{
  "dbId" : 2173793,
  "stableId" : "R-HSA-2173793",
  "displayName" : "Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer",
  "nodes" : [ {
    "id" : 1283,
    "reactomeId" : 171172,
    "displayName" : "SMAD2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1355,
      "y" : 358
    },
    "minX" : 1285,
    "maxX" : 1389,
    "minY" : 347,
    "maxY" : 369,
    "prop" : {
      "x" : 1322,
      "y" : 347,
      "width" : 67,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1324,
      "y" : 347
    },
    "connectors" : [ {
      "edgeId" : 1282,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1309,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1316,
          "y" : 357
        },
        "to" : {
          "x" : 1285,
          "y" : 356
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1027,
    "reactomeId" : 2186733,
    "displayName" : "Ub-SKI/Ub-SKIL",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1376,
      "y" : 1065
    },
    "minX" : 1286,
    "maxX" : 1434,
    "minY" : 1048,
    "maxY" : 1076,
    "prop" : {
      "x" : 1325,
      "y" : 1054,
      "width" : 103,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1328,
      "y" : 1055
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1428,
          "y" : 1054
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1428,
          "y" : 1054
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1026,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1322,
          "y" : 1070
        },
        "to" : {
          "x" : 1286,
          "y" : 1075
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1316,
          "y" : 1075
        },
        "b" : {
          "x" : 1322,
          "y" : 1070
        },
        "c" : {
          "x" : 1315,
          "y" : 1067
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1315,
          "y" : 1067
        }
      }
    }, {
      "edgeId" : 1114,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1029,
    "reactomeId" : 68524,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1221,
      "y" : 1120
    },
    "minX" : 1189,
    "maxX" : 1253,
    "minY" : 1088,
    "maxY" : 1131,
    "prop" : {
      "x" : 1189,
      "y" : 1110,
      "width" : 64,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1208,
      "y" : 1110
    },
    "connectors" : [ {
      "edgeId" : 1026,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1223,
          "y" : 1104
        },
        "to" : {
          "x" : 1230,
          "y" : 1088
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1546,
    "reactomeId" : 2187328,
    "displayName" : "PAR-SMAD2,3:PAR-SMAD4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1314,
      "y" : 565
    },
    "minX" : 1175,
    "maxX" : 1364,
    "minY" : 547,
    "maxY" : 583,
    "prop" : {
      "x" : 1265,
      "y" : 547,
      "width" : 99,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1267,
      "y" : 547
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 1239,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1259,
          "y" : 558
        },
        "to" : {
          "x" : 1175,
          "y" : 548
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1252,
          "y" : 561
        },
        "b" : {
          "x" : 1259,
          "y" : 558
        },
        "c" : {
          "x" : 1253,
          "y" : 553
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1253,
          "y" : 553
        }
      }
    } ]
  }, {
    "id" : 1297,
    "reactomeId" : 170834,
    "displayName" : "Signaling by TGF-beta Receptor Complex",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 801,
      "y" : 103
    },
    "minX" : 715,
    "maxX" : 887,
    "minY" : 77,
    "maxY" : 129,
    "prop" : {
      "x" : 715,
      "y" : 77,
      "width" : 172,
      "height" : 52
    },
    "textPosition" : {
      "x" : 723,
      "y" : 81
    },
    "connectors" : [ ]
  }, {
    "id" : 1303,
    "reactomeId" : 351663,
    "displayName" : "SNW1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2005,
      "y" : 666
    },
    "minX" : 1983,
    "maxX" : 2038,
    "minY" : 649,
    "maxY" : 706,
    "prop" : {
      "x" : 1983,
      "y" : 655,
      "width" : 44,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1983,
      "y" : 655
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2027,
          "y" : 655
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2027,
          "y" : 655
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1302,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2014,
          "y" : 680
        },
        "to" : {
          "x" : 2038,
          "y" : 706
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1304,
    "reactomeId" : 939761,
    "displayName" : "ATP1B4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2081,
      "y" : 666
    },
    "minX" : 2038,
    "maxX" : 2115,
    "minY" : 649,
    "maxY" : 706,
    "prop" : {
      "x" : 2053,
      "y" : 655,
      "width" : 56,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2053,
      "y" : 655
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2109,
          "y" : 655
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2109,
          "y" : 655
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1302,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2069,
          "y" : 680
        },
        "to" : {
          "x" : 2038,
          "y" : 706
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1305,
    "reactomeId" : 5252105,
    "displayName" : "ATP1B4:SNW1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2003,
      "y" : 761
    },
    "minX" : 1756,
    "maxX" : 2057,
    "minY" : 744,
    "maxY" : 822,
    "prop" : {
      "x" : 1956,
      "y" : 750,
      "width" : 95,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1956,
      "y" : 751
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2051,
          "y" : 750
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2051,
          "y" : 750
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1302,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1829,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1956,
          "y" : 775
        },
        "to" : {
          "x" : 1756,
          "y" : 820
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1762,
          "y" : 815
        },
        "b" : {
          "x" : 1756,
          "y" : 820
        },
        "c" : {
          "x" : 1764,
          "y" : 822
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1764,
          "y" : 822
        }
      }
    } ]
  }, {
    "id" : 1307,
    "reactomeId" : 8981023,
    "displayName" : "FURIN gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 525,
      "y" : 599
    },
    "minX" : 488,
    "maxX" : 569,
    "minY" : 572,
    "maxY" : 625,
    "prop" : {
      "x" : 488,
      "y" : 574,
      "width" : 74,
      "height" : 51
    },
    "textPosition" : {
      "x" : 501,
      "y" : 601
    },
    "connectors" : [ {
      "edgeId" : 2038,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 569,
        "y" : 572
      },
      "b" : {
        "x" : 562,
        "y" : 576
      },
      "c" : {
        "x" : 569,
        "y" : 580
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 569,
        "y" : 580
      }
    }
  }, {
    "id" : 2078,
    "reactomeId" : 9773846,
    "displayName" : "Ub,p-T,S-SMAD2/3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1368,
      "y" : 864
    },
    "minX" : 1293,
    "maxX" : 1443,
    "minY" : 802,
    "maxY" : 875,
    "prop" : {
      "x" : 1293,
      "y" : 853,
      "width" : 150,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1308,
      "y" : 853
    },
    "connectors" : [ {
      "edgeId" : 838,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1364,
          "y" : 847
        },
        "to" : {
          "x" : 1350,
          "y" : 802
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1351,
            "y" : 818
          },
          "b" : {
            "x" : 1363,
            "y" : 830
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1357,
            "y" : 824
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1358,
          "y" : 842
        },
        "b" : {
          "x" : 1364,
          "y" : 847
        },
        "c" : {
          "x" : 1366,
          "y" : 839
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1366,
          "y" : 839
        }
      }
    } ]
  }, {
    "id" : 1310,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1291,
      "y" : 282
    },
    "minX" : 1273,
    "maxX" : 1311,
    "minY" : 270,
    "maxY" : 356,
    "prop" : {
      "x" : 1273,
      "y" : 271,
      "width" : 37,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1276,
      "y" : 272
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1305,
          "y" : 276
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1305,
          "y" : 276
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1309,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1290,
          "y" : 297
        },
        "to" : {
          "x" : 1285,
          "y" : 356
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1281,
            "y" : 320
          },
          "b" : {
            "x" : 1293,
            "y" : 332
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1287,
            "y" : 326
          }
        }
      }
    } ]
  }, {
    "id" : 1823,
    "reactomeId" : 9736973,
    "displayName" : "WWTR1:p-2S-SMAD2,3:SMAD4:SMAD7 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1766,
      "y" : 654
    },
    "minX" : 1711,
    "maxX" : 1828,
    "minY" : 623,
    "maxY" : 813,
    "prop" : {
      "x" : 1711,
      "y" : 629,
      "width" : 111,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1715,
      "y" : 616
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1822,
          "y" : 629
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1822,
          "y" : 629
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1822,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1829,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1763,
          "y" : 682
        },
        "to" : {
          "x" : 1748,
          "y" : 813
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1745,
          "y" : 806
        },
        "b" : {
          "x" : 1748,
          "y" : 813
        },
        "c" : {
          "x" : 1753,
          "y" : 807
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1753,
          "y" : 807
        }
      }
    } ]
  }, {
    "id" : 1311,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1221,
      "y" : 288
    },
    "minX" : 1203,
    "maxX" : 1241,
    "minY" : 277,
    "maxY" : 362,
    "prop" : {
      "x" : 1203,
      "y" : 278,
      "width" : 37,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1205,
      "y" : 278
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1235,
          "y" : 283
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1235,
          "y" : 283
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1309,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1221,
          "y" : 302
        },
        "to" : {
          "x" : 1222,
          "y" : 362
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1215,
            "y" : 326
          },
          "b" : {
            "x" : 1227,
            "y" : 338
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1221,
            "y" : 332
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1225,
          "y" : 309
        },
        "b" : {
          "x" : 1221,
          "y" : 302
        },
        "c" : {
          "x" : 1217,
          "y" : 309
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1217,
          "y" : 309
        }
      }
    } ]
  }, {
    "id" : 1312,
    "reactomeId" : 9731119,
    "displayName" : "p-S250-SMAD2,p-S208-SMAD3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1097,
      "y" : 306
    },
    "minX" : 1042,
    "maxX" : 1222,
    "minY" : 289,
    "maxY" : 362,
    "prop" : {
      "x" : 1042,
      "y" : 289,
      "width" : 110,
      "height" : 34
    },
    "textPosition" : {
      "x" : 1045,
      "y" : 289
    },
    "connectors" : [ {
      "edgeId" : 1309,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1134,
          "y" : 329
        },
        "to" : {
          "x" : 1222,
          "y" : 362
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1142,
          "y" : 328
        },
        "b" : {
          "x" : 1134,
          "y" : 329
        },
        "c" : {
          "x" : 1139,
          "y" : 335
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1139,
          "y" : 335
        }
      }
    } ]
  }, {
    "id" : 1313,
    "reactomeId" : 1268261,
    "displayName" : "p-T,Y MAPK dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1097,
      "y" : 378
    },
    "minX" : 865,
    "maxX" : 1256,
    "minY" : 365,
    "maxY" : 431,
    "prop" : {
      "x" : 1027,
      "y" : 365,
      "width" : 140,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1036,
      "y" : 367
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 1436,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1035,
          "y" : 397
        },
        "to" : {
          "x" : 866,
          "y" : 427
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 865,
          "y" : 423
        },
        "b" : {
          "x" : 867,
          "y" : 431
        },
        "c" : {
          "x" : 866,
          "y" : 427
        },
        "type" : "STOP",
        "centre" : {
          "x" : 866,
          "y" : 427
        }
      }
    }, {
      "edgeId" : 1309,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1173,
          "y" : 390
        },
        "to" : {
          "x" : 1238,
          "y" : 404
        }
      }, {
        "from" : {
          "x" : 1238,
          "y" : 404
        },
        "to" : {
          "x" : 1251,
          "y" : 376
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1252,
          "y" : 372
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1252,
          "y" : 372
        }
      }
    } ]
  }, {
    "id" : 1321,
    "reactomeId" : 873824,
    "displayName" : "p-STAT1 homodimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1642,
      "y" : 709
    },
    "minX" : 1593,
    "maxX" : 1721,
    "minY" : 685,
    "maxY" : 833,
    "prop" : {
      "x" : 1593,
      "y" : 691,
      "width" : 99,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1603,
      "y" : 692
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1692,
          "y" : 691
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1692,
          "y" : 691
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1320,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1653,
          "y" : 730
        },
        "to" : {
          "x" : 1721,
          "y" : 833
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1714,
          "y" : 829
        },
        "b" : {
          "x" : 1721,
          "y" : 833
        },
        "c" : {
          "x" : 1721,
          "y" : 825
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1721,
          "y" : 825
        }
      }
    } ]
  }, {
    "id" : 1579,
    "reactomeId" : 2176487,
    "displayName" : "p-T,2S-SMAD2,3:SMAD4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1077,
      "y" : 653
    },
    "minX" : 992,
    "maxX" : 1154,
    "minY" : 636,
    "maxY" : 696,
    "prop" : {
      "x" : 1020,
      "y" : 636,
      "width" : 115,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1022,
      "y" : 636
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 681,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1014,
          "y" : 655
        },
        "to" : {
          "x" : 992,
          "y" : 656
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1007,
          "y" : 659
        },
        "b" : {
          "x" : 1014,
          "y" : 655
        },
        "c" : {
          "x" : 1007,
          "y" : 651
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1007,
          "y" : 651
        }
      }
    }, {
      "edgeId" : 711,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1141,
          "y" : 648
        },
        "to" : {
          "x" : 1154,
          "y" : 647
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 759,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1103,
          "y" : 677
        },
        "to" : {
          "x" : 1141,
          "y" : 696
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 556,
    "reactomeId" : 1629773,
    "displayName" : "WWTR1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 933,
      "y" : 190
    },
    "minX" : 907,
    "maxX" : 966,
    "minY" : 173,
    "maxY" : 250,
    "prop" : {
      "x" : 907,
      "y" : 179,
      "width" : 53,
      "height" : 22
    },
    "textPosition" : {
      "x" : 907,
      "y" : 179
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 960,
          "y" : 179
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 960,
          "y" : 179
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1437,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 939,
          "y" : 204
        },
        "to" : {
          "x" : 966,
          "y" : 250
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 557,
    "reactomeId" : 2031357,
    "displayName" : "WWTR1:p-2S-SMAD2,3:SMAD4",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1508,
      "y" : 383
    },
    "minX" : 1409,
    "maxX" : 1614,
    "minY" : 366,
    "maxY" : 394,
    "prop" : {
      "x" : 1409,
      "y" : 372,
      "width" : 199,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1413,
      "y" : 373
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1608,
          "y" : 372
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1608,
          "y" : 372
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1687,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1437,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1332,
    "reactomeId" : 157049,
    "displayName" : "FURIN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 316,
      "y" : 612
    },
    "minX" : 295,
    "maxX" : 344,
    "minY" : 595,
    "maxY" : 623,
    "prop" : {
      "x" : 295,
      "y" : 601,
      "width" : 43,
      "height" : 22
    },
    "textPosition" : {
      "x" : 299,
      "y" : 595
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 338,
          "y" : 601
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 338,
          "y" : 601
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1639,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2038,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 570,
    "reactomeId" : 2106580,
    "displayName" : "WWTR1:p-2S-SMAD2,3:SMAD4",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1509,
      "y" : 810
    },
    "minX" : 1410,
    "maxX" : 1668,
    "minY" : 773,
    "maxY" : 875,
    "prop" : {
      "x" : 1410,
      "y" : 799,
      "width" : 199,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1414,
      "y" : 800
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1609,
          "y" : 799
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1609,
          "y" : 799
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1687,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1822,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1556,
          "y" : 796
        },
        "to" : {
          "x" : 1668,
          "y" : 773
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1709,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1509,
          "y" : 824
        },
        "to" : {
          "x" : 1513,
          "y" : 875
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 583,
    "reactomeId" : 2106587,
    "displayName" : "SMAD7 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 1585,
      "y" : 856
    },
    "minX" : 1540,
    "maxX" : 1668,
    "minY" : 773,
    "maxY" : 882,
    "prop" : {
      "x" : 1540,
      "y" : 831,
      "width" : 90,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1541,
      "y" : 858
    },
    "connectors" : [ {
      "edgeId" : 1822,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1639,
          "y" : 833
        },
        "to" : {
          "x" : 1668,
          "y" : 773
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1829,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1320,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1637,
        "y" : 829
      },
      "b" : {
        "x" : 1630,
        "y" : 833
      },
      "c" : {
        "x" : 1637,
        "y" : 837
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1637,
        "y" : 837
      }
    }
  }, {
    "id" : 584,
    "reactomeId" : 178197,
    "displayName" : "SMAD7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1841,
      "y" : 826
    },
    "minX" : 1681,
    "maxX" : 1878,
    "minY" : 811,
    "maxY" : 1013,
    "prop" : {
      "x" : 1811,
      "y" : 817,
      "width" : 61,
      "height" : 18
    },
    "textPosition" : {
      "x" : 1816,
      "y" : 816
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1872,
          "y" : 817
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1872,
          "y" : 817
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1829,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1320,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1755,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1833,
          "y" : 838
        },
        "to" : {
          "x" : 1681,
          "y" : 1013
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1132,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1840,
          "y" : 838
        },
        "to" : {
          "x" : 1840,
          "y" : 894
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 840,
    "reactomeId" : 177103,
    "displayName" : "SMAD4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1483,
      "y" : 747
    },
    "minX" : 1250,
    "maxX" : 1514,
    "minY" : 505,
    "maxY" : 802,
    "prop" : {
      "x" : 1458,
      "y" : 736,
      "width" : 50,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1461,
      "y" : 730
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1508,
          "y" : 736
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1508,
          "y" : 736
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 838,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1455,
          "y" : 757
        },
        "to" : {
          "x" : 1350,
          "y" : 802
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1396,
