{
  "dbId" : 381183,
  "stableId" : "R-HSA-381183",
  "displayName" : "ATF6 (ATF6-alpha) activates chaperone genes",
  "nodes" : [ {
    "id" : 5,
    "reactomeId" : 351315,
    "displayName" : "HSPA5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 268,
      "y" : 416
    },
    "minX" : 235,
    "maxX" : 307,
    "minY" : 398,
    "maxY" : 428,
    "prop" : {
      "x" : 235,
      "y" : 404,
      "width" : 66,
      "height" : 24
    },
    "textPosition" : {
      "x" : 243,
      "y" : 405
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 301,
          "y" : 404
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 301,
          "y" : 404
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 4,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 6,
    "reactomeId" : 381016,
    "displayName" : "ATF4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 255,
      "y" : 197
    },
    "minX" : 201,
    "maxX" : 294,
    "minY" : 153,
    "maxY" : 283,
    "prop" : {
      "x" : 223,
      "y" : 185,
      "width" : 65,
      "height" : 24
    },
    "textPosition" : {
      "x" : 236,
      "y" : 186
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 288,
          "y" : 185
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 288,
          "y" : 185
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 4,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 256,
          "y" : 212
        },
        "to" : {
          "x" : 264,
          "y" : 283
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 259,
          "y" : 277
        },
        "b" : {
          "x" : 264,
          "y" : 283
        },
        "c" : {
          "x" : 267,
          "y" : 276
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 267,
          "y" : 276
        }
      }
    }, {
      "edgeId" : 9,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 240,
          "y" : 182
        },
        "to" : {
          "x" : 201,
          "y" : 153
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 209,
          "y" : 154
        },
        "b" : {
          "x" : 201,
          "y" : 153
        },
        "c" : {
          "x" : 204,
          "y" : 160
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 204,
          "y" : 160
        }
      }
    } ]
  }, {
    "id" : 7,
    "reactomeId" : 381211,
    "displayName" : "ATF6(1-380)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 387,
      "y" : 53
    },
    "minX" : 202,
    "maxX" : 649,
    "minY" : 34,
    "maxY" : 302,
    "prop" : {
      "x" : 340,
      "y" : 40,
      "width" : 95,
      "height" : 26
    },
    "textPosition" : {
      "x" : 345,
      "y" : 42
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 435,
          "y" : 40
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 435,
          "y" : 40
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 4,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 380,
          "y" : 69
        },
        "to" : {
          "x" : 269,
          "y" : 284
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 269,
          "y" : 276
        },
        "b" : {
          "x" : 269,
          "y" : 284
        },
        "c" : {
          "x" : 276,
          "y" : 280
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 276,
          "y" : 280
        }
      }
    }, {
      "edgeId" : 20,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 438,
          "y" : 65
        },
        "to" : {
          "x" : 646,
          "y" : 122
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 638,
          "y" : 124
        },
        "b" : {
          "x" : 646,
          "y" : 122
        },
        "c" : {
          "x" : 640,
          "y" : 116
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 640,
          "y" : 116
        }
      }
    }, {
      "edgeId" : 9,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 360,
          "y" : 69
        },
        "to" : {
          "x" : 202,
          "y" : 144
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 207,
          "y" : 137
        },
        "b" : {
          "x" : 202,
          "y" : 144
        },
        "c" : {
          "x" : 210,
          "y" : 145
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 210,
          "y" : 145
        }
      }
    }, {
      "edgeId" : 11,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 389,
          "y" : 69
        },
        "to" : {
          "x" : 429,
          "y" : 302
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 424,
          "y" : 296
        },
        "b" : {
          "x" : 429,
          "y" : 302
        },
        "c" : {
          "x" : 432,
          "y" : 294
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 432,
          "y" : 294
        }
      }
    }, {
      "edgeId" : 13,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 402,
          "y" : 69
        },
        "to" : {
          "x" : 649,
          "y" : 277
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 641,
          "y" : 276
        },
        "b" : {
          "x" : 649,
          "y" : 277
        },
        "c" : {
          "x" : 646,
          "y" : 269
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 646,
          "y" : 269
        }
      }
    } ]
  }, {
    "id" : 8,
    "reactomeId" : 381204,
    "displayName" : "NF-Y",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 506,
