{
  "dbId" : 1257604,
  "stableId" : "R-HSA-1257604",
  "displayName" : "PIP3 activates AKT signaling",
  "forNormalDraw" : true,
  "nodes" : [ {
    "id" : 1796,
    "reactomeId" : 199420,
    "displayName" : "PTEN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 542,
      "y" : 381
    },
    "minX" : 482,
    "maxX" : 577,
    "minY" : 364,
    "maxY" : 393,
    "prop" : {
      "x" : 513,
      "y" : 370,
      "width" : 58,
      "height" : 23
    },
    "textPosition" : {
      "x" : 522,
      "y" : 371
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 571,
          "y" : 370
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 571,
          "y" : 370
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 377,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 510,
          "y" : 382
        },
        "to" : {
          "x" : 490,
          "y" : 383
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 486,
          "y" : 383
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 486,
          "y" : 383
        }
      }
    } ]
  }, {
    "id" : 1546,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1863,
      "y" : 1167
    },
    "minX" : 1802,
    "maxX" : 1886,
    "minY" : 1153,
    "maxY" : 1207,
    "prop" : {
      "x" : 1841,
      "y" : 1154,
      "width" : 44,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1846,
      "y" : 1157
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1880,
          "y" : 1159
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1880,
          "y" : 1159
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1545,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1842,
          "y" : 1184
        },
        "to" : {
          "x" : 1802,
          "y" : 1207
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1816,
            "y" : 1189
          },
          "b" : {
            "x" : 1828,
            "y" : 1201
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1822,
            "y" : 1195
          }
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 1547,
    "reactomeId" : 198356,
    "displayName" : "p-T308,S473-AKT1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1750,
      "y" : 1167
    },
    "minX" : 1689,
    "maxX" : 1818,
    "minY" : 1142,
    "maxY" : 1207,
    "prop" : {
      "x" : 1689,
      "y" : 1148,
      "width" : 123,
      "height" : 38
    },
    "innerProp" : {
      "x" : 1689,
      "y" : 1154,
      "width" : 123,
      "height" : 32
    },
    "textPosition" : {
      "x" : 1690,
      "y" : 1156
    },
    "nodeAttachments" : [ {
      "reactomeId" : 198329,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 308",
      "shape" : {
        "a" : {
          "x" : 1698,
          "y" : 1142
        },
        "b" : {
          "x" : 1710,
          "y" : 1154
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1704,
          "y" : 1148
        }
      }
    }, {
      "reactomeId" : 198374,
      "label" : "P",
      "description" : "O-phospho-L-serine at 473",
      "shape" : {
        "a" : {
          "x" : 1714,
          "y" : 1142
        },
        "b" : {
          "x" : 1726,
          "y" : 1154
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1720,
          "y" : 1148
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1812,
          "y" : 1148
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1812,
          "y" : 1148
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1545,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1774,
          "y" : 1189
        },
        "to" : {
          "x" : 1802,
          "y" : 1207
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1549,
    "reactomeId" : 58252,
    "displayName" : "AKT1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1783,
      "y" : 1388
    },
    "minX" : 1753,
    "maxX" : 1819,
    "minY" : 1319,
    "maxY" : 1400,
    "prop" : {
      "x" : 1753,
      "y" : 1377,
      "width" : 60,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1764,
      "y" : 1378
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1813,
          "y" : 1377
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1813,
          "y" : 1377
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1545,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1786,
          "y" : 1374
        },
        "to" : {
          "x" : 1803,
          "y" : 1319
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1784,
          "y" : 1366
        },
        "b" : {
          "x" : 1786,
          "y" : 1374
        },
        "c" : {
          "x" : 1792,
          "y" : 1369
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1792,
          "y" : 1369
        }
      }
    } ]
  }, {
    "id" : 1551,
    "reactomeId" : 6811526,
    "displayName" : "PP2A-B56-beta,gamma",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1916,
      "y" : 1250
    },
    "minX" : 1811,
    "maxX" : 2034,
    "minY" : 1226,
    "maxY" : 1268,
    "prop" : {
      "x" : 1866,
      "y" : 1232,
      "width" : 100,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1872,
      "y" : 1233
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1966,
          "y" : 1232
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1966,
          "y" : 1232
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1545,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1863,
          "y" : 1251
        },
        "to" : {
          "x" : 1819,
          "y" : 1253
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1815,
          "y" : 1253
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1815,
          "y" : 1253
        }
      }
    }, {
      "edgeId" : 1556,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1969,
          "y" : 1257
        },
        "to" : {
          "x" : 2034,
          "y" : 1268
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 784,
    "reactomeId" : 2400007,
    "displayName" : "THEM4/TRIB3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 569,
      "y" : 111
    },
    "minX" : 541,
    "maxX" : 598,
    "minY" : 66,
    "maxY" : 129,
    "prop" : {
      "x" : 541,
      "y" : 93,
      "width" : 57,
      "height" : 36
    },
    "textPosition" : {
      "x" : 542,
      "y" : 93
    },
    "connectors" : [ {
      "edgeId" : 376,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 575,
          "y" : 87
        },
        "to" : {
          "x" : 586,
          "y" : 66
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1553,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1856,
      "y" : 1388
    },
    "minX" : 1803,
    "maxX" : 1876,
    "minY" : 1319,
    "maxY" : 1401,
    "prop" : {
      "x" : 1838,
      "y" : 1375,
      "width" : 37,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1847,
      "y" : 1377
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1870,
          "y" : 1380
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1870,
          "y" : 1380
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1545,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1846,
          "y" : 1372
        },
        "to" : {
          "x" : 1803,
          "y" : 1319
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1818,
            "y" : 1339
          },
          "b" : {
            "x" : 1830,
            "y" : 1351
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1824,
            "y" : 1345
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1839,
          "y" : 1369
        },
        "b" : {
          "x" : 1846,
          "y" : 1372
        },
        "c" : {
          "x" : 1845,
          "y" : 1364
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1845,
          "y" : 1364
        }
      }
    } ]
  }, {
    "id" : 786,
    "reactomeId" : 2980548,
    "displayName" : "TSC2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2249,
      "y" : 464
    },
    "minX" : 2181,
    "maxX" : 2275,
    "minY" : 447,
    "maxY" : 524,
    "prop" : {
      "x" : 2230,
      "y" : 453,
      "width" : 39,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2230,
      "y" : 453
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2269,
          "y" : 453
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2269,
          "y" : 453
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 365,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2236,
          "y" : 478
        },
        "to" : {
          "x" : 2181,
          "y" : 524
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 2067,
    "reactomeId" : 9980228,
    "displayName" : "mTORC2:PIP3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 804,
      "y" : 146
    },
    "minX" : 650,
    "maxX" : 855,
    "minY" : 129,
    "maxY" : 372,
    "prop" : {
      "x" : 763,
      "y" : 135,
      "width" : 82,
      "height" : 23
    },
    "textPosition" : {
      "x" : 772,
      "y" : 123
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 845,
          "y" : 135
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 845,
          "y" : 135
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 360,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 799,
          "y" : 161
        },
        "to" : {
          "x" : 771,
          "y" : 225
        }
      }, {
        "from" : {
          "x" : 771,
          "y" : 225
        },
        "to" : {
          "x" : 658,
          "y" : 214
        }
      }, {
        "from" : {
          "x" : 658,
          "y" : 214
        },
        "to" : {
          "x" : 654,
          "y" : 190
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 654,
          "y" : 186
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 654,
          "y" : 186
        }
      }
    }, {
      "edgeId" : 1975,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 806,
          "y" : 161
        },
        "to" : {
          "x" : 851,
          "y" : 364
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 851,
          "y" : 368
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 851,
          "y" : 368
        }
      }
    } ]
  }, {
    "id" : 788,
    "reactomeId" : 109606,
    "displayName" : "Intrinsic Pathway for Apoptosis",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1757,
      "y" : 1055
    },
    "minX" : 1682,
    "maxX" : 1833,
    "minY" : 1024,
    "maxY" : 1086,
    "prop" : {
      "x" : 1682,
      "y" : 1024,
      "width" : 151,
      "height" : 62
    },
    "textPosition" : {
      "x" : 1684,
      "y" : 1033
    },
    "connectors" : [ ]
  }, {
    "id" : 1557,
    "reactomeId" : 1268261,
    "displayName" : "p-T,Y MAPK dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2035,
      "y" : 1185
    },
    "minX" : 1973,
    "maxX" : 2143,
    "minY" : 1171,
    "maxY" : 1268,
    "prop" : {
      "x" : 1973,
      "y" : 1171,
      "width" : 125,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1975,
      "y" : 1175
    },
    "connectors" : [ {
      "edgeId" : 1556,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2034,
          "y" : 1206
        },
        "to" : {
          "x" : 2034,
          "y" : 1268
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1560,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2087,
          "y" : 1206
        },
        "to" : {
          "x" : 2143,
          "y" : 1215
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2094,
          "y" : 1203
        },
        "b" : {
          "x" : 2087,
          "y" : 1206
        },
        "c" : {
          "x" : 2093,
          "y" : 1211
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2093,
          "y" : 1211
        }
      }
    } ]
  }, {
    "id" : 1558,
    "reactomeId" : 6811515,
    "displayName" : "IER3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2079,
      "y" : 1253
    },
    "minX" : 2034,
    "maxX" : 2143,
    "minY" : 1215,
    "maxY" : 1268,
    "prop" : {
      "x" : 2061,
      "y" : 1242,
      "width" : 37,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2062,
      "y" : 1242
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2098,
          "y" : 1242
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2098,
          "y" : 1242
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1556,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2058,
          "y" : 1259
        },
        "to" : {
          "x" : 2034,
          "y" : 1268
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1560,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2097,
          "y" : 1239
        },
        "to" : {
          "x" : 2143,
          "y" : 1215
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2101,
          "y" : 1232
        },
        "b" : {
          "x" : 2097,
          "y" : 1239
        },
        "c" : {
          "x" : 2105,
          "y" : 1239
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2105,
          "y" : 1239
        }
      }
    } ]
  }, {
    "id" : 534,
    "reactomeId" : 2317310,
    "displayName" : "p-S-AKT:PIP3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 766,
      "y" : 109
    },
    "minX" : 705,
    "maxX" : 1488,
    "minY" : 47,
    "maxY" : 172,
    "prop" : {
      "x" : 721,
      "y" : 97,
      "width" : 91,
      "height" : 24
    },
    "textPosition" : {
      "x" : 724,
      "y" : 100
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 812,
          "y" : 97
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 812,
          "y" : 97
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 544,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 776,
          "y" : 94
        },
        "to" : {
          "x" : 819,
          "y" : 50
        }
      }, {
        "from" : {
          "x" : 819,
          "y" : 50
        },
        "to" : {
          "x" : 1488,
          "y" : 47
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 360,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 754,
          "y" : 124
        },
        "to" : {
          "x" : 705,
          "y" : 172
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 752,
          "y" : 132
        },
        "b" : {
          "x" : 754,
          "y" : 124
        },
        "c" : {
          "x" : 746,
          "y" : 126
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 746,
          "y" : 126
        }
      }
    } ]
  }, {
    "id" : 1559,
    "reactomeId" : 6811477,
    "displayName" : "PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2033,
      "y" : 1378
    },
    "minX" : 1953,
    "maxX" : 2143,
    "minY" : 1263,
    "maxY" : 1399,
    "prop" : {
      "x" : 1953,
      "y" : 1357,
      "width" : 161,
      "height" : 42
    },
    "textPosition" : {
      "x" : 1956,
      "y" : 1364
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2114,
          "y" : 1357
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2114,
          "y" : 1357