            "y" : 773
          },
          "b" : {
            "x" : 1408,
            "y" : 785
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1402,
            "y" : 779
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1450,
          "y" : 763
        },
        "b" : {
          "x" : 1455,
          "y" : 757
        },
        "c" : {
          "x" : 1447,
          "y" : 756
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1447,
          "y" : 756
        }
      }
    }, {
      "edgeId" : 1276,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1483,
          "y" : 733
        },
        "to" : {
          "x" : 1489,
          "y" : 568
        }
      }, {
        "from" : {
          "x" : 1489,
          "y" : 568
        },
        "to" : {
          "x" : 1250,
          "y" : 505
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1480,
            "y" : 644
          },
          "b" : {
            "x" : 1492,
            "y" : 656
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1486,
            "y" : 650
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1479,
          "y" : 726
        },
        "b" : {
          "x" : 1483,
          "y" : 733
        },
        "c" : {
          "x" : 1487,
          "y" : 726
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1487,
          "y" : 726
        }
      }
    } ]
  }, {
    "id" : 590,
    "reactomeId" : 2106592,
    "displayName" : "SERPINE1 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 1462,
      "y" : 945
    },
    "minX" : 1409,
    "maxX" : 1681,
    "minY" : 875,
    "maxY" : 1013,
    "prop" : {
      "x" : 1409,
      "y" : 920,
      "width" : 106,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1410,
      "y" : 947
    },
    "connectors" : [ {
      "edgeId" : 1709,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1524,
          "y" : 922
        },
        "to" : {
          "x" : 1513,
          "y" : 875
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1716,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1755,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1524,
          "y" : 922
        },
        "to" : {
          "x" : 1681,
          "y" : 1013
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1522,
        "y" : 918
      },
      "b" : {
        "x" : 1515,
        "y" : 922
      },
      "c" : {
        "x" : 1522,
        "y" : 926
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1522,
        "y" : 926
      }
    }
  }, {
    "id" : 1362,
    "reactomeId" : 6789344,
    "displayName" : "COL1A2 gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 518,
      "y" : 1178
    },
    "minX" : 484,
    "maxX" : 745,
    "minY" : 1151,
    "maxY" : 1347,
    "prop" : {
      "x" : 484,
      "y" : 1153,
      "width" : 68,
      "height" : 51
    },
    "textPosition" : {
      "x" : 488,
      "y" : 1180
    },
    "connectors" : [ {
      "edgeId" : 1361,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 561,
          "y" : 1155
        },
        "to" : {
          "x" : 745,
          "y" : 1163
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1394,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1404,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 561,
          "y" : 1155
        },
        "to" : {
          "x" : 679,
          "y" : 1347
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 559,
        "y" : 1151
      },
      "b" : {
        "x" : 552,
        "y" : 1155
      },
      "c" : {
        "x" : 559,
        "y" : 1159
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 559,
        "y" : 1159
      }
    }
  }, {
    "id" : 1363,
    "reactomeId" : 8878153,
    "displayName" : "p-2S-SMAD3:p-2S-SMAD3:SMAD4",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 763,
      "y" : 1065
    },
    "minX" : 679,
    "maxX" : 819,
    "minY" : 1036,
    "maxY" : 1347,
    "prop" : {
      "x" : 715,
      "y" : 1042,
      "width" : 97,
      "height" : 47
    },
    "textPosition" : {
      "x" : 720,
      "y" : 1040
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 812,
          "y" : 1042
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 812,
          "y" : 1042
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1361,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 758,
          "y" : 1092
        },
        "to" : {
          "x" : 745,
          "y" : 1163
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1404,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 768,
          "y" : 1092
        },
        "to" : {
          "x" : 819,
          "y" : 1309
        }
      }, {
        "from" : {
          "x" : 819,
          "y" : 1309
        },
        "to" : {
          "x" : 679,
          "y" : 1347
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1364,
    "reactomeId" : 381325,
    "displayName" : "EP300",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 548,
      "y" : 1104
    },
    "minX" : 525,
    "maxX" : 745,
    "minY" : 1087,
    "maxY" : 1163,
    "prop" : {
      "x" : 525,
      "y" : 1093,
      "width" : 47,
      "height" : 22
    },
    "textPosition" : {
      "x" : 528,
      "y" : 1087
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 572,
          "y" : 1093
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 572,
          "y" : 1093
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1361,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 575,
          "y" : 1111
        },
        "to" : {
          "x" : 745,
          "y" : 1163
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1365,
    "reactomeId" : 9733206,
    "displayName" : "p-2S-SMAD3:p-2S-SMAD3:SMAD4:SP1:EP300:COL1A2 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 729,
      "y" : 1247
    },
    "minX" : 565,
    "maxX" : 800,
    "minY" : 1214,
    "maxY" : 1305,
    "prop" : {
      "x" : 665,
      "y" : 1220,
      "width" : 129,
      "height" : 54
    },
    "textPosition" : {
      "x" : 664,
      "y" : 1211
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 794,
          "y" : 1220
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 794,
          "y" : 1220
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1361,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1394,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 662,
          "y" : 1269
        },
        "to" : {
          "x" : 565,
          "y" : 1304
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 570,
          "y" : 1298
        },
        "b" : {
          "x" : 565,
          "y" : 1304
        },
        "c" : {
          "x" : 573,
          "y" : 1305
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 573,
          "y" : 1305
        }
      }
    } ]
  }, {
    "id" : 598,
    "reactomeId" : 2127252,
    "displayName" : "RBL1:E2F4/5:DP1/2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 954,
      "y" : 1269
    },
    "minX" : 922,
    "maxX" : 992,
    "minY" : 1196,
    "maxY" : 1293,
    "prop" : {
      "x" : 922,
      "y" : 1245,
      "width" : 64,
      "height" : 48
    },
    "textPosition" : {
      "x" : 926,
      "y" : 1244
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 986,
          "y" : 1245
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 986,
          "y" : 1245
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 597,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 952,
          "y" : 1242
        },
        "to" : {
          "x" : 949,
          "y" : 1196
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 599,
    "reactomeId" : 2127250,
    "displayName" : "p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1171,
      "y" : 1199
    },
    "minX" : 1098,
    "maxX" : 1280,
    "minY" : 1175,
    "maxY" : 1228,
    "prop" : {
      "x" : 1098,
      "y" : 1181,
      "width" : 147,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1098,
      "y" : 1182
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1245,
          "y" : 1181
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1245,
          "y" : 1181
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1972,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1238,
          "y" : 1220
        },
        "to" : {
          "x" : 1280,
          "y" : 1228
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 597,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 862,
    "reactomeId" : 205021,
    "displayName" : "HDAC1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1131,
      "y" : 815
    },
    "minX" : 1001,
    "maxX" : 1163,
    "minY" : 775,
    "maxY" : 826,
    "prop" : {
      "x" : 1106,
      "y" : 804,
      "width" : 51,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1106,
      "y" : 804
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1157,
          "y" : 804
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1157,
          "y" : 804
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 861,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1103,
          "y" : 807
        },
        "to" : {
          "x" : 1001,
          "y" : 775
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 864,
    "reactomeId" : 2186606,
    "displayName" : "p-2S-SMAD2/3:SMAD4:TGIF:HDAC1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1181,
      "y" : 883
    },
    "minX" : 1115,
    "maxX" : 1554,
    "minY" : 859,
    "maxY" : 1072,
    "prop" : {
      "x" : 1115,
      "y" : 865,
      "width" : 133,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1118,
      "y" : 866
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1248,
          "y" : 865
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1248,
          "y" : 865
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1716,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1217,
          "y" : 904
        },
        "to" : {
          "x" : 1552,
          "y" : 1068
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1550,
          "y" : 1072
        },
        "b" : {
          "x" : 1554,
          "y" : 1064
        },
        "c" : {
          "x" : 1552,
          "y" : 1068
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1552,
          "y" : 1068
        }
      }
    }, {
      "edgeId" : 861,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 871,
    "reactomeId" : 177105,
    "displayName" : "p-2S-SMAD2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 728,
      "y" : 489
    },
    "minX" : 672,
    "maxX" : 785,
    "minY" : 477,
    "maxY" : 548,
    "prop" : {
      "x" : 672,
      "y" : 477,
      "width" : 113,
      "height" : 25
    },
    "textPosition" : {
      "x" : 681,
      "y" : 479
    },
    "connectors" : [ {
      "edgeId" : 869,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 721,
          "y" : 508
        },
        "to" : {
          "x" : 698,
          "y" : 548
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 703,
            "y" : 522
          },
          "b" : {
            "x" : 715,
            "y" : 534
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 709,
            "y" : 528
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 721,
          "y" : 516
        },
        "b" : {
          "x" : 721,
          "y" : 508
        },
        "c" : {
          "x" : 714,
          "y" : 512
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 714,
          "y" : 512
        }
      }
    } ]
  }, {
    "id" : 1640,
    "reactomeId" : 2159856,
    "displayName" : "FURIN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 222,
      "y" : 48
    },
    "minX" : 201,
    "maxX" : 250,
    "minY" : 31,
    "maxY" : 59,
    "prop" : {
      "x" : 201,
      "y" : 37,
      "width" : 43,
      "height" : 22
    },
    "textPosition" : {
      "x" : 205,
      "y" : 31
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 244,
          "y" : 37
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 244,
          "y" : 37
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1639,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 873,
    "reactomeId" : 68524,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 630,
      "y" : 602
    },
    "minX" : 607,
    "maxX" : 709,
    "minY" : 592,
    "maxY" : 613,
    "prop" : {
      "x" : 607,
      "y" : 592,
      "width" : 46,
      "height" : 21
    },
    "textPosition" : {
      "x" : 617,
      "y" : 592
    },
    "connectors" : [ {
      "edgeId" : 869,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 659,
          "y" : 601
        },
        "to" : {
          "x" : 709,
          "y" : 601
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 678,
            "y" : 595
          },
          "b" : {
            "x" : 690,
            "y" : 607
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 684,
            "y" : 601
          }
        }
      }
    } ]
  }, {
    "id" : 1133,
    "reactomeId" : 2186765,
    "displayName" : "RNF111",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1814,
      "y" : 986
    },
    "minX" : 1784,
    "maxX" : 1972,
    "minY" : 894,
    "maxY" : 999,
    "prop" : {
      "x" : 1784,
      "y" : 974,
      "width" : 61,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1786,
      "y" : 976
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1845,
          "y" : 974
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1845,
          "y" : 974
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1132,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1817,
          "y" : 971
        },
        "to" : {
          "x" : 1840,
          "y" : 894
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1143,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1848,
          "y" : 984
        },
        "to" : {
          "x" : 1972,
          "y" : 977
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1855,
          "y" : 980
        },
        "b" : {
          "x" : 1848,
          "y" : 984
        },
        "c" : {
          "x" : 1855,
          "y" : 988
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1855,
          "y" : 988
        }
      }
    } ]
  }, {
    "id" : 1134,
    "reactomeId" : 2186769,
    "displayName" : "SMAD7:RNF111",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1972,
      "y" : 902
    },
    "minX" : 1943,
    "maxX" : 2007,
    "minY" : 879,
    "maxY" : 955,
    "prop" : {
      "x" : 1943,
      "y" : 885,
      "width" : 58,
      "height" : 34
    },
    "textPosition" : {
      "x" : 1944,
      "y" : 884
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2001,
          "y" : 885
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2001,
          "y" : 885
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1132,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1143,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1972,
          "y" : 922
        },
        "to" : {
          "x" : 1972,
          "y" : 941
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1143,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1961,
          "y" : 922
        },
        "to" : {
          "x" : 1950,
          "y" : 937
        }
      }, {
        "from" : {
          "x" : 1950,
          "y" : 937
        },
        "to" : {
          "x" : 1961,
          "y" : 948
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1964,
          "y" : 951
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1964,
          "y" : 951
        }
      }
    } ]
  }, {
    "id" : 881,
    "reactomeId" : 870499,
    "displayName" : "USP9X",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 640,
      "y" : 345
    },
    "minX" : 574,
    "maxX" : 681,
    "minY" : 310,
    "maxY" : 356,
    "prop" : {
      "x" : 610,
      "y" : 335,
      "width" : 61,
      "height" : 21
    },
    "textPosition" : {
      "x" : 616,
      "y" : 335
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 671,
          "y" : 335
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 671,
          "y" : 335
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 880,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 607,
          "y" : 346
        },
        "to" : {
          "x" : 574,
          "y" : 348
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 891,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 652,
          "y" : 332
        },
        "to" : {
          "x" : 681,
          "y" : 310
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 655,
          "y" : 325
        },
        "b" : {
          "x" : 652,
          "y" : 332
        },
        "c" : {
          "x" : 660,
          "y" : 331
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 660,
          "y" : 331
        }
      }
    } ]
  }, {
    "id" : 882,
    "reactomeId" : 870520,
    "displayName" : "Ub-SMAD4:USP9X",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 564,
      "y" : 264
    },
    "minX" : 525,
    "maxX" : 673,
    "minY" : 227,
    "maxY" : 284,
    "prop" : {
      "x" : 525,
      "y" : 246,
      "width" : 78,
      "height" : 36
    },
    "textPosition" : {
      "x" : 526,
      "y" : 247
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 603,
          "y" : 246
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 603,
          "y" : 246
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 880,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 891,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 606,
          "y" : 273
        },
        "to" : {
          "x" : 644,
          "y" : 284
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 891,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 606,
          "y" : 246
        },
        "to" : {
          "x" : 648,
          "y" : 227
        }
      }, {
        "from" : {
          "x" : 648,
          "y" : 227
        },
        "to" : {
          "x" : 667,
          "y" : 263
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 669,
          "y" : 266
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 669,
          "y" : 266
        }
      }
    } ]
  }, {
    "id" : 1395,
    "reactomeId" : 1980213,
    "displayName" : "COL1A2(23-1366)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 295,
      "y" : 1258
    },
    "minX" : 236,
    "maxX" : 361,
    "minY" : 1241,
    "maxY" : 1269,
    "prop" : {
      "x" : 236,
      "y" : 1247,
      "width" : 119,
      "height" : 22
    },
    "textPosition" : {
      "x" : 237,
      "y" : 1247
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 355,
          "y" : 1247
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 355,
          "y" : 1247
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1394,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 629,
    "reactomeId" : 2127254,
    "displayName" : "MYC gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 1237,
      "y" : 1300
    },
    "minX" : 1195,
    "maxX" : 1288,
    "minY" : 1228,
    "maxY" : 1326,
    "prop" : {
      "x" : 1195,
      "y" : 1275,
      "width" : 84,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1202,
      "y" : 1302
    },
    "connectors" : [ {
      "edgeId" : 1970,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1972,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1288,
          "y" : 1277
        },
        "to" : {
          "x" : 1280,
          "y" : 1228
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1286,
        "y" : 1273
      },
      "b" : {
        "x" : 1279,
        "y" : 1277
      },
      "c" : {
        "x" : 1286,
        "y" : 1281
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1286,
        "y" : 1281
      }
    }
  }, {
    "id" : 630,
    "reactomeId" : 188379,
    "displayName" : "MYC",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1527,
      "y" : 1280
    },
    "minX" : 1506,
    "maxX" : 1554,
    "minY" : 1263,
    "maxY" : 1291,
    "prop" : {
      "x" : 1506,
      "y" : 1269,
      "width" : 42,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1510,
      "y" : 1269
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1548,
          "y" : 1269
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1548,
          "y" : 1269
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1970,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1144,
    "reactomeId" : 2186778,
    "displayName" : "Ub-SMAD7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1974,
      "y" : 1004
    },
    "minX" : 1936,
    "maxX" : 2018,
    "minY" : 977,
    "maxY" : 1015,
    "prop" : {
      "x" : 1936,
      "y" : 993,
      "width" : 76,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1938,
      "y" : 994
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2012,
          "y" : 993
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2012,
          "y" : 993
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1165,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1143,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1973,
          "y" : 990
        },
        "to" : {
          "x" : 1972,
          "y" : 977
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1968,
          "y" : 983
        },
        "b" : {
          "x" : 1973,
          "y" : 990
        },
        "c" : {
          "x" : 1976,
          "y" : 983
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1976,
          "y" : 983
        }
      }
    } ]
  }, {
    "id" : 1146,
    "reactomeId" : 68524,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2025,
      "y" : 938
    },
    "minX" : 1972,
    "maxX" : 2057,
    "minY" : 928,
    "maxY" : 949,
    "prop" : {
      "x" : 1993,
      "y" : 928,
      "width" : 64,
      "height" : 21
    },
    "textPosition" : {
      "x" : 2012,
      "y" : 928
    },
    "connectors" : [ {
      "edgeId" : 1143,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1987,
          "y" : 939
        },
        "to" : {
          "x" : 1972,
          "y" : 941
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 892,
    "reactomeId" : 113595,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 700,
      "y" : 381
    },
    "minX" : 667,
    "maxX" : 733,
    "minY" : 310,
    "maxY" : 391,
    "prop" : {
      "x" : 667,
      "y" : 371,
      "width" : 66,
      "height" : 20
    },
    "textPosition" : {
      "x" : 687,
      "y" : 371
    },
    "connectors" : [ {
      "edgeId" : 891,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 697,
          "y" : 365
        },
        "to" : {
          "x" : 681,
          "y" : 310
