{
  "dbId" : 5658034,
  "stableId" : "R-HSA-5658034",
  "displayName" : "HHAT G278V doesn't palmitoylate Hh-Np",
  "forNormalDraw" : false,
  "nodes" : [ {
    "id" : 579,
    "reactomeId" : 5362382,
    "displayName" : "NglycoAsn-Hh precursors",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 308,
      "y" : 764
    },
    "isFadeOut" : true,
    "minX" : 261,
    "maxX" : 380,
    "minY" : 746,
    "maxY" : 782,
    "prop" : {
      "x" : 261,
      "y" : 746,
      "width" : 95,
      "height" : 36
    },
    "textPosition" : {
      "x" : 260,
      "y" : 746
    },
    "connectors" : [ {
      "edgeId" : 3,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 362,
          "y" : 762
        },
        "to" : {
          "x" : 380,
          "y" : 761
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 581,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4,
    "reactomeId" : 5358318,
    "displayName" : "Hh precursors",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 153,
      "y" : 766
    },
    "isFadeOut" : true,
    "minX" : 97,
    "maxX" : 209,
    "minY" : 741,
    "maxY" : 791,
    "prop" : {
      "x" : 97,
      "y" : 741,
      "width" : 112,
      "height" : 50
    },
    "textPosition" : {
      "x" : 104,
      "y" : 755
    },
    "connectors" : [ {
      "edgeId" : 581,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 5,
    "reactomeId" : 174692,
    "displayName" : "P4HB",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 313,
      "y" : 677
    },
    "isFadeOut" : true,
    "minX" : 250,
    "maxX" : 661,
    "minY" : 617,
    "maxY" : 761,
    "prop" : {
      "x" : 250,
      "y" : 659,
      "width" : 126,
      "height" : 36
    },
    "textPosition" : {
      "x" : 292,
      "y" : 666
    },
    "connectors" : [ {
      "edgeId" : 3,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 327,
          "y" : 698
        },
        "to" : {
          "x" : 380,
          "y" : 761
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 7,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 337,
          "y" : 656
        },
        "to" : {
          "x" : 393,
          "y" : 618
        }
      }, {
        "from" : {
          "x" : 393,
          "y" : 618
        },
        "to" : {
          "x" : 614,
          "y" : 617
        }
      }, {
        "from" : {
          "x" : 614,
          "y" : 617
        },
        "to" : {
          "x" : 661,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 340,
          "y" : 649
        },
        "b" : {
          "x" : 337,
          "y" : 656
        },
        "c" : {
          "x" : 345,
          "y" : 655
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 345,
          "y" : 655
        }
      }
    } ]
  }, {
    "id" : 8,
    "reactomeId" : 174672,
    "displayName" : "CHOL",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 574,
      "y" : 650
    },
    "isFadeOut" : true,
    "minX" : 532,
    "maxX" : 616,
    "minY" : 635,
    "maxY" : 732,
    "prop" : {
      "x" : 532,
      "y" : 635,
      "width" : 84,
      "height" : 30
    },
    "textPosition" : {
      "x" : 554,
      "y" : 639
    },
    "connectors" : [ {
      "edgeId" : 7,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 580,
          "y" : 668
        },
        "to" : {
          "x" : 608,
          "y" : 732
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 649,
    "reactomeId" : 445456,
    "displayName" : "DISP2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 973,
      "y" : 146
    },
    "isFadeOut" : true,
    "minX" : 806,
    "maxX" : 1013,
    "minY" : 58,
    "maxY" : 174,
    "prop" : {
      "x" : 933,
      "y" : 133,
      "width" : 80,
      "height" : 26
    },
    "textPosition" : {
      "x" : 951,
      "y" : 135
    },
    "connectors" : [ {
      "edgeId" : 656,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 964,
          "y" : 162
        },
        "to" : {
          "x" : 954,
          "y" : 174
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 657,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 948,
          "y" : 130
        },
        "to" : {
          "x" : 806,
          "y" : 58
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 940,
          "y" : 130
        },
        "b" : {
          "x" : 948,
          "y" : 130
        },
        "c" : {
          "x" : 944,
          "y" : 123
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 944,
          "y" : 123
        }
      }
    } ]
  }, {
    "id" : 9,
    "reactomeId" : 5358332,
    "displayName" : "N-terminal CHOL-Hh fragments",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 768,
      "y" : 563
    },
    "minX" : 661,
    "maxX" : 872,
    "minY" : 545,
    "maxY" : 753,
    "prop" : {
      "x" : 708,
      "y" : 545,
      "width" : 121,
      "height" : 36
    },
    "textPosition" : {
      "x" : 712,
      "y" : 545
    },
    "connectors" : [ {
      "edgeId" : 7,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 757,
          "y" : 587
        },
        "to" : {
          "x" : 661,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 757,
          "y" : 595
        },
        "b" : {
          "x" : 757,
          "y" : 587
        },
        "c" : {
          "x" : 750,
          "y" : 591
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 750,
          "y" : 591
        }
      }
    }, {
      "edgeId" : 11,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 835,
          "y" : 561
        },
        "to" : {
          "x" : 872,
          "y" : 561
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 154108,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 835,
          "y" : 561
        },
        "to" : {
          "x" : 872,
          "y" : 561
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 10,
    "reactomeId" : 5358286,
    "displayName" : "C-terminal Hh fragments",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 765,
      "y" : 753
    },
    "isFadeOut" : true,
    "minX" : 661,
    "maxX" : 855,
    "minY" : 731,
    "maxY" : 771,
    "prop" : {
      "x" : 715,
      "y" : 735,
      "width" : 100,
      "height" : 36
    },
    "textPosition" : {
      "x" : 717,
      "y" : 735
    },
    "connectors" : [ {
      "edgeId" : 7,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 709,
          "y" : 753
        },
        "to" : {
          "x" : 661,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 702,
          "y" : 757
        },
        "b" : {
          "x" : 709,
          "y" : 753
        },
        "c" : {
          "x" : 702,
          "y" : 749
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 702,
          "y" : 749
        }
      }
    }, {
      "edgeId" : 587,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 821,
          "y" : 740
        },
        "to" : {
          "x" : 855,
          "y" : 731
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 650,
    "reactomeId" : 5362421,
    "displayName" : "Hh-Np:DISP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 805,
      "y" : 174
    },
    "isFadeOut" : true,
