{ "dbId" : 1433557, "stableId" : "R-HSA-1433557", "displayName" : "Signaling by SCF-KIT", "forNormalDraw" : true, "nodes" : [ { "id" : 768, "reactomeId" : 1470001, "displayName" : "SOCS6:p-c-Kit:sSCF dimer:p-c-Kit", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1349, "y" : 543 }, "minX" : 1298, "maxX" : 1407, "minY" : 513, "maxY" : 567, "prop" : { "x" : 1298, "y" : 519, "width" : 103, "height" : 48 }, "textPosition" : { "x" : 1302, "y" : 518 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1401, "y" : 519 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1401, "y" : 519 } } }, "connectors" : [ { "edgeId" : 766, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1024, "reactomeId" : 5673001, "displayName" : "RAF/MAP kinase cascade", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 511, "y" : 787 }, "minX" : 445, "maxX" : 577, "minY" : 751, "maxY" : 824, "prop" : { "x" : 445, "y" : 751, "width" : 132, "height" : 73 }, "textPosition" : { "x" : 452, "y" : 766 }, "connectors" : [ ] }, { "id" : 769, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 261, "y" : 574 }, "minX" : 240, "maxX" : 282, "minY" : 415, "maxY" : 589, "prop" : { "x" : 241, "y" : 559, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 245, "y" : 563 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 276, "y" : 564 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 276, "y" : 564 } } }, "connectors" : [ { "edgeId" : 412, "type" : "INPUT", "segments" : [ { "from" : { "x" : 259, "y" : 556 }, "to" : { "x" : 240, "y" : 415 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 243, "y" : 479 }, "b" : { "x" : 255, "y" : 491 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 249, "y" : 485 } } } } ] }, { "id" : 770, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 132, "y" : 574 }, "minX" : 112, "maxX" : 175, "minY" : 417, "maxY" : 589, "prop" : { "x" : 112, "y" : 559, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 116, "y" : 563 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 148, "y" : 564 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 148, "y" : 564 } } }, "connectors" : [ { "edgeId" : 412, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 136, "y" : 556 }, "to" : { "x" : 175, "y" : 417 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 149, "y" : 480 }, "b" : { "x" : 161, "y" : 492 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 155, "y" : 486 } } }, "endShape" : { "a" : { "x" : 134, "y" : 548 }, "b" : { "x" : 136, "y" : 556 }, "c" : { "x" : 142, "y" : 550 }, "type" : "ARROW", "centre" : { "x" : 142, "y" : 550 } } } ] }, { "id" : 2, "reactomeId" : 708323, "displayName" : "KITLG-1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 204, "y" : 144 }, "minX" : 160, "maxX" : 254, "minY" : 127, "maxY" : 155, "prop" : { "x" : 160, "y" : 133, "width" : 88, "height" : 22 }, "textPosition" : { "x" : 178, "y" : 133 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 248, "y" : 133 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 248, "y" : 133 } } }, "connectors" : [ { "edgeId" : 1, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1027, "reactomeId" : 9031773, "displayName" : "PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1797, "y" : 909 }, "minX" : 1703, "maxX" : 1891, "minY" : 521, "maxY" : 940, "prop" : { "x" : 1703, "y" : 878, "width" : 188, "height" : 62 }, "textPosition" : { "x" : 1708, "y" : 884 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 53, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1798, "y" : 872 }, "to" : { "x" : 1811, "y" : 529 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1812, "y" : 525 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1812, "y" : 525 } } } ] }, { "id" : 3, "reactomeId" : 708330, "displayName" : "KITLG-1(26-190)", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 369, "y" : 86 }, "minX" : 258, "maxX" : 431, "minY" : 63, "maxY" : 103, "prop" : { "x" : 334, "y" : 69, "width" : 71, "height" : 34 }, "textPosition" : { "x" : 338, "y" : 69 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 405, "y" : 69 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 405, "y" : 69 } } }, "connectors" : [ { "edgeId" : 1, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 331, "y" : 88 }, "to" : { "x" : 258, "y" : 93 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 324, "y" : 92 }, "b" : { "x" : 331, "y" : 88 }, "c" : { "x" : 324, "y" : 84 }, "type" : "ARROW", "centre" : { "x" : 324, "y" : 84 } } }, { "edgeId" : 6, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 419, "y" : 82 }, "b" : { "x" : 431, "y" : 94 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 425, "y" : 88 } } } } ] }, { "id" : 388, "reactomeId" : 1433353, "displayName" : "Tyrosine kinases", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1523, "y" : 600 }, "minX" : 1476, "maxX" : 1571, "minY" : 373, "maxY" : 620, "prop" : { "x" : 1476, "y" : 580, "width" : 95, "height" : 40 }, "textPosition" : { "x" : 1491, "y" : 582 }, "connectors" : [ { "edgeId" : 387, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1527, "y" : 574 }, "to" : { "x" : 1562, "y" : 420 } }, { "from" : { "x" : 1562, "y" : 420 }, "to" : { "x" : 1538, "y" : 373 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 4, "reactomeId" : 708322, "displayName" : "KITLG-1(192-273)", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 352, "y" : 24 }, "minX" : 258, "maxX" : 399, "minY" : 0, "maxY" : 93, "prop" : { "x" : 312, "y" : 6, "width" : 81, "height" : 36 }, "textPosition" : { "x" : 317, "y" : 6 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 393, "y" : 6 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 393, "y" : 6 } } }, "connectors" : [ { "edgeId" : 1, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 327, "y" : 45 }, "to" : { "x" : 258, "y" : 93 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 324, "y" : 52 }, "b" : { "x" : 327, "y" : 45 }, "c" : { "x" : 319, "y" : 46 }, "type" : "ARROW", "centre" : { "x" : 319, "y" : 46 } } } ] }, { "id" : 389, "reactomeId" : 205201, "displayName" : "Tyrosine kinases:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1619, "y" : 509 }, "minX" : 1573, "maxX" : 1672, "minY" : 481, "maxY" : 532, "prop" : { "x" : 1573, "y" : 487, "width" : 93, "height" : 45 }, "textPosition" : { "x" : 1573, "y" : 483 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1666, "y" : 487 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1666, "y" : 487 } } }, "connectors" : [ { "edgeId" : 387, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 5, "reactomeId" : 1433401, "displayName" : "Endopeptidases for SCF processing", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 206, "y" : 30 }, "minX" : 143, "maxX" : 269, "minY" : 12, "maxY" : 87, "prop" : { "x" : 143, "y" : 12, "width" : 126, "height" : 36 }, "textPosition" : { "x" : 143, "y" : 12 }, "connectors" : [ { "edgeId" : 1, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 205, "y" : 54 }, "to" : { "x" : 204, "y" : 79 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 204, "y" : 83 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 204, "y" : 83 } } } ] }, { "id" : 517, "reactomeId" : 109796, "displayName" : "p21 RAS:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 799, "y" : 673 }, "minX" : 755, "maxX" : 849, "minY" : 656, "maxY" : 743, "prop" : { "x" : 755, "y" : 662, "width" : 88, "height" : 22 }, "textPosition" : { "x" : 767, "y" : 649 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 843, "y" : 662 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 843, "y" : 662 } } }, "connectors" : [ { "edgeId" : 323, "type" : "INPUT", "segments" : [ { "from" : { "x" : 793, "y" : 687 }, "to" : { "x" : 767, "y" : 743 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 7, "reactomeId" : 1433307, "displayName" : "sSCF dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 509, "y" : 90 }, "minX" : 473, "maxX" : 552, "minY" : 73, "maxY" : 361, "prop" : { "x" : 473, "y" : 79, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 488, "y" : 66 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 546, "y" : 79 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 546, "y" : 79 } } }, "connectors" : [ { "edgeId" : 6, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8, "type" : "INPUT", "segments" : [ { "from" : { "x" : 507, "y" : 104 }, "to" : { "x" : 477, "y" : 361 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 391, "reactomeId" : 1433422, "displayName" : "Adapter proteins", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1143, "y" : 635 }, "minX" : 1090, "maxX" : 1197, "minY" : 414, "maxY" : 646, "prop" : { "x" : 1090, "y" : 624, "width" : 107, "height" : 22 }, "textPosition" : { "x" : 1112, "y" : 618 }, "connectors" : [ { "edgeId" : 390, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1143, "y" : 618 }, "to" : { "x" : 1160, "y" : 414 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 392, "reactomeId" : 1433538, "displayName" : "Adapter proteins:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1224, "y" : 494 }, "minX" : 1191, "maxX" : 1263, "minY" : 456, "maxY" : 527, "prop" : { "x" : 1191, "y" : 462, "width" : 66, "height" : 65 }, "textPosition" : { "x" : 1192, "y" : 464 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1257, "y" : 462 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1257, "y" : 462 } } }, "connectors" : [ { "edgeId" : 390, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 521, "reactomeId" : 109783, "displayName" : "p21 RAS:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 617, "y" : 647 }, "minX" : 574, "maxX" : 683, "minY" : 630, "maxY" : 741, "prop" : { "x" : 574, "y" : 636, "width" : 87, "height" : 22 }, "textPosition" : { "x" : 585, "y" : 623 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 661, "y" : 636 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 661, "y" : 636 } } }, "connectors" : [ { "edgeId" : 323, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 624, "y" : 661 }, "to" : { "x" : 683, "y" : 741 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 631, "y" : 664 }, "b" : { "x" : 624, "y" : 661 }, "c" : { "x" : 625, "y" : 669 }, "type" : "ARROW", "centre" : { "x" : 625, "y" : 669 } } } ] }, { "id" : 10, "reactomeId" : 197662, "displayName" : "KIT", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 307, "y" : 417 }, "minX" : 240, "maxX" : 653, "minY" : 358, "maxY" : 489, "prop" : { "x" : 293, "y" : 406, "width" : 28, "height" : 22 }, "textPosition" : { "x" : 294, "y" : 406 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 321, "y" : 406 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 321, "y" : 406 } } }, "connectors" : [ { "edgeId" : 8, "type" : "INPUT", "segments" : [ { "from" : { "x" : 324, "y" : 412 }, "to" : { "x" : 477, "y" : 361 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1423, "type" : "INPUT", "segments" : [ { "from" : { "x" : 324, "y" : 425 }, "to" : { "x" : 432, "y" : 489 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 19, "type" : "INPUT", "segments" : [ { "from" : { "x" : 324, "y" : 416 }, "to" : { "x" : 603, "y" : 408 } }, { "from" : { "x" : 603, "y" : 408 }, "to" : { "x" : 653, "y" : 358 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 412, "type" : "INPUT", "segments" : [ { "from" : { "x" : 290, "y" : 416 }, "to" : { "x" : 240, "y" : 415 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 487, "type" : "INPUT", "segments" : [ { "from" : { "x" : 314, "y" : 403 }, "to" : { "x" : 336, "y" : 373 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1343, "type" : "INPUT", "segments" : [ { "from" : { "x" : 313, "y" : 431 }, "to" : { "x" : 337, "y" : 472 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 11, "reactomeId" : 205166, "displayName" : "KIT:sSCF dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 566, "y" : 360 }, "minX" : 533, "maxX" : 653, "minY" : 334, "maxY" : 380, "prop" : { "x" : 533, "y" : 340, "width" : 66, "height" : 40 }, "textPosition" : { "x" : 534, "y" : 345 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 599, "y" : 340 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 599, "y" : 340 } } }, "connectors" : [ { "edgeId" : 8, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 19, "type" : "INPUT", "segments" : [ { "from" : { "x" : 602, "y" : 359 }, "to" : { "x" : 653, "y" : 358 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 396, "reactomeId" : 210620, "displayName" : "JAK2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2297, "y" : 546 }, "minX" : 2265, "maxX" : 2322, "minY" : 285, "maxY" : 557, "prop" : { "x" : 2279, "y" : 535, "width" : 37, "height" : 22 }, "textPosition" : { "x" : 2280, "y" : 535 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2316, "y" : 535 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2316, "y" : 535 } } }, "connectors" : [ { "edgeId" : 395, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2295, "y" : 532 }, "to" : { "x" : 2265, "y" : 285 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2274, "y" : 402 }, "b" : { "x" : 2286, "y" : 414 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2280, "y" : 408 } } } } ] }, { "id" : 397, "reactomeId" : 1433493, "displayName" : "JAK2:SFKS:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2358, "y" : 301 }, "minX" : 2310, "maxX" : 2412, "minY" : 276, "maxY" : 368, "prop" : { "x" : 2310, "y" : 282, "width" : 96, "height" : 38 }, "textPosition" : { "x" : 2316, "y" : 285 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2406, "y" : 282 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2406, "y" : 282 } } }, "connectors" : [ { "edgeId" : 395, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1373, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2355, "y" : 323 }, "to" : { "x" : 2352, "y" : 350 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1373, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2335, "y" : 323 }, "to" : { "x" : 2313, "y" : 339 } }, { "from" : { "x" : 2313, "y" : 339 }, "to" : { "x" : 2341, "y" : 361 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2345, "y" : 364 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2345, "y" : 364 } } } ] }, { "id" : 1424, "reactomeId" : 