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 691,
          "y" : 359
        },
        "b" : {
          "x" : 697,
          "y" : 365
        },
        "c" : {
          "x" : 699,
          "y" : 357
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 699,
          "y" : 357
        }
      }
    } ]
  }, {
    "id" : 893,
    "reactomeId" : 170862,
    "displayName" : "SMAD4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 743,
      "y" : 292
    },
    "minX" : 681,
    "maxX" : 811,
    "minY" : 259,
    "maxY" : 310,
    "prop" : {
      "x" : 718,
      "y" : 282,
      "width" : 50,
      "height" : 21
    },
    "textPosition" : {
      "x" : 721,
      "y" : 275
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 768,
          "y" : 282
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 768,
          "y" : 282
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1434,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 764,
          "y" : 279
        },
        "to" : {
          "x" : 811,
          "y" : 259
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 781,
            "y" : 263
          },
          "b" : {
            "x" : 793,
            "y" : 275
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 787,
            "y" : 269
          }
        }
      }
    }, {
      "edgeId" : 891,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 715,
          "y" : 299
        },
        "to" : {
          "x" : 681,
          "y" : 310
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 710,
          "y" : 305
        },
        "b" : {
          "x" : 715,
          "y" : 299
        },
        "c" : {
          "x" : 707,
          "y" : 297
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 707,
          "y" : 297
        }
      }
    } ]
  }, {
    "id" : 1405,
    "reactomeId" : 9733227,
    "displayName" : "p-S32,S36-YBX1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 809,
      "y" : 1364
    },
    "minX" : 679,
    "maxX" : 863,
    "minY" : 1339,
    "maxY" : 1383,
    "prop" : {
      "x" : 761,
      "y" : 1345,
      "width" : 96,
      "height" : 38
    },
    "innerProp" : {
      "x" : 767,
      "y" : 1345,
      "width" : 90,
      "height" : 38
    },
    "textPosition" : {
      "x" : 771,
      "y" : 1346
    },
    "nodeAttachments" : [ {
      "reactomeId" : 9736839,
      "label" : "P",
      "description" : "O-phospho-L-serine at 32",
      "shape" : {
        "a" : {
          "x" : 755,
          "y" : 1368
        },
        "b" : {
          "x" : 767,
          "y" : 1380
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 761,
          "y" : 1374
        }
      }
    }, {
      "reactomeId" : 9737526,
      "label" : "P",
      "description" : "O-phospho-L-serine at 36",
      "shape" : {
        "a" : {
          "x" : 755,
          "y" : 1353
        },
        "b" : {
          "x" : 767,
          "y" : 1365
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 761,
          "y" : 1359
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 857,
          "y" : 1345
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 857,
          "y" : 1345
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1404,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 758,
          "y" : 1357
        },
        "to" : {
          "x" : 679,
          "y" : 1347
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1406,
    "reactomeId" : 9733219,
    "displayName" : "p-2S-SMAD3:p-2S-SMAD3:SMAD4:p-S-YBX1:COL1A2 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 618,
      "y" : 1439
    },
    "minX" : 520,
    "maxX" : 723,
    "minY" : 1313,
    "maxY" : 1460,
    "prop" : {
      "x" : 520,
      "y" : 1418,
      "width" : 197,
      "height" : 42
    },
    "textPosition" : {
      "x" : 520,
      "y" : 1425
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 717,
          "y" : 1418
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 717,
          "y" : 1418
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1394,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 608,
          "y" : 1415
        },
        "to" : {
          "x" : 561,
          "y" : 1315
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 557,
          "y" : 1317
        },
        "b" : {
          "x" : 565,
          "y" : 1313
        },
        "c" : {
          "x" : 561,
          "y" : 1315
        },
        "type" : "STOP",
        "centre" : {
          "x" : 561,
          "y" : 1315
        }
      }
    }, {
      "edgeId" : 1404,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 895,
    "reactomeId" : 171182,
    "displayName" : "p-2S-SMAD2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 802,
      "y" : 186
    },
    "minX" : 751,
    "maxX" : 853,
    "minY" : 174,
    "maxY" : 259,
    "prop" : {
      "x" : 751,
      "y" : 174,
      "width" : 102,
      "height" : 24
    },
    "textPosition" : {
      "x" : 754,
      "y" : 175
    },
    "connectors" : [ {
      "edgeId" : 1434,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 803,
          "y" : 204
        },
        "to" : {
          "x" : 811,
          "y" : 259
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 801,
            "y" : 225
          },
          "b" : {
            "x" : 813,
            "y" : 237
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 807,
            "y" : 231
          }
        }
      }
    } ]
  }, {
    "id" : 1924,
    "reactomeId" : 9736977,
    "displayName" : "p-2S-SMAD2,3:SMAD4:SP1:CDKN2B gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 584,
      "y" : 860
    },
    "minX" : 509,
    "maxX" : 666,
    "minY" : 834,
    "maxY" : 941,
    "prop" : {
      "x" : 509,
      "y" : 840,
      "width" : 151,
      "height" : 40
    },
    "textPosition" : {
      "x" : 511,
      "y" : 845
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 660,
          "y" : 840
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 660,
          "y" : 840
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1923,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1925,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 571,
          "y" : 883
        },
        "to" : {
          "x" : 534,
          "y" : 941
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 534,
          "y" : 933
        },
        "b" : {
          "x" : 534,
          "y" : 941
        },
        "c" : {
          "x" : 541,
          "y" : 937
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 541,
          "y" : 937
        }
      }
    } ]
  }, {
    "id" : 918,
    "reactomeId" : 2186609,
    "displayName" : "TGIF",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1077,
      "y" : 767
    },
    "minX" : 1001,
    "maxX" : 1095,
    "minY" : 757,
    "maxY" : 778,
    "prop" : {
      "x" : 1059,
      "y" : 757,
      "width" : 36,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1060,
      "y" : 757
    },
    "connectors" : [ {
      "edgeId" : 861,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1053,
          "y" : 768
        },
        "to" : {
          "x" : 1001,
          "y" : 775
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1174,
    "reactomeId" : 173530,
    "displayName" : "Nuclear ubiquitin ligase",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 634,
      "y" : 758
    },
    "minX" : 579,
    "maxX" : 763,
    "minY" : 740,
    "maxY" : 776,
    "prop" : {
      "x" : 579,
      "y" : 740,
      "width" : 111,
      "height" : 36
    },
    "textPosition" : {
      "x" : 583,
      "y" : 740
    },
    "connectors" : [ {
      "edgeId" : 1173,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 696,
          "y" : 757
        },
        "to" : {
          "x" : 755,
          "y" : 756
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 759,
          "y" : 756
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 759,
          "y" : 756
        }
      }
    } ]
  }, {
    "id" : 662,
    "reactomeId" : 870522,
    "displayName" : "TRIM33",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 809,
      "y" : 544
    },
    "minX" : 698,
    "maxX" : 844,
    "minY" : 527,
    "maxY" : 642,
    "prop" : {
      "x" : 781,
      "y" : 533,
      "width" : 57,
      "height" : 22
    },
    "textPosition" : {
      "x" : 783,
      "y" : 533
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 838,
          "y" : 533
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 838,
          "y" : 533
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 661,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 809,
          "y" : 558
        },
        "to" : {
          "x" : 810,
          "y" : 642
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 869,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 778,
          "y" : 545
        },
        "to" : {
          "x" : 698,
          "y" : 548
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 771,
          "y" : 549
        },
        "b" : {
          "x" : 778,
          "y" : 545
        },
        "c" : {
          "x" : 771,
          "y" : 541
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 771,
          "y" : 541
        }
      }
    } ]
  }, {
    "id" : 663,
    "reactomeId" : 870446,
    "displayName" : "p-SMAD2,3:SMAD4:TRIM33",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 712,
      "y" : 668
    },
    "minX" : 659,
    "maxX" : 771,
    "minY" : 596,
    "maxY" : 686,
    "prop" : {
      "x" : 659,
      "y" : 650,
      "width" : 106,
      "height" : 36
    },
    "textPosition" : {
      "x" : 662,
      "y" : 651
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 765,
          "y" : 650
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 765,
          "y" : 650
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 661,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 869,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 711,
          "y" : 647
        },
        "to" : {
          "x" : 709,
          "y" : 601
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 869,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 739,
          "y" : 647
        },
        "to" : {
          "x" : 755,
          "y" : 640
        }
      }, {
        "from" : {
          "x" : 755,
          "y" : 640
        },
        "to" : {
          "x" : 733,
          "y" : 604
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 731,
          "y" : 600
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 731,
          "y" : 600
        }
      }
    } ]
  }, {
    "id" : 1176,
    "reactomeId" : 2187294,
    "displayName" : "JUNB gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 858,
      "y" : 1526
    },
    "minX" : 824,
    "maxX" : 916,
    "minY" : 1421,
    "maxY" : 1552,
    "prop" : {
      "x" : 824,
      "y" : 1501,
      "width" : 69,
      "height" : 51
    },
    "textPosition" : {
      "x" : 838,
      "y" : 1528
    },
    "connectors" : [ {
      "edgeId" : 2018,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 902,
          "y" : 1503
        },
        "to" : {
          "x" : 916,
          "y" : 1421
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2020,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 900,
        "y" : 1499
      },
      "b" : {
        "x" : 893,
        "y" : 1503
      },
      "c" : {
        "x" : 900,
        "y" : 1507
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 900,
        "y" : 1507
      }
    }
  }, {
    "id" : 1179,
    "reactomeId" : 2186795,
    "displayName" : "JUNB",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1211,
      "y" : 1494
    },
    "minX" : 1191,
    "maxX" : 1237,
    "minY" : 1476,
    "maxY" : 1506,
    "prop" : {
      "x" : 1191,
      "y" : 1482,
      "width" : 40,
      "height" : 24
    },
    "textPosition" : {
      "x" : 1192,
      "y" : 1483
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1231,
          "y" : 1482
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1231,
          "y" : 1482
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2020,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1435,
    "reactomeId" : 171175,
    "displayName" : "p-2S-SMAD2,3:SMAD4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 835,
      "y" : 359
    },
    "minX" : 784,
    "maxX" : 966,
    "minY" : 250,
    "maxY" : 377,
    "prop" : {
      "x" : 784,
      "y" : 341,
      "width" : 102,
      "height" : 36
    },
    "textPosition" : {
      "x" : 785,
      "y" : 341
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 1434,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1436,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1437,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 856,
          "y" : 335
        },
        "to" : {
          "x" : 966,
          "y" : 250
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1445,
    "reactomeId" : 173511,
    "displayName" : "p-2S-SMAD2,3:SMAD4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 888,
      "y" : 654
    },
    "minX" : 594,
    "maxX" : 1286,
    "minY" : 524,
    "maxY" : 1421,
    "prop" : {
      "x" : 835,
      "y" : 637,
      "width" : 107,
      "height" : 34
    },
    "textPosition" : {
      "x" : 839,
      "y" : 637
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 1026,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 902,
          "y" : 677
        },
        "to" : {
          "x" : 1117,
          "y" : 921
        }
      }, {
        "from" : {
          "x" : 1117,
          "y" : 921
        },
        "to" : {
          "x" : 1286,
          "y" : 1075
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 910,
          "y" : 680
        },
        "b" : {
          "x" : 902,
          "y" : 677
        },
        "c" : {
          "x" : 904,
          "y" : 685
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 904,
          "y" : 685
        }
      }
    }, {
      "edgeId" : 661,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 829,
          "y" : 645
        },
        "to" : {
          "x" : 810,
          "y" : 642
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1173,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1436,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 681,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 948,
          "y" : 654
        },
        "to" : {
          "x" : 958,
          "y" : 655
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1196,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 882,
          "y" : 677
        },
        "to" : {
          "x" : 774,
          "y" : 980
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 951,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 892,
          "y" : 677
        },
        "to" : {
          "x" : 946,
          "y" : 888
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1214,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 894,
          "y" : 631
        },
        "to" : {
          "x" : 913,
          "y" : 584
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 597,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 889,
          "y" : 677
        },
        "to" : {
          "x" : 949,
          "y" : 1196
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 861,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 903,
          "y" : 677
        },
        "to" : {
          "x" : 1001,
          "y" : 775
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 993,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 886,
          "y" : 677
        },
        "to" : {
          "x" : 863,
          "y" : 886
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2018,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 888,
          "y" : 677
        },
        "to" : {
          "x" : 916,
          "y" : 1421
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2038,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 839,
          "y" : 677
        },
        "to" : {
          "x" : 697,
          "y" : 721
        }
      }, {
        "from" : {
          "x" : 697,
          "y" : 721
        },
        "to" : {
          "x" : 594,
          "y" : 661
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 602,
          "y" : 661
        },
        "b" : {
          "x" : 594,
          "y" : 661
        },
        "c" : {
          "x" : 598,
          "y" : 668
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 598,
          "y" : 668
        }
      }
    }, {
      "edgeId" : 1271,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 887,
          "y" : 631
        },
        "to" : {
          "x" : 881,
          "y" : 524
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 682,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 953,
      "y" : 695
    },
    "minX" : 935,
    "maxX" : 972,
    "minY" : 655,
    "maxY" : 706,
    "prop" : {
      "x" : 935,
      "y" : 684,
      "width" : 36,
      "height" : 22
    },
    "textPosition" : {
      "x" : 937,
      "y" : 684
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 966,
          "y" : 689
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 966,
          "y" : 689
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 681,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 954,
          "y" : 681
        },
        "to" : {
          "x" : 958,
          "y" : 655
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 950,
            "y" : 662
          },
          "b" : {
            "x" : 962,
            "y" : 674
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 956,
            "y" : 668
          }
        }
      }
    } ]
  }, {
    "id" : 2219,
    "reactomeId" : 9773863,
    "displayName" : "Ub-SMAD4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 572,
      "y" : 531
    },
    "minX" : 515,
    "maxX" : 698,
    "minY" : 515,
    "maxY" : 548,
    "prop" : {
      "x" : 521,
      "y" : 521,
      "width" : 102,
      "height" : 21
    },
    "innerProp" : {
      "x" : 527,
      "y" : 521,
      "width" : 96,
      "height" : 21
    },
    "textPosition" : {
      "x" : 536,
      "y" : 521
    },
    "nodeAttachments" : [ {
      "reactomeId" : 9773862,
      "label" : "U",
      "description" : "ubiquitinylated lysine (Ub [nucleoplasm]) at unknown position",
      "shape" : {
        "a" : {
          "x" : 515,
          "y" : 524
        },
        "b" : {
          "x" : 527,
          "y" : 536
        },
        "s" : "U",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 521,
          "y" : 530
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 623,
          "y" : 521
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 623,
          "y" : 521
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 869,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 626,
          "y" : 537
        },
        "to" : {
          "x" : 698,
          "y" : 548
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 656,
            "y" : 536
          },
          "b" : {
            "x" : 668,
            "y" : 548
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 662,
            "y" : 542
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 633,
          "y" : 534
        },
        "b" : {
          "x" : 626,
          "y" : 537
        },
        "c" : {
          "x" : 632,
          "y" : 542
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 632,
          "y" : 542
        }
      }
    }, {
      "edgeId" : 874,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2220,
    "reactomeId" : 9773859,
    "displayName" : "Ub-SMAD4",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 547,
      "y" : 384
    },
    "minX" : 494,
    "maxX" : 600,
    "minY" : 348,
    "maxY" : 396,
    "prop" : {
      "x" : 500,
      "y" : 373,
      "width" : 94,
      "height" : 23
    },
    "innerProp" : {
      "x" : 506,
      "y" : 373,
      "width" : 88,
      "height" : 23
    },
    "textPosition" : {
      "x" : 511,
      "y" : 374
    },
    "nodeAttachments" : [ {
      "reactomeId" : 9773861,
      "label" : "U",
      "description" : "ubiquitinylated lysine (Ub [cytosol]) at unknown position",
      "shape" : {
        "a" : {
          "x" : 494,
          "y" : 374
        },
        "b" : {
          "x" : 506,
          "y" : 386
        },
        "s" : "U",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 500,
          "y" : 380
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 594,
          "y" : 373
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 594,
          "y" : 373
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 874,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 880,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 555,
          "y" : 370
        },
        "to" : {
          "x" : 574,
          "y" : 348
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1197,
    "reactomeId" : 1592223,
    "displayName" : "SP1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 654,
      "y" : 1054
    },
    "minX" : 639,
    "maxX" : 774,
    "minY" : 980,
    "maxY" : 1163,
    "prop" : {
      "x" : 639,
      "y" : 1043,
      "width" : 30,
      "height" : 22
    },
    "textPosition" : {
      "x" : 642,
      "y" : 1037
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 669,
          "y" : 1043
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 669,
          "y" : 1043
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1196,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 672,
          "y" : 1044
        },
        "to" : {
          "x" : 774,
          "y" : 980
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1361,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 663,
          "y" : 1068
        },
        "to" : {
          "x" : 745,
          "y" : 1163
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1198,
    "reactomeId" : 2187302,
    "displayName" : "p-2S-SMAD2,3:SMAD4:SP1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 749,
      "y" : 865
    },
    "minX" : 679,
    "maxX" : 807,
    "minY" : 841,
    "maxY" : 964,
    "prop" : {
      "x" : 697,
      "y" : 847,
      "width" : 104,
      "height" : 36
    },
    "textPosition" : {
      "x" : 699,
      "y" : 848
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 801,
          "y" : 847
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 801,
          "y" : 847
