{
  "dbId" : 5619052,
  "stableId" : "R-HSA-5619052",
  "displayName" : "Defective SLC9A9 causes autism 16 (AUTS16)",
  "forNormalDraw" : false,
  "nodes" : [ {
    "id" : 3,
    "reactomeId" : 114632,
    "displayName" : "Mg2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 438,
      "y" : 806
    },
    "isFadeOut" : true,
    "minX" : 418,
    "maxX" : 458,
    "minY" : 789,
    "maxY" : 824,
    "prop" : {
      "x" : 418,
      "y" : 789,
      "width" : 40,
      "height" : 35
    },
    "textPosition" : {
      "x" : 421,
      "y" : 789
    },
    "connectors" : [ {
      "edgeId" : 7,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 4,
    "reactomeId" : 29418,
    "displayName" : "Mn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 179,
      "y" : 673
    },
    "isFadeOut" : true,
    "minX" : 158,
    "maxX" : 201,
    "minY" : 654,
    "maxY" : 751,
    "prop" : {
      "x" : 158,
      "y" : 654,
      "width" : 43,
      "height" : 38
    },
    "textPosition" : {
      "x" : 162,
      "y" : 655
    },
    "connectors" : [ {
      "edgeId" : 15,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 179,
          "y" : 695
        },
        "to" : {
          "x" : 179,
          "y" : 751
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 5,
    "reactomeId" : 266099,
    "displayName" : "Mn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 180,
      "y" : 813
    },
    "isFadeOut" : true,
    "minX" : 158,
    "maxX" : 203,
    "minY" : 753,
    "maxY" : 833,
    "prop" : {
      "x" : 158,
      "y" : 793,
      "width" : 45,
      "height" : 40
    },
    "textPosition" : {
      "x" : 158,
      "y" : 802
    },
    "connectors" : [ {
      "edgeId" : 15,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 179,
          "y" : 790
        },
        "to" : {
          "x" : 179,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 175,
          "y" : 783
        },
        "b" : {
          "x" : 179,
          "y" : 790
        },
        "c" : {
          "x" : 183,
          "y" : 783
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 183,
          "y" : 783
        }
      }
    } ]
  }, {
    "id" : 262,
    "reactomeId" : 425969,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1497,
      "y" : 480
    },
    "isFadeOut" : true,
    "minX" : 1324,
    "maxX" : 1567,
    "minY" : 374,
    "maxY" : 577,
    "prop" : {
      "x" : 1482,
      "y" : 465,
      "width" : 31,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1484,
      "y" : 470
    },
    "connectors" : [ {
      "edgeId" : 354,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1508,
          "y" : 499
        },
        "to" : {
          "x" : 1567,
          "y" : 577
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 63,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1479,
          "y" : 477
        },
        "to" : {
          "x" : 1334,
          "y" : 456
        }
      }, {
        "from" : {
          "x" : 1334,
          "y" : 456
        },
        "to" : {
          "x" : 1324,
          "y" : 374
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1400,
            "y" : 460
          },
          "b" : {
            "x" : 1412,
            "y" : 472
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1406,
            "y" : 466
          }
        }
      }
    } ]
  }, {
    "id" : 265,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1216,
      "y" : 322
    },
    "isFadeOut" : true,
    "minX" : 1144,
    "maxX" : 1325,
    "minY" : 309,
    "maxY" : 374,
    "prop" : {
      "x" : 1201,
      "y" : 309,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1202,
      "y" : 311
    },
    "connectors" : [ {
      "edgeId" : 61,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1198,
          "y" : 329
        },
        "to" : {
          "x" : 1144,
          "y" : 360
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1165,
            "y" : 338
          },
          "b" : {
            "x" : 1177,
            "y" : 350
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1171,
            "y" : 344
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1194,
          "y" : 336
        },
        "b" : {
          "x" : 1198,
          "y" : 329
        },
        "c" : {
          "x" : 1190,
          "y" : 329
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1190,
          "y" : 329
        }
      }
    }, {
      "edgeId" : 63,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1234,
          "y" : 329
        },
        "to" : {
          "x" : 1325,
          "y" : 374
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1273,
            "y" : 345
          },
          "b" : {
            "x" : 1285,
            "y" : 357
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1279,
            "y" : 351
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1242,
          "y" : 328
        },
        "b" : {
          "x" : 1234,
          "y" : 329
        },
        "c" : {
          "x" : 1238,
          "y" : 336
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1238,
          "y" : 336
        }
      }
    } ]
  }, {
    "id" : 10,
    "reactomeId" : 442654,
    "displayName" : "SLC41A1,2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 525,
      "y" : 754
    },
    "isFadeOut" : true,
    "minX" : 445,
    "maxX" : 562,
    "minY" : 739,
    "maxY" : 769,
    "prop" : {
      "x" : 488,
      "y" : 739,
      "width" : 74,
      "height" : 30
    },
    "textPosition" : {
      "x" : 488,
      "y" : 743
    },
    "connectors" : [ {
      "edgeId" : 7,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 482,
          "y" : 752
        },
        "to" : {
          "x" : 453,
          "y" : 751
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 449,
          "y" : 751
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 449,
          "y" : 751
        }
      }
    } ]
  }, {
    "id" : 267,
    "reactomeId" : 5339575,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1157,
      "y" : 423
    },
    "isFadeOut" : true,
    "minX" : 1141,
    "maxX" : 1173,
    "minY" : 359,
    "maxY" : 439,
    "prop" : {
      "x" : 1141,
      "y" : 408,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1143,
      "y" : 413
    },
    "connectors" : [ {
      "edgeId" : 61,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1153,
          "y" : 405
        },
        "to" : {
          "x" : 1141,
          "y" : 359
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1141,
            "y" : 376
          },
          "b" : {
            "x" : 1153,
            "y" : 388
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1147,
            "y" : 382
          }
        }
      }
    } ]
  }, {
    "id" : 12,
    "reactomeId" : 435347,
    "displayName" : "Fe2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 285,
      "y" : 17
    },
    "isFadeOut" : true,
    "minX" : 251,
    "maxX" : 305,
    "minY" : 0,
    "maxY" : 136,
    "prop" : {
      "x" : 265,
      "y" : 0,
      "width" : 40,
      "height" : 34
    },
    "textPosition" : {
      "x" : 269,
      "y" : 0
    },
    "connectors" : [ {
      "edgeId" : 11,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 280,
          "y" : 37
        },
        "to" : {
          "x" : 251,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 14,
    "reactomeId" : 445829,
    "displayName" : "Divalent metals transported by NRAMP1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 101,
      "y" : 243
    },
    "isFadeOut" : true,
    "minX" : 49,
    "maxX" : 178,
    "minY" : 215,
    "maxY" : 304,
    "prop" : {
      "x" : 49,
      "y" : 215,
      "width" : 105,
      "height" : 56
    },
    "textPosition" : {
      "x" : 48,
      "y" : 218
    },
    "connectors" : [ {
      "edgeId" : 25,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 136,
          "y" : 277
        },
        "to" : {
          "x" : 178,
          "y" : 304
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 271,
    "reactomeId" : 111627,
    "displayName" : "HCO3-",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 847,
      "y" : 220
    },
    "isFadeOut" : true,
    "minX" : 822,
    "maxX" : 873,
    "minY" : 135,
    "maxY" : 236,
    "prop" : {
      "x" : 822,
      "y" : 205,
      "width" : 51,
      "height" : 31
    },
    "textPosition" : {
      "x" : 824,
      "y" : 210
    },
    "connectors" : [ {
      "edgeId" : 81,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 846,
          "y" : 202
        },
        "to" : {
          "x" : 845,
          "y" : 135
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 839,
            "y" : 162
          },
          "b" : {
            "x" : 851,
            "y" : 174
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 845,
            "y" : 168
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 842,
          "y" : 195
        },
        "b" : {
          "x" : 846,
          "y" : 202
        },
        "c" : {
          "x" : 850,
          "y" : 195
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 850,
          "y" : 195
        }
      }
    } ]
  }, {
    "id" : 272,
    "reactomeId" : 425425,
    "displayName" : "HCO3-",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 845,
      "y" : 56
    },
    "isFadeOut" : true,
    "minX" : 820,
    "maxX" : 871,
    "minY" : 41,
    "maxY" : 135,
    "prop" : {
      "x" : 820,
      "y" : 41,
      "width" : 51,
      "height" : 31
    },
    "textPosition" : {
      "x" : 822,
      "y" : 46
    },
    "connectors" : [ {
      "edgeId" : 81,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 844,
          "y" : 75
        },
        "to" : {
          "x" : 843,
          "y" : 135
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 837,
            "y" : 99
          },
          "b" : {
            "x" : 849,
            "y" : 111
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 843,
            "y" : 105
          }
        }
      }
    } ]
  }, {
    "id" : 17,
    "reactomeId" : 437299,
    "displayName" : "SLC31A1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 350,
      "y" : 751
    },
    "isFadeOut" : true,
    "minX" : 272,
    "maxX" : 384,
    "minY" : 736,
    "maxY" : 766,
    "prop" : {
      "x" : 316,
      "y" : 736,
      "width" : 68,
      "height" : 30
    },
    "textPosition" : {
      "x" : 319,
      "y" : 740
    },
    "connectors" : [ {
      "edgeId" : 6,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 313,
          "y" : 752
        },
        "to" : {
          "x" : 280,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 276,
          "y" : 754
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 276,
          "y" : 754
        }
      }
    } ]
  }, {
    "id" : 274,
    "reactomeId" : 74113,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 956,
      "y" : 819
    },
    "isFadeOut" : true,
    "minX" : 845,
    "maxX" : 1040,
    "minY" : 753,
    "maxY" : 835,
    "prop" : {
      "x" : 937,
      "y" : 804,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 938,
      "y" : 809
    },
    "connectors" : [ {
      "edgeId" : 337,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 934,
          "y" : 807
        },
        "to" : {
          "x" : 845,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 273,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 978,
          "y" : 804
        },
        "to" : {
          "x" : 1040,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1003,
            "y" : 772
          },
          "b" : {
            "x" : 1015,
            "y" : 784
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1009,
            "y" : 778
          }
        }
      }
    } ]
  }, {
    "id" : 18,
    "reactomeId" : 904821,
    "displayName" : "SLC40A1:HEPH:6Cu2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 382,
      "y" : 138
    },
    "isFadeOut" : true,
    "minX" : 348,
    "maxX" : 454,
    "minY" : 113,
    "maxY" : 164,
    "prop" : {
      "x" : 348,
      "y" : 113,
      "width" : 68,
      "height" : 51
    },
    "textPosition" : {
      "x" : 349,
      "y" : 115
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 13,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 419,
          "y" : 137
        },
        "to" : {
          "x" : 446,
          "y" : 137
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 450,
          "y" : 137
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 450,
          "y" : 137
        }
      }
    } ]
  }, {
    "id" : 275,
    "reactomeId" : 83910,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 949,
      "y" : 673
    },
    "minX" : 507,
    "maxX" : 1041,
    "minY" : 443,
    "maxY" : 753,
    "prop" : {
      "x" : 930,
      "y" : 658,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 931,
      "y" : 663
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 963,
          "y" : 663
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 963,
          "y" : 663
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 337,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 927,
          "y" : 687
        },
        "to" : {
          "x" : 843,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 924,
          "y" : 694
        },
        "b" : {
          "x" : 927,
          "y" : 687
        },
        "c" : {
          "x" : 919,
          "y" : 688
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 919,
          "y" : 688
        }
      }
    }, {
      "edgeId" : 273,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 966,
          "y" : 692
        },
        "to" : {
          "x" : 1041,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 997,
            "y" : 716
          },
          "b" : {
            "x" : 1009,
            "y" : 728
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1003,
            "y" : 722
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 974,
          "y" : 693
        },
        "b" : {
          "x" : 966,
          "y" : 692
        },
        "c" : {
          "x" : 969,
          "y" : 699
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 969,
          "y" : 699
        }
      }
    }, {
      "edgeId" : 345,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 927,
          "y" : 663
        },
        "to" : {
          "x" : 507,
          "y" : 443
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 363,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 927,
          "y" : 667
        },
        "to" : {
          "x" : 516,
          "y" : 553
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 142767,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 927,
          "y" : 667
        },
        "to" : {
          "x" : 516,
          "y" : 553
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 19,
    "reactomeId" : 904825,
    "displayName" : "SLC40A1:CP:6Cu2+",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 612,
      "y" : 139
    },
    "isFadeOut" : true,
    "minX" : 536,
    "maxX" : 648,
    "minY" : 120,
    "maxY" : 159,
    "prop" : {
      "x" : 576,
      "y" : 120,
      "width" : 72,
      "height" : 39
    },
    "textPosition" : {
      "x" : 577,
      "y" : 124
