{
  "dbId" : 5654736,
  "stableId" : "R-HSA-5654736",
  "displayName" : "Signaling by FGFR1",
  "forNormalDraw" : true,
  "nodes" : [ {
    "id" : 2561,
    "reactomeId" : 113595,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 6080,
      "y" : 1732
    },
    "minX" : 6051,
    "maxX" : 6218,
    "minY" : 1722,
    "maxY" : 1743,
    "prop" : {
      "x" : 6051,
      "y" : 1722,
      "width" : 58,
      "height" : 21
    },
    "textPosition" : {
      "x" : 6067,
      "y" : 1722
    },
    "connectors" : [ {
      "edgeId" : 2523,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6115,
          "y" : 1733
        },
        "to" : {
          "x" : 6218,
          "y" : 1737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13060,
    "reactomeId" : 5654348,
    "displayName" : "FGFRL1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 352,
      "y" : 1918
    },
    "minX" : 300,
    "maxX" : 791,
    "minY" : 1890,
    "maxY" : 1998,
    "prop" : {
      "x" : 300,
      "y" : 1896,
      "width" : 104,
      "height" : 44
    },
    "textPosition" : {
      "x" : 306,
      "y" : 1919
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 404,
          "y" : 1896
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 404,
          "y" : 1896
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13067,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 351,
          "y" : 1943
        },
        "to" : {
          "x" : 351,
          "y" : 1998
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 13113,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 407,
          "y" : 1924
        },
        "to" : {
          "x" : 791,
          "y" : 1969
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13061,
    "reactomeId" : 5654351,
    "displayName" : "FGFRL1-binding FGFs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 170,
      "y" : 1877
    },
    "minX" : 117,
    "maxX" : 351,
    "minY" : 1859,
    "maxY" : 1998,
    "prop" : {
      "x" : 117,
      "y" : 1859,
      "width" : 107,
      "height" : 36
    },
    "textPosition" : {
      "x" : 117,
      "y" : 1859
    },
    "connectors" : [ {
      "edgeId" : 13067,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 196,
          "y" : 1901
        },
        "to" : {
          "x" : 351,
          "y" : 1998
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 267,
            "y" : 1943
          },
          "b" : {
            "x" : 279,
            "y" : 1955
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 273,
            "y" : 1949
          }
        }
      }
    } ]
  }, {
    "id" : 13064,
    "reactomeId" : 5654354,
    "displayName" : "FGFRL1-binding FGFs:FGFRL1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 353,
      "y" : 2127
    },
    "minX" : 290,
    "maxX" : 423,
    "minY" : 2097,
    "maxY" : 2152,
    "prop" : {
      "x" : 290,
      "y" : 2103,
      "width" : 127,
      "height" : 49
    },
    "textPosition" : {
      "x" : 290,
      "y" : 2117
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 417,
          "y" : 2103
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 417,
          "y" : 2103
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13067,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2568,
    "reactomeId" : 934550,
    "displayName" : "PP2A(A:C):SPRY2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6225,
      "y" : 850
    },
    "minX" : 5911,
    "maxX" : 6281,
    "minY" : 825,
    "maxY" : 960,
    "prop" : {
      "x" : 6176,
      "y" : 831,
      "width" : 99,
      "height" : 39
    },
    "textPosition" : {
      "x" : 6188,
      "y" : 835
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6275,
          "y" : 831
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6275,
          "y" : 831
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2601,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6223,
          "y" : 873
        },
        "to" : {
          "x" : 6216,
          "y" : 960
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2550,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6173,
          "y" : 864
        },
        "to" : {
          "x" : 5911,
          "y" : 941
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2555,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1545,
    "reactomeId" : 167679,
    "displayName" : "p-4Y-PLCG1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1476,
      "y" : 189
    },
    "minX" : 1426,
    "maxX" : 1576,
    "minY" : 141,
    "maxY" : 216,
    "prop" : {
      "x" : 1426,
      "y" : 163,
      "width" : 100,
      "height" : 53
    },
    "innerProp" : {
      "x" : 1426,
      "y" : 169,
      "width" : 100,
      "height" : 47
    },
    "textPosition" : {
      "x" : 1437,
      "y" : 179
    },
    "nodeAttachments" : [ {
      "reactomeId" : 167675,
      "label" : "P",
      "description" : "O4'-phospho-L-tyrosine at 771",
      "shape" : {
        "a" : {
          "x" : 1436,
          "y" : 157
        },
        "b" : {
          "x" : 1448,
          "y" : 169
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1442,
          "y" : 163
        }
      }
    }, {
      "reactomeId" : 191478,
      "label" : "P",
      "description" : "O4'-phospho-L-tyrosine at 783",
      "shape" : {
        "a" : {
          "x" : 1452,
          "y" : 157
        },
        "b" : {
          "x" : 1464,
          "y" : 169
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1458,
          "y" : 163
        }
      }
    }, {
      "reactomeId" : 191469,
      "label" : "P",
      "description" : "O4'-phospho-L-tyrosine at 1253",
      "shape" : {
        "a" : {
          "x" : 1468,
          "y" : 157
        },
        "b" : {
          "x" : 1480,
          "y" : 169
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1474,
          "y" : 163
        }
      }
    }, {
      "reactomeId" : 213441,
      "label" : "P",
      "description" : "O4'-phospho-L-tyrosine at 472",
      "shape" : {
        "a" : {
          "x" : 1484,
          "y" : 157
        },
        "b" : {
          "x" : 1496,
          "y" : 169
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1490,
          "y" : 163
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1526,
          "y" : 163
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1526,
          "y" : 163
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8886,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1529,
          "y" : 165
        },
        "to" : {
          "x" : 1576,
          "y" : 141
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1533,
          "y" : 158
        },
        "b" : {
          "x" : 1529,
          "y" : 165
        },
        "c" : {
          "x" : 1537,
          "y" : 165
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1537,
          "y" : 165
        }
      }
    } ]
  }, {
    "id" : 13066,
    "reactomeId" : 190915,
    "displayName" : "HS",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 172,
      "y" : 1990
    },
    "minX" : 122,
    "maxX" : 351,
    "minY" : 1971,
    "maxY" : 2008,
    "prop" : {
      "x" : 122,
      "y" : 1972,
      "width" : 101,
      "height" : 36
    },
    "textPosition" : {
      "x" : 160,
      "y" : 1979
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 218,
          "y" : 1977
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 218,
          "y" : 1977
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13067,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 226,
          "y" : 1992
        },
        "to" : {
          "x" : 351,
          "y" : 1998
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2570,
    "reactomeId" : 1295593,
    "displayName" : "PPA2A(A:C):SPRY2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 5923,
      "y" : 876
    },
    "minX" : 5869,
    "maxX" : 5983,
    "minY" : 810,
    "maxY" : 894,
    "prop" : {
      "x" : 5869,
      "y" : 859,
      "width" : 108,
      "height" : 35
    },
    "textPosition" : {
      "x" : 5882,
      "y" : 859
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5977,
          "y" : 859
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5977,
          "y" : 859
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2593,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 5909,
          "y" : 856
        },
        "to" : {
          "x" : 5872,
          "y" : 810
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 5902,
          "y" : 853
        },
        "b" : {
          "x" : 5909,
          "y" : 856
        },
        "c" : {
          "x" : 5908,
          "y" : 848
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 5908,
          "y" : 848
        }
      }
    }, {
      "edgeId" : 2555,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2572,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 5825,
      "y" : 917
    },
    "minX" : 5797,
    "maxX" : 5911,
    "minY" : 905,
    "maxY" : 941,
    "prop" : {
      "x" : 5797,
      "y" : 906,
      "width" : 56,
      "height" : 23
    },
    "textPosition" : {
      "x" : 5809,
      "y" : 907
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5848,
          "y" : 911
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5848,
          "y" : 911
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2550,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 5856,
          "y" : 924
        },
        "to" : {
          "x" : 5911,
          "y" : 941
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 5877,
            "y" : 926
          },
          "b" : {
            "x" : 5889,
            "y" : 938
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 5883,
            "y" : 932
          }
        }
      }
    } ]
  }, {
    "id" : 2575,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 5999,
      "y" : 1220
    },
    "minX" : 5974,
    "maxX" : 6072,
    "minY" : 1195,
    "maxY" : 1231,
    "prop" : {
      "x" : 5974,
      "y" : 1210,
      "width" : 51,
      "height" : 21
    },
    "textPosition" : {
      "x" : 5983,
      "y" : 1210
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6020,
          "y" : 1215
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6020,
          "y" : 1215
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2550,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6028,
          "y" : 1211
        },
        "to" : {
          "x" : 6072,
          "y" : 1195
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 6044,
            "y" : 1197
          },
          "b" : {
            "x" : 6056,
            "y" : 1209
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 6050,
            "y" : 1203
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 6033,
          "y" : 1205
        },
        "b" : {
          "x" : 6028,
          "y" : 1211
        },
        "c" : {
          "x" : 6036,
          "y" : 1212
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6036,
          "y" : 1212
        }
      }
    } ]
  }, {
    "id" : 2319,
    "reactomeId" : 109796,
    "displayName" : "p21 RAS:GDP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3163,
      "y" : 786
    },
    "minX" : 3123,
    "maxX" : 3295,
    "minY" : 749,
    "maxY" : 815,
    "prop" : {
      "x" : 3123,
      "y" : 767,
      "width" : 80,
      "height" : 39
    },
    "textPosition" : {
      "x" : 3131,
      "y" : 771
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3203,
          "y" : 767
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3203,
          "y" : 767
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13847,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3206,
          "y" : 773
        },
        "to" : {
          "x" : 3278,
          "y" : 749
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8863,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3206,
          "y" : 794
        },
        "to" : {
          "x" : 3295,
          "y" : 815
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8895,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3206,
          "y" : 784
        },
        "to" : {
          "x" : 3288,
          "y" : 781
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2576,
    "reactomeId" : 934598,
    "displayName" : "PP2A(A:C):Y55/Y227-pSPRY2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6234,
      "y" : 1210
    },
    "minX" : 6052,
    "maxX" : 6316,
    "minY" : 1187,
    "maxY" : 1519,
    "prop" : {
      "x" : 6159,
      "y" : 1193,
      "width" : 151,
      "height" : 35
    },
    "textPosition" : {
      "x" : 6166,
      "y" : 1193
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6310,
          "y" : 1193
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6310,
          "y" : 1193
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2514,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6234,
          "y" : 1231
        },
        "to" : {
          "x" : 6234,
          "y" : 1265
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2521,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6269,
          "y" : 1231
        },
        "to" : {
          "x" : 6308,
          "y" : 1246
        }
      }, {
        "from" : {
          "x" : 6308,
          "y" : 1246
        },
        "to" : {
          "x" : 6305,
          "y" : 1456
        }
      }, {
        "from" : {
          "x" : 6305,
          "y" : 1456
        },
        "to" : {
          "x" : 6143,
          "y" : 1519
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 3037,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6175,
          "y" : 1231
        },
        "to" : {
          "x" : 6052,
          "y" : 1264
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6169,
          "y" : 1237
        },
        "b" : {
          "x" : 6175,
          "y" : 1231
        },
        "c" : {
          "x" : 6167,
          "y" : 1229
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6167,
          "y" : 1229
        }
      }
    }, {
      "edgeId" : 2550,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6156,
          "y" : 1203
        },
        "to" : {
          "x" : 6072,
          "y" : 1195
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6149,
          "y" : 1206
        },
        "b" : {
          "x" : 6156,
          "y" : 1203
        },
        "c" : {
          "x" : 6149,
          "y" : 1198
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6149,
          "y" : 1198
        }
      }
    } ]
  }, {
    "id" : 2320,
    "reactomeId" : 109783,
    "displayName" : "p21 RAS:GTP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3522,
      "y" : 783
    },
    "minX" : 3371,
    "maxX" : 3569,
    "minY" : 749,
    "maxY" : 817,
    "prop" : {
      "x" : 3482,
      "y" : 763,
      "width" : 81,
      "height" : 41
    },
    "textPosition" : {
      "x" : 3490,
      "y" : 769
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3563,
          "y" : 763
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3563,
          "y" : 763
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13847,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3479,
          "y" : 768
        },
        "to" : {
          "x" : 3426,
          "y" : 749
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3471,
          "y" : 769
        },
        "b" : {
          "x" : 3479,
          "y" : 768
        },
        "c" : {
          "x" : 3474,
          "y" : 762
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3474,
          "y" : 762
        }
      }
    }, {
      "edgeId" : 8863,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3479,
          "y" : 792
        },
        "to" : {
          "x" : 3371,
          "y" : 817
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3473,
          "y" : 797
        },
        "b" : {
          "x" : 3479,
          "y" : 792
        },
        "c" : {
          "x" : 3471,
          "y" : 790
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3471,
          "y" : 790
        }
      }
    }, {
      "edgeId" : 8895,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3479,
          "y" : 782
        },
        "to" : {
          "x" : 3388,
          "y" : 781
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3472,
          "y" : 786
        },
        "b" : {
          "x" : 3479,
          "y" : 782
        },
        "c" : {
          "x" : 3472,
          "y" : 778
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3472,
          "y" : 778
        }
      }
    } ]
  }, {
    "id" : 2578,
    "reactomeId" : 1295625,
    "displayName" : "PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6232,
      "y" : 1423
    },
    "minX" : 6168,
    "maxX" : 6302,
    "minY" : 1392,
    "maxY" : 1448,
    "prop" : {
      "x" : 6168,
      "y" : 1398,
      "width" : 128,
      "height" : 50
    },
    "textPosition" : {
      "x" : 6169,
      "y" : 1399
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6296,
          "y" : 1398
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6296,
          "y" : 1398
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2514,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 3037,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2579,
    "reactomeId" : 934544,
    "displayName" : "PP2A (A:C)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6081,
      "y" : 1625
    },
    "minX" : 6025,
    "maxX" : 6144,
    "minY" : 1568,
    "maxY" : 1638,
    "prop" : {
      "x" : 6025,
      "y" : 1612,
      "width" : 113,
      "height" : 26
    },
    "textPosition" : {
      "x" : 6044,
      "y" : 1617
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6138,
          "y" : 1612
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6138,
          "y" : 1612
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2521,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6095,
          "y" : 1609
        },
        "to" : {
          "x" : 6144,
          "y" : 1568
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6098,
          "y" : 1601
        },
        "b" : {
          "x" : 6095,
          "y" : 1609
        },
        "c" : {
          "x" : 6103,
          "y" : 1608
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6103,
          "y" : 1608
        }
      }
    } ]
  }, {
    "id" : 2325,
    "reactomeId" : 29420,
    "displayName" : "GDP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3430,
      "y" : 866
    },
    "minX" : 3371,
    "maxX" : 3463,
    "minY" : 749,
    "maxY" : 881,
    "prop" : {
      "x" : 3398,
      "y" : 852,
      "width" : 64,
      "height" : 29
    },
    "textPosition" : {
      "x" : 3413,
      "y" : 856
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3457,
          "y" : 857
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3457,
          "y" : 857
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13847,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3429,
          "y" : 849
        },
        "to" : {
          "x" : 3426,
          "y" : 749
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3425,
          "y" : 842
        },
        "b" : {
          "x" : 3429,
          "y" : 849
        },
        "c" : {
          "x" : 3433,
          "y" : 842
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3433,
          "y" : 842
        }
      }
    }, {
      "edgeId" : 8863,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3412,
          "y" : 849
        },
        "to" : {
          "x" : 3371,
          "y" : 817
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3404,
          "y" : 848
        },
        "b" : {
          "x" : 3412,
          "y" : 849
        },
        "c" : {
          "x" : 3409,
          "y" : 842
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3409,
          "y" : 842
        }
      }
    }, {
      "edgeId" : 8895,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3422,
          "y" : 849
        },
        "to" : {
          "x" : 3388,
          "y" : 781
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3415,
          "y" : 845
        },
        "b" : {
          "x" : 3422,
          "y" : 849
        },
        "c" : {
          "x" : 3422,
          "y" : 841
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3422,
          "y" : 841
        }
      }
    } ]
  }, {
    "id" : 2326,
    "reactomeId" : 29438,
    "displayName" : "GTP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3178,
      "y" : 887
    },
    "minX" : 3146,
    "maxX" : 3295,
    "minY" : 749,
    "maxY" : 902,
    "prop" : {
      "x" : 3146,
      "y" : 873,
      "width" : 64,
      "height" : 29
    },
    "textPosition" : {
      "x" : 3162,
      "y" : 877
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3205,
          "y" : 878
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3205,
          "y" : 878
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13847,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3188,
          "y" : 870
        },
        "to" : {
          "x" : 3278,
          "y" : 749
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8863,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3201,
          "y" : 870
        },
        "to" : {
          "x" : 3295,
          "y" : 815
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8895,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3193,
          "y" : 870
        },
        "to" : {
          "x" : 3288,
          "y" : 781
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13593,
    "reactomeId" : 5654346,
    "displayName" : "FGFR1c:KAL1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 241,
      "y" : 1253
    },
    "minX" : 195,
    "maxX" : 359,
    "minY" : 1103,
    "maxY" : 1273,
    "prop" : {
      "x" : 195,
      "y" : 1233,
      "width" : 92,
      "height" : 40
    },
    "textPosition" : {
      "x" : 197,
      "y" : 1252
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 287,
          "y" : 1233
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 287,
          "y" : 1233
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13659,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 480,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 256,
          "y" : 1230
        },
        "to" : {
          "x" : 356,
          "y" : 1106
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 353,
          "y" : 1103
        },
        "b" : {
          "x" : 359,
          "y" : 1109
        },
        "c" : {
          "x" : 356,
          "y" : 1106
        },
        "type" : "STOP",
        "centre" : {
          "x" : 356,
          "y" : 1106
        }
      }
    } ]
  }, {
    "id" : 13594,
    "reactomeId" : 5654355,
    "displayName" : "KAL1:HS",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 117,
      "y" : 1108
    },
    "minX" : 78,
    "maxX" : 353,
    "minY" : 1083,
    "maxY" : 1128,
    "prop" : {
      "x" : 78,
      "y" : 1089,
      "width" : 78,
      "height" : 39
    },
    "textPosition" : {
      "x" : 88,
      "y" : 1107
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 156,
          "y" : 1089
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 156,
          "y" : 1089
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 480,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 159,
          "y" : 1106
        },
        "to" : {
          "x" : 353,
          "y" : 1099
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 346,
          "y" : 1103
        },
        "b" : {
          "x" : 353,
          "y" : 1099
        },
        "c" : {
          "x" : 346,
          "y" : 1095
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 346,
          "y" : 1095
        }
      }
    }, {
      "edgeId" : 13615,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2338,
    "reactomeId" : 1169480,
    "displayName" : "SHC1-2,SHC1-3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2326,
      "y" : 660
    },
    "minX" : 2290,
    "maxX" : 2363,
    "minY" : 478,
    "maxY" : 683,
    "prop" : {
      "x" : 2290,
      "y" : 638,
      "width" : 73,
      "height" : 45
    },
    "textPosition" : {
      "x" : 2298,
      "y" : 643
    },
    "connectors" : [ {
      "edgeId" : 8887,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2326,
          "y" : 632
        },
        "to" : {
          "x" : 2326,
          "y" : 478
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2594,
    "reactomeId" : 1295605,
    "displayName" : "PPA2A (A:C):S112/S115 p-SPRY2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 5868,
      "y" : 684
    },
    "minX" : 5791,
    "maxX" : 5951,
    "minY" : 659,
    "maxY" : 771,
    "prop" : {
      "x" : 5791,
      "y" : 665,
      "width" : 154,
      "height" : 38
    },
    "textPosition" : {
      "x" : 5789,
      "y" : 668
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5945,
          "y" : 665
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5945,
          "y" : 665
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2593,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2593,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 5854,
          "y" : 706
        },
        "to" : {
          "x" : 5828,
          "y" : 741
        }
      }, {
        "from" : {
          "x" : 5828,
          "y" : 741
        },
        "to" : {
          "x" : 5857,
          "y" : 765
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 5860,
          "y" : 767
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5860,
          "y" : 767
        }
      }
    } ]
  }, {
    "id" : 2595,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 5943,
      "y" : 832
    },
    "minX" : 5872,
    "maxX" : 5967,
    "minY" : 810,
    "maxY" : 844,
    "prop" : {
      "x" : 5921,
      "y" : 820,
      "width" : 45,
      "height" : 24
    },
    "textPosition" : {
      "x" : 5934,
      "y" : 821