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1923,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 736,
          "y" : 886
        },
        "to" : {
          "x" : 679,
          "y" : 964
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1196,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1710,
    "reactomeId" : 9736958,
    "displayName" : "WWTR1:p-2S-SMAD2,3:SMAD4:SERPINE1 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1671,
      "y" : 1078
    },
    "minX" : 1569,
    "maxX" : 1733,
    "minY" : 1047,
    "maxY" : 1103,
    "prop" : {
      "x" : 1616,
      "y" : 1053,
      "width" : 111,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1619,
      "y" : 1040
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1727,
          "y" : 1053
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1727,
          "y" : 1053
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1709,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1716,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1613,
          "y" : 1075
        },
        "to" : {
          "x" : 1569,
          "y" : 1073
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1576,
          "y" : 1069
        },
        "b" : {
          "x" : 1569,
          "y" : 1073
        },
        "c" : {
          "x" : 1576,
          "y" : 1077
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1576,
          "y" : 1077
        }
      }
    } ]
  }, {
    "id" : 687,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1018,
      "y" : 699
    },
    "minX" : 992,
    "maxX" : 1037,
    "minY" : 656,
    "maxY" : 710,
    "prop" : {
      "x" : 1001,
      "y" : 688,
      "width" : 35,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1002,
      "y" : 688
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1031,
          "y" : 693
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1031,
          "y" : 693
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 681,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1011,
          "y" : 685
        },
        "to" : {
          "x" : 992,
          "y" : 656
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 995,
            "y" : 664
          },
          "b" : {
            "x" : 1007,
            "y" : 676
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1001,
            "y" : 670
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1004,
          "y" : 681
        },
        "b" : {
          "x" : 1011,
          "y" : 685
        },
        "c" : {
          "x" : 1011,
          "y" : 677
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1011,
          "y" : 677
        }
      }
    } ]
  }, {
    "id" : 690,
    "reactomeId" : 2176485,
    "displayName" : "CDK8:CCNC/ CDK9:CCNT",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 975,
      "y" : 604
    },
    "minX" : 930,
    "maxX" : 1020,
    "minY" : 586,
    "maxY" : 648,
    "prop" : {
      "x" : 930,
      "y" : 586,
      "width" : 90,
      "height" : 37
    },
    "textPosition" : {
      "x" : 932,
      "y" : 587
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 681,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 975,
          "y" : 629
        },
        "to" : {
          "x" : 975,
          "y" : 640
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 975,
          "y" : 644
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 975,
          "y" : 644
        }
      }
    } ]
  }, {
    "id" : 1971,
    "reactomeId" : 9736985,
    "displayName" : "p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2:MYC gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1435,
      "y" : 1187
    },
    "minX" : 1361,
    "maxX" : 1516,
    "minY" : 1157,
    "maxY" : 1268,
    "prop" : {
      "x" : 1361,
      "y" : 1163,
      "width" : 149,
      "height" : 49
    },
    "textPosition" : {
      "x" : 1362,
      "y" : 1163
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1510,
          "y" : 1163
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1510,
          "y" : 1163
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1970,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1435,
          "y" : 1215
        },
        "to" : {
          "x" : 1435,
          "y" : 1268
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1431,
          "y" : 1268
        },
        "b" : {
          "x" : 1439,
          "y" : 1268
        },
        "c" : {
          "x" : 1435,
          "y" : 1268
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1435,
          "y" : 1268
        }
      }
    }, {
      "edgeId" : 1972,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1204,
    "reactomeId" : 2187305,
    "displayName" : "CDKN2B gene",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Gene",
    "position" : {
      "x" : 568,
      "y" : 1005
    },
    "minX" : 521,
    "maxX" : 679,
    "minY" : 964,
    "maxY" : 1031,
    "prop" : {
      "x" : 521,
      "y" : 980,
      "width" : 95,
      "height" : 51
    },
    "textPosition" : {
      "x" : 522,
      "y" : 1007
    },
    "connectors" : [ {
      "edgeId" : 1923,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 625,
          "y" : 982
        },
        "to" : {
          "x" : 679,
          "y" : 964
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1925,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 623,
        "y" : 978
      },
      "b" : {
        "x" : 616,
        "y" : 982
      },
      "c" : {
        "x" : 623,
        "y" : 986
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 623,
        "y" : 986
      }
    }
  }, {
    "id" : 1205,
    "reactomeId" : 182586,
    "displayName" : "CDKN2B",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 388,
      "y" : 1003
    },
    "minX" : 348,
    "maxX" : 434,
    "minY" : 987,
    "maxY" : 1013,
    "prop" : {
      "x" : 348,
      "y" : 993,
      "width" : 80,
      "height" : 20
    },
    "textPosition" : {
      "x" : 359,
      "y" : 993
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 428,
          "y" : 993
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 428,
          "y" : 993
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1925,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 952,
    "reactomeId" : 2186620,
    "displayName" : "SKI/SKIL",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 979,
      "y" : 832
    },
    "minX" : 946,
    "maxX" : 1008,
    "minY" : 820,
    "maxY" : 888,
    "prop" : {
      "x" : 951,
      "y" : 820,
      "width" : 57,
      "height" : 24
    },
    "textPosition" : {
      "x" : 952,
      "y" : 821
    },
    "connectors" : [ {
      "edgeId" : 951,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 971,
          "y" : 850
        },
        "to" : {
          "x" : 946,
          "y" : 888
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 953,
    "reactomeId" : 349716,
    "displayName" : "NCOR1, NCOR2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1033,
      "y" : 887
    },
    "minX" : 946,
    "maxX" : 1286,
    "minY" : 873,
    "maxY" : 1075,
    "prop" : {
      "x" : 1001,
      "y" : 873,
      "width" : 65,
      "height" : 28
    },
    "textPosition" : {
      "x" : 1004,
      "y" : 870
    },
    "connectors" : [ {
      "edgeId" : 1026,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1051,
          "y" : 907
        },
        "to" : {
          "x" : 1286,
          "y" : 1075
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1059,
          "y" : 908
        },
        "b" : {
          "x" : 1051,
          "y" : 907
        },
        "c" : {
          "x" : 1054,
          "y" : 914
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1054,
          "y" : 914
        }
      }
    }, {
      "edgeId" : 951,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 995,
          "y" : 887
        },
        "to" : {
          "x" : 946,
          "y" : 888
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 954,
    "reactomeId" : 177110,
    "displayName" : "p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1036,
      "y" : 977
    },
    "minX" : 961,
    "maxX" : 1117,
    "minY" : 953,
    "maxY" : 1026,
    "prop" : {
      "x" : 961,
      "y" : 959,
      "width" : 150,
      "height" : 36
    },
    "textPosition" : {
      "x" : 963,
      "y" : 960
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1111,
          "y" : 959
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1111,
          "y" : 959
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 951,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1015,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1036,
          "y" : 998
        },
        "to" : {
          "x" : 1037,
          "y" : 1026
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1215,
    "reactomeId" : 201568,
    "displayName" : "PARP1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 933,
      "y" : 534
    },
    "minX" : 907,
    "maxX" : 1175,
    "minY" : 506,
    "maxY" : 584,
    "prop" : {
      "x" : 907,
      "y" : 523,
      "width" : 53,
      "height" : 22
    },
    "textPosition" : {
      "x" : 909,
      "y" : 523
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 960,
          "y" : 523
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 960,
          "y" : 523
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1214,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 928,
          "y" : 548
        },
        "to" : {
          "x" : 913,
          "y" : 584
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1239,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 963,
          "y" : 529
        },
        "to" : {
          "x" : 1110,
          "y" : 506
        }
      }, {
        "from" : {
          "x" : 1110,
          "y" : 506
        },
        "to" : {
          "x" : 1175,
          "y" : 548
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 969,
          "y" : 524
        },
        "b" : {
          "x" : 963,
          "y" : 529
        },
        "c" : {
          "x" : 970,
          "y" : 532
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 970,
          "y" : 532
        }
      }
    } ]
  }, {
    "id" : 1216,
    "reactomeId" : 2187322,
    "displayName" : "p-2S-SMAD2,3:SMAD4:PARP1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1027,
      "y" : 559
    },
    "minX" : 976,
    "maxX" : 1145,
    "minY" : 524,
    "maxY" : 577,
    "prop" : {
      "x" : 976,
      "y" : 542,
      "width" : 103,
      "height" : 35
    },
    "textPosition" : {
      "x" : 978,
      "y" : 542
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1079,
          "y" : 542
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1079,
          "y" : 542
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1214,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1239,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1082,
          "y" : 552
        },
        "to" : {
          "x" : 1119,
          "y" : 548
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1239,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1075,
          "y" : 539
        },
        "to" : {
          "x" : 1123,
          "y" : 524
        }
      }, {
        "from" : {
          "x" : 1123,
          "y" : 524
        },
        "to" : {
          "x" : 1138,
          "y" : 538
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1141,
          "y" : 541
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1141,
          "y" : 541
        }
      }
    } ]
  }, {
    "id" : 712,
    "reactomeId" : 2176420,
    "displayName" : "NEDD4L",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1157,
      "y" : 610
    },
    "minX" : 1129,
    "maxX" : 1358,
    "minY" : 594,
    "maxY" : 647,
    "prop" : {
      "x" : 1129,
      "y" : 600,
      "width" : 57,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1129,
      "y" : 600
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1186,
          "y" : 600
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1186,
          "y" : 600
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 711,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1156,
          "y" : 624
        },
        "to" : {
          "x" : 1154,
          "y" : 647
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 744,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1189,
          "y" : 609
        },
        "to" : {
          "x" : 1349,
          "y" : 606
        }
      }, {
        "from" : {
          "x" : 1349,
          "y" : 606
        },
        "to" : {
          "x" : 1358,
          "y" : 642
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1196,
          "y" : 605
        },
        "b" : {
          "x" : 1189,
          "y" : 609
        },
        "c" : {
          "x" : 1196,
          "y" : 613
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1196,
          "y" : 613
        }
      }
    } ]
  }, {
    "id" : 713,
    "reactomeId" : 2176495,
    "displayName" : "p-T-2S-SMAD2,3:SMAD4:NEDDL4",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1249,
      "y" : 646
    },
    "minX" : 1190,
    "maxX" : 1326,
    "minY" : 622,
    "maxY" : 664,
    "prop" : {
      "x" : 1190,
      "y" : 628,
      "width" : 118,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1194,
      "y" : 629
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1308,
          "y" : 628
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1308,
          "y" : 628
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 711,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 744,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1311,
          "y" : 643
        },
        "to" : {
          "x" : 1326,
          "y" : 643
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1240,
    "reactomeId" : 427523,
    "displayName" : "NAD+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1120,
      "y" : 578
    },
    "minX" : 1094,
    "maxX" : 1147,
    "minY" : 548,
    "maxY" : 590,
    "prop" : {
      "x" : 1094,
      "y" : 567,
      "width" : 52,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1098,
      "y" : 568
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1141,
          "y" : 572
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1141,
          "y" : 572
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1239,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1119,
          "y" : 564
        },
        "to" : {
          "x" : 1119,
          "y" : 548
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1242,
    "reactomeId" : 427497,
    "displayName" : "NAM",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1214,
      "y" : 583
    },
    "minX" : 1175,
    "maxX" : 1245,
    "minY" : 548,
    "maxY" : 594,
    "prop" : {
      "x" : 1185,
      "y" : 573,
      "width" : 59,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1197,
      "y" : 573
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1239,
          "y" : 578
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1239,
          "y" : 578
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1239,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1202,
          "y" : 570
        },
        "to" : {
          "x" : 1175,
          "y" : 548
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1194,
          "y" : 569
        },
        "b" : {
          "x" : 1202,
          "y" : 570
        },
        "c" : {
          "x" : 1199,
          "y" : 563
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1199,
          "y" : 563
        }
      }
    } ]
  }, {
    "id" : 1756,
    "reactomeId" : 9736963,
    "displayName" : "SMAD7:SERPINE1 gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1710,
      "y" : 898
    },
    "minX" : 1619,
    "maxX" : 1766,
    "minY" : 874,
    "maxY" : 925,
    "prop" : {
      "x" : 1660,
      "y" : 880,
      "width" : 100,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1674,
      "y" : 867
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1760,
          "y" : 880
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1760,
          "y" : 880
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1709,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1657,
          "y" : 910
        },
        "to" : {
          "x" : 1620,
          "y" : 921
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1619,
          "y" : 917
        },
        "b" : {
          "x" : 1621,
          "y" : 925
        },
        "c" : {
          "x" : 1620,
          "y" : 921
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1620,
          "y" : 921
        }
      }
    }, {
      "edgeId" : 1755,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 994,
    "reactomeId" : 2186626,
    "displayName" : "MEN1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 870,
      "y" : 975
    },
    "minX" : 847,
    "maxX" : 900,
    "minY" : 886,
    "maxY" : 986,
    "prop" : {
      "x" : 847,
      "y" : 964,
      "width" : 47,
      "height" : 22
    },
    "textPosition" : {
      "x" : 849,
      "y" : 964
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 894,
          "y" : 964
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 894,
          "y" : 964
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 993,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 869,
          "y" : 961
        },
        "to" : {
          "x" : 863,
          "y" : 886
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 995,
    "reactomeId" : 2186642,
    "displayName" : "p-2S-SMAD2,3:SMAD4:MEN1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 844,
      "y" : 1153
    },
    "minX" : 792,
    "maxX" : 902,
    "minY" : 1129,
    "maxY" : 1171,
    "prop" : {
      "x" : 792,
      "y" : 1135,
      "width" : 104,
      "height" : 36
    },
    "textPosition" : {
      "x" : 794,
      "y" : 1136
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 896,
          "y" : 1135
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 896,
          "y" : 1135
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 993,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2019,
    "reactomeId" : 9736993,
    "displayName" : "p-2S-SMAD2,3:SMAD4:JUNB gene",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1073,
      "y" : 1435
    },
    "minX" : 1016,
    "maxX" : 1136,
    "minY" : 1411,
    "maxY" : 1505,
    "prop" : {
      "x" : 1016,
      "y" : 1417,
      "width" : 114,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1023,
      "y" : 1404
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1130,
          "y" : 1417
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1130,
          "y" : 1417
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 2018,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 2020,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1073,
          "y" : 1456
        },
        "to" : {
          "x" : 1074,
          "y" : 1505
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1070,
          "y" : 1498
        },
        "b" : {
          "x" : 1074,
          "y" : 1505
        },
        "c" : {
          "x" : 1078,
          "y" : 1498
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1078,
          "y" : 1498
        }
      }
    } ]
  }, {
    "id" : 745,
    "reactomeId" : 68524,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1305,
      "y" : 700
    },
    "minX" : 1273,
    "maxX" : 1337,
    "minY" : 643,
    "maxY" : 754,
    "prop" : {
      "x" : 1273,
      "y" : 690,
      "width" : 64,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1292,
      "y" : 690
    },
    "connectors" : [ {
      "edgeId" : 838,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1303,
          "y" : 717
        },
        "to" : {
          "x" : 1296,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 1293,
            "y" : 729
          },
          "b" : {
            "x" : 1305,
            "y" : 741
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1299,
            "y" : 735
          }
        }
      }
    }, {
      "edgeId" : 744,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1308,
          "y" : 684
        },
        "to" : {
          "x" : 1326,
          "y" : 643
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1311,
            "y" : 657
          },
          "b" : {
            "x" : 1323,
            "y" : 669
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1317,
            "y" : 663
          }
        }
      }
    } ]
  }, {
    "id" : 1002,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 604,
      "y" : 309
    },
    "minX" : 584,
    "maxX" : 644,
    "minY" : 284,
    "maxY" : 322,
    "prop" : {
      "x" : 584,
      "y" : 297,
      "width" : 40,
      "height" : 25
    },
    "textPosition" : {
      "x" : 587,
      "y" : 299
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 619,
          "y" : 302
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 619,
          "y" : 302
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 891,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 624,
          "y" : 294
        },
        "to" : {
          "x" : 644,
          "y" : 284
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 746,
    "reactomeId" : 2176504,
    "displayName" : "Ub-p-T-2S-SMAD2,3:SMAD4",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1429,
      "y" : 648
    },
    "minX" : 1358,
    "maxX" : 1479,
    "minY" : 617,
    "maxY" : 674,
    "prop" : {
      "x" : 1385,
      "y" : 623,
      "width" : 88,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1393,
      "y" : 625
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1473,
          "y" : 623
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1473,
          "y" : 623
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 744,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1382,
          "y" : 644
        },
        "to" : {
          "x" : 1358,
          "y" : 642
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1375,
          "y" : 647
        },
        "b" : {
          "x" : 1382,
          "y" : 644
        },
        "c" : {
          "x" : 1375,
          "y" : 639
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1375,
          "y" : 639
        }
      }
    }, {
      "edgeId" : 755,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 760,
    "reactomeId" : 178202,
    "displayName" : "SMURF2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1077,