      "y" : 59
    },
    "minX" : 203,
    "maxX" : 647,
    "minY" : 43,
    "maxY" : 286,
    "prop" : {
      "x" : 477,
      "y" : 49,
      "width" : 58,
      "height" : 21
    },
    "textPosition" : {
      "x" : 488,
      "y" : 49
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 535,
          "y" : 49
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 535,
          "y" : 49
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 4,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 495,
          "y" : 73
        },
        "to" : {
          "x" : 272,
          "y" : 286
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 274,
          "y" : 278
        },
        "b" : {
          "x" : 272,
          "y" : 286
        },
        "c" : {
          "x" : 280,
          "y" : 284
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 280,
          "y" : 284
        }
      }
    }, {
      "edgeId" : 20,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 530,
          "y" : 73
        },
        "to" : {
          "x" : 647,
          "y" : 121
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 639,
          "y" : 122
        },
        "b" : {
          "x" : 647,
          "y" : 121
        },
        "c" : {
          "x" : 642,
          "y" : 115
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 642,
          "y" : 115
        }
      }
    }, {
      "edgeId" : 9,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 474,
          "y" : 67
        },
        "to" : {
          "x" : 203,
          "y" : 145
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 209,
          "y" : 139
        },
        "b" : {
          "x" : 203,
          "y" : 145
        },
        "c" : {
          "x" : 211,
          "y" : 147
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 211,
          "y" : 147
        }
      }
    } ]
  }, {
    "id" : 10,
    "reactomeId" : 381110,
    "displayName" : "DDIT3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 87,
      "y" : 185
    },
    "minX" : 62,
    "maxX" : 118,
    "minY" : 166,
    "maxY" : 199,
    "prop" : {
      "x" : 62,
      "y" : 172,
      "width" : 50,
      "height" : 27
    },
    "textPosition" : {
      "x" : 65,
      "y" : 175
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 112,
          "y" : 172
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 112,
          "y" : 172
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 9,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 12,
    "reactomeId" : 195905,
    "displayName" : "CALR",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 433,
      "y" : 507
    },
    "minX" : 406,
    "maxX" : 467,
    "minY" : 487,
    "maxY" : 521,
    "prop" : {
      "x" : 406,
      "y" : 493,
      "width" : 55,
      "height" : 28
    },
    "textPosition" : {
      "x" : 414,
      "y" : 496
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 461,
          "y" : 493
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 461,
          "y" : 493
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 11,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 14,
    "reactomeId" : 981545,
    "displayName" : "HSP90B1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 655,
      "y" : 505
    },
    "minX" : 616,
    "maxX" : 700,
    "minY" : 485,
    "maxY" : 519,
    "prop" : {
      "x" : 616,
      "y" : 491,
      "width" : 78,
      "height" : 28
    },
    "textPosition" : {
      "x" : 622,
      "y" : 494
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 694,
          "y" : 491
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 694,
          "y" : 491
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 13,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 21,
    "reactomeId" : 381096,
    "displayName" : "XBP1-2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 723,
      "y" : 166
    },
    "minX" : 695,
    "maxX" : 758,
    "minY" : 147,
    "maxY" : 179,
    "prop" : {
      "x" : 695,
      "y" : 153,
      "width" : 57,
      "height" : 26
    },
    "textPosition" : {
      "x" : 698,
      "y" : 155
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 752,
          "y" : 153
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 752,
          "y" : 153
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 20,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22,
    "reactomeId" : 5642261,
    "displayName" : "HSPA5 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 182,
      "y" : 273
    },
    "minX" : 139,
    "maxX" : 232,
    "minY" : 246,
    "maxY" : 299,
    "prop" : {
      "x" : 139,
      "y" : 248,
      "width" : 86,
      "height" : 51
    },
    "textPosition" : {
      "x" : 139,
      "y" : 275
    },
    "connectors" : [ {
      "edgeId" : 4,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 232,
        "y" : 246
      },
      "b" : {
        "x" : 225,
        "y" : 250
      },
      "c" : {
        "x" : 232,
        "y" : 254
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 232,
        "y" : 254
      }
    }
  }, {
    "id" : 23,
    "reactomeId" : 5642256,
    "displayName" : "DDIT3 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 86,
      "y" : 134
    },
    "minX" : 46,
    "maxX" : 134,
    "minY" : 107,
    "maxY" : 160,
    "prop" : {
      "x" : 46,