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1556,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1560,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2078,
          "y" : 1354
        },
        "to" : {
          "x" : 2143,
          "y" : 1327
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1560,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2047,
          "y" : 1354
        },
        "to" : {
          "x" : 2112,
          "y" : 1267
        }
      }, {
        "from" : {
          "x" : 2112,
          "y" : 1267
        },
        "to" : {
          "x" : 2128,
          "y" : 1267
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2132,
          "y" : 1267
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2132,
          "y" : 1267
        }
      }
    } ]
  }, {
    "id" : 535,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 737,
      "y" : 202
    },
    "minX" : 705,
    "maxX" : 756,
    "minY" : 172,
    "maxY" : 214,
    "prop" : {
      "x" : 719,
      "y" : 190,
      "width" : 36,
      "height" : 24
    },
    "textPosition" : {
      "x" : 720,
      "y" : 191
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 750,
          "y" : 195
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 750,
          "y" : 195
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 360,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 724,
          "y" : 187
        },
        "to" : {
          "x" : 705,
          "y" : 172
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 716,
          "y" : 186
        },
        "b" : {
          "x" : 724,
          "y" : 187
        },
        "c" : {
          "x" : 721,
          "y" : 180
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 721,
          "y" : 180
        }
      }
    } ]
  }, {
    "id" : 1561,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2190,
      "y" : 1354
    },
    "minX" : 2143,
    "maxX" : 2216,
    "minY" : 1327,
    "maxY" : 1367,
    "prop" : {
      "x" : 2165,
      "y" : 1342,
      "width" : 50,
      "height" : 25
    },
    "textPosition" : {
      "x" : 2174,
      "y" : 1344
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2210,
          "y" : 1347
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2210,
          "y" : 1347
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1560,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2168,
          "y" : 1339
        },
        "to" : {
          "x" : 2143,
          "y" : 1327
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 537,
    "reactomeId" : 377179,
    "displayName" : "PDPK1:PIP3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1509,
      "y" : 107
    },
    "minX" : 1156,
    "maxX" : 1626,
    "minY" : 47,
    "maxY" : 356,
    "prop" : {
      "x" : 1469,
      "y" : 96,
      "width" : 80,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1469,
      "y" : 97
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1549,
          "y" : 96
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1549,
          "y" : 96
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1988,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1507,
          "y" : 121
        },
        "to" : {
          "x" : 1472,
          "y" : 354
        }
      }, {
        "from" : {
          "x" : 1472,
          "y" : 354
        },
        "to" : {
          "x" : 1164,
          "y" : 352
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1160,
          "y" : 352
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1160,
          "y" : 352
        }
      }
    }, {
      "edgeId" : 536,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 544,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1505,
          "y" : 93
        },
        "to" : {
          "x" : 1488,
          "y" : 47
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 362,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1517,
          "y" : 121
        },
        "to" : {
          "x" : 1626,
          "y" : 253
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1524,
          "y" : 124
        },
        "b" : {
          "x" : 1517,
          "y" : 121
        },
        "c" : {
          "x" : 1518,
          "y" : 129
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1518,
          "y" : 129
        }
      }
    } ]
  }, {
    "id" : 1562,
    "reactomeId" : 6811475,
    "displayName" : "p-S368-PPP2R5B,p-S337-PPP2R5C",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2186,
      "y" : 1079
    },
    "minX" : 2126,
    "maxX" : 2247,
    "minY" : 1058,
    "maxY" : 1215,
    "prop" : {
      "x" : 2126,
      "y" : 1058,
      "width" : 121,
      "height" : 43
    },
    "textPosition" : {
      "x" : 2128,
      "y" : 1062
    },
    "connectors" : [ {
      "edgeId" : 1560,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2179,
          "y" : 1107
        },
        "to" : {
          "x" : 2143,
          "y" : 1215
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2181,
          "y" : 1115
        },
        "b" : {
          "x" : 2179,
          "y" : 1107
        },
        "c" : {
          "x" : 2173,
          "y" : 1112
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2173,
          "y" : 1112
        }
      }
    } ]
  }, {
    "id" : 1563,
    "reactomeId" : 6811485,
    "displayName" : "PP2A-A:PP2A-C",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2100,
      "y" : 1131
    },
    "minX" : 2049,
    "maxX" : 2158,
    "minY" : 1113,
    "maxY" : 1215,
    "prop" : {
      "x" : 2049,
      "y" : 1119,
      "width" : 103,
      "height" : 24
    },
    "textPosition" : {
      "x" : 2050,
      "y" : 1122
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2152,
          "y" : 1119
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2152,
          "y" : 1119
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1560,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2106,
          "y" : 1146
        },
        "to" : {
          "x" : 2143,
          "y" : 1215
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2113,
          "y" : 1150
        },
        "b" : {
          "x" : 2106,
          "y" : 1146
        },
        "c" : {
          "x" : 2106,
          "y" : 1154
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2106,
          "y" : 1154
        }
      }
    } ]
  }, {
    "id" : 1564,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2201,
      "y" : 1176
    },
    "minX" : 2143,
    "maxX" : 2227,
    "minY" : 1162,
    "maxY" : 1215,
    "prop" : {
      "x" : 2176,
      "y" : 1163,
      "width" : 50,
      "height" : 27
    },
    "textPosition" : {
      "x" : 2184,
      "y" : 1166
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2221,
          "y" : 1168
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2221,
          "y" : 1168
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1560,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2180,
          "y" : 1193
        },
        "to" : {
          "x" : 2143,
          "y" : 1215
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2176,
          "y" : 1200
        },
        "b" : {
          "x" : 2180,
          "y" : 1193
        },
        "c" : {
          "x" : 2172,
          "y" : 1193
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2172,
          "y" : 1193
        }
      }
    } ]
  }, {
    "id" : 545,
    "reactomeId" : 2317313,
    "displayName" : "p-S-AKT:PDPK1:PIP3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1684,
      "y" : 113
    },
    "minX" : 1612,
    "maxX" : 1762,
    "minY" : 96,
    "maxY" : 210,
    "prop" : {
      "x" : 1612,
      "y" : 102,
      "width" : 144,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1619,
      "y" : 104
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1756,
          "y" : 102
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1756,
          "y" : 102
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 544,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 362,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1672,
          "y" : 128
        },
        "to" : {
          "x" : 1625,
          "y" : 172
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 362,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1679,
          "y" : 128
        },
        "to" : {
          "x" : 1648,
          "y" : 196
        }
      }, {
        "from" : {
          "x" : 1648,
          "y" : 196
        },
        "to" : {
          "x" : 1638,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1635,
          "y" : 206
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1635,
          "y" : 206
        }
      }
    } ]
  }, {
    "id" : 1571,
    "reactomeId" : 5673001,
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1943,
      "y" : 1054
    },
    "minX" : 1872,
    "maxX" : 2015,
    "minY" : 1027,
    "maxY" : 1081,
    "prop" : {
      "x" : 1872,
      "y" : 1027,
      "width" : 143,
      "height" : 54
    },
    "textPosition" : {
      "x" : 1884,
      "y" : 1032
    },
    "connectors" : [ ]
  }, {
    "id" : 548,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1582,
      "y" : 166
    },
    "minX" : 1563,
    "maxX" : 1625,
    "minY" : 151,
    "maxY" : 180,
    "prop" : {
      "x" : 1563,
      "y" : 152,
      "width" : 39,
      "height" : 28
    },
    "textPosition" : {
      "x" : 1567,
      "y" : 155
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1597,
          "y" : 157
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1597,
          "y" : 157
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 362,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1605,
          "y" : 168
        },
        "to" : {
          "x" : 1625,
          "y" : 172
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 551,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1580,
      "y" : 285
    },
    "minX" : 1560,
    "maxX" : 1626,
    "minY" : 253,
    "maxY" : 298,
    "prop" : {
      "x" : 1560,
      "y" : 273,
      "width" : 41,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1564,
      "y" : 275
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1596,
          "y" : 278
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1596,
          "y" : 278
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 362,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1597,
          "y" : 270
        },
        "to" : {
          "x" : 1626,
          "y" : 253
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1601,
          "y" : 263
        },
        "b" : {
          "x" : 1597,
          "y" : 270
        },
        "c" : {
          "x" : 1605,
          "y" : 270
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1605,
          "y" : 270
        }
      }
    } ]
  }, {
    "id" : 555,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1595,
      "y" : 519
    },
    "minX" : 1575,
    "maxX" : 1616,
    "minY" : 505,
    "maxY" : 559,
    "prop" : {
      "x" : 1575,
      "y" : 506,
      "width" : 40,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1578,
      "y" : 508
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1610,
          "y" : 511
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1610,
          "y" : 511
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 378,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1591,
          "y" : 535
        },
        "to" : {
          "x" : 1583,
          "y" : 559
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 556,
    "reactomeId" : 202084,
    "displayName" : "p-T-AKT",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1472,
      "y" : 611
    },
    "minX" : 1439,
    "maxX" : 1505,
    "minY" : 563,
    "maxY" : 628,
    "prop" : {
      "x" : 1439,
      "y" : 595,
      "width" : 66,
      "height" : 33
    },
    "textPosition" : {
      "x" : 1445,
      "y" : 601
    },
    "connectors" : [ {
      "edgeId" : 378,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1479,
          "y" : 589
        },
        "to" : {
          "x" : 1495,
          "y" : 563
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1479,
          "y" : 581
        },
        "b" : {
          "x" : 1479,
          "y" : 589
        },
        "c" : {
          "x" : 1486,
          "y" : 585
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1486,
          "y" : 585
        }
      }
    } ]
  }, {
    "id" : 815,
    "reactomeId" : 177929,
    "displayName" : "Signaling by EGFR",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 80,
      "y" : 116
    },
    "minX" : 9,
    "maxX" : 151,
    "minY" : 95,
    "maxY" : 138,
    "prop" : {
      "x" : 9,
      "y" : 95,
      "width" : 142,
      "height" : 43
    },
    "textPosition" : {
      "x" : 16,
      "y" : 102
    },
    "connectors" : [ ]
  }, {
    "id" : 816,
    "reactomeId" : 1227986,
    "displayName" : "Signaling by ERBB2",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 78,
      "y" : 172
    },
    "minX" : 7,
    "maxX" : 150,
    "minY" : 151,
    "maxY" : 194,
    "prop" : {
      "x" : 7,
      "y" : 151,
      "width" : 143,
      "height" : 43
    },
    "textPosition" : {
      "x" : 11,
      "y" : 158
    },
    "connectors" : [ ]
  }, {
    "id" : 817,
    "reactomeId" : 1236394,
    "displayName" : "Signaling by ERBB4",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 77,
      "y" : 228
    },
    "minX" : 7,
    "maxX" : 148,
    "minY" : 204,
    "maxY" : 252,
    "prop" : {
      "x" : 7,
      "y" : 204,
      "width" : 141,
      "height" : 48
    },
    "textPosition" : {
      "x" : 10,
      "y" : 213
    },
    "connectors" : [ ]
  }, {
    "id" : 818,
    "reactomeId" : 190236,
    "displayName" : "Signaling by FGFR",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 73,
      "y" : 287
    },
    "minX" : 3,
    "maxX" : 143,
    "minY" : 265,
    "maxY" : 309,
    "prop" : {
      "x" : 3,
      "y" : 265,
      "width" : 140,
      "height" : 44
    },
    "textPosition" : {
      "x" : 10,
      "y" : 272
    },
    "connectors" : [ ]
  }, {
    "id" : 819,
    "reactomeId" : 186797,
    "displayName" : "Signaling by PDGF",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 72,
      "y" : 340
    },
    "minX" : 2,
    "maxX" : 142,
    "minY" : 319,
    "maxY" : 362,
    "prop" : {
      "x" : 2,
      "y" : 319,
      "width" : 140,
      "height" : 43
    },
    "textPosition" : {
      "x" : 8,
      "y" : 326
    },
    "connectors" : [ ]
  }, {
    "id" : 307,
    "reactomeId" : 202072,
    "displayName" : "p-T,p-S-AKT",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1284,
      "y" : 1030
    },
    "minX" : 1152,
    "maxX" : 1330,
    "minY" : 983,
    "maxY" : 1060,
    "prop" : {
      "x" : 1238,
      "y" : 1017,
      "width" : 92,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1245,