    "minX" : 768,
    "maxX" : 842,
    "minY" : 95,
    "maxY" : 195,
    "prop" : {
      "x" : 768,
      "y" : 153,
      "width" : 74,
      "height" : 42
    },
    "textPosition" : {
      "x" : 780,
      "y" : 160
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 656,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 657,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 805,
          "y" : 150
        },
        "to" : {
          "x" : 805,
          "y" : 95
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12,
    "reactomeId" : 5358339,
    "displayName" : "Palmitoyl-CoA",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 827,
      "y" : 499
    },
    "isFadeOut" : true,
    "minX" : 773,
    "maxX" : 881,
    "minY" : 484,
    "maxY" : 561,
    "prop" : {
      "x" : 773,
      "y" : 484,
      "width" : 108,
      "height" : 30
    },
    "textPosition" : {
      "x" : 781,
      "y" : 488
    },
    "isCrossed" : true,
    "connectors" : [ {
      "edgeId" : 11,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 837,
          "y" : 517
        },
        "to" : {
          "x" : 872,
          "y" : 561
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 154108,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 837,
          "y" : 517
        },
        "to" : {
          "x" : 872,
          "y" : 561
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 588,
    "reactomeId" : 5362377,
    "displayName" : "OS9/ERLEC1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 817,
      "y" : 680
    },
    "isFadeOut" : true,
    "minX" : 765,
    "maxX" : 1752,
    "minY" : 593,
    "maxY" : 857,
    "prop" : {
      "x" : 765,
      "y" : 667,
      "width" : 105,
      "height" : 27
    },
    "textPosition" : {
      "x" : 776,
      "y" : 670
    },
    "connectors" : [ {
      "edgeId" : 587,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 827,
          "y" : 700
        },
        "to" : {
          "x" : 855,
          "y" : 731
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 623,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 876,
          "y" : 674
        },
        "to" : {
          "x" : 1722,
          "y" : 593
        }
      }, {
        "from" : {
          "x" : 1722,
          "y" : 593
        },
        "to" : {
          "x" : 1752,
          "y" : 857
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 883,
          "y" : 669
        },
        "b" : {
          "x" : 876,
          "y" : 674
        },
        "c" : {
          "x" : 883,
          "y" : 677
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 883,
          "y" : 677
        }
      }
    } ]
  }, {
    "id" : 13,
    "reactomeId" : 162743,
    "displayName" : "CoA-SH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 974,
      "y" : 500
    },
    "isFadeOut" : true,
    "minX" : 942,
    "maxX" : 1006,
    "minY" : 485,
    "maxY" : 563,
    "prop" : {
      "x" : 942,
      "y" : 485,
      "width" : 64,
      "height" : 30
    },
    "textPosition" : {
      "x" : 947,
      "y" : 489
    },
    "isCrossed" : true,
    "connectors" : [ {
      "edgeId" : 11,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 966,
          "y" : 518
        },
        "to" : {
          "x" : 943,
          "y" : 563
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 966,
          "y" : 526
        },
        "b" : {
          "x" : 966,
          "y" : 518
        },
        "c" : {
          "x" : 959,
          "y" : 522
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 959,
          "y" : 522
        }
      }
    }, {
      "edgeId" : 154108,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 966,
          "y" : 518
        },
        "to" : {
          "x" : 943,
          "y" : 563
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 966,
          "y" : 526
        },
        "b" : {
          "x" : 966,
          "y" : 518
        },
        "c" : {
          "x" : 959,
          "y" : 522
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 959,
          "y" : 522
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 589,
    "reactomeId" : 5362409,
    "displayName" : "C-terminal Hh fragments:OS9/ERLEC1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 982,
      "y" : 731
    },
    "isFadeOut" : true,
    "minX" : 913,
    "maxX" : 1182,
    "minY" : 707,
    "maxY" : 799,
    "prop" : {
      "x" : 913,
      "y" : 707,
      "width" : 139,
      "height" : 48
    },
    "textPosition" : {
      "x" : 934,
      "y" : 706
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 587,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 599,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1055,
          "y" : 754
        },
        "to" : {
          "x" : 1182,
          "y" : 799
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 14,
    "reactomeId" : 5358329,
    "displayName" : "Hh-Np",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1080,
      "y" : 560
    },
    "isFadeOut" : true,
    "minX" : 943,
    "maxX" : 1110,
    "minY" : 546,
    "maxY" : 575,
    "prop" : {
      "x" : 1050,
      "y" : 546,
      "width" : 60,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1057,
      "y" : 550
    },
    "isCrossed" : true,
    "connectors" : [ {
      "edgeId" : 648,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 11,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1044,
          "y" : 560
        },
        "to" : {
          "x" : 943,
          "y" : 563
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1037,
          "y" : 564
        },
        "b" : {
          "x" : 1044,
          "y" : 560
        },
        "c" : {
          "x" : 1037,
          "y" : 556
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1037,
          "y" : 556
        }
      }
    }, {
      "edgeId" : 154108,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1044,
          "y" : 560
        },
        "to" : {
          "x" : 943,
          "y" : 563
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1037,
          "y" : 564
        },
        "b" : {
          "x" : 1044,
          "y" : 560
        },
        "c" : {
          "x" : 1037,
          "y" : 556
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1037,
          "y" : 556
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 655,
    "reactomeId" : 5362423,
    "displayName" : "Hh-Np",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1079,
      "y" : 175
    },
    "isFadeOut" : true,
    "minX" : 954,
    "maxX" : 1366,
    "minY" : 164,
    "maxY" : 186,
    "prop" : {
      "x" : 1055,
      "y" : 164,
      "width" : 49,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1056,
      "y" : 164
    },
    "connectors" : [ {
      "edgeId" : 648,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 656,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1049,
          "y" : 174
        },
        "to" : {
          "x" : 954,
          "y" : 174
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 786,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1110,
          "y" : 175
