
        "y" : 381
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2047,
        "y" : 377
      },
      "b" : {
        "x" : 2059,
        "y" : 389
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2053,
        "y" : 383
      }
    },
    "inputs" : [ {
      "id" : 648,
      "points" : [ {
        "x" : 1813,
        "y" : 375
      } ]
    }, {
      "id" : 819,
      "points" : [ {
        "x" : 1947,
        "y" : 350
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 820,
      "points" : [ {
        "x" : 2107,
        "y" : 329
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 762,
      "points" : [ {
        "x" : 2110,
        "y" : 383
      } ]
    } ],
    "catalysts" : [ {
      "id" : 1061,
      "points" : [ {
        "x" : 2092,
        "y" : 508
      } ]
    } ]
  }, {
    "id" : 305,
    "reactomeId" : 5672965,
    "displayName" : "RAS GEFs promote RAS nucleotide exchange",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 409,
      "y" : 544
    },
    "isFadeOut" : true,
    "minX" : 403,
    "maxX" : 416,
    "minY" : 470,
    "maxY" : 628,
    "segments" : [ {
      "from" : {
        "x" : 403,
        "y" : 628
      },
      "to" : {
        "x" : 409,
        "y" : 544
      }
    }, {
      "from" : {
        "x" : 409,
        "y" : 544
      },
      "to" : {
        "x" : 416,
        "y" : 470
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 403,
        "y" : 538
      },
      "b" : {
        "x" : 415,
        "y" : 550
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 409,
        "y" : 544
      }
    },
    "inputs" : [ {
      "id" : 306,
      "points" : [ {
        "x" : 500,
        "y" : 601
      } ]
    }, {
      "id" : 307,
      "points" : [ {
        "x" : 404,
        "y" : 711
      } ]
    } ],
    "outputs" : [ {
      "id" : 308,
      "points" : [ {
        "x" : 548,
        "y" : 396
      } ]
    }, {
      "id" : 309,
      "points" : [ {
        "x" : 499,
        "y" : 501
      } ]
    } ],
    "catalysts" : [ {
      "id" : 310,
      "points" : [ {
        "x" : 318,
        "y" : 567
      }, {
        "x" : 376,
        "y" : 537
      } ]
    } ]
  }, {
    "id" : 5041,
    "reactomeId" : 9653108,
    "displayName" : "Raf dimer inhibitors bind RAF heterodimers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1896,
      "y" : 278
    },
    "isFadeOut" : true,
    "minX" : 1867,
    "maxX" : 1919,
    "minY" : 273,
    "maxY" : 290,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 1867,
        "y" : 290
      },
      "to" : {
        "x" : 1896,
        "y" : 278
      }
    }, {
      "from" : {
        "x" : 1896,
        "y" : 278
      },
      "to" : {
        "x" : 1919,
        "y" : 275
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1913,
        "y" : 280
      },
      "b" : {
        "x" : 1919,
        "y" : 275
      },
      "c" : {
        "x" : 1912,
        "y" : 272
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1912,
        "y" : 272
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1896,
        "y" : 278
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1896,
        "y" : 278
      }
    },
    "inputs" : [ {
      "id" : 5094,
      "points" : [ {
        "x" : 1964,
        "y" : 487
      } ]
    }, {
      "id" : 648,
      "points" : [ {
        "x" : 1791,
        "y" : 336
      } ]
    } ],
    "outputs" : [ {
      "id" : 5043
    } ]
  }, {
    "id" : 5298,
    "reactomeId" : 9657608,
    "displayName" : "Single mechanism MAPK inhibitors bind phosphorylated MAPK",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3274,
      "y" : 348
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 3265,
    "maxX" : 3295,
    "minY" : 330,
    "maxY" : 381,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 3265,
        "y" : 330
      },
      "to" : {
        "x" : 3274,
        "y" : 348
      }
    }, {
      "from" : {
        "x" : 3274,
        "y" : 348
      },
      "to" : {
        "x" : 3295,
        "y" : 381
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3288,
        "y" : 377
      },
      "b" : {
        "x" : 3295,
        "y" : 381
      },
      "c" : {
        "x" : 3295,
        "y" : 373
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3295,
        "y" : 373
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3274,
        "y" : 348
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3274,
        "y" : 348
      }
    },
    "inputs" : [ {
      "id" : 2255,
      "points" : [ {
        "x" : 3260,
        "y" : 297
      } ]
    }, {
      "id" : 5299,
      "points" : [ {
        "x" : 3160,
        "y" : 479
      } ]
    } ],
    "outputs" : [ {
      "id" : 5300
    } ]
  }, {
    "id" : 2227,
    "reactomeId" : 5672960,
    "displayName" : "YWHAB dimer dissociates from dephosphorylated RAF",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1452,
      "y" : 642
    },
    "isFadeOut" : true,
    "minX" : 1432,
    "maxX" : 1472,
    "minY" : 637,
    "maxY" : 647,
    "reactionType" : "Dissociation",
    "segments" : [ {
      "from" : {
        "x" : 1432,
        "y" : 641
      },
      "to" : {
        "x" : 1452,
        "y" : 642
      }
    }, {
      "from" : {
        "x" : 1452,
        "y" : 642
      },
      "to" : {
        "x" : 1472,
        "y" : 643
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1452,
        "y" : 642
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 1452,
        "y" : 642
      }
    },
    "inputs" : [ {
      "id" : 1085
    } ],
    "outputs" : [ {
      "id" : 2268,
      "points" : [ {
        "x" : 1193,
        "y" : 753
      }, {
        "x" : 1411,
        "y" : 749
      } ]
    }, {
      "id" : 2228,
      "points" : [ {
        "x" : 1487,
        "y" : 643
      } ]
    } ]
  }, {
    "id" : 2229,
    "reactomeId" : 5672958,
    "displayName" : "YWHAB dimer dissociates from KSR1:MARK3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1601,
      "y" : 896
    },
    "isFadeOut" : true,
    "minX" : 1580,
    "maxX" : 1633,
    "minY" : 891,
    "maxY" : 901,
    "reactionType" : "Dissociation",
    "segments" : [ {
      "from" : {
        "x" : 1580,
        "y" : 895
      },
      "to" : {
        "x" : 1601,
        "y" : 896
      }
    }, {
      "from" : {
        "x" : 1601,
        "y" : 896
      },
      "to" : {
        "x" : 1633,
        "y" : 891
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1601,
        "y" : 896
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 1601,
        "y" : 896
      }
    },
    "inputs" : [ {
      "id" : 671
    } ],
    "outputs" : [ {
      "id" : 2268,
      "points" : [ {
        "x" : 1193,
        "y" : 763
      }, {
        "x" : 1594,
        "y" : 841
      } ]
    }, {
      "id" : 2230,
      "points" : [ {
        "x" : 1685,
        "y" : 893
      } ]
    } ]
  }, {
    "id" : 2869,
    "reactomeId" : 5674132,
    "displayName" : "WDR83:LAMTOR2:LAMTOR3 binds MAPK components",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2637,
      "y" : 1006
    },
    "isFadeOut" : true,
    "minX" : 2621,
    "maxX" : 2660,
    "minY" : 1001,
    "maxY" : 1011,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 2621,
        "y" : 1006
      },
      "to" : {
        "x" : 2637,
        "y" : 1006
      }
    }, {
      "from" : {
        "x" : 2637,
        "y" : 1006
      },
      "to" : {
        "x" : 2660,
        "y" : 1004
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2653,
        "y" : 1009
      },
      "b" : {
        "x" : 2660,
        "y" : 1004
      },
      "c" : {
        "x" : 2653,
        "y" : 1001
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2653,
        "y" : 1001
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2637,
        "y" : 1006
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2637,
        "y" : 1006
      }
    },
    "inputs" : [ {
      "id" : 2203,
      "points" : [ {
        "x" : 2455,
        "y" : 624
      } ]
    }, {
      "id" : 2204,
      "points" : [ {
        "x" : 2333,
        "y" : 587
      } ]
    }, {
      "id" : 2870,
      "points" : [ {
        "x" : 2573,
        "y" : 1007
      } ]
    }, {
      "id" : 2871,
      "points" : [ {
        "x" : 2652,
        "y" : 932
      } ]
    } ],
    "outputs" : [ {
      "id" : 2874
    } ]
  }, {
    "id" : 313,
    "reactomeId" : 5658435,
    "displayName" : "RAS GAPs bind RAS:GTP",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 616,
      "y" : 815
    },
    "isFadeOut" : true,
    "minX" : 550,
    "maxX" : 630,
    "minY" : 717,
    "maxY" : 855,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 630,
        "y" : 717
      },
      "to" : {
        "x" : 616,
        "y" : 815
      }
    }, {
      "from" : {
        "x" : 616,
        "y" : 815
      },
      "to" : {
        "x" : 550,
        "y" : 855
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 554,
        "y" : 848
      },
      "b" : {
        "x" : 550,
        "y" : 855
      },
      "c" : {
        "x" : 558,
        "y" : 855
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 558,
        "y" : 855
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 616,
        "y" : 815
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 616,
        "y" : 815
      }
    },
    "inputs" : [ {
      "id" : 308,
      "points" : [ {
        "x" : 583,
        "y" : 396
      } ]
    }, {
      "id" : 314,
      "points" : [ {
        "x" : 597,
        "y" : 705
      } ]
    } ],
    "outputs" : [ {
      "id" : 315
    } ]
  }, {
    "id" : 3003,
    "reactomeId" : 5674387,
    "displayName" : "Phosphorylated MAPKs translocate into the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4006,
      "y" : 1037
    },
    "isFadeOut" : true,
    "minX" : 3969,
    "maxX" : 4012,
    "minY" : 938,
    "maxY" : 1104,
    "reactionType" : "Omitted Process",
    "segments" : [ {
      "from" : {
        "x" : 3969,
        "y" : 938
      },
      "to" : {
        "x" : 4006,
        "y" : 1037
      }
    }, {
      "from" : {
        "x" : 4006,
        "y" : 1037
      },
      "to" : {
        "x" : 4003,
        "y" : 1104
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3999,
        "y" : 1097
      },
      "b" : {
        "x" : 4003,
        "y" : 1104
      },
      "c" : {
        "x" : 4007,
        "y" : 1097
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4007,
        "y" : 1097
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 4000,
        "y" : 1031
      },
      "b" : {
        "x" : 4012,
        "y" : 1043