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5961,
          "y" : 825
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5961,
          "y" : 825
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2593,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 5918,
          "y" : 825
        },
        "to" : {
          "x" : 5872,
          "y" : 810
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 5889,
            "y" : 811
          },
          "b" : {
            "x" : 5901,
            "y" : 823
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 5895,
            "y" : 817
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 5910,
          "y" : 827
        },
        "b" : {
          "x" : 5918,
          "y" : 825
        },
        "c" : {
          "x" : 5913,
          "y" : 819
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 5913,
          "y" : 819
        }
      }
    } ]
  }, {
    "id" : 1576,
    "reactomeId" : 109797,
    "displayName" : "GRB2-1:SOS1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3021,
      "y" : 621
    },
    "minX" : 2975,
    "maxX" : 3073,
    "minY" : 496,
    "maxY" : 706,
    "prop" : {
      "x" : 2975,
      "y" : 607,
      "width" : 92,
      "height" : 28
    },
    "textPosition" : {
      "x" : 2976,
      "y" : 614
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3067,
          "y" : 607
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3067,
          "y" : 607
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8858,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3024,
          "y" : 604
        },
        "to" : {
          "x" : 3051,
          "y" : 496
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8893,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3028,
          "y" : 638
        },
        "to" : {
          "x" : 3066,
          "y" : 706
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2602,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 6270,
      "y" : 910
    },
    "minX" : 6216,
    "maxX" : 6291,
    "minY" : 895,
    "maxY" : 960,
    "prop" : {
      "x" : 6251,
      "y" : 896,
      "width" : 39,
      "height" : 29
    },
    "textPosition" : {
      "x" : 6255,
      "y" : 900
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6285,
          "y" : 901
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6285,
          "y" : 901
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2601,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6254,
          "y" : 928
        },
        "to" : {
          "x" : 6216,
          "y" : 960
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 6229,
            "y" : 938
          },
          "b" : {
            "x" : 6241,
            "y" : 950
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 6235,
            "y" : 944
          }
        }
      }
    } ]
  }, {
    "id" : 2603,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 6284,
      "y" : 1045
    },
    "minX" : 6219,
    "maxX" : 6305,
    "minY" : 1030,
    "maxY" : 1060,
    "prop" : {
      "x" : 6264,
      "y" : 1031,
      "width" : 40,
      "height" : 29
    },
    "textPosition" : {
      "x" : 6267,
      "y" : 1035
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6299,
          "y" : 1036
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6299,
          "y" : 1036
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2601,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6261,
          "y" : 1041
        },
        "to" : {
          "x" : 6219,
          "y" : 1035
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 6234,
            "y" : 1032
          },
          "b" : {
            "x" : 6246,
            "y" : 1044
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 6240,
            "y" : 1038
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 6254,
          "y" : 1044
        },
        "b" : {
          "x" : 6261,
          "y" : 1041
        },
        "c" : {
          "x" : 6255,
          "y" : 1036
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6255,
          "y" : 1036
        }
      }
    } ]
  }, {
    "id" : 2604,
    "reactomeId" : 934578,
    "displayName" : "PP2A(A:C):S112/S121-pSPRY2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6227,
      "y" : 1131
    },
    "minX" : 5922,
    "maxX" : 6292,
    "minY" : 1035,
    "maxY" : 1156,
    "prop" : {
      "x" : 6169,
      "y" : 1107,
      "width" : 117,
      "height" : 49
    },
    "textPosition" : {
      "x" : 6187,
      "y" : 1107
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6286,
          "y" : 1107
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6286,
          "y" : 1107
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2601,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6224,
          "y" : 1104
        },
        "to" : {
          "x" : 6219,
          "y" : 1035
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6220,
          "y" : 1097
        },
        "b" : {
          "x" : 6224,
          "y" : 1104
        },
        "c" : {
          "x" : 6227,
          "y" : 1097
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6227,
          "y" : 1097
        }
      }
    }, {
      "edgeId" : 2550,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 6166,
          "y" : 1132
        },
        "to" : {
          "x" : 5922,
          "y" : 1141
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 5922,
          "y" : 1137
        },
        "b" : {
          "x" : 5922,
          "y" : 1145
        },
        "c" : {
          "x" : 5922,
          "y" : 1141
        },
        "type" : "STOP",
        "centre" : {
          "x" : 5922,
          "y" : 1141
        }
      }
    } ]
  }, {
    "id" : 2605,
    "reactomeId" : 947860,
    "displayName" : "p-T250,T255,T385,S437-MKNK1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 5994,
      "y" : 993
    },
    "minX" : 5943,
    "maxX" : 6205,
    "minY" : 956,
    "maxY" : 1024,
    "prop" : {
      "x" : 5943,
      "y" : 962,
      "width" : 103,
      "height" : 62
    },
    "innerProp" : {
      "x" : 5943,
      "y" : 968,
      "width" : 103,
      "height" : 56
    },
    "textPosition" : {
      "x" : 5949,
      "y" : 968
    },
    "nodeAttachments" : [ {
      "reactomeId" : 947828,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 250",
      "shape" : {
        "a" : {
          "x" : 5953,
          "y" : 956
        },
        "b" : {
          "x" : 5965,
          "y" : 968
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 5959,
          "y" : 962
        }
      }
    }, {
      "reactomeId" : 947839,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 255",
      "shape" : {
        "a" : {
          "x" : 5969,
          "y" : 956
        },
        "b" : {
          "x" : 5981,
          "y" : 968
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 5975,
          "y" : 962
        }
      }
    }, {
      "reactomeId" : 947849,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 385",
      "shape" : {
        "a" : {
          "x" : 5985,
          "y" : 956
        },
        "b" : {
          "x" : 5997,
          "y" : 968
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 5991,
          "y" : 962
        }
      }
    }, {
      "reactomeId" : 947827,
      "label" : "P",
      "description" : "O-phospho-L-serine at 437",
      "shape" : {
        "a" : {
          "x" : 6001,
          "y" : 956
        },
        "b" : {
          "x" : 6013,
          "y" : 968
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 6007,
          "y" : 962
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6046,
          "y" : 962
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6046,
          "y" : 962
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2601,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 6049,
          "y" : 993
        },
        "to" : {
          "x" : 6197,
          "y" : 996
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 6201,
          "y" : 996
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6201,
          "y" : 996
        }
      }
    } ]
  }, {
    "id" : 13614,
    "reactomeId" : 5654345,
    "displayName" : "KAL1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 34,
      "y" : 865
    },
    "minX" : 0,
    "maxX" : 75,
    "minY" : 846,
    "maxY" : 998,
    "prop" : {
      "x" : 0,
      "y" : 852,
      "width" : 69,
      "height" : 26
    },
    "textPosition" : {
      "x" : 16,
      "y" : 854
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 69,
          "y" : 852
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 69,
          "y" : 852
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13659,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 30,
          "y" : 881
        },
        "to" : {
          "x" : 17,
          "y" : 928
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 13615,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 36,
          "y" : 881
        },
        "to" : {
          "x" : 63,
          "y" : 998
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13616,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3623,
      "y" : 470
    },
    "minX" : 3603,
    "maxX" : 3644,
    "minY" : 395,
    "maxY" : 485,
    "prop" : {
      "x" : 3603,
      "y" : 455,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3607,
      "y" : 459
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3638,
          "y" : 460
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3638,
          "y" : 460
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8866,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3625,
          "y" : 452
        },
        "to" : {
          "x" : 3637,
          "y" : 395
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3625,
            "y" : 417
          },
          "b" : {
            "x" : 3637,
            "y" : 429
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3631,
            "y" : 423
          }
        }
      }
    } ]
  }, {
    "id" : 13618,
    "reactomeId" : 5656056,
    "displayName" : "FLRT1,2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2096,
      "y" : 591
    },
    "minX" : 2053,
    "maxX" : 2161,
    "minY" : 543,
    "maxY" : 609,
    "prop" : {
      "x" : 2053,
      "y" : 574,
      "width" : 86,
      "height" : 35
    },
    "textPosition" : {
      "x" : 2062,
      "y" : 581
    },
    "connectors" : [ {
      "edgeId" : 13669,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2119,
          "y" : 568
        },
        "to" : {
          "x" : 2161,
          "y" : 543
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13874,
    "reactomeId" : 9839332,
    "displayName" : "FGF2:TGFBR3:GIPC1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 803,
      "y" : 476
    },
    "minX" : 368,
    "maxX" : 873,
    "minY" : 459,
    "maxY" : 1092,
    "prop" : {
      "x" : 740,
      "y" : 465,
      "width" : 127,
      "height" : 23
    },
    "textPosition" : {
      "x" : 756,
      "y" : 453
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 867,
          "y" : 465
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 867,
          "y" : 465
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 467,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 773,
          "y" : 491
        },
        "to" : {
          "x" : 488,
          "y" : 597
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 493,
          "y" : 591
        },
        "b" : {
          "x" : 488,
          "y" : 597
        },
        "c" : {
          "x" : 496,
          "y" : 598
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 496,
          "y" : 598
        }
      }
    }, {
      "edgeId" : 480,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 802,
          "y" : 491
        },
        "to" : {
          "x" : 799,
          "y" : 888
        }
      }, {
        "from" : {
          "x" : 799,
          "y" : 888
        },
        "to" : {
          "x" : 485,
          "y" : 960
        }
      }, {
        "from" : {
          "x" : 485,
          "y" : 960
        },
        "to" : {
          "x" : 368,
          "y" : 1092
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 370,
          "y" : 1084
        },
        "b" : {
          "x" : 368,
          "y" : 1092
        },
        "c" : {
          "x" : 376,
          "y" : 1089
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 376,
          "y" : 1089
        }
      }
    } ]
  }, {
    "id" : 2615,
    "reactomeId" : 1295598,
    "displayName" : "SPRY2:B-RAF",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3478,
      "y" : 1128
    },
    "minX" : 3430,
    "maxX" : 3533,
    "minY" : 1109,
    "maxY" : 1142,
    "prop" : {
      "x" : 3430,
      "y" : 1115,
      "width" : 97,
      "height" : 27
    },
    "textPosition" : {
      "x" : 3435,
      "y" : 1121
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3527,
          "y" : 1115
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3527,
          "y" : 1115
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2651,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13624,
    "reactomeId" : 5656063,
    "displayName" : "Activated FGFR1:FLRT",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2256,
      "y" : 582
    },
    "minX" : 2203,
    "maxX" : 2316,
    "minY" : 558,
    "maxY" : 600,
    "prop" : {
      "x" : 2203,
      "y" : 564,
      "width" : 107,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2217,
      "y" : 565
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2310,
          "y" : 564
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2310,
          "y" : 564
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13669,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 824,
    "reactomeId" : 500333,
    "displayName" : "Activated FGFR1c bound to FGF23:Klotho",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 377,
      "y" : 1822
    },
    "minX" : 323,
    "maxX" : 438,
    "minY" : 1774,
    "maxY" : 1849,
    "prop" : {
      "x" : 323,
      "y" : 1796,
      "width" : 109,
      "height" : 53
    },
    "textPosition" : {
      "x" : 324,
      "y" : 1800
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 432,
          "y" : 1796
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 432,
          "y" : 1796
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 822,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 373,
          "y" : 1793
        },
        "to" : {
          "x" : 370,
          "y" : 1774
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 368,
          "y" : 1787
        },
        "b" : {
          "x" : 373,
          "y" : 1793
        },
        "c" : {
          "x" : 376,
          "y" : 1786
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 376,
          "y" : 1786
        }
      }
    } ]
  }, {
    "id" : 2616,
    "reactomeId" : 1295587,
    "displayName" : "S110/S120 p-SPRY2:B-RAF",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3678,
      "y" : 1128
    },
    "minX" : 3630,
    "maxX" : 3732,
    "minY" : 1104,
    "maxY" : 1146,
    "prop" : {
      "x" : 3630,
      "y" : 1110,
      "width" : 96,
      "height" : 36
    },
    "textPosition" : {
      "x" : 3632,
      "y" : 1111
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3726,
          "y" : 1110
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3726,
          "y" : 1110
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2651,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2620,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13114,
    "reactomeId" : 5654215,
    "displayName" : "SPRED1/2 dimer",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1334,
      "y" : 2039
    },
    "minX" : 791,
    "maxX" : 1396,
    "minY" : 1969,
    "maxY" : 2063,
    "prop" : {
      "x" : 1273,
      "y" : 2016,
      "width" : 123,
      "height" : 47
    },
    "textPosition" : {
      "x" : 1280,
      "y" : 2029
    },
    "connectors" : [ {
      "edgeId" : 13113,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1267,
          "y" : 2031
        },
        "to" : {
          "x" : 791,
          "y" : 1969
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13115,
    "reactomeId" : 5654350,
    "displayName" : "FGFRL1 dimer:SPRED1/2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1018,
      "y" : 2089
    },
    "minX" : 963,
    "maxX" : 1079,
    "minY" : 2062,
    "maxY" : 2111,
    "prop" : {
      "x" : 963,
      "y" : 2068,
      "width" : 110,
      "height" : 43
    },
    "textPosition" : {
      "x" : 964,
      "y" : 2076
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1073,
          "y" : 2068
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1073,
          "y" : 2068
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13113,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2621,
    "reactomeId" : 1295590,
    "displayName" : "p-S110,S120-SPRY2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3840,
      "y" : 1176
    },
    "minX" : 3765,
    "maxX" : 3921,
    "minY" : 1123,
    "maxY" : 1190,
    "prop" : {
      "x" : 3765,
      "y" : 1162,
      "width" : 150,
      "height" : 28
    },
    "innerProp" : {
      "x" : 3765,
      "y" : 1168,
      "width" : 150,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3774,
      "y" : 1165
    },
    "nodeAttachments" : [ {
      "reactomeId" : 1295633,
      "label" : "P",
      "description" : "O-phospho-L-serine at 110",
      "shape" : {
        "a" : {
          "x" : 3775,
          "y" : 1156
        },
        "b" : {
          "x" : 3787,
          "y" : 1168
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 3781,
          "y" : 1162
        }
      }
    }, {
      "reactomeId" : 1295630,
      "label" : "P",
      "description" : "O-phospho-L-serine at 120",
      "shape" : {
        "a" : {
          "x" : 3791,
          "y" : 1156
        },
        "b" : {
          "x" : 3803,
          "y" : 1168
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 3797,
          "y" : 1162
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3915,
          "y" : 1162
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3915,
          "y" : 1162
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2620,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3826,
          "y" : 1159
        },
        "to" : {
          "x" : 3788,
          "y" : 1123
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3818,
          "y" : 1157
        },
        "b" : {
          "x" : 3826,
          "y" : 1159
        },
        "c" : {
          "x" : 3824,
          "y" : 1151
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3824,
          "y" : 1151
        }
      }
    } ]
  }, {
    "id" : 2622,
    "reactomeId" : 167224,
    "displayName" : "BRAF",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3859,
      "y" : 1123
    },
    "minX" : 3788,
    "maxX" : 3887,
    "minY" : 1106,
    "maxY" : 1134,
    "prop" : {
      "x" : 3837,
      "y" : 1112,
      "width" : 44,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3839,
      "y" : 1112
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3881,
          "y" : 1112
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3881,
          "y" : 1112
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2620,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3834,
          "y" : 1123
        },
        "to" : {
          "x" : 3788,
          "y" : 1123
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3827,
          "y" : 1127
        },
        "b" : {
          "x" : 3834,
          "y" : 1123
        },
        "c" : {
          "x" : 3827,
          "y" : 1119
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3827,
          "y" : 1119
        }
      }
    } ]
  }, {
    "id" : 2125,
    "reactomeId" : 170963,
    "displayName" : "FRS2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2312,
      "y" : 399
    },
    "minX" : 2267,
    "maxX" : 2363,
    "minY" : 341,
    "maxY" : 411,
    "prop" : {
      "x" : 2267,
      "y" : 387,
      "width" : 90,
      "height" : 24
    },
    "textPosition" : {
      "x" : 2292,
      "y" : 388
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2357,
          "y" : 387
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2357,
          "y" : 387
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8832,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2309,
          "y" : 384
        },
        "to" : {
          "x" : 2302,
          "y" : 341
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2127,
    "reactomeId" : 191482,
    "displayName" : "FRS3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2279,
      "y" : 222
    },
    "minX" : 2235,
    "maxX" : 2332,
    "minY" : 203,
    "maxY" : 258,
    "prop" : {
      "x" : 2235,
      "y" : 209,
      "width" : 88,
      "height" : 27
    },
    "textPosition" : {
      "x" : 2259,
      "y" : 212
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2323,
          "y" : 209
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2323,
          "y" : 209
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8839,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2298,
          "y" : 239
        },
        "to" : {
          "x" : 2332,
          "y" : 258
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1106,
    "reactomeId" : 162563,
    "displayName" : "PTPN11",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3430,
      "y" : 628
    },
    "minX" : 3393,
    "maxX" : 6054,
    "minY" : 389,
    "maxY" : 1375,
    "prop" : {
      "x" : 3393,
      "y" : 615,
      "width" : 75,
      "height" : 27
    },
    "textPosition" : {
      "x" : 3402,
      "y" : 618
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3468,
          "y" : 615
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3468,
          "y" : 615
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 3037,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3464,
          "y" : 645
        },
        "to" : {
          "x" : 5359,
          "y" : 1375
        }
      }, {
        "from" : {
          "x" : 5359,
          "y" : 1375
        },
        "to" : {
          "x" : 6046,
          "y" : 1360
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 6050,
          "y" : 1360
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6050,
          "y" : 1360
        }
      }
    }, {
      "edgeId" : 8864,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3428,
          "y" : 612
        },
        "to" : {
          "x" : 3402,
          "y" : 389
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 13655,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 573,
      "y" : 712
    },
    "minX" : 487,
    "maxX" : 594,
    "minY" : 696,
    "maxY" : 727,
    "prop" : {
      "x" : 553,
      "y" : 697,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 557,
      "y" : 701
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 588,
          "y" : 702
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 588,
          "y" : 702
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 474,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 550,
          "y" : 715
        },
        "to" : {
          "x" : 487,
          "y" : 727
        }
      } ],
      "stoichiometry" : {
        "value" : 16,
        "shape" : {
          "a" : {
            "x" : 512,
            "y" : 715
          },
          "b" : {
            "x" : 524,
            "y" : 727
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 518,
            "y" : 721
          }
        }
      }
    } ]
  }, {
    "id" : 13656,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 561,
      "y" : 792
    },
    "minX" : 483,
    "maxX" : 583,
    "minY" : 775,
    "maxY" : 807,
    "prop" : {
      "x" : 540,
      "y" : 777,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 544,
      "y" : 781
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 577,
          "y" : 782
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 577,
          "y" : 782
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 474,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 537,
          "y" : 787
        },
        "to" : {
          "x" : 483,
          "y" : 775
        }
      } ],
      "stoichiometry" : {
        "value" : 16,
        "shape" : {
          "a" : {
            "x" : 504,
            "y" : 775
          },
          "b" : {
            "x" : 516,
            "y" : 787
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 510,
            "y" : 781
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 529,
          "y" : 789
        },
        "b" : {
          "x" : 537,
          "y" : 787
        },
        "c" : {
          "x" : 531,
          "y" : 782
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 531,
          "y" : 782
        }
      }
    } ]
  }, {
    "id" : 2395,
    "reactomeId" : 113595,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 5357,
      "y" : 631
    },
    "minX" : 5328,
    "maxX" : 5386,
    "minY" : 509,
    "maxY" : 642,
    "prop" : {
      "x" : 5328,
      "y" : 621,
      "width" : 58,
      "height" : 21
    },
    "textPosition" : {
      "x" : 5344,
      "y" : 621
    },
    "connectors" : [ {
      "edgeId" : 8944,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 5359,
          "y" : 615
        },
        "to" : {
          "x" : 5381,
          "y" : 509
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2656,
    "reactomeId" : 1268261,
    "displayName" : "p-T,Y MAPK dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3484,
      "y" : 1070
    },
    "minX" : 2757,
    "maxX" : 3595,
    "minY" : 551,
    "maxY" : 1121,
    "prop" : {
      "x" : 3421,
      "y" : 1056,
      "width" : 127,
      "height" : 28
    },
    "textPosition" : {
      "x" : 3424,
      "y" : 1059