      "y" : 1020
    },
    "connectors" : [ {
      "edgeId" : 363,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 372,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1261,
          "y" : 1011
        },
        "to" : {
          "x" : 1217,
          "y" : 989
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1214,
          "y" : 987
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1214,
          "y" : 987
        }
      }
    }, {
      "edgeId" : 373,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1232,
          "y" : 1018
        },
        "to" : {
          "x" : 1197,
          "y" : 1009
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1193,
          "y" : 1008
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1193,
          "y" : 1008
        }
      }
    }, {
      "edgeId" : 374,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1232,
          "y" : 1028
        },
        "to" : {
          "x" : 1179,
          "y" : 1027
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1175,
          "y" : 1027
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1175,
          "y" : 1027
        }
      }
    }, {
      "edgeId" : 375,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1232,
          "y" : 1039
        },
        "to" : {
          "x" : 1160,
          "y" : 1055
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1156,
          "y" : 1056
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1156,
          "y" : 1056
        }
      }
    } ]
  }, {
    "id" : 820,
    "reactomeId" : 1433557,
    "displayName" : "Signaling by SCF-KIT",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 71,
      "y" : 457
    },
    "minX" : 0,
    "maxX" : 142,
    "minY" : 432,
    "maxY" : 483,
    "prop" : {
      "x" : 0,
      "y" : 432,
      "width" : 142,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1,
      "y" : 443
    },
    "connectors" : [ ]
  }, {
    "id" : 821,
    "reactomeId" : 983705,
    "displayName" : "Signaling by the B Cell Receptor (BCR)",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 71,
      "y" : 526
    },
    "minX" : 1,
    "maxX" : 141,
    "minY" : 498,
    "maxY" : 554,
    "prop" : {
      "x" : 1,
      "y" : 498,
      "width" : 140,
      "height" : 56
    },
    "textPosition" : {
      "x" : 2,
      "y" : 504
    },
    "connectors" : [ ]
  }, {
    "id" : 822,
    "reactomeId" : 166520,
    "displayName" : "Signaling by NTRKs",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 70,
      "y" : 395
    },
    "minX" : 0,
    "maxX" : 141,
    "minY" : 372,
    "maxY" : 418,
    "prop" : {
      "x" : 0,
      "y" : 372,
      "width" : 141,
      "height" : 46
    },
    "textPosition" : {
      "x" : 4,
      "y" : 380
    },
    "connectors" : [ ]
  }, {
    "id" : 823,
    "reactomeId" : 388841,
    "displayName" : "Regulation of T cell activation by CD28 family",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 71,
      "y" : 595
    },
    "minX" : 0,
    "maxX" : 143,
    "minY" : 567,
    "maxY" : 624,
    "prop" : {
      "x" : 0,
      "y" : 567,
      "width" : 143,
      "height" : 57
    },
    "textPosition" : {
      "x" : 2,
      "y" : 567
    },
    "connectors" : [ ]
  }, {
    "id" : 1080,
    "reactomeId" : 199846,
    "displayName" : "p-S351-NR4A1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1175,
      "y" : 1328
    },
    "minX" : 1140,
    "maxX" : 1216,
    "minY" : 1241,
    "maxY" : 1347,
    "prop" : {
      "x" : 1140,
      "y" : 1309,
      "width" : 70,
      "height" : 38
    },
    "innerProp" : {
      "x" : 1140,
      "y" : 1315,
      "width" : 70,
      "height" : 32
    },
    "textPosition" : {
      "x" : 1147,
      "y" : 1310
    },
    "nodeAttachments" : [ {
      "reactomeId" : 199851,
      "label" : "P",
      "description" : "O-phospho-L-serine at 351",
      "shape" : {
        "a" : {
          "x" : 1150,
          "y" : 1303
        },
        "b" : {
          "x" : 1162,
          "y" : 1315
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1156,
          "y" : 1309
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1210,
          "y" : 1309
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1210,
          "y" : 1309
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 375,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1169,
          "y" : 1306
        },
        "to" : {
          "x" : 1148,
          "y" : 1241
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1163,
          "y" : 1301
        },
        "b" : {
          "x" : 1169,
          "y" : 1306
        },
        "c" : {
          "x" : 1171,
          "y" : 1298
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1171,
          "y" : 1298
        }
      }
    } ]
  }, {
    "id" : 312,
    "reactomeId" : 202074,
    "displayName" : "p-T,p-S-AKT",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1625,
      "y" : 610
    },
    "minX" : 1579,
    "maxX" : 2174,
    "minY" : 253,
    "maxY" : 764,
    "prop" : {
      "x" : 1579,
      "y" : 595,
      "width" : 93,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1587,
      "y" : 599
    },
    "connectors" : [ {
      "edgeId" : 1863,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1678,
          "y" : 608
        },
        "to" : {
          "x" : 1896,
          "y" : 603
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1900,
          "y" : 603
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1900,
          "y" : 603
        }
      }
    }, {
      "edgeId" : 362,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1625,
          "y" : 589
        },
        "to" : {
          "x" : 1626,
          "y" : 253
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1621,
          "y" : 582
        },
        "b" : {
          "x" : 1625,
          "y" : 589
        },
        "c" : {
          "x" : 1629,
          "y" : 582
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1629,
          "y" : 582
        }
      }
    }, {
      "edgeId" : 363,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 364,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1678,
          "y" : 620
        },
        "to" : {
          "x" : 2129,
          "y" : 721
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2133,
          "y" : 722
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2133,
          "y" : 722
        }
      }
    }, {
      "edgeId" : 365,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1678,
          "y" : 617
        },
        "to" : {
          "x" : 2166,
          "y" : 700
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2170,
          "y" : 701
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2170,
          "y" : 701
        }
      }
    }, {
      "edgeId" : 366,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1678,
          "y" : 623
        },
        "to" : {
          "x" : 2110,
          "y" : 746
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2113,
          "y" : 747
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2113,
          "y" : 747
        }
      }
    }, {
      "edgeId" : 367,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1678,
          "y" : 615
        },
        "to" : {
          "x" : 1934,
          "y" : 646
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1938,
          "y" : 647
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1938,
          "y" : 647
        }
      }
    }, {
      "edgeId" : 368,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1678,
          "y" : 601
        },
        "to" : {
          "x" : 1854,
          "y" : 569
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1858,
          "y" : 568
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1858,
          "y" : 568
        }
      }
    }, {
      "edgeId" : 369,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1671,
          "y" : 631
        },
        "to" : {
          "x" : 2085,
          "y" : 759
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2089,
          "y" : 760
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2089,
          "y" : 760
        }
      }
    }, {
      "edgeId" : 370,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1678,
          "y" : 605
        },
        "to" : {
          "x" : 1874,
          "y" : 587
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1878,
          "y" : 586
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1878,
          "y" : 586
        }
      }
    }, {
      "edgeId" : 371,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1678,
          "y" : 612
        },
        "to" : {
          "x" : 1916,
          "y" : 623
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1920,
          "y" : 623
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1920,
          "y" : 623
        }
      }
    }, {
      "edgeId" : 378,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1612,
          "y" : 589
        },
        "to" : {
          "x" : 1583,
          "y" : 559
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1081,
    "reactomeId" : 199844,
    "displayName" : "p-S15,S356-RPS6KB2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1268,
      "y" : 1184
    },
    "minX" : 1185,
    "maxX" : 1320,
    "minY" : 1156,
    "maxY" : 1205,
    "prop" : {
      "x" : 1223,
      "y" : 1163,
      "width" : 91,
      "height" : 42
    },
    "innerProp" : {
      "x" : 1223,
      "y" : 1169,
      "width" : 91,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1226,
      "y" : 1166
    },
    "nodeAttachments" : [ {
      "reactomeId" : 199837,
      "label" : "P",
      "description" : "O-phospho-L-serine at 15",
      "shape" : {
        "a" : {
          "x" : 1234,
          "y" : 1157
        },
        "b" : {
          "x" : 1246,
          "y" : 1169
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1240,
          "y" : 1163
        }
      }
    }, {
      "reactomeId" : 199876,
      "label" : "P",
      "description" : "O-phospho-L-serine at 356",
      "shape" : {
        "a" : {
          "x" : 1250,
          "y" : 1157
        },
        "b" : {
          "x" : 1262,
          "y" : 1169
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1256,
          "y" : 1163
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1314,
          "y" : 1163
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1314,
          "y" : 1163
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 373,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1220,
          "y" : 1168
        },
        "to" : {
          "x" : 1185,
          "y" : 1156
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1212,
          "y" : 1170
        },
        "b" : {
          "x" : 1220,
          "y" : 1168
        },
        "c" : {
          "x" : 1215,
          "y" : 1162
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1215,
          "y" : 1162
        }
      }
    } ]
  }, {
    "id" : 313,
    "reactomeId" : 179838,
    "displayName" : "PI(3,4,5)P3",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 294,
      "y" : 256
    },
    "minX" : 258,
    "maxX" : 473,
    "minY" : 178,
    "maxY" : 371,
    "prop" : {
      "x" : 258,
      "y" : 240,
      "width" : 73,
      "height" : 32
    },
    "textPosition" : {
      "x" : 264,
      "y" : 239
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 326,
          "y" : 245
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 326,
          "y" : 245
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 582,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 334,
          "y" : 241
        },
        "to" : {
          "x" : 460,
          "y" : 192
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 536,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 302,
          "y" : 237
        },
        "to" : {
          "x" : 333,
          "y" : 178
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 497,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 303,
          "y" : 275
        },
        "to" : {
          "x" : 361,
          "y" : 371
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 310,
          "y" : 279
        },
        "b" : {
          "x" : 303,
          "y" : 275
        },
        "c" : {
          "x" : 303,
          "y" : 283
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 303,
          "y" : 283
        }
      }
    }, {
      "edgeId" : 377,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 323,
          "y" : 275
        },
        "to" : {
          "x" : 473,
          "y" : 353
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1082,
    "reactomeId" : 200163,
    "displayName" : "p-S183,S221,T246-AKT1S1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1710,
      "y" : 825
    },
    "minX" : 1655,
    "maxX" : 1890,
    "minY" : 788,
    "maxY" : 841,
    "prop" : {
      "x" : 1655,
      "y" : 809,
      "width" : 110,
      "height" : 32
    },
    "innerProp" : {
      "x" : 1655,
      "y" : 815,
      "width" : 104,
      "height" : 26
    },
    "textPosition" : {
      "x" : 1664,
      "y" : 808
    },
    "nodeAttachments" : [ {
      "reactomeId" : 377446,
      "label" : "P",
      "description" : "O-phospho-L-serine at 183",
      "shape" : {
        "a" : {
          "x" : 1660,
          "y" : 803
        },
        "b" : {
          "x" : 1672,
          "y" : 815
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1666,
          "y" : 809
        }
      }
    }, {
      "reactomeId" : 200159,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 246",
      "shape" : {
        "a" : {
          "x" : 1671,
          "y" : 803
        },
        "b" : {
          "x" : 1683,
          "y" : 815
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1677,
          "y" : 809
        }
      }
    }, {
      "reactomeId" : 200144,
      "label" : "P",
      "description" : "O-phospho-L-serine at 221",
      "shape" : {
        "a" : {
          "x" : 1759,
          "y" : 807
        },
        "b" : {
          "x" : 1771,
          "y" : 819
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1765,
          "y" : 813
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1765,
          "y" : 809
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1765,
          "y" : 809
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 370,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1768,
          "y" : 813
        },
        "to" : {
          "x" : 1890,
          "y" : 788
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1774,
          "y" : 808
        },
        "b" : {
          "x" : 1768,
          "y" : 813
        },
        "c" : {
          "x" : 1776,
          "y" : 816
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1776,
