{
  "dbId" : 3656532,
  "stId" : "R-HSA-3656532",
  "speciesName" : "Homo sapiens",
  "nodes" : [ {
    "dbId" : 2173793,
    "stId" : "R-HSA-2173793",
    "displayName" : "Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer",
    "schemaClass" : "Pathway",
    "speciesId" : 48887,
    "diagramIds" : [ 27 ]
  }, {
    "dbId" : 170855,
    "stId" : "R-HSA-170855",
    "displayName" : "SMAD3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 466 ],
    "identifier" : "P84022",
    "standardIdentifier" : "uniprot:P84022",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SMAD3", "MADH3" ],
    "parents" : [ 171172 ],
    "children" : [ ]
  }, {
    "dbId" : 170852,
    "stId" : "R-HSA-170852",
    "displayName" : "Dimeric TGFB1 [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 6 ],
    "parents" : [ 3656513 ],
    "children" : [ 170838 ]
  }, {
    "dbId" : 171172,
    "stId" : "R-HSA-171172",
    "displayName" : "SMAD2,3 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 48887,
    "diagramIds" : [ 12 ],
    "parents" : [ ],
    "children" : [ 3006353, 170855 ]
  }, {
    "dbId" : 206180,
    "stId" : "R-HSA-206180",
    "displayName" : "ZFYVE9-1 [early endosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 517 ],
    "identifier" : "O95405-1",
    "standardIdentifier" : "uniprot:O95405-1",
    "referenceType" : "ReferenceIsoform",
    "geneNames" : [ "ZFYVE9", "MADHIP", "SARA", "SMADIP" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 3656509,
    "stId" : "R-HSA-3656509",
    "displayName" : "p-4S,T185,T186-TGFBR1 D269_Q324del [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P36897",
    "standardIdentifier" : "uniprot:P36897",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TGFBR1", "ALK5", "SKR4" ],
    "parents" : [ 3656516 ],
    "children" : [ ]
  }, {
    "dbId" : 3656508,
    "stId" : "R-HSA-3656508",
    "displayName" : "p-4S,T185,T186-TGFBR1 R414* [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P36897",
    "standardIdentifier" : "uniprot:P36897",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TGFBR1", "ALK5", "SKR4" ],
    "parents" : [ 3656516 ],
    "children" : [ ]
  }, {
    "dbId" : 3656506,
    "stId" : "R-HSA-3656506",
    "displayName" : "p-4S,T185,T186-TGFBR1 L354Nfs*4 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P36897",
    "standardIdentifier" : "uniprot:P36897",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TGFBR1", "ALK5", "SKR4" ],
    "parents" : [ 3656516 ],
    "children" : [ ]
  }, {
    "dbId" : 3656505,
    "stId" : "R-HSA-3656505",
    "displayName" : "p-4S,T185,T186-TGFBR1 P327Qfs*8 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P36897",
    "standardIdentifier" : "uniprot:P36897",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TGFBR1", "ALK5", "SKR4" ],
    "parents" : [ 3656516 ],
    "children" : [ ]
  }, {
    "dbId" : 3656504,
    "stId" : "R-HSA-3656504",
    "displayName" : "p-4S,T185,T186-TGFBR1 W242* [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P36897",
    "standardIdentifier" : "uniprot:P36897",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TGFBR1", "ALK5", "SKR4" ],
    "parents" : [ 3656516 ],
    "children" : [ ]
  }, {
    "dbId" : 170866,
    "stId" : "R-HSA-170866",
    "displayName" : "TGFBR2 homodimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 3656513 ],
    "children" : [ 170842 ]
  }, {
    "dbId" : 3656516,
    "stId" : "R-HSA-3656516",
    "displayName" : "p-4S-T185,T186-TGFBR1 KD Mutants [plasma membrane]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 48887,
    "parents" : [ 3656514 ],
    "children" : [ 3656504, 3656505, 3656506, 3656508, 3656509 ]
  }, {
    "dbId" : 170838,
    "stId" : "R-HSA-170838",
    "displayName" : "TGFB1 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "identifier" : "P01137",
    "standardIdentifier" : "uniprot:P01137",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TGFB1", "TGFB" ],
    "parents" : [ 170852 ],
    "children" : [ ]
  }, {
    "dbId" : 3656514,
    "stId" : "R-HSA-3656514",
    "displayName" : "p-TGFBR1 KD Mutants Homodimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "parents" : [ 3656513 ],
    "children" : [ 3656516 ]
  }, {
    "dbId" : 3656513,
    "stId" : "R-HSA-3656513",
    "displayName" : "TGFB1:TGFBR2:p-TGFBR1 KD Mutants [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48887,
    "diagramIds" : [ 105503 ],
    "parents" : [ ],
    "children" : [ 170852, 3656514, 170866 ]
  }, {
    "dbId" : 170842,
    "stId" : "R-HSA-170842",
    "displayName" : "TGFBR2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 527 ],
    "identifier" : "P37173",
    "standardIdentifier" : "uniprot:P37173",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "TGFBR2" ],
    "parents" : [ 170866 ],
    "children" : [ ]
  }, {
    "dbId" : 3006353,
    "stId" : "R-HSA-3006353",
    "displayName" : "SMAD2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48887,
    "diagramIds" : [ 525 ],
    "identifier" : "Q15796",
    "standardIdentifier" : "uniprot:Q15796",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "SMAD2", "MADH2", "MADR2" ],
    "parents" : [ 171172 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 3656523,
    "stId" : "R-HSA-3656523",
    "displayName" : "An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants",
    "schemaClass" : "FailedReaction",
    "speciesId" : 0,
    "inputs" : [ 206180, 3656513, 171172 ],
    "efs" : [ 3656513 ],
    "diagramIds" : [ 105502 ],
    "entityFunctionalStatus" : [ 3656513 ]
  } ]
}