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 2651,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 3554,
          "y" : 1078
        },
        "to" : {
          "x" : 3577,
          "y" : 1082
        }
      }, {
        "from" : {
          "x" : 3577,
          "y" : 1082
        },
        "to" : {
          "x" : 3594,
          "y" : 1121
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3588,
          "y" : 1116
        },
        "b" : {
          "x" : 3594,
          "y" : 1121
        },
        "c" : {
          "x" : 3595,
          "y" : 1113
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 3595,
          "y" : 1113
        }
      }
    }, {
      "edgeId" : 8929,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3415,
          "y" : 1069
        },
        "to" : {
          "x" : 2757,
          "y" : 1066
        }
      }, {
        "from" : {
          "x" : 2757,
          "y" : 1066
        },
        "to" : {
          "x" : 2762,
          "y" : 559
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2762,
          "y" : 555
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2762,
          "y" : 555
        }
      }
    } ]
  }, {
    "id" : 2401,
    "reactomeId" : 189878,
    "displayName" : "FGFR1b",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 456,
      "y" : 410
    },
    "minX" : 398,
    "maxX" : 521,
    "minY" : 385,
    "maxY" : 581,
    "prop" : {
      "x" : 398,
      "y" : 391,
      "width" : 117,
      "height" : 38
    },
    "textPosition" : {
      "x" : 429,
      "y" : 399
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 515,
          "y" : 391
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 515,
          "y" : 391
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 467,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 458,
          "y" : 432
        },
        "to" : {
          "x" : 480,
          "y" : 581
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 463,
            "y" : 500
          },
          "b" : {
            "x" : 475,
            "y" : 512
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 469,
            "y" : 506
          }
        }
      }
    } ]
  }, {
    "id" : 2402,
    "reactomeId" : 189897,
    "displayName" : "FGFR1c",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 334,
      "y" : 879
    },
    "minX" : 17,
    "maxX" : 509,
    "minY" : 854,
    "maxY" : 1587,
    "prop" : {
      "x" : 273,
      "y" : 860,
      "width" : 122,
      "height" : 39
    },
    "textPosition" : {
      "x" : 307,
      "y" : 869
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 395,
          "y" : 860
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 395,
          "y" : 860
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13659,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 270,
          "y" : 888
        },
        "to" : {
          "x" : 17,
          "y" : 928
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 480,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 336,
          "y" : 902
        },
        "to" : {
          "x" : 360,
          "y" : 1067
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 342,
            "y" : 978
          },
          "b" : {
            "x" : 354,
            "y" : 990
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 348,
            "y" : 984
          }
        }
      }
    }, {
      "edgeId" : 494,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 343,
          "y" : 902
        },
        "to" : {
          "x" : 505,
          "y" : 1246
        }
      }, {
        "from" : {
          "x" : 505,
          "y" : 1246
        },
        "to" : {
          "x" : 509,
          "y" : 1502
        }
      }, {
        "from" : {
          "x" : 509,
          "y" : 1502
        },
        "to" : {
          "x" : 359,
          "y" : 1587
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 418,
            "y" : 1068
          },
          "b" : {
            "x" : 430,
            "y" : 1080
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 424,
            "y" : 1074
          }
        }
      }
    } ]
  }, {
    "id" : 13670,
    "reactomeId" : 5673001,
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 3480,
      "y" : 935
    },
    "minX" : 3411,
    "maxX" : 3550,
    "minY" : 900,
    "maxY" : 970,
    "prop" : {
      "x" : 3411,
      "y" : 900,
      "width" : 139,
      "height" : 70
    },
    "textPosition" : {
      "x" : 3421,
      "y" : 913
    },
    "connectors" : [ ]
  }, {
    "id" : 2668,
    "reactomeId" : 1257604,
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 4899,
      "y" : 424
    },
    "minX" : 4830,
    "maxX" : 4968,
    "minY" : 394,
    "maxY" : 455,
    "prop" : {
      "x" : 4830,
      "y" : 394,
      "width" : 138,
      "height" : 61
    },
    "textPosition" : {
      "x" : 4832,
      "y" : 403
    },
    "connectors" : [ ]
  }, {
    "id" : 8833,
    "reactomeId" : 5654170,
    "displayName" : "Activated FGFR1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2175,
      "y" : 414
    },
    "minX" : 1576,
    "maxX" : 2332,
    "minY" : 141,
    "maxY" : 543,
    "prop" : {
      "x" : 2120,
      "y" : 403,
      "width" : 110,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2120,
      "y" : 403
    },
    "connectors" : [ {
      "edgeId" : 8832,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2194,
          "y" : 397
        },
        "to" : {
          "x" : 2302,
          "y" : 341
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8839,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2186,
          "y" : 397
        },
        "to" : {
          "x" : 2332,
          "y" : 258
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 13669,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2173,
          "y" : 431
        },
        "to" : {
          "x" : 2161,
          "y" : 543
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8880,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2154,
          "y" : 397
        },
        "to" : {
          "x" : 2043,
          "y" : 343
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8886,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2175,
          "y" : 397
        },
        "to" : {
          "x" : 2181,
          "y" : 149
        }
      }, {
        "from" : {
          "x" : 2181,
          "y" : 149
        },
        "to" : {
          "x" : 1576,
          "y" : 141
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2171,
          "y" : 390
        },
        "b" : {
          "x" : 2175,
          "y" : 397
        },
        "c" : {
          "x" : 2179,
          "y" : 390
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2179,
          "y" : 390
        }
      }
    }, {
      "edgeId" : 8887,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2200,
          "y" : 431
        },
        "to" : {
          "x" : 2326,
          "y" : 478
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 8838,
    "reactomeId" : 5654176,
    "displayName" : "Activated FGFR1:FRS2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2465,
      "y" : 347
    },
    "minX" : 2412,
    "maxX" : 2719,
    "minY" : 323,
    "maxY" : 543,
    "prop" : {
      "x" : 2412,
      "y" : 329,
      "width" : 107,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2424,
      "y" : 330
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2519,
          "y" : 329
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2519,
          "y" : 329
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8832,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8850,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2522,
          "y" : 351
        },
        "to" : {
          "x" : 2578,
          "y" : 356
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8850,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2498,
          "y" : 368
        },
        "to" : {
          "x" : 2547,
          "y" : 391
        }
      }, {
        "from" : {
          "x" : 2547,
          "y" : 391
        },
        "to" : {
          "x" : 2591,
          "y" : 363
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2594,
          "y" : 361
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2594,
          "y" : 361
        }
      }
    }, {
      "edgeId" : 8929,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2488,
          "y" : 368
        },
        "to" : {
          "x" : 2719,
          "y" : 543
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 8840,
    "reactomeId" : 5654255,
    "displayName" : "Activated FGFR1:FRS3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2463,
      "y" : 258
    },
    "minX" : 2409,
    "maxX" : 2604,
    "minY" : 165,
    "maxY" : 285,
    "prop" : {
      "x" : 2409,
      "y" : 232,
      "width" : 109,
      "height" : 53
    },
    "textPosition" : {
      "x" : 2422,
      "y" : 250
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2518,
          "y" : 232
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2518,
          "y" : 232
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8839,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8854,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2521,
          "y" : 255
        },
        "to" : {
          "x" : 2584,
          "y" : 253
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8854,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2479,
          "y" : 229
        },
        "to" : {
          "x" : 2521,
          "y" : 165
        }
      }, {
        "from" : {
          "x" : 2521,
          "y" : 165
        },
        "to" : {
          "x" : 2597,
          "y" : 242
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2600,
          "y" : 244
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2600,
          "y" : 244
        }
      }
    } ]
  }, {
    "id" : 2449,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 436,
      "y" : 1319
    },
    "minX" : 358,
    "maxX" : 467,
    "minY" : 1305,
    "maxY" : 1332,
    "prop" : {
      "x" : 406,
      "y" : 1306,
      "width" : 60,
      "height" : 26
    },
    "textPosition" : {
      "x" : 420,
      "y" : 1308
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 461,
          "y" : 1311
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 461,
          "y" : 1311
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 487,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 403,
          "y" : 1320
        },
        "to" : {
          "x" : 358,
          "y" : 1323
        }
      } ],
      "stoichiometry" : {
        "value" : 16,
        "shape" : {
          "a" : {
            "x" : 374,
            "y" : 1315
          },
          "b" : {
            "x" : 386,
            "y" : 1327
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 380,
            "y" : 1321
          }
        }
      }
    } ]
  }, {
    "id" : 2450,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 421,
      "y" : 1359
    },
    "minX" : 358,
    "maxX" : 449,
    "minY" : 1346,
    "maxY" : 1371,
    "prop" : {
      "x" : 394,
      "y" : 1347,
      "width" : 54,
      "height" : 24
    },
    "textPosition" : {
      "x" : 404,
      "y" : 1348
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 443,
          "y" : 1352
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 443,
          "y" : 1352
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 487,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 391,
          "y" : 1357
        },
        "to" : {
          "x" : 358,
          "y" : 1355
        }
      } ],
      "stoichiometry" : {
        "value" : 16,
        "shape" : {
          "a" : {
            "x" : 368,
            "y" : 1350
          },
          "b" : {
            "x" : 380,
            "y" : 1362
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 374,
            "y" : 1356
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 384,
          "y" : 1361
        },
        "b" : {
          "x" : 391,
          "y" : 1357
        },
        "c" : {
          "x" : 384,
          "y" : 1353
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 384,
          "y" : 1353
        }
      }
    } ]
  }, {
    "id" : 8851,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2559,
      "y" : 317
    },
    "minX" : 2524,
    "maxX" : 2595,
    "minY" : 253,
    "maxY" : 356,
    "prop" : {
      "x" : 2524,
      "y" : 303,
      "width" : 70,
      "height" : 29
    },
    "textPosition" : {
      "x" : 2543,
      "y" : 307
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2589,
          "y" : 308
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2589,
          "y" : 308
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8850,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2566,
          "y" : 335
        },
        "to" : {
          "x" : 2578,
          "y" : 356
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 2566,
            "y" : 339
          },
          "b" : {
            "x" : 2578,
            "y" : 351
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2572,
            "y" : 345
          }
        }
      }
    }, {
      "edgeId" : 8854,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2564,
          "y" : 300
        },
        "to" : {
          "x" : 2584,
          "y" : 253
        }
      } ],
      "stoichiometry" : {
        "value" : 5,
        "shape" : {
          "a" : {
            "x" : 2568,
            "y" : 270
          },
          "b" : {
            "x" : 2580,
            "y" : 282
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2574,
            "y" : 276
          }
        }
      }
    } ]
  }, {
    "id" : 2452,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 439,
      "y" : 1738
    },
    "minX" : 367,
    "maxX" : 468,
    "minY" : 1725,
    "maxY" : 1751,
    "prop" : {
      "x" : 411,
      "y" : 1726,
      "width" : 56,
      "height" : 25
    },
    "textPosition" : {
      "x" : 423,
      "y" : 1728
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 462,
          "y" : 1731
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 462,
          "y" : 1731
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 822,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 408,
          "y" : 1737
        },
        "to" : {
          "x" : 367,
          "y" : 1736
        }
      } ],
      "stoichiometry" : {
        "value" : 16,
        "shape" : {
          "a" : {
            "x" : 381,
            "y" : 1730
          },
          "b" : {
            "x" : 393,
            "y" : 1742
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 387,
            "y" : 1736
          }
        }
      }
    } ]
  }, {
    "id" : 8852,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2669,
      "y" : 320
    },
    "minX" : 2633,
    "maxX" : 2706,
    "minY" : 252,
    "maxY" : 355,
    "prop" : {
      "x" : 2633,
      "y" : 305,
      "width" : 72,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2652,
      "y" : 309
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2700,
          "y" : 310
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2700,
          "y" : 310
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8850,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2654,
          "y" : 338
        },
        "to" : {
          "x" : 2634,
          "y" : 355
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 2638,
            "y" : 340
          },
          "b" : {
            "x" : 2650,
            "y" : 352
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2644,
            "y" : 346
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2651,
          "y" : 346
        },
        "b" : {
          "x" : 2654,
          "y" : 338
        },
        "c" : {
          "x" : 2646,
          "y" : 339
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2646,
          "y" : 339
        }
      }
    }, {
      "edgeId" : 8854,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2661,
          "y" : 302
        },
        "to" : {
          "x" : 2635,
          "y" : 252
        }
      } ],
      "stoichiometry" : {
        "value" : 5,
        "shape" : {
          "a" : {
            "x" : 2642,
            "y" : 271
          },
          "b" : {
            "x" : 2654,
            "y" : 283
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2648,
            "y" : 277
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2654,
          "y" : 298
        },
        "b" : {
          "x" : 2661,
          "y" : 302
        },
        "c" : {
          "x" : 2661,
          "y" : 294
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2661,
          "y" : 294
        }
      }
    } ]
  }, {
    "id" : 2453,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 440,
      "y" : 1779
    },
    "minX" : 370,
    "maxX" : 467,
    "minY" : 1766,
    "maxY" : 1791,
    "prop" : {
      "x" : 414,
      "y" : 1767,
      "width" : 52,
      "height" : 24
    },
    "textPosition" : {
      "x" : 423,
      "y" : 1768
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 461,
          "y" : 1772
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 461,
          "y" : 1772
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 822,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 411,
          "y" : 1777
        },
        "to" : {
          "x" : 370,
          "y" : 1774
        }
      } ],
      "stoichiometry" : {
        "value" : 16,
        "shape" : {
          "a" : {
            "x" : 384,
            "y" : 1769
          },
          "b" : {
            "x" : 396,
            "y" : 1781
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 390,
            "y" : 1775
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 404,
          "y" : 1780
        },
        "b" : {
          "x" : 411,
          "y" : 1777
        },
        "c" : {
          "x" : 404,
          "y" : 1773
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 404,
          "y" : 1773
        }
      }
    } ]
  }, {
    "id" : 8853,
    "reactomeId" : 5654200,
    "displayName" : "Activated FGFR1:p-FRS2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2779,
      "y" : 367
    },
    "minX" : 2634,
    "maxX" : 4022,
    "minY" : 317,
    "maxY" : 393,
    "prop" : {
      "x" : 2720,
      "y" : 342,
      "width" : 119,
      "height" : 51
    },
    "textPosition" : {
      "x" : 2723,
      "y" : 358
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2839,
          "y" : 342
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2839,
          "y" : 342
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8896,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2842,
          "y" : 351
        },
        "to" : {
          "x" : 2966,
          "y" : 317
        }
      }, {
        "from" : {
          "x" : 2966,
          "y" : 317
        },
        "to" : {
          "x" : 4022,
          "y" : 321
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8850,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2717,
          "y" : 362
        },
        "to" : {
          "x" : 2634,
          "y" : 355
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2710,
          "y" : 365
        },
        "b" : {
          "x" : 2717,
          "y" : 362
        },
        "c" : {
          "x" : 2710,
          "y" : 357
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2710,
          "y" : 357
        }
      }
    } ]
  }, {
    "id" : 2199,
    "reactomeId" : 179849,
    "displayName" : "GRB2:GAB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3998,
      "y" : 748
    },
    "minX" : 3959,
    "maxX" : 4054,
    "minY" : 717,
    "maxY" : 759,
    "prop" : {
      "x" : 3959,
      "y" : 737,
      "width" : 79,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3959,
      "y" : 738
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4038,
          "y" : 737
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4038,
          "y" : 737
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2276,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4017,
          "y" : 734
        },
        "to" : {
          "x" : 4054,
          "y" : 717
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 8856,
    "reactomeId" : 5654261,
    "displayName" : "Activated FGFR1:p-FRS3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2785,
      "y" : 254
    },
    "minX" : 2635,
    "maxX" : 2849,
    "minY" : 223,
    "maxY" : 279,
    "prop" : {
      "x" : 2728,
      "y" : 229,
      "width" : 115,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2729,
      "y" : 244
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2843,
          "y" : 229
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2843,
          "y" : 229
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8854,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2725,
          "y" : 253
        },
        "to" : {
          "x" : 2635,
          "y" : 252
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2718,
          "y" : 257
        },
        "b" : {
          "x" : 2725,
          "y" : 253
        },
        "c" : {
          "x" : 2718,
          "y" : 249
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2718,
          "y" : 249
        }
      }
    } ]
  }, {
    "id" : 4504,
    "reactomeId" : 190915,
    "displayName" : "HS",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 132,
      "y" : 587
    },
    "minX" : 82,
    "maxX" : 480,
    "minY" : 568,
    "maxY" : 648,
    "prop" : {
      "x" : 82,
      "y" : 569,
      "width" : 101,
      "height" : 36
    },
    "textPosition" : {
      "x" : 120,
      "y" : 576
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 178,
          "y" : 574
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 178,
          "y" : 574
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 467,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 186,
          "y" : 586
        },
        "to" : {
          "x" : 480,
          "y" : 581
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 467,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 186,
          "y" : 598
        },
        "to" : {
          "x" : 391,
          "y" : 648
        }
      }, {
        "from" : {
          "x" : 391,
          "y" : 648
        },
        "to" : {
          "x" : 472,
          "y" : 604
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 468,
          "y" : 611
        },
        "b" : {
          "x" : 472,
          "y" : 604
        },
        "c" : {
          "x" : 464,
          "y" : 604
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 464,
          "y" : 604
        }
      }
    } ]
  }, {
    "id" : 4505,
    "reactomeId" : 190915,
    "displayName" : "HS",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 166,
      "y" : 1620
    },
    "minX" : 115,
    "maxX" : 359,
    "minY" : 1587,
    "maxY" : 1636,
    "prop" : {
      "x" : 115,
      "y" : 1604,
      "width" : 102,
      "height" : 32
    },
    "textPosition" : {
      "x" : 153,
      "y" : 1609
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 212,
          "y" : 1609
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 212,
          "y" : 1609
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 494,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 220,
          "y" : 1611
        },
        "to" : {
          "x" : 359,
          "y" : 1587
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 494,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 220,
          "y" : 1622
        },
        "to" : {
          "x" : 354,
          "y" : 1629
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 347,
          "y" : 1633
        },
        "b" : {
          "x" : 354,
          "y" : 1629
        },
        "c" : {
          "x" : 347,
          "y" : 1625
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 347,
          "y" : 1625
        }
      }
    } ]
  }, {
    "id" : 8859,
    "reactomeId" : 5654262,
    "displayName" : "Activated FGFR1:p-FRS",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2961,
      "y" : 449
    },
    "minX" : 2899,
    "maxX" : 3402,
    "minY" : 382,
    "maxY" : 496,
    "prop" : {
      "x" : 2899,
      "y" : 426,
      "width" : 124,
      "height" : 46
    },
    "textPosition" : {
      "x" : 2904,
      "y" : 431
    },
    "connectors" : [ {
      "edgeId" : 8858,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3005,
          "y" : 478
        },
        "to" : {
          "x" : 3051,
          "y" : 496
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8864,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3000,
          "y" : 420
        },
        "to" : {
          "x" : 3076,
          "y" : 382
        }
      }, {
        "from" : {
          "x" : 3076,
          "y" : 382
        },
        "to" : {
          "x" : 3402,
          "y" : 389
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4509,
    "reactomeId" : 190915,
    "displayName" : "HS",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 197,
      "y" : 1051
    },
    "minX" : 63,
    "maxX" : 360,
    "minY" : 998,
    "maxY" : 1098,
    "prop" : {
      "x" : 141,
      "y" : 1033,
      "width" : 113,
      "height" : 36
    },
    "textPosition" : {
      "x" : 185,
      "y" : 1040
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 249,
          "y" : 1038
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 249,
          "y" : 1038
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 480,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 257,
          "y" : 1056
        },
        "to" : {
          "x" : 360,
          "y" : 1067
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 480,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 257,
          "y" : 1066
        },
        "to" : {