      "y" : 109,
      "width" : 81,
      "height" : 51
    },
    "textPosition" : {
      "x" : 46,
      "y" : 136
    },
    "connectors" : [ {
      "edgeId" : 9,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 134,
        "y" : 107
      },
      "b" : {
        "x" : 127,
        "y" : 111
      },
      "c" : {
        "x" : 134,
        "y" : 115
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 134,
        "y" : 115
      }
    }
  }, {
    "id" : 24,
    "reactomeId" : 5642250,
    "displayName" : "CALR gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 354,
      "y" : 284
    },
    "minX" : 317,
    "maxX" : 399,
    "minY" : 257,
    "maxY" : 310,
    "prop" : {
      "x" : 317,
      "y" : 259,
      "width" : 75,
      "height" : 51
    },
    "textPosition" : {
      "x" : 317,
      "y" : 286
    },
    "connectors" : [ {
      "edgeId" : 11,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 399,
        "y" : 257
      },
      "b" : {
        "x" : 392,
        "y" : 261
      },
      "c" : {
        "x" : 399,
        "y" : 265
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 399,
        "y" : 265
      }
    }
  }, {
    "id" : 25,
    "reactomeId" : 5642304,
    "displayName" : "HSP90B1 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 523,
      "y" : 269
    },
    "minX" : 472,
    "maxX" : 581,
    "minY" : 242,
    "maxY" : 295,
    "prop" : {
      "x" : 472,
      "y" : 244,
      "width" : 102,
      "height" : 51
    },
    "textPosition" : {
      "x" : 472,
      "y" : 271
    },
    "connectors" : [ {
      "edgeId" : 13,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 581,
        "y" : 242
      },
      "b" : {
        "x" : 574,
        "y" : 246
      },
      "c" : {
        "x" : 581,
        "y" : 250
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 581,
        "y" : 250
      }
    }
  }, {
    "id" : 26,
    "reactomeId" : 5642223,
    "displayName" : "XBP1 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 563,
      "y" : 146
    },
    "minX" : 525,
    "maxX" : 608,
    "minY" : 119,
    "maxY" : 172,
    "prop" : {
      "x" : 525,
      "y" : 121,
      "width" : 76,
      "height" : 51
    },
    "textPosition" : {
      "x" : 525,
      "y" : 148
    },
    "connectors" : [ {
      "edgeId" : 20,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 608,
        "y" : 119
      },
      "b" : {
        "x" : 601,
        "y" : 123
      },
      "c" : {
        "x" : 608,
        "y" : 127
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 608,
        "y" : 127
      }
    }
  } ],
  "edges" : [ {
    "id" : 4,
    "reactomeId" : 1791150,
    "displayName" : "Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5)",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 265,
      "y" : 292
    },
    "minX" : 234,
    "maxX" : 271,
    "minY" : 250,
    "maxY" : 401,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 234,
        "y" : 250
      },
      "to" : {
        "x" : 265,
        "y" : 292
      }
    }, {
      "from" : {
        "x" : 265,
        "y" : 292
      },
      "to" : {
        "x" : 267,
        "y" : 401
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 263,
        "y" : 394
      },
      "b" : {
        "x" : 267,
        "y" : 401
      },
      "c" : {
        "x" : 271,
        "y" : 394
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 271,
        "y" : 394
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 259,
        "y" : 286
      },
      "b" : {
        "x" : 271,
        "y" : 298
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 265,
        "y" : 292
      }
    },
    "inputs" : [ {
      "id" : 22
    } ],
    "outputs" : [ {
      "id" : 5
    } ],
    "activators" : [ {
      "id" : 6,
      "points" : [ {
        "x" : 256,
        "y" : 212
      } ]
    }, {
      "id" : 7,
      "points" : [ {
        "x" : 380,
        "y" : 69
      } ]
    }, {
      "id" : 8,
      "points" : [ {
        "x" : 495,
        "y" : 73
      } ]
    } ]
  }, {
    "id" : 20,
    "reactomeId" : 1791121,
    "displayName" : "Expression of XBP1(S)",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 655,
      "y" : 124
    },
    "minX" : 610,
    "maxX" : 701,
    "minY" : 118,
    "maxY" : 150,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 610,
        "y" : 123
      },
      "to" : {
        "x" : 655,
        "y" : 124
      }
    }, {
      "from" : {
        "x" : 655,
        "y" : 124
      },
      "to" : {
        "x" : 701,
        "y" : 150
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 693,
        "y" : 150
      },
      "b" : {
        "x" : 701,
        "y" : 150
      },
      "c" : {
        "x" : 697,
        "y" : 143
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 697,
        "y" : 143
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 649,
        "y" : 118
      },
      "b" : {
        "x" : 661,
        "y" : 130
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 655,
        "y" : 124
      }
    },
    "inputs" : [ {
      "id" : 26
    } ],
    "outputs" : [ {
      "id" : 21
    } ],
    "activators" : [ {
      "id" : 7,
      "points" : [ {
        "x" : 438,
        "y" : 65
      } ]
    }, {
      "id" : 8,
      "points" : [ {
        "x" : 530,
        "y" : 73
      } ]
    } ]
  }, {
    "id" : 9,
    "reactomeId" : 1791107,
