{ "dbId" : 174824, "stId" : "R-HSA-174824", "speciesName" : "Homo sapiens", "nodes" : [ { "dbId" : 174594, "stId" : "R-HSA-174594", "displayName" : "chylomicron remnant:apoE complex [endosome lumen]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 317 ], "parents" : [ ], "children" : [ 174805, 174804 ] }, { "dbId" : 174592, "stId" : "R-HSA-174592", "displayName" : "LPL dimer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 153 ], "parents" : [ 8867477 ], "children" : [ 174605 ] }, { "dbId" : 174593, "stId" : "R-HSA-174593", "displayName" : "ApoB-48:TG:PL complex [endosome lumen]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 174805 ], "children" : [ 174716, 171150, 171144 ] }, { "dbId" : 174602, "stId" : "R-ALL-174602", "displayName" : "LCFAs [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 208, 516 ], "identifier" : "15904", "standardIdentifier" : "chebi:15904", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 8858255, "stId" : "R-HSA-8858255", "displayName" : "HDLBP:HDL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 434 ], "parents" : [ ], "children" : [ 8858026, 265523 ] }, { "dbId" : 174603, "stId" : "R-HSA-174603", "displayName" : "LIPC [extracellular matrix]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 308 ], "identifier" : "P11150", "standardIdentifier" : "uniprot:P11150", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LIPC", "HTGL" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 6784618, "stId" : "R-HSA-6784618", "displayName" : "FURIN,PCSK6 [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 167 ], "parents" : [ ], "children" : [ 1181103, 6784630 ] }, { "dbId" : 6784617, "stId" : "R-HSA-6784617", "displayName" : "MBTPS2 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O43462", "standardIdentifier" : "uniprot:O43462", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MBTPS2", "S2P" ], "parents" : [ 6784711 ], "children" : [ ] }, { "dbId" : 8855688, "stId" : "R-HSA-8855688", "displayName" : "enlarged spherical HDL [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 273 ], "parents" : [ ], "children" : [ 171149, 171066, 171076, 171126, 174720 ] }, { "dbId" : 174605, "stId" : "R-HSA-174605", "displayName" : "LPL [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 166 ], "identifier" : "P06858", "standardIdentifier" : "uniprot:P06858", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LPL", "LIPD" ], "parents" : [ 174592 ], "children" : [ ] }, { "dbId" : 6784630, "stId" : "R-HSA-6784630", "displayName" : "PCSK6 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P29122", "standardIdentifier" : "uniprot:P29122", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PCSK6", "PACE4" ], "parents" : [ 6784618 ], "children" : [ ] }, { "dbId" : 8876694, "stId" : "R-HSA-8876694", "displayName" : "SOAT1,2 [endoplasmic reticulum membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 386 ], "parents" : [ ], "children" : [ 8876490, 8876492 ] }, { "dbId" : 8867477, "stId" : "R-HSA-8867477", "displayName" : "HSPG:LPL dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 155 ], "parents" : [ 8857969 ], "children" : [ 1678620, 174592 ] }, { "dbId" : 174608, "stId" : "R-HSA-174608", "displayName" : "APOA5 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 210 ], "identifier" : "Q6Q788", "standardIdentifier" : "uniprot:Q6Q788", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOA5", "RAP3", "UNQ411/PRO773" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 6784629, "stId" : "R-HSA-6784629", "displayName" : "CREB3L3(1-?) [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 184 ], "identifier" : "Q68CJ9", "standardIdentifier" : "uniprot:Q68CJ9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CREB3L3", "CREBH", "HYST1481" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 6784626, "stId" : "R-HSA-6784626", "displayName" : "FGF21 gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "ENSG00000105550", "standardIdentifier" : "ensembl:ENSG00000105550", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "FGF21", "UNQ3115/PRO10196" ], "parents" : [ 6784668 ], "children" : [ ] }, { "dbId" : 174615, "stId" : "R-HSA-174615", "displayName" : "APOE [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P02649", "standardIdentifier" : "uniprot:P02649", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOE" ], "parents" : [ 174797, 174659 ], "children" : [ ] }, { "dbId" : 6785148, "stId" : "R-HSA-6785148", "displayName" : "LMF1,2 [endoplasmic reticulum membrane]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 191 ], "parents" : [ 6785173 ], "children" : [ 6785145, 6785147 ] }, { "dbId" : 6785147, "stId" : "R-HSA-6785147", "displayName" : "LMF2 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9BU23", "standardIdentifier" : "uniprot:Q9BU23", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LMF2", "TMEM112B", "TMEM153" ], "parents" : [ 6785148 ], "children" : [ ] }, { "dbId" : 174620, "stId" : "R-HSA-174620", "displayName" : "APOB(28-2179) [endoplasmic reticulum lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 7 ], "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 174756 ], "children" : [ ] }, { "dbId" : 6785145, "stId" : "R-HSA-6785145", "displayName" : "LMF1 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q96S06", "standardIdentifier" : "uniprot:Q96S06", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LMF1", "C16orf26", "TMEM112", "HMFN1876", "JFP11" ], "parents" : [ 6785148 ], "children" : [ ] }, { "dbId" : 174626, "stId" : "R-HSA-174626", "displayName" : "nascent chylomicron [endoplasmic reticulum lumen]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 15 ], "parents" : [ ], "children" : [ 174636, 174648, 174667, 174756, 174689, 174672, 174640 ] }, { "dbId" : 174625, "stId" : "R-HSA-174625", "displayName" : "APOB(28-2179) [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 174666 ], "children" : [ ] }, { "dbId" : 174630, "stId" : "R-HSA-174630", "displayName" : "ApoB-48:TG:PL complex [endoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 5 ], "parents" : [ ], "children" : [ 174637, 174671, 174779 ] }, { "dbId" : 171044, "stId" : "R-HSA-171044", "displayName" : "LDL [endosome membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 171056 ], "children" : [ 171148, 171135, 171061, 171093, 171121 ] }, { "dbId" : 5694065, "stId" : "R-HSA-5694065", "displayName" : "LIPC [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P11150", "standardIdentifier" : "uniprot:P11150", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LIPC", "HTGL" ], "parents" : [ 6785179 ], "children" : [ ] }, { "dbId" : 8876704, "stId" : "R-ALL-8876704", "displayName" : "CHEST [endoplasmic reticulum membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 385 ], "identifier" : "17002", "standardIdentifier" : "chebi:17002", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 8848047, "stId" : "R-ALL-8848047", "displayName" : "CHOL [lysosomal lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 365 ], "identifier" : "16113", "standardIdentifier" : "chebi:16113", "referenceType" : "ReferenceMolecule", "parents" : [ 8876460, 8876367, 8876365 ], "children" : [ ] }, { "dbId" : 158255, "stId" : "R-HSA-158255", "displayName" : "A2M tetramer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 85 ], "parents" : [ ], "children" : [ 49291 ] }, { "dbId" : 174636, "stId" : "R-ALL-174636", "displayName" : "CHEST [endoplasmic reticulum lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 8 ], "identifier" : "17002", "standardIdentifier" : "chebi:17002", "referenceType" : "ReferenceMolecule", "parents" : [ 174626 ], "children" : [ ] }, { "dbId" : 174637, "stId" : "R-HSA-174637", "displayName" : "APOB(28-2179) [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 4 ], "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 174630 ], "children" : [ ] }, { "dbId" : 171053, "stId" : "R-HSA-171053", "displayName" : "LDLR [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 306, 340 ], "identifier" : "P01130", "standardIdentifier" : "uniprot:P01130", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LDLR" ], "parents" : [ 6784730, 171100, 174749 ], "children" : [ ] }, { "dbId" : 174643, "stId" : "R-HSA-174643", "displayName" : "spherical HDL:apoC-II:apoC-III:apoE [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 18, 271 ], "parents" : [ ], "children" : [ 174699, 174725, 265523, 174646 ] }, { "dbId" : 174640, "stId" : "R-HSA-174640", "displayName" : "APOA1(25-267) [endoplasmic reticulum lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 14 ], "identifier" : "P02647", "standardIdentifier" : "uniprot:P02647", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOA1" ], "parents" : [ 174626 ], "children" : [ ] }, { "dbId" : 171056, "stId" : "R-HSA-171056", "displayName" : "LDL:LDLR complex [endosome membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 351 ], "parents" : [ ], "children" : [ 171044, 171127 ] }, { "dbId" : 264759, "stId" : "R-HSA-264759", "displayName" : "BMP1-3:Zn2+ [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 84 ], "parents" : [ ], "children" : [ 264768, 158417 ] }, { "dbId" : 171057, "stId" : "R-ALL-171057", "displayName" : "TAGs [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 504 ], "identifier" : "17855", "standardIdentifier" : "chebi:17855", "referenceType" : "ReferenceMolecule", "parents" : [ 171112, 174666, 174797, 349644 ], "children" : [ ] }, { "dbId" : 174646, "stId" : "R-HSA-174646", "displayName" : "APOE [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 220, 269 ], "identifier" : "P02649", "standardIdentifier" : "uniprot:P02649", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOE" ], "parents" : [ 174792, 174807, 174798, 174697, 174643 ], "children" : [ ] }, { "dbId" : 171061, "stId" : "R-ALL-171061", "displayName" : "cholesterol esters [endosome membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "17002", "standardIdentifier" : "chebi:17002", "referenceType" : "ReferenceMolecule", "parents" : [ 174795, 171044 ], "children" : [ ] }, { "dbId" : 171066, "stId" : "R-ALL-171066", "displayName" : "PL [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "16247", "standardIdentifier" : "chebi:16247", "referenceType" : "ReferenceMolecule", "parents" : [ 8855688, 266351, 266340, 174729, 349645, 8866325, 171131, 265523, 216752 ], "children" : [ ] }, { "dbId" : 174651, "stId" : "R-HSA-174651", "displayName" : "APOE [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P02649", "standardIdentifier" : "uniprot:P02649", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOE" ], "parents" : [ 174649, 174787 ], "children" : [ ] }, { "dbId" : 174648, "stId" : "R-ALL-174648", "displayName" : "TAGs [endoplasmic reticulum lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 13 ], "identifier" : "17855", "standardIdentifier" : "chebi:17855", "referenceType" : "ReferenceMolecule", "parents" : [ 174626, 174756, 174681 ], "children" : [ ] }, { "dbId" : 171065, "stId" : "R-HSA-171065", "displayName" : "APOB(28-4563) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 8866325, 171131 ], "children" : [ ] }, { "dbId" : 174649, "stId" : "R-HSA-174649", "displayName" : "chylomicron remnant [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 174787 ], "children" : [ 171069, 171068, 174651, 174746, 171107 ] }, { "dbId" : 8876730, "stId" : "R-ALL-8876730", "displayName" : "LCFA(-) [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 398 ], "identifier" : "57560", "standardIdentifier" : "chebi:57560", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 171068, "stId" : "R-ALL-171068", "displayName" : "TAGs [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "17855", "standardIdentifier" : "chebi:17855", "referenceType" : "ReferenceMolecule", "parents" : [ 171156, 174649, 174746 ], "children" : [ ] }, { "dbId" : 171069, "stId" : "R-ALL-171069", "displayName" : "cholesterol [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "16113", "standardIdentifier" : "chebi:16113", "referenceType" : "ReferenceMolecule", "parents" : [ 171156, 174649 ], "children" : [ ] }, { "dbId" : 266308, "stId" : "R-HSA-266308", "displayName" : "LCAT:spherical HDL complex [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 290 ], "parents" : [ ], "children" : [ 194239, 265523 ] }, { "dbId" : 174658, "stId" : "R-HSA-174658", "displayName" : "chylomicron remnant:apoE:LDLR complex [endosome membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 313 ], "parents" : [ ], "children" : [ 174698, 171127 ] }, { "dbId" : 194115, "stId" : "R-HSA-194115", "displayName" : "ALB [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 287 ], "identifier" : "P02768", "standardIdentifier" : "uniprot:P02768", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ALB", "GIG20", "GIG42", "PRO0903", "PRO1708", "PRO2044", "PRO2619", "PRO2675", "UNQ696/PRO1341" ], "parents" : [ 264677 ], "children" : [ ] }, { "dbId" : 174659, "stId" : "R-HSA-174659", "displayName" : "chylomicron remnant:apoE complex [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 174749 ], "children" : [ 174797, 174615 ] }, { "dbId" : 171075, "stId" : "R-ALL-171075", "displayName" : "cholesterol esters [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 503 ], "identifier" : "17002", "standardIdentifier" : "chebi:17002", "referenceType" : "ReferenceMolecule", "parents" : [ 171112, 349644 ], "children" : [ ] }, { "dbId" : 444999, "stId" : "R-HSA-444999", "displayName" : "Adaptor protein complex 2 (AP-2) large adaptins [plasma membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 177480 ], "children" : [ 177502, 177494 ] }, { "dbId" : 264768, "stId" : "R-HSA-264768", "displayName" : "BMP1-3 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P13497-3", "standardIdentifier" : "uniprot:P13497-3", "referenceType" : "ReferenceIsoform", "geneNames" : [ "BMP1", "PCOLC" ], "parents" : [ 264759 ], "children" : [ ] }, { "dbId" : 