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4006,
        "y" : 1037
      }
    },
    "inputs" : [ {
      "id" : 3004
    } ],
    "outputs" : [ {
      "id" : 3007
    } ],
    "inhibitors" : [ {
      "id" : 3104,
      "points" : [ {
        "x" : 4183,
        "y" : 948
      } ]
    } ]
  }, {
    "id" : 316,
    "reactomeId" : 5658231,
    "displayName" : "RAS GAPs stimulate RAS GTPase activity",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 487,
      "y" : 794
    },
    "isFadeOut" : true,
    "minX" : 476,
    "maxX" : 508,
    "minY" : 759,
    "maxY" : 855,
    "segments" : [ {
      "from" : {
        "x" : 508,
        "y" : 855
      },
      "to" : {
        "x" : 487,
        "y" : 794
      }
    }, {
      "from" : {
        "x" : 487,
        "y" : 794
      },
      "to" : {
        "x" : 476,
        "y" : 759
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 481,
        "y" : 788
      },
      "b" : {
        "x" : 493,
        "y" : 800
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 487,
        "y" : 794
      }
    },
    "inputs" : [ {
      "id" : 315
    } ],
    "outputs" : [ {
      "id" : 314,
      "points" : [ {
        "x" : 561,
        "y" : 705
      }, {
        "x" : 513,
        "y" : 757
      } ]
    }, {
      "id" : 307,
      "points" : [ {
        "x" : 445,
        "y" : 746
      } ]
    } ],
    "catalysts" : [ {
      "id" : 315,
      "points" : [ {
        "x" : 528,
        "y" : 855
      }, {
        "x" : 564,
        "y" : 792
      } ]
    } ]
  }, {
    "id" : 318,
    "reactomeId" : 5658438,
    "displayName" : "SPRED dimer binds NF1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 669,
      "y" : 924
    },
    "isFadeOut" : true,
    "minX" : 644,
    "maxX" : 703,
    "minY" : 908,
    "maxY" : 939,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 703,
        "y" : 908
      },
      "to" : {
        "x" : 669,
        "y" : 924
      }
    }, {
      "from" : {
        "x" : 669,
        "y" : 924
      },
      "to" : {
        "x" : 644,
        "y" : 939
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 648,
        "y" : 932
      },
      "b" : {
        "x" : 644,
        "y" : 939
      },
      "c" : {
        "x" : 652,
        "y" : 939
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 652,
        "y" : 939
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 669,
        "y" : 924
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 669,
        "y" : 924
      }
    },
    "inputs" : [ {
      "id" : 319,
      "points" : [ {
        "x" : 735,
        "y" : 913
      } ]
    }, {
      "id" : 320,
      "points" : [ {
        "x" : 697,
        "y" : 886
      } ]
    } ],
    "outputs" : [ {
      "id" : 317
    } ]
  }, {
    "id" : 4161,
    "reactomeId" : 8867654,
    "displayName" : "PTPN3 binds p-T183,Y185 MAPK12",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3085,
      "y" : 1409
    },
    "isFadeOut" : true,
    "minX" : 3040,
    "maxX" : 3127,
    "minY" : 1404,
    "maxY" : 1414,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 3040,
        "y" : 1409
      },
      "to" : {
        "x" : 3085,
        "y" : 1409
      }
    }, {
      "from" : {
        "x" : 3085,
        "y" : 1409
      },
      "to" : {
        "x" : 3127,
        "y" : 1408
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3120,
        "y" : 1412
      },
      "b" : {
        "x" : 3127,
        "y" : 1408
      },
      "c" : {
        "x" : 3120,
        "y" : 1404
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3120,
        "y" : 1404
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3085,
        "y" : 1409
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3085,
        "y" : 1409
      }
    },
    "inputs" : [ {
      "id" : 4162,
      "points" : [ {
        "x" : 2975,
        "y" : 1409
      } ]
    }, {
      "id" : 4163,
      "points" : [ {
        "x" : 3016,
        "y" : 1325
      } ]
    } ],
    "outputs" : [ {
      "id" : 4164
    } ]
  }, {
    "id" : 322,
    "reactomeId" : 5658424,
    "displayName" : "KBTBD7:CUL3:RBX1 ubiquitinates NF1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 606,
      "y" : 1040
    },
    "isFadeOut" : true,
    "minX" : 600,
    "maxX" : 614,
    "minY" : 1018,
    "maxY" : 1087,
    "segments" : [ {
      "from" : {
        "x" : 614,
        "y" : 1018
      },
      "to" : {
        "x" : 606,
        "y" : 1040
      }
    }, {
      "from" : {
        "x" : 606,
        "y" : 1040
      },
      "to" : {
        "x" : 608,
        "y" : 1087
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 604,
        "y" : 1080
      },
      "b" : {
        "x" : 608,
        "y" : 1087
      },
      "c" : {
        "x" : 612,
        "y" : 1080
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 612,
        "y" : 1080
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 600,
        "y" : 1034
      },
      "b" : {
        "x" : 612,
        "y" : 1046
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 606,
        "y" : 1040
      }
    },
    "inputs" : [ {
      "id" : 323,
      "points" : [ {
        "x" : 654,
        "y" : 1020
      } ]
    }, {
      "id" : 317,
      "points" : [ {
        "x" : 614,
        "y" : 989
      } ]
    } ],
    "outputs" : [ {
      "id" : 324
    } ],
    "catalysts" : [ {
      "id" : 325,
      "points" : [ {
        "x" : 574,
        "y" : 1043
      } ]
    } ]
  }, {
    "id" : 2883,
    "reactomeId" : 5674130,
    "displayName" : "MAP2Ks and MAPKs are phosphorylated at the endosome membrane",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2849,
      "y" : 1004
    },
    "isFadeOut" : true,
    "minX" : 2822,
    "maxX" : 2880,
    "minY" : 998,
    "maxY" : 1010,
    "reactionType" : "Omitted Process",
    "segments" : [ {
      "from" : {
        "x" : 2822,
        "y" : 1003
      },
      "to" : {
        "x" : 2849,
        "y" : 1004
      }
    }, {
      "from" : {
        "x" : 2849,
        "y" : 1004
      },
      "to" : {
        "x" : 2880,
        "y" : 1003
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2843,
        "y" : 998
      },
      "b" : {
        "x" : 2855,
        "y" : 1010
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2849,
        "y" : 1004
      }
    },
    "inputs" : [ {
      "id" : 2884,
      "points" : [ {
        "x" : 2816,
        "y" : 959
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 2874,
      "points" : [ {
        "x" : 2792,
        "y" : 1002
      } ]
    } ],
    "outputs" : [ {
      "id" : 2885,
      "points" : [ {
        "x" : 2910,
        "y" : 1001
      } ]
    }, {
      "id" : 2886,
      "points" : [ {
        "x" : 2892,
        "y" : 957
      } ],
      "stoichiometry" : 4
    } ]
  }, {
    "id" : 4805,
    "reactomeId" : 9635743,
    "displayName" : "PTPN7 binds p-T,Y-MAPK",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3668,
      "y" : 734
    },
    "isFadeOut" : true,
    "minX" : 3630,
    "maxX" : 3678,
    "minY" : 669,
    "maxY" : 739,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 3630,
        "y" : 738
      },
      "to" : {
        "x" : 3668,
        "y" : 734
      }
    }, {
      "from" : {
        "x" : 3668,
        "y" : 734
      },
      "to" : {
        "x" : 3678,
        "y" : 669
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3681,
        "y" : 676
      },
      "b" : {
        "x" : 3678,
        "y" : 669
      },
      "c" : {
        "x" : 3673,
        "y" : 675
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3673,
        "y" : 675
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3668,
        "y" : 734
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3668,
        "y" : 734
      }
    },
    "inputs" : [ {
      "id" : 4806,
      "points" : [ {
        "x" : 3518,
        "y" : 800
      } ]
    }, {
      "id" : 3008,
      "points" : [ {
        "x" : 3575,
        "y" : 734
      } ]
    } ],
    "outputs" : [ {
      "id" : 4807
    } ]
  }, {
    "id" : 4165,
    "reactomeId" : 8867658,
    "displayName" : "PTPN3 dephosphorylates MAPK12",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3325,
      "y" : 1405
    },
    "isFadeOut" : true,
    "minX" : 3291,
    "maxX" : 3364,
    "minY" : 1399,
    "maxY" : 1411,
    "segments" : [ {
      "from" : {
        "x" : 3291,
        "y" : 1404
      },
      "to" : {
        "x" : 3325,
        "y" : 1405
      }
    }, {
      "from" : {
        "x" : 3325,
        "y" : 1405
      },
      "to" : {
        "x" : 3364,
        "y" : 1405
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3319,
        "y" : 1399
      },
      "b" : {
        "x" : 3331,
        "y" : 1411
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3325,
        "y" : 1405
      }
    },
    "inputs" : [ {
      "id" : 4164,
      "points" : [ {
        "x" : 3236,
        "y" : 1405
      } ]
    }, {
      "id" : 4166,
      "points" : [ {
        "x" : 3258,
        "y" : 1363
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 4167,
      "points" : [ {
        "x" : 3421,
        "y" : 1399
      } ]
    }, {
      "id" : 4163,
      "points" : [ {
        "x" : 3040,
        "y" : 1310
      }, {
        "x" : 3319,
        "y" : 1308
      } ]
    }, {
      "id" : 4169,
      "points" : [ {
        "x" : 3397,
        "y" : 1348
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 4164,
      "points" : [ {
        "x" : 3236,
        "y" : 1421
      }, {
        "x" : 3301,
        "y" : 1440
      } ]
    } ]
  }, {
    "id" : 326,
    "reactomeId" : 5658430,
    "displayName" : "NF1 is degraded by the proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 716,
      "y" : 1089
    },
    "isFadeOut" : true,
    "minX" : 668,
    "maxX" : 764,
    "minY" : 947,
    "maxY" : 1098,
    "reactionType" : "Omitted Process",
    "segments" : [ {
      "from" : {
        "x" : 668,
        "y" : 1098
      },
      "to" : {
        "x" : 716,
        "y" : 1089
      }
    }, {
      "from" : {
        "x" : 716,
        "y" : 1089
      },
      "to" : {
        "x" : 764,
        "y" : 947
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 766,
        "y" : 955
      },
      "b" : {
        "x" : 764,
        "y" : 947
      },
      "c" : {
        "x" : 758,
        "y" : 952
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 758,
        "y" : 952
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 710,
        "y" : 1083
      },
      "b" : {
        "x" : 722,
        "y" : 1095