      "y" : 717
    },
    "minX" : 1050,
    "maxX" : 1350,
    "minY" : 696,
    "maxY" : 802,
    "prop" : {
      "x" : 1050,
      "y" : 706,
      "width" : 55,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1052,
      "y" : 700
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1105,
          "y" : 706
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1105,
          "y" : 706
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 838,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1089,
          "y" : 731
        },
        "to" : {
          "x" : 1160,
          "y" : 790
        }
      }, {
        "from" : {
          "x" : 1160,
          "y" : 790
        },
        "to" : {
          "x" : 1350,
          "y" : 802
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1097,
          "y" : 732
        },
        "b" : {
          "x" : 1089,
          "y" : 731
        },
        "c" : {
          "x" : 1092,
          "y" : 739
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1092,
          "y" : 739
        }
      }
    }, {
      "edgeId" : 759,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1108,
          "y" : 707
        },
        "to" : {
          "x" : 1141,
          "y" : 696
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2040,
    "reactomeId" : 158797,
    "displayName" : "SERPINE1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1638,
      "y" : 1738
    },
    "minX" : 1606,
    "maxX" : 1676,
    "minY" : 1721,
    "maxY" : 1750,
    "prop" : {
      "x" : 1606,
      "y" : 1727,
      "width" : 64,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1608,
      "y" : 1721
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1670,
          "y" : 1727
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1670,
          "y" : 1727
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1716,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1016,
    "reactomeId" : 2186743,
    "displayName" : "RNF111/SMURF2",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 981,
      "y" : 1038
    },
    "minX" : 949,
    "maxX" : 1286,
    "minY" : 1018,
    "maxY" : 1159,
    "prop" : {
      "x" : 949,
      "y" : 1018,
      "width" : 65,
      "height" : 41
    },
    "textPosition" : {
      "x" : 951,
      "y" : 1021
    },
    "connectors" : [ {
      "edgeId" : 1026,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 985,
          "y" : 1065
        },
        "to" : {
          "x" : 1010,
          "y" : 1157
        }
      }, {
        "from" : {
          "x" : 1010,
          "y" : 1157
        },
        "to" : {
          "x" : 1279,
          "y" : 1159
        }
      }, {
        "from" : {
          "x" : 1279,
          "y" : 1159
        },
        "to" : {
          "x" : 1286,
          "y" : 1075
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 991,
          "y" : 1071
        },
        "b" : {
          "x" : 985,
          "y" : 1065
        },
        "c" : {
          "x" : 983,
          "y" : 1073
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 983,
          "y" : 1073
        }
      }
    }, {
      "edgeId" : 1015,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1020,
          "y" : 1031
        },
        "to" : {
          "x" : 1037,
          "y" : 1026
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1272,
    "reactomeId" : 205813,
    "displayName" : "PPM1A",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 950,
      "y" : 500
    },
    "minX" : 881,
    "maxX" : 1250,
    "minY" : 483,
    "maxY" : 524,
    "prop" : {
      "x" : 926,
      "y" : 489,
      "width" : 49,
      "height" : 22
    },
    "textPosition" : {
      "x" : 929,
      "y" : 483
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 975,
          "y" : 489
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 975,
          "y" : 489
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1271,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 923,
          "y" : 508
        },
        "to" : {
          "x" : 881,
          "y" : 524
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1276,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 978,
          "y" : 500
        },
        "to" : {
          "x" : 1250,
          "y" : 505
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 985,
          "y" : 496
        },
        "b" : {
          "x" : 978,
          "y" : 500
        },
        "c" : {
          "x" : 985,
          "y" : 504
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 985,
          "y" : 504
        }
      }
    } ]
  }, {
    "id" : 1273,
    "reactomeId" : 2187392,
    "displayName" : "p-2S-SMAD2,3:SMAD4:PPM1A",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 933,
      "y" : 460
    },
    "minX" : 882,
    "maxX" : 1088,
    "minY" : 432,
    "maxY" : 478,
    "prop" : {
      "x" : 882,
      "y" : 443,
      "width" : 103,
      "height" : 35
    },
    "textPosition" : {
      "x" : 884,
      "y" : 443
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 985,
          "y" : 443
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 985,
          "y" : 443
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1271,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1276,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 988,
          "y" : 456
        },
        "to" : {
          "x" : 1058,
          "y" : 451
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1276,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 988,
          "y" : 448
        },
        "to" : {
          "x" : 1060,
          "y" : 432
        }
      }, {
        "from" : {
          "x" : 1060,
          "y" : 432
        },
        "to" : {
          "x" : 1080,
          "y" : 445
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1084,
          "y" : 447
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1084,
          "y" : 447
        }
      }
    } ]
  }, {
    "id" : 1017,
    "reactomeId" : 2186744,
    "displayName" : "p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1118,
      "y" : 1068
    },
    "minX" : 1044,
    "maxX" : 1242,
    "minY" : 1037,
    "maxY" : 1094,
    "prop" : {
      "x" : 1044,
      "y" : 1043,
      "width" : 148,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1045,
      "y" : 1045
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1192,
          "y" : 1043
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1192,
          "y" : 1043
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1026,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1195,
          "y" : 1081
        },
        "to" : {
          "x" : 1230,
          "y" : 1088
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1026,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1195,
          "y" : 1051
        },
        "to" : {
          "x" : 1214,
          "y" : 1047
        }
      }, {
        "from" : {
          "x" : 1214,
          "y" : 1047
        },
        "to" : {
          "x" : 1234,
          "y" : 1063
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1238,
          "y" : 1066
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1238,
          "y" : 1066
        }
      }
    }, {
      "edgeId" : 1015,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 761,
    "reactomeId" : 2179277,
    "displayName" : "p-T-2S-SMAD2,3:SMAD4:SMURF2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1209,
      "y" : 745
    },
    "minX" : 1150,
    "maxX" : 1335,
    "minY" : 722,
    "maxY" : 783,
    "prop" : {
      "x" : 1150,
      "y" : 728,
      "width" : 119,
      "height" : 34
    },
    "textPosition" : {
      "x" : 1154,
      "y" : 727
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1269,
          "y" : 728
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1269,
          "y" : 728
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 838,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1272,
          "y" : 751
        },
        "to" : {
          "x" : 1296,
          "y" : 754
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 838,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1247,
          "y" : 765
        },
        "to" : {
          "x" : 1294,
          "y" : 783
        }
      }, {
        "from" : {
          "x" : 1294,
          "y" : 783
        },
        "to" : {
          "x" : 1327,
          "y" : 762
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1331,
          "y" : 760
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1331,
          "y" : 760
        }
      }
    }, {
      "edgeId" : 759,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2041,
    "reactomeId" : 877300,
    "displayName" : "Interferon gamma signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1563,
      "y" : 198
    },
    "minX" : 1466,
    "maxX" : 1661,
    "minY" : 173,
    "maxY" : 224,
    "prop" : {
      "x" : 1466,
      "y" : 173,
      "width" : 195,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1469,
      "y" : 184
    },
    "connectors" : [ ]
  }, {
    "id" : 2044,
    "reactomeId" : 9694516,
    "displayName" : "SARS-CoV-2 Infection",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 486,
      "y" : 26
    },
    "isDisease" : true,
    "minX" : 400,
    "maxX" : 573,
    "minY" : 0,
    "maxY" : 52,
    "prop" : {
      "x" : 400,
      "y" : 0,
      "width" : 173,
      "height" : 52
    },
    "textPosition" : {
      "x" : 413,
      "y" : 11
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 204
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ ]
  }, {
    "id" : 1277,
    "reactomeId" : 113518,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1089,
      "y" : 486
    },
    "minX" : 1058,
    "maxX" : 1111,
    "minY" : 451,
    "maxY" : 498,
    "prop" : {
      "x" : 1069,
      "y" : 475,
      "width" : 41,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1072,
      "y" : 476
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1105,
          "y" : 480
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1105,
          "y" : 480
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1276,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1078,
          "y" : 472
        },
        "to" : {
          "x" : 1058,
          "y" : 451
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1062,
            "y" : 455
          },
          "b" : {
            "x" : 1074,
            "y" : 467
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1068,
            "y" : 461
          }
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 1278,
    "reactomeId" : 2187387,
    "displayName" : "SMAD2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1359,
      "y" : 468
    },
    "minX" : 1250,
    "maxX" : 1392,
    "minY" : 457,
    "maxY" : 505,
    "prop" : {
      "x" : 1327,
      "y" : 457,
      "width" : 65,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1328,
      "y" : 457
    },
    "connectors" : [ {
      "edgeId" : 1282,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1276,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1321,
          "y" : 479
        },
        "to" : {
          "x" : 1250,
          "y" : 505
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1279,
            "y" : 486
          },
          "b" : {
            "x" : 1291,
            "y" : 498
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1285,
            "y" : 492
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1316,
          "y" : 485
        },
        "b" : {
          "x" : 1321,
          "y" : 479
        },
        "c" : {
          "x" : 1313,
          "y" : 478
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1313,
          "y" : 478
        }
      }
    } ]
  }, {
    "id" : 1279,
    "reactomeId" : 113550,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1430,
      "y" : 512
    },
    "minX" : 1250,
    "maxX" : 1447,
    "minY" : 498,
    "maxY" : 525,
    "prop" : {
      "x" : 1415,
      "y" : 499,
      "width" : 31,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1421,
      "y" : 501
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1441,
          "y" : 504
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1441,
          "y" : 504
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1276,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1412,
          "y" : 511
        },
        "to" : {
          "x" : 1250,
          "y" : 505
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1325,
            "y" : 502
          },
          "b" : {
            "x" : 1337,
            "y" : 514
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1331,
            "y" : 508
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1405,
          "y" : 515
        },
        "b" : {
          "x" : 1412,
          "y" : 511
        },
        "c" : {
          "x" : 1405,
          "y" : 507
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1405,
          "y" : 507
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 1282,
    "reactomeId" : 2187395,
    "displayName" : "Dephosphorylated SMAD2/3 translocates to the cytosol",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1356,
      "y" : 428
    },
    "minX" : 1350,
    "maxX" : 1362,
    "minY" : 375,
    "maxY" : 451,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1358,
        "y" : 451
      },
      "to" : {
        "x" : 1356,
        "y" : 428
      }
    }, {
      "from" : {
        "x" : 1356,
        "y" : 428
      },
      "to" : {
        "x" : 1355,
        "y" : 375
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1359,
        "y" : 382
      },
      "b" : {
        "x" : 1355,
        "y" : 375
      },
      "c" : {
        "x" : 1351,
        "y" : 382
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1351,
        "y" : 382
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1350,
        "y" : 422
      },
      "b" : {
        "x" : 1362,
        "y" : 434
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1356,
        "y" : 428
      }
    },
    "inputs" : [ {
      "id" : 1278
    } ],
    "outputs" : [ {
      "id" : 1283
    } ]
  }, {
    "id" : 1026,
    "reactomeId" : 2186747,
    "displayName" : "Ubiquitination of SKI/SKIL by RNF111/SMURF2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1247,
      "y" : 1073
    },
    "minX" : 1230,
    "maxX" : 1286,
    "minY" : 1067,
    "maxY" : 1088,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1230,
        "y" : 1088
      },
      "to" : {
        "x" : 1247,
        "y" : 1073
      }
    }, {
      "from" : {
        "x" : 1247,
        "y" : 1073
      },
      "to" : {
        "x" : 1286,
        "y" : 1075
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1241,
        "y" : 1067
      },
      "b" : {
        "x" : 1253,
        "y" : 1079
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1247,
        "y" : 1073
      }
    },
    "inputs" : [ {
      "id" : 1017,
      "points" : [ {
        "x" : 1195,
        "y" : 1081
      } ]
    }, {
      "id" : 1029,
      "points" : [ {
        "x" : 1223,
        "y" : 1104
      } ]
    } ],
    "outputs" : [ {
      "id" : 953,
      "points" : [ {
        "x" : 1051,
        "y" : 907
      } ]
    }, {
      "id" : 1016,
      "points" : [ {
        "x" : 985,
        "y" : 1065
      }, {
        "x" : 1010,
        "y" : 1157
      }, {
        "x" : 1279,
        "y" : 1159
      } ]
    }, {
      "id" : 1027,
      "points" : [ {
        "x" : 1322,
        "y" : 1070
      } ]
    }, {
      "id" : 1445,
      "points" : [ {
        "x" : 902,
        "y" : 677
      }, {
        "x" : 1117,
        "y" : 921
      } ]
    } ],
    "catalysts" : [ {
      "id" : 1017,
      "points" : [ {
        "x" : 1195,
        "y" : 1051
      }, {
        "x" : 1214,
        "y" : 1047
      } ]
    } ]
  }, {
    "id" : 1923,
    "reactomeId" : 9736979,
    "displayName" : "p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 642,
      "y" : 922
    },
    "minX" : 602,
    "maxX" : 679,
    "minY" : 883,
    "maxY" : 964,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 679,
        "y" : 964
      },
      "to" : {
        "x" : 642,
        "y" : 922
      }
    }, {
      "from" : {
        "x" : 642,
        "y" : 922
      },
      "to" : {
        "x" : 602,
        "y" : 883
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 610,
        "y" : 885
      },
      "b" : {
        "x" : 602,
        "y" : 883
      },
      "c" : {
        "x" : 604,
        "y" : 891
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 604,
        "y" : 891
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 642,
        "y" : 922
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 642,
        "y" : 922
      }
    },
    "inputs" : [ {
      "id" : 1198,
      "points" : [ {
        "x" : 736,
        "y" : 886
      } ]
    }, {
      "id" : 1204,
      "points" : [ {
        "x" : 625,
        "y" : 982
      } ]
    } ],
    "outputs" : [ {
      "id" : 1924
    } ]
  }, {
    "id" : 1925,
    "reactomeId" : 2187303,
    "displayName" : "SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 529,
      "y" : 949
    },
    "minX" : 414,
    "maxX" : 625,
    "minY" : 943,
    "maxY" : 990,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 625,
        "y" : 982
      },
      "to" : {
        "x" : 529,
        "y" : 949
      }
    }, {
      "from" : {
        "x" : 529,
        "y" : 949
      },
      "to" : {
        "x" : 414,
        "y" : 990
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 419,
        "y" : 984
      },
      "b" : {
        "x" : 414,
        "y" : 990
      },
      "c" : {
        "x" : 422,
        "y" : 991
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 422,
        "y" : 991
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 523,
        "y" : 943
      },
      "b" : {
        "x" : 535,
        "y" : 955
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 529,
        "y" : 949
      }
    },
    "inputs" : [ {
      "id" : 1204
    } ],
    "outputs" : [ {
      "id" : 1205
    } ],
    "activators" : [ {
      "id" : 1924,
      "points" : [ {
        "x" : 571,
        "y" : 883
      } ]
    } ]
  }, {
    "id" : 1165,
    "reactomeId" : 2186780,
    "displayName" : "Degradation of Ub-SMAD7",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1972,
      "y" : 1032
    },
    "minX" : 1966,
    "maxX" : 1978,
    "minY" : 1018,
    "maxY" : 1052,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1973,
        "y" : 1018
      },
      "to" : {
        "x" : 1972,
        "y" : 1032
      }
    }, {
      "from" : {
        "x" : 1972,
        "y" : 1032
      },
      "to" : {
        "x" : 1972,
        "y" : 1052
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1966,
        "y" : 1026
      },
      "b" : {
        "x" : 1978,
        "y" : 1038
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1972,
        "y" : 1032
      }
    },
    "inputs" : [ {
      "id" : 1144
    } ]
  }, {
    "id" : 661,
    "reactomeId" : 870538,
    "displayName" : "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 808,
      "y" : 642
    },
    "minX" : 768,
    "maxX" : 813,
    "minY" : 637,
    "maxY" : 653,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 810,
        "y" : 642
      },
      "to" : {
        "x" : 808,
        "y" : 642
      }
    }, {
      "from" : {
        "x" : 808,
        "y" : 642
      },
      "to" : {
        "x" : 768,
        "y" : 653
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 774,
        "y" : 647
      },
      "b" : {
        "x" : 768,
        "y" : 653
      },
      "c" : {
        "x" : 776,
        "y" : 655
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 776,
        "y" : 655
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 808,
        "y" : 642
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 808,
        "y" : 642
      }
    },
    "inputs" : [ {
      "id" : 662,
      "points" : [ {
        "x" : 809,
        "y" : 558
      } ]
    }, {
      "id" : 1445,
      "points" : [ {
        "x" : 829,
        "y" : 645
      } ]
    } ],
    "outputs" : [ {
      "id" : 663
    } ]
  }, {
    "id" : 1173,
    "reactomeId" : 173545,
    "displayName" : "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 771,
      "y" : 756
    },
    "minX" : 765,
    "maxX" : 868,
    "minY" : 677,
    "maxY" : 802,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 868,
        "y" : 677
      },
      "to" : {
        "x" : 771,
        "y" : 756
      }
    }, {
      "from" : {
        "x" : 771,
        "y" : 756
      },
      "to" : {
        "x" : 771,
        "y" : 802
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 765,
        "y" : 750
      },
      "b" : {
        "x" : 777,
        "y" : 762
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 771,
        "y" : 756
      }
    },
    "inputs" : [ {
      "id" : 1445
    } ],
    "catalysts" : [ {
      "id" : 1174,
      "points" : [ {
        "x" : 696,
        "y" : 757
      } ]
    } ]
  }, {
    "id" : 1302,
    "reactomeId" : 5252001,
    "displayName" : "ATP1B4 binds SNW1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2039,
      "y" : 704
    },
    "minX" : 2009,
    "maxX" : 2044,
    "minY" : 699,
    "maxY" : 747,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2038,
        "y" : 706
      },
      "to" : {
        "x" : 2039,
        "y" : 704
      }
    }, {
      "from" : {
        "x" : 2039,
        "y" : 704
      },
      "to" : {
        "x" : 2009,
        "y" : 747
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2010,
        "y" : 739
      },
      "b" : {
        "x" : 2009,
        "y" : 747
      },
      "c" : {
        "x" : 2016,
        "y" : 744
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2016,
        "y" : 744
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2039,
        "y" : 704
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2039,
        "y" : 704
      }
    },
    "inputs" : [ {
      "id" : 1303,
      "points" : [ {
        "x" : 2014,
        "y" : 680
      } ]
    }, {
      "id" : 1304,
      "points" : [ {
        "x" : 2069,
        "y" : 680
      } ]
    } ],
    "outputs" : [ {
      "id" : 1305
    } ]
  }, {
    "id" : 1687,
    "reactomeId" : 2106579,
    "displayName" : "WWTR1:SMAD translocates to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1506,
      "y" : 433
    },