        },
        "to" : {
          "x" : 1366,
          "y" : 175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 827,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 15,
    "reactomeId" : 5358317,
    "displayName" : "HHAT",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 917,
      "y" : 413
    },
    "isFadeOut" : true,
    "minX" : 884,
    "maxX" : 950,
    "minY" : 400,
    "maxY" : 554,
    "prop" : {
      "x" : 884,
      "y" : 400,
      "width" : 66,
      "height" : 26
    },
    "textPosition" : {
      "x" : 896,
      "y" : 402
    },
    "connectors" : [ {
      "edgeId" : 11,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 916,
          "y" : 429
        },
        "to" : {
          "x" : 912,
          "y" : 546
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 912,
          "y" : 550
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 912,
          "y" : 550
        }
      }
    } ]
  }, {
    "id" : 658,
    "reactomeId" : 5362373,
    "displayName" : "SCUBE2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 736,
      "y" : 119
    },
    "isFadeOut" : true,
    "minX" : 707,
    "maxX" : 805,
    "minY" : 95,
    "maxY" : 130,
    "prop" : {
      "x" : 707,
      "y" : 108,
      "width" : 58,
      "height" : 22
    },
    "textPosition" : {
      "x" : 707,
      "y" : 108
    },
    "connectors" : [ {
      "edgeId" : 657,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 768,
          "y" : 108
        },
        "to" : {
          "x" : 805,
          "y" : 95
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 787,
    "reactomeId" : 5362430,
    "displayName" : "GPI-GPC5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1341,
      "y" : 141
    },
    "isFadeOut" : true,
    "minX" : 1266,
    "maxX" : 1417,
    "minY" : 117,
    "maxY" : 175,
    "prop" : {
      "x" : 1266,
      "y" : 123,
      "width" : 151,
      "height" : 36
    },
    "innerProp" : {
      "x" : 1266,
      "y" : 129,
      "width" : 151,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1309,
      "y" : 130
    },
    "nodeAttachments" : [ {
      "reactomeId" : 2076282,
      "label" : "G",
      "description" : "O-xylosyl-L-serine (ChEBI:63666) at unknown position",
      "shape" : {
        "a" : {
          "x" : 1276,
          "y" : 117
        },
        "b" : {
          "x" : 1288,
          "y" : 129
        },
        "s" : "G",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1282,
          "y" : 123
        }
      }
    }, {
      "reactomeId" : 5362357,
      "label" : "G",
      "description" : "O-xylosyl-L-serine (beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group) at unknown position",
      "shape" : {
        "a" : {
          "x" : 1292,
          "y" : 117
        },
        "b" : {
          "x" : 1304,
          "y" : 129
        },
        "s" : "G",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1298,
          "y" : 123
        }
      }
    }, {
      "reactomeId" : 5362399,
      "label" : "PI",
      "description" : "glycosylphosphatidylinositolated residue at unknown position",
      "shape" : {
        "a" : {
          "x" : 1308,
          "y" : 117
        },
        "b" : {
          "x" : 1320,
          "y" : 129
        },
        "s" : "PI",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1314,
          "y" : 123
        }
      }
    } ],
    "connectors" : [ {
      "edgeId" : 786,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1354,
          "y" : 162
        },
        "to" : {
          "x" : 1366,
          "y" : 175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 659,
    "reactomeId" : 5362543,
    "displayName" : "Hh-Np:SCUBE2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 807,
      "y" : 16
    },
    "isFadeOut" : true,
    "minX" : 754,
    "maxX" : 860,
    "minY" : 0,
    "maxY" : 58,
    "prop" : {
      "x" : 754,
      "y" : 0,
      "width" : 106,
      "height" : 32
    },
    "textPosition" : {
      "x" : 757,
      "y" : 11
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 657,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 806,
          "y" : 35
        },
        "to" : {
          "x" : 806,
          "y" : 58
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 810,
          "y" : 42
        },
        "b" : {
          "x" : 806,
          "y" : 35
        },
        "c" : {
          "x" : 802,
          "y" : 42
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 802,
          "y" : 42
        }
      }
    } ]
  }, {
    "id" : 788,
    "reactomeId" : 5362428,
    "displayName" : "Hh-Np:GPI-GPC5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1498,
      "y" : 173
    },
    "isFadeOut" : true,
    "minX" : 1461,
    "maxX" : 1536,
    "minY" : 150,
    "maxY" : 197,
    "prop" : {
      "x" : 1461,
      "y" : 150,
      "width" : 75,
      "height" : 47
    },
    "textPosition" : {
      "x" : 1461,
      "y" : 162
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 786,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 799,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 602,
    "reactomeId" : 5362413,
    "displayName" : "C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1314,
      "y" : 841
    },
    "isFadeOut" : true,
    "minX" : 1241,
    "maxX" : 1416,
    "minY" : 790,
    "maxY" : 880,
    "prop" : {
      "x" : 1241,
      "y" : 802,
      "width" : 146,
      "height" : 78
    },
    "textPosition" : {
      "x" : 1249,
      "y" : 803
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 617,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1390,
          "y" : 844
        },
        "to" : {
          "x" : 1402,
          "y" : 845
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 617,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1369,
          "y" : 799
        },
        "to" : {
          "x" : 1386,
          "y" : 790
        }
      }, {
        "from" : {
          "x" : 1386,
          "y" : 790
        },
        "to" : {
          "x" : 1410,
          "y" : 828
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1412,
          "y" : 831
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1412,
          "y" : 831
        }
      }
    }, {
      "edgeId" : 599,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 603,
    "reactomeId" : 5362378,
    "displayName" : "SEL1:SYVN1 dimer:DERL2:VCP hexamer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1096,
      "y" : 847
    },
    "isFadeOut" : true,
    "minX" : 1035,
    "maxX" : 1752,
    "minY" : 629,
    "maxY" : 875,
    "prop" : {
      "x" : 1035,
      "y" : 820,
      "width" : 123,
      "height" : 55
    },
    "textPosition" : {
      "x" : 1037,
      "y" : 826
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 623,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1102,
          "y" : 817
        },
        "to" : {
          "x" : 1133,
          "y" : 695
        }
      }, {
        "from" : {
          "x" : 1133,
          "y" : 695
        },
        "to" : {
          "x" : 1686,
          "y" : 629
        }