9674322, "displayName" : "ripretinib", "schemaClass" : "ChemicalDrug", "renderableClass" : "ChemicalDrug", "position" : { "x" : 458, "y" : 624 }, "isDisease" : true, "minX" : 415, "maxX" : 501, "minY" : 489, "maxY" : 644, "prop" : { "x" : 415, "y" : 605, "width" : 86, "height" : 39 }, "textPosition" : { "x" : 426, "y" : 614 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 1423, "type" : "INPUT", "segments" : [ { "from" : { "x" : 454, "y" : 602 }, "to" : { "x" : 432, "y" : 489 } } ], "stoichiometry" : { "value" : 1 }, "isDisease" : true } ] }, { "id" : 401, "reactomeId" : 1433552, "displayName" : "p-JAK2:SFKs:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2362, "y" : 446 }, "minX" : 2311, "maxX" : 2799, "minY" : 388, "maxY" : 620, "prop" : { "x" : 2311, "y" : 428, "width" : 102, "height" : 37 }, "textPosition" : { "x" : 2314, "y" : 430 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2413, "y" : 428 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2413, "y" : 428 } } }, "connectors" : [ { "edgeId" : 404, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2416, "y" : 447 }, "to" : { "x" : 2492, "y" : 450 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1373, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2360, "y" : 425 }, "to" : { "x" : 2357, "y" : 388 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2355, "y" : 418 }, "b" : { "x" : 2360, "y" : 425 }, "c" : { "x" : 2363, "y" : 418 }, "type" : "ARROW", "centre" : { "x" : 2363, "y" : 418 } } }, { "edgeId" : 678, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2363, "y" : 468 }, "to" : { "x" : 2372, "y" : 615 } }, { "from" : { "x" : 2372, "y" : 615 }, "to" : { "x" : 2799, "y" : 620 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2367, "y" : 475 }, "b" : { "x" : 2363, "y" : 468 }, "c" : { "x" : 2359, "y" : 475 }, "type" : "ARROW", "centre" : { "x" : 2359, "y" : 475 } } } ] }, { "id" : 1425, "reactomeId" : 9681373, "displayName" : "KIT:ripretinib", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 556, "y" : 485 }, "isDisease" : true, "minX" : 495, "maxX" : 905, "minY" : 361, "maxY" : 502, "prop" : { "x" : 495, "y" : 468, "width" : 123, "height" : 34 }, "textPosition" : { "x" : 514, "y" : 481 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 618, "y" : 468 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 618, "y" : 468 } } }, "connectors" : [ { "edgeId" : 1423, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 }, "isDisease" : true }, { "edgeId" : 22, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 621, "y" : 475 }, "to" : { "x" : 793, "y" : 449 } }, { "from" : { "x" : 793, "y" : 449 }, "to" : { "x" : 903, "y" : 364 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 901, "y" : 361 }, "b" : { "x" : 905, "y" : 367 }, "c" : { "x" : 903, "y" : 364 }, "type" : "STOP", "centre" : { "x" : 903, "y" : 364 } } } ] }, { "id" : 20, "reactomeId" : 205208, "displayName" : "KIT:sSCF dimer:KIT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 767, "y" : 359 }, "minX" : 645, "maxX" : 902, "minY" : 342, "maxY" : 490, "prop" : { "x" : 708, "y" : 348, "width" : 119, "height" : 22 }, "textPosition" : { "x" : 708, "y" : 349 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 827, "y" : 348 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 827, "y" : 348 } } }, "connectors" : [ { "edgeId" : 1352, "type" : "INPUT", "segments" : [ { "from" : { "x" : 756, "y" : 373 }, "to" : { "x" : 645, "y" : 490 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 19, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22, "type" : "INPUT", "segments" : [ { "from" : { "x" : 830, "y" : 358 }, "to" : { "x" : 870, "y" : 358 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 830, "y" : 368 }, "to" : { "x" : 845, "y" : 372 } }, { "from" : { "x" : 845, "y" : 372 }, "to" : { "x" : 894, "y" : 362 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 898, "y" : 361 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 898, "y" : 361 } } } ] }, { "id" : 406, "reactomeId" : 1433551, "displayName" : "STATs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2475, "y" : 572 }, "minX" : 2453, "maxX" : 2498, "minY" : 450, "maxY" : 583, "prop" : { "x" : 2453, "y" : 561, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 2453, "y" : 561 }, "connectors" : [ { "edgeId" : 404, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2476, "y" : 555 }, "to" : { "x" : 2492, "y" : 450 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2478, "y" : 496 }, "b" : { "x" : 2490, "y" : 508 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2484, "y" : 502 } } } } ] }, { "id" : 407, "reactomeId" : 1433527, "displayName" : "p-JAK2:SFKs:p-KIT complex:STATs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2552, "y" : 501 }, "minX" : 2501, "maxX" : 2652, "minY" : 447, "maxY" : 524, "prop" : { "x" : 2501, "y" : 478, "width" : 103, "height" : 46 }, "textPosition" : { "x" : 2505, "y" : 475 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2604, "y" : 478 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2604, "y" : 478 } } }, "connectors" : [ { "edgeId" : 404, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 672, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2607, "y" : 503 }, "to" : { "x" : 2628, "y" : 504 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 672, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2589, "y" : 475 }, "to" : { "x" : 2639, "y" : 447 } }, { "from" : { "x" : 2639, "y" : 447 }, "to" : { "x" : 2647, "y" : 487 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2648, "y" : 491 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2648, "y" : 491 } } } ] }, { "id" : 23, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 828, "y" : 314 }, "minX" : 808, "maxX" : 870, "minY" : 298, "maxY" : 358, "prop" : { "x" : 808, "y" : 299, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 812, "y" : 303 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 843, "y" : 304 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 843, "y" : 304 } } }, "connectors" : [ { "edgeId" : 22, "type" : "INPUT", "segments" : [ { "from" : { "x" : 842, "y" : 332 }, "to" : { "x" : 870, "y" : 358 } } ], "stoichiometry" : { "value" : 14, "shape" : { "a" : { "x" : 850, "y" : 339 }, "b" : { "x" : 862, "y" : 351 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 856, "y" : 345 } } } } ] }, { "id" : 24, "reactomeId" : 205310, "displayName" : "p-7Y-KIT:sSCF dimer:p-7Y-KIT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1037, "y" : 353 }, "minX" : 860, "maxX" : 2006, "minY" : 329, "maxY" : 537, "prop" : { "x" : 986, "y" : 335, "width" : 103, "height" : 36 }, "textPosition" : { "x" : 990, "y" : 336 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1089, "y" : 335 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1089, "y" : 335 } } }, "connectors" : [ { "edgeId" : 387, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1092, "y" : 355 }, "to" : { "x" : 1538, "y" : 373 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 390, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1073, "y" : 374 }, "to" : { "x" : 1160, "y" : 414 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 454, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1035, "y" : 374 }, "to" : { "x" : 1031, "y" : 434 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 71, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1027, "y" : 374 }, "to" : { "x" : 987, "y" : 443 } }, { "from" : { "x" : 987, "y" : 443 }, "to" : { "x" : 860, "y" : 537 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 983, "y" : 355 }, "to" : { "x" : 926, "y" : 359 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 976, "y" : 359 }, "b" : { "x" : 983, "y" : 355 }, "c" : { "x" : 976, "y" : 351 }, "type" : "ARROW", "centre" : { "x" : 976, "y" : 351 } } }, { "edgeId" : 416, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1031, "y" : 374 }, "to" : { "x" : 1012, "y" : 428 } }, { "from" : { "x" : 1012, "y" : 428 }, "to" : { "x" : 955, "y" : 490 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 40, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1092, "y" : 352 }, "to" : { "x" : 2006, "y" : 348 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 1008, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1092, "y" : 357 }, "to" : { "x" : 1415, "y" : 384 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 50, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1092, "y" : 353 }, "to" : { "x" : 1724, "y" : 366 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 766, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1092, "y" : 369 }, "to" : { "x" : 1287, "y" : 432 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 25, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 957, "y" : 313 }, "minX" : 926, "maxX" : 979, "minY" : 297, "maxY" : 359, "prop" : { "x" : 937, "y" : 298, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 941, "y" : 302 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 973, "y" : 303 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 973, "y" : 303 } } }, "connectors" : [ { "edgeId" : 22, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 946, "y" : 331 }, "to" : { "x" : 926, "y" : 359 } } ], "stoichiometry" : { "value" : 14, "shape" : { "a" : { "x" : 930, "y" : 339 }, "b" : { "x" : 942, "y" : 351 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 936, "y" : 345 } } }, "endShape" : { "a" : { "x" : 945, "y" : 339 }, "b" : { "x" : 946, "y" : 331 }, "c" : { "x" : 939, "y" : 334 }, "type" : "ARROW", "centre" : { "x" : 939, "y" : 334 } } } ] }, { "id" : 28, "reactomeId" : 1433473, "displayName" : "p-KIT (S741,746):PKC alpha", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 90, "y" : 419 }, "minX" : 32, "maxX" : 912, "minY" : 293, "maxY" : 437, "prop" : { "x" : 32, "y" : 401, "width" : 117, "height" : 36 }, "textPosition" : { "x" : 33, "y" : 402 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 149, "y" : 401 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 149, "y" : 401 } } }, "connectors" : [ { "edgeId" : 22, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 114, "y" : 398 }, "to" : { "x" : 263, "y" : 293 } }, { "from" : { "x" : 263, "y" : 293 }, "to" : { "x" : 892, "y" : 293 } }, { "from" : { "x" : 892, "y" : 293 }, "to" : { "x" : 908, "y" : 350 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 904, "y" : 351 }, "b" : { "x" : 912, "y" : 349 }, "c" : { "x" : 908, "y" : 350 }, "type" : "STOP", "centre" : { "x" : 908, "y" : 350 } } }, { "edgeId" : 412, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 152, "y" : 417 }, "to" : { "x" : 175, "y" : 417 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 159, "y" : 413 }, "b" : { "x" : 152, "y" : 417 }, "c" : { "x" : 159, "y" : 421 }, "type" : "ARROW", "centre" : { "x" : 159, "y" : 421 } } } ] }, { "id" : 413, "reactomeId" : 58196, "displayName" : "PRKCA", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 202, "y" : 570 }, "minX" : 171, "maxX" : 240, "minY" : 415, "maxY" : 585, "prop" : { "x" : 171, "y" : 556, "width" : 62, "height" : 29 }, "textPosition" : { "x" : 178, "y" : 560 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 233, "y" : 556 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 233, "y" : 556 } } }, "connectors" : [ { "edgeId" : 412, "type" : "INPUT", "segments" : [ { "from" : { "x" : 205, "y" : 553 }, "to" : { "x" : 240, "y" : 415 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 412, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 201, "y" : 553 }, "to" : { "x" : 198, "y" : 434 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 198, "y" : 430 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 198, "y" : 430 } } } ] }, { "id" : 417, "reactomeId" : 197938, "displayName" : "PTPN6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 908, "y" : 554 }, "minX" : 884, "maxX" : 955, "minY" : 490, "maxY" : 565, "prop" : { "x" : 884, "y" : 544, "width" : 49, "height" : 21 }, "textPosition" : { "x" : 884, "y" : 544 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 933, "y" : 544 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 933, "y" : 544 } } }, "connectors" : [ { "edgeId" : 416, "type" : "INPUT", "segments" : [ { "from" : { "x" : 915, "y" : 541 }, "to" : { "x" : 955, "y" : 490 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 675, "reactomeId" : 1470000, "displayName" : "p-JAK2:SFKs:p-KIT complex:p-STATs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2749, "y" : 499 }, "minX" : 2668, "maxX" : 2810, "minY" : 460, "maxY" : 533, "prop" : { "x" : 2694, "y" : 466, "width" : 110, "height" : 67 }, "textPosition" : { "x" : 2701, "y" : 484 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2804, "y" : 466 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2804, "y" : 466 } } }, "connectors" : [ { "edgeId" : 672, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2691, "y" : 503 }, "to" : { "x" : 2668, "y" : 505 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2684, "y" : 508 }, "b" : { "x" : 2691, "y" : 503 }, "c" : { "x" : 2684, "y" : 500 }, "type" : "ARROW", "centre" : { "x" : 2684, "y" : 500 } } }, { "edgeId" : 676, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 419, "reactomeId" : 205181, "displayName" : "PTPN6:p-c-Kit complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 995, "y" : 541 }, "minX" : 965, "maxX" : 1031, "minY" : 503, "maxY" : 573, "prop" : { "x" : 965, "y" : 509, "width" : 60, "height" : 64 }, "textPosition" : { "x" : 965, "y" : 524 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1025, "y" : 509 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1025, "y" : 509 } } }, "connectors" : [ { "edgeId" : 416, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 677, "reactomeId" : 1469999, "displayName" : "p-JAK2:SFKs:p-KIT complex:p-STAT dimers", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2900, "y" : 498 }, "minX" : 2845, "maxX" : 2962, "minY" : 467, "maxY" : 523, "prop" : { "x" : 2845, "y" : 473, "width" : 111, "height" : 50 }, "textPosition" : { "x" : 2852, "y" : 474 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2956, "y" : 473 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2956, "y" : 