          "x" : 296,
          "y" : 1079
        }
      }, {
        "from" : {
          "x" : 296,
          "y" : 1079
        },
        "to" : {
          "x" : 353,
          "y" : 1096
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 345,
          "y" : 1098
        },
        "b" : {
          "x" : 353,
          "y" : 1096
        },
        "c" : {
          "x" : 348,
          "y" : 1090
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 348,
          "y" : 1090
        }
      }
    }, {
      "edgeId" : 13615,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 151,
          "y" : 1030
        },
        "to" : {
          "x" : 63,
          "y" : 998
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 8862,
    "reactomeId" : 5654264,
    "displayName" : "Activated FGFR1:p-FRS2:GRB2:SOS1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3201,
      "y" : 488
    },
    "minX" : 3146,
    "maxX" : 3370,
    "minY" : 455,
    "maxY" : 808,
    "prop" : {
      "x" : 3146,
      "y" : 461,
      "width" : 110,
      "height" : 54
    },
    "textPosition" : {
      "x" : 3152,
      "y" : 466
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3256,
          "y" : 461
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3256,
          "y" : 461
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8858,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8863,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3259,
          "y" : 502
        },
        "to" : {
          "x" : 3370,
          "y" : 534
        }
      }, {
        "from" : {
          "x" : 3370,
          "y" : 534
        },
        "to" : {
          "x" : 3328,
          "y" : 800
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3328,
          "y" : 804
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3328,
          "y" : 804
        }
      }
    } ]
  }, {
    "id" : 8865,
    "reactomeId" : 5654268,
    "displayName" : "Activated FGFR1:p-FRS:PTPN11",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3546,
      "y" : 399
    },
    "minX" : 3483,
    "maxX" : 3661,
    "minY" : 334,
    "maxY" : 424,
    "prop" : {
      "x" : 3483,
      "y" : 374,
      "width" : 127,
      "height" : 50
    },
    "textPosition" : {
      "x" : 3484,
      "y" : 389
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3610,
          "y" : 374
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3610,
          "y" : 374
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8864,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8866,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3613,
          "y" : 396
        },
        "to" : {
          "x" : 3637,
          "y" : 395
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8866,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3579,
          "y" : 371
        },
        "to" : {
          "x" : 3632,
          "y" : 334
        }
      }, {
        "from" : {
          "x" : 3632,
          "y" : 334
        },
        "to" : {
          "x" : 3655,
          "y" : 382
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3657,
          "y" : 385
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3657,
          "y" : 385
        }
      }
    } ]
  }, {
    "id" : 8868,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3720,
      "y" : 445
    },
    "minX" : 3690,
    "maxX" : 3742,
    "minY" : 396,
    "maxY" : 460,
    "prop" : {
      "x" : 3700,
      "y" : 430,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 3704,
      "y" : 434
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3736,
          "y" : 435
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3736,
          "y" : 435
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8866,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3710,
          "y" : 427
        },
        "to" : {
          "x" : 3690,
          "y" : 396
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 3694,
            "y" : 405
          },
          "b" : {
            "x" : 3706,
            "y" : 417
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3700,
            "y" : 411
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 3703,
          "y" : 423
        },
        "b" : {
          "x" : 3710,
          "y" : 427
        },
        "c" : {
          "x" : 3710,
          "y" : 419
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3710,
          "y" : 419
        }
      }
    } ]
  }, {
    "id" : 8869,
    "reactomeId" : 5654271,
    "displayName" : "Activated FGFR1:p-FRS:p-PTPN11",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3815,
      "y" : 397
    },
    "minX" : 3384,
    "maxX" : 3880,
    "minY" : 373,
    "maxY" : 743,
    "prop" : {
      "x" : 3757,
      "y" : 379,
      "width" : 117,
      "height" : 37
    },
    "textPosition" : {
      "x" : 3759,
      "y" : 381
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3874,
          "y" : 379
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3874,
          "y" : 379
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13847,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 3791,
          "y" : 419
        },
        "to" : {
          "x" : 3384,
          "y" : 743
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3387,
          "y" : 736
        },
        "b" : {
          "x" : 3384,
          "y" : 743
        },
        "c" : {
          "x" : 3392,
          "y" : 742
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 3392,
          "y" : 742
        }
      }
    }, {
      "edgeId" : 8866,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3754,
          "y" : 396
        },
        "to" : {
          "x" : 3690,
          "y" : 396
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3747,
          "y" : 400
        },
        "b" : {
          "x" : 3754,
          "y" : 396
        },
        "c" : {
          "x" : 3747,
          "y" : 392
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3747,
          "y" : 392
        }
      }
    } ]
  }, {
    "id" : 2479,
    "reactomeId" : 182964,
    "displayName" : "p-Y371-CBL:GRB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4984,
      "y" : 627
    },
    "minX" : 4929,
    "maxX" : 5109,
    "minY" : 518,
    "maxY" : 646,
    "prop" : {
      "x" : 4929,
      "y" : 608,
      "width" : 111,
      "height" : 38
    },
    "textPosition" : {
      "x" : 4944,
      "y" : 611
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5040,
          "y" : 608
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5040,
          "y" : 608
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8933,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 5005,
          "y" : 605
        },
        "to" : {
          "x" : 5109,
          "y" : 518
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 8881,
    "reactomeId" : 5654155,
    "displayName" : "activated FGFR1:PLCG1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1982,
      "y" : 240
    },
    "minX" : 1850,
    "maxX" : 2051,
    "minY" : 210,
    "maxY" : 279,
    "prop" : {
      "x" : 1919,
      "y" : 216,
      "width" : 126,
      "height" : 49
    },
    "textPosition" : {
      "x" : 1925,
      "y" : 230
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2045,
          "y" : 216
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2045,
          "y" : 216
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8880,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8882,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1916,
          "y" : 241
        },
        "to" : {
          "x" : 1870,
          "y" : 243
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8882,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1921,
          "y" : 268
        },
        "to" : {
          "x" : 1886,
          "y" : 279
        }
      }, {
        "from" : {
          "x" : 1886,
          "y" : 279
        },
        "to" : {
          "x" : 1857,
          "y" : 254
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1854,
          "y" : 251
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1854,
          "y" : 251
        }
      }
    } ]
  }, {
    "id" : 8883,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1899,
      "y" : 201
    },
    "minX" : 1870,
    "maxX" : 1927,
    "minY" : 186,
    "maxY" : 243,
    "prop" : {
      "x" : 1873,
      "y" : 187,
      "width" : 53,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1884,
      "y" : 191
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1921,
          "y" : 192
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1921,
          "y" : 192
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8882,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1888,
          "y" : 219
        },
        "to" : {
          "x" : 1870,
          "y" : 243
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1873,
            "y" : 225
          },
          "b" : {
            "x" : 1885,
            "y" : 237
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1879,
            "y" : 231
          }
        }
      }
    } ]
  }, {
    "id" : 8884,
    "reactomeId" : 5654154,
    "displayName" : "activated FGFR1:p-4Y-PLCG1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1714,
      "y" : 249
    },
    "minX" : 1658,
    "maxX" : 1807,
    "minY" : 214,
    "maxY" : 278,
    "prop" : {
      "x" : 1658,
      "y" : 220,
      "width" : 112,
      "height" : 58
    },
    "textPosition" : {
      "x" : 1673,
      "y" : 229
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1770,
          "y" : 220
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1770,
          "y" : 220
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8882,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1773,
          "y" : 246
        },
        "to" : {
          "x" : 1807,
          "y" : 245
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1780,
          "y" : 242
        },
        "b" : {
          "x" : 1773,
          "y" : 246
        },
        "c" : {
          "x" : 1780,
          "y" : 250
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1780,
          "y" : 250
        }
      }
    }, {
      "edgeId" : 8886,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 8885,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1789,
      "y" : 196
    },
    "minX" : 1758,
    "maxX" : 1821,
    "minY" : 183,
    "maxY" : 245,
    "prop" : {
      "x" : 1758,
      "y" : 184,
      "width" : 62,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1772,
      "y" : 186
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1815,
          "y" : 189
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1815,
          "y" : 189
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8882,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1793,
          "y" : 212
        },
        "to" : {
          "x" : 1807,
          "y" : 245
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1794,
            "y" : 222
          },
          "b" : {
            "x" : 1806,
            "y" : 234
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1800,
            "y" : 228
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1799,
          "y" : 217
        },
        "b" : {
          "x" : 1793,
          "y" : 212
        },
        "c" : {
          "x" : 1792,
          "y" : 220
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1792,
          "y" : 220
        }
      }
    } ]
  }, {
    "id" : 8888,
    "reactomeId" : 5654258,
    "displayName" : "Activated FGFR1:SHC1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2391,
      "y" : 557
    },
    "minX" : 2338,
    "maxX" : 2492,
    "minY" : 522,
    "maxY" : 581,
    "prop" : {
      "x" : 2338,
      "y" : 533,
      "width" : 107,
      "height" : 48
    },
    "textPosition" : {
      "x" : 2349,
      "y" : 546
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2445,
          "y" : 533
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2445,
          "y" : 533
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8887,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8889,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2448,
          "y" : 557
        },
        "to" : {
          "x" : 2469,
          "y" : 558
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8889,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2448,
          "y" : 534
        },
        "to" : {
          "x" : 2473,
          "y" : 522
        }
      }, {
        "from" : {
          "x" : 2473,
          "y" : 522
        },
        "to" : {
          "x" : 2486,
          "y" : 544
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2488,
          "y" : 548
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2488,
          "y" : 548
        }
      }
    } ]
  }, {
    "id" : 8890,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2444,
      "y" : 627
    },
    "minX" : 2415,
    "maxX" : 2475,
    "minY" : 558,
    "maxY" : 641,
    "prop" : {
      "x" : 2415,
      "y" : 613,
      "width" : 59,
      "height" : 28
    },
    "textPosition" : {
      "x" : 2429,
      "y" : 616
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2469,
          "y" : 618
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2469,
          "y" : 618
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8889,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2449,
          "y" : 610
        },
        "to" : {
          "x" : 2469,
          "y" : 558
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 2453,
            "y" : 578
          },
          "b" : {
            "x" : 2465,
            "y" : 590
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2459,
            "y" : 584
          }
        }
      }
    } ]
  }, {
    "id" : 8891,
    "reactomeId" : 5654273,
    "displayName" : "Activated FGFR1:p-SHC1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2608,
      "y" : 555
    },
    "minX" : 2517,
    "maxX" : 3066,
    "minY" : 521,
    "maxY" : 706,
    "prop" : {
      "x" : 2548,
      "y" : 527,
      "width" : 120,
      "height" : 56
    },
    "textPosition" : {
      "x" : 2551,
      "y" : 548
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2668,
          "y" : 527
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2668,
          "y" : 527
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8889,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2545,
          "y" : 556
        },
        "to" : {
          "x" : 2517,
          "y" : 558
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2538,
          "y" : 560
        },
        "b" : {
          "x" : 2545,
          "y" : 556
        },
        "c" : {
          "x" : 2538,
          "y" : 553
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2538,
          "y" : 553
        }
      }
    }, {
      "edgeId" : 8893,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2624,
          "y" : 586
        },
        "to" : {
          "x" : 2690,
          "y" : 698
        }
      }, {
        "from" : {
          "x" : 2690,
          "y" : 698
        },
        "to" : {
          "x" : 3066,
          "y" : 706
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 8892,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2552,
      "y" : 624
    },
    "minX" : 2517,
    "maxX" : 2583,
    "minY" : 558,
    "maxY" : 637,
    "prop" : {
      "x" : 2523,
      "y" : 611,
      "width" : 59,
      "height" : 26
    },
    "textPosition" : {
      "x" : 2536,
      "y" : 613
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2577,
          "y" : 616
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2577,
          "y" : 616
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8889,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2545,
          "y" : 608
        },
        "to" : {
          "x" : 2517,
          "y" : 558
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 2525,
            "y" : 577
          },
          "b" : {
            "x" : 2537,
            "y" : 589
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2531,
            "y" : 583
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2538,
          "y" : 604
        },
        "b" : {
          "x" : 2545,
          "y" : 608
        },
        "c" : {
          "x" : 2545,
          "y" : 600
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2545,
          "y" : 600
        }
      }
    } ]
  }, {
    "id" : 3005,
    "reactomeId" : 1489509,
    "displayName" : "DAG and IP3 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1474,
      "y" : 83
    },
    "minX" : 1411,
    "maxX" : 1537,
    "minY" : 55,
    "maxY" : 112,
    "prop" : {
      "x" : 1411,
      "y" : 55,
      "width" : 126,
      "height" : 57
    },
    "textPosition" : {
      "x" : 1425,
      "y" : 62
    },
    "connectors" : [ ]
  }, {
    "id" : 8894,
    "reactomeId" : 5654275,
    "displayName" : "Activated FGFR1:p-SHC1:GRB2:SOS1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3207,
      "y" : 554
    },
    "minX" : 3148,
    "maxX" : 3307,
    "minY" : 523,
    "maxY" : 773,
    "prop" : {
      "x" : 3148,
      "y" : 529,
      "width" : 119,
      "height" : 50
    },
    "textPosition" : {
      "x" : 3151,
      "y" : 530
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3267,
          "y" : 529
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3267,
          "y" : 529
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8893,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8895,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3218,
          "y" : 582
        },
        "to" : {
          "x" : 3301,
          "y" : 765
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3303,
          "y" : 769
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3303,
          "y" : 769
        }
      }
    } ]
  }, {
    "id" : 8897,
    "reactomeId" : 5654186,
    "displayName" : "Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4196,
      "y" : 406
    },
    "minX" : 4129,
    "maxX" : 4331,
    "minY" : 368,
    "maxY" : 439,
    "prop" : {
      "x" : 4129,
      "y" : 374,
      "width" : 134,
      "height" : 65
    },
    "textPosition" : {
      "x" : 4133,
      "y" : 390
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4263,
          "y" : 374
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4263,
          "y" : 374
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8896,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8907,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4266,
          "y" : 406
        },
        "to" : {
          "x" : 4331,
          "y" : 408
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 3009,
    "reactomeId" : 179838,
    "displayName" : "PI(3,4,5)P3",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2103,
      "y" : 315
    },
    "minX" : 2043,
    "maxX" : 2143,
    "minY" : 292,
    "maxY" : 343,
    "prop" : {
      "x" : 2065,
      "y" : 293,
      "width" : 77,
      "height" : 44
    },
    "textPosition" : {
      "x" : 2065,
      "y" : 304
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2137,
          "y" : 298
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2137,
          "y" : 298
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8880,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2062,
          "y" : 332
        },
        "to" : {
          "x" : 2043,
          "y" : 343
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2762,
    "reactomeId" : 1370875,
    "displayName" : "Ub-(Y55/Y227)p-SPRY2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6099,
      "y" : 2041
    },
    "minX" : 6042,
    "maxX" : 6163,
    "minY" : 1949,
    "maxY" : 2059,
    "prop" : {
      "x" : 6042,
      "y" : 2023,
      "width" : 115,
      "height" : 36
    },
    "textPosition" : {
      "x" : 6045,
      "y" : 2024
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6157,
          "y" : 2023
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6157,
          "y" : 2023
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2536,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6107,
          "y" : 2020
        },
        "to" : {
          "x" : 6144,
          "y" : 1949
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6107,
          "y" : 2012
        },
        "b" : {
          "x" : 6107,
          "y" : 2020
        },
        "c" : {
          "x" : 6114,
          "y" : 2016
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6114,
          "y" : 2016
        }
      }
    } ]
  }, {
    "id" : 8908,
    "reactomeId" : 5654205,
    "displayName" : "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4469,
      "y" : 407
    },
    "minX" : 4414,
    "maxX" : 4733,
    "minY" : 363,
    "maxY" : 460,
    "prop" : {
      "x" : 4414,
      "y" : 369,
      "width" : 110,
      "height" : 76
    },
    "textPosition" : {
      "x" : 4415,
      "y" : 396
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4524,
          "y" : 369
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4524,
          "y" : 369
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8907,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8909,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 4527,
          "y" : 400
        },
        "to" : {
          "x" : 4712,
          "y" : 378
        }
      }, {
        "from" : {
          "x" : 4712,
          "y" : 378
        },
        "to" : {
          "x" : 4728,
          "y" : 452
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 4729,
          "y" : 456
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4729,
          "y" : 456
        }
      }
    } ]
  }, {
    "id" : 8910,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4539,
      "y" : 607
    },
    "minX" : 4510,
    "maxX" : 4716,
    "minY" : 468,
    "maxY" : 618,
    "prop" : {
      "x" : 4510,
      "y" : 596,
      "width" : 58,
      "height" : 22
    },
    "textPosition" : {
      "x" : 4523,
      "y" : 596
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4563,
          "y" : 601
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4563,
          "y" : 601
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8909,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4552,
          "y" : 593
        },
        "to" : {
          "x" : 4705,
          "y" : 468
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8912,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4560,
          "y" : 593
        },
        "to" : {
          "x" : 4716,
          "y" : 517
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 8911,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4852,
      "y" : 613
    },
    "minX" : 4759,
    "maxX" : 4884,
    "minY" : 467,
    "maxY" : 628,
    "prop" : {
      "x" : 4822,
      "y" : 598,
      "width" : 61,
      "height" : 30
    },
    "textPosition" : {
      "x" : 4836,
      "y" : 602
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4878,
          "y" : 603
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4878,
          "y" : 603
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8909,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4842,
          "y" : 595
        },
        "to" : {
          "x" : 4759,
          "y" : 467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4835,
          "y" : 591
        },
        "b" : {
          "x" : 4842,
          "y" : 595
        },
        "c" : {
          "x" : 4842,
          "y" : 587
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4842,
          "y" : 587
        }
      }
    }, {
      "edgeId" : 8912,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4838,
          "y" : 595
        },
        "to" : {
          "x" : 4765,
          "y" : 517
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4830,
          "y" : 593
        },
        "b" : {
          "x" : 4838,
          "y" : 595
        },
        "c" : {
          "x" : 4836,
          "y" : 587
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4836,
          "y" : 587
        }
      }
    } ]
  }, {
    "id" : 8915,
    "reactomeId" : 5654188,
    "displayName" : "Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4473,
      "y" : 519
    },
    "minX" : 4412,
    "maxX" : 4730,
    "minY" : 432,
    "maxY" : 554,
    "prop" : {
      "x" : 4412,
      "y" : 485,
      "width" : 122,
      "height" : 69
    },
    "textPosition" : {
      "x" : 4413,
      "y" : 505
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4534,
          "y" : 485
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4534,
          "y" : 485
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8912,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 4531,
          "y" : 482
        },
        "to" : {
          "x" : 4620,
          "y" : 432
        }
      }, {
        "from" : {
          "x" : 4620,
          "y" : 432
        },
        "to" : {
          "x" : 4723,
          "y" : 509
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 4726,
          "y" : 512
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4726,
          "y" : 512
        }
      }
    }, {
      "edgeId" : 8919,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 468,
    "reactomeId" : 189963,
    "displayName" : "FGFR1b-binding FGFs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 124,
      "y" : 512
    },
    "minX" : 77,
    "maxX" : 480,
    "minY" : 497,
    "maxY" : 581,
    "prop" : {
      "x" : 77,
      "y" : 497,
      "width" : 94,
      "height" : 31
    },
    "textPosition" : {
      "x" : 80,
      "y" : 495
    },
    "connectors" : [ {
      "edgeId" : 467,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 177,
          "y" : 521
        },
        "to" : {
          "x" : 480,
          "y" : 581
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 322,
            "y" : 545