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 716,
        "y" : 1089
      }
    },
    "inputs" : [ {
      "id" : 324
    } ],
    "outputs" : [ {
      "id" : 319
    } ],
    "catalysts" : [ {
      "id" : 327,
      "points" : [ {
        "x" : 712,
        "y" : 1152
      } ]
    } ]
  }, {
    "id" : 4170,
    "reactomeId" : 8868118,
    "displayName" : "MAPK12 phosphorylates PTPN3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3256,
      "y" : 1501
    },
    "isFadeOut" : true,
    "minX" : 3205,
    "maxX" : 3293,
    "minY" : 1495,
    "maxY" : 1507,
    "segments" : [ {
      "from" : {
        "x" : 3205,
        "y" : 1497
      },
      "to" : {
        "x" : 3256,
        "y" : 1501
      }
    }, {
      "from" : {
        "x" : 3256,
        "y" : 1501
      },
      "to" : {
        "x" : 3293,
        "y" : 1504
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3250,
        "y" : 1495
      },
      "b" : {
        "x" : 3262,
        "y" : 1507
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3256,
        "y" : 1501
      }
    },
    "inputs" : [ {
      "id" : 4164,
      "points" : [ {
        "x" : 3185,
        "y" : 1428
      } ]
    }, {
      "id" : 4171,
      "points" : [ {
        "x" : 3178,
        "y" : 1525
      } ]
    } ],
    "outputs" : [ {
      "id" : 4172,
      "points" : [ {
        "x" : 3315,
        "y" : 1532
      } ]
    }, {
      "id" : 4173,
      "points" : [ {
        "x" : 3393,
        "y" : 1504
      } ]
    } ],
    "catalysts" : [ {
      "id" : 4164,
      "points" : [ {
        "x" : 3213,
        "y" : 1428
      }, {
        "x" : 3264,
        "y" : 1453
      } ]
    } ]
  }, {
    "id" : 2253,
    "reactomeId" : 5672973,
    "displayName" : "MAP2Ks phosphorylate MAPKs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2993,
      "y" : 290
    },
    "isFadeOut" : true,
    "minX" : 2946,
    "maxX" : 3036,
    "minY" : 271,
    "maxY" : 296,
    "segments" : [ {
      "from" : {
        "x" : 2946,
        "y" : 271
      },
      "to" : {
        "x" : 2993,
        "y" : 290
      }
    }, {
      "from" : {
        "x" : 2993,
        "y" : 290
      },
      "to" : {
        "x" : 3036,
        "y" : 281
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2987,
        "y" : 284
      },
      "b" : {
        "x" : 2999,
        "y" : 296
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2993,
        "y" : 290
      }
    },
    "inputs" : [ {
      "id" : 2211,
      "points" : [ {
        "x" : 2845,
        "y" : 245
      } ]
    }, {
      "id" : 2254,
      "points" : [ {
        "x" : 2920,
        "y" : 245
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 2255,
      "points" : [ {
        "x" : 3186,
        "y" : 268
      } ]
    }, {
      "id" : 2256,
      "points" : [ {
        "x" : 3073,
        "y" : 233
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 2211,
      "points" : [ {
        "x" : 2845,
        "y" : 206
      }, {
        "x" : 2946,
        "y" : 173
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 5209,
      "points" : [ {
        "x" : 2929,
        "y" : 363
      } ]
    }, {
      "id" : 5210,
      "points" : [ {
        "x" : 2760,
        "y" : 396
      } ]
    }, {
      "id" : 5289,
      "points" : [ {
        "x" : 3075,
        "y" : 349
      } ]
    } ]
  }, {
    "id" : 2263,
    "reactomeId" : 5672980,
    "displayName" : "Dissociation of RAS:RAF complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3462,
      "y" : 288
    },
    "isFadeOut" : true,
    "minX" : 3329,
    "maxX" : 3511,
    "minY" : 271,
    "maxY" : 354,
    "reactionType" : "Dissociation",
    "segments" : [ {
      "from" : {
        "x" : 3329,
        "y" : 271
      },
      "to" : {
        "x" : 3462,
        "y" : 288
      }
    }, {
      "from" : {
        "x" : 3462,
        "y" : 288
      },
      "to" : {
        "x" : 3511,
        "y" : 354
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 3462,
        "y" : 288
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 3462,
        "y" : 288
      }
    },
    "inputs" : [ {
      "id" : 2255
    } ],
    "outputs" : [ {
      "id" : 2264,
      "points" : [ {
        "x" : 3563,
        "y" : 354
      } ]
    }, {
      "id" : 2265,
      "points" : [ {
        "x" : 3505,
        "y" : 602
      } ]
    }, {
      "id" : 2266,
      "points" : [ {
        "x" : 3165,
        "y" : 933
      } ]
    }, {
      "id" : 2205,
      "points" : [ {
        "x" : 2160,
        "y" : 778
      }, {
        "x" : 3204,
        "y" : 788
      } ]
    } ]
  }, {
    "id" : 5211,
    "reactomeId" : 9657599,
    "displayName" : "Dual mechanism MAP2K inhibitors bind MAP2Ks",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2590,
      "y" : 442
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 2571,
    "maxX" : 2626,
    "minY" : 435,
    "maxY" : 447,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 2571,
        "y" : 442
      },
      "to" : {
        "x" : 2590,
        "y" : 442
      }
    }, {
      "from" : {
        "x" : 2590,
        "y" : 442
      },
      "to" : {
        "x" : 2626,
        "y" : 435
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2620,
        "y" : 440
      },
      "b" : {
        "x" : 2626,
        "y" : 435
      },
      "c" : {
        "x" : 2618,
        "y" : 432
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2618,
        "y" : 432
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2590,
        "y" : 442
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2590,
        "y" : 442
      }
    },
    "inputs" : [ {
      "id" : 5212,
      "points" : [ {
        "x" : 2526,
        "y" : 475
      } ]
    }, {
      "id" : 2206,
      "points" : [ {
        "x" : 2542,
        "y" : 409
      } ]
    } ],
    "outputs" : [ {
      "id" : 5210
    } ]
  }, {
    "id" : 5213,
    "reactomeId" : 9657606,
    "displayName" : "Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2805,
      "y" : 447
    },
    "isDisease" : true,
    "isFadeOut" : true,
    "minX" : 2783,
    "maxX" : 2824,
    "minY" : 436,
    "maxY" : 455,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 2783,
        "y" : 455
      },
      "to" : {
        "x" : 2805,
        "y" : 447
      }
    }, {
      "from" : {
        "x" : 2805,
        "y" : 447
      },
      "to" : {
        "x" : 2824,
        "y" : 436
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2820,
        "y" : 443
      },
      "b" : {
        "x" : 2824,
        "y" : 436
      },
      "c" : {
        "x" : 2816,
        "y" : 436
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2816,
        "y" : 436
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2805,
        "y" : 447
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2805,
        "y" : 447
      }
    },
    "inputs" : [ {
      "id" : 5214,
      "points" : [ {
        "x" : 2746,
        "y" : 475
      } ]
    }, {
      "id" : 2211,
      "points" : [ {
        "x" : 2774,
        "y" : 263
      } ]
    } ],
    "outputs" : [ {
      "id" : 5209
    } ]
  }, {
    "id" : 3038,
    "reactomeId" : 5674496,
    "displayName" : "Activated MAPKs phosphorylate MAP2K1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3562,
      "y" : 1086
    },
    "isFadeOut" : true,
    "minX" : 3556,
    "maxX" : 3568,
    "minY" : 1063,
    "maxY" : 1105,
    "segments" : [ {
      "from" : {
        "x" : 3558,
        "y" : 1063
      },
      "to" : {
        "x" : 3562,
        "y" : 1086
      }
    }, {
      "from" : {
        "x" : 3562,
        "y" : 1086
      },
      "to" : {
        "x" : 3561,
        "y" : 1105
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3556,
        "y" : 1080
      },
      "b" : {
        "x" : 3568,
        "y" : 1092
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3562,
        "y" : 1086
      }
    },
    "inputs" : [ {
      "id" : 3039,
      "points" : [ {
        "x" : 3556,
        "y" : 1022
      } ]
    }, {
      "id" : 3041,
      "points" : [ {
        "x" : 3532,
        "y" : 1054
      } ]
    } ],
    "outputs" : [ {
      "id" : 3042,
      "points" : [ {
        "x" : 3563,
        "y" : 1129
      } ]
    }, {
      "id" : 3043,
      "points" : [ {
        "x" : 3532,
        "y" : 1110
      } ]
    } ],
    "catalysts" : [ {
      "id" : 3004,
      "points" : [ {
        "x" : 3904,
        "y" : 929
      } ]
    } ]
  }, {
    "id" : 2911,
    "reactomeId" : 5674140,
    "displayName" : "PAQR3 binds inactive RAFs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1537,
      "y" : 1373
    },
    "isFadeOut" : true,
    "minX" : 1532,
    "maxX" : 1542,
    "minY" : 1330,
    "maxY" : 1398,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 1538,
        "y" : 1398
      },
      "to" : {
        "x" : 1537,
        "y" : 1373
      }
    }, {
      "from" : {
        "x" : 1537,
        "y" : 1373
      },
      "to" : {
        "x" : 1537,
        "y" : 1330
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1541,
        "y" : 1337
      },
      "b" : {
        "x" : 1537,
        "y" : 1330
      },
      "c" : {
        "x" : 1533,
        "y" : 1337
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1533,
        "y" : 1337
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1537,
        "y" : 1373
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1537,
        "y" : 1373
      }
    },
    "inputs" : [ {
      "id" : 386,
      "points" : [ {
        "x" : 900,
        "y" : 654
      }, {
        "x" : 966,
        "y" : 1323
      } ]
    }, {
      "id" : 2912,
      "points" : [ {
        "x" : 1538,
        "y" : 1423
      } ]
    } ],
    "outputs" : [ {
      "id" : 2913
    } ]
  }, {
    "id" : 351,
    "reactomeId" : 5672961,
    "displayName" : "PP2A dephosphorylates inactive RAFs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1199,
      "y" : 639
    },
    "isFadeOut" : true,
    "minX" : 1170,
    "maxX" : 1222,
    "minY" : 633,
    "maxY" : 645,
    "segments" : [ {
      "from" : {
        "x" : 1170,
        "y" : 639
      },
      "to" : {
        "x" : 1199,
        "y" : 639
      }
    }, {
      "from" : {
        "x" : 1199,
        "y" : 639
      },
      "to" : {
        "x" : 1222,
        "y" : 637
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1193,
        "y" : 633
      },
      "b" : {
        "x" : 1205,
        "y" : 645
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1199,
        "y" : 639
      }
    },
    "inputs" : [ {
      "id" : 353,
      "points" : [ {