    "minX" : 1500,
    "maxX" : 1512,
    "minY" : 397,
    "maxY" : 796,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1507,
        "y" : 397
      },
      "to" : {
        "x" : 1506,
        "y" : 433
      }
    }, {
      "from" : {
        "x" : 1506,
        "y" : 433
      },
      "to" : {
        "x" : 1508,
        "y" : 796
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1504,
        "y" : 789
      },
      "b" : {
        "x" : 1508,
        "y" : 796
      },
      "c" : {
        "x" : 1512,
        "y" : 789
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1512,
        "y" : 789
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1500,
        "y" : 427
      },
      "b" : {
        "x" : 1512,
        "y" : 439
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1506,
        "y" : 433
      }
    },
    "inputs" : [ {
      "id" : 557
    } ],
    "outputs" : [ {
      "id" : 570
    } ]
  }, {
    "id" : 1434,
    "reactomeId" : 170847,
    "displayName" : "Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 811,
      "y" : 304
    },
    "minX" : 806,
    "maxX" : 827,
    "minY" : 259,
    "maxY" : 335,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 811,
        "y" : 259
      },
      "to" : {
        "x" : 811,
        "y" : 304
      }
    }, {
      "from" : {
        "x" : 811,
        "y" : 304
      },
      "to" : {
        "x" : 827,
        "y" : 335
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 820,
        "y" : 331
      },
      "b" : {
        "x" : 827,
        "y" : 335
      },
      "c" : {
        "x" : 827,
        "y" : 327
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 827,
        "y" : 327
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 805,
        "y" : 298
      },
      "b" : {
        "x" : 817,
        "y" : 310
      },
      "s" : "",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 811,
        "y" : 304
      }
    },
    "inputs" : [ {
      "id" : 895,
      "points" : [ {
        "x" : 803,
        "y" : 204
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 893,
      "points" : [ {
        "x" : 764,
        "y" : 279
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 1435
    } ]
  }, {
    "id" : 1436,
    "reactomeId" : 173488,
    "displayName" : "The SMAD2/3:SMAD4 complex transfers to the nucleus",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 857,
      "y" : 429
    },
    "minX" : 840,
    "maxX" : 885,
    "minY" : 383,
    "maxY" : 631,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 840,
        "y" : 383
      },
      "to" : {
        "x" : 857,
        "y" : 429
      }
    }, {
      "from" : {
        "x" : 857,
        "y" : 429
      },
      "to" : {
        "x" : 885,
        "y" : 631
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 880,
        "y" : 625
      },
      "b" : {
        "x" : 885,
        "y" : 631
      },
      "c" : {
        "x" : 888,
        "y" : 624
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 888,
        "y" : 624
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 851,
        "y" : 423
      },
      "b" : {
        "x" : 863,
        "y" : 435
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 857,
        "y" : 429
      }
    },
    "inputs" : [ {
      "id" : 1435
    } ],
    "outputs" : [ {
      "id" : 1445
    } ],
    "inhibitors" : [ {
      "id" : 1313,
      "points" : [ {
        "x" : 1035,
        "y" : 397
      } ]
    } ]
  }, {
    "id" : 1309,
    "reactomeId" : 9731111,
    "displayName" : "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1257,
      "y" : 361
    },
    "minX" : 1222,
    "maxX" : 1285,
    "minY" : 355,
    "maxY" : 367,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1285,
        "y" : 356
      },
      "to" : {
        "x" : 1257,
        "y" : 361
      }
    }, {
      "from" : {
        "x" : 1257,
        "y" : 361
      },
      "to" : {
        "x" : 1222,
        "y" : 362
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1251,
        "y" : 355
      },
      "b" : {
        "x" : 1263,
        "y" : 367
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1257,
        "y" : 361
      }
    },
    "inputs" : [ {
      "id" : 1310,
      "points" : [ {
        "x" : 1290,
        "y" : 297
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 1283,
      "points" : [ {
        "x" : 1316,
        "y" : 357
      } ]
    } ],
    "outputs" : [ {
      "id" : 1311,
      "points" : [ {
        "x" : 1221,
        "y" : 302
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 1312,
      "points" : [ {
        "x" : 1134,
        "y" : 329
      } ]
    } ],
    "catalysts" : [ {
      "id" : 1313,
      "points" : [ {
        "x" : 1173,
        "y" : 390
      }, {
        "x" : 1238,
        "y" : 404
      } ]
    } ]
  }, {
    "id" : 1437,
    "reactomeId" : 2031355,
    "displayName" : "WWTR1 binds SMAD2/3:SMAD4 heterotrimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1401,
      "y" : 238
    },
    "minX" : 966,
    "maxX" : 1499,
    "minY" : 233,
    "maxY" : 369,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 966,
        "y" : 250
      },
      "to" : {
        "x" : 1401,
        "y" : 238
      }
    }, {
      "from" : {
        "x" : 1401,
        "y" : 238
      },
      "to" : {
        "x" : 1499,
        "y" : 369
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1492,
        "y" : 366
      },
      "b" : {
        "x" : 1499,
        "y" : 369
      },
      "c" : {
        "x" : 1498,
        "y" : 361
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1498,
        "y" : 361
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1401,
        "y" : 238
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1401,
        "y" : 238
      }
    },
    "inputs" : [ {
      "id" : 556,
      "points" : [ {
        "x" : 939,
        "y" : 204
      } ]
    }, {
      "id" : 1435,
      "points" : [ {
        "x" : 856,
        "y" : 335
      } ]
    } ],
    "outputs" : [ {
      "id" : 557
    } ]
  }, {
    "id" : 1822,
    "reactomeId" : 9736970,
    "displayName" : "WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1701,
      "y" : 740
    },
    "minX" : 1668,
    "maxX" : 1747,
    "minY" : 682,
    "maxY" : 773,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1668,
        "y" : 773
      },
      "to" : {
        "x" : 1701,
        "y" : 740
      }
    }, {
      "from" : {
        "x" : 1701,
        "y" : 740
      },
      "to" : {
        "x" : 1747,
        "y" : 682
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1746,
        "y" : 690
      },
      "b" : {
        "x" : 1747,
        "y" : 682
      },
      "c" : {
        "x" : 1740,
        "y" : 685
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1740,
        "y" : 685
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1701,
        "y" : 740
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1701,
        "y" : 740
      }
    },
    "inputs" : [ {
      "id" : 570,
      "points" : [ {
        "x" : 1556,
        "y" : 796
      } ]
    }, {
      "id" : 583,
      "points" : [ {
        "x" : 1639,
        "y" : 833
      } ]
    } ],
    "outputs" : [ {
      "id" : 1823
    } ]
  }, {
    "id" : 1829,
    "reactomeId" : 2106591,
    "displayName" : "WWTR1:SMAD stimulates transcription of SMAD7",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1747,
      "y" : 822
    },
    "minX" : 1639,
    "maxX" : 1808,
    "minY" : 816,
    "maxY" : 833,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1639,
        "y" : 833
      },
      "to" : {
        "x" : 1747,
        "y" : 822
      }
    }, {
      "from" : {
        "x" : 1747,
        "y" : 822
      },
      "to" : {
        "x" : 1808,
        "y" : 824
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1801,
        "y" : 828
      },
      "b" : {
        "x" : 1808,
        "y" : 824
      },
      "c" : {
        "x" : 1801,
        "y" : 820
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1801,
        "y" : 820
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1741,
        "y" : 816
      },
      "b" : {
        "x" : 1753,
        "y" : 828
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1747,
        "y" : 822
      }
    },
    "inputs" : [ {
      "id" : 583
    } ],
    "outputs" : [ {
      "id" : 584
    } ],
    "activators" : [ {
      "id" : 1305,
      "points" : [ {
        "x" : 1956,
        "y" : 775
      } ]
    }, {
      "id" : 1823,
      "points" : [ {
        "x" : 1763,
        "y" : 682
      } ]
    } ]
  }, {
    "id" : 1320,
    "reactomeId" : 9730967,
    "displayName" : "STAT1 stimulates SMAD7 gene transcription",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1726,
      "y" : 840
    },
    "minX" : 1639,
    "maxX" : 1808,
    "minY" : 829,
    "maxY" : 846,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1639,
        "y" : 833
      },
      "to" : {
        "x" : 1726,
        "y" : 840
      }
    }, {
      "from" : {
        "x" : 1726,
        "y" : 840
      },
      "to" : {
        "x" : 1808,
        "y" : 829
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1802,
        "y" : 834
      },
      "b" : {
        "x" : 1808,
        "y" : 829
      },
      "c" : {
        "x" : 1801,
        "y" : 826
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1801,
        "y" : 826
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1720,
        "y" : 834
      },
      "b" : {
        "x" : 1732,
        "y" : 846
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1726,
        "y" : 840
      }
    },
    "inputs" : [ {
      "id" : 583
    } ],
    "outputs" : [ {
      "id" : 584
    } ],
    "activators" : [ {
      "id" : 1321,
      "points" : [ {
        "x" : 1653,
        "y" : 730
      } ]
    } ]
  }, {
    "id" : 681,
    "reactomeId" : 2176475,
    "displayName" : "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 975,
      "y" : 656
    },
    "minX" : 958,
    "maxX" : 992,
    "minY" : 650,
    "maxY" : 662,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 958,
        "y" : 655
      },
      "to" : {
        "x" : 975,
        "y" : 656
      }
    }, {
      "from" : {
        "x" : 975,
        "y" : 656
      },
      "to" : {
        "x" : 992,
        "y" : 656
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 969,
        "y" : 650
      },
      "b" : {
        "x" : 981,
        "y" : 662
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 975,
        "y" : 656
      }
    },
    "inputs" : [ {
      "id" : 682,
      "points" : [ {
        "x" : 954,
        "y" : 681
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 1445,
      "points" : [ {
        "x" : 948,
        "y" : 654
      } ]
    } ],
    "outputs" : [ {
      "id" : 687,
      "points" : [ {
        "x" : 1011,
        "y" : 685
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 1579,
      "points" : [ {
        "x" : 1014,
        "y" : 655
      } ]
    } ],
    "catalysts" : [ {
      "id" : 690,
      "points" : [ {
        "x" : 975,
        "y" : 629
      } ]
    } ]
  }, {
    "id" : 1196,
    "reactomeId" : 2187309,
    "displayName" : "SMAD2/3:SMAD4 heterotrimer binds SP1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 755,
      "y" : 952
    },
    "minX" : 750,
    "maxX" : 774,
    "minY" : 886,
    "maxY" : 980,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 774,
        "y" : 980
      },
      "to" : {
        "x" : 755,
        "y" : 952
      }
    }, {
      "from" : {
        "x" : 755,
        "y" : 952
      },
      "to" : {
        "x" : 750,
        "y" : 886
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 755,
        "y" : 893
      },
      "b" : {
        "x" : 750,
        "y" : 886
      },
      "c" : {
        "x" : 747,
        "y" : 893
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 747,
        "y" : 893
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 755,
        "y" : 952
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 755,
        "y" : 952
      }
    },
    "inputs" : [ {
      "id" : 1197,
      "points" : [ {
        "x" : 672,
        "y" : 1044
      } ]
    }, {
      "id" : 1445,
      "points" : [ {
        "x" : 882,
        "y" : 677
      } ]
    } ],
    "outputs" : [ {
      "id" : 1198
    } ]
  }, {
    "id" : 1709,
    "reactomeId" : 9736959,
    "displayName" : "WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1611,
      "y" : 923
    },
    "minX" : 1513,
    "maxX" : 1661,
    "minY" : 875,
    "maxY" : 1050,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1513,
        "y" : 875
      },
      "to" : {
        "x" : 1611,
        "y" : 923
      }
    }, {
      "from" : {
        "x" : 1611,
        "y" : 923
      },
      "to" : {
        "x" : 1661,
        "y" : 1050
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1655,
        "y" : 1045
      },
      "b" : {
        "x" : 1661,
        "y" : 1050
      },
      "c" : {
        "x" : 1662,
        "y" : 1042
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1662,
        "y" : 1042
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1611,
        "y" : 923
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1611,
        "y" : 923
      }
    },
    "inputs" : [ {
      "id" : 570,
      "points" : [ {
        "x" : 1509,
        "y" : 824
      } ]
    }, {
      "id" : 590,
      "points" : [ {
        "x" : 1524,
        "y" : 922
      } ]
    } ],
    "outputs" : [ {
      "id" : 1710
    } ],
    "inhibitors" : [ {
      "id" : 1756,
      "points" : [ {
        "x" : 1657,
        "y" : 910
      } ]
    } ]
  }, {
    "id" : 1970,
    "reactomeId" : 1484099,
    "displayName" : "MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1435,
      "y" : 1277
    },
    "minX" : 1288,
    "maxX" : 1503,
    "minY" : 1271,
    "maxY" : 1283,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1288,
        "y" : 1277
      },
      "to" : {
        "x" : 1435,
        "y" : 1277
      }
    }, {
      "from" : {
        "x" : 1435,
        "y" : 1277
      },
      "to" : {
        "x" : 1503,
        "y" : 1279
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1496,
        "y" : 1283
      },
      "b" : {
        "x" : 1503,
        "y" : 1279
      },
      "c" : {
        "x" : 1496,
        "y" : 1275
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1496,
        "y" : 1275
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1429,
        "y" : 1271
      },
      "b" : {
        "x" : 1441,
        "y" : 1283
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1435,
        "y" : 1277
      }
    },
    "inputs" : [ {
      "id" : 629
    } ],
    "outputs" : [ {
      "id" : 630
    } ],
    "inhibitors" : [ {
      "id" : 1971,
      "points" : [ {
        "x" : 1435,
        "y" : 1215
      } ]
    } ]
  }, {
    "id" : 1972,
    "reactomeId" : 9736984,
    "displayName" : "p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1320,
      "y" : 1227
    },
    "minX" : 1280,
    "maxX" : 1364,
    "minY" : 1215,
    "maxY" : 1232,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1280,
        "y" : 1228
      },
      "to" : {
        "x" : 1320,
        "y" : 1227
      }
    }, {
      "from" : {
        "x" : 1320,
        "y" : 1227
      },
      "to" : {
        "x" : 1364,
        "y" : 1215
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1358,
        "y" : 1221
      },
      "b" : {
        "x" : 1364,
        "y" : 1215
      },
      "c" : {
        "x" : 1356,
        "y" : 1213
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1356,
        "y" : 1213
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1320,
        "y" : 1227
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1320,
        "y" : 1227
      }
    },
    "inputs" : [ {
      "id" : 599,
      "points" : [ {
        "x" : 1238,
        "y" : 1220
      } ]
    }, {
      "id" : 629,
      "points" : [ {
        "x" : 1288,
        "y" : 1277
      } ]
    } ],
    "outputs" : [ {
      "id" : 1971
    } ]
  }, {
    "id" : 1716,
    "reactomeId" : 2106586,
    "displayName" : "WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1560,
      "y" : 1072
    },
    "minX" : 1524,
    "maxX" : 1636,
    "minY" : 922,
    "maxY" : 1724,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1524,
        "y" : 922
      },
      "to" : {
        "x" : 1560,
        "y" : 1072
      }
    }, {
      "from" : {
        "x" : 1560,
        "y" : 1072
      },
      "to" : {
        "x" : 1636,
        "y" : 1724
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1631,
        "y" : 1718
      },
      "b" : {
        "x" : 1636,
        "y" : 1724
      },
      "c" : {
        "x" : 1639,
        "y" : 1717
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1639,
        "y" : 1717
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1554,
        "y" : 1066
      },
      "b" : {
        "x" : 1566,
        "y" : 1078
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1560,
        "y" : 1072
      }
    },
    "inputs" : [ {
      "id" : 590
    } ],
    "outputs" : [ {
      "id" : 2040
    } ],
    "inhibitors" : [ {
      "id" : 864,
      "points" : [ {
        "x" : 1217,
        "y" : 904
      } ]
    } ],
    "activators" : [ {
      "id" : 1710,
      "points" : [ {
        "x" : 1613,
        "y" : 1075
      } ]
    } ]
  }, {
    "id" : 951,
    "reactomeId" : 173481,
    "displayName" : "SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 961,
      "y" : 926
    },
    "minX" : 946,
    "maxX" : 1009,
    "minY" : 888,
    "maxY" : 956,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 946,
        "y" : 888
      },
      "to" : {
        "x" : 961,
        "y" : 926
      }
    }, {
      "from" : {
        "x" : 961,
        "y" : 926
      },
      "to" : {
        "x" : 1009,
        "y" : 956
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1001,
        "y" : 956
      },
      "b" : {
        "x" : 1009,
        "y" : 956
      },
      "c" : {
        "x" : 1005,
        "y" : 949
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1005,
        "y" : 949
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 961,
        "y" : 926
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 961,
        "y" : 926
      }
    },
    "inputs" : [ {
      "id" : 952,
      "points" : [ {
        "x" : 971,
        "y" : 850
      } ]
    }, {
      "id" : 953,
      "points" : [ {
        "x" : 995,
        "y" : 887
      } ]
    }, {
      "id" : 1445,
      "points" : [ {
        "x" : 892,
        "y" : 677
      } ]
    } ],
    "outputs" : [ {
      "id" : 954
    } ]
  }, {
    "id" : 1214,
    "reactomeId" : 2187330,
    "displayName" : "PARP1 binds SMAD2/3:SMAD4 heterotrimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 936,
      "y" : 571
    },
    "minX" : 913,
    "maxX" : 973,
    "minY" : 565,
    "maxY" : 584,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 913,
        "y" : 584
      },
      "to" : {
        "x" : 936,
        "y" : 571
      }
    }, {
      "from" : {
        "x" : 936,
        "y" : 571
      },
      "to" : {
        "x" : 973,
        "y" : 565
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 967,
        "y" : 570
      },
      "b" : {
        "x" : 973,
        "y" : 565
      },
      "c" : {
        "x" : 966,
        "y" : 562
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 966,
        "y" : 562
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 936,
        "y" : 571
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 936,
        "y" : 571
      }
    },
    "inputs" : [ {
      "id" : 1215,
      "points" : [ {
        "x" : 928,
        "y" : 548
      } ]
    }, {
      "id" : 1445,
      "points" : [ {
        "x" : 894,
        "y" : 631
      } ]
    } ],
    "outputs" : [ {
      "id" : 1216
    } ]
  }, {
    "id" : 838,
    "reactomeId" : 2179276,
    "displayName" : "SMURF2 monoubiquitinates SMAD3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1341,
      "y" : 754
    },
    "minX" : 1296,
    "maxX" : 1350,
    "minY" : 748,
    "maxY" : 802,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1296,
        "y" : 754
      },
      "to" : {
        "x" : 1341,
        "y" : 754
      }
    }, {
      "from" : {
        "x" : 1341,
        "y" : 754
      },
      "to" : {
        "x" : 1345,
        "y" : 773
      }
    }, {
      "from" : {
        "x" : 1345,
        "y" : 773
      },
      "to" : {
        "x" : 1350,
        "y" : 802
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1335,
        "y" : 748
      },
      "b" : {
        "x" : 1347,
        "y" : 760
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1341,
        "y" : 754
      }
    },
    "inputs" : [ {
      "id" : 761,
      "points" : [ {
        "x" : 1272,
        "y" : 751
      } ]
    }, {
      "id" : 745,
      "points" : [ {
        "x" : 1303,
        "y" : 717
      } ],
      "stoichiometry" : 6
    } ],
    "outputs" : [ {
      "id" : 760,
      "points" : [ {
        "x" : 1089,
        "y" : 731
      }, {
        "x" : 1160,
        "y" : 790
      } ]
    }, {
      "id" : 840,
      "points" : [ {
        "x" : 1455,
        "y" : 757
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 2078,
      "points" : [ {
        "x" : 1364,
        "y" : 847
      } ],
      "stoichiometry" : 3
    } ],
    "catalysts" : [ {
      "id" : 761,
      "points" : [ {
        "x" : 1247,
        "y" : 765
      }, {
        "x" : 1294,
        "y" : 783
      } ]
    } ]
  }, {
    "id" : 711,
    "reactomeId" : 2176491,
    "displayName" : "NEDD4L binds phosphorylated linker region of SMAD2/3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1155,
      "y" : 647
    },
    "minX" : 1150,
    "maxX" : 1187,
    "minY" : 642,
    "maxY" : 652,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1154,
        "y" : 647
      },
      "to" : {
        "x" : 1155,
        "y" : 647
      }
    }, {
      "from" : {
        "x" : 1155,
        "y" : 647
      },
      "to" : {
        "x" : 1187,
        "y" : 646
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1180,
        "y" : 650
      },
      "b" : {
        "x" : 1187,
        "y" : 646
      },
      "c" : {
        "x" : 1180,
        "y" : 642
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1180,
        "y" : 642
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1155,
        "y" : 647
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1155,