      }, {
        "from" : {
          "x" : 1686,
          "y" : 629
        },
        "to" : {
          "x" : 1752,
          "y" : 857
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1100,
          "y" : 809
        },
        "b" : {
          "x" : 1102,
          "y" : 817
        },
        "c" : {
          "x" : 1108,
          "y" : 811
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1108,
          "y" : 811
        }
      }
    }, {
      "edgeId" : 599,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1145,
          "y" : 817
        },
        "to" : {
          "x" : 1182,
          "y" : 799
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 800,
    "reactomeId" : 5362546,
    "displayName" : "Hh-Np:GPC5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1601,
      "y" : 49
    },
    "isFadeOut" : true,
    "minX" : 1560,
    "maxX" : 1643,
    "minY" : 33,
    "maxY" : 66,
    "prop" : {
      "x" : 1560,
      "y" : 33,
      "width" : 83,
      "height" : 33
    },
    "textPosition" : {
      "x" : 1560,
      "y" : 45
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 799,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 801,
    "reactomeId" : 5362370,
    "displayName" : "NOTUM",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1653,
      "y" : 111
    },
    "isFadeOut" : true,
    "minX" : 1570,
    "maxX" : 1696,
    "minY" : 98,
    "maxY" : 124,
    "prop" : {
      "x" : 1610,
      "y" : 98,
      "width" : 86,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1627,
      "y" : 100
    },
    "connectors" : [ {
      "edgeId" : 799,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1607,
          "y" : 108
        },
        "to" : {
          "x" : 1578,
          "y" : 106
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1574,
          "y" : 106
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1574,
          "y" : 106
        }
      }
    } ]
  }, {
    "id" : 618,
    "reactomeId" : 113595,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1424,
      "y" : 924
    },
    "isFadeOut" : true,
    "minX" : 1391,
    "maxX" : 1457,
    "minY" : 845,
    "maxY" : 938,
    "prop" : {
      "x" : 1391,
      "y" : 911,
      "width" : 66,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1411,
      "y" : 914
    },
    "connectors" : [ {
      "edgeId" : 617,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1420,
          "y" : 905
        },
        "to" : {
          "x" : 1402,
          "y" : 845
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 634,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 619,
    "reactomeId" : 5362408,
    "displayName" : "ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1537,
      "y" : 838
    },
    "isFadeOut" : true,
    "minX" : 1470,
    "maxX" : 1671,
    "minY" : 798,
    "maxY" : 879,
    "prop" : {
      "x" : 1470,
      "y" : 798,
      "width" : 134,
      "height" : 81
    },
    "textPosition" : {
      "x" : 1472,
      "y" : 802
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 617,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 623,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1607,
          "y" : 845
        },
        "to" : {
          "x" : 1614,
          "y" : 847
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 623,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1607,
          "y" : 808
        },
        "to" : {
          "x" : 1610,
          "y" : 806
        }
      }, {
        "from" : {
          "x" : 1610,
          "y" : 806
        },
        "to" : {
          "x" : 1663,
          "y" : 848
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1667,
          "y" : 851
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1667,
          "y" : 851
        }
      }
    } ]
  }, {
    "id" : 624,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1686,
      "y" : 912
    },
    "isFadeOut" : true,
    "minX" : 1614,
    "maxX" : 1706,
    "minY" : 847,
    "maxY" : 927,
    "prop" : {
      "x" : 1666,
      "y" : 897,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1669,
      "y" : 901
    },
    "connectors" : [ {
      "edgeId" : 623,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1669,
          "y" : 894
        },
        "to" : {
          "x" : 1614,
          "y" : 847
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 1635,
            "y" : 864
          },
          "b" : {
            "x" : 1647,
            "y" : 876
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1641,
            "y" : 870
          }
        }
      }
    } ]
  }, {
    "id" : 625,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1622,
      "y" : 910
    },
    "isFadeOut" : true,
    "minX" : 1602,
    "maxX" : 1642,
    "minY" : 847,
    "maxY" : 925,
    "prop" : {
      "x" : 1602,
      "y" : 895,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1606,
      "y" : 899
    },
    "connectors" : [ {
      "edgeId" : 623,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1620,
          "y" : 892
        },
        "to" : {
          "x" : 1614,
          "y" : 847
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 1611,
            "y" : 863
          },
          "b" : {
            "x" : 1623,
            "y" : 875
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1617,
            "y" : 869
          }
        }
      }
    } ]
  }, {
    "id" : 626,
    "reactomeId" : 1132287,
    "displayName" : "phosphate",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1892,
      "y" : 897
    },
    "isFadeOut" : true,
    "minX" : 1752,
    "maxX" : 1934,
    "minY" : 857,
    "maxY" : 912,
    "prop" : {
      "x" : 1850,
      "y" : 882,
      "width" : 84,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1854,
      "y" : 886
    },
    "connectors" : [ {
      "edgeId" : 623,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1847,
          "y" : 885
        },
        "to" : {
          "x" : 1752,
          "y" : 857
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 1793,
            "y" : 865
          },
          "b" : {
            "x" : 1805,
            "y" : 877
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1799,
            "y" : 871
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1839,
          "y" : 887
        },
        "b" : {
          "x" : 1847,
          "y" : 885
        },
        "c" : {
          "x" : 1841,
          "y" : 879
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1841,
          "y" : 879
        }
      }
    } ]
  }, {
    "id" : 951,
    "reactomeId" : 5490380,
    "displayName" : "NglycoAsn-Hh precursors:P4HB",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 490,
      "y" : 686
    },
    "isFadeOut" : true,
    "minX" : 437,
    "maxX" : 632,
    "minY" : 668,
    "maxY" : 761,
    "prop" : {
      "x" : 437,
      "y" : 668,
      "width" : 106,
      "height" : 36
    },
    "textPosition" : {
      "x" : 441,
      "y" : 655
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 3,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 7,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 536,