          },
          "b" : {
            "x" : 334,
            "y" : 557
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 328,
            "y" : 551
          }
        }
      }
    } ]
  }, {
    "id" : 8917,
    "reactomeId" : 5654204,
    "displayName" : "Activated FGFR1:p-FRS2:p-PTPN11",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3908,
      "y" : 493
    },
    "minX" : 3840,
    "maxX" : 5109,
    "minY" : 294,
    "maxY" : 526,
    "prop" : {
      "x" : 3840,
      "y" : 460,
      "width" : 136,
      "height" : 66
    },
    "textPosition" : {
      "x" : 3845,
      "y" : 491
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3976,
          "y" : 460
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3976,
          "y" : 460
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8916,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3979,
          "y" : 498
        },
        "to" : {
          "x" : 4057,
          "y" : 504
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8933,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3923,
          "y" : 457
        },
        "to" : {
          "x" : 4004,
          "y" : 294
        }
      }, {
        "from" : {
          "x" : 4004,
          "y" : 294
        },
        "to" : {
          "x" : 4967,
          "y" : 297
        }
      }, {
        "from" : {
          "x" : 4967,
          "y" : 297
        },
        "to" : {
          "x" : 5109,
          "y" : 518
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2518,
    "reactomeId" : 934576,
    "displayName" : "Y55/Y227-pSPRY2:CBL",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6219,
      "y" : 1672
    },
    "minX" : 6140,
    "maxX" : 6311,
    "minY" : 1568,
    "maxY" : 1774,
    "prop" : {
      "x" : 6140,
      "y" : 1654,
      "width" : 158,
      "height" : 37
    },
    "textPosition" : {
      "x" : 6147,
      "y" : 1670
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6298,
          "y" : 1654
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6298,
          "y" : 1654
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2521,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6205,
          "y" : 1651
        },
        "to" : {
          "x" : 6144,
          "y" : 1568
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6198,
          "y" : 1648
        },
        "b" : {
          "x" : 6205,
          "y" : 1651
        },
        "c" : {
          "x" : 6204,
          "y" : 1643
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6204,
          "y" : 1643
        }
      }
    }, {
      "edgeId" : 2523,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6218,
          "y" : 1694
        },
        "to" : {
          "x" : 6218,
          "y" : 1737
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2523,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 6244,
          "y" : 1694
        },
        "to" : {
          "x" : 6311,
          "y" : 1738
        }
      }, {
        "from" : {
          "x" : 6311,
          "y" : 1738
        },
        "to" : {
          "x" : 6239,
          "y" : 1769
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 6235,
          "y" : 1770
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6235,
          "y" : 1770
        }
      }
    } ]
  }, {
    "id" : 8918,
    "reactomeId" : 5654185,
    "displayName" : "Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4200,
      "y" : 517
    },
    "minX" : 4142,
    "maxX" : 4355,
    "minY" : 478,
    "maxY" : 550,
    "prop" : {
      "x" : 4142,
      "y" : 484,
      "width" : 116,
      "height" : 66
    },
    "textPosition" : {
      "x" : 4147,
      "y" : 487
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4258,
          "y" : 484
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4258,
          "y" : 484
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8916,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8919,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4261,
          "y" : 516
        },
        "to" : {
          "x" : 4355,
          "y" : 516
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 471,
    "reactomeId" : 190226,
    "displayName" : "FGFR1b homodimer bound to FGF",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 487,
      "y" : 667
    },
    "minX" : 422,
    "maxX" : 541,
    "minY" : 634,
    "maxY" : 754,
    "prop" : {
      "x" : 440,
      "y" : 640,
      "width" : 95,
      "height" : 54
    },
    "textPosition" : {
      "x" : 441,
      "y" : 645
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 535,
          "y" : 640
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 535,
          "y" : 640
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 467,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 474,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 487,
          "y" : 697
        },
        "to" : {
          "x" : 487,
          "y" : 727
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 474,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 462,
          "y" : 697
        },
        "to" : {
          "x" : 422,
          "y" : 739
        }
      }, {
        "from" : {
          "x" : 422,
          "y" : 739
        },
        "to" : {
          "x" : 468,
          "y" : 749
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 472,
          "y" : 750
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 472,
          "y" : 750
        }
      }
    } ]
  }, {
    "id" : 2522,
    "reactomeId" : 112199,
    "displayName" : "CBL",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 6133,
      "y" : 1475
    },
    "minX" : 5961,
    "maxX" : 6165,
    "minY" : 1458,
    "maxY" : 1949,
    "prop" : {
      "x" : 6107,
      "y" : 1464,
      "width" : 52,
      "height" : 23
    },
    "textPosition" : {
      "x" : 6118,
      "y" : 1465
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6159,
          "y" : 1464
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6159,
          "y" : 1464
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2521,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6135,
          "y" : 1490
        },
        "to" : {
          "x" : 6143,
          "y" : 1519
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2536,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6104,
          "y" : 1483
        },
        "to" : {
          "x" : 5961,
          "y" : 1529
        }
      }, {
        "from" : {
          "x" : 5961,
          "y" : 1529
        },
        "to" : {
          "x" : 5965,
          "y" : 1948
        }
      }, {
        "from" : {
          "x" : 5965,
          "y" : 1948
        },
        "to" : {
          "x" : 6144,
          "y" : 1949
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6099,
          "y" : 1489
        },
        "b" : {
          "x" : 6104,
          "y" : 1483
        },
        "c" : {
          "x" : 6096,
          "y" : 1481
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6096,
          "y" : 1481
        }
      }
    } ]
  }, {
    "id" : 2524,
    "reactomeId" : 934572,
    "displayName" : "Ub:Y55/Y227-pSPRY2:CBL",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 6227,
      "y" : 1863
    },
    "minX" : 6151,
    "maxX" : 6310,
    "minY" : 1835,
    "maxY" : 1885,
    "prop" : {
      "x" : 6151,
      "y" : 1841,
      "width" : 153,
      "height" : 44
    },
    "textPosition" : {
      "x" : 6156,
      "y" : 1850
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6304,
          "y" : 1841
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6304,
          "y" : 1841
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2523,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2536,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 476,
    "reactomeId" : 190430,
    "displayName" : "Activated FGFR1b homodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 497,
      "y" : 832
    },
    "minX" : 438,
    "maxX" : 563,
    "minY" : 775,
    "maxY" : 853,
    "prop" : {
      "x" : 438,
      "y" : 812,
      "width" : 119,
      "height" : 41
    },
    "textPosition" : {
      "x" : 437,
      "y" : 818
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 557,
          "y" : 812
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 557,
          "y" : 812
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 474,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 491,
          "y" : 809
        },
        "to" : {
          "x" : 483,
          "y" : 775
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 486,
          "y" : 803
        },
        "b" : {
          "x" : 491,
          "y" : 809
        },
        "c" : {
          "x" : 493,
          "y" : 801
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 493,
          "y" : 801
        }
      }
    } ]
  }, {
    "id" : 2271,
    "reactomeId" : 179838,
    "displayName" : "PI(3,4,5)P3",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4864,
      "y" : 512
    },
    "minX" : 4759,
    "maxX" : 4902,
    "minY" : 467,
    "maxY" : 527,
    "prop" : {
      "x" : 4827,
      "y" : 498,
      "width" : 74,
      "height" : 29
    },
    "textPosition" : {
      "x" : 4833,
      "y" : 495
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4896,
          "y" : 503
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4896,
          "y" : 503
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8909,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4830,
          "y" : 495
        },
        "to" : {
          "x" : 4759,
          "y" : 467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4822,
          "y" : 496
        },
        "b" : {
          "x" : 4830,
          "y" : 495
        },
        "c" : {
          "x" : 4825,
          "y" : 489
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4825,
          "y" : 489
        }
      }
    }, {
      "edgeId" : 8912,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 4824,
          "y" : 513
        },
        "to" : {
          "x" : 4765,
          "y" : 517
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 4817,
          "y" : 517
        },
        "b" : {
          "x" : 4824,
          "y" : 513
        },
        "c" : {
          "x" : 4817,
          "y" : 509
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 4817,
          "y" : 509
        }
      }
    } ]
  }, {
    "id" : 481,
    "reactomeId" : 189953,
    "displayName" : "FGFR1c-binding FGFs",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 164,
      "y" : 943
    },
    "minX" : 110,
    "maxX" : 360,
    "minY" : 925,
    "maxY" : 1067,
    "prop" : {
      "x" : 110,
      "y" : 925,
      "width" : 109,
      "height" : 36
    },
    "textPosition" : {
      "x" : 110,
      "y" : 925
    },
    "connectors" : [ {
      "edgeId" : 480,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 192,
          "y" : 967
        },
        "to" : {
          "x" : 360,
          "y" : 1067
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 270,
            "y" : 1011
          },
          "b" : {
            "x" : 282,
            "y" : 1023
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 276,
            "y" : 1017
          }
        }
      }
    } ]
  }, {
    "id" : 8930,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2691,
      "y" : 624
    },
    "minX" : 2662,
    "maxX" : 2721,
    "minY" : 543,
    "maxY" : 638,
    "prop" : {
      "x" : 2662,
      "y" : 611,
      "width" : 58,
      "height" : 27
    },
    "textPosition" : {
      "x" : 2675,
      "y" : 614
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2715,
          "y" : 616
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2715,
          "y" : 616
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8929,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2695,
          "y" : 608
        },
        "to" : {
          "x" : 2719,
          "y" : 543
        }
      } ],
      "stoichiometry" : {
        "value" : 8,
        "shape" : {
          "a" : {
            "x" : 2701,
            "y" : 569
          },
          "b" : {
            "x" : 2713,
            "y" : 581
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2707,
            "y" : 575
          }
        }
      }
    } ]
  }, {
    "id" : 483,
    "reactomeId" : 190233,
    "displayName" : "FGFR1c homodimer bound to FGF",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 360,
      "y" : 1279
    },
    "minX" : 294,
    "maxX" : 433,
    "minY" : 1255,
    "maxY" : 1340,
    "prop" : {
      "x" : 294,
      "y" : 1261,
      "width" : 133,
      "height" : 36
    },
    "textPosition" : {
      "x" : 294,
      "y" : 1262
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 427,
          "y" : 1261
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 427,
          "y" : 1261
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 480,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 487,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 359,
          "y" : 1300
        },
        "to" : {
          "x" : 358,
          "y" : 1323
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 487,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 333,
          "y" : 1300
        },
        "to" : {
          "x" : 302,
          "y" : 1319
        }
      }, {
        "from" : {
          "x" : 302,
          "y" : 1319
        },
        "to" : {
          "x" : 344,
          "y" : 1334
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 348,
          "y" : 1336
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 348,
          "y" : 1336
        }
      }
    } ]
  }, {
    "id" : 8931,
    "reactomeId" : 5654260,
    "displayName" : "Activated FGFR1:p-8T-FRS2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2890,
      "y" : 568
    },
    "minX" : 2796,
    "maxX" : 2955,
    "minY" : 535,
    "maxY" : 595,
    "prop" : {
      "x" : 2832,
      "y" : 541,
      "width" : 117,
      "height" : 54
    },
    "textPosition" : {
      "x" : 2834,
      "y" : 560
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2949,
          "y" : 541
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2949,
          "y" : 541
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8929,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2829,
          "y" : 552
        },
        "to" : {
          "x" : 2796,
          "y" : 543
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2821,
          "y" : 554
        },
        "b" : {
          "x" : 2829,
          "y" : 552
        },
        "c" : {
          "x" : 2823,
          "y" : 546
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2823,
          "y" : 546
        }
      }
    } ]
  }, {
    "id" : 8932,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2826,
      "y" : 637
    },
    "minX" : 2793,
    "maxX" : 2861,
    "minY" : 543,
    "maxY" : 650,
    "prop" : {
      "x" : 2793,
      "y" : 624,
      "width" : 67,
      "height" : 26
    },
    "textPosition" : {
      "x" : 2810,
      "y" : 626
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2855,
          "y" : 629
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2855,
          "y" : 629
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8929,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2821,
          "y" : 621
        },
        "to" : {
          "x" : 2796,
          "y" : 543
        }
      } ],
      "stoichiometry" : {
        "value" : 8,
        "shape" : {
          "a" : {
            "x" : 2802,
            "y" : 576
          },
          "b" : {
            "x" : 2814,
            "y" : 588
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2808,
            "y" : 582
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2815,
          "y" : 616
        },
        "b" : {
          "x" : 2821,
          "y" : 621
        },
        "c" : {
          "x" : 2823,
          "y" : 613
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2823,
          "y" : 613
        }
      }
    } ]
  }, {
    "id" : 2277,
    "reactomeId" : 74789,
    "displayName" : "PIK3R1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4131,
      "y" : 753
    },
    "minX" : 4054,
    "maxX" : 4185,
    "minY" : 717,
    "maxY" : 765,
    "prop" : {
      "x" : 4083,
      "y" : 742,
      "width" : 96,
      "height" : 23
    },
    "textPosition" : {
      "x" : 4106,
      "y" : 743
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4179,
          "y" : 742
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4179,
          "y" : 742
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2276,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4106,
          "y" : 739
        },
        "to" : {
          "x" : 4054,
          "y" : 717
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2278,
    "reactomeId" : 179864,
    "displayName" : "GRB2:GAB1:PIK3R1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 4039,
      "y" : 626
    },
    "minX" : 3997,
    "maxX" : 4088,
    "minY" : 321,
    "maxY" : 645,
    "prop" : {
      "x" : 3997,
      "y" : 607,
      "width" : 85,
      "height" : 38
    },
    "textPosition" : {
      "x" : 3998,
      "y" : 610
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4082,
          "y" : 607
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4082,
          "y" : 607
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8896,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4037,
          "y" : 604
        },
        "to" : {
          "x" : 4022,
          "y" : 321
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8916,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4041,
          "y" : 604
        },
        "to" : {
          "x" : 4057,
          "y" : 504
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2276,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 8934,
    "reactomeId" : 5654267,
    "displayName" : "Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 5258,
      "y" : 504
    },
    "minX" : 5175,
    "maxX" : 5411,
    "minY" : 468,
    "maxY" : 533,
    "prop" : {
      "x" : 5175,
      "y" : 475,
      "width" : 166,
      "height" : 58
    },
    "textPosition" : {
      "x" : 5178,
      "y" : 498
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5341,
          "y" : 475
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5341,
          "y" : 475
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8933,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8944,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 5344,
          "y" : 507
        },
        "to" : {
          "x" : 5381,
          "y" : 509
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8944,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 5344,
          "y" : 480
        },
        "to" : {
          "x" : 5384,
          "y" : 468
        }
      }, {
        "from" : {
          "x" : 5384,
          "y" : 468
        },
        "to" : {
          "x" : 5405,
          "y" : 497
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 5407,
          "y" : 500
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5407,
          "y" : 500
        }
      }
    } ]
  }, {
    "id" : 489,
    "reactomeId" : 190425,
    "displayName" : "Activated FGFR1c homodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 359,
      "y" : 1405
    },
    "minX" : 300,
    "maxX" : 425,
    "minY" : 1355,
    "maxY" : 1432,
    "prop" : {
      "x" : 300,
      "y" : 1379,
      "width" : 119,
      "height" : 53
    },
    "textPosition" : {
      "x" : 300,
      "y" : 1397
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 419,
          "y" : 1379
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 419,
          "y" : 1379
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 487,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 358,
          "y" : 1376
        },
        "to" : {
          "x" : 358,
          "y" : 1355
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 354,
          "y" : 1369
        },
        "b" : {
          "x" : 358,
          "y" : 1376
        },
        "c" : {
          "x" : 362,
          "y" : 1369
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 362,
          "y" : 1369
        }
      }
    } ]
  }, {
    "id" : 2285,
    "reactomeId" : 74787,
    "displayName" : "PIK3CA",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 4332,
      "y" : 643
    },
    "minX" : 4277,
    "maxX" : 4393,
    "minY" : 408,
    "maxY" : 661,
    "prop" : {
      "x" : 4277,
      "y" : 626,
      "width" : 110,
      "height" : 35
    },
    "textPosition" : {
      "x" : 4307,
      "y" : 633
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4387,
          "y" : 626
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4387,
          "y" : 626
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8907,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4331,
          "y" : 623
        },
        "to" : {
          "x" : 4331,
          "y" : 408
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8919,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4335,
          "y" : 623
        },
        "to" : {
          "x" : 4355,
          "y" : 516
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 495,
    "reactomeId" : 190208,
    "displayName" : "Klotho bound to FGF23",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 192,
      "y" : 1540
    },
    "minX" : 145,
    "maxX" : 359,
    "minY" : 1515,
    "maxY" : 1587,
    "prop" : {
      "x" : 145,
      "y" : 1521,
      "width" : 94,
      "height" : 38
    },
    "textPosition" : {
      "x" : 145,
      "y" : 1524
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 239,
          "y" : 1521
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 239,
          "y" : 1521
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 494,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 242,
          "y" : 1553
        },
        "to" : {
          "x" : 359,
          "y" : 1587
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 294,
            "y" : 1564
          },
          "b" : {
            "x" : 306,
            "y" : 1576
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 300,
            "y" : 1570
          }
        }
      }
    } ]
  }, {
    "id" : 496,
    "reactomeId" : 190218,
    "displayName" : "FGF23 bound to Klotho and FGFR1c",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 364,
      "y" : 1687
    },
    "minX" : 310,
    "maxX" : 425,
    "minY" : 1655,
    "maxY" : 1756,
    "prop" : {
      "x" : 310,
      "y" : 1661,
      "width" : 109,
      "height" : 52
    },
    "textPosition" : {
      "x" : 309,
      "y" : 1664
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 419,
          "y" : 1661
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 419,
          "y" : 1661
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 494,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 822,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 365,
          "y" : 1716
        },
        "to" : {
          "x" : 367,
          "y" : 1736
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 822,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 348,
          "y" : 1716
        },
        "to" : {
          "x" : 330,
          "y" : 1745
        }
      }, {
        "from" : {
          "x" : 330,
          "y" : 1745
        },
        "to" : {
          "x" : 353,
          "y" : 1751
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 356,
          "y" : 1752
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 356,
          "y" : 1752
        }
      }
    } ]
  }, {
    "id" : 8945,
    "reactomeId" : 5654357,
    "displayName" : "Ub-Activated FGFR1 complex:Ub-p-FRS2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 5522,
      "y" : 512
    },
    "minX" : 5458,
    "maxX" : 5592,
    "minY" : 475,
    "maxY" : 543,
    "prop" : {
      "x" : 5458,
      "y" : 481,
      "width" : 128,
      "height" : 62
    },
    "textPosition" : {
      "x" : 5458,
      "y" : 494
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5586,
          "y" : 481
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5586,
          "y" : 481
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8944,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2291,
    "reactomeId" : 179856,
    "displayName" : "PI(4,5)P2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 4577,
      "y" : 506
    },
    "minX" : 4541,
    "maxX" : 4716,
    "minY" : 468,
    "maxY" : 521,
    "prop" : {
      "x" : 4541,
      "y" : 492,
      "width" : 72,
      "height" : 29
    },
    "textPosition" : {
      "x" : 4544,
      "y" : 496
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 4608,
          "y" : 497
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 4608,
          "y" : 497
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8909,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4616,
          "y" : 495
        },
        "to" : {
          "x" : 4705,
          "y" : 468
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 8912,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 4616,
          "y" : 508
        },
        "to" : {
          "x" : 4716,
          "y" : 517
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1523,
    "reactomeId" : 74686,
    "displayName" : "GRB2-1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 6132,
      "y" : 1327
    },
    "minX" : 6052,
    "maxX" : 6234,
    "minY" : 1264,
    "maxY" : 1348,
    "prop" : {
      "x" : 6103,
      "y" : 1306,
      "width" : 59,
      "height" : 42
    },
    "textPosition" : {
      "x" : 6106,
      "y" : 1316
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 6162,
          "y" : 1306
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 6162,
          "y" : 1306