171076, "stId" : "R-ALL-171076", "displayName" : "CHEST [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 281 ], "identifier" : "17002", "standardIdentifier" : "chebi:17002", "referenceType" : "ReferenceMolecule", "parents" : [ 174797, 174807, 174798, 8855688, 266339, 266340, 174697, 174791, 349645, 8866325, 171131, 265523 ], "children" : [ ] }, { "dbId" : 264771, "stId" : "R-HSA-264771", "displayName" : "APOA1(19-267) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 82 ], "identifier" : "P02647", "standardIdentifier" : "uniprot:P02647", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOA1" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 174666, "stId" : "R-HSA-174666", "displayName" : "ApoB-48:TG:PL complex [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 174797 ], "children" : [ 171142, 171057, 174625 ] }, { "dbId" : 171082, "stId" : "R-HSA-171082", "displayName" : "LDL [endosome lumen]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 355 ], "parents" : [ ], "children" : [ 171119, 171150, 171144, 171083, 171123 ] }, { "dbId" : 174667, "stId" : "R-HSA-174667", "displayName" : "APOA4 [endoplasmic reticulum lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 12 ], "identifier" : "P06727", "standardIdentifier" : "uniprot:P06727", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOA4" ], "parents" : [ 174626 ], "children" : [ ] }, { "dbId" : 171083, "stId" : "R-ALL-171083", "displayName" : "cholesterol [endosome lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "16113", "standardIdentifier" : "chebi:16113", "referenceType" : "ReferenceMolecule", "parents" : [ 174805, 171082 ], "children" : [ ] }, { "dbId" : 1605715, "stId" : "R-ALL-1605715", "displayName" : "H2O [lysosomal lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 362 ], "identifier" : "15377", "standardIdentifier" : "chebi:15377", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 174671, "stId" : "R-ALL-174671", "displayName" : "PL [endoplasmic reticulum membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 3, 46 ], "identifier" : "16247", "standardIdentifier" : "chebi:16247", "referenceType" : "ReferenceMolecule", "parents" : [ 174630, 6784871 ], "children" : [ ] }, { "dbId" : 382539, "stId" : "R-ALL-382539", "displayName" : "PC [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 1013 ], "identifier" : "57643", "standardIdentifier" : "chebi:57643", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 174675, "stId" : "R-ALL-174675", "displayName" : "DAGs [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 514, 214, 205 ], "identifier" : "18035", "standardIdentifier" : "chebi:18035", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 174672, "stId" : "R-ALL-174672", "displayName" : "CHOL [endoplasmic reticulum lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 10 ], "identifier" : "16113", "standardIdentifier" : "chebi:16113", "referenceType" : "ReferenceMolecule", "parents" : [ 174626 ], "children" : [ ] }, { "dbId" : 5649925, "stId" : "R-HSA-5649925", "displayName" : "APOA5 gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "ENSG00000110243", "standardIdentifier" : "ensembl:ENSG00000110243", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "APOA5", "RAP3", "UNQ411/PRO773" ], "parents" : [ 6784668 ], "children" : [ ] }, { "dbId" : 171089, "stId" : "R-HSA-171089", "displayName" : "APOB(28-4563) [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 171112 ], "children" : [ ] }, { "dbId" : 174678, "stId" : "R-HSA-174678", "displayName" : "SAR1B [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 17 ], "identifier" : "Q9Y6B6", "standardIdentifier" : "uniprot:Q9Y6B6", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SAR1B", "SARA2", "SARB" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 171095, "stId" : "R-ALL-171095", "displayName" : "CHOL [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 122, 506, 253 ], "identifier" : "16113", "standardIdentifier" : "chebi:16113", "referenceType" : "ReferenceMolecule", "parents" : [ 171112, 174797, 349644 ], "children" : [ ] }, { "dbId" : 171093, "stId" : "R-ALL-171093", "displayName" : "TAGs [endosome membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "17855", "standardIdentifier" : "chebi:17855", "referenceType" : "ReferenceMolecule", "parents" : [ 174799, 174795, 171044 ], "children" : [ ] }, { "dbId" : 2395773, "stId" : "R-HSA-2395773", "displayName" : "APOA4 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P06727", "standardIdentifier" : "uniprot:P06727", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOA4" ], "parents" : [ 6784718 ], "children" : [ ] }, { "dbId" : 450143, "stId" : "R-HSA-450143", "displayName" : "K63-Ub [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 1012 ], "parents" : [ ], "children" : [ 939182, 939212, 939176, 939241, 939206, 939173, 939235, 939168, 939169, 939198, 939224, 939254, 939186, 939248 ] }, { "dbId" : 174681, "stId" : "R-HSA-174681", "displayName" : "MTTP:PDI:lipid complex [endoplasmic reticulum lumen]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 6, 44 ], "parents" : [ 9737771 ], "children" : [ 174648, 174692, 174694, 174688 ] }, { "dbId" : 171100, "stId" : "R-HSA-171100", "displayName" : "LDL:LDLR complex [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 338 ], "parents" : [ ], "children" : [ 171053, 171112 ] }, { "dbId" : 266340, "stId" : "R-HSA-266340", "displayName" : "CETP:cholesterol ester [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 229 ], "parents" : [ ], "children" : [ 171066, 171076, 194231 ] }, { "dbId" : 171107, "stId" : "R-ALL-171107", "displayName" : "cholesterol esters [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "17002", "standardIdentifier" : "chebi:17002", "referenceType" : "ReferenceMolecule", "parents" : [ 171156, 174649 ], "children" : [ ] }, { "dbId" : 174688, "stId" : "R-HSA-174688", "displayName" : "MTTP [endoplasmic reticulum lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P55157", "standardIdentifier" : "uniprot:P55157", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MTTP", "MTP" ], "parents" : [ 174681 ], "children" : [ ] }, { "dbId" : 174689, "stId" : "R-HSA-174689", "displayName" : "APOA2(24-100) [endoplasmic reticulum lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 9 ], "identifier" : "P02652", "standardIdentifier" : "uniprot:P02652", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOA2" ], "parents" : [ 174626 ], "children" : [ ] }, { "dbId" : 171105, "stId" : "R-HSA-171105", "displayName" : "LDLR [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P01130", "standardIdentifier" : "uniprot:P01130", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LDLR" ], "parents" : [ 171108, 174816 ], "children" : [ ] }, { "dbId" : 174694, "stId" : "R-ALL-174694", "displayName" : "PL [endoplasmic reticulum lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "16247", "standardIdentifier" : "chebi:16247", "referenceType" : "ReferenceMolecule", "parents" : [ 174756, 174681 ], "children" : [ ] }, { "dbId" : 174692, "stId" : "R-HSA-174692", "displayName" : "P4HB [endoplasmic reticulum lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P07237", "standardIdentifier" : "uniprot:P07237", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "P4HB", "ERBA2L", "PDI", "PDIA1", "PO4DB" ], "parents" : [ 174681 ], "children" : [ ] }, { "dbId" : 171108, "stId" : "R-HSA-171108", "displayName" : "LDL:LDLR complex [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 347 ], "parents" : [ ], "children" : [ 171156, 171105 ] }, { "dbId" : 266339, "stId" : "R-HSA-266339", "displayName" : "LDL:cholesterol ester [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 231 ], "parents" : [ ], "children" : [ 171131, 171076 ] }, { "dbId" : 266348, "stId" : "R-HSA-266348", "displayName" : "spherical HDL:triacylglycerol complex [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 295 ], "parents" : [ ], "children" : [ 265523, 171126 ] }, { "dbId" : 174698, "stId" : "R-HSA-174698", "displayName" : "chylomicron remnant:apoE complex [endosome membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 174658 ], "children" : [ 174766, 174795 ] }, { "dbId" : 174699, "stId" : "R-HSA-174699", "displayName" : "APOC2 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 211, 267 ], "identifier" : "P02655", "standardIdentifier" : "uniprot:P02655", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOC2", "APC2" ], "parents" : [ 174769, 174798, 174697, 174643 ], "children" : [ ] }, { "dbId" : 171112, "stId" : "R-HSA-171112", "displayName" : "LDL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 171100 ], "children" : [ 171095, 171142, 171057, 171089, 171075 ] }, { "dbId" : 174697, "stId" : "R-HSA-174697", "displayName" : "chylomicron [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 20 ], "parents" : [ ], "children" : [ 171149, 174701, 174729, 174699, 174725, 171076, 174775, 174646, 171126, 174720 ] }, { "dbId" : 266351, "stId" : "R-HSA-266351", "displayName" : "CETP:triacylglycerol [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 230 ], "parents" : [ 349410 ], "children" : [ 171066, 194231, 171126 ] }, { "dbId" : 171119, "stId" : "R-HSA-171119", "displayName" : "APOB(28-4563) [endosome lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 171082 ], "children" : [ ] }, { "dbId" : 174701, "stId" : "R-HSA-174701", "displayName" : "APOA4 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P06727", "standardIdentifier" : "uniprot:P06727", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOA4" ], "parents" : [ 174769, 174798, 174697, 174791 ], "children" : [ ] }, { "dbId" : 6797334, "stId" : "R-HSA-6797334", "displayName" : "MBTPS1 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q14703", "standardIdentifier" : "uniprot:Q14703", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MBTPS1", "KIAA0091", "S1P", "SKI1" ], "parents" : [ 6784711 ], "children" : [ ] }, { "dbId" : 171123, "stId" : "R-ALL-171123", "displayName" : "cholesterol esters [endosome lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "17002", "standardIdentifier" : "chebi:17002", "referenceType" : "ReferenceMolecule", "parents" : [ 174805, 171082 ], "children" : [ ] }, { "dbId" : 171121, "stId" : "R-HSA-171121", "displayName" : "APOB(28-4563) [endosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 171044 ], "children" : [ ] }, { "dbId" : 171126, "stId" : "R-ALL-171126", "displayName" : "TAGs [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 202, 523 ], "identifier" : "17855", "standardIdentifier" : "chebi:17855", "referenceType" : "ReferenceMolecule", "parents" : [ 174807, 174798, 8855688, 266348, 266351, 174697, 174729, 174791, 8866325, 171131, 265523 ], "children" : [ ] }, { "dbId" : 171127, "stId" : "R-HSA-171127", "displayName" : "LDLR [endosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 357, 316 ], "identifier" : "P01130", "standardIdentifier" : "uniprot:P01130", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LDLR" ], "parents" : [ 174658, 171056 ], "children" : [ ] }, { "dbId" : 171131, "stId" : "R-HSA-171131", "displayName" : "LDL [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 228 ], "parents" : [ 8933254, 176866, 266339 ], "children" : [ 171149, 171065, 171066, 171076, 171126 ] }, { "dbId" : 264830, "stId" : "R-HSA-264830", "displayName" : "CUBN:AMN [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 454 ], "parents" : [ 264851 ], "children" : [ 264843, 264825 ] }, { "dbId" : 171135, "stId" : "R-ALL-171135", "displayName" : "cholesterol [endosome membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "16113", "standardIdentifier" : "chebi:16113", "referenceType" : "ReferenceMolecule", "parents" : [ 174795, 171044 ], "children" : [ ] }, { "dbId" : 264825, "stId" : "R-HSA-264825", "displayName" : "AMN [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9BXJ7", "standardIdentifier" : "uniprot:Q9BXJ7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AMN", "UNQ513/PRO1028" ], "parents" : [ 264830 ], "children" : [ ] }, { "dbId" : 174716, "stId" : "R-HSA-174716", "displayName" : "APOB(28-2179) [endosome lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 174593 ], "children" : [ ] }, { "dbId" : 8866311, "stId" : "R-HSA-8866311", "displayName" : "pre-VLDL [smooth endoplasmic reticulum]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 56 ], "parents" : [ 8866319 ], "children" : [ 8866317, 8866307, 8866324 ] }, { "dbId" : 171138, "stId" : "R-ALL-171138", "displayName" : "PL [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "16247", "standardIdentifier" : "chebi:16247", "referenceType" : "ReferenceMolecule", "parents" : [ 171156, 174746 ], "children" : [ ] }, { "dbId" : 174720, "stId" : "R-HSA-174720", "displayName" : "APOA1(25-267) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 83, 457, 284 ], "identifier" : "P02647", "standardIdentifier" : "uniprot:P02647", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOA1" ], "parents" : [ 174769, 174798, 8855688, 174697, 174791, 349645, 216752, 265523 ], "children" : [ ] }, { "dbId" : 8866307, "stId" : "R-ALL-8866307", "displayName" : "TAG [smooth endoplasmic reticulum]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 58 ], "identifier" : "17855", "standardIdentifier" : "chebi:17855", "referenceType" : "ReferenceMolecule", "parents" : [ 8866319, 8866311 ], "children" : [ ] }, { "dbId" : 171142, "stId" : "R-ALL-171142", "displayName" : "PL [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 276, 134, 508 ], "identifier" : "16247", "standardIdentifier" : "chebi:16247", "referenceType" : "ReferenceMolecule", "parents" : [ 171112, 174666, 349644 ], "children" : [ ] }, { "dbId" : 171143, "stId" : "R-HSA-171143", "displayName" : "LDLRAP1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 311, 349 ], "identifier" : "Q5SW96", "standardIdentifier" : "uniprot:Q5SW96", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LDLRAP1", "ARH" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 