{
  "dbId" : 4655427,
  "stId" : "R-HSA-4655427",
  "speciesName" : "Homo sapiens",
  "nodes" : [ {
    "dbId" : 3730617,
    "stId" : "R-HSA-3730617",
    "displayName" : "SUMO1-C93-UBE2I [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P63279",
    "standardIdentifier" : "uniprot:P63279",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBE2I", "UBC9", "UBCE9" ],
    "parents" : [ 2993783 ],
    "children" : [ ]
  }, {
    "dbId" : 389121,
    "stId" : "R-HSA-389121",
    "displayName" : "BMI1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P35226",
    "standardIdentifier" : "uniprot:P35226",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "BMI1", "PCGF4", "RNF51" ],
    "parents" : [ 9007663 ],
    "children" : [ ]
  }, {
    "dbId" : 3730622,
    "stId" : "R-HSA-3730622",
    "displayName" : "UBE2I-G97-SUMO1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P63165",
    "standardIdentifier" : "uniprot:P63165",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SUMO1", "SMT3C", "SMT3H3", "UBL1", "OK/SW-cl.43" ],
    "parents" : [ 2993783 ],
    "children" : [ ]
  }, {
    "dbId" : 389122,
    "stId" : "R-HSA-389122",
    "displayName" : "SCMH1-2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q96GD3-2",
    "standardIdentifier" : "uniprot:Q96GD3-2",
    "referenceType" : "ReferenceIsoform",
    "geneNames" : [ "SCMH1" ],
    "parents" : [ 389114 ],
    "children" : [ ]
  }, {
    "dbId" : 212181,
    "stId" : "R-HSA-212181",
    "displayName" : "DNMT1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 4 ],
    "identifier" : "P26358",
    "standardIdentifier" : "uniprot:P26358",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "DNMT1", "AIM", "CXXC9", "DNMT" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 2993783,
    "stId" : "R-HSA-2993783",
    "displayName" : "SUMO1:C93-UBE2I [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 18, 3, 12 ],
    "parents" : [ ],
    "children" : [ 3730617, 3730622 ]
  }, {
    "dbId" : 212316,
    "stId" : "R-HSA-212316",
    "displayName" : "DNMT3B [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 16 ],
    "identifier" : "Q9UBC3",
    "standardIdentifier" : "uniprot:Q9UBC3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "DNMT3B" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 4655334,
    "stId" : "R-HSA-4655334",
    "displayName" : "SUMO1-K-DNMT3B [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 22 ],
    "identifier" : "Q9UBC3",
    "standardIdentifier" : "uniprot:Q9UBC3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "DNMT3B" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 9007663,
    "stId" : "R-HSA-9007663",
    "displayName" : "BMI1,PCGF2 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "parents" : [ 389114 ],
    "children" : [ 389115, 389121 ]
  }, {
    "dbId" : 9007201,
    "stId" : "R-HSA-9007201",
    "displayName" : "RING1,RNF2 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "parents" : [ 389114 ],
    "children" : [ 389113, 389119 ]
  }, {
    "dbId" : 9007200,
    "stId" : "R-HSA-9007200",
    "displayName" : "PHC1,PHC2,PHC3 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "parents" : [ 389114 ],
    "children" : [ 389112, 389116, 389111 ]
  }, {
    "dbId" : 912481,
    "stId" : "R-HSA-912481",
    "displayName" : "UBE2I [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 19, 6, 14 ],
    "identifier" : "P63279",
    "standardIdentifier" : "uniprot:P63279",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "UBE2I", "UBC9", "UBCE9" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 4655415,
    "stId" : "R-HSA-4655415",
    "displayName" : "monoSUMO1-K-DNMT3A [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 21 ],
    "identifier" : "Q9Y6K1",
    "standardIdentifier" : "uniprot:Q9Y6K1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "DNMT3A" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 389111,
    "stId" : "R-HSA-389111",
    "displayName" : "PHC1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P78364",
    "standardIdentifier" : "uniprot:P78364",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PHC1", "EDR1", "PH1" ],
    "parents" : [ 9007200 ],
    "children" : [ ]
  }, {
    "dbId" : 389110,
    "stId" : "R-HSA-389110",
    "displayName" : "CBX2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q14781",
    "standardIdentifier" : "uniprot:Q14781",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CBX2" ],