          "y" : 816
        }
      }
    } ]
  }, {
    "id" : 1083,
    "reactomeId" : 198335,
    "displayName" : "p-S99-BAD",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1757,
      "y" : 940
    },
    "minX" : 1714,
    "maxX" : 1927,
    "minY" : 839,
    "maxY" : 952,
    "prop" : {
      "x" : 1714,
      "y" : 929,
      "width" : 86,
      "height" : 23
    },
    "innerProp" : {
      "x" : 1714,
      "y" : 935,
      "width" : 86,
      "height" : 17
    },
    "textPosition" : {
      "x" : 1720,
      "y" : 930
    },
    "nodeAttachments" : [ {
      "reactomeId" : 198322,
      "label" : "P",
      "description" : "O-phospho-L-serine at 99",
      "shape" : {
        "a" : {
          "x" : 1724,
          "y" : 923
        },
        "b" : {
          "x" : 1736,
          "y" : 935
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1730,
          "y" : 929
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1800,
          "y" : 929
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1800,
          "y" : 929
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 371,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1776,
          "y" : 926
        },
        "to" : {
          "x" : 1927,
          "y" : 839
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1780,
          "y" : 919
        },
        "b" : {
          "x" : 1776,
          "y" : 926
        },
        "c" : {
          "x" : 1784,
          "y" : 926
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1784,
          "y" : 926
        }
      }
    } ]
  }, {
    "id" : 1084,
    "reactomeId" : 199484,
    "displayName" : "p-S939,T1462-TSC2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2315,
      "y" : 824
    },
    "minX" : 2183,
    "maxX" : 2393,
    "minY" : 789,
    "maxY" : 839,
    "prop" : {
      "x" : 2243,
      "y" : 810,
      "width" : 144,
      "height" : 29
    },
    "innerProp" : {
      "x" : 2243,
      "y" : 816,
      "width" : 144,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2250,
      "y" : 814
    },
    "nodeAttachments" : [ {
      "reactomeId" : 199480,
      "label" : "P",
      "description" : "O-phospho-L-serine at 939",
      "shape" : {
        "a" : {
          "x" : 2253,
          "y" : 804
        },
        "b" : {
          "x" : 2265,
          "y" : 816
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 2259,
          "y" : 810
        }
      }
    }, {
      "reactomeId" : 199482,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 1462",
      "shape" : {
        "a" : {
          "x" : 2269,
          "y" : 804
        },
        "b" : {
          "x" : 2281,
          "y" : 816
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 2275,
          "y" : 810
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2387,
          "y" : 810
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2387,
          "y" : 810
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 365,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2260,
          "y" : 807
        },
        "to" : {
          "x" : 2183,
          "y" : 789
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2252,
          "y" : 809
        },
        "b" : {
          "x" : 2260,
          "y" : 807
        },
        "c" : {
          "x" : 2254,
          "y" : 802
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2254,
          "y" : 802
        }
      }
    } ]
  }, {
    "id" : 574,
    "reactomeId" : 2317329,
    "displayName" : "AKT:PIP3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 457,
      "y" : 110
    },
    "minX" : 426,
    "maxX" : 627,
    "minY" : 66,
    "maxY" : 173,
    "prop" : {
      "x" : 426,
      "y" : 99,
      "width" : 63,
      "height" : 23
    },
    "textPosition" : {
      "x" : 427,
      "y" : 101
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 489,
          "y" : 99
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 489,
          "y" : 99
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 582,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 360,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 492,
          "y" : 121
        },
        "to" : {
          "x" : 627,
          "y" : 173
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 376,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 492,
          "y" : 99
        },
        "to" : {
          "x" : 586,
          "y" : 66
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 320,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2009,
      "y" : 534
    },
    "minX" : 1871,
    "maxX" : 2181,
    "minY" : 474,
    "maxY" : 646,
    "prop" : {
      "x" : 1990,
      "y" : 520,
      "width" : 39,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1994,
      "y" : 524
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2024,
          "y" : 525
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2024,
          "y" : 525
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1863,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1987,
          "y" : 533
        },
        "to" : {
          "x" : 1911,
          "y" : 530
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 364,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2032,
          "y" : 539
        },
        "to" : {
          "x" : 2144,
          "y" : 575
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 365,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2032,
          "y" : 532
        },
        "to" : {
          "x" : 2181,
          "y" : 524
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2100,
            "y" : 522
          },
          "b" : {
            "x" : 2112,
            "y" : 534
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2106,
            "y" : 528
          }
        }
      }
    }, {
      "edgeId" : 366,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2032,
          "y" : 548
        },
        "to" : {
          "x" : 2125,
          "y" : 618
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 367,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1987,
          "y" : 547
        },
        "to" : {
          "x" : 1950,
          "y" : 576
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 368,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1987,
          "y" : 525
        },
        "to" : {
          "x" : 1871,
          "y" : 474
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 369,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2020,
          "y" : 552
        },
        "to" : {
          "x" : 2100,
          "y" : 646
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2054,
            "y" : 593
          },
          "b" : {
            "x" : 2066,
            "y" : 605
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2060,
            "y" : 599
          }
        }
      }
    }, {
      "edgeId" : 370,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1987,
          "y" : 528
        },
        "to" : {
          "x" : 1889,
          "y" : 501
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1932,
            "y" : 508
          },
          "b" : {
            "x" : 1944,
            "y" : 520
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1938,
            "y" : 514
          }
        }
      }
    }, {
      "edgeId" : 371,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1987,
          "y" : 537
        },
        "to" : {
          "x" : 1933,
          "y" : 549
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 576,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 611,
      "y" : 204
    },
    "minX" : 593,
    "maxX" : 630,
    "minY" : 173,
    "maxY" : 216,
    "prop" : {
      "x" : 593,
      "y" : 193,
      "width" : 36,
      "height" : 23
    },
    "textPosition" : {
      "x" : 595,
      "y" : 194
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 624,
          "y" : 198
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 624,
          "y" : 198
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 360,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 616,
          "y" : 190
        },
        "to" : {
          "x" : 627,
          "y" : 173
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 321,
    "reactomeId" : 198605,
    "displayName" : "p-T-CDKN1A/B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1688,
      "y" : 773
    },
    "minX" : 1637,
    "maxX" : 1869,
    "minY" : 750,
    "maxY" : 785,
    "prop" : {
      "x" : 1637,
      "y" : 761,
      "width" : 103,
      "height" : 24
    },
    "textPosition" : {
      "x" : 1642,
      "y" : 762
    },
    "connectors" : [ {
      "edgeId" : 368,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1746,
          "y" : 766
        },
        "to" : {
          "x" : 1869,
          "y" : 750
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1752,
          "y" : 761
        },
        "b" : {
          "x" : 1746,
          "y" : 766
        },
        "c" : {
          "x" : 1753,
          "y" : 769
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1753,
          "y" : 769
        }
      }
    } ]
  }, {
    "id" : 323,
    "reactomeId" : 198638,
    "displayName" : "p-S166,S188-MDM2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2160,
      "y" : 978
    },
    "minX" : 2094,
    "maxX" : 2233,
    "minY" : 869,
    "maxY" : 992,
    "prop" : {
      "x" : 2094,
      "y" : 965,
      "width" : 133,
      "height" : 27
    },
    "innerProp" : {
      "x" : 2094,
      "y" : 971,
      "width" : 133,
      "height" : 21
    },
    "textPosition" : {
      "x" : 2096,
      "y" : 968
    },
    "nodeAttachments" : [ {
      "reactomeId" : 2399939,
      "label" : "P",
      "description" : "O-phospho-L-serine at 166",
      "shape" : {
        "a" : {
          "x" : 2104,
          "y" : 959
        },
        "b" : {
          "x" : 2116,
          "y" : 971
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 2110,
          "y" : 965
        }
      }
    }, {
      "reactomeId" : 2399935,
      "label" : "P",
      "description" : "O-phospho-L-serine at 188",
      "shape" : {
        "a" : {
          "x" : 2120,
          "y" : 959
        },
        "b" : {
          "x" : 2132,
          "y" : 971
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 2126,
          "y" : 965
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2227,
          "y" : 965
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2227,
          "y" : 965
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 369,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2152,
          "y" : 962
        },
        "to" : {
          "x" : 2100,
          "y" : 869
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2145,
          "y" : 958
        },
        "b" : {
          "x" : 2152,
          "y" : 962
        },
        "c" : {
          "x" : 2152,
          "y" : 954
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2152,
          "y" : 954
        }
      }
    } ]
  }, {
    "id" : 324,
    "reactomeId" : 198358,
    "displayName" : "GSK3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1772,
      "y" : 537
    },
    "minX" : 1752,
    "maxX" : 1950,
    "minY" : 526,
    "maxY" : 576,
    "prop" : {
      "x" : 1752,
      "y" : 526,
      "width" : 41,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1752,
      "y" : 526
    },
    "connectors" : [ {
      "edgeId" : 367,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1799,
          "y" : 541
        },
        "to" : {
          "x" : 1950,
          "y" : 576
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1861,
    "reactomeId" : 6807070,
    "displayName" : "PTEN Regulation",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 1321,
      "y" : 746
    },
    "minX" : 1255,
    "maxX" : 1388,
    "minY" : 717,
    "maxY" : 776,
    "prop" : {
      "x" : 1255,
      "y" : 717,
      "width" : 133,
      "height" : 59
    },
    "textPosition" : {
      "x" : 1262,
      "y" : 732
    },
    "connectors" : [ ]
  }, {
    "id" : 326,
    "reactomeId" : 50662,
    "displayName" : "BAD",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1778,
      "y" : 498
    },
    "minX" : 1751,
    "maxX" : 1933,
    "minY" : 482,
    "maxY" : 549,
    "prop" : {
      "x" : 1751,
      "y" : 488,
      "width" : 54,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1761,
      "y" : 488
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1805,
          "y" : 488
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1805,
          "y" : 488
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 371,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1808,
          "y" : 506
        },
        "to" : {
          "x" : 1933,
          "y" : 549
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 841,
    "reactomeId" : 453279,
    "displayName" : "Mitotic G1 phase and G1/S transition",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1806,
      "y" : 317
    },
    "minX" : 1713,
    "maxX" : 1899,
    "minY" : 291,
    "maxY" : 343,
    "prop" : {
      "x" : 1713,
      "y" : 291,
      "width" : 186,
      "height" : 52
    },
    "textPosition" : {
      "x" : 1713,
      "y" : 295
    },
    "connectors" : [ ]
  }, {
    "id" : 1865,
    "reactomeId" : 976042,
    "displayName" : "MKRN1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1791,
      "y" : 461
    },
    "minX" : 1765,
    "maxX" : 1911,
    "minY" : 444,
    "maxY" : 530,
    "prop" : {
      "x" : 1765,
      "y" : 450,
      "width" : 52,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1766,
      "y" : 450
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1817,
          "y" : 450
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1817,
          "y" : 450
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1863,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1810,
          "y" : 475
        },
        "to" : {
          "x" : 1911,
          "y" : 530
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 330,
    "reactomeId" : 198644,
    "displayName" : "MDM2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2259,
      "y" : 604
    },
    "minX" : 2100,
    "maxX" : 2288,
    "minY" : 588,
    "maxY" : 646,
    "prop" : {
      "x" : 2237,
      "y" : 594,
      "width" : 45,
      "height" : 21
    },
    "textPosition" : {
      "x" : 2237,
      "y" : 594
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2282,
          "y" : 594
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2282,
          "y" : 594
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 369,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2234,
          "y" : 609
        },
        "to" : {
          "x" : 2100,
          "y" : 646
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1867,