473 } } }, "connectors" : [ { "edgeId" : 676, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 678, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 41, "reactomeId" : 211064, "displayName" : "Src family tyrosine kinases (SFKs)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2003, "y" : 636 }, "minX" : 1953, "maxX" : 2053, "minY" : 348, "maxY" : 658, "prop" : { "x" : 1953, "y" : 615, "width" : 100, "height" : 43 }, "textPosition" : { "x" : 1953, "y" : 612 }, "connectors" : [ { "edgeId" : 40, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2003, "y" : 609 }, "to" : { "x" : 2006, "y" : 348 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 42, "reactomeId" : 205271, "displayName" : "SFKs:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2127, "y" : 262 }, "minX" : 1937, "maxX" : 2760, "minY" : 227, "maxY" : 1004, "prop" : { "x" : 2085, "y" : 245, "width" : 84, "height" : 34 }, "textPosition" : { "x" : 2090, "y" : 244 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2169, "y" : 245 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2169, "y" : 245 } } }, "connectors" : [ { "edgeId" : 330, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2172, "y" : 262 }, "to" : { "x" : 2482, "y" : 267 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 459, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2135, "y" : 282 }, "to" : { "x" : 2394, "y" : 813 } }, { "from" : { "x" : 2394, "y" : 813 }, "to" : { "x" : 2760, "y" : 1004 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 395, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2172, "y" : 269 }, "to" : { "x" : 2265, "y" : 285 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 40, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 43, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2123, "y" : 282 }, "to" : { "x" : 2091, "y" : 454 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2090, "y" : 458 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2090, "y" : 458 } } }, { "edgeId" : 955, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2082, "y" : 262 }, "to" : { "x" : 1956, "y" : 263 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 955, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2082, "y" : 250 }, "to" : { "x" : 2003, "y" : 227 } }, { "from" : { "x" : 2003, "y" : 227 }, "to" : { "x" : 1944, "y" : 257 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1941, "y" : 259 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1941, "y" : 259 } } } ] }, { "id" : 44, "reactomeId" : 179838, "displayName" : "PI(3,4,5)P3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1933, "y" : 470 }, "minX" : 1836, "maxX" : 2051, "minY" : 449, "maxY" : 513, "prop" : { "x" : 1893, "y" : 450, "width" : 81, "height" : 41 }, "textPosition" : { "x" : 1895, "y" : 460 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1969, "y" : 455 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1969, "y" : 455 } } }, "connectors" : [ { "edgeId" : 43, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1977, "y" : 470 }, "to" : { "x" : 2051, "y" : 471 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 53, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1890, "y" : 487 }, "to" : { "x" : 1836, "y" : 513 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1885, "y" : 494 }, "b" : { "x" : 1890, "y" : 487 }, "c" : { "x" : 1882, "y" : 486 }, "type" : "ARROW", "centre" : { "x" : 1882, "y" : 486 } } } ] }, { "id" : 45, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2045, "y" : 396 }, "minX" : 2023, "maxX" : 2068, "minY" : 380, "maxY" : 471, "prop" : { "x" : 2023, "y" : 381, "width" : 44, "height" : 30 }, "textPosition" : { "x" : 2029, "y" : 385 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2062, "y" : 386 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2062, "y" : 386 } } }, "connectors" : [ { "edgeId" : 43, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2046, "y" : 414 }, "to" : { "x" : 2051, "y" : 471 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 2042, "y" : 436 }, "b" : { "x" : 2054, "y" : 448 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2048, "y" : 442 } } } } ] }, { "id" : 46, "reactomeId" : 195066, "displayName" : "VAV1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2034, "y" : 552 }, "minX" : 2014, "maxX" : 2061, "minY" : 471, "maxY" : 563, "prop" : { "x" : 2014, "y" : 541, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 2014, "y" : 541 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2055, "y" : 541 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2055, "y" : 541 } } }, "connectors" : [ { "edgeId" : 43, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2036, "y" : 538 }, "to" : { "x" : 2051, "y" : 471 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 47, "reactomeId" : 1433526, "displayName" : "p-VAV1:PIP3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2186, "y" : 481 }, "minX" : 2120, "maxX" : 2222, "minY" : 457, "maxY" : 721, "prop" : { "x" : 2157, "y" : 463, "width" : 59, "height" : 36 }, "textPosition" : { "x" : 2158, "y" : 464 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2216, "y" : 463 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2216, "y" : 463 } } }, "connectors" : [ { "edgeId" : 43, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2154, "y" : 476 }, "to" : { "x" : 2120, "y" : 471 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2147, "y" : 479 }, "b" : { "x" : 2154, "y" : 476 }, "c" : { "x" : 2148, "y" : 471 }, "type" : "ARROW", "centre" : { "x" : 2148, "y" : 471 } } }, { "edgeId" : 59, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2183, "y" : 502 }, "to" : { "x" : 2157, "y" : 713 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2156, "y" : 717 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2156, "y" : 717 } } } ] }, { "id" : 52, "reactomeId" : 205177, "displayName" : "PI3K:p-KIT:sSCF dimer:p-KIT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1879, "y" : 399 }, "minX" : 1826, "maxX" : 1939, "minY" : 375, "maxY" : 417, "prop" : { "x" : 1826, "y" : 381, "width" : 107, "height" : 36 }, "textPosition" : { "x" : 1827, "y" : 382 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1933, "y" : 381 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1933, "y" : 381 } } }, "connectors" : [ { "edgeId" : 50, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 54, "reactomeId" : 179856, "displayName" : "PI(4,5)P2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1750, "y" : 478 }, "minX" : 1716, "maxX" : 1790, "minY" : 461, "maxY" : 512, "prop" : { "x" : 1716, "y" : 462, "width" : 68, "height" : 33 }, "textPosition" : { "x" : 1717, "y" : 468 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1779, "y" : 467 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1779, "y" : 467 } } }, "connectors" : [ { "edgeId" : 53, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1769, "y" : 498 }, "to" : { "x" : 1790, "y" : 512 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 55, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1740, "y" : 550 }, "minX" : 1720, "maxX" : 1790, "minY" : 512, "maxY" : 565, "prop" : { "x" : 1720, "y" : 535, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1724, "y" : 539 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1755, "y" : 540 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1755, "y" : 540 } } }, "connectors" : [ { "edgeId" : 53, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1759, "y" : 532 }, "to" : { "x" : 1790, "y" : 512 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 56, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1851, "y" : 556 }, "minX" : 1831, "maxX" : 1873, "minY" : 513, "maxY" : 571, "prop" : { "x" : 1831, "y" : 541, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1835, "y" : 545 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1867, "y" : 546 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1867, "y" : 546 } } }, "connectors" : [ { "edgeId" : 53, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1845, "y" : 538 }, "to" : { "x" : 1836, "y" : 513 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1839, "y" : 533 }, "b" : { "x" : 1845, "y" : 538 }, "c" : { "x" : 1846, "y" : 530 }, "type" : "ARROW", "centre" : { "x" : 1846, "y" : 530 } } } ] }, { "id" : 60, "reactomeId" : 445010, "displayName" : "RAC1:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2062, "y" : 765 }, "minX" : 2026, "maxX" : 2109, "minY" : 729, "maxY" : 776, "prop" : { "x" : 2026, "y" : 754, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 2027, "y" : 755 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2099, "y" : 754 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2099, "y" : 754 } } }, "connectors" : [ { "edgeId" : 59, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2076, "y" : 751 }, "to" : { "x" : 2109, "y" : 729 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 61, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2064, "y" : 700 }, "minX" : 2044, "maxX" : 2109, "minY" : 684, "maxY" : 729, "prop" : { "x" : 2044, "y" : 685, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2048, "y" : 689 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2080, "y" : 690 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2080, "y" : 690 } } }, "connectors" : [ { "edgeId" : 59, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2088, "y" : 713 }, "to" : { "x" : 2109, "y" : 729 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 62, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2252, "y" : 700 }, "minX" : 2181, "maxX" : 2274, "minY" : 684, "maxY" : 729, "prop" : { "x" : 2231, "y" : 685, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 2235, "y" : 689 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2268, "y" : 690 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2268, "y" : 690 } } }, "connectors" : [ { "edgeId" : 59, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2228, "y" : 708 }, "to" : { "x" : 2181, "y" : 729 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2223, "y" : 714 }, "b" : { "x" : 2228, "y" : 708 }, "c" : { "x" : 2220, "y" : 707 }, "type" : "ARROW", "centre" : { "x" : 2220, "y" : 707 } } } ] }, { "id" : 958, "reactomeId" : 1472120, "displayName" : "SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KIT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1780, "y" : 263 }, "minX" : 1716, "maxX" : 1897, "minY" : 239, "maxY" : 281, "prop" : { "x" : 1716, "y" : 245, "width" : 129, "height" : 36 }, "textPosition" : { "x" : 1717, "y" : 246 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1845, "y" : 245 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1845, "y" : 245 } } }, "connectors" : [ { "edgeId" : 955, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1848, "y" : 263 }, "to" : { "x" : 1897, "y" : 264 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1855, "y" : 259 }, "b" : { "x" : 1848, "y" : 263 }, "c" : { "x" : 1855, "y" : 267 }, "type" : "ARROW", "centre" : { "x" : 1855, "y" : 267 } } } ] }, { "id" : 63, "reactomeId" : 442641, "displayName" : "RAC1:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2254, "y" : 765 }, "minX" : 2181, "maxX" : 2296, "minY" : 729, "maxY" : 776, "prop" : { "x" : 2218, "y" : 754, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 2220, "y" : 755 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2290, "y" : 754 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2290, "y" : 754 } } }, "connectors" : [ { "edgeId" : 59, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2231, "y" : 751 }, "to" : { "x" : 2181, "y" : 729 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2223, "y" : 752 }, "b" : { "x" : 2231, "y" : 751 }, "c" : { "x" : 2226, "y" : 745 }, "type" : "ARROW", "centre" : { "x" : 2226, "y" : 745 } } } ] }, { "id" : 1344, "reactomeId" : 9669722, "displayName" : "type II KIT binding TKIs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 349, "y" : 546 }, "isDisease" : true, "minX" : 288, "maxX" : 410, "minY" : 472, "maxY" : 564, "prop" : { "x" : 288, "y" : 528, "width" : 122, "height" : 36 }, "textPosition" : { "x" : 289, "y" : 528 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 1343, "type" : "INPUT", "segments" : [ { "from" : { "x" : 346, "y" : 522 }, "to" : { "x" : 337, "y" : 472 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1345, "reactomeId" : 9669721, "displayName" : "KIT:type II TKIs", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 461, "y" : 442 }, "minX" : 423, "maxX" : 904, "minY" : 359, "maxY" : 458, "prop" : { "x" : 423, "y" : 426, "width" : 77, "height" : 32 }, "textPosition" : { "x" : 426, "y" : 423 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 500, "y" : 426 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 500, "y" : 426 } } }, "connectors" : [ { "edgeId" : 22, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 503, "y" : 440 }, "to" : { "x" : 761, "y" : 432 } }, { "from" : { "x" : 761, "y" : 432 }, "to" : { "x" : 902, "y" : 363 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 900, "y" : 359 }, "b" : { "x" : 904, "y" : 367 }, "c" : { "x" : 902, "y" : 363 }, "type" : "STOP", "centre" : { "x" : 902, "y" : 363 } } }, { "edgeId" : 1343, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 961, "reactomeId" : 198379, "displayName" : "PI3K alpha", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1613, "y" : 790 }, "minX" : 1578, "maxX" : 3174, "minY" : 366, "maxY" : 801, "prop" : { "x" : 1578, "y" : 779, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 1592, "y" : 766 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1649, "y" : 779 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1649, "y" : 779 } } }, "connectors" : [ { "edgeId" : 1006, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1652, "y" : 790 }, "to" : { "x" : 3174, "y" : 801 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 50, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1615, "y" : 776 }, "to" : { "x" : 1724, "y" : 366 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 962, "reactomeId" : 508239, "displayName" : "GAB2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3020, "y" : 539 }, "minX" : 