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2514,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 6165,
          "y" : 1309
        },
        "to" : {
          "x" : 6234,
          "y" : 1265
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 3037,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 6105,
          "y" : 1303
        },
        "to" : {
          "x" : 6052,
          "y" : 1264
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 6097,
          "y" : 1302
        },
        "b" : {
          "x" : 6105,
          "y" : 1303
        },
        "c" : {
          "x" : 6102,
          "y" : 1296
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 6102,
          "y" : 1296
        }
      }
    } ]
  }, {
    "id" : 2554,
    "reactomeId" : 65043,
    "displayName" : "SRC-1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 5858,
      "y" : 1062
    },
    "minX" : 5817,
    "maxX" : 5910,
    "minY" : 1042,
    "maxY" : 1135,
    "prop" : {
      "x" : 5817,
      "y" : 1048,
      "width" : 83,
      "height" : 29
    },
    "textPosition" : {
      "x" : 5836,
      "y" : 1052
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 5900,
          "y" : 1048
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5900,
          "y" : 1048
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2550,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 5868,
          "y" : 1080
        },
        "to" : {
          "x" : 5904,
          "y" : 1128
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 5906,
          "y" : 1131
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 5906,
          "y" : 1131
        }
      }
    } ]
  }, {
    "id" : 1534,
    "reactomeId" : 167682,
    "displayName" : "PLCG1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1938,
      "y" : 370
    },
    "minX" : 1888,
    "maxX" : 2043,
    "minY" : 343,
    "maxY" : 389,
    "prop" : {
      "x" : 1888,
      "y" : 351,
      "width" : 100,
      "height" : 38
    },
    "textPosition" : {
      "x" : 1914,
      "y" : 359
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1988,
          "y" : 351
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1988,
          "y" : 351
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 8880,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1991,
          "y" : 357
        },
        "to" : {
          "x" : 2043,
          "y" : 343
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 8896,
    "reactomeId" : 5654592,
    "displayName" : "Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4089,
      "y" : 385
    },
    "minX" : 4022,
    "maxX" : 4126,
    "minY" : 321,
    "maxY" : 392,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4022,
        "y" : 321
      },
      "to" : {
        "x" : 4089,
        "y" : 385
      }
    }, {
      "from" : {
        "x" : 4089,
        "y" : 385
      },
      "to" : {
        "x" : 4126,
        "y" : 392
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4118,
        "y" : 395
      },
      "b" : {
        "x" : 4126,
        "y" : 392
      },
      "c" : {
        "x" : 4120,
        "y" : 387
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4120,
        "y" : 387
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4089,
        "y" : 385
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4089,
        "y" : 385
      }
    },
    "inputs" : [ {
      "id" : 2278,
      "points" : [ {
        "x" : 4037,
        "y" : 604
      } ]
    }, {
      "id" : 8853,
      "points" : [ {
        "x" : 2842,
        "y" : 351
      }, {
        "x" : 2966,
        "y" : 317
      } ]
    } ],
    "outputs" : [ {
      "id" : 8897
    } ]
  }, {
    "id" : 8832,
    "reactomeId" : 5654569,
    "displayName" : "Activated FGFR1 binds FRS2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2349,
      "y" : 343
    },
    "minX" : 2302,
    "maxX" : 2409,
    "minY" : 338,
    "maxY" : 348,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2302,
        "y" : 341
      },
      "to" : {
        "x" : 2349,
        "y" : 343
      }
    }, {
      "from" : {
        "x" : 2349,
        "y" : 343
      },
      "to" : {
        "x" : 2409,
        "y" : 345
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2402,
        "y" : 349
      },
      "b" : {
        "x" : 2409,
        "y" : 345
      },
      "c" : {
        "x" : 2402,
        "y" : 341
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2402,
        "y" : 341
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2349,
        "y" : 343
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2349,
        "y" : 343
      }
    },
    "inputs" : [ {
      "id" : 2125,
      "points" : [ {
        "x" : 2309,
        "y" : 384
      } ]
    }, {
      "id" : 8833,
      "points" : [ {
        "x" : 2194,
        "y" : 397
      } ]
    } ],
    "outputs" : [ {
      "id" : 8838
    } ]
  }, {
    "id" : 8839,
    "reactomeId" : 5654571,
    "displayName" : "Activated FGFR1 binds FRS3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2365,
      "y" : 260
    },
    "minX" : 2332,
    "maxX" : 2406,
    "minY" : 255,
    "maxY" : 265,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2332,
        "y" : 258
      },
      "to" : {
        "x" : 2365,
        "y" : 260
      }
    }, {
      "from" : {
        "x" : 2365,
        "y" : 260
      },
      "to" : {
        "x" : 2406,
        "y" : 259
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2399,
        "y" : 263
      },
      "b" : {
        "x" : 2406,
        "y" : 259
      },
      "c" : {
        "x" : 2399,
        "y" : 255
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2399,
        "y" : 255
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2365,
        "y" : 260
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2365,
        "y" : 260
      }
    },
    "inputs" : [ {
      "id" : 2127,
      "points" : [ {
        "x" : 2298,
        "y" : 239
      } ]
    }, {
      "id" : 8833,
      "points" : [ {
        "x" : 2186,
        "y" : 397
      } ]
    } ],
    "outputs" : [ {
      "id" : 8840
    } ]
  }, {
    "id" : 8907,
    "reactomeId" : 5654591,
    "displayName" : "Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4375,
      "y" : 410
    },
    "minX" : 4331,
    "maxX" : 4411,
    "minY" : 405,
    "maxY" : 415,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4331,
        "y" : 408
      },
      "to" : {
        "x" : 4375,
        "y" : 410
      }
    }, {
      "from" : {
        "x" : 4375,
        "y" : 410
      },
      "to" : {
        "x" : 4411,
        "y" : 408
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4404,
        "y" : 412
      },
      "b" : {
        "x" : 4411,
        "y" : 408
      },
      "c" : {
        "x" : 4404,
        "y" : 404
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4404,
        "y" : 404
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4375,
        "y" : 410
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4375,
        "y" : 410
      }
    },
    "inputs" : [ {
      "id" : 8897,
      "points" : [ {
        "x" : 4266,
        "y" : 406
      } ]
    }, {
      "id" : 2285,
      "points" : [ {
        "x" : 4331,
        "y" : 623
      } ]
    } ],
    "outputs" : [ {
      "id" : 8908
    } ]
  }, {
    "id" : 13067,
    "reactomeId" : 5654511,
    "displayName" : "FGFRL1 dimer binds FGFs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 353,
      "y" : 2048
    },
    "minX" : 348,
    "maxX" : 358,
    "minY" : 1998,
    "maxY" : 2100,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 351,
        "y" : 1998
      },
      "to" : {
        "x" : 353,
        "y" : 2048
      }
    }, {
      "from" : {
        "x" : 353,
        "y" : 2048
      },
      "to" : {
        "x" : 353,
        "y" : 2100
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 349,
        "y" : 2093
      },
      "b" : {
        "x" : 353,
        "y" : 2100
      },
      "c" : {
        "x" : 357,
        "y" : 2093
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 357,
        "y" : 2093
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 353,
        "y" : 2048
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 353,
        "y" : 2048
      }
    },
    "inputs" : [ {
      "id" : 13060,
      "points" : [ {
        "x" : 351,
        "y" : 1943
      } ]
    }, {
      "id" : 13061,
      "points" : [ {
        "x" : 196,
        "y" : 1901
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 13066,
      "points" : [ {
        "x" : 226,
        "y" : 1992
      } ]
    } ],
    "outputs" : [ {
      "id" : 13064
    } ]
  }, {
    "id" : 8909,
    "reactomeId" : 5654690,
    "displayName" : "FGFR1-associated PI3K phosphorylates PIP2 to PIP3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4731,
      "y" : 468
    },
    "minX" : 4705,
    "maxX" : 4759,
    "minY" : 462,
    "maxY" : 474,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 4705,
        "y" : 468
      },
      "to" : {
        "x" : 4731,
        "y" : 468
      }
    }, {
      "from" : {
        "x" : 4731,
        "y" : 468
      },
      "to" : {
        "x" : 4759,
        "y" : 467
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4725,
        "y" : 462
      },
      "b" : {
        "x" : 4737,
        "y" : 474
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4731,
        "y" : 468
      }
    },
    "inputs" : [ {
      "id" : 2291,
      "points" : [ {
        "x" : 4616,
        "y" : 495
      } ]
    }, {
      "id" : 8910,
      "points" : [ {
        "x" : 4552,
        "y" : 593
      } ]
    } ],
    "outputs" : [ {
      "id" : 8911,
      "points" : [ {
        "x" : 4842,
        "y" : 595
      } ]
    }, {
      "id" : 2271,
      "points" : [ {
        "x" : 4830,
        "y" : 495
      } ]
    } ],
    "catalysts" : [ {
      "id" : 8908,
      "points" : [ {
        "x" : 4527,
        "y" : 400
      }, {
        "x" : 4712,
        "y" : 378
      } ]
    } ]
  }, {
    "id" : 8912,
    "reactomeId" : 5654692,
    "displayName" : "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4736,
      "y" : 519
    },
    "minX" : 4716,
    "maxX" : 4765,
    "minY" : 513,
    "maxY" : 525,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 4716,
        "y" : 517
      },
      "to" : {
        "x" : 4736,
        "y" : 519
      }
    }, {
      "from" : {
        "x" : 4736,
        "y" : 519
      },
      "to" : {
        "x" : 4765,
        "y" : 517
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 4730,
        "y" : 513
      },
      "b" : {
        "x" : 4742,
        "y" : 525
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4736,
        "y" : 519
      }
    },
    "inputs" : [ {
      "id" : 2291,
      "points" : [ {
        "x" : 4616,
        "y" : 508
      } ]
    }, {
      "id" : 8910,
      "points" : [ {
        "x" : 4560,
        "y" : 593
      } ]
    } ],
    "outputs" : [ {
      "id" : 2271,
      "points" : [ {
        "x" : 4824,
        "y" : 513
      } ]
    }, {
      "id" : 8911,
      "points" : [ {
        "x" : 4838,
        "y" : 595
      } ]
    } ],
    "catalysts" : [ {
      "id" : 8915,
      "points" : [ {
        "x" : 4531,
        "y" : 482
      }, {
        "x" : 4620,
        "y" : 432
      } ]
    } ]
  }, {
    "id" : 2514,
    "reactomeId" : 1295613,
    "displayName" : "SPRY2 binds GRB2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6234,
      "y" : 1292
    },
    "minX" : 6229,
    "maxX" : 6239,
    "minY" : 1265,
    "maxY" : 1395,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 6234,
        "y" : 1265
      },
      "to" : {
        "x" : 6234,
        "y" : 1292
      }
    }, {
      "from" : {
        "x" : 6234,
        "y" : 1292
      },
      "to" : {
        "x" : 6232,
        "y" : 1395
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 6228,
        "y" : 1388
      },
      "b" : {
        "x" : 6232,
        "y" : 1395
      },
      "c" : {
        "x" : 6236,
        "y" : 1388
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 6236,
        "y" : 1388
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 6234,
        "y" : 1292
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 6234,
        "y" : 1292
      }
    },
    "inputs" : [ {
      "id" : 2576,
      "points" : [ {
        "x" : 6234,
        "y" : 1231
      } ]
    }, {
      "id" : 1523,
      "points" : [ {
        "x" : 6165,
        "y" : 1309
      } ]
    } ],
    "outputs" : [ {
      "id" : 2578
    } ]
  }, {
    "id" : 8850,
    "reactomeId" : 5654575,
    "displayName" : "Activated FGFR1 phosphorylates FRS2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2604,
      "y" : 354
    },
    "minX" : 2578,
    "maxX" : 2634,
    "minY" : 348,
    "maxY" : 360,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2578,
        "y" : 356
      },
      "to" : {
        "x" : 2604,
        "y" : 354
      }
    }, {
      "from" : {
        "x" : 2604,
        "y" : 354
      },
      "to" : {
        "x" : 2634,
        "y" : 355
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2598,
        "y" : 348
      },
      "b" : {
        "x" : 2610,
        "y" : 360
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2604,
        "y" : 354
      }
    },
    "inputs" : [ {
      "id" : 8838,
      "points" : [ {
        "x" : 2522,
        "y" : 351
      } ]
    }, {
      "id" : 8851,
      "points" : [ {
        "x" : 2566,
        "y" : 335
      } ],
      "stoichiometry" : 6
    } ],
    "outputs" : [ {
      "id" : 8852,
      "points" : [ {
        "x" : 2654,
        "y" : 338
      } ],
      "stoichiometry" : 6
    }, {
      "id" : 8853,
      "points" : [ {
        "x" : 2717,
        "y" : 362
      } ]
    } ],
    "catalysts" : [ {
      "id" : 8838,
      "points" : [ {
        "x" : 2498,
        "y" : 368
      }, {
        "x" : 2547,
        "y" : 391
      } ]
    } ]
  }, {
    "id" : 467,
    "reactomeId" : 190245,
    "displayName" : "FGFR1b binds to FGF",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 480,
      "y" : 600
    },
    "minX" : 475,
    "maxX" : 485,
    "minY" : 581,
    "maxY" : 637,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 480,
        "y" : 581
      },
      "to" : {
        "x" : 480,
        "y" : 600
      }
    }, {
      "from" : {
        "x" : 480,
        "y" : 600
      },
      "to" : {
        "x" : 484,
        "y" : 637
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 479,
        "y" : 631
      },
      "b" : {
        "x" : 484,
        "y" : 637
      },
      "c" : {
        "x" : 487,
        "y" : 630
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 487,
        "y" : 630
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 480,
        "y" : 600
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 480,
        "y" : 600
      }
    },
    "inputs" : [ {
      "id" : 2401,
      "points" : [ {
        "x" : 458,
        "y" : 432
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 468,
      "points" : [ {
        "x" : 177,
        "y" : 521
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 4504,
      "points" : [ {
        "x" : 186,
        "y" : 586
      } ]
    } ],
    "outputs" : [ {
      "id" : 471
    } ],
    "activators" : [ {
      "id" : 4504,
      "points" : [ {
        "x" : 186,
        "y" : 598
      }, {
        "x" : 391,
        "y" : 648
      } ]
    }, {
      "id" : 13874,
      "points" : [ {
        "x" : 773,
        "y" : 491
      } ]
    } ]
  }, {
    "id" : 8916,
    "reactomeId" : 5654594,
    "displayName" : "Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4102,
      "y" : 504
    },
    "minX" : 4057,
    "maxX" : 4139,
    "minY" : 499,
    "maxY" : 509,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4057,
        "y" : 504
      },
      "to" : {
        "x" : 4102,
        "y" : 504
      }
    }, {
      "from" : {
        "x" : 4102,
        "y" : 504
      },
      "to" : {
        "x" : 4139,
        "y" : 509
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4132,
        "y" : 512
      },
      "b" : {
        "x" : 4139,
        "y" : 509
      },
      "c" : {
        "x" : 4133,
        "y" : 504
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4133,
        "y" : 504
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4102,
        "y" : 504
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4102,
        "y" : 504
      }
    },
    "inputs" : [ {
      "id" : 2278,
      "points" : [ {
        "x" : 4041,
        "y" : 604
      } ]
    }, {
      "id" : 8917,
      "points" : [ {
        "x" : 3979,
        "y" : 498
      } ]
    } ],
    "outputs" : [ {
      "id" : 8918
    } ]
  }, {
    "id" : 8854,
    "reactomeId" : 5654578,
    "displayName" : "Activated FGFR1 phosphorylates FRS3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2608,
      "y" : 253
    },
    "minX" : 2584,
    "maxX" : 2635,
    "minY" : 247,
    "maxY" : 259,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2584,
        "y" : 253
      },
      "to" : {
        "x" : 2608,
        "y" : 253
      }
    }, {
      "from" : {
        "x" : 2608,
        "y" : 253
      },
      "to" : {
        "x" : 2635,
        "y" : 252
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2602,
        "y" : 247
      },
      "b" : {
        "x" : 2614,
        "y" : 259
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2608,
        "y" : 253
      }
    },
    "inputs" : [ {
      "id" : 8840,
      "points" : [ {
        "x" : 2521,
        "y" : 255
      } ]
    }, {
      "id" : 8851,
      "points" : [ {
        "x" : 2564,
        "y" : 300
      } ],
      "stoichiometry" : 5
    } ],
    "outputs" : [ {
      "id" : 8856,
      "points" : [ {
        "x" : 2725,
        "y" : 253
      } ]
    }, {
      "id" : 8852,
      "points" : [ {
        "x" : 2661,
        "y" : 302
      } ],
      "stoichiometry" : 5
    } ],
    "catalysts" : [ {
      "id" : 8840,
      "points" : [ {
        "x" : 2479,
        "y" : 229
      }, {
        "x" : 2521,
        "y" : 165
      } ]
    } ]
  }, {
    "id" : 8919,
    "reactomeId" : 5654596,
    "displayName" : "Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4386,
      "y" : 516
    },
    "minX" : 4355,
    "maxX" : 4409,
    "minY" : 511,
    "maxY" : 521,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4355,
        "y" : 516
      },
      "to" : {
        "x" : 4386,
        "y" : 516
      }
    }, {
      "from" : {
        "x" : 4386,
        "y" : 516
      },
      "to" : {
        "x" : 4409,
        "y" : 516
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4402,
        "y" : 520
      },
      "b" : {
        "x" : 4409,
        "y" : 516
      },
      "c" : {
        "x" : 4402,
        "y" : 512
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4402,
        "y" : 512
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4386,
        "y" : 516
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4386,
        "y" : 516
      }
    },
    "inputs" : [ {
      "id" : 8918,
      "points" : [ {
        "x" : 4261,
        "y" : 516
      } ]
    }, {
      "id" : 2285,
      "points" : [ {
        "x" : 4335,
        "y" : 623
      } ]
    } ],
    "outputs" : [ {
      "id" : 8915
    } ]
  }, {
    "id" : 13847,
    "reactomeId" : 8941623,
    "displayName" : "Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3377,
      "y" : 749
    },
    "minX" : 3278,
    "maxX" : 3426,
    "minY" : 743,
    "maxY" : 755,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3278,
        "y" : 749
      },
      "to" : {
        "x" : 3377,
        "y" : 749
      }
    }, {
      "from" : {
        "x" : 3377,
        "y" : 749
      },
      "to" : {
        "x" : 3426,
        "y" : 749
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3371,
        "y" : 743
      },
      "b" : {
        "x" : 3383,
        "y" : 755
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3377,
        "y" : 749
      }
    },
    "inputs" : [ {
      "id" : 2326,
      "points" : [ {
        "x" : 3188,
        "y" : 870
      } ]
    }, {
      "id" : 2319,
      "points" : [ {
        "x" : 3206,
        "y" : 773
      } ]
    } ],
    "outputs" : [ {
      "id" : 2325,
      "points" : [ {
        "x" : 3429,
        "y" : 849
      } ]
    }, {
      "id" : 2320,
      "points" : [ {
        "x" : 3479,
        "y" : 768
      } ]
    } ],
    "activators" : [ {
      "id" : 8869,
      "points" : [ {
        "x" : 3791,
        "y" : 419
      } ]
    } ]
  }, {
    "id" : 2521,
    "reactomeId" : 1295622,
    "displayName" : "SPRY2 binds CBL",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6144,
      "y" : 1545
    },
    "minX" : 6139,
    "maxX" : 6149,
    "minY" : 1519,
    "maxY" : 1568,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 6143,
        "y" : 1519
      },
      "to" : {
        "x" : 6144,
        "y" : 1545
      }
    }, {
      "from" : {
        "x" : 6144,
        "y" : 1545
      },
      "to" : {
        "x" : 6144,
        "y" : 1568
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 6138,
        "y" : 1539
      },
      "b" : {
        "x" : 6150,
        "y" : 1551
      },
      "s" : "",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 6144,
        "y" : 1545
      }
    },
    "inputs" : [ {
      "id" : 2522,
      "points" : [ {
        "x" : 6135,
        "y" : 1490
      } ]
    }, {
      "id" : 2576,
      "points" : [ {
        "x" : 6269,
        "y" : 1231
      }, {
        "x" : 6308,
        "y" : 1246
      }, {
        "x" : 6305,
        "y" : 1456
      } ]
    } ],
    "outputs" : [ {
      "id" : 2518,
      "points" : [ {
        "x" : 6205,
        "y" : 1651
      } ]
    }, {
      "id" : 2579,
      "points" : [ {
        "x" : 6095,
        "y" : 1609
      } ]
    } ]
  }, {
    "id" : 474,
    "reactomeId" : 190427,
    "displayName" : "Autocatalytic phosphorylation of FGFR1b",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 484,
      "y" : 752
    },
    "minX" : 478,
    "maxX" : 490,
    "minY" : 727,
    "maxY" : 775,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 487,
        "y" : 727
      },
      "to" : {
        "x" : 484,
        "y" : 752
      }
    }, {
      "from" : {
        "x" : 484,
        "y" : 752
      },
      "to" : {
        "x" : 483,
        "y" : 775
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 478,
        "y" : 746
      },
      "b" : {
        "x" : 490,
        "y" : 758
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 484,
        "y" : 752
      }
    },
    "inputs" : [ {
      "id" : 471,
      "points" : [ {
        "x" : 487,
        "y" : 697
      } ]
    }, {
      "id" : 13655,
      "points" : [ {
        "x" : 550,
        "y" : 715
      } ],
      "stoichiometry" : 16
    } ],
    "outputs" : [ {
      "id" : 476,
      "points" : [ {
        "x" : 491,
        "y" : 809
      } ]
    }, {
      "id" : 13656,
      "points" : [ {
        "x" : 537,
        "y" : 787
      } ],
      "stoichiometry" : 16
    } ],
    "catalysts" : [ {
      "id" : 471,
      "points" : [ {
        "x" : 462,
        "y" : 697
      }, {
        "x" : 422,
        "y" : 739
      } ]
    } ]
  }, {
    "id" : 8858,
    "reactomeId" : 5654586,
    "displayName" : "Activated FGFR1:p-FRS binds GRB2:SOS1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3094,
      "y" : 493
    },
    "minX" : 3051,
    "maxX" : 3143,
    "minY" : 488,
    "maxY" : 498,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3051,
        "y" : 496
      },
      "to" : {
        "x" : 3094,
        "y" : 493
      }
    }, {
      "from" : {
        "x" : 3094,
        "y" : 493
      },
      "to" : {
        "x" : 3143,
        "y" : 490
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3136,
        "y" : 494
      },
      "b" : {
        "x" : 3143,
        "y" : 490
      },
      "c" : {
        "x" : 3136,
        "y" : 486
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3136,
        "y" : 486
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3094,
        "y" : 493
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3094,
        "y" : 493
      }
    },
    "inputs" : [ {
      "id" : 1576,
      "points" : [ {
        "x" : 3024,
        "y" : 604
      } ]
    }, {
      "id" : 8859,
      "points" : [ {
        "x" : 3005,
        "y" : 478
      } ]
    } ],
    "outputs" : [ {
      "id" : 8862
    } ]
  }, {
    "id" : 2651,
    "reactomeId" : 1295634,
    "displayName" : "SPRY2 is serine phosphorylated in response to MAPK activation",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3598,
      "y" : 1129
    },
    "minX" : 3530,
    "maxX" : 3627,
    "minY" : 1123,
    "maxY" : 1135,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 3530,
        "y" : 1128
      },
      "to" : {
        "x" : 3598,
        "y" : 1129
      }
    }, {
      "from" : {
        "x" : 3598,
        "y" : 1129
      },
      "to" : {
        "x" : 3627,
        "y" : 1128
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3620,
        "y" : 1132
      },
      "b" : {
        "x" : 3627,
        "y" : 1128
      },
      "c" : {
        "x" : 3620,
        "y" : 1124
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3620,
        "y" : 1124
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3592,
        "y" : 1123
      },
      "b" : {
        "x" : 3604,
        "y" : 1135
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3598,
        "y" : 1129
      }
    },
    "inputs" : [ {
      "id" : 2615
    } ],
    "outputs" : [ {
      "id" : 2616
    } ],
    "activators" : [ {
      "id" : 2656,
      "points" : [ {
        "x" : 3554,
        "y" : 1078
      }, {
        "x" : 3577,
        "y" : 1082
      } ]
    } ]
  }, {
    "id" : 2523,
    "reactomeId" : 934604,
    "displayName" : "Phosphorylated SPRY2 is ubiquitinated by CBL",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6224,
      "y" : 1775
    },