    "parents" : [ 9007665 ],
    "children" : [ ]
  }, {
    "dbId" : 9007665,
    "stId" : "R-HSA-9007665",
    "displayName" : "CBX2,CBX4,CBX8 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "parents" : [ 389114 ],
    "children" : [ 389118, 389117, 389110 ]
  }, {
    "dbId" : 389117,
    "stId" : "R-HSA-389117",
    "displayName" : "CBX8 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q9HC52",
    "standardIdentifier" : "uniprot:Q9HC52",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CBX8", "PC3", "RC1" ],
    "parents" : [ 9007665 ],
    "children" : [ ]
  }, {
    "dbId" : 389116,
    "stId" : "R-HSA-389116",
    "displayName" : "PHC3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q8NDX5",
    "standardIdentifier" : "uniprot:Q8NDX5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PHC3", "EDR3", "PH3" ],
    "parents" : [ 9007200 ],
    "children" : [ ]
  }, {
    "dbId" : 389119,
    "stId" : "R-HSA-389119",
    "displayName" : "RNF2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q99496",
    "standardIdentifier" : "uniprot:Q99496",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RNF2", "BAP1", "DING", "HIPI3", "RING1B" ],
    "parents" : [ 9007201 ],
    "children" : [ ]
  }, {
    "dbId" : 389118,
    "stId" : "R-HSA-389118",
    "displayName" : "CBX4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "O00257",
    "standardIdentifier" : "uniprot:O00257",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "CBX4" ],
    "parents" : [ 9007665 ],
    "children" : [ ]
  }, {
    "dbId" : 389113,
    "stId" : "R-HSA-389113",
    "displayName" : "RING1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q06587",
    "standardIdentifier" : "uniprot:Q06587",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "RING1", "RING1A", "RNF1" ],
    "parents" : [ 9007201 ],
    "children" : [ ]
  }, {
    "dbId" : 212287,
    "stId" : "R-HSA-212287",
    "displayName" : "DNMT3A [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 8 ],
    "identifier" : "Q9Y6K1",
    "standardIdentifier" : "uniprot:Q9Y6K1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "DNMT3A" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 389112,
    "stId" : "R-HSA-389112",
    "displayName" : "PHC2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "Q8IXK0",
    "standardIdentifier" : "uniprot:Q8IXK0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PHC2", "EDR2", "PH2" ],
    "parents" : [ 9007200 ],
    "children" : [ ]
  }, {
    "dbId" : 4655353,
    "stId" : "R-HSA-4655353",
    "displayName" : "monoSUMO1-K-DNMT1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 20 ],
    "identifier" : "P26358",
    "standardIdentifier" : "uniprot:P26358",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "DNMT1", "AIM", "CXXC9", "DNMT" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 389115,
    "stId" : "R-HSA-389115",
    "displayName" : "PCGF2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P35227",
    "standardIdentifier" : "uniprot:P35227",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "PCGF2", "MEL18", "RNF110", "ZNF144" ],
    "parents" : [ 9007663 ],
    "children" : [ ]
  }, {
    "dbId" : 389114,
    "stId" : "R-HSA-389114",
    "displayName" : "PRC1 complex [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 10 ],
    "parents" : [ ],
    "children" : [ 9007200, 9007665, 9007201, 389122, 9007663 ]
  } ],
  "edges" : [ {
    "dbId" : 4655431,
    "stId" : "R-HSA-4655431",
    "displayName" : "SUMOyation of DNMT1 with SUMO1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 2993783, 212181 ],
    "outputs" : [ 4655353, 912481 ],
    "catalysts" : [ 2993783 ],
    "efs" : [ ],
    "diagramIds" : [ 2 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 4655440,
    "stId" : "R-HSA-4655440",
    "displayName" : "CBX4 (Pc2) SUMOylates DNMT3A with SUMO1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 212287, 2993783 ],
    "outputs" : [ 912481, 4655415 ],
    "catalysts" : [ 389114 ],
    "efs" : [ ],
    "diagramIds" : [ 7 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 4655374,
    "stId" : "R-HSA-4655374",
    "displayName" : "SUMOylation of DNMT3B with SUMO1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 212316, 2993783 ],
    "outputs" : [ 912481, 4655334 ],
    "catalysts" : [ 2993783 ],
    "efs" : [ ],
    "diagramIds" : [ 15 ],
    "entityFunctionalStatus" : [ ]
  } ]
}