    "reactomeId" : 8948758,
    "displayName" : "p-S109-MKRN1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1726,
      "y" : 889
    },
    "minX" : 1674,
    "maxX" : 1910,
    "minY" : 820,
    "maxY" : 903,
    "prop" : {
      "x" : 1674,
      "y" : 876,
      "width" : 104,
      "height" : 27
    },
    "innerProp" : {
      "x" : 1674,
      "y" : 876,
      "width" : 98,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1677,
      "y" : 879
    },
    "nodeAttachments" : [ {
      "reactomeId" : 8948759,
      "label" : "P",
      "description" : "O-phospho-L-serine at 109",
      "shape" : {
        "a" : {
          "x" : 1772,
          "y" : 880
        },
        "b" : {
          "x" : 1784,
          "y" : 892
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1778,
          "y" : 886
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1778,
          "y" : 876
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1778,
          "y" : 876
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1863,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1762,
          "y" : 873
        },
        "to" : {
          "x" : 1910,
          "y" : 820
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1767,
          "y" : 867
        },
        "b" : {
          "x" : 1762,
          "y" : 873
        },
        "c" : {
          "x" : 1770,
          "y" : 874
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1770,
          "y" : 874
        }
      }
    } ]
  }, {
    "id" : 332,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2014,
      "y" : 800
    },
    "minX" : 1869,
    "maxX" : 2183,
    "minY" : 750,
    "maxY" : 869,
    "prop" : {
      "x" : 1994,
      "y" : 786,
      "width" : 40,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1997,
      "y" : 790
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2029,
          "y" : 791
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2029,
          "y" : 791
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1863,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1991,
          "y" : 803
        },
        "to" : {
          "x" : 1910,
          "y" : 820
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1985,
          "y" : 808
        },
        "b" : {
          "x" : 1991,
          "y" : 803
        },
        "c" : {
          "x" : 1983,
          "y" : 801
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1983,
          "y" : 801
        }
      }
    }, {
      "edgeId" : 364,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2037,
          "y" : 801
        },
        "to" : {
          "x" : 2145,
          "y" : 813
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2044,
          "y" : 798
        },
        "b" : {
          "x" : 2037,
          "y" : 801
        },
        "c" : {
          "x" : 2043,
          "y" : 806
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2043,
          "y" : 806
        }
      }
    }, {
      "edgeId" : 365,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2037,
          "y" : 798
        },
        "to" : {
          "x" : 2183,
          "y" : 789
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2104,
            "y" : 787
          },
          "b" : {
            "x" : 2116,
            "y" : 799
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2110,
            "y" : 793
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2044,
          "y" : 794
        },
        "b" : {
          "x" : 2037,
          "y" : 798
        },
        "c" : {
          "x" : 2044,
          "y" : 802
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2044,
          "y" : 802
        }
      }
    }, {
      "edgeId" : 366,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2037,
          "y" : 807
        },
        "to" : {
          "x" : 2125,
          "y" : 839
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2045,
          "y" : 806
        },
        "b" : {
          "x" : 2037,
          "y" : 807
        },
        "c" : {
          "x" : 2042,
          "y" : 813
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2042,
          "y" : 813
        }
      }
    }, {
      "edgeId" : 367,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1995,
          "y" : 818
        },
        "to" : {
          "x" : 1948,
          "y" : 852
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1992,
          "y" : 825
        },
        "b" : {
          "x" : 1995,
          "y" : 818
        },
        "c" : {
          "x" : 1987,
          "y" : 819
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1987,
          "y" : 819
        }
      }
    }, {
      "edgeId" : 368,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1991,
          "y" : 793
        },
        "to" : {
          "x" : 1869,
          "y" : 750
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1983,
          "y" : 794
        },
        "b" : {
          "x" : 1991,
          "y" : 793
        },
        "c" : {
          "x" : 1986,
          "y" : 787
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1986,
          "y" : 787
        }
      }
    }, {
      "edgeId" : 369,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2032,
          "y" : 818
        },
        "to" : {
          "x" : 2100,
          "y" : 869
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 2060,
            "y" : 837
          },
          "b" : {
            "x" : 2072,
            "y" : 849
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2066,
            "y" : 843
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 2040,
          "y" : 819
        },
        "b" : {
          "x" : 2032,
          "y" : 818
        },
        "c" : {
          "x" : 2035,
          "y" : 825
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2035,
          "y" : 825
        }
      }
    }, {
      "edgeId" : 370,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1991,
          "y" : 798
        },
        "to" : {
          "x" : 1890,
          "y" : 788
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1934,
            "y" : 787
          },
          "b" : {
            "x" : 1946,
            "y" : 799
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1940,
            "y" : 793
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1984,
          "y" : 801
        },
        "b" : {
          "x" : 1991,
          "y" : 798
        },
        "c" : {
          "x" : 1984,
          "y" : 793
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1984,
          "y" : 793
        }
      }
    }, {
      "edgeId" : 371,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1991,
          "y" : 808
        },
        "to" : {
          "x" : 1927,
          "y" : 839
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1987,
          "y" : 815
        },
        "b" : {
          "x" : 1991,
          "y" : 808
        },
        "c" : {
          "x" : 1983,
          "y" : 807
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1983,
          "y" : 807
        }
      }
    } ]
  }, {
    "id" : 1869,
    "reactomeId" : 8981951,
    "displayName" : "IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 479,
      "y" : 595
    },
    "minX" : 369,
    "maxX" : 550,
    "minY" : 402,
    "maxY" : 620,
    "prop" : {
      "x" : 415,
      "y" : 570,
      "width" : 129,
      "height" : 50
    },
    "textPosition" : {
      "x" : 417,
      "y" : 571
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 544,
          "y" : 570
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 544,
          "y" : 570
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 497,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 472,
          "y" : 567
        },
        "to" : {
          "x" : 428,
          "y" : 404
        }
      }, {
        "from" : {
          "x" : 428,
          "y" : 404
        },
        "to" : {
          "x" : 369,
          "y" : 406
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 376,
          "y" : 402
        },
        "b" : {
          "x" : 369,
          "y" : 406
        },
        "c" : {
          "x" : 376,
          "y" : 410
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 376,
          "y" : 410
        }
      }
    } ]
  }, {
    "id" : 334,
    "reactomeId" : 200155,
    "displayName" : "AKT1S1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1890,
      "y" : 394
    },
    "minX" : 1860,
    "maxX" : 1927,
    "minY" : 374,
    "maxY" : 501,
    "prop" : {
      "x" : 1860,
      "y" : 380,
      "width" : 61,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1863,
      "y" : 384
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1921,
          "y" : 380
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1921,
          "y" : 380
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 370,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1889,
          "y" : 412
        },
        "to" : {
          "x" : 1889,
          "y" : 501
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1870,
    "reactomeId" : 9009391,
    "displayName" : "Extra-nuclear estrogen signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 73,
      "y" : 789
    },
    "minX" : 5,
    "maxX" : 142,
    "minY" : 761,
    "maxY" : 817,
    "prop" : {
      "x" : 5,
      "y" : 761,
      "width" : 137,
      "height" : 56
    },
    "textPosition" : {
      "x" : 7,
      "y" : 767
    },
    "connectors" : [ ]
  }, {
    "id" : 335,
    "reactomeId" : 198373,
    "displayName" : "p-S9/21-GSK3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1861,
      "y" : 970
    },
    "minX" : 1810,
    "maxX" : 1948,
    "minY" : 852,
    "maxY" : 981,
    "prop" : {
      "x" : 1810,
      "y" : 959,
      "width" : 102,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1815,
      "y" : 959
    },
    "connectors" : [ {
      "edgeId" : 367,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1869,
          "y" : 953
        },
        "to" : {
          "x" : 1948,
          "y" : 852
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1870,
          "y" : 945
        },
        "b" : {
          "x" : 1869,
          "y" : 953
        },
        "c" : {
          "x" : 1876,
          "y" : 950
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1876,
          "y" : 950
        }
      }
    } ]
  }, {
    "id" : 336,
    "reactomeId" : 168104,
    "displayName" : "CHUK",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2253,
      "y" : 513
    },
    "minX" : 2144,
    "maxX" : 2280,
    "minY" : 497,
    "maxY" : 575,
    "prop" : {
      "x" : 2232,
      "y" : 503,
      "width" : 42,
      "height" : 21
    },
    "textPosition" : {
      "x" : 2232,
      "y" : 503
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2274,
          "y" : 503
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2274,
          "y" : 503
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 364,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2234,
          "y" : 527
        },
        "to" : {
          "x" : 2144,
          "y" : 575
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 337,
    "reactomeId" : 199831,
    "displayName" : "NR4A1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1270,
      "y" : 965
    },
    "minX" : 1141,
    "maxX" : 1301,
    "minY" : 945,
    "maxY" : 979,
    "prop" : {
      "x" : 1246,
      "y" : 951,
      "width" : 49,
      "height" : 28
    },
    "textPosition" : {
      "x" : 1246,
      "y" : 954
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1295,
          "y" : 951
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1295,
          "y" : 951
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 375,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1243,
          "y" : 965
        },
        "to" : {
          "x" : 1141,
          "y" : 969
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 339,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1037,
      "y" : 1241
    },
    "minX" : 1012,
    "maxX" : 1210,
    "minY" : 1092,
    "maxY" : 1255,
    "prop" : {
      "x" : 1012,
      "y" : 1228,
      "width" : 51,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1021,
      "y" : 1231
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1058,
          "y" : 1233
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1058,
          "y" : 1233
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 372,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1052,
          "y" : 1225
        },
        "to" : {
          "x" : 1210,
          "y" : 1092
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1055,
          "y" : 1217
        },
        "b" : {
          "x" : 1052,
          "y" : 1225
        },
        "c" : {
          "x" : 1060,
          "y" : 1224
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1060,
          "y" : 1224
        }
      }
    }, {
      "edgeId" : 373,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1060,
          "y" : 1225
        },
        "to" : {
          "x" : 1185,
          "y" : 1156
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1116,
            "y" : 1184
          },
          "b" : {
            "x" : 1128,
            "y" : 1196
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1122,
            "y" : 1190
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1064,
          "y" : 1218
        },
        "b" : {
          "x" : 1060,
          "y" : 1225
        },
        "c" : {
          "x" : 1068,
          "y" : 1225
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1068,
          "y" : 1225
        }
      }
    }, {
      "edgeId" : 374,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1066,
          "y" : 1230
        },
        "to" : {
          "x" : 1166,
          "y" : 1188
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1110,
            "y" : 1203
          },
          "b" : {
            "x" : 1122,
            "y" : 1215
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1116,
            "y" : 1209
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1071,
          "y" : 1224
        },
        "b" : {
          "x" : 1066,
          "y" : 1230
        },
        "c" : {
          "x" : 1074,
          "y" : 1231
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1074,
          "y" : 1231
        }
      }
    }, {
      "edgeId" : 375,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1066,
          "y" : 1241
        },
        "to" : {
          "x" : 1148,
          "y" : 1241
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1073,
          "y" : 1237
        },
        "b" : {
          "x" : 1066,
          "y" : 1241
        },
        "c" : {
          "x" : 1073,
          "y" : 1245
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1073,