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 16,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 573,
          "y" : 139
        },
        "to" : {
          "x" : 544,
          "y" : 139
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 540,
          "y" : 139
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 540,
          "y" : 139
        }
      }
    } ]
  }, {
    "id" : 276,
    "reactomeId" : 425675,
    "displayName" : "SLC8A1,2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 939,
      "y" : 754
    },
    "isFadeOut" : true,
    "minX" : 899,
    "maxX" : 1031,
    "minY" : 741,
    "maxY" : 768,
    "prop" : {
      "x" : 899,
      "y" : 741,
      "width" : 80,
      "height" : 27
    },
    "textPosition" : {
      "x" : 900,
      "y" : 744
    },
    "connectors" : [ {
      "edgeId" : 273,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 985,
          "y" : 753
        },
        "to" : {
          "x" : 1023,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1027,
          "y" : 753
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1027,
          "y" : 753
        }
      }
    } ]
  }, {
    "id" : 277,
    "reactomeId" : 5490313,
    "displayName" : "SRI",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1049,
      "y" : 620
    },
    "isFadeOut" : true,
    "minX" : 1036,
    "maxX" : 1062,
    "minY" : 609,
    "maxY" : 744,
    "prop" : {
      "x" : 1036,
      "y" : 609,
      "width" : 26,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1037,
      "y" : 603
    },
    "connectors" : [ {
      "edgeId" : 273,
      "type" : "ACTIVATOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1048,
          "y" : 635
        },
        "to" : {
          "x" : 1040,
          "y" : 744
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1037,
          "y" : 737
        },
        "b" : {
          "x" : 1040,
          "y" : 744
        },
        "c" : {
          "x" : 1044,
          "y" : 737
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1044,
          "y" : 737
        }
      }
    } ]
  }, {
    "id" : 21,
    "reactomeId" : 29926,
    "displayName" : "Mg2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 438,
      "y" : 678
    },
    "isFadeOut" : true,
    "minX" : 420,
    "maxX" : 457,
    "minY" : 659,
    "maxY" : 697,
    "prop" : {
      "x" : 420,
      "y" : 659,
      "width" : 37,
      "height" : 38
    },
    "textPosition" : {
      "x" : 421,
      "y" : 660
    },
    "connectors" : [ {
      "edgeId" : 7,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 278,
    "reactomeId" : 9016707,
    "displayName" : "CALM1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1002,
      "y" : 605
    },
    "isFadeOut" : true,
    "minX" : 979,
    "maxX" : 1041,
    "minY" : 594,
    "maxY" : 745,
    "prop" : {
      "x" : 979,
      "y" : 594,
      "width" : 47,
      "height" : 23
    },
    "textPosition" : {
      "x" : 982,
      "y" : 588
    },
    "connectors" : [ {
      "edgeId" : 273,
      "type" : "INHIBITOR",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1004,
          "y" : 620
        },
        "to" : {
          "x" : 1037,
          "y" : 744
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1033,
          "y" : 745
        },
        "b" : {
          "x" : 1041,
          "y" : 743
        },
        "c" : {
          "x" : 1037,
          "y" : 744
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1037,
          "y" : 744
        }
      }
    } ]
  }, {
    "id" : 22,
    "reactomeId" : 445832,
    "displayName" : "Divalent metals transported by NRAMP1",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 149,
      "y" : 381
    },
    "isFadeOut" : true,
    "minX" : 97,
    "maxX" : 201,
    "minY" : 305,
    "maxY" : 410,
    "prop" : {
      "x" : 97,
      "y" : 353,
      "width" : 104,
      "height" : 57
    },
    "textPosition" : {
      "x" : 95,
      "y" : 357
    },
    "connectors" : [ {
      "edgeId" : 25,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 159,
          "y" : 347
        },
        "to" : {
          "x" : 178,
          "y" : 305
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 158,
          "y" : 339
        },
        "b" : {
          "x" : 159,
          "y" : 347
        },
        "c" : {
          "x" : 166,
          "y" : 342
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 166,
          "y" : 342
        }
      }
    } ]
  }, {
    "id" : 23,
    "reactomeId" : 435359,
    "displayName" : "SLC11A2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 175,
      "y" : 135
    },
    "isFadeOut" : true,
    "minX" : 144,
    "maxX" : 241,
    "minY" : 122,
    "maxY" : 149,
    "prop" : {
      "x" : 144,
      "y" : 122,
      "width" : 62,
      "height" : 27
    },
    "textPosition" : {
      "x" : 144,
      "y" : 125
    },
    "connectors" : [ {
      "edgeId" : 11,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 209,
          "y" : 135
        },
        "to" : {
          "x" : 233,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 237,
          "y" : 136
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 237,
          "y" : 136
        }
      }
    } ]
  }, {
    "id" : 280,
    "reactomeId" : 74016,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1105,
      "y" : 674
    },
    "isFadeOut" : true,
    "minX" : 1040,
    "maxX" : 1185,
    "minY" : 659,
    "maxY" : 754,
    "prop" : {
      "x" : 1083,
      "y" : 659,
      "width" : 44,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1084,
      "y" : 664
    },
    "connectors" : [ {
      "edgeId" : 273,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1092,
          "y" : 693
        },
        "to" : {
          "x" : 1040,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 283,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1120,
          "y" : 693
        },
        "to" : {
          "x" : 1185,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 24,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 199,
      "y" : 229
    },
    "isFadeOut" : true,
    "minX" : 178,
    "maxX" : 251,
    "minY" : 137,
    "maxY" : 305,
    "prop" : {
      "x" : 184,
      "y" : 216,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 185,
      "y" : 218
    },
    "connectors" : [ {
      "edgeId" : 11,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 206,
          "y" : 213
        },
        "to" : {
          "x" : 251,
          "y" : 137
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 206,
          "y" : 205
        },
        "b" : {
          "x" : 206,
          "y" : 213
        },
        "c" : {
          "x" : 213,
          "y" : 209
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 213,
          "y" : 209
        }
      }
    }, {
      "edgeId" : 25,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 195,
          "y" : 245
        },
        "to" : {
          "x" : 178,
          "y" : 305
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 197,
          "y" : 253
        },
        "b" : {
          "x" : 195,
          "y" : 245
        },
        "c" : {
          "x" : 189,
          "y" : 251
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 189,
          "y" : 251
        }
      }
    } ]
  }, {
    "id" : 282,
    "reactomeId" : 74112,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1113,
      "y" : 822
    },
    "isFadeOut" : true,
    "minX" : 1041,
    "maxX" : 1187,
    "minY" : 751,
    "maxY" : 838,
    "prop" : {
      "x" : 1091,
      "y" : 807,
      "width" : 44,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1092,
      "y" : 812
    },
    "connectors" : [ {
      "edgeId" : 273,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1096,
          "y" : 804
        },
        "to" : {
          "x" : 1041,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1088,
          "y" : 802
        },
        "b" : {
          "x" : 1096,
          "y" : 804
        },
        "c" : {
          "x" : 1094,
          "y" : 796
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1094,
          "y" : 796
        }
      }
    }, {
      "edgeId" : 283,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1129,
          "y" : 804
        },
        "to" : {
          "x" : 1187,
          "y" : 751
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1131,
          "y" : 796
        },
        "b" : {
          "x" : 1129,
          "y" : 804
        },
        "c" : {
          "x" : 1137,
          "y" : 802
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1137,
          "y" : 802
        }
      }
    } ]
  }, {
    "id" : 26,
    "reactomeId" : 437102,
    "displayName" : "SLC30A10",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 103,
      "y" : 752
    },
    "isFadeOut" : true,
    "minX" : 66,
    "maxX" : 171,
    "minY" : 737,
    "maxY" : 768,
    "prop" : {
      "x" : 66,
      "y" : 737,
      "width" : 74,
      "height" : 31
    },
    "textPosition" : {
      "x" : 68,
      "y" : 742
    },
    "connectors" : [ {
      "edgeId" : 15,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 143,
          "y" : 752
        },
        "to" : {
          "x" : 163,
          "y" : 752
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 167,
          "y" : 752
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 167,
          "y" : 752
        }
      }
    } ]
  }, {
    "id" : 27,
    "reactomeId" : 437103,
    "displayName" : "SLC11A1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 253,
      "y" : 304
    },
    "isFadeOut" : true,
    "minX" : 185,
    "maxX" : 286,
    "minY" : 290,
    "maxY" : 319,
    "prop" : {
      "x" : 221,
      "y" : 290,
      "width" : 65,
      "height" : 29
    },
    "textPosition" : {
      "x" : 222,
      "y" : 294
    },
    "connectors" : [ {
      "edgeId" : 25,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 218,
          "y" : 304
        },
        "to" : {
          "x" : 193,
          "y" : 304
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 189,
          "y" : 304
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 189,
          "y" : 304
        }
      }
    } ]
  }, {
    "id" : 28,
    "reactomeId" : 1470067,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 253,
      "y" : 359
    },
    "isFadeOut" : true,
    "minX" : 178,
    "maxX" : 268,
    "minY" : 304,
    "maxY" : 373,
    "prop" : {
      "x" : 238,
      "y" : 345,
      "width" : 30,
      "height" : 28
    },
    "textPosition" : {
      "x" : 239,
      "y" : 348
    },
    "connectors" : [ {
      "edgeId" : 25,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 235,
          "y" : 348
        },
        "to" : {
          "x" : 178,
          "y" : 304
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 284,
    "reactomeId" : 29804,
    "displayName" : "K+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1258,
      "y" : 675
    },
    "isFadeOut" : true,
    "minX" : 1185,
    "maxX" : 1324,
    "minY" : 578,
    "maxY" : 754,
    "prop" : {
      "x" : 1242,
      "y" : 660,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1245,
      "y" : 665
    },
    "connectors" : [ {
      "edgeId" : 283,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1243,
          "y" : 694
        },
        "to" : {
          "x" : 1185,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 300,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1268,
          "y" : 657
        },
        "to" : {
          "x" : 1324,
          "y" : 578
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1269,
          "y" : 649
        },
        "b" : {
          "x" : 1268,
          "y" : 657
        },
        "c" : {
          "x" : 1275,
          "y" : 654
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1275,
          "y" : 654
        }
      }
    } ]
  }, {
    "id" : 285,
    "reactomeId" : 74126,
    "displayName" : "K+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1264,
      "y" : 823
    },
    "isFadeOut" : true,
    "minX" : 1187,
    "maxX" : 1280,
    "minY" : 751,
    "maxY" : 839,
    "prop" : {
      "x" : 1248,
      "y" : 808,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1251,
      "y" : 813
    },
    "connectors" : [ {
      "edgeId" : 283,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1245,
          "y" : 808
        },
        "to" : {
          "x" : 1187,
          "y" : 751
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1237,
          "y" : 806
        },
        "b" : {
          "x" : 1245,
          "y" : 808
        },
        "c" : {
          "x" : 1243,
          "y" : 800
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1243,
          "y" : 800
        }
      }
    } ]
  }, {
    "id" : 29,
    "reactomeId" : 71067,
    "displayName" : "Fe2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 328,
      "y" : 207
    },
    "isFadeOut" : true,
    "minX" : 251,
    "maxX" : 348,
    "minY" : 137,
    "maxY" : 223,
    "prop" : {
      "x" : 309,
      "y" : 191,
      "width" : 39,
      "height" : 32
    },
    "textPosition" : {
      "x" : 313,
      "y" : 190
    },
    "connectors" : [ {
      "edgeId" : 11,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 310,
          "y" : 188
        },
        "to" : {
          "x" : 251,
          "y" : 137
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 302,
          "y" : 186
        },
        "b" : {
          "x" : 310,
          "y" : 188
        },
        "c" : {
          "x" : 307,
          "y" : 180
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 307,
          "y" : 180
        }
      }
    } ]
  }, {
    "id" : 30,
    "reactomeId" : 351626,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 206,
      "y" : 86
    },
    "isFadeOut" : true,
    "minX" : 192,
    "maxX" : 251,
    "minY" : 72,
    "maxY" : 136,
    "prop" : {
      "x" : 192,
      "y" : 72,
      "width" : 28,
      "height" : 29
    },
    "textPosition" : {
      "x" : 192,
      "y" : 76
    },
    "connectors" : [ {
      "edgeId" : 11,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 219,
          "y" : 104
        },
        "to" : {
          "x" : 251,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 286,
    "reactomeId" : 425657,
    "displayName" : "SLC24A1-4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1296,
      "y" : 755
    },
    "isFadeOut" : true,
    "minX" : 1193,
    "maxX" : 1335,
    "minY" : 742,
    "maxY" : 769,
    "prop" : {
      "x" : 1257,
      "y" : 742,
      "width" : 78,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1259,
      "y" : 745
    },
    "connectors" : [ {
      "edgeId" : 283,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1251,
          "y" : 753
        },
        "to" : {
          "x" : 1201,
          "y" : 751
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1197,
          "y" : 751
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1197,
          "y" : 751
        }
      }
    } ]
  }, {
    "id" : 37,
    "reactomeId" : 435347,
    "displayName" : "Fe2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 489,
      "y" : 18
    },
    "isFadeOut" : true,
    "minX" : 469,
    "maxX" : 509,
    "minY" : 1,