8866305, "stId" : "R-ALL-8866305", "displayName" : "CHOL [smooth endoplasmic reticulum]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 59 ], "identifier" : "16113", "standardIdentifier" : "chebi:16113", "referenceType" : "ReferenceMolecule", "parents" : [ 8866319 ], "children" : [ ] }, { "dbId" : 174725, "stId" : "R-HSA-174725", "displayName" : "APOC3 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 212, 266 ], "identifier" : "P02656", "standardIdentifier" : "uniprot:P02656", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOC3" ], "parents" : [ 174769, 174798, 174697, 174643 ], "children" : [ ] }, { "dbId" : 8866319, "stId" : "R-HSA-8866319", "displayName" : "VLDL [smooth endoplasmic reticulum]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 62 ], "parents" : [ ], "children" : [ 8866316, 8866305, 8866307, 8866324, 8866311 ] }, { "dbId" : 8866317, "stId" : "R-HSA-8866317", "displayName" : "APOB(28-4563) [smooth endoplasmic reticulum]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 8866311 ], "children" : [ ] }, { "dbId" : 171144, "stId" : "R-ALL-171144", "displayName" : "TAGs [endosome lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "17855", "standardIdentifier" : "chebi:17855", "referenceType" : "ReferenceMolecule", "parents" : [ 174805, 174593, 171082 ], "children" : [ ] }, { "dbId" : 8866316, "stId" : "R-ALL-8866316", "displayName" : "CHEST [smooth endoplasmic reticulum]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 61 ], "identifier" : "17002", "standardIdentifier" : "chebi:17002", "referenceType" : "ReferenceMolecule", "parents" : [ 8866319 ], "children" : [ ] }, { "dbId" : 49291, "stId" : "R-HSA-49291", "displayName" : "A2M [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P01023", "standardIdentifier" : "uniprot:P01023", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "A2M", "CPAMD5", "FWP007" ], "parents" : [ 158255 ], "children" : [ ] }, { "dbId" : 174729, "stId" : "R-HSA-174729", "displayName" : "ApoB-48:TG:PL complex [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 174807, 174798, 174697, 174791 ], "children" : [ 171066, 171126, 174770 ] }, { "dbId" : 171150, "stId" : "R-ALL-171150", "displayName" : "PL [endosome lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "16247", "standardIdentifier" : "chebi:16247", "referenceType" : "ReferenceMolecule", "parents" : [ 174593, 171082 ], "children" : [ ] }, { "dbId" : 422024, "stId" : "R-ALL-422024", "displayName" : "FAs [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 204 ], "identifier" : "35366", "standardIdentifier" : "chebi:35366", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 171148, "stId" : "R-ALL-171148", "displayName" : "PL [endosome membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "16247", "standardIdentifier" : "chebi:16247", "referenceType" : "ReferenceMolecule", "parents" : [ 174799, 171044 ], "children" : [ ] }, { "dbId" : 171149, "stId" : "R-ALL-171149", "displayName" : "CHOL [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 278 ], "identifier" : "16113", "standardIdentifier" : "chebi:16113", "referenceType" : "ReferenceMolecule", "parents" : [ 174807, 174798, 8855688, 266083, 174697, 174791, 349645, 8866325, 171131, 265523, 216752 ], "children" : [ ] }, { "dbId" : 264843, "stId" : "R-HSA-264843", "displayName" : "CUBN [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O60494", "standardIdentifier" : "uniprot:O60494", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CUBN", "IFCR" ], "parents" : [ 264830 ], "children" : [ ] }, { "dbId" : 171155, "stId" : "R-HSA-171155", "displayName" : "APOB(28-4563) [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 171156 ], "children" : [ ] }, { "dbId" : 8866325, "stId" : "R-HSA-8866325", "displayName" : "VLDL (-APOC1,C4) [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 67 ], "parents" : [ 8855875 ], "children" : [ 171149, 171065, 171066, 171076, 171126 ] }, { "dbId" : 8866324, "stId" : "R-ALL-8866324", "displayName" : "PL [smooth endoplasmic reticulum]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 60 ], "identifier" : "16247", "standardIdentifier" : "chebi:16247", "referenceType" : "ReferenceMolecule", "parents" : [ 8866319, 8866311 ], "children" : [ ] }, { "dbId" : 171156, "stId" : "R-HSA-171156", "displayName" : "LDL [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 171108 ], "children" : [ 171069, 171068, 171107, 171155, 171138 ] }, { "dbId" : 264851, "stId" : "R-HSA-264851", "displayName" : "apoA-I:CUBN:AMN complex [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 455 ], "parents" : [ ], "children" : [ 264830, 216742 ] }, { "dbId" : 174746, "stId" : "R-HSA-174746", "displayName" : "ApoB-48:TG:PL complex [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 174649 ], "children" : [ 171068, 174788, 171138 ] }, { "dbId" : 194203, "stId" : "R-HSA-194203", "displayName" : "PLTP-2 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P55058-2", "standardIdentifier" : "uniprot:P55058-2", "referenceType" : "ReferenceIsoform", "geneNames" : [ "PLTP" ], "parents" : [ 194227 ], "children" : [ ] }, { "dbId" : 174749, "stId" : "R-HSA-174749", "displayName" : "chylomicron remnant:apoE:LDLR complex [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 307 ], "parents" : [ ], "children" : [ 171053, 174659 ] }, { "dbId" : 6784711, "stId" : "R-HSA-6784711", "displayName" : "MBTPS1,2 [endoplasmic reticulum membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 177 ], "parents" : [ ], "children" : [ 6784617, 6797334 ] }, { "dbId" : 939182, "stId" : "R-HSA-939182", "displayName" : "Ub-443-UBC(381-456) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 6789318, "stId" : "R-HSA-6789318", "displayName" : "LIPG [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9Y5X9", "standardIdentifier" : "uniprot:Q9Y5X9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LIPG", "UNQ387/PRO719" ], "parents" : [ 6789313 ], "children" : [ ] }, { "dbId" : 6784710, "stId" : "R-HSA-6784710", "displayName" : "CREB3L3(?-461) [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 175 ], "identifier" : "Q68CJ9", "standardIdentifier" : "uniprot:Q68CJ9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CREB3L3", "CREBH", "HYST1481" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 167585, "stId" : "R-HSA-167585", "displayName" : "AP2M1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q96CW1", "standardIdentifier" : "uniprot:Q96CW1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AP2M1", "CLAPM1", "KIAA0109" ], "parents" : [ 177480 ], "children" : [ ] }, { "dbId" : 216742, "stId" : "R-HSA-216742", "displayName" : "APOA1(25-267) [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P02647", "standardIdentifier" : "uniprot:P02647", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOA1" ], "parents" : [ 264851, 349644, 5682094 ], "children" : [ ] }, { "dbId" : 174756, "stId" : "R-HSA-174756", "displayName" : "ApoB-48:TG:PL complex [endoplasmic reticulum lumen]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 11 ], "parents" : [ 174626 ], "children" : [ 174620, 174648, 174694 ] }, { "dbId" : 6789313, "stId" : "R-HSA-6789313", "displayName" : "LIPG dimer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 512 ], "parents" : [ ], "children" : [ 6789318 ] }, { "dbId" : 939176, "stId" : "R-HSA-939176", "displayName" : "Ub-63-UBC(1-76) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 1604784, "stId" : "R-ALL-1604784", "displayName" : "Heparins [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 199 ], "identifier" : "24505", "standardIdentifier" : "chebi:24505", "referenceType" : "ReferenceMolecule", "parents" : [ 6785208 ], "children" : [ ] }, { "dbId" : 174762, "stId" : "R-HSA-174762", "displayName" : "APOB(28-2179) [endosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 174799 ], "children" : [ ] }, { "dbId" : 6784718, "stId" : "R-HSA-6784718", "displayName" : "APOA4,APOA5,APOC2,CIDEC,FGF21 [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 188 ], "parents" : [ ], "children" : [ 6784664, 2395773, 2404145, 6784692, 6784693 ] }, { "dbId" : 5215972, "stId" : "R-HSA-5215972", "displayName" : "ZDHHC8 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 94 ], "identifier" : "Q9ULC8", "standardIdentifier" : "uniprot:Q9ULC8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ZDHHC8", "KIAA1292", "ZDHHCL1", "ZNF378" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 939173, "stId" : "R-HSA-939173", "displayName" : "Ub-291-UBC(229-304) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 29356, "stId" : "R-ALL-29356", "displayName" : "H2O [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 245, 118, 397 ], "identifier" : "15377", "standardIdentifier" : "chebi:15377", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 194222, "stId" : "R-HSA-194222", "displayName" : "ABCG1 dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 247 ], "parents" : [ ], "children" : [ 2975951 ] }, { "dbId" : 174766, "stId" : "R-HSA-174766", "displayName" : "APOE [endosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P02649", "standardIdentifier" : "uniprot:P02649", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOE" ], "parents" : [ 174698, 174795 ], "children" : [ ] }, { "dbId" : 939168, "stId" : "R-HSA-939168", "displayName" : "Ub-215-UBB(153-228) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 939169, "stId" : "R-HSA-939169", "displayName" : "Ub-63-UBA52(1-76) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62987", "standardIdentifier" : "uniprot:P62987", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBA52", "UBCEP2" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 174770, "stId" : "R-HSA-174770", "displayName" : "APOB(28-2179) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 174729 ], "children" : [ ] }, { "dbId" : 6784727, "stId" : "R-HSA-6784727", "displayName" : "PCSK9 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 411, 479 ], "identifier" : "Q8NBP7", "standardIdentifier" : "uniprot:Q8NBP7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PCSK9", "NARC1", "PSEC0052" ], "parents" : [ 9733426, 6784730, 8855118 ], "children" : [ ] }, { "dbId" : 939198, "stId" : "R-HSA-939198", "displayName" : "Ub-595-UBC(533-608) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 194227, "stId" : "R-HSA-194227", "displayName" : "PLTP [extracellular region]", "schemaClass" : "CandidateSet", "speciesId" : 48887, "diagramIds" : [ 274 ], "parents" : [ ], "children" : [ 194260, 194203 ] }, { "dbId" : 216752, "stId" : "R-HSA-216752", "displayName" : "discoidal HDL [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 136 ], "parents" : [ 266083, 264684 ], "children" : [ 171149, 171066, 174720 ] }, { "dbId" : 174769, "stId" : "R-HSA-174769", "displayName" : "spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 218 ], "parents" : [ ], "children" : [ 174701, 174699, 174725, 265523, 174775, 174720 ] }, { "dbId" : 174775, "stId" : "R-HSA-174775", "displayName" : "APOA2(24-100) [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P02652", "standardIdentifier" : "uniprot:P02652", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOA2" ], "parents" : [ 174769, 174798, 174697, 174791 ], "children" : [ ] }, { "dbId" : 194231, "stId" : "R-HSA-194231", "displayName" : "CETP [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P11597", "standardIdentifier" : "uniprot:P11597", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CETP" ], "parents" : [ 266351, 266340 ], "children" : [ ] }, { "dbId" : 174779, "stId" : "R-ALL-174779", "displayName" : "TAGs [endoplasmic reticulum membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 48, 2 ], "identifier" : "17855", "standardIdentifier" : "chebi:17855", "referenceType" : "ReferenceMolecule", "parents" : [ 174630 ], "children" : [ ] }, { "dbId" : 216762, "stId" : "R-ALL-216762", "displayName" : "CHOL [transport vesicle membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 401, 117, 249 ], "identifier" : "16113", "standardIdentifier" : "chebi:16113", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 9737774, "stId" : "R-ALL-9737774", "displayName" : "lomitapide [endoplasmic reticulum lumen]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "diagramIds" : [ 1011 ], "identifier" : "7439", "standardIdentifier" : "iuphar.ligand:7439", "chebiIdentifier" : "chebi:72297", "parents" : [ 9737771 ], "children" : [ ] }, { "dbId" : 29370, "stId" : "R-ALL-29370", "displayName" : "ADP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 102, 246, 120 ], "identifier" : "456216", "standardIdentifier" : "chebi:456216", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 6784733, "stId" : "R-HSA-6784733", "displayName" : "PCSK9:LDLR:Clathrin:AP2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 418 ], "parents" : [ ], "children" : [ 6784730, 177505 ] }, { "dbId" : 29372, "stId" : "R-ALL-29372", "displayName" : "Pi [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 121, 251 ], "identifier" : "43474", "standardIdentifier" : "chebi:43474", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 939186, "stId" : "R-HSA-939186", "displayName" : "Ub-215-UBC(153-228) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 194239, "stId" : "R-HSA-194239", "displayName" : "LCAT [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 259, 291 ], "identifier" : "P04180", "standardIdentifier" : "uniprot:P04180", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LCAT" ], "parents" : [ 266308, 264684 ], "children" : [ ] }, { "dbId" : 6784730, "stId" : "R-HSA-6784730", "displayName" : "PCSK9:LDLR [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 412 ], "parents" : [ 6784733 ], "children" : [ 171053, 6784727 ] }, { "dbId" : 194236, "stId" : "R-ALL-194236", "displayName" : "1-acyl LPC [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 280 ], "identifier" : "17504", "standardIdentifier" : "chebi:17504", "referenceType" : "ReferenceMolecule", "parents" : [ 264677 ], "children" : [ ] }, { "dbId" : 9737771, "stId" : "R-HSA-9737771", "displayName" : "MTTP:lomitapide [endoplasmic reticulum lumen]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 875 ], "parents" : [ ], "children" : [ 174681, 9737774 ] }, { "dbId" : 6784728, "stId" : "R-HSA-6784728", "displayName" : "PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 424 ], "parents" : [ ], "children" : [ 2130671, 6784822 ] }, { "dbId" : 216770, "stId" : "R-ALL-216770", "displayName" : "PL [transport vesicle membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 130 ], "identifier" : "16247", "standardIdentifier" : "chebi:16247", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 6785190, "stId" : "R-HSA-6785190", "displayName" : "LIPC dimer [endoplasmic reticulum lumen]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 192 ], "parents" : [ 6785173 ], "children" : [ 6785172 ] }, { "dbId" : 174787, "stId" : "R-HSA-174787", "displayName" : "chylomicron remnant:apoE complex [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 174816 ], "children" : [ 174649, 174651 ] }, { "dbId" : 939212, "stId" : "R-HSA-939212", "displayName" : "Ub-519-UBC(457-532) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 174791, "stId" : "R-HSA-174791", "displayName" : "nascent chylomicron [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 16 ], "parents" : [ ], "children" : [ 171149, 174701, 174729, 171076, 174775, 171126, 174720 ] }, { "dbId" : 174788, "stId" : "R-HSA-174788", "displayName" : "APOB(28-2179) [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 174746 ], "children" : [ ] }, { "dbId" : 939206, "stId" : "R-HSA-939206", "displayName" : "Ub-367-UBC(305-380) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 174795, "stId" : "R-HSA-174795", "displayName" : "chylomicron remnant [endosome membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 174698 ], "children" : [ 171135, 174799, 174766, 171061, 171093 ] }, { "dbId" : 8855118, "stId" : "R-HSA-8855118", "displayName" : "VLDL:PCSK9 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 477 ], "parents" : [ 8855134 ], "children" : [ 6784727, 5216079 ] }, { "dbId" : 375500, "stId" : "R-HSA-375500", "displayName" : "NR1H2 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P55055", "standardIdentifier" : "uniprot:P55055", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NR1H2", "LXRB", "NER", "UNR" ], "parents" : [ 8854954 ], "children" : [ ] }, { "dbId" : 174792, "stId" : "R-HSA-174792", "displayName" : "chylomicron remnant:apoE complex [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 221 ], "parents" : [ ], "children" : [ 174807, 174646 ] }, { "dbId" : 8856140, "stId" : "R-HSA-8856140", "displayName" : "APOBR dimer:VLDL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 324 ], "parents" : [ ], "children" : [ 8855875, 8854406 ] }, { "dbId" : 174798, "stId" : "R-HSA-174798", "displayName" : "TG-depleted chylomicron [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 209 ], "parents" : [ ], "children" : [ 171149, 174701, 174729, 174699, 174725, 171076, 174775, 174646, 171126, 174720 ] }, { "dbId" : 6784682, "stId" : "R-HSA-6784682", "displayName" : "PCSK5 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 171 ], "identifier" : "Q92824", "standardIdentifier" : "uniprot:Q92824", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PCSK5", "PC5", "PC6" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 174799, "stId" : "R-HSA-174799", "displayName" : "ApoB-48:TG:PL complex [endosome membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 174795 ], "children" : [ 171148, 174762, 171093 ] }, { "dbId" : 174797, "stId" : "R-HSA-174797", "displayName" : "chylomicron remnant [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 174659 ], "children" : [ 174666, 171076, 171095, 174615, 171057 ] }, { "dbId" : 2130671, "stId" : "R-HSA-2130671", "displayName" : "Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 427 ], "parents" : [ 6784728, 8855135 ], "children" : [ 2130637, 2130407 ] }, { "dbId" : 6784695, "stId" : "R-HSA-6784695", "displayName" : "APOA4 gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "ENSG00000110244", "standardIdentifier" : "ensembl:ENSG00000110244", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "APOA4" ], "parents" : [ 6784668 ], "children" : [ ] }, { "dbId" : 6784693, "stId" : "R-HSA-6784693", "displayName" : "CIDEC [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q96AQ7-1", "standardIdentifier" : "uniprot:Q96AQ7-1", "referenceType" : "ReferenceIsoform", "geneNames" : [ "CIDEC", "FSP27" ], "parents" : [ 6784718 ], "children" : [ ] }, { "dbId" : 158417, "stId" : "R-ALL-158417", "displayName" : "Zn2+ [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "29105", "standardIdentifier" : "chebi:29105", "referenceType" : "ReferenceMolecule", "parents" : [ 264759 ], "children" : [ ] }, { "dbId" : 6784692, "stId" : "R-HSA-6784692", "displayName" : "FGF21 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q9NSA1", "standardIdentifier" : "uniprot:Q9NSA1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "FGF21", "UNQ3115/PRO10196" ], "parents" : [ 6784718 ], "children" : [ ] }, { "dbId" : 174807, "stId" : "R-HSA-174807", "displayName" : "chylomicron remnant [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 217 ], "parents" : [ 174792 ], "children" : [ 171149, 174729, 171076, 174646, 171126 ] }, { "dbId" : 194260, "stId" : "R-HSA-194260", "displayName" : "PLTP-1 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P55058-1", "standardIdentifier" : "uniprot:P55058-1", "referenceType" : "ReferenceIsoform", "geneNames" : [ "PLTP" ], "parents" : [ 194227 ], "children" : [ ] }, { "dbId" : 174804, "stId" : "R-HSA-174804", "displayName" : "APOE [endosome lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P02649", "standardIdentifier" : "uniprot:P02649", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOE" ], "parents" : [ 174805, 174594 ], "children" : [ ] }, { "dbId" : 939224, "stId" : "R-HSA-939224", "displayName" : "Ub-63-UBB(1-76) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 174805, "stId" : "R-HSA-174805", "displayName" : "chylomicron remnant [endosome lumen]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 174594 ], "children" : [ 171144, 171083, 174804, 174593, 171123 ] }, { "dbId" : 349405, "stId" : "R-ALL-349405", "displayName" : "torcetrapib [extracellular region]", "schemaClass" : "ChemicalDrug", "speciesId" : 0, "diagramIds" : [ 1003 ], "identifier" : "159325", "standardIdentifier" : "pubchem.compound:159325", "chebiIdentifier" : "chebi:49203", "parents" : [ 349410 ], "children" : [ ] }, { "dbId" : 8855135, "stId" : "R-HSA-8855135", "displayName" : "VLDL:PCSK9:Clathrin:AP2 [lysosomal membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 487 ], "parents" : [ ], "children" : [ 2130671, 8855132 ] }, { "dbId" : 8855134, "stId" : "R-HSA-8855134", "displayName" : "VLDL:PCSK9:Clathrin:AP2 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 482 ], "parents" : [ ], "children" : [ 8855118, 177505 ] }, { "dbId" : 8855132, "stId" : "R-HSA-8855132", "displayName" : "VLDL:PCSK9 [lysosomal membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 8855135 ], "children" : [ 8855128, 8855141 ] }, { "dbId" : 109276, "stId" : "R-ALL-109276", "displayName" : "H2O [extracellular region]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 521, 203 ], "identifier" : "15377", "standardIdentifier" : "chebi:15377", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 8855129, "stId" : "R-HSA-8855129", "displayName" : "MYLIP dimer [cytosol]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 467 ], "parents" : [ ], "children" : [ 8850908 ] }, { "dbId" : 6785208, "stId" : "R-HSA-6785208", "displayName" : "LIPC dimer:heparin [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 200 ], "parents" : [ ], "children" : [ 6785179, 1604784 ] }, { "dbId" : 8855128, "stId" : "R-HSA-8855128", "displayName" : "PCSK9 [lysosomal membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q8NBP7", "standardIdentifier" : "uniprot:Q8NBP7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PCSK9", "NARC1", "PSEC0052" ], "parents" : [ 8855132 ], "children" : [ ] }, { "dbId" : 176866, "stId" : "R-HSA-176866", "displayName" : "Lp(a) [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 236 ], "parents" : [ ], "children" : [ 176877, 171131 ] }, { "dbId" : 2975951, "stId" : "R-HSA-2975951", "displayName" : "ABCG1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P45844", "standardIdentifier" : "uniprot:P45844", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ABCG1", "ABC8", "WHT1" ], "parents" : [ 194222 ], "children" : [ ] }, { "dbId" : 174816, "stId" : "R-HSA-174816", "displayName" : "chylomicron remnant:apoE:LDLR complex [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 310 ], "parents" : [ ], "children" : [ 171105, 174787 ] }, { "dbId" : 349415, "stId" : "R-HSA-349415", "displayName" : "SCARB1-2 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 438 ], "identifier" : "Q8WTV0-2", "standardIdentifier" : "uniprot:Q8WTV0-2", "referenceType" : "ReferenceIsoform", "geneNames" : [ "SCARB1", "CD36L1", "CLA1" ], "parents" : [ 349649 ], "children" : [ ] }, { "dbId" : 8855141, "stId" : "R-HSA-8855141", "displayName" : "VLDLR [lysosomal membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P98155", "standardIdentifier" : "uniprot:P98155", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "VLDLR" ], "parents" : [ 8855132 ], "children" : [ ] }, { "dbId" : 349410, "stId" : "R-HSA-349410", "displayName" : "CETP:spherical HDL:torcetrapib complex [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 1004 ], "parents" : [ ], "children" : [ 266351, 349405, 265523 ] }, { "dbId" : 939241, "stId" : "R-HSA-939241", "displayName" : "Ub-671-UBC(609-684) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 8855136, "stId" : "R-HSA-8855136", "displayName" : "Ub-K839-VLDLR [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 466 ], "identifier" : "P98155", "standardIdentifier" : "uniprot:P98155", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "VLDLR" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 6784654, "stId" : "R-HSA-6784654", "displayName" : "CREB3L3(1-?) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 176 ], "identifier" : "Q68CJ9", "standardIdentifier" : "uniprot:Q68CJ9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CREB3L3", "CREBH", "HYST1481" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 939235, "stId" : "R-HSA-939235", "displayName" : "Ub-139-UBB(77-152) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG47", "standardIdentifier" : "uniprot:P0CG47", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBB" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 2130637, "stId" : "R-HSA-2130637", "displayName" : "Adaptor protein 2 complex [endolysosome membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 2130671 ], "children" : [ 6784826, 6784827, 6784828, 6784821 ] }, { "dbId" : 176877, "stId" : "R-HSA-176877", "displayName" : "LPA [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 235 ], "identifier" : "P08519", "standardIdentifier" : "uniprot:P08519", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LPA" ], "parents" : [ 176866 ], "children" : [ ] }, { "dbId" : 6785173, "stId" : "R-HSA-6785173", "displayName" : "LIPC dimer:LMF1,2 [endoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 193 ], "parents" : [ ], "children" : [ 6785148, 6785190 ] }, { "dbId" : 6785172, "stId" : "R-HSA-6785172", "displayName" : "LIPC [endoplasmic reticulum lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P11150", "standardIdentifier" : "uniprot:P11150", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LIPC", "HTGL" ], "parents" : [ 6785190 ], "children" : [ ] }, { "dbId" : 5215930, "stId" : "R-HSA-5215930", "displayName" : "APOC4 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 69 ], "identifier" : "P55056", "standardIdentifier" : "uniprot:P55056", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOC4" ], "parents" : [ 8855875 ], "children" : [ ] }, { "dbId" : 939254, "stId" : "R-HSA-939254", "displayName" : "Ub-139-UBC(77-152) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P0CG48", "standardIdentifier" : "uniprot:P0CG48", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "UBC" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 6784670, "stId" : "R-HSA-6784670", "displayName" : "APOC2 gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "ENSG00000234906", "standardIdentifier" : "ensembl:ENSG00000234906", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "APOC2", "APC2" ], "parents" : [ 6784668 ], "children" : [ ] }, { "dbId" : 163579, "stId" : "R-ALL-163579", "displayName" : "CHEST [lipid droplet]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 393 ], "identifier" : "17002", "standardIdentifier" : "chebi:17002", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 6784669, "stId" : "R-HSA-6784669", "displayName" : "CREB3L3 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 174 ], "identifier" : "Q68CJ9", "standardIdentifier" : "uniprot:Q68CJ9", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CREB3L3", "CREBH", "HYST1481" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 6784668, "stId" : "R-HSA-6784668", "displayName" : "APOA4,APOA5,APOC2,CIDEC,FGF21 genes [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 187 ], "parents" : [ ], "children" : [ 6784665, 6784670, 6784626, 5649925, 6784695 ] }, { "dbId" : 6785179, "stId" : "R-HSA-6785179", "displayName" : "LIPC dimer [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 196 ], "parents" : [ 6785208 ], "children" : [ 5694065 ] }, { "dbId" : 6784665, "stId" : "R-HSA-6784665", "displayName" : "CIDEC gene [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "ENSG00000187288", "standardIdentifier" : "ensembl:ENSG00000187288", "referenceType" : "ReferenceDNASequence", "geneNames" : [ "CIDEC", "FSP27" ], "parents" : [ 6784668 ], "children" : [ ] }, { "dbId" : 939248, "stId" : "R-HSA-939248", "displayName" : "Ub-63-RPS27A(1-76) [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P62979", "standardIdentifier" : "uniprot:P62979", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "RPS27A", "UBA80", "UBCEP1" ], "parents" : [ 450143 ], "children" : [ ] }, { "dbId" : 6784664, "stId" : "R-HSA-6784664", "displayName" : "APOA5 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q6Q788", "standardIdentifier" : "uniprot:Q6Q788", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOA5", "RAP3", "UNQ411/PRO773" ], "parents" : [ 6784718 ], "children" : [ ] }, { "dbId" : 6784871, "stId" : "R-HSA-6784871", "displayName" : "pre-VLDL [endoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 42 ], "parents" : [ ], "children" : [ 174671, 6784882, 1500594 ] }, { "dbId" : 5216079, "stId" : "R-HSA-5216079", "displayName" : "VLDLR [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 320, 470 ], "identifier" : "P98155", "standardIdentifier" : "uniprot:P98155", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "VLDLR" ], "parents" : [ 8855118, 8854464 ], "children" : [ ] }, { "dbId" : 8854406, "stId" : "R-HSA-8854406", "displayName" : "APOBR dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 323 ], "parents" : [ 8856140 ], "children" : [ 8854404 ] }, { "dbId" : 8854404, "stId" : "R-HSA-8854404", "displayName" : "APOBR [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q0VD83", "standardIdentifier" : "uniprot:Q0VD83", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOBR", "APOB48R" ], "parents" : [ 8854406 ], "children" : [ ] }, { "dbId" : 389382, "stId" : "R-HSA-389382", "displayName" : "AP2S1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P53680", "standardIdentifier" : "uniprot:P53680", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AP2S1", "AP17", "CLAPS2" ], "parents" : [ 177480 ], "children" : [ ] }, { "dbId" : 1678620, "stId" : "R-ALL-1678620", "displayName" : "HSPG [plasma membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 154 ], "identifier" : "24499", "standardIdentifier" : "chebi:24499", "referenceType" : "ReferenceMolecule", "parents" : [ 8867477 ], "children" : [ ] }, { "dbId" : 8865666, "stId" : "R-ALL-8865666", "displayName" : "FA [lysosomal lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 364 ], "identifier" : "35366", "standardIdentifier" : "chebi:35366", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 167690, "stId" : "R-HSA-167690", "displayName" : "AP2B1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P63010", "standardIdentifier" : "uniprot:P63010", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AP2B1", "ADTB2", "CLAPB1" ], "parents" : [ 177480 ], "children" : [ ] }, { "dbId" : 5216067, "stId" : "R-HSA-5216067", "displayName" : "GPIHBP1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 157 ], "identifier" : "Q8IV16", "standardIdentifier" : "uniprot:Q8IV16", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "GPIHBP1", "HBP1" ], "parents" : [ 8857969 ], "children" : [ ] }, { "dbId" : 8933252, "stId" : "R-HSA-8933252", "displayName" : "LSR trimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 336, 327 ], "parents" : [ 8933254, 8933291 ], "children" : [ 8933138 ] }, { "dbId" : 8933254, "stId" : "R-HSA-8933254", "displayName" : "LSR trimer:LDL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 335 ], "parents" : [ ], "children" : [ 8933252, 171131 ] }, { "dbId" : 2980668, "stId" : "R-HSA-2980668", "displayName" : "CLTC [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q00610", "standardIdentifier" : "uniprot:Q00610", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CLTC", "CLH17", "CLTCL2", "KIAA0034" ], "parents" : [ 177482 ], "children" : [ ] }, { "dbId" : 6784882, "stId" : "R-HSA-6784882", "displayName" : "APOB(28-4563) [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 41 ], "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 6784871 ], "children" : [ ] }, { "dbId" : 5216090, "stId" : "R-HSA-5216090", "displayName" : "APOF [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 232 ], "identifier" : "Q13790", "standardIdentifier" : "uniprot:Q13790", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOF" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 2404145, "stId" : "R-HSA-2404145", "displayName" : "APOC2 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P02655", "standardIdentifier" : "uniprot:P02655", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOC2", "APC2" ], "parents" : [ 6784718 ], "children" : [ ] }, { "dbId" : 200993, "stId" : "R-ALL-200993", "displayName" : "PALM-CoA [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 91 ], "identifier" : "57379", "standardIdentifier" : "chebi:57379", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 8933291, "stId" : "R-HSA-8933291", "displayName" : "LSR trimer:VLDL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 328 ], "parents" : [ ], "children" : [ 8933252, 8855875 ] }, { "dbId" : 6788929, "stId" : "R-HSA-6788929", "displayName" : "LIPA [lysosomal lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 366 ], "identifier" : "P38571", "standardIdentifier" : "uniprot:P38571", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LIPA" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 6784846, "stId" : "R-HSA-6784846", "displayName" : "ANGPTL3:ANGPTL8 [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 163 ], "parents" : [ ], "children" : [ 6784850, 6784898 ] }, { "dbId" : 8854957, "stId" : "R-HSA-8854957", "displayName" : "NR1H3 [nucleoplasm]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q13133", "standardIdentifier" : "uniprot:Q13133", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NR1H3", "LXRA" ], "parents" : [ 8854954 ], "children" : [ ] }, { "dbId" : 8876460, "stId" : "R-HSA-8876460", "displayName" : "NPC2:CHOL [lysosomal lumen]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 371 ], "parents" : [ ], "children" : [ 8876488, 8848047 ] }, { "dbId" : 8870827, "stId" : "R-HSA-8870827", "displayName" : "CLTC [endolysosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q00610", "standardIdentifier" : "uniprot:Q00610", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CLTC", "CLH17", "CLTCL2", "KIAA0034" ], "parents" : [ 2130407 ], "children" : [ ] }, { "dbId" : 8858026, "stId" : "R-HSA-8858026", "displayName" : "HDLBP [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 433 ], "identifier" : "Q00341", "standardIdentifier" : "uniprot:Q00341", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "HDLBP", "HBP", "VGL" ], "parents" : [ 8858255 ], "children" : [ ] }, { "dbId" : 8854954, "stId" : "R-HSA-8854954", "displayName" : "NR1H2,NR1H3 [nucleoplasm]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 468 ], "parents" : [ ], "children" : [ 8854957, 375500 ] }, { "dbId" : 2980611, "stId" : "R-HSA-2980611", "displayName" : "CLTA [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P09496", "standardIdentifier" : "uniprot:P09496", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CLTA" ], "parents" : [ 177482 ], "children" : [ ] }, { "dbId" : 8870825, "stId" : "R-HSA-8870825", "displayName" : "CLTA [endolysosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P09496", "standardIdentifier" : "uniprot:P09496", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CLTA" ], "parents" : [ 2130407 ], "children" : [ ] }, { "dbId" : 111920, "stId" : "R-HSA-111920", "displayName" : "PKA catalytic subunit [cytosol]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "diagramIds" : [ 104 ], "parents" : [ ], "children" : [ 57848, 57846, 57844 ] }, { "dbId" : 6784850, "stId" : "R-HSA-6784850", "displayName" : "ANGPTL8 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 162 ], "identifier" : "Q6UXH0", "standardIdentifier" : "uniprot:Q6UXH0", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ANGPTL8", "C19orf80", "RIFL", "UNQ599/PRO1185" ], "parents" : [ 6784846 ], "children" : [ ] }, { "dbId" : 265523, "stId" : "R-HSA-265523", "displayName" : "spherical HDL [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 19, 436, 265, 441 ], "parents" : [ 8858255, 174769, 349410, 266308, 266348, 174643 ], "children" : [ 171149, 171066, 171076, 171126, 174720 ] }, { "dbId" : 8876478, "stId" : "R-ALL-8876478", "displayName" : "CHOL [lysosomal membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "16113", "standardIdentifier" : "chebi:16113", "referenceType" : "ReferenceMolecule", "parents" : [ 8876475 ], "children" : [ ] }, { "dbId" : 8876475, "stId" : "R-HSA-8876475", "displayName" : "NPC1:CHOL [lysosomal membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 374 ], "parents" : [ ], "children" : [ 8876478, 5216153 ] }, { "dbId" : 8854464, "stId" : "R-HSA-8854464", "displayName" : "VLDL:VLDLR [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 321 ], "parents" : [ ], "children" : [ 8855875, 5216079 ] }, { "dbId" : 177482, "stId" : "R-HSA-177482", "displayName" : "Clathrin [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 177505 ], "children" : [ 2980611, 2980668 ] }, { "dbId" : 177480, "stId" : "R-HSA-177480", "displayName" : "AP-2 complex [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 177505 ], "children" : [ 167690, 389382, 167585, 444999 ] }, { "dbId" : 8876492, "stId" : "R-HSA-8876492", "displayName" : "SOAT2 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O75908", "standardIdentifier" : "uniprot:O75908", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SOAT2", "ACACT2", "ACAT2" ], "parents" : [ 8876694 ], "children" : [ ] }, { "dbId" : 8876490, "stId" : "R-HSA-8876490", "displayName" : "SOAT1 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P35610", "standardIdentifier" : "uniprot:P35610", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "SOAT1", "ACACT", "ACACT1", "ACAT", "ACAT1", "SOAT", "STAT" ], "parents" : [ 8876694 ], "children" : [ ] }, { "dbId" : 8876488, "stId" : "R-HSA-8876488", "displayName" : "NPC2 [lysosomal lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 370 ], "identifier" : "P61916", "standardIdentifier" : "uniprot:P61916", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NPC2", "HE1" ], "parents" : [ 8876460 ], "children" : [ ] }, { "dbId" : 6784823, "stId" : "R-HSA-6784823", "displayName" : "PCSK9 [endolysosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q8NBP7", "standardIdentifier" : "uniprot:Q8NBP7", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PCSK9", "NARC1", "PSEC0052" ], "parents" : [ 6784822 ], "children" : [ ] }, { "dbId" : 6784822, "stId" : "R-HSA-6784822", "displayName" : "PCSK9:LDLR [endolysosome membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 6784728 ], "children" : [ 6784818, 6784823 ] }, { "dbId" : 6784821, "stId" : "R-HSA-6784821", "displayName" : "AP2S1 [endolysosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P53680", "standardIdentifier" : "uniprot:P53680", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AP2S1", "AP17", "CLAPS2" ], "parents" : [ 2130637 ], "children" : [ ] }, { "dbId" : 177494, "stId" : "R-HSA-177494", "displayName" : "AP2A1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O95782", "standardIdentifier" : "uniprot:O95782", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AP2A1", "ADTAA", "CLAPA1" ], "parents" : [ 444999 ], "children" : [ ] }, { "dbId" : 6784819, "stId" : "R-HSA-6784819", "displayName" : "AP2A2(1-939) [endolysosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O94973", "standardIdentifier" : "uniprot:O94973", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AP2A2", "ADTAB", "CLAPA2", "HIP9", "HYPJ", "KIAA0899" ], "parents" : [ 6784826 ], "children" : [ ] }, { "dbId" : 6784818, "stId" : "R-HSA-6784818", "displayName" : "LDLR [endolysosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P01130", "standardIdentifier" : "uniprot:P01130", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LDLR" ], "parents" : [ 6784822 ], "children" : [ ] }, { "dbId" : 6784829, "stId" : "R-HSA-6784829", "displayName" : "AP2A1 [endolysosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O95782", "standardIdentifier" : "uniprot:O95782", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AP2A1", "ADTAA", "CLAPA1" ], "parents" : [ 6784826 ], "children" : [ ] }, { "dbId" : 8850908, "stId" : "R-HSA-8850908", "displayName" : "MYLIP [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q8WY64", "standardIdentifier" : "uniprot:Q8WY64", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "MYLIP", "BZF1", "IDOL", "BM-023", "PP5242" ], "parents" : [ 8855129 ], "children" : [ ] }, { "dbId" : 6784828, "stId" : "R-HSA-6784828", "displayName" : "AP2M1 [endolysosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q96CW1", "standardIdentifier" : "uniprot:Q96CW1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AP2M1", "CLAPM1", "KIAA0109" ], "parents" : [ 2130637 ], "children" : [ ] }, { "dbId" : 177502, "stId" : "R-HSA-177502", "displayName" : "AP2A2(1-939) [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O94973", "standardIdentifier" : "uniprot:O94973", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AP2A2", "ADTAB", "CLAPA2", "HIP9", "HYPJ", "KIAA0899" ], "parents" : [ 444999 ], "children" : [ ] }, { "dbId" : 6784827, "stId" : "R-HSA-6784827", "displayName" : "AP2B1 [endolysosome membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P63010", "standardIdentifier" : "uniprot:P63010", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "AP2B1", "ADTB2", "CLAPB1" ], "parents" : [ 2130637 ], "children" : [ ] }, { "dbId" : 6784826, "stId" : "R-HSA-6784826", "displayName" : "Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane]", "schemaClass" : "DefinedSet", "speciesId" : 48887, "parents" : [ 2130637 ], "children" : [ 6784829, 6784819 ] }, { "dbId" : 177505, "stId" : "R-HSA-177505", "displayName" : "Clathrin:AP-2 complex [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 417, 484 ], "parents" : [ 6784733, 8855134 ], "children" : [ 177480, 177482 ] }, { "dbId" : 266083, "stId" : "R-HSA-266083", "displayName" : "discoidal HDL:cholesterol [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 256 ], "parents" : [ ], "children" : [ 171149, 216752 ] }, { "dbId" : 8937441, "stId" : "R-HSA-8937441", "displayName" : "CES3 [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 404 ], "identifier" : "Q6UWW8", "standardIdentifier" : "uniprot:Q6UWW8", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "CES3", "UNQ869/PRO1887" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 193384, "stId" : "R-ALL-193384", "displayName" : "CHOL [endoplasmic reticulum membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 378 ], "identifier" : "16113", "standardIdentifier" : "chebi:16113", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 8855541, "stId" : "R-HSA-8855541", "displayName" : "APOC1 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 70 ], "identifier" : "P02654", "standardIdentifier" : "uniprot:P02654", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOC1" ], "parents" : [ 8855875 ], "children" : [ ] }, { "dbId" : 9733405, "stId" : "R-ALL-9733405", "displayName" : "PCSK9 inhibitors [extracellular region]", "schemaClass" : "DefinedSet", "speciesId" : 0, "diagramIds" : [ 596 ], "parents" : [ 9733426 ], "children" : [ 9733378, 9733413 ] }, { "dbId" : 6813685, "stId" : "R-HSA-6813685", "displayName" : "NCEH1 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 399 ], "identifier" : "Q6PIU2", "standardIdentifier" : "uniprot:Q6PIU2", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NCEH1", "AADACL1", "KIAA1363" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 9733378, "stId" : "R-ALL-9733378", "displayName" : "alirocumab [extracellular region]", "schemaClass" : "ProteinDrug", "speciesId" : 0, "identifier" : "6744", "standardIdentifier" : "iuphar.ligand:6744", "parents" : [ 9733405 ], "children" : [ ] }, { "dbId" : 8933138, "stId" : "R-HSA-8933138", "displayName" : "LSR [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "Q86X29", "standardIdentifier" : "uniprot:Q86X29", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "LSR", "ILDR3", "LISCH" ], "parents" : [ 8933252 ], "children" : [ ] }, { "dbId" : 76194, "stId" : "R-ALL-76194", "displayName" : "CoA-SH [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 388, 92 ], "identifier" : "57287", "standardIdentifier" : "chebi:57287", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 1500594, "stId" : "R-ALL-1500594", "displayName" : "TAG [endoplasmic reticulum membrane]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "17855", "standardIdentifier" : "chebi:17855", "referenceType" : "ReferenceMolecule", "parents" : [ 6784871 ], "children" : [ ] }, { "dbId" : 9733426, "stId" : "R-HSA-9733426", "displayName" : "PCSK9:PCSK9 inhibitors [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 597 ], "parents" : [ ], "children" : [ 9733405, 6784727 ] }, { "dbId" : 9733413, "stId" : "R-ALL-9733413", "displayName" : "evolocumab [extracellular region]", "schemaClass" : "ProteinDrug", "speciesId" : 0, "identifier" : "7343", "standardIdentifier" : "iuphar.ligand:7343", "parents" : [ 9733405 ], "children" : [ ] }, { "dbId" : 1500578, "stId" : "R-ALL-1500578", "displayName" : "acyl-CoA [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 384 ], "identifier" : "58342", "standardIdentifier" : "chebi:58342", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 113592, "stId" : "R-ALL-113592", "displayName" : "ATP [cytosol]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "diagramIds" : [ 244, 101, 119 ], "identifier" : "30616", "standardIdentifier" : "chebi:30616", "referenceType" : "ReferenceMolecule", "parents" : [ ], "children" : [ ] }, { "dbId" : 1181103, "stId" : "R-HSA-1181103", "displayName" : "FURIN [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P09958", "standardIdentifier" : "uniprot:P09958", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "FURIN", "FUR", "PACE", "PCSK3" ], "parents" : [ 6784618 ], "children" : [ ] }, { "dbId" : 5682069, "stId" : "R-HSA-5682069", "displayName" : "4xPALM-C-p-2S-ABCA1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O95477", "standardIdentifier" : "uniprot:O95477", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ABCA1", "ABC1", "CERP" ], "parents" : [ 5682107 ], "children" : [ ] }, { "dbId" : 8855875, "stId" : "R-HSA-8855875", "displayName" : "VLDL [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 71 ], "parents" : [ 8856140, 8854464, 8933291 ], "children" : [ 5215930, 8866325, 8855541 ] }, { "dbId" : 5682067, "stId" : "R-HSA-5682067", "displayName" : "4xPALM-C-ABCA1 tetramer [endoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 93 ], "parents" : [ ], "children" : [ 5682085 ] }, { "dbId" : 2130407, "stId" : "R-HSA-2130407", "displayName" : "Clathrin [clathrin-coated endocytic vesicle membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 2130671 ], "children" : [ 8870825, 8870827 ] }, { "dbId" : 349645, "stId" : "R-HSA-349645", "displayName" : "pre-beta HDL [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 147, 509 ], "parents" : [ ], "children" : [ 171149, 171066, 171076, 174720 ] }, { "dbId" : 8876367, "stId" : "R-HSA-8876367", "displayName" : "LDL [lysosomal lumen]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 359 ], "parents" : [ ], "children" : [ 8848047, 8876368, 8876369, 8876370, 8876371 ] }, { "dbId" : 349644, "stId" : "R-HSA-349644", "displayName" : "spherical HDL [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "parents" : [ 349649 ], "children" : [ 171095, 216742, 171142, 171057, 171075 ] }, { "dbId" : 8876365, "stId" : "R-HSA-8876365", "displayName" : "LIPA-degraded LDL [lysosomal lumen]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 363 ], "parents" : [ ], "children" : [ 8848047, 8876369, 8876370, 8876371 ] }, { "dbId" : 5682073, "stId" : "R-HSA-5682073", "displayName" : "4xPALM-C-ABCA1 tetramer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 96 ], "parents" : [ ], "children" : [ 5682091 ] }, { "dbId" : 349649, "stId" : "R-HSA-349649", "displayName" : "spherical HDL:SR-BI complex [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 439 ], "parents" : [ ], "children" : [ 349644, 349415 ] }, { "dbId" : 8876371, "stId" : "R-ALL-8876371", "displayName" : "TAGs [lysosomal lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "17855", "standardIdentifier" : "chebi:17855", "referenceType" : "ReferenceMolecule", "parents" : [ 8876365, 8876367 ], "children" : [ ] }, { "dbId" : 8876370, "stId" : "R-ALL-8876370", "displayName" : "PL [lysosomal lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "16247", "standardIdentifier" : "chebi:16247", "referenceType" : "ReferenceMolecule", "parents" : [ 8876365, 8876367 ], "children" : [ ] }, { "dbId" : 5216153, "stId" : "R-HSA-5216153", "displayName" : "NPC1 [lysosomal membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 373 ], "identifier" : "O15118", "standardIdentifier" : "uniprot:O15118", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "NPC1" ], "parents" : [ 8876475 ], "children" : [ ] }, { "dbId" : 8876369, "stId" : "R-HSA-8876369", "displayName" : "APOB(28-4563) [lysosomal lumen]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P04114", "standardIdentifier" : "uniprot:P04114", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "APOB" ], "parents" : [ 8876365, 8876367 ], "children" : [ ] }, { "dbId" : 8876368, "stId" : "R-ALL-8876368", "displayName" : "cholesterol esters [lysosomal lumen]", "schemaClass" : "SimpleEntity", "speciesId" : 0, "identifier" : "17002", "standardIdentifier" : "chebi:17002", "referenceType" : "ReferenceMolecule", "parents" : [ 8876367 ], "children" : [ ] }, { "dbId" : 264677, "stId" : "R-HSA-264677", "displayName" : "albumin:2-lysophosphatidylcholine complex [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 288 ], "parents" : [ ], "children" : [ 194236, 194115 ] }, { "dbId" : 6784898, "stId" : "R-HSA-6784898", "displayName" : "ANGPTL3 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 161 ], "identifier" : "Q9Y5C1", "standardIdentifier" : "uniprot:Q9Y5C1", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ANGPTL3", "ANGPT5", "UNQ153/PRO179" ], "parents" : [ 6784846 ], "children" : [ ] }, { "dbId" : 6784897, "stId" : "R-HSA-6784897", "displayName" : "ANGPTL4 [extracellular region]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "diagramIds" : [ 168 ], "identifier" : "Q9BY76", "standardIdentifier" : "uniprot:Q9BY76", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ANGPTL4", "ARP4", "HFARP", "PGAR", "PP1158", "PSEC0166", "UNQ171/PRO197" ], "parents" : [ ], "children" : [ ] }, { "dbId" : 264684, "stId" : "R-HSA-264684", "displayName" : "LCAT:discoidal HDL complex [extracellular region]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 260 ], "parents" : [ ], "children" : [ 194239, 216752 ] }, { "dbId" : 5682107, "stId" : "R-HSA-5682107", "displayName" : "4xPALM-C-p-2S-ABCA1 tetramer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 103 ], "parents" : [ 5682094 ], "children" : [ 5682069 ] }, { "dbId" : 5682105, "stId" : "R-HSA-5682105", "displayName" : "ABCA1 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O95477", "standardIdentifier" : "uniprot:O95477", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ABCA1", "ABC1", "CERP" ], "parents" : [ 5682087 ], "children" : [ ] }, { "dbId" : 5682087, "stId" : "R-HSA-5682087", "displayName" : "ABCA1 tetramer [endoplasmic reticulum membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 90 ], "parents" : [ ], "children" : [ 5682105 ] }, { "dbId" : 5682085, "stId" : "R-HSA-5682085", "displayName" : "4xPALM-C-ABCA1 [endoplasmic reticulum membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O95477", "standardIdentifier" : "uniprot:O95477", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ABCA1", "ABC1", "CERP" ], "parents" : [ 5682067 ], "children" : [ ] }, { "dbId" : 57844, "stId" : "R-HSA-57844", "displayName" : "PRKACA [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P17612", "standardIdentifier" : "uniprot:P17612", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PRKACA", "PKACA" ], "parents" : [ 111920 ], "children" : [ ] }, { "dbId" : 57846, "stId" : "R-HSA-57846", "displayName" : "PRKACB [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P22694", "standardIdentifier" : "uniprot:P22694", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PRKACB" ], "parents" : [ 111920 ], "children" : [ ] }, { "dbId" : 8857969, "stId" : "R-HSA-8857969", "displayName" : "GPIHBP1:HSPG:LPL dimer [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 158 ], "parents" : [ ], "children" : [ 5216067, 8867477 ] }, { "dbId" : 5682094, "stId" : "R-HSA-5682094", "displayName" : "4xPALM-C-p-2S-ABCA1 tetramer:APOA1 [plasma membrane]", "schemaClass" : "Complex", "speciesId" : 48887, "diagramIds" : [ 109 ], "parents" : [ ], "children" : [ 5682107, 216742 ] }, { "dbId" : 57848, "stId" : "R-HSA-57848", "displayName" : "PRKACG [cytosol]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "P22612", "standardIdentifier" : "uniprot:P22612", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "PRKACG" ], "parents" : [ 111920 ], "children" : [ ] }, { "dbId" : 5682091, "stId" : "R-HSA-5682091", "displayName" : "4xPALM-C-ABCA1 [plasma membrane]", "schemaClass" : "EntityWithAccessionedSequence", "speciesId" : 48887, "identifier" : "O95477", "standardIdentifier" : "uniprot:O95477", "referenceType" : "ReferenceGeneProduct", "geneNames" : [ "ABCA1", "ABC1", "CERP" ], "parents" : [ 5682073 ], "children" : [ ] } ], "edges" : [ { "dbId" : 8933258, "stId" : "R-HSA-8933258", "displayName" : "LSR trimer binds LDL", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8933252, 171131 ], "outputs" : [ 8933254 ], "efs" : [ ], "diagramIds" : [ 334 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8866308, "stId" : "R-HSA-8866308", "displayName" : "pre-VLDL translocates from RER membrane to SER lumen", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8866329 ], "following" : [ 8866304 ], "inputs" : [ 6784871 ], "outputs" : [ 8866311 ], "efs" : [ ], "diagramIds" : [ 55 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8865667, "stId" : "R-HSA-8865667", "displayName" : "LIPA hydrolyses sterol esters to sterols and fatty acids", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8876366 ], "following" : [ 8876472 ], "inputs" : [ 1605715, 8876367 ], "outputs" : [ 8876365, 8848047, 8865666 ], "catalysts" : [ 6788929 ], "efs" : [ ], "diagramIds" : [ 361 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6784738, "stId" : "R-HSA-6784738", "displayName" : "Degradation of PCSK9:LDLR:Clathrin-coated vesicle", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 6784729 ], "inputs" : [ 6784728 ], "outputs" : [ 2130671 ], "efs" : [ ], "diagramIds" : [ 426 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 264834, "stId" : "R-HSA-264834", "displayName" : "Endocytosis and degradation of apoA-I", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 264848 ], "inputs" : [ 264851 ], "efs" : [ ], "diagramIds" : [ 458 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8866304, "stId" : "R-HSA-8866304", "displayName" : "pre-VLDL binds lipids to form VLDL", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8866308 ], "following" : [ 8866327 ], "inputs" : [ 8866316, 8866305, 8866307, 8866324, 8866311 ], "outputs" : [ 8866319 ], "efs" : [ ], "diagramIds" : [ 57 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 171141, "stId" : "R-HSA-171141", "displayName" : "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 171122 ], "following" : [ 171059 ], "inputs" : [ 171100 ], "outputs" : [ 171108 ], "efs" : [ ], "requirements" : [ 171143 ], "diagramIds" : [ 346 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 174731, "stId" : "R-HSA-174731", "displayName" : "Degradation of newly synthesized ApoB-48", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "inputs" : [ 174620 ], "efs" : [ ], "diagramIds" : [ 22 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6784622, "stId" : "R-HSA-6784622", "displayName" : "APOA4,APOA5,APOC2,CIDEC,FGF21 genes express APOA4,APOA5,APOC2,CIDEC,FGF21 proteins", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 6784648 ], "inputs" : [ 6784668 ], "outputs" : [ 6784718 ], "efs" : [ ], "activators" : [ 6784629 ], "diagramIds" : [ 186 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6784620, "stId" : "R-HSA-6784620", "displayName" : "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 6784648 ], "inputs" : [ 6784669 ], "outputs" : [ 6784654, 6784710 ], "catalysts" : [ 6784711 ], "efs" : [ ], "diagramIds" : [ 173 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8858252, "stId" : "R-HSA-8858252", "displayName" : "HDLBP binds HDL", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8858026, 265523 ], "outputs" : [ 8858255 ], "efs" : [ ], "diagramIds" : [ 432 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8980228, "stId" : "R-HSA-8980228", "displayName" : "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 109276, 171126 ], "outputs" : [ 174602, 174675 ], "catalysts" : [ 6789313 ], "efs" : [ ], "diagramIds" : [ 510 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8854408, "stId" : "R-HSA-8854408", "displayName" : "APOBR dimer binds VLDLs", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8866321 ], "inputs" : [ 8855875, 8854406 ], "outputs" : [ 8856140 ], "efs" : [ ], "diagramIds" : [ 322 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 9733403, "stId" : "R-HSA-9733403", "displayName" : "PCSK9 binds PCSK9 inhibitors", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 9733405, 6784727 ], "outputs" : [ 9733426 ], "efs" : [ ], "diagramIds" : [ 595 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8866327, "stId" : "R-HSA-8866327", "displayName" : "VLDL translocates from SER lumen to extracellular region", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8866304 ], "following" : [ 8866321 ], "inputs" : [ 8866319 ], "outputs" : [ 8866325 ], "efs" : [ ], "diagramIds" : [ 66 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 216723, "stId" : "R-HSA-216723", "displayName" : "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 6813720, 8937442, 216727 ], "following" : [ 349657, 216756 ], "inputs" : [ 29356, 216762, 113592 ], "outputs" : [ 29372, 29370, 171095 ], "catalysts" : [ 5682094 ], "efs" : [ ], "diagramIds" : [ 116 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 174739, "stId" : "R-HSA-174739", "displayName" : "chylomicron remnant + apoE => chylomicron remnant:apoE complex", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 174690 ], "following" : [ 174657 ], "inputs" : [ 174807, 174646 ], "outputs" : [ 174792 ], "efs" : [ ], "diagramIds" : [ 219 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6784628, "stId" : "R-HSA-6784628", "displayName" : "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 6784861 ], "inputs" : [ 8857969 ], "outputs" : [ 174605, 5216067, 1678620 ], "catalysts" : [ 6784618 ], "efs" : [ ], "activators" : [ 6784846, 6784897 ], "diagramIds" : [ 165 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 216727, "stId" : "R-HSA-216727", "displayName" : "4xPALM-C-p-2S-ABCA1 tetramer binds APOA1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 264758 ], "following" : [ 216757, 216723 ], "inputs" : [ 5682107, 174720 ], "outputs" : [ 5682094 ], "efs" : [ ], "diagramIds" : [ 108 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 264848, "stId" : "R-HSA-264848", "displayName" : "apoA-I binds to CUBN:AMN", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 264834 ], "inputs" : [ 264830, 174720 ], "outputs" : [ 264851 ], "efs" : [ ], "diagramIds" : [ 453 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8866321, "stId" : "R-HSA-8866321", "displayName" : "VLDL binds APOC1 and APOC4", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8866327 ], "following" : [ 8854408, 8854462 ], "inputs" : [ 5215930, 8866325, 8855541 ], "outputs" : [ 8855875 ], "efs" : [ ], "diagramIds" : [ 68 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 174741, "stId" : "R-HSA-174741", "displayName" : "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 174786 ], "following" : [ 174587 ], "inputs" : [ 174636, 174648, 174667, 174756, 174689, 174672, 174640 ], "outputs" : [ 174626 ], "efs" : [ ], "requirements" : [ 174681 ], "diagramIds" : [ 23 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8866329, "stId" : "R-HSA-8866329", "displayName" : "MTTP lipidates APOB-100, forming a pre-VLDL", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 8866308 ], "inputs" : [ 174671, 174779, 6784882 ], "outputs" : [ 6784871 ], "catalysts" : [ 174681 ], "efs" : [ ], "inhibitors" : [ 9737771 ], "diagramIds" : [ 40 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8876696, "stId" : "R-HSA-8876696", "displayName" : "SOAT1,2 transfer acyl group to CHOL forming CHEST", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8876485 ], "following" : [ 8876731 ], "inputs" : [ 193384, 1500578 ], "outputs" : [ 8876704, 76194 ], "catalysts" : [ 8876694 ], "efs" : [ ], "diagramIds" : [ 383 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 9737780, "stId" : "R-HSA-9737780", "displayName" : "MTTP binds lomitapide", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 174681, 9737774 ], "outputs" : [ 9737771 ], "efs" : [ ], "diagramIds" : [ 873 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 174624, "stId" : "R-HSA-174624", "displayName" : "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 174808 ], "following" : [ 171087 ], "inputs" : [ 174658 ], "outputs" : [ 171127, 174594 ], "efs" : [ ], "diagramIds" : [ 315 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8933292, "stId" : "R-HSA-8933292", "displayName" : "LSR trimer binds VLDL", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8933252, 8855875 ], "outputs" : [ 8933291 ], "efs" : [ ], "diagramIds" : [ 326 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 174757, "stId" : "R-HSA-174757", "displayName" : "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8857928, 174660 ], "following" : [ 174690 ], "inputs" : [ 174697 ], "outputs" : [ 174798, 174602, 174675 ], "catalysts" : [ 8857969 ], "efs" : [ ], "inhibitors" : [ 174725 ], "activators" : [ 174699, 174608 ], "diagramIds" : [ 207 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 171059, "stId" : "R-HSA-171059", "displayName" : "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 171141 ], "following" : [ 171106 ], "inputs" : [ 171108 ], "outputs" : [ 171056 ], "efs" : [ ], "diagramIds" : [ 350 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 264758, "stId" : "R-HSA-264758", "displayName" : "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 216727 ], "inputs" : [ 264771 ], "outputs" : [ 174720 ], "catalysts" : [ 264759 ], "efs" : [ ], "inhibitors" : [ 158255 ], "diagramIds" : [ 81 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 216757, "stId" : "R-HSA-216757", "displayName" : "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 216727 ], "following" : [ 349657, 216756 ], "inputs" : [ 29356, 113592, 216770 ], "outputs" : [ 29372, 29370, 171142 ], "catalysts" : [ 5682094 ], "efs" : [ ], "diagramIds" : [ 129 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 216756, "stId" : "R-HSA-216756", "displayName" : "Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 216757, 216723 ], "following" : [ 266089, 264678 ], "inputs" : [ 171095, 171142, 174720 ], "outputs" : [ 216752 ], "efs" : [ ], "diagramIds" : [ 135 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6784735, "stId" : "R-HSA-6784735", "displayName" : "PCSK9:LDLR bind to Clathrin", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 6784734 ], "following" : [ 6784729 ], "inputs" : [ 6784730, 177505 ], "outputs" : [ 6784733 ], "efs" : [ ], "diagramIds" : [ 416 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8854462, "stId" : "R-HSA-8854462", "displayName" : "VLDLR binds VLDL", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8866321 ], "inputs" : [ 8855875, 5216079 ], "outputs" : [ 8854464 ], "efs" : [ ], "diagramIds" : [ 319 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6784734, "stId" : "R-HSA-6784734", "displayName" : "PCSK9 binds LDLR", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 6784735 ], "inputs" : [ 171053, 6784727 ], "outputs" : [ 6784730 ], "efs" : [ ], "diagramIds" : [ 410 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6784861, "stId" : "R-HSA-6784861", "displayName" : "HSPG binds LPL dimer", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 6784628, 8857928 ], "inputs" : [ 1678620, 174592 ], "outputs" : [ 8867477 ], "efs" : [ ], "diagramIds" : [ 152 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 266303, "stId" : "R-HSA-266303", "displayName" : "Spherical HDL binds C and E apolipoproteins", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 174699, 265523, 174725, 174646 ], "outputs" : [ 174643 ], "efs" : [ ], "diagramIds" : [ 263 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8876731, "stId" : "R-HSA-8876731", "displayName" : "CHEST translocates from ER membrane to lipid particle", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8876696 ], "inputs" : [ 8876704 ], "outputs" : [ 163579 ], "efs" : [ ], "diagramIds" : [ 392 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6784729, "stId" : "R-HSA-6784729", "displayName" : "PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 6784735 ], "following" : [ 6784738 ], "inputs" : [ 6784733 ], "outputs" : [ 6784728 ], "efs" : [ ], "diagramIds" : [ 423 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 266299, "stId" : "R-HSA-266299", "displayName" : "Spherical HDL binds membrane-associated free cholesterol and phospholipids", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 266082 ], "inputs" : [ 265523, 171095, 171142 ], "outputs" : [ 8855688 ], "efs" : [ ], "activators" : [ 194227 ], "diagramIds" : [ 272 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8876472, "stId" : "R-HSA-8876472", "displayName" : "NPC2 binds CHOL", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8865667, 8876484 ], "following" : [ 8876484 ], "inputs" : [ 8876488, 8848047 ], "outputs" : [ 8876460 ], "efs" : [ ], "diagramIds" : [ 369 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 174786, "stId" : "R-HSA-174786", "displayName" : "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 174741 ], "inputs" : [ 174637, 174671, 174779 ], "outputs" : [ 174630 ], "catalysts" : [ 174681 ], "efs" : [ ], "diagramIds" : [ 21 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 349637, "stId" : "R-HSA-349637", "displayName" : "spherical HDL and SR-BI receptor form a complex at the cell surface", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 349638 ], "inputs" : [ 265523, 349415 ], "outputs" : [ 349649 ], "efs" : [ ], "diagramIds" : [ 437 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8855111, "stId" : "R-HSA-8855111", "displayName" : "VLDLR binds PCSK9", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 5216079, 6784727 ], "outputs" : [ 8855118 ], "efs" : [ ], "diagramIds" : [ 476 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 266310, "stId" : "R-HSA-266310", "displayName" : "LCAT:spherical HDL complex <=> LCAT + spherical HDL", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 266315 ], "inputs" : [ 266308 ], "outputs" : [ 194239, 265523 ], "efs" : [ ], "diagramIds" : [ 292 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8876485, "stId" : "R-HSA-8876485", "displayName" : "CHOL translocates from lysosome membrane to ER membrane", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 8876484 ], "following" : [ 8876696 ], "inputs" : [ 8876475 ], "outputs" : [ 193384, 5216153 ], "efs" : [ ], "diagramIds" : [ 377 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6784676, "stId" : "R-HSA-6784676", "displayName" : "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8857969 ], "outputs" : [ 174605, 5216067, 1678620 ], "catalysts" : [ 6784682 ], "efs" : [ ], "activators" : [ 6784897 ], "diagramIds" : [ 170 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 174657, "stId" : "R-HSA-174657", "displayName" : "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 171087, 174739 ], "following" : [ 174706 ], "inputs" : [ 171053, 174792 ], "outputs" : [ 174749 ], "efs" : [ ], "requirements" : [ 174603 ], "diagramIds" : [ 305 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 349638, "stId" : "R-HSA-349638", "displayName" : "Disassembly of SR-BI-bound spherical HDL", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 349637 ], "following" : [ 349657 ], "inputs" : [ 349649 ], "outputs" : [ 349645, 171095, 171142, 171057, 349415, 171075 ], "efs" : [ ], "diagramIds" : [ 502 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8876484, "stId" : "R-HSA-8876484", "displayName" : "NPC2 transfers CHOL to NPC1", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 8876472 ], "following" : [ 8876485, 8876472 ], "inputs" : [ 8876460, 5216153 ], "outputs" : [ 8876488, 8876475 ], "efs" : [ ], "diagramIds" : [ 372 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 174660, "stId" : "R-HSA-174660", "displayName" : "nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 174587 ], "following" : [ 174757 ], "inputs" : [ 174791, 174643 ], "outputs" : [ 174697, 265523 ], "efs" : [ ], "diagramIds" : [ 25 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8876366, "stId" : "R-HSA-8876366", "displayName" : "LDL translocates from endosome lumen to lysosome lumen", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 