          "y" : 1245
        }
      }
    } ]
  }, {
    "id" : 340,
    "reactomeId" : 199877,
    "displayName" : "RPS6KB2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1259,
      "y" : 864
    },
    "minX" : 1181,
    "maxX" : 1304,
    "minY" : 844,
    "maxY" : 932,
    "prop" : {
      "x" : 1220,
      "y" : 850,
      "width" : 78,
      "height" : 28
    },
    "textPosition" : {
      "x" : 1227,
      "y" : 853
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1298,
          "y" : 850
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1298,
          "y" : 850
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 373,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1242,
          "y" : 881
        },
        "to" : {
          "x" : 1181,
          "y" : 932
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 342,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1032,
      "y" : 887
    },
    "minX" : 1006,
    "maxX" : 1201,
    "minY" : 873,
    "maxY" : 969,
    "prop" : {
      "x" : 1006,
      "y" : 874,
      "width" : 53,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1017,
      "y" : 877
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1054,
          "y" : 879
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1054,
          "y" : 879
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 372,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1062,
          "y" : 885
        },
        "to" : {
          "x" : 1201,
          "y" : 878
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 373,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1062,
          "y" : 895
        },
        "to" : {
          "x" : 1181,
          "y" : 932
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1115,
            "y" : 907
          },
          "b" : {
            "x" : 1127,
            "y" : 919
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1121,
            "y" : 913
          }
        }
      }
    }, {
      "edgeId" : 374,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1062,
          "y" : 899
        },
        "to" : {
          "x" : 1161,
          "y" : 949
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1105,
            "y" : 918
          },
          "b" : {
            "x" : 1117,
            "y" : 930
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1111,
            "y" : 924
          }
        }
      }
    }, {
      "edgeId" : 375,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1049,
          "y" : 904
        },
        "to" : {
          "x" : 1141,
          "y" : 969
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1879,
    "reactomeId" : 202131,
    "displayName" : "Metabolism of nitric oxide: NOS3 activation and regulation",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1520,
      "y" : 1178
    },
    "minX" : 1445,
    "maxX" : 1595,
    "minY" : 1142,
    "maxY" : 1215,
    "prop" : {
      "x" : 1445,
      "y" : 1142,
      "width" : 150,
      "height" : 73
    },
    "textPosition" : {
      "x" : 1449,
      "y" : 1143
    },
    "connectors" : [ ]
  }, {
    "id" : 343,
    "reactomeId" : 52777,
    "displayName" : "CREB1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1226,
      "y" : 825
    },
    "minX" : 1201,
    "maxX" : 1257,
    "minY" : 806,
    "maxY" : 878,
    "prop" : {
      "x" : 1202,
      "y" : 812,
      "width" : 49,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1202,
      "y" : 815
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1251,
          "y" : 812
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1251,
          "y" : 812
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 372,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1219,
          "y" : 842
        },
        "to" : {
          "x" : 1201,
          "y" : 878
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1882,
    "reactomeId" : 9614997,
    "displayName" : "p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1294,
      "y" : 1268
    },
    "minX" : 1166,
    "maxX" : 1362,
    "minY" : 1188,
    "maxY" : 1312,
    "prop" : {
      "x" : 1226,
      "y" : 1225,
      "width" : 136,
      "height" : 87
    },
    "textPosition" : {
      "x" : 1227,
      "y" : 1230
    },
    "connectors" : [ {
      "edgeId" : 374,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1220,
          "y" : 1225
        },
        "to" : {
          "x" : 1166,
          "y" : 1188
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1212,
          "y" : 1224
        },
        "b" : {
          "x" : 1220,
          "y" : 1225
        },
        "c" : {
          "x" : 1217,
          "y" : 1218
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1217,
          "y" : 1218
        }
      }
    } ]
  }, {
    "id" : 346,
    "reactomeId" : 199272,
    "displayName" : "FOXO1,FOXO3,FOXO4,(FOXO6)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1288,
      "y" : 919
    },
    "minX" : 1161,
    "maxX" : 1339,
    "minY" : 896,
    "maxY" : 949,
    "prop" : {
      "x" : 1238,
      "y" : 896,
      "width" : 101,
      "height" : 47
    },
    "textPosition" : {
      "x" : 1240,
      "y" : 895
    },
    "connectors" : [ {
      "edgeId" : 374,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1232,
          "y" : 930
        },
        "to" : {
          "x" : 1161,
          "y" : 949
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 347,
    "reactomeId" : 199453,
    "displayName" : "AKT:PIP3:THEM4/TRIB3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 661,
      "y" : 109
    },
    "minX" : 616,
    "maxX" : 713,
    "minY" : 85,
    "maxY" : 166,
    "prop" : {
      "x" : 616,
      "y" : 91,
      "width" : 91,
      "height" : 36
    },
    "textPosition" : {
      "x" : 617,
      "y" : 92
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 707,
          "y" : 91
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 707,
          "y" : 91
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 360,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 658,
          "y" : 130
        },
        "to" : {
          "x" : 653,
          "y" : 165
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 649,
          "y" : 164
        },
        "b" : {
          "x" : 657,
          "y" : 166
        },
        "c" : {
          "x" : 653,
          "y" : 165
        },
        "type" : "STOP",
        "centre" : {
          "x" : 653,
          "y" : 165
        }
      }
    }, {
      "edgeId" : 376,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 352,
    "reactomeId" : 199450,
    "displayName" : "PHLPP (Mn2+ cofactor)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1539,
      "y" : 492
    },
    "minX" : 1506,
    "maxX" : 1578,
    "minY" : 463,
    "maxY" : 553,
    "prop" : {
      "x" : 1506,
      "y" : 469,
      "width" : 66,
      "height" : 46
    },
    "textPosition" : {
      "x" : 1506,
      "y" : 466
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1572,
          "y" : 469
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1572,
          "y" : 469
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 378,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1539,
          "y" : 518
        },
        "to" : {
          "x" : 1539,
          "y" : 545
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1539,
          "y" : 549
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1539,
          "y" : 549
        }
      }
    } ]
  }, {
    "id" : 353,
    "reactomeId" : 179856,
    "displayName" : "PI(4,5)P2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 292,
      "y" : 601
    },
    "minX" : 210,
    "maxX" : 488,
    "minY" : 230,
    "maxY" : 1165,
    "prop" : {
      "x" : 261,
      "y" : 585,
      "width" : 63,
      "height" : 32
    },
    "textPosition" : {
      "x" : 268,
      "y" : 584
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 319,
          "y" : 590
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 319,
          "y" : 590
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 419,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 277,
          "y" : 582
        },
        "to" : {
          "x" : 210,
          "y" : 510
        }
      }, {
        "from" : {
          "x" : 210,
          "y" : 510
        },
        "to" : {
          "x" : 237,
          "y" : 230
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 497,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 298,
          "y" : 582
        },
        "to" : {
          "x" : 360,
          "y" : 440
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1526,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 296,
          "y" : 620
        },
        "to" : {
          "x" : 439,
          "y" : 1165
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 302,
          "y" : 626
        },
        "b" : {
          "x" : 296,
          "y" : 620
        },
        "c" : {
          "x" : 294,
          "y" : 628
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 294,
          "y" : 628
        }
      }
    }, {
      "edgeId" : 377,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 308,
          "y" : 582
        },
        "to" : {
          "x" : 473,
          "y" : 421
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 310,
          "y" : 574
        },
        "b" : {
          "x" : 308,
          "y" : 582
        },
        "c" : {
          "x" : 316,
          "y" : 580
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 316,
          "y" : 580
        }
      }
    }, {
      "edgeId" : 1531,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 298,
          "y" : 620
        },
        "to" : {
          "x" : 488,
          "y" : 1108
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 304,
          "y" : 625
        },
        "b" : {
          "x" : 298,
          "y" : 620
        },
        "c" : {
          "x" : 297,
          "y" : 628
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 297,
          "y" : 628
        }
      }
    } ]
  }, {
    "id" : 355,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 524,
      "y" : 324
    },
    "minX" : 473,
    "maxX" : 545,
    "minY" : 308,
    "maxY" : 353,
    "prop" : {
      "x" : 505,
      "y" : 309,
      "width" : 39,
      "height" : 31
    },
    "textPosition" : {
      "x" : 507,
      "y" : 314
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 539,
          "y" : 314
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 539,
          "y" : 314
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 377,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 502,
          "y" : 335
        },
        "to" : {
          "x" : 473,
          "y" : 353
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 357,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 505,
      "y" : 445
    },
    "minX" : 473,
    "maxX" : 522,
    "minY" : 421,
    "maxY" : 458,
    "prop" : {
      "x" : 489,
      "y" : 432,
      "width" : 32,
      "height" : 26
    },
    "textPosition" : {
      "x" : 495,
      "y" : 434
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 516,
          "y" : 437
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 516,
          "y" : 437
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 377,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 486,
          "y" : 433
        },
        "to" : {
          "x" : 473,
          "y" : 421
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 478,
          "y" : 431
        },
        "b" : {
          "x" : 486,
          "y" : 433
        },
        "c" : {
          "x" : 484,
          "y" : 425
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 484,
          "y" : 425
        }
      }
    } ]
  }, {
    "id" : 359,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1471,
      "y" : 521
    },
    "minX" : 1453,
    "maxX" : 1495,
    "minY" : 509,
    "maxY" : 563,
    "prop" : {
      "x" : 1453,
      "y" : 510,
      "width" : 36,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1461,
      "y" : 511
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1484,
          "y" : 515
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1484,
          "y" : 515
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 378,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1477,
          "y" : 536
        },
        "to" : {
          "x" : 1495,
          "y" : 563
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1484,
          "y" : 540
        },
        "b" : {
          "x" : 1477,
          "y" : 536
        },
        "c" : {
          "x" : 1478,
          "y" : 544
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1478,
          "y" : 544
        }
      }
    } ]
  }, {
    "id" : 1896,
    "reactomeId" : 198379,
    "displayName" : "PI3K alpha",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 352,
      "y" : 1189
    },
    "minX" : 317,
    "maxX" : 394,
    "minY" : 1151,
    "maxY" : 1200,
    "prop" : {
      "x" : 317,
      "y" : 1178,
      "width" : 71,
      "height" : 22
    },
    "textPosition" : {
      "x" : 331,
      "y" : 1165
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 388,
          "y" : 1178
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 388,
          "y" : 1178
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1895,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 342,
          "y" : 1175
        },
        "to" : {
          "x" : 318,
          "y" : 1151
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1897,
    "reactomeId" : 9615275,
    "displayName" : "RAC1:GTP,RAC2:GTP,RHOG:GTP",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 288,
      "y" : 1245
    },
    "minX" : 248,
    "maxX" : 329,
    "minY" : 1151,
    "maxY" : 1268,
    "prop" : {
      "x" : 248,
      "y" : 1222,
      "width" : 81,
      "height" : 46
    },
    "textPosition" : {
      "x" : 252,
      "y" : 1221
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "connectors" : [ {
      "edgeId" : 1895,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 295,
          "y" : 1216
        },
        "to" : {
          "x" : 318,
          "y" : 1151
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1898,
    "reactomeId" : 114540,
    "displayName" : "RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 277,
      "y" : 1017
    },
    "minX" : 237,
    "maxX" : 324,
    "minY" : 979,
    "maxY" : 1049,
    "prop" : {
      "x" : 237,
      "y" : 985,
      "width" : 81,
      "height" : 64
    },
    "textPosition" : {
      "x" : 240,
      "y" : 986
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 318,
          "y" : 985
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 318,
          "y" : 985