        "x" : 1135,
        "y" : 671
      } ]
    }, {
      "id" : 1081,
      "points" : [ {
        "x" : 1151,
        "y" : 637
      } ]
    } ],
    "outputs" : [ {
      "id" : 355,
      "points" : [ {
        "x" : 1259,
        "y" : 673
      } ]
    }, {
      "id" : 1085,
      "points" : [ {
        "x" : 1277,
        "y" : 637
      } ]
    } ],
    "catalysts" : [ {
      "id" : 356,
      "points" : [ {
        "x" : 1203,
        "y" : 688
      } ]
    } ]
  }, {
    "id" : 2273,
    "reactomeId" : 5674018,
    "displayName" : "BRAP binds RAS:GTP",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 827,
      "y" : 409
    },
    "isFadeOut" : true,
    "minX" : 795,
    "maxX" : 855,
    "minY" : 404,
    "maxY" : 434,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 795,
        "y" : 409
      },
      "to" : {
        "x" : 827,
        "y" : 409
      }
    }, {
      "from" : {
        "x" : 827,
        "y" : 409
      },
      "to" : {
        "x" : 855,
        "y" : 434
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 847,
        "y" : 432
      },
      "b" : {
        "x" : 855,
        "y" : 434
      },
      "c" : {
        "x" : 852,
        "y" : 426
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 852,
        "y" : 426
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 827,
        "y" : 409
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 827,
        "y" : 409
      }
    },
    "inputs" : [ {
      "id" : 2274,
      "points" : [ {
        "x" : 818,
        "y" : 494
      } ]
    }, {
      "id" : 308,
      "points" : [ {
        "x" : 622,
        "y" : 380
      } ]
    } ],
    "outputs" : [ {
      "id" : 2275
    } ]
  }, {
    "id" : 2276,
    "reactomeId" : 5674022,
    "displayName" : "BRAP autoubiquitinates",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 970,
      "y" : 460
    },
    "isFadeOut" : true,
    "minX" : 946,
    "maxX" : 994,
    "minY" : 454,
    "maxY" : 466,
    "segments" : [ {
      "from" : {
        "x" : 946,
        "y" : 461
      },
      "to" : {
        "x" : 970,
        "y" : 460
      }
    }, {
      "from" : {
        "x" : 970,
        "y" : 460
      },
      "to" : {
        "x" : 994,
        "y" : 460
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 987,
        "y" : 464
      },
      "b" : {
        "x" : 994,
        "y" : 460
      },
      "c" : {
        "x" : 987,
        "y" : 456
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 987,
        "y" : 456
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 964,
        "y" : 454
      },
      "b" : {
        "x" : 976,
        "y" : 466
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 970,
        "y" : 460
      }
    },
    "inputs" : [ {
      "id" : 2275,
      "points" : [ {
        "x" : 928,
        "y" : 460
      } ]
    }, {
      "id" : 2279,
      "points" : [ {
        "x" : 928,
        "y" : 492
      } ]
    } ],
    "outputs" : [ {
      "id" : 2277
    } ],
    "catalysts" : [ {
      "id" : 2275,
      "points" : [ {
        "x" : 921,
        "y" : 434
      }, {
        "x" : 948,
        "y" : 423
      } ]
    } ]
  }, {
    "id" : 357,
    "reactomeId" : 5672950,
    "displayName" : "\"Activator\" RAF:YWHAB dimer binds RAS:GTP",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1398,
      "y" : 376
    },
    "isFadeOut" : true,
    "minX" : 1348,
    "maxX" : 1442,
    "minY" : 371,
    "maxY" : 381,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 1348,
        "y" : 379
      },
      "to" : {
        "x" : 1398,
        "y" : 376
      }
    }, {
      "from" : {
        "x" : 1398,
        "y" : 376
      },
      "to" : {
        "x" : 1442,
        "y" : 376
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1435,
        "y" : 380
      },
      "b" : {
        "x" : 1442,
        "y" : 376
      },
      "c" : {
        "x" : 1435,
        "y" : 372
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1435,
        "y" : 372
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1398,
        "y" : 376
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1398,
        "y" : 376
      }
    },
    "inputs" : [ {
      "id" : 1079,
      "points" : [ {
        "x" : 1298,
        "y" : 482
      } ]
    }, {
      "id" : 308,
      "points" : [ {
        "x" : 622,
        "y" : 374
      } ]
    } ],
    "outputs" : [ {
      "id" : 359
    } ],
    "activators" : [ {
      "id" : 2842,
      "points" : [ {
        "x" : 1397,
        "y" : 500
      } ]
    } ]
  }, {
    "id" : 165482,
    "reactomeId" : 6802927,
    "displayName" : "BRAF and RAF fusion mutant dimers are phosphorylated",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2053,
      "y" : 383
    },
    "isDisease" : true,
    "minX" : 1981,
    "maxX" : 2078,
    "minY" : 377,
    "maxY" : 389,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1981,
        "y" : 380
      },
      "to" : {
        "x" : 2053,
        "y" : 383
      }
    }, {
      "from" : {
        "x" : 2053,
        "y" : 383
      },
      "to" : {
        "x" : 2078,
        "y" : 381
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2047,
        "y" : 377
      },
      "b" : {
        "x" : 2059,
        "y" : 389
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2053,
        "y" : 383
      }
    },
    "inputs" : [ {
      "id" : 165483,
      "points" : [ {
        "x" : 1816,
        "y" : 375
      } ]
    }, {
      "id" : 819,
      "points" : [ {
        "x" : 1947,
        "y" : 350
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 820,
      "points" : [ {
        "x" : 2107,
        "y" : 329
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 165484,
      "points" : [ {
        "x" : 2107,
        "y" : 383
      } ]
    } ],
    "catalysts" : [ {
      "id" : 1061,
      "points" : [ {
        "x" : 2092,
        "y" : 508
      } ]
    } ]
  }, {
    "id" : 364,
    "reactomeId" : 5672951,
    "displayName" : "Inactive RAFs bind YWHAB",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 997,
      "y" : 627
    },
    "isFadeOut" : true,
    "minX" : 971,
    "maxX" : 1027,
    "minY" : 622,
    "maxY" : 632,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 971,
        "y" : 627
      },
      "to" : {
        "x" : 997,
        "y" : 627
      }
    }, {
      "from" : {
        "x" : 997,
        "y" : 627
      },
      "to" : {
        "x" : 1027,
        "y" : 628
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1020,
        "y" : 632
      },
      "b" : {
        "x" : 1027,
        "y" : 628
      },
      "c" : {
        "x" : 1020,
        "y" : 624
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1020,
        "y" : 624
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 997,
        "y" : 627
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 997,
        "y" : 627
      }
    },
    "inputs" : [ {
      "id" : 386,
      "points" : [ {
        "x" : 952,
        "y" : 627
      } ]
    }, {
      "id" : 2268,
      "points" : [ {
        "x" : 1129,
        "y" : 741
      } ]
    } ],
    "outputs" : [ {
      "id" : 1081
    } ]
  }, {
    "id" : 2284,
    "reactomeId" : 5674019,
    "displayName" : "BRAP binds KSR1:MARK3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 896,
      "y" : 980
    },
    "isFadeOut" : true,
    "minX" : 875,
    "maxX" : 1116,
    "minY" : 845,
    "maxY" : 985,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 875,
        "y" : 845
      },
      "to" : {
        "x" : 896,
        "y" : 980
      }
    }, {
      "from" : {
        "x" : 896,
        "y" : 980
      },
      "to" : {
        "x" : 1116,
        "y" : 982
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1109,
        "y" : 986
      },
      "b" : {
        "x" : 1116,
        "y" : 982
      },
      "c" : {
        "x" : 1109,
        "y" : 978
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1109,
        "y" : 978
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 896,
        "y" : 980
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 896,
        "y" : 980
      }
    },
    "inputs" : [ {
      "id" : 660,
      "points" : [ {
        "x" : 932,
        "y" : 827
      } ]
    }, {
      "id" : 2274,
      "points" : [ {
        "x" : 824,
        "y" : 528
      } ]
    } ],
    "outputs" : [ {
      "id" : 2285
    } ]
  }, {
    "id" : 165485,
    "reactomeId" : 6802935,
    "displayName" : "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2993,
      "y" : 290
    },
    "isDisease" : true,
    "minX" : 2946,
    "maxX" : 3036,
    "minY" : 271,
    "maxY" : 296,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2946,
        "y" : 271
      },
      "to" : {
        "x" : 2993,
        "y" : 290
      }
    }, {
      "from" : {
        "x" : 2993,
        "y" : 290
      },
      "to" : {
        "x" : 3036,
        "y" : 281
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2987,
        "y" : 284
      },
      "b" : {
        "x" : 2999,
        "y" : 296
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2993,
        "y" : 290
      }
    },
    "inputs" : [ {
      "id" : 165486,
      "points" : [ {
        "x" : 2845,
        "y" : 245
      } ]
    }, {
      "id" : 2254,
      "points" : [ {
        "x" : 2920,
        "y" : 245
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 165487,
      "points" : [ {
        "x" : 3186,
        "y" : 268
      } ]
    }, {
      "id" : 2256,
      "points" : [ {
        "x" : 3073,
        "y" : 233
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 165486,
      "points" : [ {
        "x" : 2845,
        "y" : 206
      }, {
        "x" : 2946,
        "y" : 173
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 5209,
      "points" : [ {
        "x" : 2929,
        "y" : 363
      } ]
    }, {
      "id" : 5210,
      "points" : [ {
        "x" : 2760,
        "y" : 396
      } ]
    }, {
      "id" : 5289,
      "points" : [ {
        "x" : 3075,
        "y" : 349
      } ]
    } ]
  }, {
    "id" : 165490,
    "reactomeId" : 6802933,
    "displayName" : "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2628,
      "y" : 342
    },
    "isDisease" : true,
    "minX" : 2599,
    "maxX" : 2673,
    "minY" : 306,
    "maxY" : 348,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2599,
        "y" : 348
      },
      "to" : {
        "x" : 2628,
        "y" : 342
      }
    }, {
      "from" : {
        "x" : 2628,
        "y" : 342
      },
      "to" : {
        "x" : 2673,
        "y" : 306