3000, "maxX" : 3095, "minY" : 441, "maxY" : 550, "prop" : { "x" : 3000, "y" : 528, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 3000, "y" : 528 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3041, "y" : 528 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3041, "y" : 528 } } }, "connectors" : [ { "edgeId" : 339, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3028, "y" : 525 }, "to" : { "x" : 3095, "y" : 441 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 964, "reactomeId" : 1562560, "displayName" : "p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3168, "y" : 733 }, "minX" : 3107, "maxX" : 3236, "minY" : 675, "maxY" : 801, "prop" : { "x" : 3107, "y" : 709, "width" : 123, "height" : 48 }, "textPosition" : { "x" : 3107, "y" : 708 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3230, "y" : 709 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3230, "y" : 709 } } }, "connectors" : [ { "edgeId" : 342, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3169, "y" : 706 }, "to" : { "x" : 3172, "y" : 675 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3166, "y" : 699 }, "b" : { "x" : 3169, "y" : 706 }, "c" : { "x" : 3174, "y" : 699 }, "type" : "ARROW", "centre" : { "x" : 3174, "y" : 699 } } }, { "edgeId" : 1006, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3170, "y" : 760 }, "to" : { "x" : 3174, "y" : 801 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1348, "reactomeId" : 9669711, "displayName" : "KIT:sSCF dimer:KIT:type I KIT binding TKIs:", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 898, "y" : 435 }, "minX" : 836, "maxX" : 966, "minY" : 367, "maxY" : 460, "prop" : { "x" : 836, "y" : 410, "width" : 124, "height" : 50 }, "textPosition" : { "x" : 836, "y" : 411 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 960, "y" : 410 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 960, "y" : 410 } } }, "connectors" : [ { "edgeId" : 1352, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 901, "y" : 407 }, "to" : { "x" : 908, "y" : 368 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 904, "y" : 367 }, "b" : { "x" : 912, "y" : 369 }, "c" : { "x" : 908, "y" : 368 }, "type" : "STOP", "centre" : { "x" : 908, "y" : 368 } } } ] }, { "id" : 965, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3072, "y" : 695 }, "minX" : 3052, "maxX" : 3172, "minY" : 675, "maxY" : 710, "prop" : { "x" : 3052, "y" : 680, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 3056, "y" : 684 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3088, "y" : 685 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3088, "y" : 685 } } }, "connectors" : [ { "edgeId" : 342, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3096, "y" : 690 }, "to" : { "x" : 3172, "y" : 675 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3102, "y" : 685 }, "b" : { "x" : 3096, "y" : 690 }, "c" : { "x" : 3104, "y" : 693 }, "type" : "ARROW", "centre" : { "x" : 3104, "y" : 693 } } } ] }, { "id" : 966, "reactomeId" : 74686, "displayName" : "GRB2-1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2963, "y" : 573 }, "minX" : 2935, "maxX" : 2998, "minY" : 276, "maxY" : 586, "prop" : { "x" : 2935, "y" : 561, "width" : 57, "height" : 25 }, "textPosition" : { "x" : 2937, "y" : 563 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2992, "y" : 561 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2992, "y" : 561 } } }, "connectors" : [ { "edgeId" : 348, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2964, "y" : 558 }, "to" : { "x" : 2985, "y" : 323 } }, { "from" : { "x" : 2985, "y" : 323 }, "to" : { "x" : 2962, "y" : 276 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 455, "reactomeId" : 204910, "displayName" : "SOCS1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 986, "y" : 652 }, "minX" : 959, "maxX" : 1047, "minY" : 434, "maxY" : 666, "prop" : { "x" : 959, "y" : 638, "width" : 55, "height" : 28 }, "textPosition" : { "x" : 962, "y" : 641 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1014, "y" : 638 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1014, "y" : 638 } } }, "connectors" : [ { "edgeId" : 454, "type" : "INPUT", "segments" : [ { "from" : { "x" : 998, "y" : 635 }, "to" : { "x" : 1047, "y" : 584 } }, { "from" : { "x" : 1047, "y" : 584 }, "to" : { "x" : 1031, "y" : 434 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 327, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 813, "y" : 743 }, "minX" : 767, "maxX" : 835, "minY" : 727, "maxY" : 758, "prop" : { "x" : 793, "y" : 728, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 797, "y" : 732 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 829, "y" : 733 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 829, "y" : 733 } } }, "connectors" : [ { "edgeId" : 323, "type" : "INPUT", "segments" : [ { "from" : { "x" : 790, "y" : 743 }, "to" : { "x" : 767, "y" : 743 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 72, "reactomeId" : 109797, "displayName" : "GRB2-1:SOS1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 879, "y" : 590 }, "minX" : 848, "maxX" : 916, "minY" : 537, "maxY" : 607, "prop" : { "x" : 848, "y" : 573, "width" : 62, "height" : 34 }, "textPosition" : { "x" : 850, "y" : 572 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 910, "y" : 573 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 910, "y" : 573 } } }, "connectors" : [ { "edgeId" : 71, "type" : "INPUT", "segments" : [ { "from" : { "x" : 872, "y" : 570 }, "to" : { "x" : 860, "y" : 537 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 328, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 624, "y" : 740 }, "minX" : 603, "maxX" : 683, "minY" : 724, "maxY" : 755, "prop" : { "x" : 603, "y" : 725, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 607, "y" : 729 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 640, "y" : 730 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 640, "y" : 730 } } }, "connectors" : [ { "edgeId" : 323, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 648, "y" : 740 }, "to" : { "x" : 683, "y" : 741 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 655, "y" : 736 }, "b" : { "x" : 648, "y" : 740 }, "c" : { "x" : 655, "y" : 744 }, "type" : "ARROW", "centre" : { "x" : 655, "y" : 744 } } } ] }, { "id" : 456, "reactomeId" : 1433442, "displayName" : "SOCS1:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1098, "y" : 522 }, "minX" : 1054, "maxX" : 1148, "minY" : 498, "maxY" : 540, "prop" : { "x" : 1054, "y" : 504, "width" : 88, "height" : 36 }, "textPosition" : { "x" : 1055, "y" : 505 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1142, "y" : 504 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1142, "y" : 504 } } }, "connectors" : [ { "edgeId" : 454, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 73, "reactomeId" : 205202, "displayName" : "GRB2:SOS1:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 729, "y" : 514 }, "minX" : 671, "maxX" : 793, "minY" : 490, "maxY" : 733, "prop" : { "x" : 671, "y" : 496, "width" : 116, "height" : 36 }, "textPosition" : { "x" : 671, "y" : 497 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 787, "y" : 496 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 787, "y" : 496 } } }, "connectors" : [ { "edgeId" : 323, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 728, "y" : 535 }, "to" : { "x" : 727, "y" : 725 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 727, "y" : 729 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 727, "y" : 729 } } }, { "edgeId" : 71, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1353, "reactomeId" : 9669710, "displayName" : "type I KIT binding TKIs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 543, "y" : 571 }, "isDisease" : true, "minX" : 494, "maxX" : 645, "minY" : 490, "maxY" : 593, "prop" : { "x" : 494, "y" : 549, "width" : 99, "height" : 44 }, "textPosition" : { "x" : 502, "y" : 553 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 1352, "type" : "INPUT", "segments" : [ { "from" : { "x" : 570, "y" : 543 }, "to" : { "x" : 645, "y" : 490 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 331, "reactomeId" : 162563, "displayName" : "PTPN11", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2404, "y" : 570 }, "minX" : 2374, "maxX" : 2482, "minY" : 267, "maxY" : 580, "prop" : { "x" : 2374, "y" : 560, "width" : 60, "height" : 20 }, "textPosition" : { "x" : 2376, "y" : 560 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2434, "y" : 560 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2434, "y" : 560 } } }, "connectors" : [ { "edgeId" : 330, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2408, "y" : 557 }, "to" : { "x" : 2470, "y" : 427 } }, { "from" : { "x" : 2470, "y" : 427 }, "to" : { "x" : 2482, "y" : 267 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 460, "reactomeId" : 1433305, "displayName" : "APS dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2808, "y" : 884 }, "minX" : 2760, "maxX" : 2848, "minY" : 867, "maxY" : 1004, "prop" : { "x" : 2774, "y" : 873, "width" : 68, "height" : 22 }, "textPosition" : { "x" : 2786, "y" : 860 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2842, "y" : 873 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2842, "y" : 873 } } }, "connectors" : [ { "edgeId" : 459, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2803, "y" : 898 }, "to" : { "x" : 2760, "y" : 1004 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 332, "reactomeId" : 205267, "displayName" : "SHP2:SFKs:p-KIT:sSCF dimer:p-KIT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2603, "y" : 272 }, "minX" : 2548, "maxX" : 2726, "minY" : 228, "maxY" : 290, "prop" : { "x" : 2548, "y" : 254, "width" : 111, "height" : 36 }, "textPosition" : { "x" : 2548, "y" : 255 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2659, "y" : 254 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2659, "y" : 254 } } }, "connectors" : [ { "edgeId" : 330, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 333, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2662, "y" : 270 }, "to" : { "x" : 2708, "y" : 269 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 333, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2635, "y" : 251 }, "to" : { "x" : 2682, "y" : 228 } }, { "from" : { "x" : 2682, "y" : 228 }, "to" : { "x" : 2719, "y" : 261 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2722, "y" : 264 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2722, "y" : 264 } } } ] }, { "id" : 461, "reactomeId" : 205257, "displayName" : "APS dimer:p-c-Kit:SFKs complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2637, "y" : 1007 }, "minX" : 2498, "maxX" : 2703, "minY" : 983, "maxY" : 1065, "prop" : { "x" : 2578, "y" : 989, "width" : 119, "height" : 36 }, "textPosition" : { "x" : 2579, "y" : 990 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2697, "y" : 989 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2697, "y" : 989 } } }, "connectors" : [ { "edgeId" : 459, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 464, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2575, "y" : 1012 }, "to" : { "x" : 2519, "y" : 1017 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 464, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2609, "y" : 1028 }, "to" : { "x" : 2573, "y" : 1049 } }, { "from" : { "x" : 2573, "y" : 1049 }, "to" : { "x" : 2547, "y" : 1065 } }, { "from" : { "x" : 2547, "y" : 1065 }, "to" : { "x" : 2505, "y" : 1030 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2502, "y" : 1028 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2502, "y" : 1028 } } } ] }, { "id" : 334, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2673, "y" : 345 }, "minX" : 2653, "maxX" : 2708, "minY" : 269, "maxY" : 360, "prop" : { "x" : 2653, "y" : 330, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2657, "y" : 334 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2688, "y" : 335 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2688, "y" : 335 } } }, "connectors" : [ { "edgeId" : 333, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2679, "y" : 327 }, "to" : { "x" : 2708, "y" : 269 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2687, "y" : 292 }, "b" : { "x" : 2699, "y" : 304 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2693, "y" : 298 } } } } ] }, { "id" : 335, "reactomeId" : 1433530, "displayName" : "p-SHP2:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2864, "y" : 280 }, "minX" : 2750, "maxX" : 2962, "minY" : 256, "maxY" : 298, "prop" : { "x" : 2801, "y" : 262, "width" : 126, "height" : 36 }, "textPosition" : { "x" : 2819, "y" : 263 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2927, "y" : 262 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2927, "y" : 262 } } }, "connectors" : [ { "edgeId" : 333, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2798, "y" : 274 }, "to" : { "x" : 2750, "y" : 270 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2791, "y" : 277 }, "b" : { "x" : 2798, "y" : 274 }, "c" : { "x" : 2791, "y" : 269 }, "type" : "ARROW", "centre" : { "x" : 2791, "y" : 269 } } }, { "edgeId" : 348, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2930, "y" : 277 }, "to" : { "x" : 2962, "y" : 276 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1359, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1866, "y" : 312 }, "minX" : 1846, "maxX" : 1897, "minY" : 264, "maxY" : 327, "prop" : { "x" : 1846, "y" : 297, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1850, "y" : 301 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1882, "y" : 302 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1882, "y" : 302 } } }, "connectors" : [ { "edgeId" : 955, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1875, "y" : 294 }, "to" : { "x" : 1897, "y" : 264 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1880, "y" : 273 }, "b" : { "x" : 1892, "y" : 285 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1886, "y" : 279 } } }, "endShape" : { "a" : { "x" : 1876, "y" : 286 }, "b" : { "x" : 1875, "y" : 294 }, "c" : { "x" : 1882, "y" : 291 }, "type" : "ARROW", "centre" : { "x" : 1882, "y" : 291 } } } ] }, { "id" : 336, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2811, "y" : 