171106 ], "following" : [ 8865667 ], "inputs" : [ 171082 ], "outputs" : [ 8876367 ], "efs" : [ ], "diagramIds" : [ 358 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8856525, "stId" : "R-HSA-8856525", "displayName" : "ANGPTL8 binds ANGPTL3", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 6784850, 6784898 ], "outputs" : [ 6784846 ], "efs" : [ ], "diagramIds" : [ 160 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 5694109, "stId" : "R-HSA-5694109", "displayName" : "LIPC dimer hydrolyses TAG to DAG and FA", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 6785213 ], "inputs" : [ 109276, 171126 ], "outputs" : [ 422024, 174675 ], "catalysts" : [ 6785208 ], "efs" : [ ], "diagramIds" : [ 201 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 171087, "stId" : "R-HSA-171087", "displayName" : "LDLR [endosome membrane] => LDLR [plasma membrane]", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 174624, 171106 ], "following" : [ 174657, 171122 ], "inputs" : [ 171127 ], "outputs" : [ 171053 ], "efs" : [ ], "diagramIds" : [ 409 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 266315, "stId" : "R-HSA-266315", "displayName" : "LCAT + spherical HDL <=> LCAT:spherical HDL complex", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 266310 ], "inputs" : [ 194239, 265523 ], "outputs" : [ 266308 ], "efs" : [ ], "diagramIds" : [ 289 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8857928, "stId" : "R-HSA-8857928", "displayName" : "GPIHBP1 binds HSPG:LPL dimer", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 6784861 ], "following" : [ 174757 ], "inputs" : [ 5216067, 8867477 ], "outputs" : [ 8857969 ], "efs" : [ ], "diagramIds" : [ 156 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 349404, "stId" : "R-HSA-349404", "displayName" : "CETP + spherical HDL + torcetrapib => CETP:spherical HDL:torcetrapib complex", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 266351, 349405, 265523 ], "outputs" : [ 349410 ], "efs" : [ ], "diagramIds" : [ 1002 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6785213, "stId" : "R-HSA-6785213", "displayName" : "LIPC dimer binds heparin", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 6785178 ], "following" : [ 5694109 ], "inputs" : [ 6785179, 1604784 ], "outputs" : [ 6785208 ], "efs" : [ ], "diagramIds" : [ 198 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 174808, "stId" : "R-HSA-174808", "displayName" : "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 174706 ], "following" : [ 174624 ], "inputs" : [ 174816 ], "outputs" : [ 174658 ], "efs" : [ ], "diagramIds" : [ 312 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 349657, "stId" : "R-HSA-349657", "displayName" : "pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 216757, 349638, 216723 ], "inputs" : [ 349645, 171095, 171142 ], "outputs" : [ 216752 ], "efs" : [ ], "diagramIds" : [ 146 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 266328, "stId" : "R-HSA-266328", "displayName" : "CETP-mediated lipid exchange: spherical HDL gains triacylglycerol", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 266350 ], "following" : [ 266350 ], "inputs" : [ 266351, 265523 ], "outputs" : [ 266348, 266340 ], "efs" : [ ], "diagramIds" : [ 294 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8855131, "stId" : "R-HSA-8855131", "displayName" : "VLDLR:PCSK9 binds Clathrin-coated vesicles", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 8855118, 177505 ], "outputs" : [ 8855134 ], "efs" : [ ], "diagramIds" : [ 481 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8855130, "stId" : "R-HSA-8855130", "displayName" : "VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "inputs" : [ 8855134 ], "outputs" : [ 8855135 ], "efs" : [ ], "diagramIds" : [ 486 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 174690, "stId" : "R-HSA-174690", "displayName" : "TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 174757 ], "following" : [ 174739 ], "inputs" : [ 174798, 265523 ], "outputs" : [ 174807, 174769 ], "efs" : [ ], "diagramIds" : [ 216 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 171106, "stId" : "R-HSA-171106", "displayName" : "LDLR:LDL complex => LDLR + LDL", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 171059 ], "following" : [ 8876366, 171087 ], "inputs" : [ 171056 ], "outputs" : [ 171082, 171127 ], "efs" : [ ], "diagramIds" : [ 354 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 5682103, "stId" : "R-HSA-5682103", "displayName" : "4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 5682084 ], "following" : [ 5682101 ], "inputs" : [ 5682067 ], "outputs" : [ 5682073 ], "efs" : [ ], "diagramIds" : [ 95 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 264678, "stId" : "R-HSA-264678", "displayName" : "LCAT + discoidal HDL <=> LCAT:discoidal HDL complex", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 216756 ], "inputs" : [ 194239, 216752 ], "outputs" : [ 264684 ], "efs" : [ ], "diagramIds" : [ 258 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 5682101, "stId" : "R-HSA-5682101", "displayName" : "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 5682103 ], "inputs" : [ 5682073, 113592 ], "outputs" : [ 5682107, 29370 ], "catalysts" : [ 111920 ], "efs" : [ ], "diagramIds" : [ 100 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 264679, "stId" : "R-HSA-264679", "displayName" : "Serum albumin binds 2-lysophosphatidylcholine", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 264695 ], "inputs" : [ 194236, 194115 ], "outputs" : [ 264677 ], "efs" : [ ], "diagramIds" : [ 286 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8854628, "stId" : "R-HSA-8854628", "displayName" : "MYLIP dimer ubiquitinates VLDLR on Lys-839", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 450143, 5216079 ], "outputs" : [ 8855136 ], "catalysts" : [ 8855129 ], "efs" : [ ], "activators" : [ 8854954 ], "diagramIds" : [ 465 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 266082, "stId" : "R-HSA-266082", "displayName" : "ABCG1-mediated transport of intracellular cholesterol to the cell surface", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 266299, 266089 ], "inputs" : [ 29356, 216762, 113592 ], "outputs" : [ 29372, 29370, 171095 ], "catalysts" : [ 194222 ], "efs" : [ ], "diagramIds" : [ 243 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 266350, "stId" : "R-HSA-266350", "displayName" : "CETP-mediated lipid exchange: LDL gains cholesterol ester", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 266328 ], "following" : [ 266328 ], "inputs" : [ 171131, 266340 ], "outputs" : [ 266351, 266339 ], "efs" : [ ], "inhibitors" : [ 5216090 ], "diagramIds" : [ 227 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 8937442, "stId" : "R-HSA-8937442", "displayName" : "CES3 hydrolyses CHEST to CHOL and LCFA(-)", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 216723 ], "inputs" : [ 29356, 163579 ], "outputs" : [ 8876730, 216762 ], "catalysts" : [ 8937441 ], "efs" : [ ], "diagramIds" : [ 402 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 176879, "stId" : "R-HSA-176879", "displayName" : "apolipoprotein(a) + LDL => Lp(a)", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 176877, 171131 ], "outputs" : [ 176866 ], "efs" : [ ], "diagramIds" : [ 234 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 266089, "stId" : "R-HSA-266089", "displayName" : "Discoidal HDL binds membrane-associated free cholesterol", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 216756, 266082 ], "inputs" : [ 171095, 216752 ], "outputs" : [ 266083 ], "efs" : [ ], "diagramIds" : [ 255 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6784648, "stId" : "R-HSA-6784648", "displayName" : "CREB3L3 (1-?) translocates from cytosol to nucleoplasm", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 6784620 ], "following" : [ 6784622 ], "inputs" : [ 6784654 ], "outputs" : [ 6784629 ], "efs" : [ ], "diagramIds" : [ 183 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 174706, "stId" : "R-HSA-174706", "displayName" : "chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 174657 ], "following" : [ 174808 ], "inputs" : [ 174749 ], "outputs" : [ 174816 ], "efs" : [ ], "requirements" : [ 171143 ], "diagramIds" : [ 309 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 171122, "stId" : "R-HSA-171122", "displayName" : "LDL + LDLR => LDL:LDLR complex", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 171087 ], "following" : [ 171141 ], "inputs" : [ 171053, 171131 ], "outputs" : [ 171100 ], "efs" : [ ], "diagramIds" : [ 337 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 5682084, "stId" : "R-HSA-5682084", "displayName" : "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 5682103 ], "inputs" : [ 200993, 5682087 ], "outputs" : [ 5682067, 76194 ], "catalysts" : [ 5215972 ], "efs" : [ ], "diagramIds" : [ 89 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 264695, "stId" : "R-HSA-264695", "displayName" : "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 264679 ], "inputs" : [ 171149, 382539 ], "outputs" : [ 194236, 171076 ], "catalysts" : [ 194239 ], "efs" : [ ], "activators" : [ 174720 ], "diagramIds" : [ 277 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 264689, "stId" : "R-HSA-264689", "displayName" : "LCAT:discoidal HDL complex <=> LCAT + discoidal HDL", "schemaClass" : "Reaction", "speciesId" : 0, "inputs" : [ 264684 ], "outputs" : [ 194239, 216752 ], "efs" : [ ], "diagramIds" : [ 262 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 174587, "stId" : "R-HSA-174587", "displayName" : "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular]", "schemaClass" : "Reaction", "speciesId" : 0, "preceding" : [ 174741 ], "following" : [ 174660 ], "inputs" : [ 174626 ], "outputs" : [ 174791 ], "efs" : [ ], "requirements" : [ 174678 ], "diagramIds" : [ 24 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6785181, "stId" : "R-HSA-6785181", "displayName" : "LMF1,2 bind LIPC dimer", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 6785178 ], "inputs" : [ 6785148, 6785190 ], "outputs" : [ 6785173 ], "efs" : [ ], "diagramIds" : [ 190 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6785178, "stId" : "R-HSA-6785178", "displayName" : "LMF1,2 transport LIPC dimer from ER lumen to extracellular region", "schemaClass" : "BlackBoxEvent", "speciesId" : 0, "preceding" : [ 6785181 ], "following" : [ 6785213 ], "inputs" : [ 6785173 ], "outputs" : [ 6785179, 6785148 ], "efs" : [ ], "diagramIds" : [ 195 ], "entityFunctionalStatus" : [ ] }, { "dbId" : 6813720, "stId" : "R-HSA-6813720", "displayName" : "NCEH1 hydrolyzes cholesterol esters", "schemaClass" : "Reaction", "speciesId" : 0, "following" : [ 216723 ], "inputs" : [ 29356, 163579 ], "outputs" : [ 8876730, 216762 ], "catalysts" : [ 6813685 ], "efs" : [ ], "diagramIds" : [ 396 ], "entityFunctionalStatus" : [ ] } ], "subpathways" : [ { "dbId" : 8963888, "stId" : "R-HSA-8963888", "displayName" : "Chylomicron assembly", "events" : [ 174786, 174660, 174741, 174731, 174587 ] }, { "dbId" : 8964043, "stId" : "R-HSA-8964043", "displayName" : "Plasma lipoprotein clearance", "events" : [ 174706, 174624, 174657, 174808, 349637, 349638, 264848, 264834, 8858252, 8933292, 8854462, 8854408, 8855111, 8854628, 8855131, 8855130, 171106, 8933258, 8876485, 8876484, 8865667, 6784738, 171141, 8876366, 8937442, 171087, 9733403, 171122, 171059, 6784735, 6784734, 8876731, 6784729, 8876472, 8876696, 6813720 ] }, { "dbId" : 8866427, "stId" : "R-HSA-8866427", "displayName" : "VLDLR internalisation and degradation", "events" : [ 8855111, 8854628, 8855131, 8855130 ] }, { "dbId" : 8963899, "stId" : "R-HSA-8963899", "displayName" : "Plasma lipoprotein remodeling", "events" : [ 9737780, 266350, 176879, 264678, 266310, 264679, 266082, 266089, 8980228, 266315, 264695, 264689, 349404, 266303, 266328, 266299, 174690, 174739, 174757, 6784628, 6784676, 6784622, 6784861, 8856525, 6785181, 6785213, 6784620, 5694109, 6785178, 8857928, 6784648 ] }, { "dbId" : 8963898, "stId" : "R-HSA-8963898", "displayName" : "Plasma lipoprotein assembly", "events" : [ 8866327, 8866308, 8866321, 8866304, 8866329, 216723, 5682103, 264758, 5682084, 5682101, 216727, 216757, 216756, 349657, 174786, 174660, 174741, 174731, 174587 ] }, { "dbId" : 8963889, "stId" : "R-HSA-8963889", "displayName" : "Assembly of active LPL and LIPC lipase complexes", "events" : [ 6784628, 6784676, 6784622, 6784861, 8856525, 6785181, 6785213, 6784620, 5694109, 6785178, 8857928, 6784648 ] }, { "dbId" : 8866423, "stId" : "R-HSA-8866423", "displayName" : "VLDL assembly", "events" : [ 8866327, 8866308, 8866321, 8866304, 8866329 ] }, { "dbId" : 8963896, "stId" : "R-HSA-8963896", "displayName" : "HDL assembly", "events" : [ 216723, 5682103, 264758, 5682084, 5682101, 216727, 216757, 216756, 349657 ] }, { "dbId" : 8963901, "stId" : "R-HSA-8963901", "displayName" : "Chylomicron remodeling", "events" : [ 174690, 174739, 174757 ] }, { "dbId" : 8964058, "stId" : "R-HSA-8964058", "displayName" : "HDL remodeling", "events" : [ 264678, 266310, 264679, 266082, 266089, 8980228, 266315, 264695, 264689, 349404, 266303, 266328, 266299 ] }, { "dbId" : 8964041, "stId" : "R-HSA-8964041", "displayName" : "LDL remodeling", "events" : [ 9737780, 266350, 176879 ] }, { "dbId" : 8964046, "stId" : "R-HSA-8964046", "displayName" : "VLDL clearance", "events" : [ 8933292, 8854462, 8854408 ] }, { "dbId" : 8964038, "stId" : "R-HSA-8964038", "displayName" : "LDL clearance", "events" : [ 171106, 8933258, 8876485, 8876484, 8865667, 6784738, 171141, 8876366, 8937442, 171087, 9733403, 171122, 171059, 6784735, 6784734, 8876731, 6784729, 8876472, 8876696, 6813720 ] }, { "dbId" : 8964026, "stId" : "R-HSA-8964026", "displayName" : "Chylomicron clearance", "events" : [ 174706, 174624, 174657, 174808 ] }, { "dbId" : 8964011, "stId" : "R-HSA-8964011", "displayName" : "HDL clearance", "events" : [ 349637, 349638, 264848, 264834, 8858252 ] } ] }