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2622,
        "y" : 336
      },
      "b" : {
        "x" : 2634,
        "y" : 348
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2628,
        "y" : 342
      }
    },
    "inputs" : [ {
      "id" : 5301,
      "points" : [ {
        "x" : 2586,
        "y" : 325
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 165489,
      "points" : [ {
        "x" : 2570,
        "y" : 358
      } ]
    } ],
    "outputs" : [ {
      "id" : 165486,
      "points" : [ {
        "x" : 2731,
        "y" : 263
      } ]
    }, {
      "id" : 2212,
      "points" : [ {
        "x" : 2719,
        "y" : 321
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 165489,
      "points" : [ {
        "x" : 2570,
        "y" : 380
      }, {
        "x" : 2589,
        "y" : 383
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 5043,
      "points" : [ {
        "x" : 2049,
        "y" : 229
      }, {
        "x" : 2182,
        "y" : 134
      }, {
        "x" : 2670,
        "y" : 137
      } ]
    }, {
      "id" : 5210,
      "points" : [ {
        "x" : 2662,
        "y" : 383
      } ]
    } ]
  }, {
    "id" : 165491,
    "reactomeId" : 6802932,
    "displayName" : "Dissociation of BRAF/RAF fusion complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3462,
      "y" : 288
    },
    "isDisease" : true,
    "minX" : 3329,
    "maxX" : 3511,
    "minY" : 271,
    "maxY" : 354,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 3329,
        "y" : 271
      },
      "to" : {
        "x" : 3462,
        "y" : 288
      }
    }, {
      "from" : {
        "x" : 3462,
        "y" : 288
      },
      "to" : {
        "x" : 3511,
        "y" : 354
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 3462,
        "y" : 288
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 3462,
        "y" : 288
      }
    },
    "inputs" : [ {
      "id" : 165487
    } ],
    "outputs" : [ {
      "id" : 165492,
      "points" : [ {
        "x" : 3560,
        "y" : 354
      } ]
    }, {
      "id" : 2265,
      "points" : [ {
        "x" : 3505,
        "y" : 602
      } ]
    }, {
      "id" : 2266,
      "points" : [ {
        "x" : 3165,
        "y" : 933
      } ]
    }, {
      "id" : 2205,
      "points" : [ {
        "x" : 2160,
        "y" : 778
      }, {
        "x" : 3204,
        "y" : 788
      } ]
    } ]
  }, {
    "id" : 165488,
    "reactomeId" : 6802934,
    "displayName" : "p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2422,
      "y" : 379
    },
    "isDisease" : true,
    "minX" : 2316,
    "maxX" : 2466,
    "minY" : 374,
    "maxY" : 384,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2316,
        "y" : 379
      },
      "to" : {
        "x" : 2422,
        "y" : 379
      }
    }, {
      "from" : {
        "x" : 2422,
        "y" : 379
      },
      "to" : {
        "x" : 2466,
        "y" : 377
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2459,
        "y" : 381
      },
      "b" : {
        "x" : 2466,
        "y" : 377
      },
      "c" : {
        "x" : 2459,
        "y" : 373
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2459,
        "y" : 373
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2422,
        "y" : 379
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2422,
        "y" : 379
      }
    },
    "inputs" : [ {
      "id" : 2203,
      "points" : [ {
        "x" : 2444,
        "y" : 590
      } ]
    }, {
      "id" : 165484,
      "points" : [ {
        "x" : 2239,
        "y" : 384
      } ]
    }, {
      "id" : 2204,
      "points" : [ {
        "x" : 2316,
        "y" : 525
      } ]
    }, {
      "id" : 2205,
      "points" : [ {
        "x" : 2095,
        "y" : 761
      } ]
    } ],
    "outputs" : [ {
      "id" : 165489
    } ],
    "inhibitors" : [ {
      "id" : 3453,
      "points" : [ {
        "x" : 2493,
        "y" : 262
      } ]
    } ]
  }, {
    "id" : 2934,
    "reactomeId" : 5674366,
    "displayName" : "IL17RD binds p-2S MAP2Ks and MAPKs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1770,
      "y" : 1401
    },
    "isFadeOut" : true,
    "minX" : 1762,
    "maxX" : 1775,
    "minY" : 1367,
    "maxY" : 1434,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 1771,
        "y" : 1434
      },
      "to" : {
        "x" : 1770,
        "y" : 1401
      }
    }, {
      "from" : {
        "x" : 1770,
        "y" : 1401
      },
      "to" : {
        "x" : 1762,
        "y" : 1367
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1767,
        "y" : 1373
      },
      "b" : {
        "x" : 1762,
        "y" : 1367
      },
      "c" : {
        "x" : 1760,
        "y" : 1375
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1760,
        "y" : 1375
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1770,
        "y" : 1401
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1770,
        "y" : 1401
      }
    },
    "inputs" : [ {
      "id" : 2203,
      "points" : [ {
        "x" : 2441,
        "y" : 624
      } ]
    }, {
      "id" : 2266,
      "points" : [ {
        "x" : 3145,
        "y" : 995
      }, {
        "x" : 3119,
        "y" : 1111
      }, {
        "x" : 2385,
        "y" : 1310
      } ]
    }, {
      "id" : 2935,
      "points" : [ {
        "x" : 1767,
        "y" : 1464
      } ]
    } ],
    "outputs" : [ {
      "id" : 2936
    } ]
  }, {
    "id" : 2937,
    "reactomeId" : 5674373,
    "displayName" : "MAP2Ks phosphorylate MAPK at the Golgi membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1773,
      "y" : 1255
    },
    "isFadeOut" : true,
    "minX" : 1767,
    "maxX" : 1779,
    "minY" : 1232,
    "maxY" : 1279,
    "segments" : [ {
      "from" : {
        "x" : 1770,
        "y" : 1279
      },
      "to" : {
        "x" : 1773,
        "y" : 1255
      }
    }, {
      "from" : {
        "x" : 1773,
        "y" : 1255
      },
      "to" : {
        "x" : 1775,
        "y" : 1232
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1767,
        "y" : 1249
      },
      "b" : {
        "x" : 1779,
        "y" : 1261
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1773,
        "y" : 1255
      }
    },
    "inputs" : [ {
      "id" : 2938,
      "points" : [ {
        "x" : 1825,
        "y" : 1279
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 2936,
      "points" : [ {
        "x" : 1763,
        "y" : 1302
      } ]
    } ],
    "outputs" : [ {
      "id" : 2939,
      "points" : [ {
        "x" : 1829,
        "y" : 1229
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 2940,
      "points" : [ {
        "x" : 1772,
        "y" : 1215
      } ]
    } ],
    "catalysts" : [ {
      "id" : 2936,
      "points" : [ {
        "x" : 1734,
        "y" : 1302
      }, {
        "x" : 1716,
        "y" : 1279
      } ]
    } ]
  }, {
    "id" : 13434,
    "reactomeId" : 9660557,
    "displayName" : "RAS:GTP binds RAL GDS proteins",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 786,
      "y" : 314
    },
    "isFadeOut" : true,
    "minX" : 773,
    "maxX" : 807,
    "minY" : 309,
    "maxY" : 322,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 773,
        "y" : 322
      },
      "to" : {
        "x" : 786,
        "y" : 314
      }
    }, {
      "from" : {
        "x" : 786,
        "y" : 314
      },
      "to" : {
        "x" : 807,
        "y" : 309
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 801,
        "y" : 314
      },
      "b" : {
        "x" : 807,
        "y" : 309
      },
      "c" : {
        "x" : 799,
        "y" : 307
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 799,
        "y" : 307
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 786,
        "y" : 314
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 786,
        "y" : 314
      }
    },
    "inputs" : [ {
      "id" : 13437,
      "points" : [ {
        "x" : 717,
        "y" : 319
      } ]
    }, {
      "id" : 13435,
      "points" : [ {
        "x" : 794,
        "y" : 767
      } ]
    } ],
    "outputs" : [ {
      "id" : 13436
    } ]
  }, {
    "id" : 3450,
    "reactomeId" : 5675417,
    "displayName" : "PEBP1 binds activated RAF1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2383,
      "y" : 226
    },
    "isFadeOut" : true,
    "minX" : 2341,
    "maxX" : 2431,
    "minY" : 221,
    "maxY" : 255,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 2341,
        "y" : 255
      },
      "to" : {
        "x" : 2383,
        "y" : 226
      }
    }, {
      "from" : {
        "x" : 2383,
        "y" : 226
      },
      "to" : {
        "x" : 2431,
        "y" : 226
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2424,
        "y" : 230
      },
      "b" : {
        "x" : 2431,
        "y" : 226
      },
      "c" : {
        "x" : 2424,
        "y" : 222
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2424,
        "y" : 222
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2383,
        "y" : 226
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2383,
        "y" : 226
      }
    },
    "inputs" : [ {
      "id" : 3451,
      "points" : [ {
        "x" : 2271,
        "y" : 256
      } ]
    }, {
      "id" : 3452,
      "points" : [ {
        "x" : 2194,
        "y" : 473
      }, {
        "x" : 2333,
        "y" : 341
      } ]
    } ],
    "outputs" : [ {
      "id" : 3453
    } ]
  } ],
  "compartments" : [ {
    "id" : 304,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2532,
      "y" : 850
    },
    "minX" : 318,
    "maxX" : 4746,
    "minY" : 0,
    "maxY" : 1701,
    "prop" : {
      "x" : 318,
      "y" : 0,
      "width" : 4428,
      "height" : 1701
    },
    "textPosition" : {
      "x" : 711,
      "y" : 1219
    },
    "insets" : {
      "x" : 442,
      "y" : 469,
      "width" : 4132,
      "height" : 1175
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 305, 306, 307, 308, 309, 313, 314, 315, 316, 317, 318, 319, 320, 322, 323, 324, 325, 326, 327, 351, 353, 355, 356, 357, 359, 364, 386, 645, 648, 659, 660, 661, 662, 663, 665, 666, 669, 670, 671, 762, 813, 819, 820, 1079, 1081, 1085, 1061, 2202, 2203, 2204, 2205, 2206, 2211, 2212, 2209, 2227, 2228, 2229, 2230, 2231, 2234, 2236, 2238, 2235, 2254, 2255, 2256, 2253, 2264, 2265, 2266, 2263, 2268, 2273, 2274, 2275, 2276, 2277, 2279, 2284, 2285, 2842, 2851, 2854, 2871, 2886, 2884, 2905, 2906, 2938, 2939, 2967, 3005, 3004, 3009, 3008, 3038, 3039, 3040, 3041, 3042, 3043, 3073, 3077, 3072, 3079, 3081, 3082, 3083, 3078, 3103, 3104, 3102, 3344, 3346, 3358, 3359, 3364, 3450, 3451, 3452, 3453, 3461, 3462, 3463, 3465, 3474, 3472, 3478, 3473, 3476, 3483, 3565, 3566, 3567, 3568, 4161, 4162, 4163, 4164, 4165, 4166, 4167, 4169, 4171, 4172, 4173, 4170, 310, 3460, 4454, 4805, 4806, 4807, 4900, 4901, 4902, 4904, 4905, 4907, 5041, 5043, 5094, 5209, 5210, 5211, 5212, 5213, 5214, 5289, 5290, 5291, 5298, 5299, 5300, 6289, 6290, 6291, 6293, 6315, 6316, 6317, 13434, 13435, 13436, 13437, 13444, 13445, 13446, 13447, 13456, 13457, 13458, 13459, 13468, 13469, 13470, 13471, 13472, 13474 ]