    "maxY" : 35,
    "prop" : {
      "x" : 469,
      "y" : 1,
      "width" : 40,
      "height" : 34
    },
    "textPosition" : {
      "x" : 473,
      "y" : 1
    },
    "connectors" : [ {
      "edgeId" : 13,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 16,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39,
    "reactomeId" : 71067,
    "displayName" : "Fe2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 459,
      "y" : 214
    },
    "isFadeOut" : true,
    "minX" : 440,
    "maxX" : 479,
    "minY" : 198,
    "maxY" : 230,
    "prop" : {
      "x" : 440,
      "y" : 198,
      "width" : 39,
      "height" : 32
    },
    "textPosition" : {
      "x" : 444,
      "y" : 197
    },
    "connectors" : [ {
      "edgeId" : 13,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 16,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 297,
    "reactomeId" : 83910,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1184,
      "y" : 675
    },
    "isFadeOut" : true,
    "minX" : 1165,
    "maxX" : 1324,
    "minY" : 581,
    "maxY" : 751,
    "prop" : {
      "x" : 1165,
      "y" : 660,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1166,
      "y" : 665
    },
    "connectors" : [ {
      "edgeId" : 283,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1184,
          "y" : 694
        },
        "to" : {
          "x" : 1187,
          "y" : 751
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1179,
            "y" : 716
          },
          "b" : {
            "x" : 1191,
            "y" : 728
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1185,
            "y" : 722
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1188,
          "y" : 701
        },
        "b" : {
          "x" : 1184,
          "y" : 694
        },
        "c" : {
          "x" : 1180,
          "y" : 701
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1180,
          "y" : 701
        }
      }
    }, {
      "edgeId" : 300,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1206,
          "y" : 662
        },
        "to" : {
          "x" : 1324,
          "y" : 581
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1259,
            "y" : 615
          },
          "b" : {
            "x" : 1271,
            "y" : 627
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1265,
            "y" : 621
          }
        }
      }
    } ]
  }, {
    "id" : 299,
    "reactomeId" : 74113,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1187,
      "y" : 819
    },
    "isFadeOut" : true,
    "minX" : 1168,
    "maxX" : 1206,
    "minY" : 754,
    "maxY" : 835,
    "prop" : {
      "x" : 1168,
      "y" : 804,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1169,
      "y" : 809
    },
    "connectors" : [ {
      "edgeId" : 283,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1186,
          "y" : 801
        },
        "to" : {
          "x" : 1185,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1179,
            "y" : 771
          },
          "b" : {
            "x" : 1191,
            "y" : 783
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1185,
            "y" : 777
          }
        }
      }
    } ]
  }, {
    "id" : 44,
    "reactomeId" : 29426,
    "displayName" : "Zn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1189,
      "y" : 246
    },
    "isFadeOut" : true,
    "minX" : 704,
    "maxX" : 1681,
    "minY" : 135,
    "maxY" : 374,
    "prop" : {
      "x" : 1167,
      "y" : 231,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1168,
      "y" : 236
    },
    "connectors" : [ {
      "edgeId" : 68,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 71,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 73,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 75,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 78,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 81,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1164,
          "y" : 238
        },
        "to" : {
          "x" : 845,
          "y" : 135
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1156,
          "y" : 240
        },
        "b" : {
          "x" : 1164,
          "y" : 238
        },
        "c" : {
          "x" : 1159,
          "y" : 232
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1159,
          "y" : 232
        }
      }
    }, {
      "edgeId" : 84,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 47,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1164,
          "y" : 246
        },
        "to" : {
          "x" : 704,
          "y" : 247
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 368,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1215,
          "y" : 242
        },
        "to" : {
          "x" : 1626,
          "y" : 176
        }
      }, {
        "from" : {
          "x" : 1626,
          "y" : 176
        },
        "to" : {
          "x" : 1681,
          "y" : 139
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 52,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 56,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 61,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1182,
          "y" : 265
        },
        "to" : {
          "x" : 1141,
          "y" : 359
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 63,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1205,
          "y" : 265
        },
        "to" : {
          "x" : 1324,
          "y" : 374
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 301,
    "reactomeId" : 5626313,
    "displayName" : "K+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1295,
      "y" : 502
    },
    "isFadeOut" : true,
    "minX" : 1279,
    "maxX" : 1324,
    "minY" : 487,
    "maxY" : 581,
    "prop" : {
      "x" : 1279,
      "y" : 487,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1282,
      "y" : 492
    },
    "connectors" : [ {
      "edgeId" : 300,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1300,
          "y" : 521
        },
        "to" : {
          "x" : 1324,
          "y" : 581
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 45,
    "reactomeId" : 158417,
    "displayName" : "Zn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1178,
      "y" : 19
    },
    "isFadeOut" : true,
    "minX" : 843,
    "maxX" : 1680,
    "minY" : 4,
    "maxY" : 138,
    "prop" : {
      "x" : 1156,
      "y" : 4,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1157,
      "y" : 9
    },
    "connectors" : [ {
      "edgeId" : 71,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 73,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 75,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 81,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1153,
          "y" : 26
        },
        "to" : {
          "x" : 843,
          "y" : 135
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 84,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 368,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1204,
          "y" : 22
        },
        "to" : {
          "x" : 1622,
          "y" : 90
        }
      }, {
        "from" : {
          "x" : 1622,
          "y" : 90
        },
        "to" : {
          "x" : 1680,
          "y" : 138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1211,
          "y" : 19
        },
        "b" : {
          "x" : 1204,
          "y" : 22
        },
        "c" : {
          "x" : 1210,
          "y" : 27
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1210,
          "y" : 27
        }
      }
    } ]
  }, {
    "id" : 302,
    "reactomeId" : 167012,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1350,
      "y" : 499
    },
    "isFadeOut" : true,
    "minX" : 1324,
    "maxX" : 1373,
    "minY" : 484,
    "maxY" : 581,
    "prop" : {
      "x" : 1328,
      "y" : 484,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1329,
      "y" : 489
    },
    "connectors" : [ {
      "edgeId" : 300,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1345,
          "y" : 518
        },
        "to" : {
          "x" : 1324,
          "y" : 581
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 303,
    "reactomeId" : 425958,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1413,
      "y" : 501
    },
    "isFadeOut" : true,
    "minX" : 1324,
    "maxX" : 1568,
    "minY" : 486,
    "maxY" : 578,
    "prop" : {
      "x" : 1394,
      "y" : 486,
      "width" : 39,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1396,
      "y" : 491
    },
    "connectors" : [ {
      "edgeId" : 354,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1436,
          "y" : 510
        },
        "to" : {
          "x" : 1568,
          "y" : 576
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1444,
          "y" : 510
        },
        "b" : {
          "x" : 1436,
          "y" : 510
        },
        "c" : {
          "x" : 1440,
          "y" : 517
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1440,
          "y" : 517
        }
      }
    }, {
      "edgeId" : 300,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1395,
          "y" : 520
        },
        "to" : {
          "x" : 1324,
          "y" : 578
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1353,
            "y" : 543
          },
          "b" : {
            "x" : 1365,
            "y" : 555
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1359,
            "y" : 549
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1392,
          "y" : 527
        },
        "b" : {
          "x" : 1395,
          "y" : 520
        },
        "c" : {
          "x" : 1387,
          "y" : 521
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1387,
          "y" : 521
        }
      }
    } ]
  }, {
    "id" : 48,
    "reactomeId" : 435350,
    "displayName" : "Zn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 622,
      "y" : 285
    },
    "isFadeOut" : true,
    "minX" : 600,
    "maxX" : 705,
    "minY" : 246,
    "maxY" : 301,
    "prop" : {
      "x" : 600,
      "y" : 270,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 601,
      "y" : 275
    },
    "connectors" : [ {
      "edgeId" : 47,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 648,
          "y" : 274
        },
        "to" : {
          "x" : 705,
          "y" : 246
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 652,
          "y" : 267
        },
        "b" : {
          "x" : 648,
          "y" : 274
        },
        "c" : {
          "x" : 656,
          "y" : 275
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 656,
          "y" : 275
        }
      }
    } ]
  }, {
    "id" : 304,
    "reactomeId" : 425660,
    "displayName" : "SLC24A5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1408,
      "y" : 579
    },
    "isFadeOut" : true,
    "minX" : 1332,
    "maxX" : 1441,
    "minY" : 567,
    "maxY" : 592,
    "prop" : {
      "x" : 1376,
      "y" : 567,
      "width" : 65,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1377,
      "y" : 569
    },
    "connectors" : [ {
      "edgeId" : 300,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1373,
          "y" : 579
        },
        "to" : {
          "x" : 1340,
          "y" : 580
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1336,
          "y" : 580
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1336,
          "y" : 580
        }
      }
    } ]
  }, {
    "id" : 49,
    "reactomeId" : 435363,
    "displayName" : "SLC30A2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 614,
      "y" : 226
    },
    "isFadeOut" : true,
    "minX" : 582,
    "maxX" : 696,
    "minY" : 213,
    "maxY" : 247,
    "prop" : {
      "x" : 582,
      "y" : 213,
      "width" : 65,
      "height" : 27
    },
    "textPosition" : {
      "x" : 583,
      "y" : 216
    },
    "connectors" : [ {
      "edgeId" : 47,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 650,
          "y" : 233
        },
        "to" : {
          "x" : 688,
          "y" : 242
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 692,
          "y" : 243
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 692,
          "y" : 243
        }
      }
    } ]
  }, {
    "id" : 142768,
    "reactomeId" : 5661096,
    "displayName" : "SLC9A9 R423*",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 499,
      "y" : 610
    },
    "isDisease" : true,
    "minX" : 469,
    "maxX" : 535,
    "minY" : 561,
    "maxY" : 624,
    "prop" : {
      "x" : 469,
      "y" : 597,
      "width" : 60,
      "height" : 27
    },
    "textPosition" : {
      "x" : 470,
      "y" : 593
    },
    "needDashedBorder" : true,
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 529,
          "y" : 597
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 529,
          "y" : 597
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 142767,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 503,
          "y" : 594
        },
        "to" : {
          "x" : 512,
          "y" : 569
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 514,
          "y" : 565
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 514,
          "y" : 565
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 53,
    "reactomeId" : 437093,
    "displayName" : "Zn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 888,
      "y" : 420
    },
    "isFadeOut" : true,
    "minX" : 866,
    "maxX" : 911,
    "minY" : 405,
    "maxY" : 436,
    "prop" : {
      "x" : 866,
      "y" : 405,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 867,
      "y" : 410
    },
    "connectors" : [ {
      "edgeId" : 52,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54,
    "reactomeId" : 4084713,
    "displayName" : "SLC30A3-like Protein",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 786,
      "y" : 356
    },
    "isFadeOut" : true,
    "minX" : 749,
    "maxX" : 880,
    "minY" : 337,
    "maxY" : 376,
    "prop" : {
      "x" : 749,
      "y" : 337,
      "width" : 75,
      "height" : 39
    },
    "textPosition" : {
      "x" : 753,
      "y" : 332
    },
    "connectors" : [ {
      "edgeId" : 52,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 830,
          "y" : 356
        },
        "to" : {
          "x" : 872,
          "y" : 357
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 876,
          "y" : 357
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 876,
          "y" : 357
        }
      }
    } ]
  }, {
    "id" : 57,
    "reactomeId" : 216785,
    "displayName" : "Zn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1099,
      "y" : 412
    },
    "isFadeOut" : true,
    "minX" : 1077,
    "maxX" : 1144,
    "minY" : 360,
    "maxY" : 428,
    "prop" : {
      "x" : 1077,
      "y" : 397,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1078,
      "y" : 402
    },
    "connectors" : [ {
      "edgeId" : 56,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 61,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1112,
          "y" : 394
        },
        "to" : {
          "x" : 1144,
          "y" : 360
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1114,
          "y" : 386
        },
        "b" : {
          "x" : 1112,
          "y" : 394
        },
        "c" : {
          "x" : 1120,
          "y" : 392