347 }, "minX" : 2750, "maxX" : 2833, "minY" : 270, "maxY" : 362, "prop" : { "x" : 2791, "y" : 332, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2795, "y" : 336 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2827, "y" : 337 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2827, "y" : 337 } } }, "connectors" : [ { "edgeId" : 333, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2799, "y" : 329 }, "to" : { "x" : 2750, "y" : 270 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2768, "y" : 293 }, "b" : { "x" : 2780, "y" : 305 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2774, "y" : 299 } } }, "endShape" : { "a" : { "x" : 2791, "y" : 326 }, "b" : { "x" : 2799, "y" : 329 }, "c" : { "x" : 2798, "y" : 321 }, "type" : "ARROW", "centre" : { "x" : 2798, "y" : 321 } } } ] }, { "id" : 465, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2535, "y" : 977 }, "minX" : 2515, "maxX" : 2556, "minY" : 961, "maxY" : 1017, "prop" : { "x" : 2515, "y" : 962, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2519, "y" : 966 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2550, "y" : 967 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2550, "y" : 967 } } }, "connectors" : [ { "edgeId" : 464, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2529, "y" : 995 }, "to" : { "x" : 2519, "y" : 1017 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1361, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1981, "y" : 310 }, "minX" : 1956, "maxX" : 2004, "minY" : 263, "maxY" : 325, "prop" : { "x" : 1959, "y" : 295, "width" : 44, "height" : 30 }, "textPosition" : { "x" : 1965, "y" : 299 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1998, "y" : 300 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1998, "y" : 300 } } }, "connectors" : [ { "edgeId" : 955, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1973, "y" : 292 }, "to" : { "x" : 1956, "y" : 263 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1958, "y" : 271 }, "b" : { "x" : 1970, "y" : 283 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1964, "y" : 277 } } } } ] }, { "id" : 466, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2463, "y" : 977 }, "minX" : 2443, "maxX" : 2485, "minY" : 961, "maxY" : 1020, "prop" : { "x" : 2443, "y" : 962, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2447, "y" : 966 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2479, "y" : 967 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2479, "y" : 967 } } }, "connectors" : [ { "edgeId" : 464, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2464, "y" : 995 }, "to" : { "x" : 2468, "y" : 1020 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2469, "y" : 1001 }, "b" : { "x" : 2464, "y" : 995 }, "c" : { "x" : 2461, "y" : 1002 }, "type" : "ARROW", "centre" : { "x" : 2461, "y" : 1002 } } } ] }, { "id" : 467, "reactomeId" : 1433276, "displayName" : "p-APS dimer:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2370, "y" : 1008 }, "minX" : 2308, "maxX" : 2468, "minY" : 984, "maxY" : 1026, "prop" : { "x" : 2308, "y" : 990, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 2310, "y" : 991 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2433, "y" : 990 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2433, "y" : 990 } } }, "connectors" : [ { "edgeId" : 464, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2436, "y" : 1015 }, "to" : { "x" : 2468, "y" : 1020 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2443, "y" : 1012 }, "b" : { "x" : 2436, "y" : 1015 }, "c" : { "x" : 2442, "y" : 1020 }, "type" : "ARROW", "centre" : { "x" : 2442, "y" : 1020 } } } ] }, { "id" : 1365, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2134, "y" : 397 }, "minX" : 2114, "maxX" : 2156, "minY" : 381, "maxY" : 471, "prop" : { "x" : 2114, "y" : 382, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2118, "y" : 386 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2150, "y" : 387 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2150, "y" : 387 } } }, "connectors" : [ { "edgeId" : 43, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2131, "y" : 415 }, "to" : { "x" : 2120, "y" : 471 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 2119, "y" : 437 }, "b" : { "x" : 2131, "y" : 449 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2125, "y" : 443 } } }, "endShape" : { "a" : { "x" : 2134, "y" : 423 }, "b" : { "x" : 2131, "y" : 415 }, "c" : { "x" : 2126, "y" : 421 }, "type" : "ARROW", "centre" : { "x" : 2126, "y" : 421 } } } ] }, { "id" : 471, "reactomeId" : 1433400, "displayName" : "Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2188, "y" : 1009 }, "minX" : 2098, "maxX" : 2247, "minY" : 973, "maxY" : 1034, "prop" : { "x" : 2130, "y" : 984, "width" : 117, "height" : 50 }, "textPosition" : { "x" : 2134, "y" : 984 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 470, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2124, "y" : 985 }, "to" : { "x" : 2098, "y" : 973 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 343, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2612, "y" : 559 }, "minX" : 2592, "maxX" : 2633, "minY" : 504, "maxY" : 574, "prop" : { "x" : 2592, "y" : 544, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2596, "y" : 548 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2627, "y" : 549 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2627, "y" : 549 } } }, "connectors" : [ { "edgeId" : 672, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2616, "y" : 541 }, "to" : { "x" : 2628, "y" : 504 } } ], "stoichiometry" : { "value" : 8, "shape" : { "a" : { "x" : 2616, "y" : 516 }, "b" : { "x" : 2628, "y" : 528 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2622, "y" : 522 } } } } ] }, { "id" : 1368, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3081, "y" : 568 }, "minX" : 3061, "maxX" : 3173, "minY" : 552, "maxY" : 616, "prop" : { "x" : 3061, "y" : 553, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 3065, "y" : 557 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3096, "y" : 558 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3096, "y" : 558 } } }, "connectors" : [ { "edgeId" : 342, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3104, "y" : 578 }, "to" : { "x" : 3173, "y" : 616 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 472, "reactomeId" : 112199, "displayName" : "CBL", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2163, "y" : 887 }, "minX" : 2098, "maxX" : 2184, "minY" : 870, "maxY" : 973, "prop" : { "x" : 2148, "y" : 876, "width" : 30, "height" : 22 }, "textPosition" : { "x" : 2148, "y" : 876 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2178, "y" : 876 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2178, "y" : 876 } } }, "connectors" : [ { "edgeId" : 470, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2154, "y" : 901 }, "to" : { "x" : 2098, "y" : 973 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 473, "reactomeId" : 205200, "displayName" : "CBL:Grb2/p-APS:p-c-Kit complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1978, "y" : 979 }, "minX" : 1916, "maxX" : 2047, "minY" : 955, "maxY" : 997, "prop" : { "x" : 1916, "y" : 961, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 1918, "y" : 962 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2041, "y" : 961 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2041, "y" : 961 } } }, "connectors" : [ { "edgeId" : 470, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 345, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2703, "y" : 561 }, "minX" : 2668, "maxX" : 2725, "minY" : 505, "maxY" : 576, "prop" : { "x" : 2683, "y" : 546, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2687, "y" : 550 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2719, "y" : 551 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2719, "y" : 551 } } }, "connectors" : [ { "edgeId" : 672, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2693, "y" : 543 }, "to" : { "x" : 2668, "y" : 505 } } ], "stoichiometry" : { "value" : 8, "shape" : { "a" : { "x" : 2674, "y" : 518 }, "b" : { "x" : 2686, "y" : 530 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2680, "y" : 524 } } }, "endShape" : { "a" : { "x" : 2686, "y" : 539 }, "b" : { "x" : 2693, "y" : 543 }, "c" : { "x" : 2693, "y" : 535 }, "type" : "ARROW", "centre" : { "x" : 2693, "y" : 535 } } } ] }, { "id" : 349, "reactomeId" : 1433545, "displayName" : "GAB2:GRB2:p-SHP2:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3164, "y" : 534 }, "minX" : 3121, "maxX" : 3223, "minY" : 496, "maxY" : 644, "prop" : { "x" : 3121, "y" : 502, "width" : 87, "height" : 65 }, "textPosition" : { "x" : 3120, "y" : 518 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3208, "y" : 502 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3208, "y" : 502 } } }, "connectors" : [ { "edgeId" : 339, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 342, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3167, "y" : 570 }, "to" : { "x" : 3173, "y" : 616 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 342, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3186, "y" : 570 }, "to" : { "x" : 3223, "y" : 620 } }, { "from" : { "x" : 3223, "y" : 620 }, "to" : { "x" : 3188, "y" : 639 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3185, "y" : 640 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3185, "y" : 640 } } } ] }, { "id" : 1374, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2434, "y" : 334 }, "minX" : 2352, "maxX" : 2452, "minY" : 318, "maxY" : 350, "prop" : { "x" : 2417, "y" : 319, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 2418, "y" : 323 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2446, "y" : 324 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2446, "y" : 324 } } }, "connectors" : [ { "edgeId" : 1373, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2414, "y" : 337 }, "to" : { "x" : 2352, "y" : 350 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2377, "y" : 337 }, "b" : { "x" : 2389, "y" : 349 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2383, "y" : 343 } } } } ] }, { "id" : 350, "reactomeId" : 1433549, "displayName" : "GRB2:p-SHP2:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3056, "y" : 387 }, "minX" : 3004, "maxX" : 3114, "minY" : 362, "maxY" : 441, "prop" : { "x" : 3004, "y" : 368, "width" : 104, "height" : 39 }, "textPosition" : { "x" : 3009, "y" : 372 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3108, "y" : 368 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3108, "y" : 368 } } }, "connectors" : [ { "edgeId" : 339, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3070, "y" : 410 }, "to" : { "x" : 3095, "y" : 441 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 348, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1375, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2430, "y" : 405 }, "minX" : 2357, "maxX" : 2451, "minY" : 388, "maxY" : 420, "prop" : { "x" : 2411, "y" : 390, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 2414, "y" : 394 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2445, "y" : 395 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2445, "y" : 395 } } }, "connectors" : [ { "edgeId" : 1373, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2408, "y" : 400 }, "to" : { "x" : 2357, "y" : 388 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2376, "y" : 388 }, "b" : { "x" : 2388, "y" : 400 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2382, "y" : 394 } } }, "endShape" : { "a" : { "x" : 2400, "y" : 402 }, "b" : { "x" : 2408, "y" : 400 }, "c" : { "x" : 2402, "y" : 395 }, "type" : "ARROW", "centre" : { "x" : 2402, "y" : 395 } } } ] }, { "id" : 488, "reactomeId" : 197808, "displayName" : "PTPRU", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 356, "y" : 342 }, "minX" : 332, "maxX" : 386, "minY" : 325, "maxY" : 373, "prop" : { "x" : 332, "y" : 331, "width" : 48, "height" : 22 }, "textPosition" : { "x" : 332, "y" : 331 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 380, "y" : 331 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 380, "y" : 331 } } }, "connectors" : [ { "edgeId" : 487, "type" : "INPUT", "segments" : [ { "from" : { "x" : 348, "y" : 356 }, "to" : { "x" : 336, "y" : 373 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 489, "reactomeId" : 1433419, "displayName" : "PTPRU:KIT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 212, "y" : 374 }, "minX" : 177, "maxX" : 254, "minY" : 357, "maxY" : 385, "prop" : { "x" : 177, "y" : 363, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 178, "y" : 364 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 248, "y" : 363 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 248, "y" : 363 } } }, "connectors" : [ { "edgeId" : 487, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1007, "reactomeId" : 1562561, "displayName" : "PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3174, "y" : 868 }, "minX" : 3110, "maxX" : 3245, "minY" : 830, "maxY" : 901, "prop" : { "x" : 3110, "y" : 836, "width" : 129, "height" : 65 }, "textPosition" : { "x" : 3111, "y" : 852 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3239, "y" : 836 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3239, "y" : 836 } } }, "connectors" : [ { "edgeId" : 1006, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1009, "reactomeId" : 997241, "displayName" : "SH2B3", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1415, "y" : 619 }, "minX" : 1384, "maxX" : 1453, "minY" : 384, "maxY" : 634, "prop" : { "x" : 1384, "y" : 604, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 1391, "y" : 608 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1447, "y" : 604 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1447, "y" : 604 } } }, "connectors" : [ { "edgeId" : 1008, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1415, "y" : 601 }, "to" : { "x" : 1415, "y" : 384 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1010, "reactomeId" : 1562562, "displayName" : "LNK:p-7Y-KIT:sSCF dimer:p-7Y-KIT", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1489, "y" : 443 }, "minX" : 1438, "maxX" : 1546, "minY" : 