          "y" : 707
        },
        "to" : {
          "x" : 608,
          "y" : 732
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 7,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 510,
          "y" : 707
        },
        "to" : {
          "x" : 575,
          "y" : 760
        }
      }, {
        "from" : {
          "x" : 575,
          "y" : 760
        },
        "to" : {
          "x" : 624,
          "y" : 757
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 628,
          "y" : 757
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 628,
          "y" : 757
        }
      }
    } ]
  }, {
    "id" : 631,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1776,
      "y" : 920
    },
    "isFadeOut" : true,
    "minX" : 1752,
    "maxX" : 1797,
    "minY" : 857,
    "maxY" : 935,
    "prop" : {
      "x" : 1755,
      "y" : 905,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1759,
      "y" : 909
    },
    "connectors" : [ {
      "edgeId" : 623,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1770,
          "y" : 902
        },
        "to" : {
          "x" : 1752,
          "y" : 857
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 1755,
            "y" : 873
          },
          "b" : {
            "x" : 1767,
            "y" : 885
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1761,
            "y" : 879
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1764,
          "y" : 897
        },
        "b" : {
          "x" : 1770,
          "y" : 902
        },
        "c" : {
          "x" : 1771,
          "y" : 894
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1771,
          "y" : 894
        }
      }
    } ]
  }, {
    "id" : 632,
    "reactomeId" : 5362391,
    "displayName" : "ub C-terminal Hh fragments",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2028,
      "y" : 852
    },
    "isFadeOut" : true,
    "minX" : 1752,
    "maxX" : 2089,
    "minY" : 834,
    "maxY" : 870,
    "prop" : {
      "x" : 1968,
      "y" : 834,
      "width" : 121,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1970,
      "y" : 834
    },
    "connectors" : [ {
      "edgeId" : 623,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1962,
          "y" : 853
        },
        "to" : {
          "x" : 1752,
          "y" : 857
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1955,
          "y" : 857
        },
        "b" : {
          "x" : 1962,
          "y" : 853
        },
        "c" : {
          "x" : 1955,
          "y" : 849
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1955,
          "y" : 849
        }
      }
    }, {
      "edgeId" : 634,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 635,
    "reactomeId" : 68819,
    "displayName" : "26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1918,
      "y" : 1023
    },
    "isFadeOut" : true,
    "minX" : 1870,
    "maxX" : 1969,
    "minY" : 941,
    "maxY" : 1043,
    "prop" : {
      "x" : 1870,
      "y" : 1003,
      "width" : 97,
      "height" : 40
    },
    "textPosition" : {
      "x" : 1876,
      "y" : 1008
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 634,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1930,
          "y" : 1000
        },
        "to" : {
          "x" : 1962,
          "y" : 949
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1965,
          "y" : 945
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1965,
          "y" : 945
        }
      }
    } ]
  }, {
    "id" : 828,
    "reactomeId" : 5362783,
    "displayName" : "Hh-Npp",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1078,
      "y" : 46
    },
    "isFadeOut" : true,
    "minX" : 1040,
    "maxX" : 1116,
    "minY" : 30,
    "maxY" : 62,
    "prop" : {
      "x" : 1040,
      "y" : 30,
      "width" : 76,
      "height" : 32
    },
    "textPosition" : {
      "x" : 1051,
      "y" : 35
    },
    "connectors" : [ {
      "edgeId" : 827,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 829,
    "reactomeId" : 179878,
    "displayName" : "ADAM17",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1154,
      "y" : 146
    },
    "isFadeOut" : true,
    "minX" : 1086,
    "maxX" : 1195,
    "minY" : 115,
    "maxY" : 160,
    "prop" : {
      "x" : 1113,
      "y" : 132,
      "width" : 82,
      "height" : 28
    },
    "textPosition" : {
      "x" : 1124,
      "y" : 135
    },
    "connectors" : [ {
      "edgeId" : 827,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1120,
          "y" : 129
        },
        "to" : {
          "x" : 1094,
          "y" : 120
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1090,
          "y" : 119
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1090,
          "y" : 119
        }
      }
    } ]
  }, {
    "id" : 154109,
    "reactomeId" : 5483226,
    "displayName" : "HHAT G287V",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 917,
      "y" : 413
    },
    "isDisease" : true,
    "minX" : 884,
    "maxX" : 956,
    "minY" : 394,
    "maxY" : 554,
    "prop" : {
      "x" : 884,
      "y" : 400,
      "width" : 66,
      "height" : 26
    },
    "textPosition" : {
      "x" : 892,
      "y" : 396
    },
    "needDashedBorder" : true,
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 950,
          "y" : 400
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 950,
          "y" : 400
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 154108,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 916,
          "y" : 429
        },
        "to" : {
          "x" : 912,
          "y" : 546
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 912,
          "y" : 550
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 912,
          "y" : 550
        }
      },
      "isDisease" : true
    } ]
  } ],
  "edges" : [ {
    "id" : 3,
    "reactomeId" : 5358336,
    "displayName" : "P4HB forms mixed disulphides with Hh precursors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 404,
      "y" : 745
    },
    "isFadeOut" : true,
    "minX" : 380,
    "maxX" : 463,
    "minY" : 707,
    "maxY" : 761,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 380,
        "y" : 761
      },
      "to" : {
        "x" : 404,
        "y" : 745
      }
    }, {
      "from" : {
        "x" : 404,
        "y" : 745
      },
      "to" : {
        "x" : 463,
        "y" : 707
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 459,
        "y" : 714
      },
      "b" : {
        "x" : 463,
        "y" : 707
      },
      "c" : {
        "x" : 455,
        "y" : 707
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 455,
        "y" : 707
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 404,
        "y" : 745
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 404,
        "y" : 745
      }
    },
    "inputs" : [ {
      "id" : 5,
      "points" : [ {
        "x" : 327,
        "y" : 698
      } ]
    }, {
      "id" : 579,
      "points" : [ {
        "x" : 362,
        "y" : 762
      } ]
    } ],
    "outputs" : [ {
      "id" : 951
    } ]
  }, {