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1120,
          "y" : 392
        }
      }
    } ]
  }, {
    "id" : 58,
    "reactomeId" : 437105,
    "displayName" : "SLC30A5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1017,
      "y" : 366
    },
    "isFadeOut" : true,
    "minX" : 982,
    "maxX" : 1089,
    "minY" : 353,
    "maxY" : 380,
    "prop" : {
      "x" : 982,
      "y" : 353,
      "width" : 71,
      "height" : 27
    },
    "textPosition" : {
      "x" : 986,
      "y" : 356
    },
    "connectors" : [ {
      "edgeId" : 56,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1056,
          "y" : 365
        },
        "to" : {
          "x" : 1081,
          "y" : 364
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1085,
          "y" : 364
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1085,
          "y" : 364
        }
      }
    } ]
  }, {
    "id" : 318,
    "reactomeId" : 74016,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1389,
      "y" : 672
    },
    "isFadeOut" : true,
    "minX" : 1324,
    "maxX" : 1462,
    "minY" : 578,
    "maxY" : 752,
    "prop" : {
      "x" : 1367,
      "y" : 657,
      "width" : 44,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1368,
      "y" : 662
    },
    "connectors" : [ {
      "edgeId" : 300,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1378,
          "y" : 654
        },
        "to" : {
          "x" : 1324,
          "y" : 578
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1371,
          "y" : 651
        },
        "b" : {
          "x" : 1378,
          "y" : 654
        },
        "c" : {
          "x" : 1377,
          "y" : 646
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1377,
          "y" : 646
        }
      }
    }, {
      "edgeId" : 319,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1403,
          "y" : 691
        },
        "to" : {
          "x" : 1462,
          "y" : 752
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 62,
    "reactomeId" : 437106,
    "displayName" : "SLC30A8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1212,
      "y" : 397
    },
    "isFadeOut" : true,
    "minX" : 1150,
    "maxX" : 1243,
    "minY" : 360,
    "maxY" : 409,
    "prop" : {
      "x" : 1182,
      "y" : 386,
      "width" : 61,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1185,
      "y" : 380
    },
    "connectors" : [ {
      "edgeId" : 61,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1191,
          "y" : 383
        },
        "to" : {
          "x" : 1157,
          "y" : 365
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1154,
          "y" : 364
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1154,
          "y" : 364
        }
      }
    } ]
  }, {
    "id" : 320,
    "reactomeId" : 425815,
    "displayName" : "Li+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1390,
      "y" : 822
    },
    "isFadeOut" : true,
    "minX" : 1374,
    "maxX" : 1462,
    "minY" : 752,
    "maxY" : 838,
    "prop" : {
      "x" : 1374,
      "y" : 807,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1376,
      "y" : 812
    },
    "connectors" : [ {
      "edgeId" : 319,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1405,
          "y" : 804
        },
        "to" : {
          "x" : 1462,
          "y" : 752
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1427,
            "y" : 772
          },
          "b" : {
            "x" : 1439,
            "y" : 784
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1433,
            "y" : 778
          }
        }
      }
    } ]
  }, {
    "id" : 64,
    "reactomeId" : 216667,
    "displayName" : "Zn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1368,
      "y" : 424
    },
    "isFadeOut" : true,
    "minX" : 1325,
    "maxX" : 1391,
    "minY" : 374,
    "maxY" : 440,
    "prop" : {
      "x" : 1346,
      "y" : 409,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1347,
      "y" : 414
    },
    "connectors" : [ {
      "edgeId" : 68,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 63,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1354,
          "y" : 406
        },
        "to" : {
          "x" : 1325,
          "y" : 374
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1346,
          "y" : 404
        },
        "b" : {
          "x" : 1354,
          "y" : 406
        },
        "c" : {
          "x" : 1352,
          "y" : 398
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1352,
          "y" : 398
        }
      }
    } ]
  }, {
    "id" : 65,
    "reactomeId" : 9817553,
    "displayName" : "SLC30A8 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1284,
      "y" : 413
    },
    "isFadeOut" : true,
    "minX" : 1253,
    "maxX" : 1318,
    "minY" : 377,
    "maxY" : 432,
    "prop" : {
      "x" : 1253,
      "y" : 395,
      "width" : 63,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1252,
      "y" : 397
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 63,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1302,
          "y" : 392
        },
        "to" : {
          "x" : 1311,
          "y" : 384
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1314,
          "y" : 381
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1314,
          "y" : 381
        }
      }
    } ]
  }, {
    "id" : 321,
    "reactomeId" : 425810,
    "displayName" : "Li+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1487,
      "y" : 677
    },
    "isFadeOut" : true,
    "minX" : 1463,
    "maxX" : 1503,
    "minY" : 662,
    "maxY" : 752,
    "prop" : {
      "x" : 1471,
      "y" : 662,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1473,
      "y" : 667
    },
    "connectors" : [ {
      "edgeId" : 319,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1482,
          "y" : 696
        },
        "to" : {
          "x" : 1463,
          "y" : 752
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 1466,
            "y" : 718
          },
          "b" : {
            "x" : 1478,
            "y" : 730
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1472,
            "y" : 724
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1484,
          "y" : 704
        },
        "b" : {
          "x" : 1482,
          "y" : 696
        },
        "c" : {
          "x" : 1476,
          "y" : 701
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1476,
          "y" : 701
        }
      }
    } ]
  }, {
    "id" : 322,
    "reactomeId" : 425655,
    "displayName" : "SLC24A6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1387,
      "y" : 753
    },
    "isFadeOut" : true,
    "minX" : 1354,
    "maxX" : 1453,
    "minY" : 741,
    "maxY" : 766,
    "prop" : {
      "x" : 1354,
      "y" : 741,
      "width" : 67,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1356,
      "y" : 743
    },
    "connectors" : [ {
      "edgeId" : 319,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1424,
          "y" : 753
        },
        "to" : {
          "x" : 1445,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1449,
          "y" : 753
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1449,
          "y" : 753
        }
      }
    } ]
  }, {
    "id" : 69,
    "reactomeId" : 9817590,
    "displayName" : "SLC30A5 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1453,
      "y" : 372
    },
    "isFadeOut" : true,
    "minX" : 1373,
    "maxX" : 1488,
    "minY" : 355,
    "maxY" : 390,
    "prop" : {
      "x" : 1419,
      "y" : 355,
      "width" : 69,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1420,
      "y" : 355
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 68,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1416,
          "y" : 372
        },
        "to" : {
          "x" : 1381,
          "y" : 372
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1377,
          "y" : 372
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1377,
          "y" : 372
        }
      }
    } ]
  }, {
    "id" : 72,
    "reactomeId" : 442327,
    "displayName" : "SLC39A1-4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1161,
      "y" : 139
    },
    "isFadeOut" : true,
    "minX" : 1086,
    "maxX" : 1197,
    "minY" : 128,
    "maxY" : 151,
    "prop" : {
      "x" : 1125,
      "y" : 128,
      "width" : 72,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1128,
      "y" : 122
    },
    "connectors" : [ {
      "edgeId" : 71,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1119,
          "y" : 138
        },
        "to" : {
          "x" : 1094,
          "y" : 138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1090,
          "y" : 138
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1090,
          "y" : 138
        }
      }
    } ]
  }, {
    "id" : 74,
    "reactomeId" : 442360,
    "displayName" : "SLC39A5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1389,
      "y" : 138
    },
    "isFadeOut" : true,
    "minX" : 1317,
    "maxX" : 1421,
    "minY" : 126,
    "maxY" : 151,
    "prop" : {
      "x" : 1358,
      "y" : 126,
      "width" : 63,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1358,
      "y" : 128
    },
    "connectors" : [ {
      "edgeId" : 73,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1355,
          "y" : 138
        },
        "to" : {
          "x" : 1325,
          "y" : 139
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1321,
          "y" : 139
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1321,
          "y" : 139
        }
      }
    } ]
  }, {
    "id" : 76,
    "reactomeId" : 442330,
    "displayName" : "ZIP6/ZIP14",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1601,
      "y" : 139
    },
    "isFadeOut" : true,
    "minX" : 1535,
    "maxX" : 1638,
    "minY" : 128,
    "maxY" : 151,
    "prop" : {
      "x" : 1564,
      "y" : 128,
      "width" : 74,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1567,
      "y" : 122
    },
    "connectors" : [ {
      "edgeId" : 75,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1558,
          "y" : 140
        },
        "to" : {
          "x" : 1543,
          "y" : 140
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1539,
          "y" : 141
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1539,
          "y" : 141
        }
      }
    } ]
  }, {
    "id" : 334,
    "reactomeId" : 74112,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1477,
      "y" : 822
    },
    "isFadeOut" : true,
    "minX" : 1455,
    "maxX" : 1499,
    "minY" : 752,
    "maxY" : 838,
    "prop" : {
      "x" : 1455,
      "y" : 807,
      "width" : 44,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1456,
      "y" : 812
    },
    "connectors" : [ {
      "edgeId" : 319,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1473,
          "y" : 804
        },
        "to" : {
          "x" : 1463,
          "y" : 752
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1468,
          "y" : 798
        },
        "b" : {
          "x" : 1473,
          "y" : 804
        },
        "c" : {
          "x" : 1476,
          "y" : 796
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1476,
          "y" : 796
        }
      }
    } ]
  }, {
    "id" : 79,
    "reactomeId" : 442320,
    "displayName" : "Zn2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1545,
      "y" : 242
    },
    "isFadeOut" : true,
    "minX" : 1523,
    "maxX" : 1568,
    "minY" : 227,
    "maxY" : 258,
    "prop" : {
      "x" : 1523,
      "y" : 227,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1524,
      "y" : 232
    },
    "connectors" : [ {
      "edgeId" : 78,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80,
    "reactomeId" : 442363,
    "displayName" : "SLC39A7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1471,
      "y" : 263
    },
    "isFadeOut" : true,
    "minX" : 1439,
    "maxX" : 1504,
    "minY" : 228,
    "maxY" : 276,
    "prop" : {
      "x" : 1439,
      "y" : 251,
      "width" : 65,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1440,
      "y" : 253
    },
    "connectors" : [ {
      "edgeId" : 78,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1468,
          "y" : 248
        },
        "to" : {
          "x" : 1465,
          "y" : 236
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1464,
          "y" : 232
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1464,
          "y" : 232
        }
      }
    } ]
  }, {
    "id" : 82,
    "reactomeId" : 4127409,
    "displayName" : "SLC39A8-like proteins",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 742,
      "y" : 134
    },
    "isFadeOut" : true,
    "minX" : 699,
    "maxX" : 836,
    "minY" : 114,
    "maxY" : 154,
    "prop" : {
      "x" : 699,
      "y" : 114,
      "width" : 86,
      "height" : 40
    },
    "textPosition" : {
      "x" : 699,
      "y" : 116
    },
    "connectors" : [ {
      "edgeId" : 81,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 791,
          "y" : 134
        },
        "to" : {
          "x" : 828,
          "y" : 134
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 832,
          "y" : 134
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 832,
          "y" : 134
        }
      }
    } ]
  }, {
    "id" : 338,
    "reactomeId" : 425963,
    "displayName" : "SLC9A1-5",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 736,
      "y" : 752
    },
    "isFadeOut" : true,
    "minX" : 699,
    "maxX" : 838,
    "minY" : 742,
    "maxY" : 763,
    "prop" : {
      "x" : 699,
      "y" : 742,
      "width" : 75,
      "height" : 21
    },
    "textPosition" : {
      "x" : 703,
      "y" : 742
    },
    "connectors" : [ {
      "edgeId" : 337,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 780,
          "y" : 752
        },
        "to" : {
          "x" : 830,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 834,
          "y" : 753
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 834,
          "y" : 753
        }
      }
    } ]
  }, {
    "id" : 340,
    "reactomeId" : 351626,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 841,
      "y" : 818
    },
    "isFadeOut" : true,
    "minX" : 827,
    "maxX" : 855,
    "minY" : 753,
    "maxY" : 833,
    "prop" : {
      "x" : 827,
      "y" : 804,
      "width" : 28,
      "height" : 29
    },
    "textPosition" : {
      "x" : 827,
      "y" : 808
    },
    "connectors" : [ {
      "edgeId" : 337,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 841,
          "y" : 801
        },
        "to" : {
          "x" : 843,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 837,
          "y" : 794
        },
        "b" : {
          "x" : 841,
          "y" : 801
        },
        "c" : {
          "x" : 845,
          "y" : 794
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 845,
          "y" : 794
        }
      }
    } ]
  }, {
    "id" : 85,
    "reactomeId" : 442377,
    "displayName" : "SLC39A10",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 985,
      "y" : 139
    },
    "isFadeOut" : true,
    "minX" : 906,
    "maxX" : 1020,
    "minY" : 128,
    "maxY" : 151,
    "prop" : {
      "x" : 951,
      "y" : 128,
      "width" : 69,
      "height" : 23
    },
    "textPosition" : {
      "x" : 954,