    "minX" : 6218,
    "maxX" : 6230,
    "minY" : 1737,
    "maxY" : 1838,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 6218,
        "y" : 1737
      },
      "to" : {
        "x" : 6224,
        "y" : 1775
      }
    }, {
      "from" : {
        "x" : 6224,
        "y" : 1775
      },
      "to" : {
        "x" : 6226,
        "y" : 1838
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 6222,
        "y" : 1831
      },
      "b" : {
        "x" : 6226,
        "y" : 1838
      },
      "c" : {
        "x" : 6230,
        "y" : 1831
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 6230,
        "y" : 1831
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 6218,
        "y" : 1769
      },
      "b" : {
        "x" : 6230,
        "y" : 1781
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 6224,
        "y" : 1775
      }
    },
    "inputs" : [ {
      "id" : 2518,
      "points" : [ {
        "x" : 6218,
        "y" : 1694
      } ]
    }, {
      "id" : 2561,
      "points" : [ {
        "x" : 6115,
        "y" : 1733
      } ]
    } ],
    "outputs" : [ {
      "id" : 2524
    } ],
    "catalysts" : [ {
      "id" : 2518,
      "points" : [ {
        "x" : 6244,
        "y" : 1694
      }, {
        "x" : 6311,
        "y" : 1738
      } ]
    } ]
  }, {
    "id" : 13659,
    "reactomeId" : 5654514,
    "displayName" : "KAL1 binds FGFR1c",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 28,
      "y" : 1152
    },
    "minX" : 17,
    "maxX" : 198,
    "minY" : 928,
    "maxY" : 1230,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 17,
        "y" : 928
      },
      "to" : {
        "x" : 28,
        "y" : 1152
      }
    }, {
      "from" : {
        "x" : 28,
        "y" : 1152
      },
      "to" : {
        "x" : 198,
        "y" : 1230
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 190,
        "y" : 1231
      },
      "b" : {
        "x" : 198,
        "y" : 1230
      },
      "c" : {
        "x" : 193,
        "y" : 1223
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 193,
        "y" : 1223
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 28,
        "y" : 1152
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 28,
        "y" : 1152
      }
    },
    "inputs" : [ {
      "id" : 13614,
      "points" : [ {
        "x" : 30,
        "y" : 881
      } ]
    }, {
      "id" : 2402,
      "points" : [ {
        "x" : 270,
        "y" : 888
      } ]
    } ],
    "outputs" : [ {
      "id" : 13593
    } ]
  }, {
    "id" : 3037,
    "reactomeId" : 1549564,
    "displayName" : "PPTN11 dephosphorylates SPRY2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6062,
      "y" : 1360
    },
    "minX" : 6052,
    "maxX" : 6165,
    "minY" : 1264,
    "maxY" : 1399,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 6165,
        "y" : 1399
      },
      "to" : {
        "x" : 6062,
        "y" : 1360
      }
    }, {
      "from" : {
        "x" : 6062,
        "y" : 1360
      },
      "to" : {
        "x" : 6052,
        "y" : 1264
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 6056,
        "y" : 1354
      },
      "b" : {
        "x" : 6068,
        "y" : 1366
      },
      "s" : "",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 6062,
        "y" : 1360
      }
    },
    "inputs" : [ {
      "id" : 2578
    } ],
    "outputs" : [ {
      "id" : 1523,
      "points" : [ {
        "x" : 6105,
        "y" : 1303
      } ]
    }, {
      "id" : 2576,
      "points" : [ {
        "x" : 6175,
        "y" : 1231
      } ]
    } ],
    "catalysts" : [ {
      "id" : 1106,
      "points" : [ {
        "x" : 3464,
        "y" : 645
      }, {
        "x" : 5359,
        "y" : 1375
      } ]
    } ]
  }, {
    "id" : 8863,
    "reactomeId" : 5654392,
    "displayName" : "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3326,
      "y" : 816
    },
    "minX" : 3295,
    "maxX" : 3371,
    "minY" : 810,
    "maxY" : 822,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3295,
        "y" : 815
      },
      "to" : {
        "x" : 3326,
        "y" : 816
      }
    }, {
      "from" : {
        "x" : 3326,
        "y" : 816
      },
      "to" : {
        "x" : 3371,
        "y" : 817
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3320,
        "y" : 810
      },
      "b" : {
        "x" : 3332,
        "y" : 822
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3326,
        "y" : 816
      }
    },
    "inputs" : [ {
      "id" : 2319,
      "points" : [ {
        "x" : 3206,
        "y" : 794
      } ]
    }, {
      "id" : 2326,
      "points" : [ {
        "x" : 3201,
        "y" : 870
      } ]
    } ],
    "outputs" : [ {
      "id" : 2325,
      "points" : [ {
        "x" : 3412,
        "y" : 849
      } ]
    }, {
      "id" : 2320,
      "points" : [ {
        "x" : 3479,
        "y" : 792
      } ]
    } ],
    "catalysts" : [ {
      "id" : 8862,
      "points" : [ {
        "x" : 3259,
        "y" : 502
      }, {
        "x" : 3370,
        "y" : 534
      } ]
    } ]
  }, {
    "id" : 8864,
    "reactomeId" : 5654584,
    "displayName" : "Activated FGFR1:p-FRS bind to PPTN11",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3426,
      "y" : 390
    },
    "minX" : 3402,
    "maxX" : 3480,
    "minY" : 385,
    "maxY" : 395,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3402,
        "y" : 389
      },
      "to" : {
        "x" : 3426,
        "y" : 390
      }
    }, {
      "from" : {
        "x" : 3426,
        "y" : 390
      },
      "to" : {
        "x" : 3480,
        "y" : 394
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3473,
        "y" : 397
      },
      "b" : {
        "x" : 3480,
        "y" : 394
      },
      "c" : {
        "x" : 3473,
        "y" : 389
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3473,
        "y" : 389
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3426,
        "y" : 390
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3426,
        "y" : 390
      }
    },
    "inputs" : [ {
      "id" : 1106,
      "points" : [ {
        "x" : 3428,
        "y" : 612
      } ]
    }, {
      "id" : 8859,
      "points" : [ {
        "x" : 3000,
        "y" : 420
      }, {
        "x" : 3076,
        "y" : 382
      } ]
    } ],
    "outputs" : [ {
      "id" : 8865
    } ]
  }, {
    "id" : 480,
    "reactomeId" : 190256,
    "displayName" : "FGFR1c binds to FGF",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 362,
      "y" : 1099
    },
    "minX" : 357,
    "maxX" : 367,
    "minY" : 1067,
    "maxY" : 1258,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 360,
        "y" : 1067
      },
      "to" : {
        "x" : 362,
        "y" : 1099
      }
    }, {
      "from" : {
        "x" : 362,
        "y" : 1099
      },
      "to" : {
        "x" : 360,
        "y" : 1258
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 356,
        "y" : 1251
      },
      "b" : {
        "x" : 360,
        "y" : 1258
      },
      "c" : {
        "x" : 364,
        "y" : 1251
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 364,
        "y" : 1251
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 362,
        "y" : 1099
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 362,
        "y" : 1099
      }
    },
    "inputs" : [ {
      "id" : 481,
      "points" : [ {
        "x" : 192,
        "y" : 967
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 2402,
      "points" : [ {
        "x" : 336,
        "y" : 902
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 4509,
      "points" : [ {
        "x" : 257,
        "y" : 1056
      } ]
    } ],
    "outputs" : [ {
      "id" : 483
    } ],
    "inhibitors" : [ {
      "id" : 13593,
      "points" : [ {
        "x" : 256,
        "y" : 1230
      } ]
    } ],
    "activators" : [ {
      "id" : 4509,
      "points" : [ {
        "x" : 257,
        "y" : 1066
      }, {
        "x" : 296,
        "y" : 1079
      } ]
    }, {
      "id" : 13594,
      "points" : [ {
        "x" : 159,
        "y" : 1106
      } ]
    }, {
      "id" : 13874,
      "points" : [ {
        "x" : 802,
        "y" : 491
      }, {
        "x" : 799,
        "y" : 888
      }, {
        "x" : 485,
        "y" : 960
      } ]
    } ]
  }, {
    "id" : 2593,
    "reactomeId" : 1295632,
    "displayName" : "PPA2A dephosphorylates SPRY2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 5869,
      "y" : 775
    },
    "minX" : 5863,
    "maxX" : 5875,
    "minY" : 706,
    "maxY" : 810,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 5868,
        "y" : 706
      },
      "to" : {
        "x" : 5869,
        "y" : 775
      }
    }, {
      "from" : {
        "x" : 5869,
        "y" : 775
      },
      "to" : {
        "x" : 5872,
        "y" : 810
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 5863,
        "y" : 769
      },
      "b" : {
        "x" : 5875,
        "y" : 781
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 5869,
        "y" : 775
      }
    },
    "inputs" : [ {
      "id" : 2594
    } ],
    "outputs" : [ {
      "id" : 2595,
      "points" : [ {
        "x" : 5918,
        "y" : 825
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 2570,
      "points" : [ {
        "x" : 5909,
        "y" : 856
      } ]
    } ],
    "catalysts" : [ {
      "id" : 2594,
      "points" : [ {
        "x" : 5854,
        "y" : 706
      }, {
        "x" : 5828,
        "y" : 741
      } ]
    } ]
  }, {
    "id" : 8929,
    "reactomeId" : 5654560,
    "displayName" : "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2762,
      "y" : 543
    },
    "minX" : 2719,
    "maxX" : 2796,
    "minY" : 537,
    "maxY" : 549,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2719,
        "y" : 543
      },
      "to" : {
        "x" : 2762,
        "y" : 543
      }
    }, {
      "from" : {
        "x" : 2762,
        "y" : 543
      },
      "to" : {
        "x" : 2796,
        "y" : 543
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2756,
        "y" : 537
      },
      "b" : {
        "x" : 2768,
        "y" : 549
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2762,
        "y" : 543
      }
    },
    "inputs" : [ {
      "id" : 8838,
      "points" : [ {
        "x" : 2488,
        "y" : 368
      } ]
    }, {
      "id" : 8930,
      "points" : [ {
        "x" : 2695,
        "y" : 608
      } ],
      "stoichiometry" : 8
    } ],
    "outputs" : [ {
      "id" : 8931,
      "points" : [ {
        "x" : 2829,
        "y" : 552
      } ]
    }, {
      "id" : 8932,
      "points" : [ {
        "x" : 2821,
        "y" : 621
      } ],
      "stoichiometry" : 8
    } ],
    "catalysts" : [ {
      "id" : 2656,
      "points" : [ {
        "x" : 3415,
        "y" : 1069
      }, {
        "x" : 2757,
        "y" : 1066
      } ]
    } ]
  }, {
    "id" : 8866,
    "reactomeId" : 5654587,
    "displayName" : "Activated FGFR1:p-FRS phosphorylates PPTN11",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3662,
      "y" : 396
    },
    "minX" : 3637,
    "maxX" : 3690,
    "minY" : 390,
    "maxY" : 402,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3637,
        "y" : 395
      },
      "to" : {
        "x" : 3662,
        "y" : 396
      }
    }, {
      "from" : {
        "x" : 3662,
        "y" : 396
      },
      "to" : {
        "x" : 3690,
        "y" : 396
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3656,
        "y" : 390
      },
      "b" : {
        "x" : 3668,
        "y" : 402
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3662,
        "y" : 396
      }
    },
    "inputs" : [ {
      "id" : 13616,
      "points" : [ {
        "x" : 3625,
        "y" : 452
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 8865,
      "points" : [ {
        "x" : 3613,
        "y" : 396
      } ]
    } ],
    "outputs" : [ {
      "id" : 8868,
      "points" : [ {
        "x" : 3710,
        "y" : 427
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 8869,
      "points" : [ {
        "x" : 3754,
        "y" : 396
      } ]
    } ],
    "catalysts" : [ {
      "id" : 8865,
      "points" : [ {
        "x" : 3579,
        "y" : 371
      }, {
        "x" : 3632,
        "y" : 334
      } ]
    } ]
  }, {
    "id" : 2276,
    "reactomeId" : 177931,
    "displayName" : "Binding of PIK3 regulatory alpha subunit to GRB2:GAB1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 4047,
      "y" : 684
    },
    "minX" : 4041,
    "maxX" : 4054,
    "minY" : 648,
    "maxY" : 717,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 4054,
        "y" : 717
      },
      "to" : {
        "x" : 4047,
        "y" : 684
      }
    }, {
      "from" : {
        "x" : 4047,
        "y" : 684
      },
      "to" : {
        "x" : 4041,
        "y" : 648
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4046,
        "y" : 654
      },
      "b" : {
        "x" : 4041,
        "y" : 648
      },
      "c" : {
        "x" : 4038,
        "y" : 655
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 4038,
        "y" : 655
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 4047,
        "y" : 684
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 4047,
        "y" : 684
      }
    },
    "inputs" : [ {
      "id" : 2199,
      "points" : [ {
        "x" : 4017,
        "y" : 734
      } ]
    }, {
      "id" : 2277,
      "points" : [ {
        "x" : 4106,
        "y" : 739
      } ]
    } ],
    "outputs" : [ {
      "id" : 2278
    } ]
  }, {
    "id" : 8933,
    "reactomeId" : 5654673,
    "displayName" : "p-CBL:GRB2 binds p-FRS2:activated FGFR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 5144,
      "y" : 518
    },
    "minX" : 5109,
    "maxX" : 5172,
    "minY" : 513,
    "maxY" : 523,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 5109,
        "y" : 518
      },
      "to" : {
        "x" : 5144,
        "y" : 518
      }
    }, {
      "from" : {
        "x" : 5144,
        "y" : 518
      },
      "to" : {
        "x" : 5172,
        "y" : 514
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 5166,
        "y" : 519
      },
      "b" : {
        "x" : 5172,
        "y" : 514
      },
      "c" : {
        "x" : 5165,
        "y" : 511
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 5165,
        "y" : 511
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 5144,
        "y" : 518
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 5144,
        "y" : 518
      }
    },
    "inputs" : [ {
      "id" : 2479,
      "points" : [ {
        "x" : 5005,
        "y" : 605
      } ]
    }, {
      "id" : 8917,
      "points" : [ {
        "x" : 3923,
        "y" : 457
      }, {
        "x" : 4004,
        "y" : 294
      }, {
        "x" : 4967,
        "y" : 297
      } ]
    } ],
    "outputs" : [ {
      "id" : 8934
    } ]
  }, {
    "id" : 13669,
    "reactomeId" : 5656064,
    "displayName" : "Activated FGFR1 binds FLRT1,2,3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2177,
      "y" : 549
    },
    "minX" : 2161,
    "maxX" : 2212,
    "minY" : 543,
    "maxY" : 561,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2161,
        "y" : 543
      },
      "to" : {
        "x" : 2177,
        "y" : 549
      }
    }, {
      "from" : {
        "x" : 2177,
        "y" : 549
      },
      "to" : {
        "x" : 2212,
        "y" : 561
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2204,
        "y" : 563
      },
      "b" : {
        "x" : 2212,
        "y" : 561
      },
      "c" : {
        "x" : 2207,
        "y" : 555
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2207,
        "y" : 555
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2177,
        "y" : 549
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2177,
        "y" : 549
      }
    },
    "inputs" : [ {
      "id" : 8833,
      "points" : [ {
        "x" : 2173,
        "y" : 431
      } ]
    }, {
      "id" : 13618,
      "points" : [ {
        "x" : 2119,
        "y" : 568
      } ]
    } ],
    "outputs" : [ {
      "id" : 13624
    } ]
  }, {
    "id" : 487,
    "reactomeId" : 190429,
    "displayName" : "Autocatalytic phosphorylation of FGFR1c",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 359,
      "y" : 1340
    },
    "minX" : 353,
    "maxX" : 365,
    "minY" : 1323,
    "maxY" : 1355,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 358,
        "y" : 1323
      },
      "to" : {
        "x" : 359,
        "y" : 1340
      }
    }, {
      "from" : {
        "x" : 359,
        "y" : 1340
      },
      "to" : {
        "x" : 358,
        "y" : 1355
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 353,
        "y" : 1334
      },
      "b" : {
        "x" : 365,
        "y" : 1346
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 359,
        "y" : 1340
      }
    },
    "inputs" : [ {
      "id" : 2449,
      "points" : [ {
        "x" : 403,
        "y" : 1320
      } ],
      "stoichiometry" : 16
    }, {
      "id" : 483,
      "points" : [ {
        "x" : 359,
        "y" : 1300
      } ]
    } ],
    "outputs" : [ {
      "id" : 2450,
      "points" : [ {
        "x" : 391,
        "y" : 1357
      } ],
      "stoichiometry" : 16
    }, {
      "id" : 489,
      "points" : [ {
        "x" : 358,
        "y" : 1376
      } ]
    } ],
    "catalysts" : [ {
      "id" : 483,
      "points" : [ {
        "x" : 333,
        "y" : 1300
      }, {
        "x" : 302,
        "y" : 1319
      } ]
    } ]
  }, {
    "id" : 2536,
    "reactomeId" : 1295621,
    "displayName" : "CBL dissociates from ubiquitinated p-SPRY2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6160,
      "y" : 1934
    },
    "minX" : 6144,
    "maxX" : 6206,
    "minY" : 1888,
    "maxY" : 1949,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 6206,
        "y" : 1888
      },
      "to" : {
        "x" : 6160,
        "y" : 1934
      }
    }, {
      "from" : {
        "x" : 6160,
        "y" : 1934
      },
      "to" : {
        "x" : 6144,
        "y" : 1949
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 6160,
        "y" : 1934
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 6160,
        "y" : 1934
      }
    },
    "inputs" : [ {
      "id" : 2524
    } ],
    "outputs" : [ {
      "id" : 2522,
      "points" : [ {
        "x" : 6104,
        "y" : 1483
      }, {
        "x" : 5961,
        "y" : 1529
      }, {
        "x" : 5965,
        "y" : 1948
      } ]
    }, {
      "id" : 2762,
      "points" : [ {
        "x" : 6107,
        "y" : 2020
      } ]
    } ]
  }, {
    "id" : 2601,
    "reactomeId" : 934559,
    "displayName" : "SPRY2 is phosphorylated by phosphorylated MNK1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6213,
      "y" : 996
    },
    "minX" : 6207,
    "maxX" : 6219,
    "minY" : 960,
    "maxY" : 1035,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 6216,
        "y" : 960
      },
      "to" : {
        "x" : 6213,
        "y" : 996
      }
    }, {
      "from" : {
        "x" : 6213,
        "y" : 996
      },
      "to" : {
        "x" : 6219,
        "y" : 1035
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 6207,
        "y" : 990
      },
      "b" : {
        "x" : 6219,
        "y" : 1002
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 6213,
        "y" : 996
      }
    },
    "inputs" : [ {
      "id" : 2602,
      "points" : [ {
        "x" : 6254,
        "y" : 928
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 2568,
      "points" : [ {
        "x" : 6223,
        "y" : 873
      } ]
    } ],
    "outputs" : [ {
      "id" : 2603,
      "points" : [ {
        "x" : 6261,
        "y" : 1041
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 2604,
      "points" : [ {
        "x" : 6224,
        "y" : 1104
      } ]
    } ],
    "catalysts" : [ {
      "id" : 2605,
      "points" : [ {
        "x" : 6049,
        "y" : 993
      } ]
    } ]
  }, {
    "id" : 494,
    "reactomeId" : 190268,
    "displayName" : "FGFR1c binds to Klotho-bound FGF23",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 363,
      "y" : 1629
    },
    "minX" : 358,
    "maxX" : 368,
    "minY" : 1587,
    "maxY" : 1658,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 359,
        "y" : 1587
      },
      "to" : {
        "x" : 363,
        "y" : 1629
      }
    }, {
      "from" : {
        "x" : 363,
        "y" : 1629
      },
      "to" : {
        "x" : 363,
        "y" : 1658
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 359,
        "y" : 1651
      },
      "b" : {
        "x" : 363,
        "y" : 1658
      },
      "c" : {
        "x" : 367,
        "y" : 1651
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 367,
        "y" : 1651
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 363,
        "y" : 1629
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 363,
        "y" : 1629
      }
    },
    "inputs" : [ {
      "id" : 495,
      "points" : [ {
        "x" : 242,
        "y" : 1553
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 2402,
      "points" : [ {
        "x" : 343,
        "y" : 902
      }, {
        "x" : 505,
        "y" : 1246
      }, {
        "x" : 509,
        "y" : 1502
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 4505,
      "points" : [ {
        "x" : 220,
        "y" : 1611
      } ]
    } ],
    "outputs" : [ {
      "id" : 496
    } ],
    "activators" : [ {
      "id" : 4505,
      "points" : [ {
        "x" : 220,
        "y" : 1622
      } ]
    } ]
  }, {
    "id" : 13615,
    "reactomeId" : 5654515,
    "displayName" : "KAL1 binds HS",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 70,
      "y" : 1043
    },
    "minX" : 63,
    "maxX" : 102,
    "minY" : 998,
    "maxY" : 1086,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 63,
        "y" : 998
      },
      "to" : {
        "x" : 70,
        "y" : 1043
      }
    }, {
      "from" : {
        "x" : 70,
        "y" : 1043
      },
      "to" : {
        "x" : 102,
        "y" : 1086
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 95,
        "y" : 1083
      },
      "b" : {
        "x" : 102,
        "y" : 1086
      },
      "c" : {
        "x" : 101,
        "y" : 1078
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 101,
        "y" : 1078
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 70,
        "y" : 1043
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 70,
        "y" : 1043
      }
    },
    "inputs" : [ {
      "id" : 13614,
      "points" : [ {
        "x" : 36,
        "y" : 881
      } ]
    }, {
      "id" : 4509,
      "points" : [ {
        "x" : 151,
        "y" : 1030
      } ]
    } ],
    "outputs" : [ {
      "id" : 13594
    } ]
  }, {
    "id" : 8880,
    "reactomeId" : 5654167,
    "displayName" : "Activated FGFR1 binds PLCG1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2020,
      "y" : 305
    },
    "minX" : 1996,
    "maxX" : 2043,
    "minY" : 268,
    "maxY" : 343,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2043,
        "y" : 343
      },
      "to" : {
        "x" : 2020,
        "y" : 305
      }
    }, {
      "from" : {
        "x" : 2020,
        "y" : 305
      },
      "to" : {
        "x" : 1996,
        "y" : 268
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2003,
        "y" : 272
      },
      "b" : {
        "x" : 1996,
        "y" : 268
      },
      "c" : {
        "x" : 1996,
        "y" : 276
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1996,
        "y" : 276
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2020,
        "y" : 305
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2020,
        "y" : 305
      }
    },
    "inputs" : [ {
      "id" : 1534,
      "points" : [ {
        "x" : 1991,
        "y" : 357
      } ]
    }, {
      "id" : 8833,
      "points" : [ {
        "x" : 2154,
        "y" : 397
      } ]
    }, {
      "id" : 3009,
      "points" : [ {
        "x" : 2062,
        "y" : 332
      } ]
    } ],
    "outputs" : [ {
      "id" : 8881
    } ]
  }, {
    "id" : 8944,
    "reactomeId" : 5654672,
    "displayName" : "CBL ubiquitinates FRS2 and FGFR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 5414,
      "y" : 510
    },
    "minX" : 5381,
    "maxX" : 5455,
    "minY" : 504,
    "maxY" : 516,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 5381,
        "y" : 509
      },
      "to" : {
        "x" : 5414,
        "y" : 510
      }
    }, {
      "from" : {
        "x" : 5414,
        "y" : 510
      },
      "to" : {
        "x" : 5455,
        "y" : 510
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 5448,
        "y" : 514
      },
      "b" : {
        "x" : 5455,
        "y" : 510
      },
      "c" : {
        "x" : 5448,
        "y" : 506
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 5448,
        "y" : 506
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 5408,
        "y" : 504
      },
      "b" : {
        "x" : 5420,
        "y" : 516
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 5414,
        "y" : 510
      }
    },
    "inputs" : [ {
      "id" : 8934,
      "points" : [ {
        "x" : 5344,
        "y" : 507
      } ]
    }, {
      "id" : 2395,
      "points" : [ {
        "x" : 5359,
        "y" : 615
      } ]
    } ],
    "outputs" : [ {
      "id" : 8945
    } ],
    "catalysts" : [ {
      "id" : 8934,
      "points" : [ {
        "x" : 5344,
        "y" : 480
      }, {
        "x" : 5384,
        "y" : 468
      } ]
    } ]
  }, {
    "id" : 8882,
    "reactomeId" : 5654149,
    "displayName" : "Activated FGFR1 phosphorylates PLCG1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1845,
      "y" : 243
    },
    "minX" : 1807,
    "maxX" : 1870,
    "minY" : 237,
    "maxY" : 249,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1870,
        "y" : 243
      },
      "to" : {
        "x" : 1845,
        "y" : 243
      }
    }, {
      "from" : {
        "x" : 1845,
        "y" : 243
      },
      "to" : {
        "x" : 1807,
        "y" : 245
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1839,
        "y" : 237
      },
      "b" : {