    "id" : 581,
    "reactomeId" : 5362386,
    "displayName" : "Glycosylation of Hh",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 230,
      "y" : 766
    },
    "isFadeOut" : true,
    "minX" : 215,
    "maxX" : 255,
    "minY" : 760,
    "maxY" : 772,
    "reactionType" : "Omitted Process",
    "segments" : [ {
      "from" : {
        "x" : 215,
        "y" : 766
      },
      "to" : {
        "x" : 230,
        "y" : 766
      }
    }, {
      "from" : {
        "x" : 230,
        "y" : 766
      },
      "to" : {
        "x" : 255,
        "y" : 765
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 248,
        "y" : 769
      },
      "b" : {
        "x" : 255,
        "y" : 765
      },
      "c" : {
        "x" : 248,
        "y" : 761
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 248,
        "y" : 761
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 224,
        "y" : 760
      },
      "b" : {
        "x" : 236,
        "y" : 772
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 230,
        "y" : 766
      }
    },
    "inputs" : [ {
      "id" : 4
    } ],
    "outputs" : [ {
      "id" : 579
    } ]
  }, {
    "id" : 7,
    "reactomeId" : 5358340,
    "displayName" : "Autoproteolytic cleavage of Hh precursors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 640,
      "y" : 756
    },
    "isFadeOut" : true,
    "minX" : 608,
    "maxX" : 661,
    "minY" : 732,
    "maxY" : 762,
    "segments" : [ {
      "from" : {
        "x" : 608,
        "y" : 732
      },
      "to" : {
        "x" : 640,
        "y" : 756
      }
    }, {
      "from" : {
        "x" : 640,
        "y" : 756
      },
      "to" : {
        "x" : 661,
        "y" : 753
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 634,
        "y" : 750
      },
      "b" : {
        "x" : 646,
        "y" : 762
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 640,
        "y" : 756
      }
    },
    "inputs" : [ {
      "id" : 951,
      "points" : [ {
        "x" : 536,
        "y" : 707
      } ]
    }, {
      "id" : 8,
      "points" : [ {
        "x" : 580,
        "y" : 668
      } ]
    } ],
    "outputs" : [ {
      "id" : 5,
      "points" : [ {
        "x" : 337,
        "y" : 656
      }, {
        "x" : 393,
        "y" : 618
      }, {
        "x" : 614,
        "y" : 617
      } ]
    }, {
      "id" : 9,
      "points" : [ {
        "x" : 757,
        "y" : 587
      } ]
    }, {
      "id" : 10,
      "points" : [ {
        "x" : 709,
        "y" : 753
      } ]
    } ],
    "catalysts" : [ {
      "id" : 951,
      "points" : [ {
        "x" : 510,
        "y" : 707
      }, {
        "x" : 575,
        "y" : 760
      } ]
    } ]
  }, {
    "id" : 648,
    "reactomeId" : 5362549,
    "displayName" : "Hh-Np traffics to the plasma membrane",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1081,
      "y" : 419
    },
    "isFadeOut" : true,
    "minX" : 1075,
    "maxX" : 1087,
    "minY" : 192,
    "maxY" : 540,
    "reactionType" : "Omitted Process",
    "segments" : [ {
      "from" : {
        "x" : 1080,
        "y" : 540
      },
      "to" : {
        "x" : 1081,
        "y" : 419
      }
    }, {
      "from" : {
        "x" : 1081,
        "y" : 419
      },
      "to" : {
        "x" : 1079,
        "y" : 192
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1083,
        "y" : 199
      },
      "b" : {
        "x" : 1079,
        "y" : 192
      },
      "c" : {
        "x" : 1075,
        "y" : 199
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1075,
        "y" : 199
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1075,
        "y" : 413
      },
      "b" : {
        "x" : 1087,
        "y" : 425
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1081,
        "y" : 419
      }
    },
    "inputs" : [ {
      "id" : 14
    } ],
    "outputs" : [ {
      "id" : 655
    } ]
  }, {
    "id" : 617,
    "reactomeId" : 5362412,
    "displayName" : "SYVN1 ubiquitinates Hh C-terminal fragments",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1419,
      "y" : 841
    },
    "isFadeOut" : true,
    "minX" : 1402,
    "maxX" : 1467,
    "minY" : 835,
    "maxY" : 847,
    "segments" : [ {
      "from" : {
        "x" : 1402,
        "y" : 845
      },
      "to" : {
        "x" : 1419,
        "y" : 841
      }
    }, {
      "from" : {
        "x" : 1419,
        "y" : 841
      },
      "to" : {
        "x" : 1467,
        "y" : 839
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1460,
        "y" : 843
      },
      "b" : {
        "x" : 1467,
        "y" : 839
      },
      "c" : {
        "x" : 1460,
        "y" : 835
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1460,
        "y" : 835
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1413,
        "y" : 835
      },
      "b" : {
        "x" : 1425,
        "y" : 847
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1419,
        "y" : 841
      }
    },
    "inputs" : [ {
      "id" : 602,
      "points" : [ {
        "x" : 1390,
        "y" : 844
      } ]
    }, {
      "id" : 618,
      "points" : [ {
        "x" : 1420,
        "y" : 905
      } ]
    } ],
    "outputs" : [ {
      "id" : 619
    } ],
    "catalysts" : [ {
      "id" : 602,
      "points" : [ {
        "x" : 1369,
        "y" : 799
      }, {
        "x" : 1386,
        "y" : 790
      } ]
    } ]
  }, {
    "id" : 587,
    "reactomeId" : 5362437,
    "displayName" : "C-terminal Hh fragments are bound by lectins",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 877,
      "y" : 731
    },
    "isFadeOut" : true,
    "minX" : 855,
    "maxX" : 910,
    "minY" : 726,
    "maxY" : 736,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 855,
        "y" : 731
      },
      "to" : {
        "x" : 877,
        "y" : 731
      }
    }, {
      "from" : {
        "x" : 877,
        "y" : 731
      },
      "to" : {
        "x" : 910,
        "y" : 731
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 903,
        "y" : 735
      },
      "b" : {
        "x" : 910,
        "y" : 731
      },
      "c" : {
        "x" : 903,
        "y" : 727
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 903,
        "y" : 727
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 877,
        "y" : 731
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 877,
        "y" : 731
      }
    },
    "inputs" : [ {
      "id" : 588,
      "points" : [ {
        "x" : 827,
        "y" : 700
      } ]
    }, {
      "id" : 10,
      "points" : [ {
        "x" : 821,
        "y" : 740
      } ]
    } ],
    "outputs" : [ {
      "id" : 589
    } ]
  }, {
    "id" : 11,
    "reactomeId" : 5358343,
    "displayName" : "HHAT palmitoylates Hh N-terminal fragment",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 912,
      "y" : 562
    },
    "isFadeOut" : true,
    "minX" : 872,
    "maxX" : 943,
    "minY" : 556,
    "maxY" : 568,
    "segments" : [ {
      "from" : {
        "x" : 872,
        "y" : 561
      },
      "to" : {
        "x" : 912,
        "y" : 562
      }
    }, {
      "from" : {
        "x" : 912,
        "y" : 562
      },