      "y" : 122
    },
    "connectors" : [ {
      "edgeId" : 84,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 948,
          "y" : 137
        },
        "to" : {
          "x" : 914,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 910,
          "y" : 136
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 910,
          "y" : 136
        }
      }
    } ]
  }, {
    "id" : 344,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 834,
      "y" : 690
    },
    "isFadeOut" : true,
    "minX" : 819,
    "maxX" : 849,
    "minY" : 677,
    "maxY" : 753,
    "prop" : {
      "x" : 819,
      "y" : 677,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 820,
      "y" : 679
    },
    "connectors" : [ {
      "edgeId" : 337,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 836,
          "y" : 706
        },
        "to" : {
          "x" : 845,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 346,
    "reactomeId" : 425978,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 399,
      "y" : 387
    },
    "isFadeOut" : true,
    "minX" : 383,
    "maxX" : 507,
    "minY" : 372,
    "maxY" : 443,
    "prop" : {
      "x" : 383,
      "y" : 372,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 385,
      "y" : 377
    },
    "connectors" : [ {
      "edgeId" : 345,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 418,
          "y" : 395
        },
        "to" : {
          "x" : 507,
          "y" : 443
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 347,
    "reactomeId" : 425971,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 466,
      "y" : 366
    },
    "isFadeOut" : true,
    "minX" : 447,
    "maxX" : 507,
    "minY" : 351,
    "maxY" : 444,
    "prop" : {
      "x" : 447,
      "y" : 351,
      "width" : 39,
      "height" : 31
    },
    "textPosition" : {
      "x" : 449,
      "y" : 356
    },
    "connectors" : [ {
      "edgeId" : 345,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 474,
          "y" : 385
        },
        "to" : {
          "x" : 507,
          "y" : 444
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 481,
          "y" : 389
        },
        "b" : {
          "x" : 474,
          "y" : 385
        },
        "c" : {
          "x" : 474,
          "y" : 393
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 474,
          "y" : 393
        }
      }
    } ]
  }, {
    "id" : 348,
    "reactomeId" : 4084678,
    "displayName" : "SLC9A6,7",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 413,
      "y" : 443
    },
    "isFadeOut" : true,
    "minX" : 382,
    "maxX" : 498,
    "minY" : 432,
    "maxY" : 455,
    "prop" : {
      "x" : 382,
      "y" : 432,
      "width" : 63,
      "height" : 23
    },
    "textPosition" : {
      "x" : 384,
      "y" : 426
    },
    "connectors" : [ {
      "edgeId" : 345,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 451,
          "y" : 442
        },
        "to" : {
          "x" : 490,
          "y" : 442
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 494,
          "y" : 442
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 494,
          "y" : 442
        }
      }
    } ]
  }, {
    "id" : 353,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 583,
      "y" : 513
    },
    "isFadeOut" : true,
    "minX" : 507,
    "maxX" : 598,
    "minY" : 444,
    "maxY" : 553,
    "prop" : {
      "x" : 568,
      "y" : 500,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 569,
      "y" : 502
    },
    "isCrossed" : true,
    "connectors" : [ {
      "edgeId" : 345,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 568,
          "y" : 497
        },
        "to" : {
          "x" : 507,
          "y" : 444
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 560,
          "y" : 495
        },
        "b" : {
          "x" : 568,
          "y" : 497
        },
        "c" : {
          "x" : 565,
          "y" : 489
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 565,
          "y" : 489
        }
      }
    }, {
      "edgeId" : 363,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 565,
          "y" : 522
        },
        "to" : {
          "x" : 518,
          "y" : 553
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 561,
          "y" : 529
        },
        "b" : {
          "x" : 565,
          "y" : 522
        },
        "c" : {
          "x" : 557,
          "y" : 522
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 557,
          "y" : 522
        }
      }
    }, {
      "edgeId" : 142767,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 565,
          "y" : 522
        },
        "to" : {
          "x" : 518,
          "y" : 553
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 561,
          "y" : 529
        },
        "b" : {
          "x" : 565,
          "y" : 522
        },
        "c" : {
          "x" : 557,
          "y" : 522
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 557,
          "y" : 522
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 355,
    "reactomeId" : 426005,
    "displayName" : "SLC9A7/8",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1641,
      "y" : 547
    },
    "isFadeOut" : true,
    "minX" : 1577,
    "maxX" : 1678,
    "minY" : 535,
    "maxY" : 580,
    "prop" : {
      "x" : 1604,
      "y" : 535,
      "width" : 74,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1608,
      "y" : 537
    },
    "connectors" : [ {
      "edgeId" : 354,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1613,
          "y" : 566
        },
        "to" : {
          "x" : 1585,
          "y" : 574
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1581,
          "y" : 576
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1581,
          "y" : 576
        }
      }
    } ]
  }, {
    "id" : 228,
    "reactomeId" : 74112,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 102,
      "y" : 796
    },
    "isFadeOut" : true,
    "minX" : 80,
    "maxX" : 179,
    "minY" : 751,
    "maxY" : 812,
    "prop" : {
      "x" : 80,
      "y" : 781,
      "width" : 44,
      "height" : 31
    },
    "textPosition" : {
      "x" : 81,
      "y" : 786
    },
    "connectors" : [ {
      "edgeId" : 15,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 127,
          "y" : 783
        },
        "to" : {
          "x" : 179,
          "y" : 751
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 229,
    "reactomeId" : 74016,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 105,
      "y" : 700
    },
    "isFadeOut" : true,
    "minX" : 83,
    "maxX" : 179,
    "minY" : 685,
    "maxY" : 753,
    "prop" : {
      "x" : 83,
      "y" : 685,
      "width" : 44,
      "height" : 31
    },
    "textPosition" : {
      "x" : 84,
      "y" : 690
    },
    "connectors" : [ {
      "edgeId" : 15,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 130,
          "y" : 715
        },
        "to" : {
          "x" : 179,
          "y" : 753
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 138,
          "y" : 716
        },
        "b" : {
          "x" : 130,
          "y" : 715
        },
        "c" : {
          "x" : 133,
          "y" : 722
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 133,
          "y" : 722
        }
      }
    } ]
  }, {
    "id" : 359,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1630,
      "y" : 627
    },
    "isFadeOut" : true,
    "minX" : 1568,
    "maxX" : 1645,
    "minY" : 576,
    "maxY" : 640,
    "prop" : {
      "x" : 1615,
      "y" : 614,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1616,
      "y" : 616
    },
    "connectors" : [ {
      "edgeId" : 354,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1612,
          "y" : 614
        },
        "to" : {
          "x" : 1568,
          "y" : 576
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1604,
          "y" : 612
        },
        "b" : {
          "x" : 1612,
          "y" : 614
        },
        "c" : {
          "x" : 1609,
          "y" : 606
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1609,
          "y" : 606
        }
      }
    } ]
  }, {
    "id" : 360,
    "reactomeId" : 83910,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1554,
      "y" : 661
    },
    "isFadeOut" : true,
    "minX" : 1535,
    "maxX" : 1573,
    "minY" : 577,
    "maxY" : 677,
    "prop" : {
      "x" : 1535,
      "y" : 646,
      "width" : 38,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1536,
      "y" : 651
    },
    "connectors" : [ {
      "edgeId" : 354,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1556,
          "y" : 643
        },
        "to" : {
          "x" : 1567,
          "y" : 577
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 364,
    "reactomeId" : 425999,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 390,
      "y" : 575
    },
    "minX" : 374,
    "maxX" : 516,
    "minY" : 553,
    "maxY" : 591,
    "prop" : {
      "x" : 374,
      "y" : 560,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 376,
      "y" : 565
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 401,
          "y" : 565
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 401,
          "y" : 565
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 363,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 409,
          "y" : 572
        },
        "to" : {
          "x" : 516,
          "y" : 553
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 142767,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 409,
          "y" : 572
        },
        "to" : {
          "x" : 516,
          "y" : 553
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "isDisease" : true
    } ],
    "trivial" : true
  }, {
    "id" : 365,
    "reactomeId" : 425977,
    "displayName" : "Na+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 437,
      "y" : 533
    },
    "isFadeOut" : true,
    "minX" : 418,
    "maxX" : 518,
    "minY" : 518,
    "maxY" : 553,
    "prop" : {
      "x" : 418,
      "y" : 518,
      "width" : 39,
      "height" : 31
    },
    "textPosition" : {
      "x" : 420,
      "y" : 523
    },
    "isCrossed" : true,
    "connectors" : [ {
      "edgeId" : 363,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 460,
          "y" : 537
        },
        "to" : {
          "x" : 518,
          "y" : 553
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 468,
          "y" : 535
        },
        "b" : {
          "x" : 460,
          "y" : 537
        },
        "c" : {
          "x" : 466,
          "y" : 543
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 466,
          "y" : 543
        }
      }
    }, {
      "edgeId" : 142767,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 460,
          "y" : 537
        },
        "to" : {
          "x" : 518,
          "y" : 553
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 468,
          "y" : 535
        },
        "b" : {
          "x" : 460,
          "y" : 537
        },
        "c" : {
          "x" : 466,
          "y" : 543
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 466,
          "y" : 543
        }
      },
      "isDisease" : true
    } ]
  }, {
    "id" : 366,
    "reactomeId" : 425972,
    "displayName" : "SLC9A9",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 499,
      "y" : 610
    },
    "isFadeOut" : true,
    "minX" : 469,
    "maxX" : 529,
    "minY" : 561,
    "maxY" : 624,
    "prop" : {
      "x" : 469,
      "y" : 597,
      "width" : 60,
      "height" : 27
    },
    "textPosition" : {
      "x" : 472,
      "y" : 600
    },
    "connectors" : [ {
      "edgeId" : 363,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 503,
          "y" : 594
        },
        "to" : {
          "x" : 512,
          "y" : 569
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 514,
          "y" : 565
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 514,
          "y" : 565
        }
      }
    } ]
  }, {
    "id" : 369,
    "reactomeId" : 435361,
    "displayName" : "SLC30A1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1746,
      "y" : 137
    },
    "isFadeOut" : true,
    "minX" : 1688,
    "maxX" : 1776,
    "minY" : 126,
    "maxY" : 149,
    "prop" : {
      "x" : 1717,
      "y" : 126,
      "width" : 59,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1719,
      "y" : 120
    },
    "connectors" : [ {
      "edgeId" : 368,
      "type" : "CATALYST",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1714,
          "y" : 137
        },
        "to" : {
          "x" : 1696,
          "y" : 138
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1692,
          "y" : 138
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1692,
          "y" : 138
        }
      }
    } ]
  }, {
    "id" : 371,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1682,
      "y" : 202
    },
    "isFadeOut" : true,
    "minX" : 1667,
    "maxX" : 1697,
    "minY" : 138,
    "maxY" : 215,
    "prop" : {
      "x" : 1667,
      "y" : 189,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1668,
      "y" : 191
    },
    "connectors" : [ {
      "edgeId" : 368,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1681,
          "y" : 186
        },
        "to" : {
          "x" : 1680,
          "y" : 138
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1674,
            "y" : 156
          },
          "b" : {
            "x" : 1686,
            "y" : 168
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1680,
            "y" : 162
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1677,
          "y" : 179
        },
        "b" : {
          "x" : 1681,
          "y" : 186
        },
        "c" : {
          "x" : 1685,
          "y" : 179
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1685,
          "y" : 179
        }
      }
    } ]
  }, {
    "id" : 373,
    "reactomeId" : 351626,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1680,
      "y" : 71
    },
    "isFadeOut" : true,
    "minX" : 1666,
    "maxX" : 1694,
    "minY" : 57,
    "maxY" : 139,
    "prop" : {
      "x" : 1666,
      "y" : 57,
      "width" : 28,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1666,
      "y" : 61
    },
    "connectors" : [ {
      "edgeId" : 368,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 1680,
          "y" : 89
        },
        "to" : {
          "x" : 1681,
          "y" : 139
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1674,
            "y" : 108
          },
          "b" : {
            "x" : 1686,
            "y" : 120
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1680,
            "y" : 114
          }
        }
      }
    } ]
  }, {
    "id" : 374,
    "reactomeId" : 9970133,
    "displayName" : "Cu1+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 265,
      "y" : 811
    },
    "isFadeOut" : true,
    "minX" : 243,
    "maxX" : 288,
    "minY" : 796,
    "maxY" : 827,
    "prop" : {
      "x" : 243,
      "y" : 796,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 244,
      "y" : 801
    },
    "connectors" : [ {
      "edgeId" : 6,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 375,
    "reactomeId" : 3299744,
    "displayName" : "Cu1+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 263,
      "y" : 672
    },
    "isFadeOut" : true,