411, "maxY" : 470, "prop" : { "x" : 1438, "y" : 417, "width" : 102, "height" : 53 }, "textPosition" : { "x" : 1442, "y" : 421 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1540, "y" : 417 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1540, "y" : 417 } } }, "connectors" : [ { "edgeId" : 1008, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 1015, "reactomeId" : 1566924, "displayName" : "p-STAT dimers", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2674, "y" : 684 }, "minX" : 2625, "maxX" : 2799, "minY" : 620, "maxY" : 695, "prop" : { "x" : 2625, "y" : 673, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 2626, "y" : 674 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2723, "y" : 673 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2723, "y" : 673 } } }, "connectors" : [ { "edgeId" : 678, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2695, "y" : 670 }, "to" : { "x" : 2799, "y" : 620 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2700, "y" : 663 }, "b" : { "x" : 2695, "y" : 670 }, "c" : { "x" : 2703, "y" : 671 }, "type" : "ARROW", "centre" : { "x" : 2703, "y" : 671 } } } ] }, { "id" : 1019, "reactomeId" : 1257604, "displayName" : "PIP3 activates AKT signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1934, "y" : 724 }, "minX" : 1859, "maxX" : 2010, "minY" : 692, "maxY" : 756, "prop" : { "x" : 1859, "y" : 692, "width" : 151, "height" : 64 }, "textPosition" : { "x" : 1867, "y" : 702 }, "connectors" : [ ] }, { "id" : 767, "reactomeId" : 1469969, "displayName" : "SOCS6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1253, "y" : 624 }, "minX" : 1225, "maxX" : 1288, "minY" : 432, "maxY" : 638, "prop" : { "x" : 1225, "y" : 611, "width" : 57, "height" : 27 }, "textPosition" : { "x" : 1229, "y" : 614 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1282, "y" : 611 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1282, "y" : 611 } } }, "connectors" : [ { "edgeId" : 766, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1255, "y" : 608 }, "to" : { "x" : 1287, "y" : 432 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 1, "reactomeId" : 1433374, "displayName" : "Processing of SCF isoform 1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 203, "y" : 95 }, "minX" : 198, "maxX" : 258, "minY" : 90, "maxY" : 130, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 203, "y" : 130 }, "to" : { "x" : 203, "y" : 95 } }, { "from" : { "x" : 203, "y" : 95 }, "to" : { "x" : 258, "y" : 93 } } ], "reactionShape" : { "a" : { "x" : 197, "y" : 89 }, "b" : { "x" : 209, "y" : 101 }, "s" : "", "type" : "BOX", "empty" : true, "centre" : { "x" : 203, "y" : 95 } }, "inputs" : [ { "id" : 2 } ], "outputs" : [ { "id" : 3, "points" : [ { "x" : 331, "y" : 88 } ] }, { "id" : 4, "points" : [ { "x" : 327, "y" : 45 } ] } ], "catalysts" : [ { "id" : 5, "points" : [ { "x" : 205, "y" : 54 } ] } ] }, { "id" : 387, "reactomeId" : 205328, "displayName" : "Interaction of other tyrosine kinases with p-KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1570, "y" : 379 }, "minX" : 1538, "maxX" : 1610, "minY" : 373, "maxY" : 484, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1538, "y" : 373 }, "to" : { "x" : 1570, "y" : 379 } }, { "from" : { "x" : 1570, "y" : 379 }, "to" : { "x" : 1610, "y" : 484 } } ], "endShape" : { "a" : { "x" : 1604, "y" : 479 }, "b" : { "x" : 1610, "y" : 484 }, "c" : { "x" : 1611, "y" : 476 }, "type" : "ARROW", "centre" : { "x" : 1611, "y" : 476 } }, "reactionShape" : { "c" : { "x" : 1570, "y" : 379 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1570, "y" : 379 } }, "inputs" : [ { "id" : 24, "points" : [ { "x" : 1092, "y" : 355 } ] }, { "id" : 388, "points" : [ { "x" : 1527, "y" : 574 }, { "x" : 1562, "y" : 420 } ] } ], "outputs" : [ { "id" : 389 } ] }, { "id" : 323, "reactomeId" : 1433471, "displayName" : "Activation of RAS by p-KIT bound SOS1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 727, "y" : 741 }, "minX" : 683, "maxX" : 767, "minY" : 735, "maxY" : 747, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 767, "y" : 743 }, "to" : { "x" : 727, "y" : 741 } }, { "from" : { "x" : 727, "y" : 741 }, "to" : { "x" : 683, "y" : 741 } } ], "reactionShape" : { "a" : { "x" : 721, "y" : 735 }, "b" : { "x" : 733, "y" : 747 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 727, "y" : 741 } }, "inputs" : [ { "id" : 517, "points" : [ { "x" : 793, "y" : 687 } ] }, { "id" : 327, "points" : [ { "x" : 790, "y" : 743 } ] } ], "outputs" : [ { "id" : 521, "points" : [ { "x" : 624, "y" : 661 } ] }, { "id" : 328, "points" : [ { "x" : 648, "y" : 740 } ] } ], "catalysts" : [ { "id" : 73, "points" : [ { "x" : 728, "y" : 535 } ] } ] }, { "id" : 390, "reactomeId" : 1433501, "displayName" : "Interaction of other adapter proteins with p-KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1200, "y" : 430 }, "minX" : 1160, "maxX" : 1211, "minY" : 414, "maxY" : 459, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1160, "y" : 414 }, "to" : { "x" : 1200, "y" : 430 } }, { "from" : { "x" : 1200, "y" : 430 }, "to" : { "x" : 1211, "y" : 459 } } ], "endShape" : { "a" : { "x" : 1205, "y" : 454 }, "b" : { "x" : 1211, "y" : 459 }, "c" : { "x" : 1212, "y" : 451 }, "type" : "ARROW", "centre" : { "x" : 1212, "y" : 451 } }, "reactionShape" : { "c" : { "x" : 1200, "y" : 430 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1200, "y" : 430 } }, "inputs" : [ { "id" : 24, "points" : [ { "x" : 1073, "y" : 374 } ] }, { "id" : 391, "points" : [ { "x" : 1143, "y" : 618 } ] } ], "outputs" : [ { "id" : 392 } ] }, { "id" : 454, "reactomeId" : 1433410, "displayName" : "SOCS1 as a regulator of KIT signaling", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1079, "y" : 444 }, "minX" : 1031, "maxX" : 1093, "minY" : 434, "maxY" : 501, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1031, "y" : 434 }, "to" : { "x" : 1079, "y" : 444 } }, { "from" : { "x" : 1079, "y" : 444 }, "to" : { "x" : 1093, "y" : 501 } } ], "endShape" : { "a" : { "x" : 1087, "y" : 495 }, "b" : { "x" : 1093, "y" : 501 }, "c" : { "x" : 1095, "y" : 493 }, "type" : "ARROW", "centre" : { "x" : 1095, "y" : 493 } }, "reactionShape" : { "c" : { "x" : 1079, "y" : 444 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1079, "y" : 444 } }, "inputs" : [ { "id" : 24, "points" : [ { "x" : 1035, "y" : 374 } ] }, { "id" : 455, "points" : [ { "x" : 998, "y" : 635 }, { "x" : 1047, "y" : 584 } ] } ], "outputs" : [ { "id" : 456 } ] }, { "id" : 6, "reactomeId" : 1433395, "displayName" : "Dimerization of sSCF", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 442, "y" : 89 }, "minX" : 408, "maxX" : 470, "minY" : 84, "maxY" : 94, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 408, "y" : 87 }, "to" : { "x" : 442, "y" : 89 } }, { "from" : { "x" : 442, "y" : 89 }, "to" : { "x" : 470, "y" : 89 } } ], "endShape" : { "a" : { "x" : 463, "y" : 93 }, "b" : { "x" : 470, "y" : 89 }, "c" : { "x" : 463, "y" : 85 }, "type" : "ARROW", "centre" : { "x" : 463, "y" : 85 } }, "reactionShape" : { "c" : { "x" : 442, "y" : 89 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 442, "y" : 89 } }, "inputs" : [ { "id" : 3, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 7 } ] }, { "id" : 71, "reactomeId" : 205286, "displayName" : "GRB2:SOS interacts with p-KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 840, "y" : 533 }, "minX" : 790, "maxX" : 860, "minY" : 523, "maxY" : 538, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 860, "y" : 537 }, "to" : { "x" : 840, "y" : 533 } }, { "from" : { "x" : 840, "y" : 533 }, "to" : { "x" : 790, "y" : 523 } } ], "endShape" : { "a" : { "x" : 798, "y" : 520 }, "b" : { "x" : 790, "y" : 523 }, "c" : { "x" : 796, "y" : 528 }, "type" : "ARROW", "centre" : { "x" : 796, "y" : 528 } }, "reactionShape" : { "c" : { "x" : 840, "y" : 533 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 840, "y" : 533 } }, "inputs" : [ { "id" : 24, "points" : [ { "x" : 1027, "y" : 374 }, { "x" : 987, "y" : 443 } ] }, { "id" : 72, "points" : [ { "x" : 872, "y" : 570 } ] } ], "outputs" : [ { "id" : 73 } ] }, { "id" : 8, "reactomeId" : 205321, "displayName" : "Interaction of KIT and sSCF", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 500, "y" : 361 }, "minX" : 477, "maxX" : 530, "minY" : 356, "maxY" : 366, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 477, "y" : 361 }, "to" : { "x" : 500, "y" : 361 } }, { "from" : { "x" : 500, "y" : 361 }, "to" : { "x" : 530, "y" : 360 } } ], "endShape" : { "a" : { "x" : 523, "y" : 364 }, "b" : { "x" : 530, "y" : 360 }, "c" : { "x" : 523, "y" : 356 }, "type" : "ARROW", "centre" : { "x" : 523, "y" : 356 } }, "reactionShape" : { "c" : { "x" : 500, "y" : 361 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 500, "y" : 361 } }, "inputs" : [ { "id" : 7, "points" : [ { "x" : 507, "y" : 104 } ] }, { "id" : 10, "points" : [ { "x" : 324, "y" : 412 } ] } ], "outputs" : [ { "id" : 11 } ] }, { "id" : 1352, "reactomeId" : 9669893, "displayName" : "KIT binds type I TKIs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 724, "y" : 474 }, "minX" : 645, "maxX" : 833, "minY" : 448, "maxY" : 490, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 645, "y" : 490 }, "to" : { "x" : 724, "y" : 474 } }, { "from" : { "x" : 724, "y" : 474 }, "to" : { "x" : 833, "y" : 448 } } ], "endShape" : { "a" : { "x" : 827, "y" : 453 }, "b" : { "x" : 833, "y" : 448 }, "c" : { "x" : 825, "y" : 446 }, "type" : "ARROW", "centre" : { "x" : 825, "y" : 446 } }, "reactionShape" : { "c" : { "x" : 724, "y" : 474 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 724, "y" : 474 } }, "inputs" : [ { "id" : 1353, "points" : [ { "x" : 570, "y" : 543 } ] }, { "id" : 20, "points" : [ { "x" : 756, "y" : 373 } ] } ], "outputs" : [ { "id" : 1348 } ] }, { "id" : 330, "reactomeId" : 205238, "displayName" : "SHP2 interacts with p-KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2512, "y" : 271 }, "minX" : 2482, "maxX" : 2545, "minY" : 266, "maxY" : 276, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2482, "y" : 267 }, "to" : { "x" : 2512, "y" : 271 } }, { "from" : { "x" : 2512, "y" : 271 }, "to" : { "x" : 2545, "y" : 271 } } ], "endShape" : { "a" : { "x" : 2538, "y" : 275 }, "b" : { "x" : 2545, "y" : 271 }, "c" : { "x" : 2538, "y" : 267 }, "type" : "ARROW", "centre" : { "x" : 2538, "y" : 267 } }, "reactionShape" : { "c" : { "x" : 2512, "y" : 271 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2512, "y" : 271 } }, "inputs" : [ { "id" : 42, "points" : [ { "x" : 2172, "y" : 262 } ] }, { "id" : 331, "points" : [ { "x" : 2408, "y" : 557 }, { "x" : 2470, "y" : 427 } ] } ], "outputs" : [ { "id" : 332 } ] }, { "id" : 459, "reactomeId" : 205319, "displayName" : "Interaction of APS and p-KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2731, "y" : 1005 }, "minX" : 2700, "maxX" : 2760, "minY" : 1000, "maxY" : 1010, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2760, "y" : 1004 }, "to" : { "x" : 2731, "y" : 1005 } }, { "from" : { "x" : 2731, "y" : 1005 }, "to" : { "x" : 2700, "y" : 1005 } } ], "endShape" : { "a" : { "x" : 2707, "y" : 1001 }, "b" : { "x" : 2700, "y" : 1005 }, "c" : { "x" : 2707, "y" : 1009 }, "type" : "ARROW", "centre" : { "x" : 2707, "y" : 1009 } }, "reactionShape" : { "c" : { "x" : 2731, "y" : 1005 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2731, "y" : 1005 } }, "inputs" : [ { "id" : 42, "points" : [ { "x" : 2135, "y" : 282 }, { "x" : 2394, "y" : 813 } ] }, { "id" : 460, "points" : [ { "x" : 2803, "y" : 898 } ] } ], "outputs" : [ { "id" : 461 } ] }, { "id" : 395, "reactomeId" : 1433451, "displayName" : "JAK2 binds to p-KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2284, "y" : 286 }, "minX" : 2265, "maxX" : 2307, "minY" : 281, "maxY" : 291, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2265, "y" : 285 }, "to" : { "x" : 2284, "y" : 286 } }, { "from" : { "x" : 2284, "y" : 286 }, "to" : { "x" : 2307, "y" : 291 } } ], "endShape" : { "a" : { "x" : 2299, "y" : 293 }, "b" : { "x" : 2307, "y" : 291 }, "c" : { "x" : 2301, "y" : 286 }, "type" : "ARROW", "centre" : { "x" : 2301, "y" : 286 } }, "reactionShape" : { "c" : { "x" : 2284, "y" : 286 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2284, "y" : 286 } }, "inputs" : [ { "id" : 42, "points" : [ { "x" : 2172, "y" : 269 } ] }, { "id" : 396, "points" : [ { "x" : 2295, "y" : 532 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 397 } ] }, { "id" : 333, "reactomeId" : 1433488, "displayName" : "Phosphorylation of SHP2 by SFKs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2731, "y" : 272 }, "minX" : 2708, "maxX" : 2750, "minY" : 266, "maxY" : 278, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2708, "y" : 269 }, "to" : { "x" : 2731, "y" : 272 } }, { "from" : { "x" : 2731, "y" : 272 }, "to" : { "x" : 2750, "y" : 270 } } ], "reactionShape" : { "a" : { "x" : 2725, "y" : 266 }, "b" : { "x" : 2737, "y" : 278 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2731, "y" : 272 } }, "inputs" : [ { "id" : 334, "points" : [ { "x" : 2679, "y" : 327 } ], "stoichiometry" : 2 }, { "id" : 332, "points" : [ { "x" : 2662, "y" : 270 } ] } ], "outputs" : [ { "id" : 335, "points" : [ { "x" : 2798, "y" : 274 } ] }, { "id" : 336, "points" : [ { "x" : 2799, "y" : 329 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 332, "points" : [ { "x" : 2635, "y" : 251 }, { "x" : 2682, "y" : 228 } ] } ] }, { "id" : 1423, "reactomeId" : 9681375, "displayName" : "KIT binds ripretinib", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 462, "y" : 484 }, "isDisease" : true, "minX" : 432, "maxX" : 492, "minY" : 479, "maxY" : 489, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 432, "y" : 489 }, "to" : { "x" : 462, "y" : 484 } }, { "from" : { "x" : 462, "y" : 484 }, "to" : { "x" : 492, "y" : 484 } } ], "endShape" : { "a" : { "x" : 485, "y" : 488 }, "b" : { "x" : 492, "y" : 484 }, "c" : { "x" : 485, "y" : 480 }, "type" : "ARROW", "centre" : { "x" : 485, "y" : 480 } }, "reactionShape" : { "c" : { "x" : 462, "y" : 484 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 462, "y" : 484 } }, "inputs" : [ { "id" : 1424, "points" : [ { "x" : 454, "y" : 602 } ] }, { "id" : 10, "points" : [ { "x" : 324, "y" : 425 } ] } ], "outputs" : [ { "id" : 1425 } ] }, { "id" : 464, "reactomeId" : 1433506, "displayName" : "Phosphorylation of APS", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2493, "y" : 1020 }, "minX" : 2468, "maxX" : 2519, "minY" : 1014, "maxY" : 1026, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2519, "y" : 1017 }, "to" : { "x" : 2493, "y" : 1020 } }, { "from" : { "x" : 2493, "y" : 1020 }, "to" : { "x" : 2468, "y" : 1020 } } ], "reactionShape" : { "a" : { "x" : 2487, "y" : 1014 }, "b" : { "x" : 2499, "y" : 1026 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2493, "y" : 1020 } }, "inputs" : [ { "id" : 461, "points" : [ { "x" : 2575, "y" : 1012 } ] }, { "id" : 465, "points" : [ { "x" : 2529, "y" : 995 } ] } ], "outputs" : [ { "id" : 466, "points" : [ { "x" : 2464, "y" : 995 } ] }, { "id" : 467, "points" : [ { "x" : 2436, "y" : 1015 } ] } ], "catalysts" : [ { "id" : 461, "points" : [ { "x" : 2609, "y" : 1028 }, { "x" : 2573, "y" : 1049 }, { "x" : 2547, "y" : 1065 } ] } ] }, { "id" : 19, "reactomeId" : 205231, "displayName" : "Dimerization of KIT upon SCF binding", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 676, "y" : 359 }, "minX" : 653, "maxX" : 705, "minY" : 354, "maxY" : 364, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 653, "y" : 358 }, "to" : { "x" : 676, "y" : 359 } }, { "from" : { "x" : 676, "y" : 359 }, "to" : { "x" : 705, "y" : 359 } } ], "endShape" : { "a" : { "x" : 698, "y" : 363 }, "b" : { "x" : 705, "y" : 359 }, "c" : { "x" : 698, "y" : 355 }, "type" : "ARROW", "centre" : { "x" : 698, "y" : 355 } }, "reactionShape" : { "c" : { "x" : 676, "y" : 359 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 676, "y" : 359 } }, "inputs" : [ { "id" : 11, "points" : [ { "x" : 602, "y" : 359 } ] }, { "id" : 10, "points" : [ { "x" : 324, "y" : 416 }, { "x" : 603, "y" : 408 } ] } ], "outputs" : [ { "id" : 20 } ] }, { "id" : 339, "reactomeId" : 205234, "displayName" : "Indirect recruitment of GAB2 to p-KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3120, "y" : 442 }, "minX" : 3095, "maxX" : 3148, "minY" : 437, "maxY" : 499, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3095, "y" : 441 }, "to" : { "x" : 3120, "y" : 442 } }, { "from" : { "x" : 3120, "y" : 442 }, "to" : { "x" : 3148, "y" : 499 } } ], "endShape" : { "a" : { "x" : 3141, "y" : 495 }, "b" : { "x" : 3148, "y" : 499 }, "c" : { "x" : 3149, "y" : 491 }, "type" : "ARROW", "centre" : { "x" : 3149, "y" : 491 } }, "reactionShape" : { "c" : { "x" : 3120, "y" : 442 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3120, "y" : 442 } }, "inputs" : [ { "id" : 350, "points" : [ { "x" : 3070, "y" : 410 } ] }, { "id" : 962, "points" : [ { "x" : 3028, "y" : 525 } ] } ], "outputs" : [ { "id" : 349 } ] }, { "id" : 404, "reactomeId" : 1433456, "displayName" : "Recruitment of STATs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2543, "y" : 447 }, "minX" : 2492, "maxX" : 2548, "minY" : 442, "maxY" : 475, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2492, "y" : 450 }, "to" : { "x" : 2543, "y" : 447 } }, { "from" : { "x" : 2543, "y" : 447 }, "to" : { "x" : 2548, "y" : 475 } } ], "endShape" : { "a" : { "x" : 2543, "y" : 469 }, "b" : { "x" : 2548, "y" : 475 }, "c" : { "x" : 2551, "y" : 467 }, "type" : "ARROW", "centre" : { "x" : 2551, "y" : 467 } }, "reactionShape" : { "c" : { "x" : 2543, "y" : 447 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2543, "y" : 447 } }, "inputs" : [ { "id" : 406, "points" : [ { "x" : 2476, "y" : 555 } ], "stoichiometry" : 2 }, { "id" : 401, "points" : [ { "x" : 2416, "y" : 447 } ] } ], "outputs" : [ { "id" : 407 } ] }, { "id" : 22, "reactomeId" : 205289, "displayName" : "Autophosphorylation of KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 910, "y" : 359 }, "minX" : 870, "maxX" : 926, "minY" : 353, "maxY" : 365, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 870, "y" : 358 }, "to" : { "x" : 910, "y" : 359 } }, { "from" : { "x" : 910, "y" : 359 }, "to" : { "x" : 926, "y" : 359 } } ], "reactionShape" : { "a" : { "x" : 904, "y" : 353 }, "b" : { "x" : 916, "y" : 365 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 910, "y" : 359 } }, "inputs" : [ { "id" : 23, "points" : [ { "x" : 842, "y" : 332 } ], "stoichiometry" : 14 }, { "id" : 20, "points" : [ { "x" : 830, "y" : 358 } ] } ], "outputs" : [ { "id" : 24, "points" : [ { "x" : 983, "y" : 355 } ] }, { "id" : 25, "points" : [ { "x" : 946, "y" : 331 } ], "stoichiometry" : 14 } ], "catalysts" : [ { "id" : 20, "points" : [ { "x" : 830, "y" : 368 }, { "x" : 845, "y" : 372 } ] } ], "inhibitors" : [ { "id" : 28, "points" : [ { "x" : 114, "y" : 398 }, { "x" : 263, "y" : 293 }, { "x" : 892, "y" : 293 } ] }, { "id" : 1345, "points" : [ { "x" : 503, "y" : 440 }, { "x" : 761, "y" : 432 } ] }, { "id" : 1348, "points" : [ { "x" : 901, "y" : 407 } ] }, { "id" : 1425, "points" : [ { "x" : 621, "y" : 475 }, { "x" : 793, "y" : 449 } ] } ] }, { "id" : 342, "reactomeId" : 1433454, "displayName" : "Phosphorylation of GAB2 by SFKs", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 3174, "y" : 646 }, "minX" : 3168, "maxX" : 3180, "minY" : 616, "maxY" : 675, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3173, "y" : 616 }, "to" : { "x" : 3174, "y" : 646 } }, { "from" : { "x" : 3174, "y" : 646 }, "to" : { "x" : 3172, "y" : 675 } } ], "reactionShape" : { "a" : { "x" : 3168, "y" : 640 }, "b" : { "x" : 3180, "y" : 652 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 3174, "y" : 646 } }, "inputs" : [ { "id" : 349, "points" : [ { "x" : 3167, "y" : 570 } ] }, { "id" : 1368, "points" : [ { "x" : 3104, "y" : 578 } ] } ], "outputs" : [ { "id" : 964, "points" : [ { "x" : 3169, "y" : 706 } ] }, { "id" : 965, "points" : [ { "x" : 3096, "y" : 690 } ] } ], "catalysts" : [ { "id" : 349, "points" : [ { "x" : 3186, "y" : 570 }, { "x" : 3223, "y" : 620 } ] } ] }, { "id" : 470, "reactomeId" : 205244, "displayName" : "Recruitment of CBL to KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2070, "y" : 973 }, "minX" : 2044, "maxX" : 2098, "minY" : 968, "maxY" : 978, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2098, "y" : 973 }, "to" : { "x" : 2070, "y" : 973 } }, { "from" : { "x" : 2070, "y" : 973 }, "to" : { "x" : 2044, "y" : 974 } } ], "endShape" : { "a" : { "x" : 2051, "y" : 970 }, "b" : { "x" : 2044, "y" : 974 }, "c" : { "x" : 2051, "y" : 978 }, "type" : "ARROW", "centre" : { "x" : 2051, "y" : 978 } }, "reactionShape" : { "c" : { "x" : 2070, "y" : 973 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2070, "y" : 973 } }, "inputs" : [ { "id" : 471, "points" : [ { "x" : 2124, "y" : 985 } ] }, { "id" : 472, "points" : [ { "x" : 2154, "y" : 901 } ] } ], "outputs" : [ { "id" : 473 } ] }, { "id" : 348, "reactomeId" : 1433428, "displayName" : "GRB2 is indirectly recruited to p-KIT through SHP2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2995, "y" : 277 }, "minX" : 2962, "maxX" : 3045, "minY" : 272, "maxY" : 365, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2962, "y" : 276 }, "to" : { "x" : 2995, "y" : 277 } }, { "from" : { "x" : 2995, "y" : 277 }, "to" : { "x" : 3045, "y" : 365 } } ], "endShape" : { "a" : { "x" : 3038, "y" : 361 }, "b" : { "x" : 3045, "y" : 365 }, "c" : { "x" : 3045, "y" : 357 }, "type" : "ARROW", "centre" : { "x" : 3045, "y" : 357 } }, "reactionShape" : { "c" : { "x" : 2995, "y" : 277 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2995, "y" : 277 } }, "inputs" : [ { "id" : 335, "points" : [ { "x" : 2930, "y" : 277 } ] }, { "id" : 966, "points" : [ { "x" : 2964, "y" : 558 }, { "x" : 2985, "y" : 323 } ] } ], "outputs" : [ { "id" : 350 } ] }, { "id" : 412, "reactomeId" : 1433508, "displayName" : "PKC alpha interacts with and phosphorylates KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 198, "y" : 418 }, "minX" : 175, "maxX" : 240, "minY" : 412, "maxY" : 424, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 240, "y" : 415 }, "to" : { "x" : 198, "y" : 418 } }, { "from" : { "x" : 198, "y" : 418 }, "to" : { "x" : 175, "y" : 417 } } ], "reactionShape" : { "a" : { "x" : 192, "y" : 412 }, "b" : { "x" : 204, "y" : 424 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 198, "y" : 418 } }, "inputs" : [ { "id" : 10, "points" : [ { "x" : 290, "y" : 416 } ] }, { "id" : 413, "points" : [ { "x" : 205, "y" : 553 } ] }, { "id" : 769, "points" : [ { "x" : 259, "y" : 556 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 28, "points" : [ { "x" : 152, "y" : 417 } ] }, { "id" : 770, "points" : [ { "x" : 136, "y" : 556 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 413, "points" : [ { "x" : 201, "y" : 553 } ] } ] }, { "id" : 1373, "reactomeId" : 1433418, "displayName" : "Phosphorylation of JAK2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2354, "y" : 371 }, "minX" : 2348, "maxX" : 2360, "minY" : 350, "maxY" : 388, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2352, "y" : 350 }, "to" : { "x" : 2354, "y" : 371 } }, { "from" : { "x" : 2354, "y" : 371 }, "to" : { "x" : 2357, "y" : 388 } } ], "reactionShape" : { "a" : { "x" : 2348, "y" : 365 }, "b" : { "x" : 2360, "y" : 377 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2354, "y" : 371 } }, "inputs" : [ { "id" : 397, "points" : [ { "x" : 2355, "y" : 323 } ] }, { "id" : 1374, "points" : [ { "x" : 2414, "y" : 337 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 1375, "points" : [ { "x" : 2408, "y" : 400 } ], "stoichiometry" : 2 }, { "id" : 401, "points" : [ { "x" : 2360, "y" : 425 } ] } ], "catalysts" : [ { "id" : 397, "points" : [ { "x" : 2335, "y" : 323 }, { "x" : 2313, "y" : 339 } ] } ] }, { "id" : 672, "reactomeId" : 1470009, "displayName" : "Phosphorylation of STATs", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2650, "y" : 503 }, "minX" : 2628, "maxX" : 2668, "minY" : 497, "maxY" : 509, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2628, "y" : 504 }, "to" : { "x" : 2650, "y" : 503 } }, { "from" : { "x" : 2650, "y" : 503 }, "to" : { "x" : 2668, "y" : 505 } } ], "reactionShape" : { "a" : { "x" : 2644, "y" : 497 }, "b" : { "x" : 2656, "y" : 509 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2650, "y" : 503 } }, "inputs" : [ { "id" : 407, "points" : [ { "x" : 2607, "y" : 503 } ] }, { "id" : 343, "points" : [ { "x" : 2616, "y" : 541 } ], "stoichiometry" : 8 } ], "outputs" : [ { "id" : 675, "points" : [ { "x" : 2691, "y" : 503 } ] }, { "id" : 345, "points" : [ { "x" : 2693, "y" : 543 } ], "stoichiometry" : 8 } ], "catalysts" : [ { "id" : 407, "points" : [ { "x" : 2589, "y" : 475 }, { "x" : 2639, "y" : 447 } ] } ] }, { "id" : 416, "reactomeId" : 205306, "displayName" : "Interaction of SHP1 and KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 985, "y" : 486 }, "minX" : 955, "maxX" : 990, "minY" : 481, "maxY" : 506, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 955, "y" : 490 }, "to" : { "x" : 985, "y" : 486 } }, { "from" : { "x" : 985, "y" : 486 }, "to" : { "x" : 989, "y" : 506 } } ], "endShape" : { "a" : { "x" : 984, "y" : 500 }, "b" : { "x" : 989, "y" : 506 }, "c" : { "x" : 992, "y" : 498 }, "type" : "ARROW", "centre" : { "x" : 992, "y" : 498 } }, "reactionShape" : { "c" : { "x" : 985, "y" : 486 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 985, "y" : 486 } }, "inputs" : [ { "id" : 24, "points" : [ { "x" : 1031, "y" : 374 }, { "x" : 1012, "y" : 428 } ] }, { "id" : 417, "points" : [ { "x" : 915, "y" : 541 } ] } ], "outputs" : [ { "id" : 419 } ] }, { "id" : 676, "reactomeId" : 1470010, "displayName" : "Dimerization of STATs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2819, "y" : 501 }, "minX" : 2807, "maxX" : 2842, "minY" : 496, "maxY" : 506, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2807, "y" : 500 }, "to" : { "x" : 2819, "y" : 501 } }, { "from" : { "x" : 2819, "y" : 501 }, "to" : { "x" : 2842, "y" : 500 } } ], "endShape" : { "a" : { "x" : 2835, "y" : 504 }, "b" : { "x" : 2842, "y" : 500 }, "c" : { "x" : 2835, "y" : 496 }, "type" : "ARROW", "centre" : { "x" : 2835, "y" : 496 } }, "reactionShape" : { "a" : { "x" : 2813, "y" : 495 }, "b" : { "x" : 2825, "y" : 507 }, "s" : "", "type" : "BOX", "empty" : true, "centre" : { "x" : 2819, "y" : 501 } }, "inputs" : [ { "id" : 675 } ], "outputs" : [ { "id" : 677 } ] }, { "id" : 678, "reactomeId" : 1470012, "displayName" : "Disassociation and translocation of STATs to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2865, "y" : 620 }, "minX" : 2799, "maxX" : 2892, "minY" : 526, "maxY" : 625, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 2892, "y" : 526 }, "to" : { "x" : 2865, "y" : 620 } }, { "from" : { "x" : 2865, "y" : 620 }, "to" : { "x" : 2799, "y" : 620 } } ], "reactionShape" : { "c" : { "x" : 2865, "y" : 620 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 2865, "y" : 620 } }, "inputs" : [ { "id" : 677 } ], "outputs" : [ { "id" : 401, "points" : [ { "x" : 2363, "y" : 468 }, { "x" : 2372, "y" : 615 } ] }, { "id" : 1015, "points" : [ { "x" : 2695, "y" : 670 } ] } ] }, { "id" : 487, "reactomeId" : 1433423, "displayName" : "PTP-RO interacts with p-c-Kit complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 305, "y" : 373 }, "minX" : 251, "maxX" : 336, "minY" : 368, "maxY" : 378, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 336, "y" : 373 }, "to" : { "x" : 305, "y" : 373 } }, { "from" : { "x" : 305, "y" : 373 }, "to" : { "x" : 251, "y" : 373 } } ], "endShape" : { "a" : { "x" : 258, "y" : 369 }, "b" : { "x" : 251, "y" : 373 }, "c" : { "x" : 258, "y" : 377 }, "type" : "ARROW", "centre" : { "x" : 258, "y" : 377 } }, "reactionShape" : { "c" : { "x" : 305, "y" : 373 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 305, "y" : 373 } }, "inputs" : [ { "id" : 488, "points" : [ { "x" : 348, "y" : 356 } ] }, { "id" : 10, "points" : [ { "x" : 314, "y" : 403 } ] } ], "outputs" : [ { "id" : 489 } ] }, { "id" : 40, "reactomeId" : 205205, "displayName" : "Interaction of Src family kinases with p-KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2026, "y" : 338 }, "minX" : 2006, "maxX" : 2104, "minY" : 282, "maxY" : 348, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2006, "y" : 348 }, "to" : { "x" : 2026, "y" : 338 } }, { "from" : { "x" : 2026, "y" : 338 }, "to" : { "x" : 2104, "y" : 282 } } ], "endShape" : { "a" : { "x" : 2101, "y" : 289 }, "b" : { "x" : 