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1895,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 392,
    "reactomeId" : 202088,
    "displayName" : "AKT",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 517,
      "y" : 236
    },
    "minX" : 460,
    "maxX" : 534,
    "minY" : 192,
    "maxY" : 247,
    "prop" : {
      "x" : 501,
      "y" : 225,
      "width" : 33,
      "height" : 22
    },
    "textPosition" : {
      "x" : 502,
      "y" : 225
    },
    "connectors" : [ {
      "edgeId" : 582,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 502,
          "y" : 219
        },
        "to" : {
          "x" : 460,
          "y" : 192
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1163,
    "reactomeId" : 198615,
    "displayName" : "p-T23-CHUK",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2274,
      "y" : 866
    },
    "minX" : 2145,
    "maxX" : 2329,
    "minY" : 813,
    "maxY" : 877,
    "prop" : {
      "x" : 2226,
      "y" : 855,
      "width" : 97,
      "height" : 22
    },
    "innerProp" : {
      "x" : 2226,
      "y" : 861,
      "width" : 97,
      "height" : 16
    },
    "textPosition" : {
      "x" : 2234,
      "y" : 855
    },
    "nodeAttachments" : [ {
      "reactomeId" : 198597,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 23",
      "shape" : {
        "a" : {
          "x" : 2236,
          "y" : 849
        },
        "b" : {
          "x" : 2248,
          "y" : 861
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 2242,
          "y" : 855
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2323,
          "y" : 855
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2323,
          "y" : 855
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 364,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2247,
          "y" : 852
        },
        "to" : {
          "x" : 2145,
          "y" : 813
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2239,
          "y" : 853
        },
        "b" : {
          "x" : 2247,
          "y" : 852
        },
        "c" : {
          "x" : 2242,
          "y" : 846
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2242,
          "y" : 846
        }
      }
    } ]
  }, {
    "id" : 1692,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1581,
      "y" : 1358
    },
    "minX" : 1561,
    "maxX" : 1617,
    "minY" : 1334,
    "maxY" : 1370,
    "prop" : {
      "x" : 1561,
      "y" : 1347,
      "width" : 41,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1566,
      "y" : 1348
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1597,
          "y" : 1352
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1597,
          "y" : 1352
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1691,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1598,
          "y" : 1344
        },
        "to" : {
          "x" : 1617,
          "y" : 1334
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1693,
    "reactomeId" : 196206,
    "displayName" : "PP2A",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1585,
      "y" : 1310
    },
    "minX" : 1562,
    "maxX" : 1617,
    "minY" : 1293,
    "maxY" : 1334,
    "prop" : {
      "x" : 1562,
      "y" : 1299,
      "width" : 46,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1565,
      "y" : 1300
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1608,
          "y" : 1299
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1608,
          "y" : 1299
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1691,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1599,
          "y" : 1324
        },
        "to" : {
          "x" : 1617,
          "y" : 1334
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1694,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1708,
      "y" : 1358
    },
    "minX" : 1678,
    "maxX" : 1729,
    "minY" : 1334,
    "maxY" : 1369,
    "prop" : {
      "x" : 1688,
      "y" : 1347,
      "width" : 40,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1691,
      "y" : 1347
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1723,
          "y" : 1352
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1723,
          "y" : 1352
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1691,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1694,
          "y" : 1344
        },
        "to" : {
          "x" : 1678,
          "y" : 1334
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1686,
          "y" : 1344
        },
        "b" : {
          "x" : 1694,
          "y" : 1344
        },
        "c" : {
          "x" : 1690,
          "y" : 1337
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1690,
          "y" : 1337
        }
      }
    } ]
  }, {
    "id" : 1695,
    "reactomeId" : 8857938,
    "displayName" : "p-Y307-PP2A",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1706,
      "y" : 1306
    },
    "minX" : 1657,
    "maxX" : 1761,
    "minY" : 1290,
    "maxY" : 1334,
    "prop" : {
      "x" : 1657,
      "y" : 1296,
      "width" : 98,
      "height" : 20
    },
    "textPosition" : {
      "x" : 1662,
      "y" : 1295
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1755,
          "y" : 1296
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1755,
          "y" : 1296
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1691,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1696,
          "y" : 1319
        },
        "to" : {
          "x" : 1678,
          "y" : 1334
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1693,
          "y" : 1327
        },
        "b" : {
          "x" : 1696,
          "y" : 1319
        },
        "c" : {
          "x" : 1688,
          "y" : 1320
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1688,
          "y" : 1320
        }
      }
    } ]
  }, {
    "id" : 1696,
    "reactomeId" : 8857936,
    "displayName" : "Activated SRC,LCK,EGFR,INSR",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1649,
      "y" : 1431
    },
    "minX" : 1618,
    "maxX" : 1681,
    "minY" : 1342,
    "maxY" : 1467,
    "prop" : {
      "x" : 1618,
      "y" : 1396,
      "width" : 63,
      "height" : 71
    },
    "textPosition" : {
      "x" : 1620,
      "y" : 1393
    },
    "connectors" : [ {
      "edgeId" : 1691,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1649,
          "y" : 1390
        },
        "to" : {
          "x" : 1649,
          "y" : 1350
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1649,
          "y" : 1346
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1649,
          "y" : 1346
        }
      }
    } ]
  }, {
    "id" : 1698,
    "reactomeId" : 182504,
    "displayName" : "CDKN1A,CDKN1B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1804,
      "y" : 416
    },
    "minX" : 1767,
    "maxX" : 1871,
    "minY" : 401,
    "maxY" : 474,
    "prop" : {
      "x" : 1767,
      "y" : 401,
      "width" : 75,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1774,
      "y" : 399
    },
    "connectors" : [ {
      "edgeId" : 368,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1821,
          "y" : 437
        },
        "to" : {
          "x" : 1871,
          "y" : 474
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 420,
    "reactomeId" : 202210,
    "displayName" : "PDPK1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 392,
      "y" : 188
    },
    "minX" : 237,
    "maxX" : 425,
    "minY" : 170,
    "maxY" : 230,
    "prop" : {
      "x" : 366,
      "y" : 176,
      "width" : 53,
      "height" : 25
    },
    "textPosition" : {
      "x" : 368,
      "y" : 178
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 419,
          "y" : 176
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 419,
          "y" : 176
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 536,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 363,
          "y" : 183
        },
        "to" : {
          "x" : 333,
          "y" : 178
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 419,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 363,
          "y" : 195
        },
        "to" : {
          "x" : 237,
          "y" : 230
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 421,
    "reactomeId" : 2219520,
    "displayName" : "PDPK1:PIP2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1191,
      "y" : 106
    },
    "minX" : 1151,
    "maxX" : 1237,
    "minY" : 89,
    "maxY" : 117,
    "prop" : {
      "x" : 1151,
      "y" : 95,
      "width" : 80,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1151,
      "y" : 96
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1231,
          "y" : 95
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1231,
          "y" : 95
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 419,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1962,
    "reactomeId" : 57033,
    "displayName" : "CASP9(1-416)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2285,
      "y" : 560
    },
    "minX" : 2125,
    "maxX" : 2338,
    "minY" : 543,
    "maxY" : 618,
    "prop" : {
      "x" : 2239,
      "y" : 549,
      "width" : 93,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2253,
      "y" : 543
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2332,
          "y" : 549
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2332,
          "y" : 549
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 366,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2253,
          "y" : 575
        },
        "to" : {
          "x" : 2125,
          "y" : 618
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1963,
    "reactomeId" : 9755778,
    "displayName" : "N:M:PDPK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1687,
      "y" : 238
    },
    "isDisease" : true,
    "minX" : 1634,
    "maxX" : 1731,
    "minY" : 210,
    "maxY" : 250,
    "prop" : {
      "x" : 1650,
      "y" : 227,
      "width" : 75,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1650,
      "y" : 229
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1725,
          "y" : 227
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1725,
          "y" : 227
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 362,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1664,
          "y" : 224
        },
        "to" : {
          "x" : 1642,
          "y" : 215
        }
      }, {
        "from" : {
          "x" : 1642,
          "y" : 215
        },
        "to" : {
          "x" : 1634,
          "y" : 214
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1634,
          "y" : 218
        },
        "b" : {
          "x" : 1634,
          "y" : 210
        },
        "c" : {
          "x" : 1634,
          "y" : 214
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1634,
          "y" : 214
        }
      }
    } ]
  }, {
    "id" : 1968,
    "reactomeId" : 9705683,
    "displayName" : "SARS-CoV-2-host interactions",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1820,
      "y" : 238
    },
    "isDisease" : true,
    "minX" : 1758,
    "maxX" : 1883,
    "minY" : 216,
    "maxY" : 261,
    "prop" : {
      "x" : 1758,
      "y" : 216,
      "width" : 125,
      "height" : 45
    },
    "textPosition" : {
      "x" : 1758,
      "y" : 217
    },
    "connectors" : [ ]
  }, {
    "id" : 1717,
    "reactomeId" : 6806834,
    "displayName" : "Signaling by MET",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 73,
      "y" : 660
    },
    "minX" : 1,
    "maxX" : 145,
    "minY" : 633,
    "maxY" : 687,
    "prop" : {
      "x" : 1,
      "y" : 633,
      "width" : 144,
      "height" : 54
    },
    "textPosition" : {
      "x" : 13,
      "y" : 645
    },
    "connectors" : [ ]
  }, {
    "id" : 1977,
    "reactomeId" : 2682356,
    "displayName" : "SGK1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 737,
      "y" : 375
    },
    "minX" : 717,
    "maxX" : 814,
    "minY" : 358,
    "maxY" : 386,
    "prop" : {
      "x" : 717,
      "y" : 364,
      "width" : 40,
      "height" : 22
    },
    "textPosition" : {
      "x" : 717,
      "y" : 364
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 757,
          "y" : 364
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 757,
          "y" : 364
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1975,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 760,
          "y" : 375
        },
        "to" : {
          "x" : 814,
          "y" : 378
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1978,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 944,
      "y" : 430
    },
    "minX" : 895,
    "maxX" : 963,
    "minY" : 374,
    "maxY" : 444,
    "prop" : {
      "x" : 926,
      "y" : 416,
      "width" : 36,
      "height" : 28
    },
    "textPosition" : {
      "x" : 927,
      "y" : 419
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 957,
          "y" : 421
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 957,
          "y" : 421
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1975,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 931,
          "y" : 413
        },
        "to" : {
          "x" : 895,
          "y" : 374
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 923,
          "y" : 411
        },
        "b" : {
          "x" : 931,
          "y" : 413
        },
        "c" : {
          "x" : 929,
          "y" : 405
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 929,
          "y" : 405
        }
      }
    } ]
  }, {
    "id" : 1979,
    "reactomeId" : 6795313,
    "displayName" : "p-S422-SGK1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1003,
      "y" : 375
    },
    "minX" : 895,
    "maxX" : 1076,
    "minY" : 333,
    "maxY" : 389,
    "prop" : {
      "x" : 950,
      "y" : 361,
      "width" : 106,
      "height" : 28
    },
    "innerProp" : {
      "x" : 950,
      "y" : 367,
      "width" : 106,
      "height" : 22
    },
    "textPosition" : {
      "x" : 959,
      "y" : 364
    },
    "nodeAttachments" : [ {
      "reactomeId" : 6795307,
      "label" : "P",
      "description" : "O-phospho-L-serine at 422",
      "shape" : {
        "a" : {
          "x" : 960,
          "y" : 355
        },
        "b" : {
          "x" : 972,
          "y" : 367
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 966,
          "y" : 361
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1056,
          "y" : 361
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1056,
          "y" : 361
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1988,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1027,
          "y" : 358
        },
        "to" : {
          "x" : 1076,
          "y" : 333
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1975,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 947,
          "y" : 374
        },
        "to" : {
          "x" : 895,
          "y" : 374