  }, {
    "id" : 2854,
    "reactomeId" : 171907,
    "displayName" : "endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2757,
      "y" : 1057
    },
    "minX" : 2519,
    "maxX" : 2996,
    "minY" : 990,
    "maxY" : 1125,
    "prop" : {
      "x" : 2519,
      "y" : 990,
      "width" : 477,
      "height" : 135
    },
    "textPosition" : {
      "x" : 2569,
      "y" : 1048
    },
    "insets" : {
      "x" : 2566,
      "y" : 1035,
      "width" : 412,
      "height" : 79
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 2870, 2869, 2874, 2885, 2883 ]
  }, {
    "id" : 2905,
    "reactomeId" : 17963,
    "displayName" : "Golgi lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1653,
      "y" : 1341
    },
    "minX" : 1529,
    "maxX" : 1778,
    "minY" : 1171,
    "maxY" : 1512,
    "prop" : {
      "x" : 1529,
      "y" : 1171,
      "width" : 249,
      "height" : 341
    },
    "textPosition" : {
      "x" : 1597,
      "y" : 1397
    },
    "insets" : {
      "x" : 1563,
      "y" : 1212,
      "width" : 190,
      "height" : 273
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 2913, 2912, 2911, 2935, 2936, 2934, 2940, 2937 ]
  }, {
    "id" : 2906,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 4021,
      "y" : 1162
    },
    "minX" : 3702,
    "maxX" : 4341,
    "minY" : 1024,
    "maxY" : 1301,
    "prop" : {
      "x" : 3702,
      "y" : 1024,
      "width" : 639,
      "height" : 277
    },
    "textPosition" : {
      "x" : 3743,
      "y" : 1097
    },
    "insets" : {
      "x" : 3712,
      "y" : 1045,
      "width" : 612,
      "height" : 241
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 3003, 3007, 3351, 3349, 3355, 3356, 3365 ]
  } ],
  "notes" : [ {
    "id" : 3568,
    "displayName" : "plasma membrane",
    "renderableClass" : "Note",
    "position" : {
      "x" : 2856,
      "y" : 78
    },
    "minX" : 2784,
    "maxX" : 2928,
    "minY" : 58,
    "maxY" : 98,
    "prop" : {
      "x" : 2784,
      "y" : 58,
      "width" : 144,
      "height" : 40
    },
    "textPosition" : {
      "x" : 2794,
      "y" : 67
    }
  }, {
    "id" : 3565,
    "displayName" : "plasma membrane",
    "renderableClass" : "Note",
    "position" : {
      "x" : 780,
      "y" : 171
    },
    "minX" : 708,
    "maxX" : 852,
    "minY" : 151,
    "maxY" : 191,
    "prop" : {
      "x" : 708,
      "y" : 151,
      "width" : 144,
      "height" : 40
    },
    "textPosition" : {
      "x" : 718,
      "y" : 160
    }
  }, {
    "id" : 3566,
    "displayName" : "plasma membrane",
    "renderableClass" : "Note",
    "position" : {
      "x" : 1372,
      "y" : 319
    },
    "minX" : 1300,
    "maxX" : 1444,
    "minY" : 299,
    "maxY" : 339,
    "prop" : {
      "x" : 1300,
      "y" : 299,
      "width" : 144,
      "height" : 40
    },
    "textPosition" : {
      "x" : 1310,
      "y" : 308
    }
  }, {
    "id" : 3567,
    "displayName" : "plasma membrane",
    "renderableClass" : "Note",
    "position" : {
      "x" : 4514,
      "y" : 418
    },
    "minX" : 4442,
    "maxX" : 4586,
    "minY" : 398,
    "maxY" : 438,
    "prop" : {
      "x" : 4442,
      "y" : 398,
      "width" : 144,
      "height" : 40
    },
    "textPosition" : {
      "x" : 4452,
      "y" : 407
    }
  } ],
  "links" : [ {
    "id" : 3009,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 3729,
      "y" : 820
    },
    "isFadeOut" : true,
    "minX" : 3554,
    "maxX" : 3904,
    "minY" : 753,
    "maxY" : 887,
    "segments" : [ {
      "from" : {
        "x" : 3554,
        "y" : 753
      },
      "to" : {
        "x" : 3904,
        "y" : 887
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3723,
        "y" : 814
      },
      "b" : {
        "x" : 3735,
        "y" : 826
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3729,
        "y" : 820
      }
    },
    "inputs" : [ {
      "id" : 3008
    } ],
    "outputs" : [ {
      "id" : 3004
    } ]
  }, {
    "id" : 3525,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 247,
      "y" : 259
    },
    "isFadeOut" : true,
    "minX" : 150,
    "maxX" : 283,
    "minY" : 251,
    "maxY" : 567,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 150,
        "y" : 251
      },
      "to" : {
        "x" : 247,
        "y" : 259
      }
    }, {
      "from" : {
        "x" : 247,
        "y" : 259
      },
      "to" : {
        "x" : 283,
        "y" : 567
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 278,
        "y" : 561
      },
      "b" : {
        "x" : 283,
        "y" : 567
      },
      "c" : {
        "x" : 286,
        "y" : 560
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 286,
        "y" : 560
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 241,
        "y" : 253
      },
      "b" : {
        "x" : 253,
        "y" : 265
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 247,
        "y" : 259
      }
    },
    "inputs" : [ {
      "id" : 3501
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 4742,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 270,
      "y" : 221
    },
    "isFadeOut" : true,
    "minX" : 142,
    "maxX" : 285,
    "minY" : 190,
    "maxY" : 567,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 142,
        "y" : 190
      },
      "to" : {
        "x" : 270,
        "y" : 221
      }
    }, {
      "from" : {
        "x" : 270,
        "y" : 221
      },
      "to" : {
        "x" : 285,
        "y" : 567
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 281,
        "y" : 560
      },
      "b" : {
        "x" : 285,
        "y" : 567
      },
      "c" : {
        "x" : 289,
        "y" : 560
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 289,
        "y" : 560
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 264,
        "y" : 215
      },
      "b" : {
        "x" : 276,
        "y" : 227
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 270,
        "y" : 221
      }
    },
    "inputs" : [ {
      "id" : 4740
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3527,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 232,
      "y" : 296
    },
    "isFadeOut" : true,
    "minX" : 148,
    "maxX" : 282,
    "minY" : 290,
    "maxY" : 567,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 148,
        "y" : 303
      },
      "to" : {
        "x" : 232,
        "y" : 296
      }
    }, {
      "from" : {
        "x" : 232,
        "y" : 296
      },
      "to" : {
        "x" : 282,
        "y" : 567
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 277,
        "y" : 561
      },
      "b" : {
        "x" : 282,
        "y" : 567
      },
      "c" : {
        "x" : 285,
        "y" : 559
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 285,
        "y" : 559
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 226,
        "y" : 290
      },
      "b" : {
        "x" : 238,
        "y" : 302
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 232,
        "y" : 296
      }
    },
    "inputs" : [ {
      "id" : 3502
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3529,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 215,
      "y" : 369
    },
    "isFadeOut" : true,
    "minX" : 149,
    "maxX" : 279,
    "minY" : 363,
    "maxY" : 567,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 149,
        "y" : 373
      },
      "to" : {
        "x" : 215,
        "y" : 369
      }
    }, {
      "from" : {
        "x" : 215,
        "y" : 369
      },
      "to" : {
        "x" : 279,
        "y" : 567
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 273,
        "y" : 562
      },
      "b" : {
        "x" : 279,
        "y" : 567
      },
      "c" : {
        "x" : 281,
        "y" : 559
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 281,
        "y" : 559
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 209,
        "y" : 363
      },
      "b" : {
        "x" : 221,
        "y" : 375
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 215,
        "y" : 369
      }
    },
    "inputs" : [ {
      "id" : 3503
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3531,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 192,
      "y" : 446
    },
    "isFadeOut" : true,
    "minX" : 149,
    "maxX" : 273,
    "minY" : 440,
    "maxY" : 567,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 149,
        "y" : 448
      },
      "to" : {
        "x" : 192,
        "y" : 446
      }
    }, {
      "from" : {
        "x" : 192,
        "y" : 446
      },
      "to" : {
        "x" : 273,
        "y" : 567
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 266,
        "y" : 563
      },
      "b" : {
        "x" : 273,
        "y" : 567
      },
      "c" : {
        "x" : 272,
        "y" : 559
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 272,
        "y" : 559
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 186,
        "y" : 440
      },
      "b" : {
        "x" : 198,
        "y" : 452
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 192,
        "y" : 446
      }
    },
    "inputs" : [ {
      "id" : 3504
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3533,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 183,
      "y" : 526
    },
    "isFadeOut" : true,
    "minX" : 149,
    "maxX" : 255,
    "minY" : 520,
    "maxY" : 567,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 149,
        "y" : 525
      },
      "to" : {
        "x" : 183,
        "y" : 526
      }
    }, {
      "from" : {
        "x" : 183,
        "y" : 526
      },
      "to" : {
        "x" : 255,
        "y" : 567
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 247,
        "y" : 567
      },
      "b" : {
        "x" : 255,
        "y" : 567
      },
      "c" : {
        "x" : 251,
        "y" : 560
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 251,
        "y" : 560
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 177,
        "y" : 520
      },
      "b" : {
        "x" : 189,
        "y" : 532
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 183,
        "y" : 526
      }
    },
    "inputs" : [ {
      "id" : 3505