    "displayName" : "Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 194,
      "y" : 148
    },
    "minX" : 115,
    "maxX" : 200,
    "minY" : 111,
    "maxY" : 176,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 136,
        "y" : 111
      },
      "to" : {
        "x" : 194,
        "y" : 148
      }
    }, {
      "from" : {
        "x" : 194,
        "y" : 148
      },
      "to" : {
        "x" : 115,
        "y" : 176
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 120,
        "y" : 170
      },
      "b" : {
        "x" : 115,
        "y" : 176
      },
      "c" : {
        "x" : 123,
        "y" : 177
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 123,
        "y" : 177
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 188,
        "y" : 142
      },
      "b" : {
        "x" : 200,
        "y" : 154
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 194,
        "y" : 148
      }
    },
    "inputs" : [ {
      "id" : 23
    } ],
    "outputs" : [ {
      "id" : 10
    } ],
    "activators" : [ {
      "id" : 7,
      "points" : [ {
        "x" : 360,
        "y" : 69
      } ]
    }, {
      "id" : 8,
      "points" : [ {
        "x" : 474,
        "y" : 67
      } ]
    }, {
      "id" : 6,
      "points" : [ {
        "x" : 240,
        "y" : 182
      } ]
    } ]
  }, {
    "id" : 11,
    "reactomeId" : 1791082,
    "displayName" : "Expression of Calreticulin",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 431,
      "y" : 311
    },
    "minX" : 401,
    "maxX" : 437,
    "minY" : 261,
    "maxY" : 490,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 401,
        "y" : 261
      },
      "to" : {
        "x" : 431,
        "y" : 311
      }
    }, {
      "from" : {
        "x" : 431,
        "y" : 311
      },
      "to" : {
        "x" : 432,
        "y" : 490
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 428,
        "y" : 483
      },
      "b" : {
        "x" : 432,
        "y" : 490
      },
      "c" : {
        "x" : 436,
        "y" : 483
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 436,
        "y" : 483
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 425,
        "y" : 305
      },
      "b" : {
        "x" : 437,
        "y" : 317
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 431,
        "y" : 311
      }
    },
    "inputs" : [ {
      "id" : 24
    } ],
    "outputs" : [ {
      "id" : 12
    } ],
    "activators" : [ {
      "id" : 7,
      "points" : [ {
        "x" : 389,
        "y" : 69
      } ]
    } ]
  }, {
    "id" : 13,
    "reactomeId" : 1791163,
    "displayName" : "Expression of HSP90B1 (Endoplasmin)",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 656,
      "y" : 283
    },
    "minX" : 583,
    "maxX" : 662,
    "minY" : 246,
    "maxY" : 488,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 583,
        "y" : 246
      },
      "to" : {
        "x" : 656,
        "y" : 283
      }
    }, {
      "from" : {
        "x" : 656,
        "y" : 283
      },
      "to" : {
        "x" : 655,
        "y" : 488
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 651,
        "y" : 481
      },
      "b" : {
        "x" : 655,
        "y" : 488
      },
      "c" : {
        "x" : 659,
        "y" : 481
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 659,
        "y" : 481
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 650,
        "y" : 277
      },
      "b" : {
        "x" : 662,
        "y" : 289
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 656,
        "y" : 283
      }
    },
    "inputs" : [ {
      "id" : 25
    } ],
    "outputs" : [ {
      "id" : 14
    } ],
    "activators" : [ {
      "id" : 7,
      "points" : [ {
        "x" : 402,
        "y" : 69
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 1,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 403,
      "y" : 326
    },
    "minX" : 0,
    "maxX" : 806,
    "minY" : 0,
    "maxY" : 652,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 806,
      "height" : 652
    },
    "textPosition" : {
      "x" : 20,
      "y" : 596
    },
    "insets" : {
      "x" : 11,
      "y" : 10,
      "width" : 781,
      "height" : 624
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 2, 3 ]
  }, {
    "id" : 2,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 402,
      "y" : 483
    },
    "minX" : 66,
    "maxX" : 738,
    "minY" : 372,
    "maxY" : 594,
    "prop" : {
      "x" : 66,
      "y" : 372,
      "width" : 672,
      "height" : 222
    },
    "textPosition" : {
      "x" : 86,
      "y" : 542
    },
    "insets" : {
      "x" : 76,
      "y" : 450,
      "width" : 650,
      "height" : 128
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 5, 12, 14 ]
  }, {
    "id" : 3,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 401,
      "y" : 180
    },
    "minX" : 26,
    "maxX" : 777,
    "minY" : 23,
    "maxY" : 338,
    "prop" : {
      "x" : 26,
      "y" : 23,
      "width" : 751,
      "height" : 315
    },
    "textPosition" : {
      "x" : 36,
      "y" : 294
    },
    "insets" : {
      "x" : 33,
      "y" : 30,
      "width" : 737,
      "height" : 303
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 6, 7, 8, 20, 21, 10, 9, 4, 22, 23, 24, 25, 26, 11, 13 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 806,
  "minY" : 0,
  "maxY" : 652,
  "disease" : false
}