    "minX" : 241,
    "maxX" : 286,
    "minY" : 657,
    "maxY" : 688,
    "prop" : {
      "x" : 241,
      "y" : 657,
      "width" : 45,
      "height" : 31
    },
    "textPosition" : {
      "x" : 242,
      "y" : 662
    },
    "connectors" : [ {
      "edgeId" : 6,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 247,
    "reactomeId" : 74722,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 675,
      "y" : 317
    },
    "isFadeOut" : true,
    "minX" : 659,
    "maxX" : 704,
    "minY" : 247,
    "maxY" : 333,
    "prop" : {
      "x" : 659,
      "y" : 302,
      "width" : 32,
      "height" : 31
    },
    "textPosition" : {
      "x" : 661,
      "y" : 307
    },
    "connectors" : [ {
      "edgeId" : 47,
      "type" : "INPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 681,
          "y" : 299
        },
        "to" : {
          "x" : 704,
          "y" : 247
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 686,
            "y" : 267
          },
          "b" : {
            "x" : 698,
            "y" : 279
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 692,
            "y" : 273
          }
        }
      }
    } ]
  }, {
    "id" : 249,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 772,
      "y" : 302
    },
    "isFadeOut" : true,
    "minX" : 705,
    "maxX" : 787,
    "minY" : 246,
    "maxY" : 315,
    "prop" : {
      "x" : 757,
      "y" : 289,
      "width" : 30,
      "height" : 26
    },
    "textPosition" : {
      "x" : 758,
      "y" : 291
    },
    "connectors" : [ {
      "edgeId" : 47,
      "type" : "OUTPUT",
      "isFadeOut" : true,
      "segments" : [ {
        "from" : {
          "x" : 754,
          "y" : 289
        },
        "to" : {
          "x" : 705,
          "y" : 246
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 723,
            "y" : 261
          },
          "b" : {
            "x" : 735,
            "y" : 273
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 729,
            "y" : 267
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 746,
          "y" : 287
        },
        "b" : {
          "x" : 754,
          "y" : 289
        },
        "c" : {
          "x" : 751,
          "y" : 281
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 751,
          "y" : 281
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 68,
    "reactomeId" : 9820566,
    "displayName" : "ZnT5 transports zinc into the golgi apparatus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1365,
      "y" : 372
    },
    "isFadeOut" : true,
    "minX" : 1210,
    "maxX" : 1371,
    "minY" : 265,
    "maxY" : 406,
    "segments" : [ {
      "from" : {
        "x" : 1210,
        "y" : 265
      },
      "to" : {
        "x" : 1365,
        "y" : 372
      }
    }, {
      "from" : {
        "x" : 1365,
        "y" : 372
      },
      "to" : {
        "x" : 1367,
        "y" : 406
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1363,
        "y" : 399
      },
      "b" : {
        "x" : 1367,
        "y" : 406
      },
      "c" : {
        "x" : 1371,
        "y" : 399
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1371,
        "y" : 399
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1359,
        "y" : 366
      },
      "b" : {
        "x" : 1371,
        "y" : 378
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1365,
        "y" : 372
      }
    },
    "inputs" : [ {
      "id" : 44
    } ],
    "outputs" : [ {
      "id" : 64
    } ],
    "catalysts" : [ {
      "id" : 69,
      "points" : [ {
        "x" : 1416,
        "y" : 372
      } ]
    } ]
  }, {
    "id" : 6,
    "reactomeId" : 437300,
    "displayName" : "SLC31A1 transports Cu1+ from extracellular region to cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 264,
      "y" : 754
    },
    "isFadeOut" : true,
    "minX" : 258,
    "maxX" : 270,
    "minY" : 691,
    "maxY" : 793,
    "segments" : [ {
      "from" : {
        "x" : 264,
        "y" : 793
      },
      "to" : {
        "x" : 264,
        "y" : 754
      }
    }, {
      "from" : {
        "x" : 264,
        "y" : 754
      },
      "to" : {
        "x" : 263,
        "y" : 691
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 267,
        "y" : 698
      },
      "b" : {
        "x" : 263,
        "y" : 691
      },
      "c" : {
        "x" : 259,
        "y" : 698
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 259,
        "y" : 698
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 258,
        "y" : 748
      },
      "b" : {
        "x" : 270,
        "y" : 760
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 264,
        "y" : 754
      }
    },
    "inputs" : [ {
      "id" : 374
    } ],
    "outputs" : [ {
      "id" : 375
    } ],
    "catalysts" : [ {
      "id" : 17,
      "points" : [ {
        "x" : 313,
        "y" : 752
      } ]
    } ]
  }, {
    "id" : 7,
    "reactomeId" : 442661,
    "displayName" : "SLC41A1,2 transport Mg2+ from extracellular region to cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 437,
      "y" : 751
    },
    "isFadeOut" : true,
    "minX" : 431,
    "maxX" : 443,
    "minY" : 700,
    "maxY" : 786,
    "segments" : [ {
      "from" : {
        "x" : 437,
        "y" : 786
      },
      "to" : {
        "x" : 437,
        "y" : 751
      }
    }, {
      "from" : {
        "x" : 437,
        "y" : 751
      },
      "to" : {
        "x" : 437,
        "y" : 700
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 441,
        "y" : 707
      },
      "b" : {
        "x" : 437,
        "y" : 700
      },
      "c" : {
        "x" : 433,
        "y" : 707
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 433,
        "y" : 707
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 431,
        "y" : 745
      },
      "b" : {
        "x" : 443,
        "y" : 757
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 437,
        "y" : 751
      }
    },
    "inputs" : [ {
      "id" : 3
    } ],
    "outputs" : [ {
      "id" : 21
    } ],
    "catalysts" : [ {
      "id" : 10,
      "points" : [ {
        "x" : 482,
        "y" : 752
      } ]
    } ]
  }, {
    "id" : 71,
    "reactomeId" : 442422,
    "displayName" : "SLC39A1-4 transports Zn2+ from extracellular region to cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1078,
      "y" : 138
    },
    "isFadeOut" : true,
    "minX" : 1072,
    "maxX" : 1173,
    "minY" : 38,
    "maxY" : 228,
    "segments" : [ {
      "from" : {
        "x" : 1164,
        "y" : 38
      },
      "to" : {
        "x" : 1078,
        "y" : 138
      }
    }, {
      "from" : {
        "x" : 1078,
        "y" : 138
      },
      "to" : {
        "x" : 1173,
        "y" : 228
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1165,
        "y" : 226
      },
      "b" : {
        "x" : 1173,
        "y" : 228
      },
      "c" : {
        "x" : 1171,
        "y" : 220
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1171,
        "y" : 220
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1072,
        "y" : 132
      },
      "b" : {
        "x" : 1084,
        "y" : 144
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1078,
        "y" : 138
      }
    },
    "inputs" : [ {
      "id" : 45
    } ],
    "outputs" : [ {
      "id" : 44
    } ],
    "catalysts" : [ {
      "id" : 72,
      "points" : [ {
        "x" : 1119,
        "y" : 138
      } ]
    } ]
  }, {
    "id" : 73,
    "reactomeId" : 442405,
    "displayName" : "hZIP5 mediates zinc uptake by cells",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1309,
      "y" : 140
    },
    "isFadeOut" : true,
    "minX" : 1194,
    "maxX" : 1315,
    "minY" : 38,
    "maxY" : 228,
    "segments" : [ {
      "from" : {
        "x" : 1194,
        "y" : 38
      },
      "to" : {
        "x" : 1309,
        "y" : 140
      }
    }, {
      "from" : {
        "x" : 1309,
        "y" : 140
      },
      "to" : {
        "x" : 1206,
        "y" : 228
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1209,
        "y" : 220
      },
      "b" : {
        "x" : 1206,
        "y" : 228
      },
      "c" : {
        "x" : 1214,
        "y" : 227
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1214,
        "y" : 227
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1303,
        "y" : 134
      },
      "b" : {
        "x" : 1315,
        "y" : 146
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1309,
        "y" : 140
      }
    },
    "inputs" : [ {
      "id" : 45
    } ],
    "outputs" : [ {
      "id" : 44
    } ],
    "catalysts" : [ {
      "id" : 74,
      "points" : [ {
        "x" : 1355,
        "y" : 138
      } ]
    } ]
  }, {
    "id" : 75,
    "reactomeId" : 442317,
    "displayName" : "ZIP6 and ZIP14 mediate zinc influx into cells",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1527,
      "y" : 141
    },
    "isFadeOut" : true,
    "minX" : 1204,
    "maxX" : 1533,
    "minY" : 26,
    "maxY" : 239,
    "segments" : [ {
      "from" : {
        "x" : 1204,
        "y" : 26
      },
      "to" : {
        "x" : 1527,
        "y" : 141
      }
    }, {
      "from" : {
        "x" : 1527,
        "y" : 141
      },
      "to" : {
        "x" : 1215,
        "y" : 239
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1220,
        "y" : 233
      },
      "b" : {
        "x" : 1215,
        "y" : 239
      },
      "c" : {
        "x" : 1223,
        "y" : 241
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1223,
        "y" : 241
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1521,
        "y" : 135
      },
      "b" : {
        "x" : 1533,
        "y" : 147
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1527,
        "y" : 141
      }
    },
    "inputs" : [ {
      "id" : 45
    } ],
    "outputs" : [ {
      "id" : 44
    } ],
    "catalysts" : [ {
      "id" : 76,
      "points" : [ {
        "x" : 1558,
        "y" : 140
      } ]
    } ]
  }, {
    "id" : 11,
    "reactomeId" : 435349,
    "displayName" : "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 249,
      "y" : 136
    },
    "isFadeOut" : true,
    "minX" : 243,
    "maxX" : 255,
    "minY" : 130,
    "maxY" : 142,
    "segments" : [ {
      "from" : {
        "x" : 251,
        "y" : 136
      },
      "to" : {
        "x" : 249,
        "y" : 136
      }
    }, {
      "from" : {
        "x" : 249,
        "y" : 136
      },
      "to" : {
        "x" : 251,
        "y" : 137
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 243,
        "y" : 130
      },
      "b" : {
        "x" : 255,
        "y" : 142
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 249,
        "y" : 136
      }
    },
    "inputs" : [ {
      "id" : 30,
      "points" : [ {
        "x" : 219,
        "y" : 104
      } ]
    }, {
      "id" : 12,
      "points" : [ {
        "x" : 280,
        "y" : 37
      } ]
    } ],
    "outputs" : [ {
      "id" : 29,
      "points" : [ {
        "x" : 310,
        "y" : 188
      } ]
    }, {
      "id" : 24,
      "points" : [ {
        "x" : 206,
        "y" : 213
      } ]
    } ],
    "catalysts" : [ {
      "id" : 23,
      "points" : [ {
        "x" : 209,
        "y" : 135
      } ]
    } ]
  }, {
    "id" : 13,
    "reactomeId" : 442368,
    "displayName" : "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 462,
      "y" : 137
    },
    "isFadeOut" : true,
    "minX" : 456,
    "maxX" : 485,
    "minY" : 38,
    "maxY" : 195,
    "segments" : [ {
      "from" : {
        "x" : 459,
        "y" : 195
      },
      "to" : {
        "x" : 462,
        "y" : 137
      }
    }, {
      "from" : {
        "x" : 462,
        "y" : 137
      },
      "to" : {
        "x" : 485,
        "y" : 38
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 487,
        "y" : 46
      },
      "b" : {
        "x" : 485,
        "y" : 38
      },
      "c" : {
        "x" : 480,
        "y" : 44
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 480,
        "y" : 44
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 456,
        "y" : 131
      },
      "b" : {
        "x" : 468,
        "y" : 143
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 462,
        "y" : 137
      }
    },
    "inputs" : [ {
      "id" : 39
    } ],
    "outputs" : [ {
      "id" : 37
    } ],
    "catalysts" : [ {
      "id" : 18,
      "points" : [ {
        "x" : 419,
        "y" : 137
      } ]
    } ]
  }, {
    "id" : 78,
    "reactomeId" : 442393,
    "displayName" : "ZIP7 mediates zinc efflux from the endoplasmic reticulum",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1461,
      "y" : 220
    },
    "isFadeOut" : true,
    "minX" : 1215,
    "maxX" : 1520,
    "minY" : 214,
    "maxY" : 243,
    "segments" : [ {
      "from" : {
        "x" : 1520,
        "y" : 236
      },
      "to" : {
        "x" : 1461,
        "y" : 220
      }
    }, {
      "from" : {
        "x" : 1461,
        "y" : 220
      },
      "to" : {
        "x" : 1215,
        "y" : 243
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1222,
        "y" : 238
      },
      "b" : {
        "x" : 1215,
        "y" : 243
      },
      "c" : {
        "x" : 1222,
        "y" : 246
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1222,
        "y" : 246
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1455,
        "y" : 214
      },
      "b" : {
        "x" : 1467,
        "y" : 226
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1461,
        "y" : 220
      }
    },
    "inputs" : [ {
      "id" : 79
    } ],
    "outputs" : [ {
      "id" : 44
    } ],
    "catalysts" : [ {
      "id" : 80,
      "points" : [ {
        "x" : 1468,
        "y" : 248
      } ]
    } ]
  }, {
    "id" : 15,
    "reactomeId" : 8959798,
    "displayName" : "SLC30A10 transports Mn2+ from cytosol to extracellular region",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 179,
      "y" : 752
    },
    "isFadeOut" : true,
    "minX" : 173,
    "maxX" : 185,
    "minY" : 746,
    "maxY" : 758,
    "segments" : [ {
      "from" : {
        "x" : 179,
        "y" : 751
      },
      "to" : {
        "x" : 179,
        "y" : 752
      }
    }, {
      "from" : {
        "x" : 179,
        "y" : 752
      },
      "to" : {
        "x" : 179,
        "y" : 753
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 173,
        "y" : 746
      },
      "b" : {
        "x" : 185,
        "y" : 758
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 179,
        "y" : 752
      }
    },
    "inputs" : [ {
      "id" : 4,
      "points" : [ {
        "x" : 179,
        "y" : 695
      } ]
    }, {
      "id" : 228,
      "points" : [ {
        "x" : 127,
        "y" : 783
      } ]
    } ],
    "outputs" : [ {
      "id" : 5,
      "points" : [ {
        "x" : 179,
        "y" : 790
      } ]
    }, {
      "id" : 229,
      "points" : [ {
        "x" : 130,
        "y" : 715
      } ]
    } ],
    "catalysts" : [ {
      "id" : 26,
      "points" : [ {
        "x" : 143,
        "y" : 752
      } ]
    } ]
  }, {
    "id" : 16,
    "reactomeId" : 904830,
    "displayName" : "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 528,
      "y" : 139
    },
    "isFadeOut" : true,
    "minX" : 473,
    "maxX" : 534,
    "minY" : 38,
    "maxY" : 195,
    "segments" : [ {
      "from" : {