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3535,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 194,
      "y" : 594
    },
    "isFadeOut" : true,
    "minX" : 149,
    "maxX" : 240,
    "minY" : 588,
    "maxY" : 600,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 149,
        "y" : 595
      },
      "to" : {
        "x" : 240,
        "y" : 593
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 233,
        "y" : 597
      },
      "b" : {
        "x" : 240,
        "y" : 593
      },
      "c" : {
        "x" : 233,
        "y" : 589
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 233,
        "y" : 589
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 188,
        "y" : 588
      },
      "b" : {
        "x" : 200,
        "y" : 600
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 194,
        "y" : 594
      }
    },
    "inputs" : [ {
      "id" : 3506
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3537,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 180,
      "y" : 638
    },
    "isFadeOut" : true,
    "minX" : 147,
    "maxX" : 240,
    "minY" : 610,
    "maxY" : 648,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 147,
        "y" : 648
      },
      "to" : {
        "x" : 180,
        "y" : 638
      }
    }, {
      "from" : {
        "x" : 180,
        "y" : 638
      },
      "to" : {
        "x" : 240,
        "y" : 610
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 235,
        "y" : 617
      },
      "b" : {
        "x" : 240,
        "y" : 610
      },
      "c" : {
        "x" : 232,
        "y" : 609
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 232,
        "y" : 609
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 174,
        "y" : 632
      },
      "b" : {
        "x" : 186,
        "y" : 644
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 180,
        "y" : 638
      }
    },
    "inputs" : [ {
      "id" : 3507
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3539,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 186,
      "y" : 702
    },
    "isFadeOut" : true,
    "minX" : 151,
    "maxX" : 267,
    "minY" : 619,
    "maxY" : 719,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 151,
        "y" : 719
      },
      "to" : {
        "x" : 186,
        "y" : 702
      }
    }, {
      "from" : {
        "x" : 186,
        "y" : 702
      },
      "to" : {
        "x" : 267,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 265,
        "y" : 627
      },
      "b" : {
        "x" : 267,
        "y" : 619
      },
      "c" : {
        "x" : 259,
        "y" : 621
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 259,
        "y" : 621
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 180,
        "y" : 696
      },
      "b" : {
        "x" : 192,
        "y" : 708
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 186,
        "y" : 702
      }
    },
    "inputs" : [ {
      "id" : 3513
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3541,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 166,
      "y" : 809
    },
    "isFadeOut" : true,
    "minX" : 151,
    "maxX" : 274,
    "minY" : 619,
    "maxY" : 815,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 151,
        "y" : 813
      },
      "to" : {
        "x" : 166,
        "y" : 809
      }
    }, {
      "from" : {
        "x" : 166,
        "y" : 809
      },
      "to" : {
        "x" : 274,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 274,
        "y" : 627
      },
      "b" : {
        "x" : 274,
        "y" : 619
      },
      "c" : {
        "x" : 267,
        "y" : 623
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 267,
        "y" : 623
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 160,
        "y" : 803
      },
      "b" : {
        "x" : 172,
        "y" : 815
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 166,
        "y" : 809
      }
    },
    "inputs" : [ {
      "id" : 3509
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3543,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 164,
      "y" : 874
    },
    "isFadeOut" : true,
    "minX" : 148,
    "maxX" : 277,
    "minY" : 619,
    "maxY" : 880,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 148,
        "y" : 878
      },
      "to" : {
        "x" : 164,
        "y" : 874
      }
    }, {
      "from" : {
        "x" : 164,
        "y" : 874
      },
      "to" : {
        "x" : 277,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 278,
        "y" : 627
      },
      "b" : {
        "x" : 277,
        "y" : 619
      },
      "c" : {
        "x" : 271,
        "y" : 624
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 271,
        "y" : 624
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 158,
        "y" : 868
      },
      "b" : {
        "x" : 170,
        "y" : 880
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 164,
        "y" : 874
      }
    },
    "inputs" : [ {
      "id" : 3510
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3545,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 168,
      "y" : 934
    },
    "isFadeOut" : true,
    "minX" : 148,
    "maxX" : 279,
    "minY" : 619,
    "maxY" : 940,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 148,
        "y" : 940
      },
      "to" : {
        "x" : 168,
        "y" : 934
      }
    }, {
      "from" : {
        "x" : 168,
        "y" : 934
      },
      "to" : {
        "x" : 279,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 280,
        "y" : 627
      },
      "b" : {
        "x" : 279,
        "y" : 619
      },
      "c" : {
        "x" : 273,
        "y" : 624
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 273,
        "y" : 624
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 162,
        "y" : 928
      },
      "b" : {
        "x" : 174,
        "y" : 940
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 168,
        "y" : 934
      }
    },
    "inputs" : [ {
      "id" : 3508
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3547,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 172,
      "y" : 1004
    },
    "isFadeOut" : true,
    "minX" : 148,
    "maxX" : 280,
    "minY" : 619,
    "maxY" : 1011,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 148,
        "y" : 1011
      },
      "to" : {
        "x" : 172,
        "y" : 1004
      }
    }, {
      "from" : {
        "x" : 172,
        "y" : 1004
      },
      "to" : {
        "x" : 280,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 282,
        "y" : 627
      },
      "b" : {
        "x" : 280,
        "y" : 619
      },
      "c" : {
        "x" : 274,
        "y" : 625
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 274,
        "y" : 625
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 166,
        "y" : 998
      },
      "b" : {
        "x" : 178,
        "y" : 1010
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 172,
        "y" : 1004
      }
    },
    "inputs" : [ {
      "id" : 3512
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3549,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 184,
      "y" : 1080
    },
    "isFadeOut" : true,
    "minX" : 147,
    "maxX" : 281,
    "minY" : 619,
    "maxY" : 1086,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 147,
        "y" : 1086
      },
      "to" : {
        "x" : 184,
        "y" : 1080
      }
    }, {
      "from" : {
        "x" : 184,
        "y" : 1080
      },
      "to" : {
        "x" : 281,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 283,
        "y" : 627
      },
      "b" : {
        "x" : 281,
        "y" : 619
      },
      "c" : {
        "x" : 276,
        "y" : 625
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 276,
        "y" : 625
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 178,
        "y" : 1074
      },
      "b" : {
        "x" : 190,
        "y" : 1086
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 184,
        "y" : 1080
      }
    },
    "inputs" : [ {
      "id" : 3497
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3551,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 197,
      "y" : 1146
    },
    "isFadeOut" : true,
    "minX" : 148,
    "maxX" : 282,
    "minY" : 619,
    "maxY" : 1155,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 148,
        "y" : 1155
      },
      "to" : {
        "x" : 197,
        "y" : 1146
      }
    }, {
      "from" : {
        "x" : 197,
        "y" : 1146
      },
      "to" : {
        "x" : 282,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 285,
        "y" : 626
      },
      "b" : {
        "x" : 282,
        "y" : 619
      },
      "c" : {
        "x" : 277,
        "y" : 625
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 277,
        "y" : 625
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 191,
        "y" : 1140
      },
      "b" : {
        "x" : 203,
        "y" : 1152
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 197,
        "y" : 1146
      }
    },
    "inputs" : [ {
      "id" : 3496
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3040,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 3359,
      "y" : 977
    },
    "isFadeOut" : true,
    "minX" : 3220,
    "maxX" : 3499,
    "minY" : 968,
    "maxY" : 987,
    "segments" : [ {
      "from" : {
        "x" : 3499,
        "y" : 987
      },
      "to" : {
        "x" : 3220,
        "y" : 968
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3353,
        "y" : 971
      },
      "b" : {
        "x" : 3365,
        "y" : 983
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3359,
        "y" : 977
      }
    },
    "inputs" : [ {
      "id" : 3039
    } ],
    "outputs" : [ {
      "id" : 2266
    } ]
  }, {
    "id" : 3554,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 217,
      "y" : 1212
    },
    "isFadeOut" : true,
    "minX" : 148,
    "maxX" : 283,
    "minY" : 619,
    "maxY" : 1225,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 148,
        "y" : 1225
      },
      "to" : {
        "x" : 217,
        "y" : 1212
      }
    }, {
      "from" : {
        "x" : 217,
        "y" : 1212
      },
      "to" : {
        "x" : 283,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 286,
        "y" : 626
      },
      "b" : {
        "x" : 283,
        "y" : 619
      },
      "c" : {
        "x" : 278,
        "y" : 625
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 278,
        "y" : 625
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 211,
        "y" : 1206
      },
      "b" : {
        "x" : 223,