        "x" : 1851,
        "y" : 249
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1845,
        "y" : 243
      }
    },
    "inputs" : [ {
      "id" : 8881,
      "points" : [ {
        "x" : 1916,
        "y" : 241
      } ]
    }, {
      "id" : 8883,
      "points" : [ {
        "x" : 1888,
        "y" : 219
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 8884,
      "points" : [ {
        "x" : 1773,
        "y" : 246
      } ]
    }, {
      "id" : 8885,
      "points" : [ {
        "x" : 1793,
        "y" : 212
      } ],
      "stoichiometry" : 4
    } ],
    "catalysts" : [ {
      "id" : 8881,
      "points" : [ {
        "x" : 1921,
        "y" : 268
      }, {
        "x" : 1886,
        "y" : 279
      } ]
    } ]
  }, {
    "id" : 8886,
    "reactomeId" : 5654165,
    "displayName" : "p-4Y-PLCG1 dissociates from activated FGFR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1574,
      "y" : 243
    },
    "minX" : 1569,
    "maxX" : 1655,
    "minY" : 141,
    "maxY" : 248,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 1655,
        "y" : 246
      },
      "to" : {
        "x" : 1574,
        "y" : 243
      }
    }, {
      "from" : {
        "x" : 1574,
        "y" : 243
      },
      "to" : {
        "x" : 1576,
        "y" : 141
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1574,
        "y" : 243
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 1574,
        "y" : 243
      }
    },
    "inputs" : [ {
      "id" : 8884
    } ],
    "outputs" : [ {
      "id" : 8833,
      "points" : [ {
        "x" : 2175,
        "y" : 397
      }, {
        "x" : 2181,
        "y" : 149
      } ]
    }, {
      "id" : 1545,
      "points" : [ {
        "x" : 1529,
        "y" : 165
      } ]
    } ]
  }, {
    "id" : 822,
    "reactomeId" : 191062,
    "displayName" : "Autocatalytic phosphorylation of Klotho-bound FGFR1c",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 368,
      "y" : 1755
    },
    "minX" : 362,
    "maxX" : 374,
    "minY" : 1736,
    "maxY" : 1774,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 367,
        "y" : 1736
      },
      "to" : {
        "x" : 368,
        "y" : 1755
      }
    }, {
      "from" : {
        "x" : 368,
        "y" : 1755
      },
      "to" : {
        "x" : 370,
        "y" : 1774
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 362,
        "y" : 1749
      },
      "b" : {
        "x" : 374,
        "y" : 1761
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 368,
        "y" : 1755
      }
    },
    "inputs" : [ {
      "id" : 2452,
      "points" : [ {
        "x" : 408,
        "y" : 1737
      } ],
      "stoichiometry" : 16
    }, {
      "id" : 496,
      "points" : [ {
        "x" : 365,
        "y" : 1716
      } ]
    } ],
    "outputs" : [ {
      "id" : 2453,
      "points" : [ {
        "x" : 411,
        "y" : 1777
      } ],
      "stoichiometry" : 16
    }, {
      "id" : 824,
      "points" : [ {
        "x" : 373,
        "y" : 1793
      } ]
    } ],
    "catalysts" : [ {
      "id" : 496,
      "points" : [ {
        "x" : 348,
        "y" : 1716
      }, {
        "x" : 330,
        "y" : 1745
      } ]
    } ]
  }, {
    "id" : 2550,
    "reactomeId" : 1295609,
    "displayName" : "SRC phosphorylates SPRY2 on Y55 and Y227",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 5913,
      "y" : 1141
    },
    "minX" : 5907,
    "maxX" : 6072,
    "minY" : 941,
    "maxY" : 1195,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 5911,
        "y" : 941
      },
      "to" : {
        "x" : 5913,
        "y" : 1141
      }
    }, {
      "from" : {
        "x" : 5913,
        "y" : 1141
      },
      "to" : {
        "x" : 6072,
        "y" : 1195
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 5907,
        "y" : 1135
      },
      "b" : {
        "x" : 5919,
        "y" : 1147
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 5913,
        "y" : 1141
      }
    },
    "inputs" : [ {
      "id" : 2568,
      "points" : [ {
        "x" : 6173,
        "y" : 864
      } ]
    }, {
      "id" : 2572,
      "points" : [ {
        "x" : 5856,
        "y" : 924
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 2575,
      "points" : [ {
        "x" : 6028,
        "y" : 1211
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 2576,
      "points" : [ {
        "x" : 6156,
        "y" : 1203
      } ]
    } ],
    "catalysts" : [ {
      "id" : 2554,
      "points" : [ {
        "x" : 5868,
        "y" : 1080
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 2604,
      "points" : [ {
        "x" : 6166,
        "y" : 1132
      } ]
    } ]
  }, {
    "id" : 8887,
    "reactomeId" : 5654573,
    "displayName" : "Activated FGFR1 binds SHC1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2360,
      "y" : 491
    },
    "minX" : 2326,
    "maxX" : 2379,
    "minY" : 478,
    "maxY" : 530,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2326,
        "y" : 478
      },
      "to" : {
        "x" : 2360,
        "y" : 491
      }
    }, {
      "from" : {
        "x" : 2360,
        "y" : 491
      },
      "to" : {
        "x" : 2379,
        "y" : 530
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2372,
        "y" : 526
      },
      "b" : {
        "x" : 2379,
        "y" : 530
      },
      "c" : {
        "x" : 2380,
        "y" : 522
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2380,
        "y" : 522
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2360,
        "y" : 491
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2360,
        "y" : 491
      }
    },
    "inputs" : [ {
      "id" : 2338,
      "points" : [ {
        "x" : 2326,
        "y" : 632
      } ]
    }, {
      "id" : 8833,
      "points" : [ {
        "x" : 2200,
        "y" : 431
      } ]
    } ],
    "outputs" : [ {
      "id" : 8888
    } ]
  }, {
    "id" : 8889,
    "reactomeId" : 5654582,
    "displayName" : "Activated FGFR1 phosphorylates SHC1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2494,
      "y" : 558
    },
    "minX" : 2469,
    "maxX" : 2517,
    "minY" : 552,
    "maxY" : 564,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2469,
        "y" : 558
      },
      "to" : {
        "x" : 2494,
        "y" : 558
      }
    }, {
      "from" : {
        "x" : 2494,
        "y" : 558
      },
      "to" : {
        "x" : 2517,
        "y" : 558
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2488,
        "y" : 552
      },
      "b" : {
        "x" : 2500,
        "y" : 564
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2494,
        "y" : 558
      }
    },
    "inputs" : [ {
      "id" : 8888,
      "points" : [ {
        "x" : 2448,
        "y" : 557
      } ]
    }, {
      "id" : 8890,
      "points" : [ {
        "x" : 2449,
        "y" : 610
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 8891,
      "points" : [ {
        "x" : 2545,
        "y" : 556
      } ]
    }, {
      "id" : 8892,
      "points" : [ {
        "x" : 2545,
        "y" : 608
      } ],
      "stoichiometry" : 3
    } ],
    "catalysts" : [ {
      "id" : 8888,
      "points" : [ {
        "x" : 2448,
        "y" : 534
      }, {
        "x" : 2473,
        "y" : 522
      } ]
    } ]
  }, {
    "id" : 13113,
    "reactomeId" : 5654510,
    "displayName" : "FGFRL1 binds SPRED1/2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 838,
      "y" : 2068
    },
    "minX" : 791,
    "maxX" : 960,
    "minY" : 1969,
    "maxY" : 2082,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 791,
        "y" : 1969
      },
      "to" : {
        "x" : 838,
        "y" : 2068
      }
    }, {
      "from" : {
        "x" : 838,
        "y" : 2068
      },
      "to" : {
        "x" : 960,
        "y" : 2082
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 953,
        "y" : 2085
      },
      "b" : {
        "x" : 960,
        "y" : 2082
      },
      "c" : {
        "x" : 954,
        "y" : 2077
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 954,
        "y" : 2077
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 838,
        "y" : 2068
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 838,
        "y" : 2068
      }
    },
    "inputs" : [ {
      "id" : 13060,
      "points" : [ {
        "x" : 407,
        "y" : 1924
      } ]
    }, {
      "id" : 13114,
      "points" : [ {
        "x" : 1267,
        "y" : 2031
      } ]
    } ],
    "outputs" : [ {
      "id" : 13115
    } ]
  }, {
    "id" : 2555,
    "reactomeId" : 1295599,
    "displayName" : "SPRY2 translocates to the plasma membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 6009,
      "y" : 876
    },
    "minX" : 5980,
    "maxX" : 6173,
    "minY" : 855,
    "maxY" : 882,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 5980,
        "y" : 876
      },
      "to" : {
        "x" : 6009,
        "y" : 876
      }
    }, {
      "from" : {
        "x" : 6009,
        "y" : 876
      },
      "to" : {
        "x" : 6173,
        "y" : 855
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 6167,
        "y" : 860
      },
      "b" : {
        "x" : 6173,
        "y" : 855
      },
      "c" : {
        "x" : 6166,
        "y" : 852
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 6166,
        "y" : 852
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 6003,
        "y" : 870
      },
      "b" : {
        "x" : 6015,
        "y" : 882
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 6009,
        "y" : 876
      }
    },
    "inputs" : [ {
      "id" : 2570
    } ],
    "outputs" : [ {
      "id" : 2568
    } ]
  }, {
    "id" : 2620,
    "reactomeId" : 1295604,
    "displayName" : "B-RAF dissociates from S110/S120 p-SPRY2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3753,
      "y" : 1124
    },
    "minX" : 3729,
    "maxX" : 3788,
    "minY" : 1119,
    "maxY" : 1129,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 3729,
        "y" : 1125
      },
      "to" : {
        "x" : 3753,
        "y" : 1124
      }
    }, {
      "from" : {
        "x" : 3753,
        "y" : 1124
      },
      "to" : {
        "x" : 3788,
        "y" : 1123
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 3753,
        "y" : 1124
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 3753,
        "y" : 1124
      }
    },
    "inputs" : [ {
      "id" : 2616
    } ],
    "outputs" : [ {
      "id" : 2621,
      "points" : [ {
        "x" : 3826,
        "y" : 1159
      } ]
    }, {
      "id" : 2622,
      "points" : [ {
        "x" : 3834,
        "y" : 1123
      } ]
    } ]
  }, {
    "id" : 8893,
    "reactomeId" : 5654597,
    "displayName" : "Activated FGFR1:p-SHC1 binds GRB2:SOS1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3122,
      "y" : 705
    },
    "minX" : 3066,
    "maxX" : 3192,
    "minY" : 582,
    "maxY" : 710,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3066,
        "y" : 706
      },
      "to" : {
        "x" : 3122,
        "y" : 705
      }
    }, {
      "from" : {
        "x" : 3122,
        "y" : 705
      },
      "to" : {
        "x" : 3192,
        "y" : 582
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3192,
        "y" : 590
      },
      "b" : {
        "x" : 3192,
        "y" : 582
      },
      "c" : {
        "x" : 3185,
        "y" : 586
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3185,
        "y" : 586
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3122,
        "y" : 705
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3122,
        "y" : 705
      }
    },
    "inputs" : [ {
      "id" : 8891,
      "points" : [ {
        "x" : 2624,
        "y" : 586
      }, {
        "x" : 2690,
        "y" : 698
      } ]
    }, {
      "id" : 1576,
      "points" : [ {
        "x" : 3028,
        "y" : 638
      } ]
    } ],
    "outputs" : [ {
      "id" : 8894
    } ]
  }, {
    "id" : 8895,
    "reactomeId" : 5654600,
    "displayName" : "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3308,
      "y" : 780
    },
    "minX" : 3288,
    "maxX" : 3388,
    "minY" : 774,
    "maxY" : 786,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3288,
        "y" : 781
      },
      "to" : {
        "x" : 3308,
        "y" : 780
      }
    }, {
      "from" : {
        "x" : 3308,
        "y" : 780
      },
      "to" : {
        "x" : 3388,
        "y" : 781
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3302,
        "y" : 774
      },
      "b" : {
        "x" : 3314,
        "y" : 786
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3308,
        "y" : 780
      }
    },
    "inputs" : [ {
      "id" : 2319,
      "points" : [ {
        "x" : 3206,
        "y" : 784
      } ]
    }, {
      "id" : 2326,
      "points" : [ {
        "x" : 3193,
        "y" : 870
      } ]
    } ],
    "outputs" : [ {
      "id" : 2320,
      "points" : [ {
        "x" : 3479,
        "y" : 782
      } ]
    }, {
      "id" : 2325,
      "points" : [ {
        "x" : 3422,
        "y" : 849
      } ]
    } ],
    "catalysts" : [ {
      "id" : 8894,
      "points" : [ {
        "x" : 3218,
        "y" : 582
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 918,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 3262,
      "y" : 1082
    },
    "minX" : 241,
    "maxX" : 6283,
    "minY" : 0,
    "maxY" : 2164,
    "prop" : {
      "x" : 241,
      "y" : 0,
      "width" : 6042,
      "height" : 2164
    },
    "textPosition" : {
      "x" : 1619,
      "y" : 781
    },
    "insets" : {
      "x" : 1229,
      "y" : 587,
      "width" : 4946,
      "height" : 1506
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 1576, 2199, 2276, 2277, 1534, 2325, 2338, 1106, 2278, 2320, 2319, 2326, 2395, 2479, 2285, 2656, 1545, 2125, 2127, 2271, 2291, 2668, 2671, 2570, 2572, 2575, 2615, 2616, 2621, 2622, 2620, 2651, 3005, 3007, 3009, 3139, 3140, 3143, 3147, 3160, 3166, 3175, 3176, 3178, 3180, 3184, 3185, 3190, 3193, 3195, 3207, 3208, 3210, 3217, 2554, 2561, 2579, 2594, 2605, 2550, 2593, 3037, 1523, 2518, 2522, 2524, 2576, 2595, 2602, 2603, 2555, 2568, 2578, 2604, 2762, 2521, 2523, 2536, 2601, 2514, 3651, 4439, 471, 476, 483, 489, 496, 824, 2401, 2402, 2449, 2450, 2452, 2453, 467, 474, 480, 487, 494, 822, 4444, 4475, 4781, 6280, 6415, 6447, 7040, 7041, 7460, 7461, 8456, 8463, 8464, 8468, 7440, 4509, 8834, 8835, 8836, 8832, 8833, 8838, 8839, 8840, 8850, 8851, 8852, 8853, 8854, 8856, 8858, 8859, 8860, 8861, 8862, 8863, 8864, 8865, 8866, 8868, 8869, 8880, 8881, 8882, 8883, 8884, 8885, 8886, 8887, 8888, 8889, 8890, 8891, 8892, 8893, 8894, 8895, 8896, 8897, 8907, 8908, 8909, 8910, 8911, 8912, 8915, 8916, 8917, 8918, 8919, 8929, 8930, 8931, 8932, 8933, 8934, 8944, 8945, 13064, 13060, 13067, 13113, 13115, 13114, 13593, 13618, 13624, 13655, 13656, 13669, 13670, 13671, 13675, 13677, 13678, 13679, 13680, 13681, 13682, 13683, 13685, 13676, 13686, 13687, 13688, 13697, 13703, 13704, 13716, 13719, 13720, 13721, 13722, 13723, 13732, 13733, 13736, 13737, 13738, 13739, 13750, 13751, 13752, 13753, 13762, 13763, 13764, 13765, 13616, 13833, 13834, 13835, 13837, 13840, 13841, 13842, 13844, 13846, 13847, 13848, 13849, 13850, 13851, 13852, 13853, 13854, 13861, 13862, 13863, 13864, 13865, 13866, 13867, 13868, 13869, 13871, 13870, 13873, 13872, 13874 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 8834,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1293,
      "y" : 1506
    },
    "minX" : 422,
    "maxX" : 2166,
    "minY" : 431,
    "maxY" : 1512,
    "segments" : [ {
      "from" : {
        "x" : 422,
        "y" : 1411
      },
      "to" : {
        "x" : 1293,
        "y" : 1506
      }
    }, {
      "from" : {
        "x" : 1293,
        "y" : 1506
      },
      "to" : {
        "x" : 2166,
        "y" : 431
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1287,
        "y" : 1500
      },
      "b" : {
        "x" : 1299,
        "y" : 1512
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1293,
        "y" : 1506
      }
    },
    "inputs" : [ {
      "id" : 489
    } ],
    "outputs" : [ {
      "id" : 8833
    } ]
  }, {
    "id" : 8835,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1402,
      "y" : 778
    },
    "minX" : 560,
    "maxX" : 2161,
    "minY" : 431,
    "maxY" : 868,
    "segments" : [ {
      "from" : {
        "x" : 560,
        "y" : 836
      },
      "to" : {
        "x" : 976,
        "y" : 868
      }
    }, {
      "from" : {
        "x" : 976,
        "y" : 868
      },
      "to" : {
        "x" : 1829,
        "y" : 689
      }
    }, {
      "from" : {
        "x" : 1829,
        "y" : 689
      },
      "to" : {
        "x" : 2161,
        "y" : 431
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1396,
        "y" : 772
      },
      "b" : {
        "x" : 1408,
        "y" : 784
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1402,
        "y" : 778
      }
    },
    "inputs" : [ {
      "id" : 476
    } ],
    "outputs" : [ {
      "id" : 8833
    } ]
  }, {
    "id" : 8836,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1295,
      "y" : 1559
    },
    "minX" : 435,
    "maxX" : 2166,
    "minY" : 431,
    "maxY" : 1806,
    "segments" : [ {
      "from" : {
        "x" : 435,
        "y" : 1806
      },
      "to" : {
        "x" : 1295,
        "y" : 1559
      }
    }, {
      "from" : {
        "x" : 1295,
        "y" : 1559
      },
      "to" : {
        "x" : 2166,
        "y" : 431
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1289,
        "y" : 1553
      },
      "b" : {
        "x" : 1301,
        "y" : 1565
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1295,
        "y" : 1559
      }
    },
    "inputs" : [ {
      "id" : 824
    } ],
    "outputs" : [ {
      "id" : 8833
    } ]
  }, {
    "id" : 13671,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 3502,
      "y" : 852
    },
    "minX" : 3489,
    "maxX" : 3516,
    "minY" : 807,
    "maxY" : 897,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 3516,
        "y" : 807
      },
      "to" : {
        "x" : 3489,
        "y" : 897
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3487,
        "y" : 889
      },
      "b" : {
        "x" : 3489,
        "y" : 897
      },
      "c" : {
        "x" : 3495,
        "y" : 892
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 3495,
        "y" : 892
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3496,
        "y" : 846
      },
      "b" : {
        "x" : 3508,
        "y" : 858
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3502,
        "y" : 852
      }
    },
    "inputs" : [ {
      "id" : 2320
    } ],
    "outputs" : [ {
      "id" : 13670
    } ]
  }, {
    "id" : 13833,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 3481,
      "y" : 1011
    },
    "minX" : 3475,
    "maxX" : 3487,
    "minY" : 973,
    "maxY" : 1050,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 3480,
        "y" : 973
      },
      "to" : {
        "x" : 3483,
        "y" : 1050
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3479,
        "y" : 1043
      },
      "b" : {
        "x" : 3483,
        "y" : 1050
      },
      "c" : {
        "x" : 3487,
        "y" : 1043
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 3487,
        "y" : 1043
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3475,
        "y" : 1005
      },
      "b" : {
        "x" : 3487,
        "y" : 1017
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3481,
        "y" : 1011
      }
    },
    "inputs" : [ {
      "id" : 13670
    } ],
    "outputs" : [ {
      "id" : 2656
    } ]
  }, {
    "id" : 13675,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 3759,
      "y" : 1031
    },
    "minX" : 3553,
    "maxX" : 3847,
    "minY" : 958,
    "maxY" : 1109,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 3553,
        "y" : 958
      },
      "to" : {
        "x" : 3759,
        "y" : 1031
      }
    }, {
      "from" : {
        "x" : 3759,
        "y" : 1031
      },
      "to" : {
        "x" : 3847,
        "y" : 1109
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3839,
        "y" : 1107
      },
      "b" : {
        "x" : 3847,
        "y" : 1109
      },
      "c" : {
        "x" : 3844,
        "y" : 1101
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 3844,
        "y" : 1101
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3753,
        "y" : 1025
      },
      "b" : {
        "x" : 3765,
        "y" : 1037
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3759,
        "y" : 1031
      }
    },
    "inputs" : [ {
      "id" : 13670
    } ],
    "outputs" : [ {
      "id" : 2622
    } ]
  }, {
    "id" : 8860,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2873,
      "y" : 351
    },
    "minX" : 2808,
    "maxX" : 2939,
    "minY" : 282,
    "maxY" : 420,
    "segments" : [ {
      "from" : {
        "x" : 2808,
        "y" : 282
      },
      "to" : {
        "x" : 2939,
        "y" : 420
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2867,
        "y" : 345
      },
      "b" : {
        "x" : 2879,
        "y" : 357
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2873,
        "y" : 351
      }
    },
    "inputs" : [ {
      "id" : 8856
    } ],
    "outputs" : [ {
      "id" : 8859
    } ]
  }, {
    "id" : 8861,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2878,
      "y" : 405
    },
    "minX" : 2842,
    "maxX" : 2914,
    "minY" : 390,
    "maxY" : 420,
    "segments" : [ {
      "from" : {
        "x" : 2842,
        "y" : 390
      },
      "to" : {
        "x" : 2914,
        "y" : 420
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2872,
        "y" : 399
      },
      "b" : {
        "x" : 2884,
        "y" : 411
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2878,
        "y" : 405
      }
    },
    "inputs" : [ {
      "id" : 8853
    } ],
    "outputs" : [ {
      "id" : 8859
    } ]
  }, {
    "id" : 2671,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 4877,
      "y" : 476
    },
    "minX" : 4869,
    "maxX" : 4886,
    "minY" : 458,
    "maxY" : 495,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 4869,
        "y" : 495
      },
      "to" : {
        "x" : 4886,
        "y" : 458
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 4887,
        "y" : 466
      },
      "b" : {
        "x" : 4886,
        "y" : 458
      },
      "c" : {
        "x" : 4879,
        "y" : 463
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 4879,
        "y" : 463
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 4871,
        "y" : 470
      },
      "b" : {
        "x" : 4883,
        "y" : 482
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 4877,
        "y" : 476
      }
    },
    "inputs" : [ {
      "id" : 2271
    } ],
    "outputs" : [ {
      "id" : 2668
    } ]
  }, {
    "id" : 3007,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1474,
      "y" : 137
    },
    "minX" : 1468,
    "maxX" : 1480,
    "minY" : 115,
    "maxY" : 160,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1475,
        "y" : 160
      },
      "to" : {
        "x" : 1474,
        "y" : 115
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1478,
        "y" : 122
      },
      "b" : {
        "x" : 1474,
        "y" : 115
      },
      "c" : {
        "x" : 1470,
        "y" : 122
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1470,
        "y" : 122
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1468,
        "y" : 131
      },
      "b" : {
        "x" : 1480,
        "y" : 143
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1474,
        "y" : 137
      }
    },
    "inputs" : [ {
      "id" : 1545
    } ],
    "outputs" : [ {
      "id" : 3005
    } ]
  } ],
  "shadows" : [ {
    "id" : 13875,
    "reactomeId" : 190242,
    "displayName" : "FGFR1 ligand binding and activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 433,
      "y" : 1120
    },
    "minX" : -10,
    "maxX" : 877,
    "minY" : 381,
    "maxY" : 1859,
    "prop" : {
      "x" : -10,
      "y" : 381,
      "width" : 887,
      "height" : 1468
    },
    "points" : [ {
      "x" : -10,
      "y" : 381
    }, {
      "x" : 877,
      "y" : 381
    }, {
      "x" : 877,
      "y" : 1859
    }, {
      "x" : -10,
      "y" : 1859
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 13876,
    "reactomeId" : 5654687,
    "displayName" : "Downstream signaling of activated FGFR1",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 3163,
      "y" : 521
    },
    "minX" : 1416,
    "maxX" : 4911,
    "minY" : 131,
    "maxY" : 912,
    "prop" : {
      "x" : 1416,
      "y" : 131,
      "width" : 3495,
      "height" : 188
    },
    "points" : [ {
      "x" : 1416,
      "y" : 131
    }, {
      "x" : 4911,
      "y" : 131
    }, {
      "x" : 4911,
      "y" : 912
    }, {
      "x" : 1416,
      "y" : 912
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 13877,
    "reactomeId" : 5654726,
    "displayName" : "Negative regulation of FGFR1 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 3155,
      "y" : 1194
    },
    "minX" : -10,
    "maxX" : 6320,
    "minY" : 319,
    "maxY" : 2069,
    "prop" : {
      "x" : 877,
      "y" : 912,
      "width" : 5443,
      "height" : 937
    },
    "points" : [ {
      "x" : -10,
      "y" : 319
    }, {
      "x" : 6320,
      "y" : 319
    }, {
      "x" : 6320,
      "y" : 2069
    }, {
      "x" : -10,
      "y" : 2069
    } ],
    "colour" : "#008000"
  }, {
    "id" : 13878,
    "reactomeId" : 5658623,
    "displayName" : "FGFRL1 modulation of FGFR1 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 756,
      "y" : 2005
    },
    "minX" : 107,
    "maxX" : 1406,
    "minY" : 1849,
    "maxY" : 2162,
    "prop" : {
      "x" : 107,
      "y" : 2069,
      "width" : 1299,
      "height" : 93
    },
    "points" : [ {
      "x" : 107,
      "y" : 1849
    }, {
      "x" : 1406,
      "y" : 1849
    }, {
      "x" : 1406,
      "y" : 2162
    }, {
      "x" : 107,
      "y" : 2162
    } ],
    "colour" : "#666666"
  } ],
  "minX" : 0,
  "maxX" : 6316,
  "minY" : 0,
  "maxY" : 2164,
  "disease" : true
}