2104, "y" : 282 }, "c" : { "x" : 2096, "y" : 283 }, "type" : "ARROW", "centre" : { "x" : 2096, "y" : 283 } }, "reactionShape" : { "c" : { "x" : 2026, "y" : 338 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2026, "y" : 338 } }, "inputs" : [ { "id" : 41, "points" : [ { "x" : 2003, "y" : 609 } ] }, { "id" : 24, "points" : [ { "x" : 1092, "y" : 352 } ] } ], "outputs" : [ { "id" : 42 } ] }, { "id" : 43, "reactomeId" : 1433542, "displayName" : "Phosphorylation and activation of VAV1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2088, "y" : 470 }, "minX" : 2051, "maxX" : 2120, "minY" : 464, "maxY" : 476, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2051, "y" : 471 }, "to" : { "x" : 2088, "y" : 470 } }, { "from" : { "x" : 2088, "y" : 470 }, "to" : { "x" : 2120, "y" : 471 } } ], "reactionShape" : { "a" : { "x" : 2082, "y" : 464 }, "b" : { "x" : 2094, "y" : 476 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2088, "y" : 470 } }, "inputs" : [ { "id" : 44, "points" : [ { "x" : 1977, "y" : 470 } ] }, { "id" : 45, "points" : [ { "x" : 2046, "y" : 414 } ], "stoichiometry" : 3 }, { "id" : 46, "points" : [ { "x" : 2036, "y" : 538 } ] } ], "outputs" : [ { "id" : 47, "points" : [ { "x" : 2154, "y" : 476 } ] }, { "id" : 1365, "points" : [ { "x" : 2131, "y" : 415 } ], "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 42, "points" : [ { "x" : 2123, "y" : 282 } ] } ] }, { "id" : 1006, "reactomeId" : 1562641, "displayName" : "Indirect recruitment of PI3K to KIT via p(Y)-GAB2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3173, "y" : 812 }, "minX" : 3168, "maxX" : 3178, "minY" : 801, "maxY" : 833, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3174, "y" : 801 }, "to" : { "x" : 3173, "y" : 812 } }, { "from" : { "x" : 3173, "y" : 812 }, "to" : { "x" : 3173, "y" : 833 } } ], "endShape" : { "a" : { "x" : 3169, "y" : 826 }, "b" : { "x" : 3173, "y" : 833 }, "c" : { "x" : 3177, "y" : 826 }, "type" : "ARROW", "centre" : { "x" : 3177, "y" : 826 } }, "reactionShape" : { "c" : { "x" : 3173, "y" : 812 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3173, "y" : 812 } }, "inputs" : [ { "id" : 961, "points" : [ { "x" : 1652, "y" : 790 } ] }, { "id" : 964, "points" : [ { "x" : 3170, "y" : 760 } ] } ], "outputs" : [ { "id" : 1007 } ] }, { "id" : 1008, "reactomeId" : 1562640, "displayName" : "LNK binds to p-KIT and inhibit downstream signaling", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1466, "y" : 385 }, "minX" : 1415, "maxX" : 1478, "minY" : 380, "maxY" : 414, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1415, "y" : 384 }, "to" : { "x" : 1466, "y" : 385 } }, { "from" : { "x" : 1466, "y" : 385 }, "to" : { "x" : 1478, "y" : 414 } } ], "endShape" : { "a" : { "x" : 1472, "y" : 409 }, "b" : { "x" : 1478, "y" : 414 }, "c" : { "x" : 1479, "y" : 406 }, "type" : "ARROW", "centre" : { "x" : 1479, "y" : 406 } }, "reactionShape" : { "c" : { "x" : 1466, "y" : 385 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1466, "y" : 385 } }, "inputs" : [ { "id" : 1009, "points" : [ { "x" : 1415, "y" : 601 } ] }, { "id" : 24, "points" : [ { "x" : 1092, "y" : 357 } ] } ], "outputs" : [ { "id" : 1010 } ] }, { "id" : 50, "reactomeId" : 205262, "displayName" : "Direct recruitment of PI3K to p-KIT", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1787, "y" : 378 }, "minX" : 1724, "maxX" : 1823, "minY" : 366, "maxY" : 386, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1724, "y" : 366 }, "to" : { "x" : 1787, "y" : 378 } }, { "from" : { "x" : 1787, "y" : 378 }, "to" : { "x" : 1823, "y" : 386 } } ], "endShape" : { "a" : { "x" : 1815, "y" : 388 }, "b" : { "x" : 1823, "y" : 386 }, "c" : { "x" : 1817, "y" : 381 }, "type" : "ARROW", "centre" : { "x" : 1817, "y" : 381 } }, "reactionShape" : { "c" : { "x" : 1787, "y" : 378 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1787, "y" : 378 } }, "inputs" : [ { "id" : 24, "points" : [ { "x" : 1092, "y" : 353 } ] }, { "id" : 961, "points" : [ { "x" : 1615, "y" : 776 } ] } ], "outputs" : [ { "id" : 52 } ] }, { "id" : 53, "reactomeId" : 1433514, "displayName" : "Synthesis of PIP3 from PIP2 by PI3K", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1812, "y" : 513 }, "minX" : 1790, "maxX" : 1836, "minY" : 507, "maxY" : 519, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1790, "y" : 512 }, "to" : { "x" : 1812, "y" : 513 } }, { "from" : { "x" : 1812, "y" : 513 }, "to" : { "x" : 1836, "y" : 513 } } ], "reactionShape" : { "a" : { "x" : 1806, "y" : 507 }, "b" : { "x" : 1818, "y" : 519 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1812, "y" : 513 } }, "inputs" : [ { "id" : 54, "points" : [ { "x" : 1769, "y" : 498 } ] }, { "id" : 55, "points" : [ { "x" : 1759, "y" : 532 } ] } ], "outputs" : [ { "id" : 44, "points" : [ { "x" : 1890, "y" : 487 } ] }, { "id" : 56, "points" : [ { "x" : 1845, "y" : 538 } ] } ], "catalysts" : [ { "id" : 1027, "points" : [ { "x" : 1798, "y" : 872 } ] } ] }, { "id" : 59, "reactomeId" : 1433415, "displayName" : "Activation of RAC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2155, "y" : 729 }, "minX" : 2109, "maxX" : 2181, "minY" : 723, "maxY" : 735, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2109, "y" : 729 }, "to" : { "x" : 2155, "y" : 729 } }, { "from" : { "x" : 2155, "y" : 729 }, "to" : { "x" : 2181, "y" : 729 } } ], "reactionShape" : { "a" : { "x" : 2149, "y" : 723 }, "b" : { "x" : 2161, "y" : 735 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2155, "y" : 729 } }, "inputs" : [ { "id" : 60, "points" : [ { "x" : 2076, "y" : 751 } ] }, { "id" : 61, "points" : [ { "x" : 2088, "y" : 713 } ] } ], "outputs" : [ { "id" : 62, "points" : [ { "x" : 2228, "y" : 708 } ] }, { "id" : 63, "points" : [ { "x" : 2231, "y" : 751 } ] } ], "catalysts" : [ { "id" : 47, "points" : [ { "x" : 2183, "y" : 502 } ] } ] }, { "id" : 955, "reactomeId" : 1472121, "displayName" : "Phosphorylation of p-KIT on Y900 by Src kinases", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1930, "y" : 264 }, "minX" : 1897, "maxX" : 1956, "minY" : 258, "maxY" : 270, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1956, "y" : 263 }, "to" : { "x" : 1930, "y" : 264 } }, { "from" : { "x" : 1930, "y" : 264 }, "to" : { "x" : 1897, "y" : 264 } } ], "reactionShape" : { "a" : { "x" : 1924, "y" : 258 }, "b" : { "x" : 1936, "y" : 270 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1930, "y" : 264 } }, "inputs" : [ { "id" : 42, "points" : [ { "x" : 2082, "y" : 262 } ] }, { "id" : 1361, "points" : [ { "x" : 1973, "y" : 292 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 958, "points" : [ { "x" : 1848, "y" : 263 } ] }, { "id" : 1359, "points" : [ { "x" : 1875, "y" : 294 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 42, "points" : [ { "x" : 2082, "y" : 250 }, { "x" : 2003, "y" : 227 } ] } ] }, { "id" : 766, "reactomeId" : 1470011, "displayName" : "Downregulation of c-Kit signaling by SOCS6", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1300, "y" : 436 }, "minX" : 1287, "maxX" : 1338, "minY" : 431, "maxY" : 516, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1287, "y" : 432 }, "to" : { "x" : 1300, "y" : 436 } }, { "from" : { "x" : 1300, "y" : 436 }, "to" : { "x" : 1338, "y" : 516 } } ], "endShape" : { "a" : { "x" : 1331, "y" : 511 }, "b" : { "x" : 1338, "y" : 516 }, "c" : { "x" : 1339, "y" : 508 }, "type" : "ARROW", "centre" : { "x" : 1339, "y" : 508 } }, "reactionShape" : { "c" : { "x" : 1300, "y" : 436 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1300, "y" : 436 } }, "inputs" : [ { "id" : 767, "points" : [ { "x" : 1255, "y" : 608 } ] }, { "id" : 24, "points" : [ { "x" : 1092, "y" : 369 } ] } ], "outputs" : [ { "id" : 768 } ] }, { "id" : 1343, "reactomeId" : 9669854, "displayName" : "KIT binds type II TKIs", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 378, "y" : 437 }, "minX" : 337, "maxX" : 420, "minY" : 432, "maxY" : 472, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 337, "y" : 472 }, "to" : { "x" : 378, "y" : 437 } }, { "from" : { "x" : 378, "y" : 437 }, "to" : { "x" : 420, "y" : 439 } } ], "endShape" : { "a" : { "x" : 413, "y" : 443 }, "b" : { "x" : 420, "y" : 439 }, "c" : { "x" : 413, "y" : 435 }, "type" : "ARROW", "centre" : { "x" : 413, "y" : 435 } }, "reactionShape" : { "c" : { "x" : 378, "y" : 437 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 378, "y" : 437 } }, "inputs" : [ { "id" : 1344, "points" : [ { "x" : 346, "y" : 522 } ] }, { "id" : 10, "points" : [ { "x" : 313, "y" : 431 } ] } ], "outputs" : [ { "id" : 1345 } ] } ], "compartments" : [ { "id" : 680, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2668, "y" : 704 }, "minX" : 2579, "maxX" : 2758, "minY" : 641, "maxY" : 767, "prop" : { "x" : 2579, "y" : 641, "width" : 179, "height" : 126 }, "textPosition" : { "x" : 2591, "y" : 716 }, "insets" : { "x" : 2588, "y" : 649, "width" : 161, "height" : 110 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 1015 ] }, { "id" : 668, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1681, "y" : 585 }, "minX" : 0, "maxX" : 3362, "minY" : 122, "maxY" : 1048, "prop" : { "x" : 0, "y" : 122, "width" : 3362, "height" : 926 }, "textPosition" : { "x" : 1158, "y" : 709 }, "insets" : { "x" : 93, "y" : 519, "width" : 3060, "height" : 386 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 2, 10, 11, 20, 23, 25, 28, 72, 73, 327, 328, 349, 350, 388, 413, 417, 455, 456, 488, 489, 517, 521, 8, 19, 22, 71, 323, 348, 412, 416, 454, 487, 24, 41, 52, 54, 55, 389, 391, 392, 396, 50, 387, 390, 42, 44, 45, 46, 47, 56, 60, 61, 62, 63, 331, 332, 335, 406, 407, 43, 53, 59, 330, 333, 339, 404, 461, 467, 471, 472, 473, 459, 464, 470, 672, 675, 676, 677, 678, 680, 336, 343, 345, 460, 465, 466, 766, 767, 768, 770, 769, 955, 958, 961, 962, 964, 966, 965, 342, 1006, 1007, 1008, 1009, 1010, 1019, 1020, 1022, 1024, 1026, 1027, 1029, 1028, 1195, 1197, 1198, 1343, 1344, 1345, 1348, 1352, 1353, 419, 1023, 40, 1359, 1361, 1365, 395, 397, 401, 1368, 334, 1373, 1374, 1375, 1202, 1205, 1206, 1207, 1405, 1407, 1412, 1415, 1413, 1414, 1416, 1419, 1423, 1424, 1425 ] } ], "notes" : [ ], "links" : [ { "id" : 1026, "renderableClass" : "Interaction", "position" : { "x" : 516, "y" : 708 }, "minX" : 510, "maxX" : 598, "minY" : 661, "maxY" : 748, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 598, "y" : 661 }, "to" : { "x" : 516, "y" : 708 } }, { "from" : { "x" : 516, "y" : 708 }, "to" : { "x" : 513, "y" : 748 } } ], "endShape" : { "a" : { "x" : 510, "y" : 741 }, "b" : { "x" : 513, "y" : 748 }, "c" : { "x" : 518, "y" : 741 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 518, "y" : 741 } }, "reactionShape" : { "a" : { "x" : 510, "y" : 702 }, "b" : { "x" : 522, "y" : 714 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 516, "y" : 708 } }, "inputs" : [ { "id" : 521 } ], "outputs" : [ { "id" : 1024 } ] }, { "id" : 1028, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 2214, "y" : 865 }, "minX" : 1897, "maxX" : 3107, "minY" : 859, "maxY" : 886, "segments" : [ { "from" : { "x" : 3107, "y" : 867 }, "to" : { "x" : 2463, "y" : 862 } }, { "from" : { "x" : 2463, "y" : 862 }, "to" : { "x" : 1965, "y" : 869 } }, { "from" : { "x" : 1965, "y" : 869 }, "to" : { "x" : 1897, "y" : 886 } } ], "reactionShape" : { "a" : { "x" : 2208, "y" : 859 }, "b" : { "x" : 2220, "y" : 871 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2214, "y" : 865 } }, "inputs" : [ { "id" : 1007 } ], "outputs" : [ { "id" : 1027 } ] }, { "id" : 1029, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1877, "y" : 596 }, "minX" : 1804, "maxX" : 1883, "minY" : 420, "maxY" : 872, "segments" : [ { "from" : { "x" : 1878, "y" : 420 }, "to" : { "x" : 1877, "y" : 596 } }, { "from" : { "x" : 1877, "y" : 596 }, "to" : { "x" : 1804, "y" : 872 } } ], "reactionShape" : { "a" : { "x" : 1871, "y" : 590 }, "b" : { "x" : 1883, "y" : 602 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1877, "y" : 596 } }, "inputs" : [ { "id" : 52 } ], "outputs" : [ { "id" : 1027 } ] }, { "id" : 1020, "renderableClass" : "Interaction", "position" : { "x" : 1933, "y" : 591 }, "minX" : 1927, "maxX" : 1939, "minY" : 494, "maxY" : 689, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1933, "y" : 494 }, "to" : { "x" : 1933, "y" : 689 } } ], "endShape" : { "a" : { "x" : 1929, "y" : 682 }, "b" : { "x" : 1933, "y" : 689 }, "c" : { "x" : 1937, "y" : 682 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1937, "y" : 682 } }, "reactionShape" : { "a" : { "x" : 1927, "y" : 585 }, "b" : { "x" : 1939, "y" : 597 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1933, "y" : 591 } }, "inputs" : [ { "id" : 44 } ], "outputs" : [ { "id" : 1019 } ] }, { "id" : 1022, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 955, "y" : 831 }, "minX" : 751, "maxX" : 2124, "minY" : 535, "maxY" : 1015, "segments" : [ { "from" : { "x" : 751, "y" : 535 }, "to" : { "x" : 897, "y" : 647 } }, { "from" : { "x" : 897, "y" : 647 }, "to" : { "x" : 1014, "y" : 1015 } }, { "from" : { "x" : 1014, "y" : 1015 }, "to" : { "x" : 2124, "y" : 1009 } } ], "reactionShape" : { "a" : { "x" : 949, "y" : 825 }, "b" : { "x" : 961, "y" : 837 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 955, "y" : 831 } }, "inputs" : [ { "id" : 73 } ], "outputs" : [ { "id" : 471 } ] }, { "id" : 1023, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 2279, "y" : 1008 }, "minX" : 2253, "maxX" : 2305, "minY" : 1002, "maxY" : 1014, "segments" : [ { "from" : { "x" : 2305, "y" : 1008 }, "to" : { "x" : 2253, "y" : 1008 } } ], "reactionShape" : { "a" : { "x" : 2273, "y" : 1002 }, "b" : { "x" : 2285, "y" : 1014 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2279, "y" : 1008 } }, "inputs" : [ { "id" : 467 } ], "outputs" : [ { "id" : 471 } ] } ], "shadows" : [ { "id" : 1426, "reactomeId" : 1433559, "displayName" : "Regulation of KIT signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1437, "y" : 639 }, "minX" : 22, "maxX" : 2852, "minY" : 235, "maxY" : 1044, "prop" : { "x" : 22, "y" : 235, "width" : 2830, "height" : 809 }, "points" : [ { "x" : 22, "y" : 235 }, { "x" : 2852, "y" : 235 }, { "x" : 2852, "y" : 1044 }, { "x" : 22, "y" : 1044 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 3362, "minY" : 0, "maxY" : 1065, "disease" : true }