        "y" : 1218
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 217,
        "y" : 1212
      }
    },
    "inputs" : [ {
      "id" : 3495
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 13474,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 402,
      "y" : 780
    },
    "isFadeOut" : true,
    "minX" : 396,
    "maxX" : 408,
    "minY" : 756,
    "maxY" : 805,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 401,
        "y" : 805
      },
      "to" : {
        "x" : 403,
        "y" : 756
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 407,
        "y" : 763
      },
      "b" : {
        "x" : 403,
        "y" : 756
      },
      "c" : {
        "x" : 399,
        "y" : 763
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 399,
        "y" : 763
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 396,
        "y" : 774
      },
      "b" : {
        "x" : 408,
        "y" : 786
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 402,
        "y" : 780
      }
    },
    "inputs" : [ {
      "id" : 13472
    } ],
    "outputs" : [ {
      "id" : 307
    } ]
  }, {
    "id" : 2851,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 1805,
      "y" : 647
    },
    "isFadeOut" : true,
    "minX" : 1546,
    "maxX" : 2064,
    "minY" : 534,
    "maxY" : 761,
    "segments" : [ {
      "from" : {
        "x" : 2064,
        "y" : 761
      },
      "to" : {
        "x" : 1546,
        "y" : 534
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1799,
        "y" : 641
      },
      "b" : {
        "x" : 1811,
        "y" : 653
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1805,
        "y" : 647
      }
    },
    "inputs" : [ {
      "id" : 2205
    } ],
    "outputs" : [ {
      "id" : 2235
    } ]
  }, {
    "id" : 3556,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 234,
      "y" : 1291
    },
    "isFadeOut" : true,
    "minX" : 147,
    "maxX" : 284,
    "minY" : 619,
    "maxY" : 1306,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 147,
        "y" : 1306
      },
      "to" : {
        "x" : 234,
        "y" : 1291
      }
    }, {
      "from" : {
        "x" : 234,
        "y" : 1291
      },
      "to" : {
        "x" : 284,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 287,
        "y" : 626
      },
      "b" : {
        "x" : 284,
        "y" : 619
      },
      "c" : {
        "x" : 279,
        "y" : 626
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 279,
        "y" : 626
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 228,
        "y" : 1285
      },
      "b" : {
        "x" : 240,
        "y" : 1297
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 234,
        "y" : 1291
      }
    },
    "inputs" : [ {
      "id" : 3492
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3558,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 248,
      "y" : 1366
    },
    "isFadeOut" : true,
    "minX" : 148,
    "maxX" : 285,
    "minY" : 619,
    "maxY" : 1391,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 148,
        "y" : 1391
      },
      "to" : {
        "x" : 248,
        "y" : 1366
      }
    }, {
      "from" : {
        "x" : 248,
        "y" : 1366
      },
      "to" : {
        "x" : 285,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 289,
        "y" : 626
      },
      "b" : {
        "x" : 285,
        "y" : 619
      },
      "c" : {
        "x" : 281,
        "y" : 626
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 281,
        "y" : 626
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 242,
        "y" : 1360
      },
      "b" : {
        "x" : 254,
        "y" : 1372
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 248,
        "y" : 1366
      }
    },
    "inputs" : [ {
      "id" : 3498
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 4454,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 592,
      "y" : 822
    },
    "isFadeOut" : true,
    "minX" : 575,
    "maxX" : 610,
    "minY" : 705,
    "maxY" : 939,
    "segments" : [ {
      "from" : {
        "x" : 610,
        "y" : 939
      },
      "to" : {
        "x" : 575,
        "y" : 705
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 586,
        "y" : 816
      },
      "b" : {
        "x" : 598,
        "y" : 828
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 592,
        "y" : 822
      }
    },
    "inputs" : [ {
      "id" : 317
    } ],
    "outputs" : [ {
      "id" : 314
    } ]
  }, {
    "id" : 3560,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 268,
      "y" : 1461
    },
    "isFadeOut" : true,
    "minX" : 149,
    "maxX" : 285,
    "minY" : 619,
    "maxY" : 1490,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 149,
        "y" : 1490
      },
      "to" : {
        "x" : 268,
        "y" : 1461
      }
    }, {
      "from" : {
        "x" : 268,
        "y" : 1461
      },
      "to" : {
        "x" : 285,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 289,
        "y" : 626
      },
      "b" : {
        "x" : 285,
        "y" : 619
      },
      "c" : {
        "x" : 281,
        "y" : 626
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 281,
        "y" : 626
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 262,
        "y" : 1455
      },
      "b" : {
        "x" : 274,
        "y" : 1467
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 268,
        "y" : 1461
      }
    },
    "inputs" : [ {
      "id" : 3500
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3562,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 285,
      "y" : 1554
    },
    "isFadeOut" : true,
    "minX" : 151,
    "maxX" : 291,
    "minY" : 619,
    "maxY" : 1585,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 151,
        "y" : 1585
      },
      "to" : {
        "x" : 285,
        "y" : 1554
      }
    }, {
      "from" : {
        "x" : 285,
        "y" : 1554
      },
      "to" : {
        "x" : 285,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 289,
        "y" : 626
      },
      "b" : {
        "x" : 285,
        "y" : 619
      },
      "c" : {
        "x" : 281,
        "y" : 626
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 281,
        "y" : 626
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 279,
        "y" : 1548
      },
      "b" : {
        "x" : 291,
        "y" : 1560
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 285,
        "y" : 1554
      }
    },
    "inputs" : [ {
      "id" : 3499
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 3564,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 501,
      "y" : 1861
    },
    "isFadeOut" : true,
    "minX" : 150,
    "maxX" : 507,
    "minY" : 619,
    "maxY" : 1867,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 150,
        "y" : 1730
      },
      "to" : {
        "x" : 501,
        "y" : 1861
      }
    }, {
      "from" : {
        "x" : 501,
        "y" : 1861
      },
      "to" : {
        "x" : 289,
        "y" : 619
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 294,
        "y" : 625
      },
      "b" : {
        "x" : 289,
        "y" : 619
      },
      "c" : {
        "x" : 286,
        "y" : 627
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 286,
        "y" : 627
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 495,
        "y" : 1855
      },
      "b" : {
        "x" : 507,
        "y" : 1867
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 501,
        "y" : 1861
      }
    },
    "inputs" : [ {
      "id" : 3511
    } ],
    "outputs" : [ {
      "id" : 310
    } ]
  }, {
    "id" : 2231,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1918,
      "y" : 838
    },
    "isFadeOut" : true,
    "minX" : 1781,
    "maxX" : 2056,
    "minY" : 795,
    "maxY" : 881,
    "segments" : [ {
      "from" : {
        "x" : 1781,
        "y" : 881
      },
      "to" : {
        "x" : 2056,
        "y" : 795
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1912,
        "y" : 832
      },
      "b" : {
        "x" : 1924,
        "y" : 844
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1918,
        "y" : 838
      }
    },
    "inputs" : [ {
      "id" : 2230
    } ],
    "outputs" : [ {
      "id" : 2205
    } ]
  }, {
    "id" : 2236,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1665,
      "y" : 643
    },
    "isFadeOut" : true,
    "minX" : 1528,
    "maxX" : 1727,
    "minY" : 534,
    "maxY" : 872,
    "segments" : [ {
      "from" : {
        "x" : 1727,
        "y" : 872
      },
      "to" : {
        "x" : 1665,
        "y" : 643
      }
    }, {
      "from" : {
        "x" : 1665,
        "y" : 643
      },
      "to" : {
        "x" : 1528,
        "y" : 534
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1659,
        "y" : 637
      },
      "b" : {
        "x" : 1671,
        "y" : 649
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1665,
        "y" : 643
      }
    },
    "inputs" : [ {
      "id" : 2230
    } ],
    "outputs" : [ {
      "id" : 2235
    } ]
  }, {
    "id" : 3005,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 3613,
      "y" : 718
    },
    "isFadeOut" : true,
    "minX" : 3525,
    "maxX" : 3914,
    "minY" : 649,
    "maxY" : 876,
    "segments" : [ {
      "from" : {
        "x" : 3525,
        "y" : 649
      },
      "to" : {
        "x" : 3613,
        "y" : 718
      }
    }, {
      "from" : {
        "x" : 3613,
        "y" : 718
      },
      "to" : {
        "x" : 3914,
        "y" : 876
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3607,
        "y" : 712
      },
      "b" : {
        "x" : 3619,
        "y" : 724
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3613,
        "y" : 718
      }
    },
    "inputs" : [ {
      "id" : 2265
    } ],
    "outputs" : [ {
      "id" : 3004
    } ]
  }, {
    "id" : 2238,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 1525,
      "y" : 570
    },
    "isFadeOut" : true,
    "minX" : 1512,
    "maxX" : 1538,
    "minY" : 534,
    "maxY" : 606,
    "segments" : [ {
      "from" : {
        "x" : 1512,
        "y" : 534
      },
      "to" : {
        "x" : 1538,
        "y" : 606
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1519,
        "y" : 564
      },
      "b" : {
        "x" : 1531,
        "y" : 576
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1525,
        "y" : 570
      }
    },
    "inputs" : [ {
      "id" : 2235
    } ],
    "outputs" : [ {
      "id" : 2228
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 4746,
  "minY" : 0,
  "maxY" : 1867,
  "disease" : true
}