        "x" : 473,
        "y" : 195
      },
      "to" : {
        "x" : 528,
        "y" : 139
      }
    }, {
      "from" : {
        "x" : 528,
        "y" : 139
      },
      "to" : {
        "x" : 494,
        "y" : 38
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 500,
        "y" : 43
      },
      "b" : {
        "x" : 494,
        "y" : 38
      },
      "c" : {
        "x" : 492,
        "y" : 46
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 492,
        "y" : 46
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 522,
        "y" : 133
      },
      "b" : {
        "x" : 534,
        "y" : 145
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 528,
        "y" : 139
      }
    },
    "inputs" : [ {
      "id" : 39
    } ],
    "outputs" : [ {
      "id" : 37
    } ],
    "catalysts" : [ {
      "id" : 19,
      "points" : [ {
        "x" : 573,
        "y" : 139
      } ]
    } ]
  }, {
    "id" : 337,
    "reactomeId" : 425994,
    "displayName" : "Na+/H+ exchanger transport (at cell membrane)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 846,
      "y" : 753
    },
    "isFadeOut" : true,
    "minX" : 840,
    "maxX" : 852,
    "minY" : 747,
    "maxY" : 759,
    "segments" : [ {
      "from" : {
        "x" : 845,
        "y" : 753
      },
      "to" : {
        "x" : 846,
        "y" : 753
      }
    }, {
      "from" : {
        "x" : 846,
        "y" : 753
      },
      "to" : {
        "x" : 843,
        "y" : 753
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 840,
        "y" : 747
      },
      "b" : {
        "x" : 852,
        "y" : 759
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 846,
        "y" : 753
      }
    },
    "inputs" : [ {
      "id" : 274,
      "points" : [ {
        "x" : 934,
        "y" : 807
      } ]
    }, {
      "id" : 344,
      "points" : [ {
        "x" : 836,
        "y" : 706
      } ]
    } ],
    "outputs" : [ {
      "id" : 275,
      "points" : [ {
        "x" : 927,
        "y" : 687
      } ]
    }, {
      "id" : 340,
      "points" : [ {
        "x" : 841,
        "y" : 801
      } ]
    } ],
    "catalysts" : [ {
      "id" : 338,
      "points" : [ {
        "x" : 780,
        "y" : 752
      } ]
    } ]
  }, {
    "id" : 81,
    "reactomeId" : 442387,
    "displayName" : "ZIP8 mediates zinc influx into cells",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 844,
      "y" : 134
    },
    "isFadeOut" : true,
    "minX" : 838,
    "maxX" : 850,
    "minY" : 128,
    "maxY" : 140,
    "segments" : [ {
      "from" : {
        "x" : 843,
        "y" : 135
      },
      "to" : {
        "x" : 844,
        "y" : 134
      }
    }, {
      "from" : {
        "x" : 844,
        "y" : 134
      },
      "to" : {
        "x" : 845,
        "y" : 135
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 838,
        "y" : 128
      },
      "b" : {
        "x" : 850,
        "y" : 140
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 844,
        "y" : 134
      }
    },
    "inputs" : [ {
      "id" : 272,
      "points" : [ {
        "x" : 844,
        "y" : 75
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 45,
      "points" : [ {
        "x" : 1153,
        "y" : 26
      } ]
    } ],
    "outputs" : [ {
      "id" : 271,
      "points" : [ {
        "x" : 846,
        "y" : 202
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 44,
      "points" : [ {
        "x" : 1164,
        "y" : 238
      } ]
    } ],
    "catalysts" : [ {
      "id" : 82,
      "points" : [ {
        "x" : 791,
        "y" : 134
      } ]
    } ]
  }, {
    "id" : 273,
    "reactomeId" : 425661,
    "displayName" : "SLC8A1,2,3 exchange 3Na+ for Ca2+",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1039,
      "y" : 753
    },
    "isFadeOut" : true,
    "minX" : 1033,
    "maxX" : 1045,
    "minY" : 747,
    "maxY" : 759,
    "segments" : [ {
      "from" : {
        "x" : 1040,
        "y" : 753
      },
      "to" : {
        "x" : 1039,
        "y" : 753
      }
    }, {
      "from" : {
        "x" : 1039,
        "y" : 753
      },
      "to" : {
        "x" : 1041,
        "y" : 753
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1033,
        "y" : 747
      },
      "b" : {
        "x" : 1045,
        "y" : 759
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1039,
        "y" : 753
      }
    },
    "inputs" : [ {
      "id" : 274,
      "points" : [ {
        "x" : 978,
        "y" : 804
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 280,
      "points" : [ {
        "x" : 1092,
        "y" : 693
      } ]
    } ],
    "outputs" : [ {
      "id" : 275,
      "points" : [ {
        "x" : 966,
        "y" : 692
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 282,
      "points" : [ {
        "x" : 1096,
        "y" : 804
      } ]
    } ],
    "catalysts" : [ {
      "id" : 276,
      "points" : [ {
        "x" : 985,
        "y" : 753
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 278,
      "points" : [ {
        "x" : 1004,
        "y" : 620
      } ]
    } ],
    "activators" : [ {
      "id" : 277,
      "points" : [ {
        "x" : 1048,
        "y" : 635
      } ]
    } ]
  }, {
    "id" : 84,
    "reactomeId" : 442345,
    "displayName" : "hZIP10 mediates zinc influx into cells",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 898,
      "y" : 136
    },
    "isFadeOut" : true,
    "minX" : 892,
    "maxX" : 1164,
    "minY" : 28,
    "maxY" : 237,
    "segments" : [ {
      "from" : {
        "x" : 1153,
        "y" : 28
      },
      "to" : {
        "x" : 898,
        "y" : 136
      }
    }, {
      "from" : {
        "x" : 898,
        "y" : 136
      },
      "to" : {
        "x" : 1164,
        "y" : 237
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1156,
        "y" : 238
      },
      "b" : {
        "x" : 1164,
        "y" : 237
      },
      "c" : {
        "x" : 1159,
        "y" : 231
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1159,
        "y" : 231
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 892,
        "y" : 130
      },
      "b" : {
        "x" : 904,
        "y" : 142
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 898,
        "y" : 136
      }
    },
    "inputs" : [ {
      "id" : 45
    } ],
    "outputs" : [ {
      "id" : 44
    } ],
    "catalysts" : [ {
      "id" : 85,
      "points" : [ {
        "x" : 948,
        "y" : 137
      } ]
    } ]
  }, {
    "id" : 25,
    "reactomeId" : 435171,
    "displayName" : "NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 177,
      "y" : 304
    },
    "isFadeOut" : true,
    "minX" : 171,
    "maxX" : 183,
    "minY" : 298,
    "maxY" : 310,
    "segments" : [ {
      "from" : {
        "x" : 178,
        "y" : 304
      },
      "to" : {
        "x" : 177,
        "y" : 304
      }
    }, {
      "from" : {
        "x" : 177,
        "y" : 304
      },
      "to" : {
        "x" : 178,
        "y" : 305
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 171,
        "y" : 298
      },
      "b" : {
        "x" : 183,
        "y" : 310
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 177,
        "y" : 304
      }
    },
    "inputs" : [ {
      "id" : 14,
      "points" : [ {
        "x" : 136,
        "y" : 277
      } ]
    }, {
      "id" : 28,
      "points" : [ {
        "x" : 235,
        "y" : 348
      } ]
    } ],
    "outputs" : [ {
      "id" : 22,
      "points" : [ {
        "x" : 159,
        "y" : 347
      } ]
    }, {
      "id" : 24,
      "points" : [ {
        "x" : 195,
        "y" : 245
      } ]
    } ],
    "catalysts" : [ {
      "id" : 27,
      "points" : [ {
        "x" : 218,
        "y" : 304
      } ]
    } ]
  }, {
    "id" : 345,
    "reactomeId" : 425983,
    "displayName" : "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 506,
      "y" : 442
    },
    "isFadeOut" : true,
    "minX" : 500,
    "maxX" : 512,
    "minY" : 436,
    "maxY" : 448,
    "segments" : [ {
      "from" : {
        "x" : 507,
        "y" : 443
      },
      "to" : {
        "x" : 506,
        "y" : 442
      }
    }, {
      "from" : {
        "x" : 506,
        "y" : 442
      },
      "to" : {
        "x" : 507,
        "y" : 444
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 500,
        "y" : 436
      },
      "b" : {
        "x" : 512,
        "y" : 448
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 506,
        "y" : 442
      }
    },
    "inputs" : [ {
      "id" : 346,
      "points" : [ {
        "x" : 418,
        "y" : 395
      } ]
    }, {
      "id" : 275,
      "points" : [ {
        "x" : 927,
        "y" : 663
      } ]
    } ],
    "outputs" : [ {
      "id" : 347,
      "points" : [ {
        "x" : 474,
        "y" : 385
      } ]
    }, {
      "id" : 353,
      "points" : [ {
        "x" : 568,
        "y" : 497
      } ]
    } ],
    "catalysts" : [ {
      "id" : 348,
      "points" : [ {
        "x" : 451,
        "y" : 442
      } ]
    } ]
  }, {
    "id" : 283,
    "reactomeId" : 425678,
    "displayName" : "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1185,
      "y" : 751
    },
    "isFadeOut" : true,
    "minX" : 1179,
    "maxX" : 1191,
    "minY" : 745,
    "maxY" : 757,
    "segments" : [ {
      "from" : {
        "x" : 1185,
        "y" : 754
      },
      "to" : {
        "x" : 1185,
        "y" : 751
      }
    }, {
      "from" : {
        "x" : 1185,
        "y" : 751
      },
      "to" : {
        "x" : 1187,
        "y" : 751
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1179,
        "y" : 745
      },
      "b" : {
        "x" : 1191,
        "y" : 757
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1185,
        "y" : 751
      }
    },
    "inputs" : [ {
      "id" : 284,
      "points" : [ {
        "x" : 1243,
        "y" : 694
      } ]
    }, {
      "id" : 280,
      "points" : [ {
        "x" : 1120,
        "y" : 693
      } ]
    }, {
      "id" : 299,
      "points" : [ {
        "x" : 1186,
        "y" : 801
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 285,
      "points" : [ {
        "x" : 1245,
        "y" : 808
      } ]
    }, {
      "id" : 282,
      "points" : [ {
        "x" : 1129,
        "y" : 804
      } ]
    }, {
      "id" : 297,
      "points" : [ {
        "x" : 1184,
        "y" : 694
      } ],
      "stoichiometry" : 4
    } ],
    "catalysts" : [ {
      "id" : 286,
      "points" : [ {
        "x" : 1251,
        "y" : 753
      } ]
    } ]
  }, {
    "id" : 354,
    "reactomeId" : 426015,
    "displayName" : "Na+/H+ exchanger transport (at trans-golgi membrane)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1570,
      "y" : 579
    },
    "isFadeOut" : true,
    "minX" : 1564,
    "maxX" : 1576,
    "minY" : 573,
    "maxY" : 585,
    "segments" : [ {
      "from" : {
        "x" : 1567,
        "y" : 577
      },
      "to" : {
        "x" : 1570,
        "y" : 579
      }
    }, {
      "from" : {
        "x" : 1570,
        "y" : 579
      },
      "to" : {
        "x" : 1568,
        "y" : 576
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1564,
        "y" : 573
      },
      "b" : {
        "x" : 1576,
        "y" : 585
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1570,
        "y" : 579
      }
    },
    "inputs" : [ {
      "id" : 262,
      "points" : [ {
        "x" : 1508,
        "y" : 499
      } ]
    }, {
      "id" : 360,
      "points" : [ {
        "x" : 1556,
        "y" : 643
      } ]
    } ],
    "outputs" : [ {
      "id" : 303,
      "points" : [ {
        "x" : 1436,
        "y" : 510
      } ]
    }, {
      "id" : 359,
      "points" : [ {
        "x" : 1612,
        "y" : 614
      } ]
    } ],
    "catalysts" : [ {
      "id" : 355,
      "points" : [ {
        "x" : 1613,
        "y" : 566
      } ]
    } ]
  }, {
    "id" : 363,
    "reactomeId" : 425965,
    "displayName" : "SLC9A9 exchanges Na+ for H+ across the late endosome membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 518,
      "y" : 554
    },
    "isFadeOut" : true,
    "minX" : 512,
    "maxX" : 524,
    "minY" : 548,
    "maxY" : 560,
    "segments" : [ {
      "from" : {
        "x" : 516,
        "y" : 553
      },
      "to" : {
        "x" : 518,
        "y" : 554
      }
    }, {
      "from" : {
        "x" : 518,
        "y" : 554
      },
      "to" : {
        "x" : 518,
        "y" : 553
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 512,
        "y" : 548
      },
      "b" : {
        "x" : 524,
        "y" : 560
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 518,
        "y" : 554
      }
    },
    "inputs" : [ {
      "id" : 364,
      "points" : [ {
        "x" : 409,
        "y" : 572
      } ]
    }, {
      "id" : 275,
      "points" : [ {
        "x" : 927,
        "y" : 667
      } ]
    } ],
    "outputs" : [ {
      "id" : 365,
      "points" : [ {
        "x" : 460,
        "y" : 537
      } ]
    }, {
      "id" : 353,
      "points" : [ {
        "x" : 565,
        "y" : 522
      } ]
    } ],
    "catalysts" : [ {
      "id" : 366,
      "points" : [ {
        "x" : 503,
        "y" : 594
      } ]
    } ]
  }, {
    "id" : 300,
    "reactomeId" : 5626316,
    "displayName" : "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1324,
      "y" : 580
    },
    "isFadeOut" : true,
    "minX" : 1318,
    "maxX" : 1330,
    "minY" : 574,
    "maxY" : 586,
    "segments" : [ {
      "from" : {
        "x" : 1324,
        "y" : 581
      },
      "to" : {
        "x" : 1324,
        "y" : 580
      }
    }, {
      "from" : {
        "x" : 1324,
        "y" : 580
      },
      "to" : {
        "x" : 1324,
        "y" : 578
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1318,
        "y" : 574
      },
      "b" : {
        "x" : 1330,
        "y" : 586
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1324,
        "y" : 580
      }
    },
    "inputs" : [ {
      "id" : 301,
      "points" : [ {
        "x" : 1300,
        "y" : 521
      } ]
    }, {
      "id" : 302,
      "points" : [ {
        "x" : 1345,
        "y" : 518
      } ]
    }, {
      "id" : 297,
      "points" : [ {
        "x" : 1206,
        "y" : 662
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 284,
      "points" : [ {
        "x" : 1268,
        "y" : 657
      } ]
    }, {
      "id" : 303,
      "points" : [ {
        "x" : 1395,
        "y" : 520
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 318,
      "points" : [ {
        "x" : 1378,
        "y" : 654
      } ]
    } ],
    "catalysts" : [ {
      "id" : 304,
      "points" : [ {
        "x" : 1373,
        "y" : 579
      } ]
    } ]
  }, {
    "id" : 142767,
    "reactomeId" : 5661086,
    "displayName" : "Defective SLC9A9 does not exchange Na+ for H+ across the late endosome membrane",
    "schemaClass" : "FailedReaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 518,
      "y" : 554
    },
    "isDisease" : true,
    "minX" : 512,
    "maxX" : 524,
    "minY" : 548,
    "maxY" : 560,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 516,
        "y" : 553
      },
      "to" : {
        "x" : 518,
        "y" : 554
      }
    }, {
      "from" : {
        "x" : 518,
        "y" : 554
      },
      "to" : {
        "x" : 518,
        "y" : 553
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 512,