      "to" : {
        "x" : 943,
        "y" : 563
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 906,
        "y" : 556
      },
      "b" : {
        "x" : 918,
        "y" : 568
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 912,
        "y" : 562
      }
    },
    "inputs" : [ {
      "id" : 9,
      "points" : [ {
        "x" : 835,
        "y" : 561
      } ]
    }, {
      "id" : 12,
      "points" : [ {
        "x" : 837,
        "y" : 517
      } ]
    } ],
    "outputs" : [ {
      "id" : 13,
      "points" : [ {
        "x" : 966,
        "y" : 518
      } ]
    }, {
      "id" : 14,
      "points" : [ {
        "x" : 1044,
        "y" : 560
      } ]
    } ],
    "catalysts" : [ {
      "id" : 15,
      "points" : [ {
        "x" : 916,
        "y" : 429
      } ]
    } ]
  }, {
    "id" : 623,
    "reactomeId" : 5362459,
    "displayName" : "VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1676,
      "y" : 858
    },
    "isFadeOut" : true,
    "minX" : 1614,
    "maxX" : 1752,
    "minY" : 847,
    "maxY" : 864,
    "segments" : [ {
      "from" : {
        "x" : 1614,
        "y" : 847
      },
      "to" : {
        "x" : 1676,
        "y" : 858
      }
    }, {
      "from" : {
        "x" : 1676,
        "y" : 858
      },
      "to" : {
        "x" : 1752,
        "y" : 857
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1670,
        "y" : 852
      },
      "b" : {
        "x" : 1682,
        "y" : 864
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1676,
        "y" : 858
      }
    },
    "inputs" : [ {
      "id" : 624,
      "points" : [ {
        "x" : 1669,
        "y" : 894
      } ],
      "stoichiometry" : 6
    }, {
      "id" : 625,
      "points" : [ {
        "x" : 1620,
        "y" : 892
      } ],
      "stoichiometry" : 6
    }, {
      "id" : 619,
      "points" : [ {
        "x" : 1607,
        "y" : 845
      } ]
    } ],
    "outputs" : [ {
      "id" : 626,
      "points" : [ {
        "x" : 1847,
        "y" : 885
      } ],
      "stoichiometry" : 6
    }, {
      "id" : 603,
      "points" : [ {
        "x" : 1102,
        "y" : 817
      }, {
        "x" : 1133,
        "y" : 695
      }, {
        "x" : 1686,
        "y" : 629
      } ]
    }, {
      "id" : 588,
      "points" : [ {
        "x" : 876,
        "y" : 674
      }, {
        "x" : 1722,
        "y" : 593
      } ]
    }, {
      "id" : 631,
      "points" : [ {
        "x" : 1770,
        "y" : 902
      } ],
      "stoichiometry" : 6
    }, {
      "id" : 632,
      "points" : [ {
        "x" : 1962,
        "y" : 853
      } ]
    } ],
    "catalysts" : [ {
      "id" : 619,
      "points" : [ {
        "x" : 1607,
        "y" : 808
      }, {
        "x" : 1610,
        "y" : 806
      } ]
    } ]
  }, {
    "id" : 656,
    "reactomeId" : 5362422,
    "displayName" : "Hh-Np binds to DISP2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 907,
      "y" : 174
    },
    "isFadeOut" : true,
    "minX" : 845,
    "maxX" : 954,
    "minY" : 169,
    "maxY" : 179,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 954,
        "y" : 174
      },
      "to" : {
        "x" : 907,
        "y" : 174
      }
    }, {
      "from" : {
        "x" : 907,
        "y" : 174
      },
      "to" : {
        "x" : 845,
        "y" : 174
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 852,
        "y" : 170
      },
      "b" : {
        "x" : 845,
        "y" : 174
      },
      "c" : {
        "x" : 852,
        "y" : 178
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 852,
        "y" : 178
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 907,
        "y" : 174
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 907,
        "y" : 174
      }
    },
    "inputs" : [ {
      "id" : 649,
      "points" : [ {
        "x" : 964,
        "y" : 162
      } ]
    }, {
      "id" : 655,
      "points" : [ {
        "x" : 1049,
        "y" : 174
      } ]
    } ],
    "outputs" : [ {
      "id" : 650
    } ]
  }, {
    "id" : 657,
    "reactomeId" : 5362551,
    "displayName" : "Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 806,
      "y" : 77
    },
    "isFadeOut" : true,
    "minX" : 801,
    "maxX" : 811,
    "minY" : 58,
    "maxY" : 95,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 805,
        "y" : 95
      },
      "to" : {
        "x" : 806,
        "y" : 77
      }
    }, {
      "from" : {
        "x" : 806,
        "y" : 77
      },
      "to" : {
        "x" : 806,
        "y" : 58
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 806,
        "y" : 77
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 806,
        "y" : 77
      }
    },
    "inputs" : [ {
      "id" : 658,
      "points" : [ {
        "x" : 768,
        "y" : 108
      } ]
    }, {
      "id" : 650,
      "points" : [ {
        "x" : 805,
        "y" : 150
      } ]
    } ],
    "outputs" : [ {
      "id" : 649,
      "points" : [ {
        "x" : 948,
        "y" : 130
      } ]
    }, {
      "id" : 659,
      "points" : [ {
        "x" : 806,
        "y" : 35
      } ]
    } ]
  }, {
    "id" : 786,
    "reactomeId" : 5362427,
    "displayName" : "Hh-Np binds GPC5",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1391,
      "y" : 174
    },
    "isFadeOut" : true,
    "minX" : 1366,
    "maxX" : 1458,
    "minY" : 169,
    "maxY" : 179,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 1366,
        "y" : 175
      },
      "to" : {
        "x" : 1391,
        "y" : 174
      }
    }, {
      "from" : {
        "x" : 1391,
        "y" : 174
      },
      "to" : {
        "x" : 1458,
        "y" : 173
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1451,
        "y" : 177
      },
      "b" : {
        "x" : 1458,
        "y" : 173
      },
      "c" : {
        "x" : 1451,
        "y" : 169
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1451,
        "y" : 169
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1391,
        "y" : 174
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1391,
        "y" : 174
      }
    },
    "inputs" : [ {
      "id" : 655,
      "points" : [ {
        "x" : 1110,
        "y" : 175
      } ]
    }, {
      "id" : 787,
      "points" : [ {
        "x" : 1354,
        "y" : 162
      } ]
    } ],
    "outputs" : [ {
      "id" : 788
    } ]
  }, {
    "id" : 599,
    "reactomeId" : 5362441,
    "displayName" : "C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1203,
      "y" : 804
    },
    "isFadeOut" : true,
    "minX" : 1182,
    "maxX" : 1238,
    "minY" : 799,
    "maxY" : 816,
    "reactionType" : "Association",
    "segments" : [ {
      "from" : {
        "x" : 1182,
        "y" : 799
      },
      "to" : {
        "x" : 1203,
        "y" : 804
      }
    }, {
      "from" : {
        "x" : 1203,
        "y" : 804
      },
      "to" : {
        "x" : 1238,
        "y" : 816
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1230,
        "y" : 818
      },
      "b" : {
        "x" : 1238,
        "y" : 816
      },
      "c" : {
        "x" : 1233,
        "y" : 810
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1233,