        "y" : 647
      }
    },
    "inputs" : [ {
      "id" : 712,
      "points" : [ {
        "x" : 1156,
        "y" : 624
      } ]
    }, {
      "id" : 1579,
      "points" : [ {
        "x" : 1141,
        "y" : 648
      } ]
    } ],
    "outputs" : [ {
      "id" : 713
    } ]
  }, {
    "id" : 1361,
    "reactomeId" : 9733207,
    "displayName" : "p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 755,
      "y" : 1188
    },
    "minX" : 740,
    "maxX" : 760,
    "minY" : 1163,
    "maxY" : 1217,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 745,
        "y" : 1163
      },
      "to" : {
        "x" : 755,
        "y" : 1188
      }
    }, {
      "from" : {
        "x" : 755,
        "y" : 1188
      },
      "to" : {
        "x" : 740,
        "y" : 1217
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 740,
        "y" : 1209
      },
      "b" : {
        "x" : 740,
        "y" : 1217
      },
      "c" : {
        "x" : 747,
        "y" : 1213
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 747,
        "y" : 1213
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 755,
        "y" : 1188
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 755,
        "y" : 1188
      }
    },
    "inputs" : [ {
      "id" : 1197,
      "points" : [ {
        "x" : 663,
        "y" : 1068
      } ]
    }, {
      "id" : 1362,
      "points" : [ {
        "x" : 561,
        "y" : 1155
      } ]
    }, {
      "id" : 1363,
      "points" : [ {
        "x" : 758,
        "y" : 1092
      } ]
    }, {
      "id" : 1364,
      "points" : [ {
        "x" : 575,
        "y" : 1111
      } ]
    } ],
    "outputs" : [ {
      "id" : 1365
    } ]
  }, {
    "id" : 597,
    "reactomeId" : 2127257,
    "displayName" : "SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1044,
      "y" : 1196
    },
    "minX" : 949,
    "maxX" : 1095,
    "minY" : 1191,
    "maxY" : 1201,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 949,
        "y" : 1196
      },
      "to" : {
        "x" : 1044,
        "y" : 1196
      }
    }, {
      "from" : {
        "x" : 1044,
        "y" : 1196
      },
      "to" : {
        "x" : 1095,
        "y" : 1197
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1088,
        "y" : 1201
      },
      "b" : {
        "x" : 1095,
        "y" : 1197
      },
      "c" : {
        "x" : 1088,
        "y" : 1193
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1088,
        "y" : 1193
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1044,
        "y" : 1196
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1044,
        "y" : 1196
      }
    },
    "inputs" : [ {
      "id" : 598,
      "points" : [ {
        "x" : 952,
        "y" : 1242
      } ]
    }, {
      "id" : 1445,
      "points" : [ {
        "x" : 889,
        "y" : 677
      } ]
    } ],
    "outputs" : [ {
      "id" : 599
    } ]
  }, {
    "id" : 1239,
    "reactomeId" : 2187325,
    "displayName" : "PARP1 ADP-ribosylates SMAD3 and SMAD4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1150,
      "y" : 549
    },
    "minX" : 1119,
    "maxX" : 1175,
    "minY" : 543,
    "maxY" : 555,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1119,
        "y" : 548
      },
      "to" : {
        "x" : 1150,
        "y" : 549
      }
    }, {
      "from" : {
        "x" : 1150,
        "y" : 549
      },
      "to" : {
        "x" : 1175,
        "y" : 548
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1144,
        "y" : 543
      },
      "b" : {
        "x" : 1156,
        "y" : 555
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1150,
        "y" : 549
      }
    },
    "inputs" : [ {
      "id" : 1216,
      "points" : [ {
        "x" : 1082,
        "y" : 552
      } ]
    }, {
      "id" : 1240,
      "points" : [ {
        "x" : 1119,
        "y" : 564
      } ]
    } ],
    "outputs" : [ {
      "id" : 1215,
      "points" : [ {
        "x" : 963,
        "y" : 529
      }, {
        "x" : 1110,
        "y" : 506
      } ]
    }, {
      "id" : 1242,
      "points" : [ {
        "x" : 1202,
        "y" : 570
      } ]
    }, {
      "id" : 1546,
      "points" : [ {
        "x" : 1259,
        "y" : 558
      } ]
    } ],
    "catalysts" : [ {
      "id" : 1216,
      "points" : [ {
        "x" : 1075,
        "y" : 539
      }, {
        "x" : 1123,
        "y" : 524
      } ]
    } ]
  }, {
    "id" : 1114,
    "reactomeId" : 2186767,
    "displayName" : "Degradation of ubiquitinated SKI/SKIL",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1376,
      "y" : 1093
    },
    "minX" : 1370,
    "maxX" : 1382,
    "minY" : 1079,
    "maxY" : 1111,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1376,
        "y" : 1079
      },
      "to" : {
        "x" : 1376,
        "y" : 1093
      }
    }, {
      "from" : {
        "x" : 1376,
        "y" : 1093
      },
      "to" : {
        "x" : 1376,
        "y" : 1111
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1370,
        "y" : 1087
      },
      "b" : {
        "x" : 1382,
        "y" : 1099
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1376,
        "y" : 1093
      }
    },
    "inputs" : [ {
      "id" : 1027
    } ]
  }, {
    "id" : 1755,
    "reactomeId" : 9736966,
    "displayName" : "SMAD7 binds SERPINE1 gene promoter",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1673,
      "y" : 968
    },
    "minX" : 1668,
    "maxX" : 1700,
    "minY" : 919,
    "maxY" : 1013,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1681,
        "y" : 1013
      },
      "to" : {
        "x" : 1673,
        "y" : 968
      }
    }, {
      "from" : {
        "x" : 1673,
        "y" : 968
      },
      "to" : {
        "x" : 1700,
        "y" : 919
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1700,
        "y" : 927
      },
      "b" : {
        "x" : 1700,
        "y" : 919
      },
      "c" : {
        "x" : 1693,
        "y" : 923
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1693,
        "y" : 923
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1673,
        "y" : 968
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1673,
        "y" : 968
      }
    },
    "inputs" : [ {
      "id" : 584,
      "points" : [ {
        "x" : 1833,
        "y" : 838
      } ]
    }, {
      "id" : 590,
      "points" : [ {
        "x" : 1524,
        "y" : 922
      } ]
    } ],
    "outputs" : [ {
      "id" : 1756
    } ]
  }, {
    "id" : 861,
    "reactomeId" : 2186607,
    "displayName" : "TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1025,
      "y" : 793
    },
    "minX" : 1001,
    "maxX" : 1149,
    "minY" : 775,
    "maxY" : 862,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1001,
        "y" : 775
      },
      "to" : {
        "x" : 1025,
        "y" : 793
      }
    }, {
      "from" : {
        "x" : 1025,
        "y" : 793
      },
      "to" : {
        "x" : 1149,
        "y" : 862
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1141,
        "y" : 862
      },
      "b" : {
        "x" : 1149,
        "y" : 862
      },
      "c" : {
        "x" : 1145,
        "y" : 855
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1145,
        "y" : 855
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1025,
        "y" : 793
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1025,
        "y" : 793
      }
    },
    "inputs" : [ {
      "id" : 918,
      "points" : [ {
        "x" : 1053,
        "y" : 768
      } ]
    }, {
      "id" : 862,
      "points" : [ {
        "x" : 1103,
        "y" : 807
      } ]
    }, {
      "id" : 1445,
      "points" : [ {
        "x" : 903,
        "y" : 677
      } ]
    } ],
    "outputs" : [ {
      "id" : 864
    } ]
  }, {
    "id" : 993,
    "reactomeId" : 2186643,
    "displayName" : "MEN1 binds SMAD2/3:SMAD4 heterotrimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 825,
      "y" : 989
    },
    "minX" : 820,
    "maxX" : 863,
    "minY" : 886,
    "maxY" : 1132,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 863,
        "y" : 886
      },
      "to" : {
        "x" : 825,
        "y" : 989
      }
    }, {
      "from" : {
        "x" : 825,
        "y" : 989
      },
      "to" : {
        "x" : 841,
        "y" : 1132
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 836,
        "y" : 1126
      },
      "b" : {
        "x" : 841,
        "y" : 1132
      },
      "c" : {
        "x" : 844,
        "y" : 1125
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 844,
        "y" : 1125
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 825,
        "y" : 989
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 825,
        "y" : 989
      }
    },
    "inputs" : [ {
      "id" : 994,
      "points" : [ {
        "x" : 869,
        "y" : 961
      } ]
    }, {
      "id" : 1445,
      "points" : [ {
        "x" : 886,
        "y" : 677
      } ]
    } ],
    "outputs" : [ {
      "id" : 995
    } ]
  }, {
    "id" : 2018,
    "reactomeId" : 9736992,
    "displayName" : "p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 952,
      "y" : 1428
    },
    "minX" : 916,
    "maxX" : 1013,
    "minY" : 1421,
    "maxY" : 1433,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 916,
        "y" : 1421
      },
      "to" : {
        "x" : 952,
        "y" : 1428
      }
    }, {
      "from" : {
        "x" : 952,
        "y" : 1428
      },
      "to" : {
        "x" : 1013,
        "y" : 1431
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1006,
        "y" : 1435
      },
      "b" : {
        "x" : 1013,
        "y" : 1431
      },
      "c" : {
        "x" : 1006,
        "y" : 1427
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1006,
        "y" : 1427
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 952,
        "y" : 1428
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 952,
        "y" : 1428
      }
    },
    "inputs" : [ {
      "id" : 1445,
      "points" : [ {
        "x" : 888,
        "y" : 677
      } ]
    }, {
      "id" : 1176,
      "points" : [ {
        "x" : 902,
        "y" : 1503
      } ]
    } ],
    "outputs" : [ {
      "id" : 2019
    } ]
  }, {
    "id" : 2020,
    "reactomeId" : 2187293,
    "displayName" : "SMAD2/3:SMAD4 complex positively regulates JUNB transcription",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1074,
      "y" : 1514
    },
    "minX" : 902,
    "maxX" : 1188,
    "minY" : 1496,
    "maxY" : 1520,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 902,
        "y" : 1503
      },
      "to" : {
        "x" : 1074,
        "y" : 1514
      }
    }, {
      "from" : {
        "x" : 1074,
        "y" : 1514
      },
      "to" : {
        "x" : 1188,
        "y" : 1496
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1182,
        "y" : 1501
      },
      "b" : {
        "x" : 1188,
        "y" : 1496
      },
      "c" : {
        "x" : 1181,
        "y" : 1493
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1181,
        "y" : 1493
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1068,
        "y" : 1508
      },
      "b" : {
        "x" : 1080,
        "y" : 1520
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1074,
        "y" : 1514
      }
    },
    "inputs" : [ {
      "id" : 1176
    } ],
    "outputs" : [ {
      "id" : 1179
    } ],
    "activators" : [ {
      "id" : 2019,
      "points" : [ {
        "x" : 1073,
        "y" : 1456
      } ]
    } ]
  }, {
    "id" : 869,
    "reactomeId" : 870449,
    "displayName" : "TRIM33 monoubiquitinates SMAD4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 725,
      "y" : 590
    },
    "minX" : 698,
    "maxX" : 731,
    "minY" : 548,
    "maxY" : 601,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 709,
        "y" : 601
      },
      "to" : {
        "x" : 725,
        "y" : 590
      }
    }, {
      "from" : {
        "x" : 725,
        "y" : 590
      },
      "to" : {
        "x" : 698,
        "y" : 548
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 719,
        "y" : 584
      },
      "b" : {
        "x" : 731,
        "y" : 596
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 725,
        "y" : 590
      }
    },
    "inputs" : [ {
      "id" : 663,
      "points" : [ {
        "x" : 711,
        "y" : 647
      } ]
    }, {
      "id" : 873,
      "points" : [ {
        "x" : 659,
        "y" : 601
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 662,
      "points" : [ {
        "x" : 778,
        "y" : 545
      } ]
    }, {
      "id" : 871,
      "points" : [ {
        "x" : 721,
        "y" : 508
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 2219,
      "points" : [ {
        "x" : 626,
        "y" : 537
      } ],
      "stoichiometry" : 3
    } ],
    "catalysts" : [ {
      "id" : 663,
      "points" : [ {
        "x" : 739,
        "y" : 647
      }, {
        "x" : 755,
        "y" : 640
      } ]
    } ]
  }, {
    "id" : 1639,
    "reactomeId" : 9736953,
    "displayName" : "FURIN translocates to the plasma membrane",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 278,
      "y" : 256
    },
    "minX" : 224,
    "maxX" : 314,
    "minY" : 62,
    "maxY" : 598,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 314,
        "y" : 598
      },
      "to" : {
        "x" : 278,
        "y" : 256
      }
    }, {
      "from" : {
        "x" : 278,
        "y" : 256
      },
      "to" : {
        "x" : 224,
        "y" : 62
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 230,
        "y" : 68
      },
      "b" : {
        "x" : 224,
        "y" : 62
      },
      "c" : {
        "x" : 222,
        "y" : 70
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 222,
        "y" : 70
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 272,
        "y" : 250
      },
      "b" : {
        "x" : 284,
        "y" : 262
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 278,
        "y" : 256
      }
    },
    "inputs" : [ {
      "id" : 1332
    } ],
    "outputs" : [ {
      "id" : 1640
    } ]
  }, {
    "id" : 744,
    "reactomeId" : 2176502,
    "displayName" : "NEDD4L ubiquitinates SMAD2/3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1344,
      "y" : 642
    },
    "minX" : 1326,
    "maxX" : 1358,
    "minY" : 636,
    "maxY" : 648,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1326,
        "y" : 643
      },
      "to" : {
        "x" : 1344,
        "y" : 642
      }
    }, {
      "from" : {
        "x" : 1344,
        "y" : 642
      },
      "to" : {
        "x" : 1358,
        "y" : 642
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1344,
        "y" : 642
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1344,
        "y" : 642
      }
    },
    "inputs" : [ {
      "id" : 745,
      "points" : [ {
        "x" : 1308,
        "y" : 684
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 713,
      "points" : [ {
        "x" : 1311,
        "y" : 643
      } ]
    } ],
    "outputs" : [ {
      "id" : 712,
      "points" : [ {
        "x" : 1189,
        "y" : 609
      }, {
        "x" : 1349,
        "y" : 606
      } ]
    }, {
      "id" : 746,
      "points" : [ {
        "x" : 1382,
        "y" : 644
      } ]
    } ]
  }, {
    "id" : 874,
    "reactomeId" : 870477,
    "displayName" : "Ubiquitinated SMAD4 translocates from the nucleus to the cytosol",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 556,
      "y" : 472
    },
    "minX" : 548,
    "maxX" : 569,
    "minY" : 399,
    "maxY" : 518,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 569,
        "y" : 518
      },
      "to" : {
        "x" : 556,
        "y" : 472
      }
    }, {
      "from" : {
        "x" : 556,
        "y" : 472
      },
      "to" : {
        "x" : 548,
        "y" : 399
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 553,
        "y" : 405
      },
      "b" : {
        "x" : 548,
        "y" : 399
      },
      "c" : {
        "x" : 545,
        "y" : 406
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 545,
        "y" : 406
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 550,
        "y" : 466
      },
      "b" : {
        "x" : 562,
        "y" : 478
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 556,
        "y" : 472
      }
    },
    "inputs" : [ {
      "id" : 2219
    } ],
    "outputs" : [ {
      "id" : 2220
    } ]
  }, {
    "id" : 1132,
    "reactomeId" : 2186771,
    "displayName" : "RNF111 binds SMAD7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1890,
      "y" : 897
    },
    "minX" : 1835,
    "maxX" : 1940,
    "minY" : 889,
    "maxY" : 900,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1840,
        "y" : 894
      },
      "to" : {
        "x" : 1890,
        "y" : 897
      }
    }, {
      "from" : {
        "x" : 1890,
        "y" : 897
      },
      "to" : {
        "x" : 1940,
        "y" : 900
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1933,
        "y" : 904
      },
      "b" : {
        "x" : 1940,
        "y" : 900
      },
      "c" : {
        "x" : 1933,
        "y" : 896
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1933,
        "y" : 896
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1890,
        "y" : 897
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1890,
        "y" : 897
      }
    },
    "inputs" : [ {
      "id" : 1133,
      "points" : [ {
        "x" : 1817,
        "y" : 971
      } ]
    }, {
      "id" : 584,
      "points" : [ {
        "x" : 1840,
        "y" : 838
      } ]
    } ],
    "outputs" : [ {
      "id" : 1134
    } ]
  }, {
    "id" : 880,
    "reactomeId" : 870479,
    "displayName" : "USP9X (FAM) binds to ubiquitinated SMAD4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 565,
      "y" : 321
    },
    "minX" : 560,
    "maxX" : 574,
    "minY" : 285,
    "maxY" : 348,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 574,
        "y" : 348
      },
      "to" : {
        "x" : 565,
        "y" : 321
      }
    }, {
      "from" : {
        "x" : 565,
        "y" : 321
      },
      "to" : {
        "x" : 564,
        "y" : 285
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 568,
        "y" : 292
      },
      "b" : {
        "x" : 564,
        "y" : 285
      },
      "c" : {
        "x" : 560,
        "y" : 292
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 560,
        "y" : 292
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 565,
        "y" : 321
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 565,
        "y" : 321
      }
    },
    "inputs" : [ {
      "id" : 2220,
      "points" : [ {
        "x" : 555,
        "y" : 370
      } ]
    }, {
      "id" : 881,
      "points" : [ {
        "x" : 607,
        "y" : 346
      } ]
    } ],
    "outputs" : [ {
      "id" : 882
    } ]
  }, {
    "id" : 1394,
    "reactomeId" : 9733216,
    "displayName" : "COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 557,
      "y" : 1307
    },
    "minX" : 353,
    "maxX" : 563,
    "minY" : 1155,
    "maxY" : 1313,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 561,
        "y" : 1155
      },
      "to" : {
        "x" : 557,
        "y" : 1307
      }
    }, {
      "from" : {
        "x" : 557,
        "y" : 1307
      },
      "to" : {
        "x" : 353,
        "y" : 1272
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 361,
        "y" : 1269
      },
      "b" : {
        "x" : 353,
        "y" : 1272
      },
      "c" : {
        "x" : 359,
        "y" : 1277
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 359,
        "y" : 1277
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 551,
        "y" : 1301
      },
      "b" : {
        "x" : 563,
        "y" : 1313
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 557,
        "y" : 1307
      }
    },
    "inputs" : [ {
      "id" : 1362
    } ],
    "outputs" : [ {
      "id" : 1395
    } ],
    "inhibitors" : [ {
      "id" : 1406,
      "points" : [ {
        "x" : 608,
        "y" : 1415
      } ]
    } ],
    "activators" : [ {
      "id" : 1365,
      "points" : [ {
        "x" : 662,
        "y" : 1269
      } ]
    } ]
  }, {
    "id" : 755,
    "reactomeId" : 2176503,
    "displayName" : "Degradation of SMAD2/3:SMAD4 complex",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1429,
      "y" : 693
    },
    "minX" : 1423,
    "maxX" : 1435,
    "minY" : 677,
    "maxY" : 713,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1429,
        "y" : 677
      },
      "to" : {
        "x" : 1429,
        "y" : 693
      }
    }, {
      "from" : {
        "x" : 1429,
        "y" : 693
      },
      "to" : {
        "x" : 1430,
        "y" : 713
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1423,
        "y" : 687
      },
      "b" : {
        "x" : 1435,
        "y" : 699
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1429,
        "y" : 693
      }
    },
    "inputs" : [ {
      "id" : 746
    } ]
  }, {
    "id" : 2038,
    "reactomeId" : 9733203,
    "displayName" : "FURIN gene transcription is stimulated by SMAD2/SMAD3:SMAD4",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 586,
      "y" : 657
    },
    "minX" : 341,
    "maxX" : 592,
    "minY" : 576,
    "maxY" : 663,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 571,
        "y" : 576
      },
      "to" : {
        "x" : 586,
        "y" : 657
      }
    }, {
      "from" : {
        "x" : 586,
        "y" : 657
      },
      "to" : {
        "x" : 341,
        "y" : 615
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 349,
        "y" : 612
      },
      "b" : {
        "x" : 341,
        "y" : 615
      },
      "c" : {
        "x" : 347,
        "y" : 620
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 347,
        "y" : 620
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 580,
        "y" : 651
      },
      "b" : {
        "x" : 592,
        "y" : 663
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 586,
        "y" : 657
      }
    },
    "inputs" : [ {
      "id" : 1307
    } ],
    "outputs" : [ {
      "id" : 1332
    } ],
    "activators" : [ {
      "id" : 1445,
      "points" : [ {
        "x" : 839,
        "y" : 677
      }, {
        "x" : 697,
        "y" : 721
      } ]
    } ]
  }, {
    "id" : 1143,
    "reactomeId" : 2186785,
    "displayName" : "RNF111 ubiquitinates SMAD7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1972,
      "y" : 960
    },
    "minX" : 1966,
    "maxX" : 1978,
    "minY" : 941,
    "maxY" : 977,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1972,
        "y" : 941
      },