        "y" : 548
      },
      "b" : {
        "x" : 524,
        "y" : 560
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 518,
        "y" : 554
      }
    },
    "inputs" : [ {
      "id" : 364,
      "points" : [ {
        "x" : 409,
        "y" : 572
      } ]
    }, {
      "id" : 275,
      "points" : [ {
        "x" : 927,
        "y" : 667
      } ]
    } ],
    "outputs" : [ {
      "id" : 365,
      "points" : [ {
        "x" : 460,
        "y" : 537
      } ]
    }, {
      "id" : 353,
      "points" : [ {
        "x" : 565,
        "y" : 522
      } ]
    } ],
    "catalysts" : [ {
      "id" : 142768,
      "points" : [ {
        "x" : 503,
        "y" : 594
      } ]
    } ]
  }, {
    "id" : 47,
    "reactomeId" : 435375,
    "displayName" : "ZnT2 facilitates zinc vesicular sequestration",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 704,
      "y" : 246
    },
    "isFadeOut" : true,
    "minX" : 698,
    "maxX" : 710,
    "minY" : 240,
    "maxY" : 252,
    "segments" : [ {
      "from" : {
        "x" : 704,
        "y" : 247
      },
      "to" : {
        "x" : 704,
        "y" : 246
      }
    }, {
      "from" : {
        "x" : 704,
        "y" : 246
      },
      "to" : {
        "x" : 705,
        "y" : 246
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 698,
        "y" : 240
      },
      "b" : {
        "x" : 710,
        "y" : 252
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 704,
        "y" : 246
      }
    },
    "inputs" : [ {
      "id" : 247,
      "points" : [ {
        "x" : 681,
        "y" : 299
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 44,
      "points" : [ {
        "x" : 1164,
        "y" : 246
      } ]
    } ],
    "outputs" : [ {
      "id" : 48,
      "points" : [ {
        "x" : 648,
        "y" : 274
      } ]
    }, {
      "id" : 249,
      "points" : [ {
        "x" : 754,
        "y" : 289
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 49,
      "points" : [ {
        "x" : 650,
        "y" : 233
      } ]
    } ]
  }, {
    "id" : 368,
    "reactomeId" : 435366,
    "displayName" : "ZnT1 mediates the efflux of zinc from the cell",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1680,
      "y" : 138
    },
    "isFadeOut" : true,
    "minX" : 1674,
    "maxX" : 1686,
    "minY" : 132,
    "maxY" : 144,
    "segments" : [ {
      "from" : {
        "x" : 1681,
        "y" : 139
      },
      "to" : {
        "x" : 1680,
        "y" : 138
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1674,
        "y" : 132
      },
      "b" : {
        "x" : 1686,
        "y" : 144
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1680,
        "y" : 138
      }
    },
    "inputs" : [ {
      "id" : 44,
      "points" : [ {
        "x" : 1215,
        "y" : 242
      }, {
        "x" : 1626,
        "y" : 176
      } ]
    }, {
      "id" : 373,
      "points" : [ {
        "x" : 1680,
        "y" : 89
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 45,
      "points" : [ {
        "x" : 1204,
        "y" : 22
      }, {
        "x" : 1622,
        "y" : 90
      } ]
    }, {
      "id" : 371,
      "points" : [ {
        "x" : 1681,
        "y" : 186
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 369,
      "points" : [ {
        "x" : 1714,
        "y" : 137
      } ]
    } ]
  }, {
    "id" : 52,
    "reactomeId" : 437084,
    "displayName" : "ZnT3 transports zinc into synaptic vesicles",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 888,
      "y" : 357
    },
    "isFadeOut" : true,
    "minX" : 882,
    "maxX" : 1164,
    "minY" : 254,
    "maxY" : 402,
    "segments" : [ {
      "from" : {
        "x" : 1164,
        "y" : 254
      },
      "to" : {
        "x" : 888,
        "y" : 357
      }
    }, {
      "from" : {
        "x" : 888,
        "y" : 357
      },
      "to" : {
        "x" : 888,
        "y" : 402
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 884,
        "y" : 395
      },
      "b" : {
        "x" : 888,
        "y" : 402
      },
      "c" : {
        "x" : 892,
        "y" : 395
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 892,
        "y" : 395
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 882,
        "y" : 351
      },
      "b" : {
        "x" : 894,
        "y" : 363
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 888,
        "y" : 357
      }
    },
    "inputs" : [ {
      "id" : 44
    } ],
    "outputs" : [ {
      "id" : 53
    } ],
    "catalysts" : [ {
      "id" : 54,
      "points" : [ {
        "x" : 830,
        "y" : 356
      } ]
    } ]
  }, {
    "id" : 56,
    "reactomeId" : 437085,
    "displayName" : "ZnT5 transports zinc into secretory granules in pancreatic beta cells",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1097,
      "y" : 364
    },
    "isFadeOut" : true,
    "minX" : 1091,
    "maxX" : 1176,
    "minY" : 265,
    "maxY" : 394,
    "segments" : [ {
      "from" : {
        "x" : 1176,
        "y" : 265
      },
      "to" : {
        "x" : 1097,
        "y" : 364
      }
    }, {
      "from" : {
        "x" : 1097,
        "y" : 364
      },
      "to" : {
        "x" : 1098,
        "y" : 394
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1094,
        "y" : 387
      },
      "b" : {
        "x" : 1098,
        "y" : 394
      },
      "c" : {
        "x" : 1102,
        "y" : 387
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1102,
        "y" : 387
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1091,
        "y" : 358
      },
      "b" : {
        "x" : 1103,
        "y" : 370
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1097,
        "y" : 364
      }
    },
    "inputs" : [ {
      "id" : 44
    } ],
    "outputs" : [ {
      "id" : 57
    } ],
    "catalysts" : [ {
      "id" : 58,
      "points" : [ {
        "x" : 1056,
        "y" : 365
      } ]
    } ]
  }, {
    "id" : 61,
    "reactomeId" : 437136,
    "displayName" : "SLC30A8 transports Zn2+ from cytosol to secretory granule",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1143,
      "y" : 358
    },
    "isFadeOut" : true,
    "minX" : 1137,
    "maxX" : 1149,
    "minY" : 352,
    "maxY" : 364,
    "segments" : [ {
      "from" : {
        "x" : 1141,
        "y" : 359
      },
      "to" : {
        "x" : 1143,
        "y" : 358
      }
    }, {
      "from" : {
        "x" : 1143,
        "y" : 358
      },
      "to" : {
        "x" : 1144,
        "y" : 360
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1137,
        "y" : 352
      },
      "b" : {
        "x" : 1149,
        "y" : 364
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1143,
        "y" : 358
      }
    },
    "inputs" : [ {
      "id" : 44,
      "points" : [ {
        "x" : 1182,
        "y" : 265
      } ]
    }, {
      "id" : 267,
      "points" : [ {
        "x" : 1153,
        "y" : 405
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 57,
      "points" : [ {
        "x" : 1112,
        "y" : 394
      } ]
    }, {
      "id" : 265,
      "points" : [ {
        "x" : 1198,
        "y" : 329
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 62,
      "points" : [ {
        "x" : 1191,
        "y" : 383
      } ]
    } ]
  }, {
    "id" : 63,
    "reactomeId" : 437139,
    "displayName" : "ZnT8 transports zinc into the Golgi apparatus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1323,
      "y" : 373
    },
    "isFadeOut" : true,
    "minX" : 1317,
    "maxX" : 1329,
    "minY" : 367,
    "maxY" : 379,
    "segments" : [ {
      "from" : {
        "x" : 1324,
        "y" : 374
      },
      "to" : {
        "x" : 1323,
        "y" : 373
      }
    }, {
      "from" : {
        "x" : 1323,
        "y" : 373
      },
      "to" : {
        "x" : 1325,
        "y" : 374
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1317,
        "y" : 367
      },
      "b" : {
        "x" : 1329,
        "y" : 379
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1323,
        "y" : 373
      }
    },
    "inputs" : [ {
      "id" : 44,
      "points" : [ {
        "x" : 1205,
        "y" : 265
      } ]
    }, {
      "id" : 262,
      "points" : [ {
        "x" : 1479,
        "y" : 477
      }, {
        "x" : 1334,
        "y" : 456
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 64,
      "points" : [ {
        "x" : 1354,
        "y" : 406
      } ]
    }, {
      "id" : 265,
      "points" : [ {
        "x" : 1234,
        "y" : 329
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 65,
      "points" : [ {
        "x" : 1302,
        "y" : 392
      } ]
    } ]
  }, {
    "id" : 319,
    "reactomeId" : 425822,
    "displayName" : "K+-independent Li+/Ca2+ exchanger transport",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1461,
      "y" : 753
    },
    "isFadeOut" : true,
    "minX" : 1455,
    "maxX" : 1467,
    "minY" : 747,
    "maxY" : 759,
    "segments" : [ {
      "from" : {
        "x" : 1462,
        "y" : 752
      },
      "to" : {
        "x" : 1461,
        "y" : 753
      }
    }, {
      "from" : {
        "x" : 1461,
        "y" : 753
      },
      "to" : {
        "x" : 1463,
        "y" : 752
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1455,
        "y" : 747
      },
      "b" : {
        "x" : 1467,
        "y" : 759
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1461,
        "y" : 753
      }
    },
    "inputs" : [ {
      "id" : 320,
      "points" : [ {
        "x" : 1405,
        "y" : 804
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 318,
      "points" : [ {
        "x" : 1403,
        "y" : 691
      } ]
    } ],
    "outputs" : [ {
      "id" : 321,
      "points" : [ {
        "x" : 1482,
        "y" : 696
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 334,
      "points" : [ {
        "x" : 1473,
        "y" : 804
      } ]
    } ],
    "catalysts" : [ {
      "id" : 322,
      "points" : [ {
        "x" : 1424,
        "y" : 753
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 32,
    "reactomeId" : 1222282,
    "displayName" : "phagocytic vesicle lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 188,
      "y" : 391
    },
    "minX" : 48,
    "maxX" : 328,
    "minY" : 300,
    "maxY" : 482,
    "prop" : {
      "x" : 48,
      "y" : 300,
      "width" : 280,
      "height" : 182
    },
    "textPosition" : {
      "x" : 138,
      "y" : 438
    },
    "insets" : {
      "x" : 58,
      "y" : 310,
      "width" : 261,
      "height" : 165
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 27, 28, 22, 25 ]
  }, {
    "id" : 50,
    "reactomeId" : 171907,
    "displayName" : "endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 623,
      "y" : 303
    },
    "minX" : 536,
    "maxX" : 711,
    "minY" : 219,
    "maxY" : 388,
    "prop" : {
      "x" : 536,
      "y" : 219,
      "width" : 175,
      "height" : 169
    },
    "textPosition" : {
      "x" : 569,
      "y" : 336
    },
    "insets" : {
      "x" : 547,
      "y" : 229,
      "width" : 155,
      "height" : 150
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 48, 47, 49, 247 ]
  }, {
    "id" : 66,
    "reactomeId" : 17963,
    "displayName" : "Golgi lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1449,
      "y" : 475
    },
    "minX" : 1257,
    "maxX" : 1642,
    "minY" : 366,
    "maxY" : 584,
    "prop" : {
      "x" : 1257,
      "y" : 366,
      "width" : 385,
      "height" : 218
    },
    "textPosition" : {
      "x" : 1407,
      "y" : 409
    },
    "insets" : {
      "x" : 1265,
      "y" : 373,
      "width" : 368,
      "height" : 203
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 64, 65, 63, 69, 68, 262, 301, 302, 303, 304, 300, 355, 354 ]
  }, {
    "id" : 87,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1540,
      "y" : 274
    },
    "minX" : 1457,
    "maxX" : 1623,
    "minY" : 211,
    "maxY" : 338,
    "prop" : {
      "x" : 1457,
      "y" : 211,
      "width" : 166,
      "height" : 127
    },
    "textPosition" : {
      "x" : 1466,
      "y" : 278
    },
    "insets" : {
      "x" : 1465,
      "y" : 216,
      "width" : 151,
      "height" : 113
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 80, 78, 79 ]
  }, {
    "id" : 55,
    "reactomeId" : 20600,
    "displayName" : "synaptic vesicle",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 846,
      "y" : 425
    },
    "minX" : 721,
    "maxX" : 971,
    "minY" : 351,
    "maxY" : 499,
    "prop" : {
      "x" : 721,
      "y" : 351,
      "width" : 250,
      "height" : 148
    },
    "textPosition" : {
      "x" : 748,
      "y" : 441
    },
    "insets" : {
      "x" : 731,
      "y" : 361,
      "width" : 230,
      "height" : 128
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 53, 54, 52 ]
  }, {
    "id" : 59,
    "reactomeId" : 1462052,
    "displayName" : "secretory granule lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1108,
      "y" : 427
    },
    "minX" : 1001,
    "maxX" : 1215,
    "minY" : 356,
    "maxY" : 499,
    "prop" : {
      "x" : 1001,
      "y" : 356,
      "width" : 214,
      "height" : 143
    },
    "textPosition" : {
      "x" : 1045,
      "y" : 444
    },
    "insets" : {
      "x" : 1009,
      "y" : 366,
      "width" : 198,
      "height" : 126
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 58, 56, 57, 61, 62, 267 ]
  }, {
    "id" : 349,
    "reactomeId" : 171043,
    "displayName" : "early endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 432,
      "y" : 368
    },
    "minX" : 345,
    "maxX" : 520,
    "minY" : 285,
    "maxY" : 451,
    "prop" : {
      "x" : 345,
      "y" : 285,
      "width" : 175,
      "height" : 166
    },
    "textPosition" : {
      "x" : 363,
      "y" : 298
    },
    "insets" : {
      "x" : 360,
      "y" : 295,
      "width" : 150,
      "height" : 146
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 348, 346, 347, 345 ]
  }, {
    "id" : 31,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 887,
      "y" : 445
    },
    "minX" : 0,
    "maxX" : 1775,
    "minY" : 132,
    "maxY" : 759,
    "prop" : {
      "x" : 0,
      "y" : 132,
      "width" : 1775,
      "height" : 627
    },
    "textPosition" : {
      "x" : 436,
      "y" : 249
    },
    "insets" : {
      "x" : 10,
      "y" : 142,
      "width" : 1752,
      "height" : 601
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 6, 10, 15, 17, 21, 23, 26, 32, 24, 14, 11, 13, 18, 16, 4, 7, 44, 50, 55, 59, 66, 71, 72, 73, 74, 76, 75, 81, 82, 85, 84, 87, 19, 229, 249, 265, 271, 273, 275, 276, 280, 278, 277, 286, 284, 297, 283, 318, 321, 322, 319, 338, 337, 344, 349, 29, 39, 360, 359, 367, 353, 369, 368, 371, 375 ]
  }, {
    "id" : 367,
    "reactomeId" : 173031,
    "displayName" : "late endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 432,
      "y" : 547
    },
    "minX" : 342,
    "maxX" : 523,
    "minY" : 477,
    "maxY" : 618,
    "prop" : {
      "x" : 342,
      "y" : 477,
      "width" : 181,
      "height" : 141
    },
    "textPosition" : {
      "x" : 363,
      "y" : 491
    },
    "insets" : {
      "x" : 352,
      "y" : 488,
      "width" : 162,
      "height" : 122
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 366, 363, 364, 365 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1776,
  "minY" : 0,
  "maxY" : 839,
  "disease" : true
}