        "y" : 810
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1203,
        "y" : 804
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1203,
        "y" : 804
      }
    },
    "inputs" : [ {
      "id" : 603,
      "points" : [ {
        "x" : 1145,
        "y" : 817
      } ]
    }, {
      "id" : 589,
      "points" : [ {
        "x" : 1055,
        "y" : 754
      } ]
    } ],
    "outputs" : [ {
      "id" : 602
    } ]
  }, {
    "id" : 634,
    "reactomeId" : 5362448,
    "displayName" : "Hh C-terminal fragments are degraded by the proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1971,
      "y" : 935
    },
    "isFadeOut" : true,
    "minX" : 1463,
    "maxX" : 2015,
    "minY" : 876,
    "maxY" : 949,
    "reactionType" : "Omitted Process",
    "segments" : [ {
      "from" : {
        "x" : 2015,
        "y" : 876
      },
      "to" : {
        "x" : 1971,
        "y" : 935
      }
    }, {
      "from" : {
        "x" : 1971,
        "y" : 935
      },
      "to" : {
        "x" : 1898,
        "y" : 949
      }
    }, {
      "from" : {
        "x" : 1898,
        "y" : 949
      },
      "to" : {
        "x" : 1463,
        "y" : 925
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1470,
        "y" : 921
      },
      "b" : {
        "x" : 1463,
        "y" : 925
      },
      "c" : {
        "x" : 1470,
        "y" : 929
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1470,
        "y" : 929
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1965,
        "y" : 929
      },
      "b" : {
        "x" : 1977,
        "y" : 941
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1971,
        "y" : 935
      }
    },
    "inputs" : [ {
      "id" : 632
    } ],
    "outputs" : [ {
      "id" : 618
    } ],
    "catalysts" : [ {
      "id" : 635,
      "points" : [ {
        "x" : 1930,
        "y" : 1000
      } ]
    } ]
  }, {
    "id" : 827,
    "reactomeId" : 5362793,
    "displayName" : "Hh-Np is cleaved by ADAM17 to promote ligand shedding",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1079,
      "y" : 115
    },
    "isFadeOut" : true,
    "minX" : 1073,
    "maxX" : 1085,
    "minY" : 68,
    "maxY" : 158,
    "segments" : [ {
      "from" : {
        "x" : 1079,
        "y" : 158
      },
      "to" : {
        "x" : 1079,
        "y" : 115
      }
    }, {
      "from" : {
        "x" : 1079,
        "y" : 115
      },
      "to" : {
        "x" : 1078,
        "y" : 68
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1082,
        "y" : 75
      },
      "b" : {
        "x" : 1078,
        "y" : 68
      },
      "c" : {
        "x" : 1074,
        "y" : 75
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1074,
        "y" : 75
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1073,
        "y" : 109
      },
      "b" : {
        "x" : 1085,
        "y" : 121
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1079,
        "y" : 115
      }
    },
    "inputs" : [ {
      "id" : 655
    } ],
    "outputs" : [ {
      "id" : 828
    } ],
    "catalysts" : [ {
      "id" : 829,
      "points" : [ {
        "x" : 1120,
        "y" : 129
      } ]
    } ]
  }, {
    "id" : 154108,
    "reactomeId" : 5483229,
    "displayName" : "HHAT G287V doesn't palmitoylate Hh-Np",
    "schemaClass" : "FailedReaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 912,
      "y" : 562
    },
    "isDisease" : true,
    "minX" : 872,
    "maxX" : 943,
    "minY" : 556,
    "maxY" : 568,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 872,
        "y" : 561
      },
      "to" : {
        "x" : 912,
        "y" : 562
      }
    }, {
      "from" : {
        "x" : 912,
        "y" : 562
      },
      "to" : {
        "x" : 943,
        "y" : 563
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 906,
        "y" : 556
      },
      "b" : {
        "x" : 918,
        "y" : 568
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 912,
        "y" : 562
      }
    },
    "inputs" : [ {
      "id" : 9,
      "points" : [ {
        "x" : 835,
        "y" : 561
      } ]
    }, {
      "id" : 12,
      "points" : [ {
        "x" : 837,
        "y" : 517
      } ]
    } ],
    "outputs" : [ {
      "id" : 13,
      "points" : [ {
        "x" : 966,
        "y" : 518
      } ]
    }, {
      "id" : 14,
      "points" : [ {
        "x" : 1044,
        "y" : 560
      } ]
    } ],
    "catalysts" : [ {
      "id" : 154109,
      "points" : [ {
        "x" : 916,
        "y" : 429
      } ]
    } ]
  }, {
    "id" : 799,
    "reactomeId" : 5362553,
    "displayName" : "NOTUM releases Hh-Np:GPC5 from the plasma membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1562,
      "y" : 105
    },
    "isFadeOut" : true,
    "minX" : 1520,
    "maxX" : 1589,
    "minY" : 69,
    "maxY" : 147,
    "segments" : [ {
      "from" : {
        "x" : 1520,
        "y" : 147
      },
      "to" : {
        "x" : 1562,
        "y" : 105
      }
    }, {
      "from" : {
        "x" : 1562,
        "y" : 105
      },
      "to" : {
        "x" : 1589,
        "y" : 69
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1588,
        "y" : 77
      },
      "b" : {
        "x" : 1589,
        "y" : 69
      },
      "c" : {
        "x" : 1582,
        "y" : 72
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1582,
        "y" : 72
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1556,
        "y" : 99
      },
      "b" : {
        "x" : 1568,
        "y" : 111
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1562,
        "y" : 105
      }
    },
    "inputs" : [ {
      "id" : 788
    } ],
    "outputs" : [ {
      "id" : 800
    } ],
    "catalysts" : [ {
      "id" : 801,
      "points" : [ {
        "x" : 1607,
        "y" : 108
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 2,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 939,
      "y" : 635
    },
    "minX" : 71,
    "maxX" : 1807,
    "minY" : 403,
    "maxY" : 868,
    "prop" : {
      "x" : 71,
      "y" : 403,
      "width" : 1736,
      "height" : 465
    },
    "textPosition" : {
      "x" : 382,
      "y" : 562
    },
    "insets" : {
      "x" : 84,
      "y" : 425,
      "width" : 1688,
      "height" : 429
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 3, 4, 5, 10, 7, 8, 13, 14, 12, 9, 11, 579, 581, 587, 588, 589, 599, 602, 603, 617, 619, 623, 15, 887, 888, 890, 648, 944, 951, 1152, 1153, 1154 ]
  }, {
    "id" : 646,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1132,
      "y" : 620
    },
    "minX" : 0,
    "maxX" : 2264,
    "minY" : 148,
    "maxY" : 1092,
    "prop" : {
      "x" : 0,
      "y" : 148,
      "width" : 2264,
      "height" : 944
    },
    "textPosition" : {
      "x" : 698,
      "y" : 359
    },
    "insets" : {
      "x" : 37,
      "y" : 183,
      "width" : 2198,
      "height" : 879
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 618, 624, 625, 626, 631, 632, 634, 635, 2, 649, 650, 655, 656, 786, 788, 787, 829, 895, 1159, 1157, 1156, 1158, 1155 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 2264,
  "minY" : 0,
  "maxY" : 1092,
  "disease" : true
}