      "to" : {
        "x" : 1972,
        "y" : 960
      }
    }, {
      "from" : {
        "x" : 1972,
        "y" : 960
      },
      "to" : {
        "x" : 1972,
        "y" : 977
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1966,
        "y" : 954
      },
      "b" : {
        "x" : 1978,
        "y" : 966
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1972,
        "y" : 960
      }
    },
    "inputs" : [ {
      "id" : 1134,
      "points" : [ {
        "x" : 1972,
        "y" : 922
      } ]
    }, {
      "id" : 1146,
      "points" : [ {
        "x" : 1987,
        "y" : 939
      } ]
    } ],
    "outputs" : [ {
      "id" : 1133,
      "points" : [ {
        "x" : 1848,
        "y" : 984
      } ]
    }, {
      "id" : 1144,
      "points" : [ {
        "x" : 1973,
        "y" : 990
      } ]
    } ],
    "catalysts" : [ {
      "id" : 1134,
      "points" : [ {
        "x" : 1961,
        "y" : 922
      }, {
        "x" : 1950,
        "y" : 937
      } ]
    } ]
  }, {
    "id" : 1015,
    "reactomeId" : 2186741,
    "displayName" : "SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1040,
      "y" : 1027
    },
    "minX" : 1035,
    "maxX" : 1069,
    "minY" : 1022,
    "maxY" : 1040,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1037,
        "y" : 1026
      },
      "to" : {
        "x" : 1040,
        "y" : 1027
      }
    }, {
      "from" : {
        "x" : 1040,
        "y" : 1027
      },
      "to" : {
        "x" : 1069,
        "y" : 1040
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1061,
        "y" : 1041
      },
      "b" : {
        "x" : 1069,
        "y" : 1040
      },
      "c" : {
        "x" : 1064,
        "y" : 1034
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1064,
        "y" : 1034
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1040,
        "y" : 1027
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1040,
        "y" : 1027
      }
    },
    "inputs" : [ {
      "id" : 1016,
      "points" : [ {
        "x" : 1020,
        "y" : 1031
      } ]
    }, {
      "id" : 954,
      "points" : [ {
        "x" : 1036,
        "y" : 998
      } ]
    } ],
    "outputs" : [ {
      "id" : 1017
    } ]
  }, {
    "id" : 1271,
    "reactomeId" : 2187388,
    "displayName" : "PPM1A protein phosphatase binds phosphorylated SMAD2/3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 886,
      "y" : 495
    },
    "minX" : 881,
    "maxX" : 909,
    "minY" : 481,
    "maxY" : 524,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 881,
        "y" : 524
      },
      "to" : {
        "x" : 886,
        "y" : 495
      }
    }, {
      "from" : {
        "x" : 886,
        "y" : 495
      },
      "to" : {
        "x" : 909,
        "y" : 481
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 905,
        "y" : 488
      },
      "b" : {
        "x" : 909,
        "y" : 481
      },
      "c" : {
        "x" : 901,
        "y" : 481
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 901,
        "y" : 481
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 886,
        "y" : 495
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 886,
        "y" : 495
      }
    },
    "inputs" : [ {
      "id" : 1272,
      "points" : [ {
        "x" : 923,
        "y" : 508
      } ]
    }, {
      "id" : 1445,
      "points" : [ {
        "x" : 887,
        "y" : 631
      } ]
    } ],
    "outputs" : [ {
      "id" : 1273
    } ]
  }, {
    "id" : 759,
    "reactomeId" : 2179274,
    "displayName" : "SMURF2 binds SMAD3 phosphorylated in the linker region",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1163,
      "y" : 710
    },
    "minX" : 1136,
    "maxX" : 1185,
    "minY" : 691,
    "maxY" : 725,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1141,
        "y" : 696
      },
      "to" : {
        "x" : 1163,
        "y" : 710
      }
    }, {
      "from" : {
        "x" : 1163,
        "y" : 710
      },
      "to" : {
        "x" : 1185,
        "y" : 725
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1177,
        "y" : 724
      },
      "b" : {
        "x" : 1185,
        "y" : 725
      },
      "c" : {
        "x" : 1182,
        "y" : 718
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1182,
        "y" : 718
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1163,
        "y" : 710
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1163,
        "y" : 710
      }
    },
    "inputs" : [ {
      "id" : 760,
      "points" : [ {
        "x" : 1108,
        "y" : 707
      } ]
    }, {
      "id" : 1579,
      "points" : [ {
        "x" : 1103,
        "y" : 677
      } ]
    } ],
    "outputs" : [ {
      "id" : 761
    } ]
  }, {
    "id" : 891,
    "reactomeId" : 870437,
    "displayName" : "USP9X (FAM) deubiquitinates SMAD4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 675,
      "y" : 277
    },
    "minX" : 644,
    "maxX" : 681,
    "minY" : 271,
    "maxY" : 310,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 644,
        "y" : 284
      },
      "to" : {
        "x" : 675,
        "y" : 277
      }
    }, {
      "from" : {
        "x" : 675,
        "y" : 277
      },
      "to" : {
        "x" : 681,
        "y" : 310
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 669,
        "y" : 271
      },
      "b" : {
        "x" : 681,
        "y" : 283
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 675,
        "y" : 277
      }
    },
    "inputs" : [ {
      "id" : 882,
      "points" : [ {
        "x" : 606,
        "y" : 273
      } ]
    }, {
      "id" : 1002,
      "points" : [ {
        "x" : 624,
        "y" : 294
      } ]
    } ],
    "outputs" : [ {
      "id" : 892,
      "points" : [ {
        "x" : 697,
        "y" : 365
      } ]
    }, {
      "id" : 881,
      "points" : [ {
        "x" : 652,
        "y" : 332
      } ]
    }, {
      "id" : 893,
      "points" : [ {
        "x" : 715,
        "y" : 299
      } ]
    } ],
    "catalysts" : [ {
      "id" : 882,
      "points" : [ {
        "x" : 606,
        "y" : 246
      }, {
        "x" : 648,
        "y" : 227
      } ]
    } ]
  }, {
    "id" : 1276,
    "reactomeId" : 209055,
    "displayName" : "PPM1A dephosphorylates nuclear SMAD2/3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1094,
      "y" : 453
    },
    "minX" : 1058,
    "maxX" : 1250,
    "minY" : 447,
    "maxY" : 505,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1058,
        "y" : 451
      },
      "to" : {
        "x" : 1094,
        "y" : 453
      }
    }, {
      "from" : {
        "x" : 1094,
        "y" : 453
      },
      "to" : {
        "x" : 1250,
        "y" : 505
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1088,
        "y" : 447
      },
      "b" : {
        "x" : 1100,
        "y" : 459
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1094,
        "y" : 453
      }
    },
    "inputs" : [ {
      "id" : 1277,
      "points" : [ {
        "x" : 1078,
        "y" : 472
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 1273,
      "points" : [ {
        "x" : 988,
        "y" : 456
      } ]
    } ],
    "outputs" : [ {
      "id" : 1278,
      "points" : [ {
        "x" : 1321,
        "y" : 479
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 840,
      "points" : [ {
        "x" : 1483,
        "y" : 733
      }, {
        "x" : 1489,
        "y" : 568
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 1272,
      "points" : [ {
        "x" : 978,
        "y" : 500
      } ]
    }, {
      "id" : 1279,
      "points" : [ {
        "x" : 1412,
        "y" : 511
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 1273,
      "points" : [ {
        "x" : 988,
        "y" : 448
      }, {
        "x" : 1060,
        "y" : 432
      } ]
    } ]
  }, {
    "id" : 1404,
    "reactomeId" : 9733247,
    "displayName" : "YBX1 binds COL1A2 gene promoter",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 664,
      "y" : 1381
    },
    "minX" : 634,
    "maxX" : 679,
    "minY" : 1347,
    "maxY" : 1415,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 679,
        "y" : 1347
      },
      "to" : {
        "x" : 664,
        "y" : 1381
      }
    }, {
      "from" : {
        "x" : 664,
        "y" : 1381
      },
      "to" : {
        "x" : 634,
        "y" : 1415
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 636,
        "y" : 1407
      },
      "b" : {
        "x" : 634,
        "y" : 1415
      },
      "c" : {
        "x" : 642,
        "y" : 1412
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 642,
        "y" : 1412
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 664,
        "y" : 1381
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 664,
        "y" : 1381
      }
    },
    "inputs" : [ {
      "id" : 1362,
      "points" : [ {
        "x" : 561,
        "y" : 1155
      } ]
    }, {
      "id" : 1405,
      "points" : [ {
        "x" : 758,
        "y" : 1357
      } ]
    }, {
      "id" : 1363,
      "points" : [ {
        "x" : 768,
        "y" : 1092
      }, {
        "x" : 819,
        "y" : 1309
      } ]
    } ],
    "outputs" : [ {
      "id" : 1406
    } ]
  } ],
  "compartments" : [ {
    "id" : 1,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1185,
      "y" : 859
    },
    "minX" : 0,
    "maxX" : 2370,
    "minY" : 36,
    "maxY" : 1683,
    "prop" : {
      "x" : 0,
      "y" : 36,
      "width" : 2370,
      "height" : 1647
    },
    "textPosition" : {
      "x" : 72,
      "y" : 1595
    },
    "insets" : {
      "x" : 20,
      "y" : 149,
      "width" : 2324,
      "height" : 1514
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 556, 557, 121, 880, 881, 882, 891, 892, 893, 895, 1002, 1283, 1297, 1298, 1299, 1309, 1310, 1311, 1312, 1313, 1434, 1435, 1437, 1639, 1640, 1205, 2039, 2041, 2042, 2043, 2044, 2045, 2220, 2221 ]
  }, {
    "id" : 2039,
    "reactomeId" : 17963,
    "displayName" : "Golgi lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 312,
      "y" : 658
    },
    "minX" : 239,
    "maxX" : 385,
    "minY" : 607,
    "maxY" : 709,
    "prop" : {
      "x" : 239,
      "y" : 607,
      "width" : 146,
      "height" : 102
    },
    "textPosition" : {
      "x" : 265,
      "y" : 662
    },
    "insets" : {
      "x" : 249,
      "y" : 617,
      "width" : 123,
      "height" : 81
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 1332 ]
  }, {
    "id" : 121,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1381,
      "y" : 1011
    },
    "minX" : 457,
    "maxX" : 2305,
    "minY" : 421,
    "maxY" : 1601,
    "prop" : {
      "x" : 457,
      "y" : 421,
      "width" : 1848,
      "height" : 1180
    },
    "textPosition" : {
      "x" : 476,
      "y" : 1527
    },
    "insets" : {
      "x" : 473,
      "y" : 436,
      "width" : 1811,
      "height" : 1144
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 599, 630, 570, 583, 590, 584, 598, 629, 597, 661, 662, 663, 681, 682, 687, 690, 711, 712, 713, 744, 745, 746, 755, 756, 759, 760, 761, 838, 840, 864, 861, 862, 869, 871, 873, 874, 918, 951, 952, 953, 954, 993, 994, 995, 1015, 1016, 1017, 1026, 1027, 1029, 1114, 1115, 1132, 1133, 1134, 1143, 1144, 1146, 1165, 1168, 1173, 1174, 1176, 1179, 1196, 1197, 1198, 1204, 1214, 1215, 1216, 1242, 1239, 1240, 1271, 1272, 1273, 1276, 1277, 1278, 1279, 1282, 1301, 1300, 1302, 1303, 1304, 1305, 1307, 1321, 1320, 1361, 1362, 1363, 1365, 1364, 1394, 1404, 1405, 1406, 1436, 1446, 1546, 1579, 1445, 1687, 1709, 1710, 1716, 1755, 1756, 1822, 1823, 1829, 1923, 1924, 1925, 1970, 1971, 1972, 1996, 2018, 2019, 2020, 2038, 2078, 2219 ]
  }, {
    "id" : 2221,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 296,
      "y" : 1229
    },
    "minX" : 171,
    "maxX" : 422,
    "minY" : 1134,
    "maxY" : 1325,
    "prop" : {
      "x" : 171,
      "y" : 1134,
      "width" : 251,
      "height" : 191
    },
    "textPosition" : {
      "x" : 189,
      "y" : 1172
    },
    "insets" : {
      "x" : 182,
      "y" : 1144,
      "width" : 230,
      "height" : 169
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 1395 ]
  } ],
  "notes" : [ {
    "id" : 1168,
    "displayName" : "Degradation",
    "renderableClass" : "Note",
    "position" : {
      "x" : 1974,
      "y" : 1059
    },
    "minX" : 1931,
    "maxX" : 2017,
    "minY" : 1046,
    "maxY" : 1073,
    "prop" : {
      "x" : 1931,
      "y" : 1046,
      "width" : 86,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1931,
      "y" : 1049
    }
  }, {
    "id" : 756,
    "displayName" : "Degradation",
    "renderableClass" : "Note",
    "position" : {
      "x" : 1428,
      "y" : 723
    },
    "minX" : 1385,
    "maxX" : 1471,
    "minY" : 710,
    "maxY" : 737,
    "prop" : {
      "x" : 1385,
      "y" : 710,
      "width" : 86,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1385,
      "y" : 713
    }
  }, {
    "id" : 1115,
    "displayName" : "Degradation",
    "renderableClass" : "Note",
    "position" : {
      "x" : 1377,
      "y" : 1120
    },
    "minX" : 1334,
    "maxX" : 1420,
    "minY" : 1107,
    "maxY" : 1134,
    "prop" : {
      "x" : 1334,
      "y" : 1107,
      "width" : 86,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1334,
      "y" : 1110
    }
  }, {
    "id" : 1996,
    "displayName" : "Degradation",
    "renderableClass" : "Note",
    "position" : {
      "x" : 772,
      "y" : 818
    },
    "minX" : 729,
    "maxX" : 815,
    "minY" : 805,
    "maxY" : 832,
    "prop" : {
      "x" : 729,
      "y" : 805,
      "width" : 86,
      "height" : 27
    },
    "textPosition" : {
      "x" : 729,
      "y" : 808
    }
  } ],
  "links" : [ {
    "id" : 1298,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 801,
      "y" : 150
    },
    "minX" : 795,
    "maxX" : 807,
    "minY" : 132,
    "maxY" : 168,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 801,
        "y" : 132
      },
      "to" : {
        "x" : 801,
        "y" : 168
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 797,
        "y" : 161
      },
      "b" : {
        "x" : 801,
        "y" : 168
      },
      "c" : {
        "x" : 805,
        "y" : 161
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 805,
        "y" : 161
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 795,
        "y" : 144
      },
      "b" : {
        "x" : 807,
        "y" : 156
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 801,
        "y" : 150
      }
    },
    "inputs" : [ {
      "id" : 1297
    } ],
    "outputs" : [ {
      "id" : 895
    } ]
  }, {
    "id" : 1299,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1837,
      "y" : 103
    },
    "minX" : 890,
    "maxX" : 1843,
    "minY" : 97,
    "maxY" : 814,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1840,
        "y" : 814
      },
      "to" : {
        "x" : 1837,
        "y" : 103
      }
    }, {
      "from" : {
        "x" : 1837,
        "y" : 103
      },
      "to" : {
        "x" : 890,
        "y" : 103
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 897,
        "y" : 99
      },
      "b" : {
        "x" : 890,
        "y" : 103
      },
      "c" : {
        "x" : 897,
        "y" : 107
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 897,
        "y" : 107
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1831,
        "y" : 97
      },
      "b" : {
        "x" : 1843,
        "y" : 109
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1837,
        "y" : 103
      }
    },
    "inputs" : [ {
      "id" : 584
    } ],
    "outputs" : [ {
      "id" : 1297
    } ]
  }, {
    "id" : 1300,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 933,
      "y" : 896
    },
    "minX" : 912,
    "maxX" : 1047,
    "minY" : 720,
    "maxY" : 1012,
    "segments" : [ {
      "from" : {
        "x" : 1047,
        "y" : 720
      },
      "to" : {
        "x" : 988,
        "y" : 728
      }
    }, {
      "from" : {
        "x" : 988,
        "y" : 728
      },
      "to" : {
        "x" : 912,
        "y" : 830
      }
    }, {
      "from" : {
        "x" : 912,
        "y" : 830
      },
      "to" : {
        "x" : 955,
        "y" : 963
      }
    }, {
      "from" : {
        "x" : 955,
        "y" : 963
      },
      "to" : {
        "x" : 952,
        "y" : 1003
      }
    }, {
      "from" : {
        "x" : 952,
        "y" : 1003
      },
      "to" : {
        "x" : 964,
        "y" : 1012
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 927,
        "y" : 890
      },
      "b" : {
        "x" : 939,
        "y" : 902
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 933,
        "y" : 896
      }
    },
    "inputs" : [ {
      "id" : 760
    } ],
    "outputs" : [ {
      "id" : 1016
    } ]
  }, {
    "id" : 1301,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1394,
      "y" : 1145
    },
    "minX" : 981,
    "maxX" : 1813,
    "minY" : 1002,
    "maxY" : 1151,
    "segments" : [ {
      "from" : {
        "x" : 1813,
        "y" : 1002
      },
      "to" : {
        "x" : 1803,
        "y" : 1144
      }
    }, {
      "from" : {
        "x" : 1803,
        "y" : 1144
      },
      "to" : {
        "x" : 985,
        "y" : 1147
      }
    }, {
      "from" : {
        "x" : 985,
        "y" : 1147
      },
      "to" : {
        "x" : 981,
        "y" : 1065
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1388,
        "y" : 1139
      },
      "b" : {
        "x" : 1400,
        "y" : 1151
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1394,
        "y" : 1145
      }
    },
    "inputs" : [ {
      "id" : 1133
    } ],
    "outputs" : [ {
      "id" : 1016
    } ]
  }, {
    "id" : 1446,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 826,
      "y" : 858
    },
    "minX" : 770,
    "maxX" : 882,
    "minY" : 677,
    "maxY" : 1039,
    "segments" : [ {
      "from" : {
        "x" : 770,
        "y" : 1039
      },
      "to" : {
        "x" : 882,
        "y" : 677
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 820,
        "y" : 852
      },
      "b" : {
        "x" : 832,
        "y" : 864
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 826,
        "y" : 858
      }
    },
    "inputs" : [ {
      "id" : 1363
    } ],
    "outputs" : [ {
      "id" : 1445
    } ]
  }, {
    "id" : 2042,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1000,
      "y" : 262
    },
    "minX" : 987,
    "maxX" : 1463,
    "minY" : 188,
    "maxY" : 359,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1463,
        "y" : 196
      },
      "to" : {
        "x" : 1014,
        "y" : 188
      }
    }, {
      "from" : {
        "x" : 1014,
        "y" : 188
      },
      "to" : {
        "x" : 987,
        "y" : 337
      }
    }, {
      "from" : {
        "x" : 987,
        "y" : 337
      },
      "to" : {
        "x" : 1062,
        "y" : 359
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1054,
        "y" : 361
      },
      "b" : {
        "x" : 1062,
        "y" : 359
      },
      "c" : {
        "x" : 1056,
        "y" : 353
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1056,
        "y" : 353
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 994,
        "y" : 256
      },
      "b" : {
        "x" : 1006,
        "y" : 268
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1000,
        "y" : 262
      }
    },
    "inputs" : [ {
      "id" : 2041
    } ],
    "outputs" : [ {
      "id" : 1313
    } ]
  }, {
    "id" : 2043,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1641,
      "y" : 340
    },
    "minX" : 1577,
    "maxX" : 1647,
    "minY" : 227,
    "maxY" : 688,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1577,
        "y" : 227
      },
      "to" : {
        "x" : 1641,
        "y" : 340
      }
    }, {
      "from" : {
        "x" : 1641,
        "y" : 340
      },
      "to" : {
        "x" : 1641,
        "y" : 688
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1637,
        "y" : 681
      },
      "b" : {
        "x" : 1641,
        "y" : 688
      },
      "c" : {
        "x" : 1645,
        "y" : 681
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1645,
        "y" : 681
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1635,
        "y" : 334
      },
      "b" : {
        "x" : 1647,
        "y" : 346
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1641,
        "y" : 340
      }
    },
    "inputs" : [ {
      "id" : 2041
    } ],
    "outputs" : [ {
      "id" : 1321
    } ]
  }, {
    "id" : 2045,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 322,
      "y" : 39
    },
    "minX" : 247,
    "maxX" : 397,
    "minY" : 33,
    "maxY" : 46,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 247,
        "y" : 46
      },
      "to" : {
        "x" : 397,
        "y" : 33
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 390,
        "y" : 38
      },
      "b" : {
        "x" : 397,
        "y" : 33
      },
      "c" : {
        "x" : 390,
        "y" : 30
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 390,
        "y" : 30
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 316,
        "y" : 33
      },
      "b" : {
        "x" : 328,
        "y" : 45
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 322,
        "y" : 39
      }
    },
    "inputs" : [ {
      "id" : 1640
    } ],
    "outputs" : [ {
      "id" : 2044
    } ]
  } ],
  "shadows" : [ {
    "id" : 2222,
    "reactomeId" : 2173795,
    "displayName" : "Downregulation of SMAD2/3:SMAD4 transcriptional activity",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1304,
      "y" : 688
    },
    "minX" : 490,
    "maxX" : 2119,
    "minY" : 236,
    "maxY" : 1141,
    "prop" : {
      "x" : 490,
      "y" : 236,
      "width" : 1629,
      "height" : 905
    },
    "points" : [ {
      "x" : 490,
      "y" : 236
    }, {
      "x" : 2119,
      "y" : 236
    }, {
      "x" : 2119,
      "y" : 1141
    }, {
      "x" : 490,
      "y" : 1141
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 2223,
    "reactomeId" : 2173796,
    "displayName" : "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1129,
      "y" : 893
    },
    "minX" : 191,
    "maxX" : 2067,
    "minY" : 27,
    "maxY" : 1760,
    "prop" : {
      "x" : 191,
      "y" : 1141,
      "width" : 1876,
      "height" : 619
    },
    "points" : [ {
      "x" : 191,
      "y" : 27
    }, {
      "x" : 2067,
      "y" : 27
    }, {
      "x" : 2067,
      "y" : 1760
    }, {
      "x" : 191,
      "y" : 1760
    } ],
    "colour" : "#dc3912"
  } ],
  "minX" : 0,
  "maxX" : 2370,
  "minY" : 0,
  "maxY" : 1750,
  "disease" : false
}