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 940,
          "y" : 378
        },
        "b" : {
          "x" : 947,
          "y" : 374
        },
        "c" : {
          "x" : 940,
          "y" : 370
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 940,
          "y" : 370
        }
      }
    } ]
  }, {
    "id" : 1989,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1102,
      "y" : 417
    },
    "minX" : 1076,
    "maxX" : 1123,
    "minY" : 333,
    "maxY" : 432,
    "prop" : {
      "x" : 1082,
      "y" : 402,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1086,
      "y" : 406
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1117,
          "y" : 407
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1117,
          "y" : 407
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1988,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1097,
          "y" : 399
        },
        "to" : {
          "x" : 1076,
          "y" : 333
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1990,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1252,
      "y" : 260
    },
    "minX" : 1188,
    "maxX" : 1274,
    "minY" : 244,
    "maxY" : 275,
    "prop" : {
      "x" : 1232,
      "y" : 245,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1236,
      "y" : 249
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1268,
          "y" : 250
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1268,
          "y" : 250
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1988,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1229,
          "y" : 262
        },
        "to" : {
          "x" : 1188,
          "y" : 267
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1223,
          "y" : 267
        },
        "b" : {
          "x" : 1229,
          "y" : 262
        },
        "c" : {
          "x" : 1222,
          "y" : 259
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1222,
          "y" : 259
        }
      }
    } ]
  }, {
    "id" : 1991,
    "reactomeId" : 6795449,
    "displayName" : "p-T256,S422-SGK1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1173,
      "y" : 217
    },
    "minX" : 1096,
    "maxX" : 1250,
    "minY" : 198,
    "maxY" : 267,
    "prop" : {
      "x" : 1102,
      "y" : 204,
      "width" : 142,
      "height" : 26
    },
    "innerProp" : {
      "x" : 1108,
      "y" : 210,
      "width" : 136,
      "height" : 20
    },
    "textPosition" : {
      "x" : 1111,
      "y" : 206
    },
    "nodeAttachments" : [ {
      "reactomeId" : 6795307,
      "label" : "P",
      "description" : "O-phospho-L-serine at 422",
      "shape" : {
        "a" : {
          "x" : 1096,
          "y" : 198
        },
        "b" : {
          "x" : 1108,
          "y" : 210
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1102,
          "y" : 204
        }
      }
    }, {
      "reactomeId" : 6795466,
      "label" : "P",
      "description" : "O-phospho-L-threonine at 256",
      "shape" : {
        "a" : {
          "x" : 1096,
          "y" : 216
        },
        "b" : {
          "x" : 1108,
          "y" : 228
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1102,
          "y" : 222
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1244,
          "y" : 204
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1244,
          "y" : 204
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1988,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1176,
          "y" : 233
        },
        "to" : {
          "x" : 1188,
          "y" : 267
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1182,
          "y" : 238
        },
        "b" : {
          "x" : 1176,
          "y" : 233
        },
        "c" : {
          "x" : 1175,
          "y" : 241
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1175,
          "y" : 241
        }
      }
    } ]
  }, {
    "id" : 1998,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 782,
      "y" : 416
    },
    "minX" : 764,
    "maxX" : 814,
    "minY" : 378,
    "maxY" : 428,
    "prop" : {
      "x" : 764,
      "y" : 405,
      "width" : 36,
      "height" : 23
    },
    "textPosition" : {
      "x" : 766,
      "y" : 406
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 795,
          "y" : 410
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 795,
          "y" : 410
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1975,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 791,
          "y" : 402
        },
        "to" : {
          "x" : 814,
          "y" : 378
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1743,
    "reactomeId" : 202403,
    "displayName" : "TCR signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 71,
      "y" : 724
    },
    "minX" : 0,
    "maxX" : 143,
    "minY" : 699,
    "maxY" : 750,
    "prop" : {
      "x" : 0,
      "y" : 699,
      "width" : 143,
      "height" : 51
    },
    "textPosition" : {
      "x" : 22,
      "y" : 710
    },
    "connectors" : [ ]
  }, {
    "id" : 1242,
    "reactomeId" : 198636,
    "displayName" : "p-S196-CASP9(1-416)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2227,
      "y" : 907
    },
    "minX" : 2125,
    "maxX" : 2309,
    "minY" : 839,
    "maxY" : 921,
    "prop" : {
      "x" : 2151,
      "y" : 893,
      "width" : 152,
      "height" : 28
    },
    "innerProp" : {
      "x" : 2151,
      "y" : 899,
      "width" : 152,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2156,
      "y" : 896
    },
    "nodeAttachments" : [ {
      "reactomeId" : 198639,
      "label" : "P",
      "description" : "O-phospho-L-serine at 196",
      "shape" : {
        "a" : {
          "x" : 2161,
          "y" : 887
        },
        "b" : {
          "x" : 2173,
          "y" : 899
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 2167,
          "y" : 893
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2303,
          "y" : 893
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2303,
          "y" : 893
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 366,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2206,
          "y" : 890
        },
        "to" : {
          "x" : 2125,
          "y" : 839
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2198,
          "y" : 890
        },
        "b" : {
          "x" : 2206,
          "y" : 890
        },
        "c" : {
          "x" : 2202,
          "y" : 883
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2202,
          "y" : 883
        }
      }
    } ]
  }, {
    "id" : 1763,
    "reactomeId" : 165159,
    "displayName" : "MTOR signalling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 2247,
      "y" : 393
    },
    "minX" : 2179,
    "maxX" : 2315,
    "minY" : 371,
    "maxY" : 416,
    "prop" : {
      "x" : 2179,
      "y" : 371,
      "width" : 136,
      "height" : 45
    },
    "textPosition" : {
      "x" : 2190,
      "y" : 379
    },
    "connectors" : [ ]
  }, {
    "id" : 1769,
    "reactomeId" : 6806003,
    "displayName" : "Regulation of TP53 Expression and Degradation",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 2358,
      "y" : 975
    },
    "minX" : 2279,
    "maxX" : 2438,
    "minY" : 940,
    "maxY" : 1010,
    "prop" : {
      "x" : 2279,
      "y" : 940,
      "width" : 159,
      "height" : 70
    },
    "textPosition" : {
      "x" : 2289,
      "y" : 946
    },
    "connectors" : [ ]
  }, {
    "id" : 1001,
    "reactomeId" : 111910,
    "displayName" : "p-S133-CREB1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1266,
      "y" : 1120
    },
    "minX" : 1210,
    "maxX" : 1305,
    "minY" : 1092,
    "maxY" : 1140,
    "prop" : {
      "x" : 1234,
      "y" : 1101,
      "width" : 65,
      "height" : 39
    },
    "innerProp" : {
      "x" : 1234,
      "y" : 1107,
      "width" : 65,
      "height" : 33
    },
    "textPosition" : {
      "x" : 1238,
      "y" : 1103
    },
    "nodeAttachments" : [ {
      "reactomeId" : 111909,
      "label" : "P",
      "description" : "O-phospho-L-serine at 133",
      "shape" : {
        "a" : {
          "x" : 1244,
          "y" : 1095
        },
        "b" : {
          "x" : 1256,
          "y" : 1107
        },
        "s" : "P",
        "type" : "BOX",
        "empty" : true,
        "centre" : {
          "x" : 1250,
          "y" : 1101
        }
      }
    } ],
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1299,
          "y" : 1101
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1299,
          "y" : 1101
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 372,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1231,
          "y" : 1103
        },
        "to" : {
          "x" : 1210,
          "y" : 1092
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1223,
          "y" : 1103
        },
        "b" : {
          "x" : 1231,
          "y" : 1103
        },
        "c" : {
          "x" : 1227,
          "y" : 1096
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1227,
          "y" : 1096
        }
      }
    } ]
  }, {
    "id" : 498,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 384,
      "y" : 474
    },
    "minX" : 360,
    "maxX" : 406,
    "minY" : 440,
    "maxY" : 486,
    "prop" : {
      "x" : 364,
      "y" : 463,
      "width" : 41,
      "height" : 23
    },
    "textPosition" : {
      "x" : 369,
      "y" : 464
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 400,
          "y" : 468
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 400,
          "y" : 468
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 497,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 375,
          "y" : 460
        },
        "to" : {
          "x" : 360,
          "y" : 440
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 499,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 393,
      "y" : 337
    },
    "minX" : 361,
    "maxX" : 415,
    "minY" : 323,
    "maxY" : 371,
    "prop" : {
      "x" : 373,
      "y" : 324,
      "width" : 41,
      "height" : 26
    },
    "textPosition" : {
      "x" : 377,
      "y" : 326
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 409,
          "y" : 329
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 409,
          "y" : 329
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 497,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 380,
          "y" : 353
        },
        "to" : {
          "x" : 361,
          "y" : 371
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 378,
          "y" : 361
        },
        "b" : {
          "x" : 380,
          "y" : 353
        },
        "c" : {
          "x" : 372,
          "y" : 355
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 372,
          "y" : 355
        }
      }
    } ]
  }, {
    "id" : 500,
    "reactomeId" : 2316432,
    "displayName" : "Activator:PI3K",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 290,
      "y" : 408
    },
    "minX" : 257,
    "maxX" : 352,
    "minY" : 390,
    "maxY" : 427,
    "prop" : {
      "x" : 257,
      "y" : 390,
      "width" : 67,
      "height" : 37
    },
    "textPosition" : {
      "x" : 257,
      "y" : 391
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 497,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 330,
          "y" : 407
        },
        "to" : {
          "x" : 344,
          "y" : 407
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 348,
          "y" : 406
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 348,
          "y" : 406
        }
      }
    } ]
  }, {
    "id" : 1527,
    "reactomeId" : 392417,
    "displayName" : "PI4P",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 290,
      "y" : 1405
    },
    "minX" : 264,
    "maxX" : 440,
    "minY" : 1344,
    "maxY" : 1420,
    "prop" : {
      "x" : 264,
      "y" : 1390,
      "width" : 52,
      "height" : 30
    },
    "textPosition" : {
      "x" : 272,
      "y" : 1394
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 311,
          "y" : 1395
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 311,
          "y" : 1395
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1526,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 319,
          "y" : 1394
        },
        "to" : {
          "x" : 440,
          "y" : 1344
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1530,
    "reactomeId" : 1806157,
    "displayName" : "PIP5K1A-C",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 548,
      "y" : 1282
    },
    "minX" : 446,
    "maxX" : 586,
    "minY" : 1271,
    "maxY" : 1293,
    "prop" : {
      "x" : 511,
      "y" : 1271,
      "width" : 75,
      "height" : 22
    },
    "textPosition" : {
      "x" : 513,
      "y" : 1271
    },
    "connectors" : [ {
      "edgeId" : 1526,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 505,
          "y" : 1282
        },
        "to" : {
          "x" : 454,
          "y" : 1282
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 450,
          "y" : 1282
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 450,
          "y" : 1282
        }
      }
    } ]
  }, {
    "id" : 1532,
    "reactomeId" : 1806240,
    "displayName" : "PI5P",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1463,
      "y" : 1442
    },
    "minX" : 488,
    "maxX" : 1794,
    "minY" : 1250,
    "maxY" : 1456,
    "prop" : {
      "x" : 1438,
      "y" : 1429,
      "width" : 51,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1446,
      "y" : 1432
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1484,
          "y" : 1434
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1484,
          "y" : 1434
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1545,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1469,
          "y" : 1426
        },
        "to" : {
          "x" : 1552,
          "y" : 1254
        }
      }, {
        "from" : {
          "x" : 1552,
          "y" : 1254
        },
        "to" : {
          "x" : 1794,
          "y" : 1254
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1794,
          "y" : 1258
        },
        "b" : {
          "x" : 1794,
          "y" : 1250
        },
        "c" : {
          "x" : 1794,
          "y" : 1254
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1794,
          "y" : 1254
        }
      }
    }, {
      "edgeId" : 1691,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1492,
          "y" : 1432
        },
        "to" : {
          "x" : 1605,
          "y" : 1388
        }
      }, {
        "from" : {
          "x" : 1605,
          "y" : 1388
        },
        "to" : {
          "x" : 1643,
          "y" : 1341
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1642,
          "y" : 1349
        },
        "b" : {
          "x" : 1643,
          "y" : 1341
        },
        "c" : {
          "x" : 1636,
          "y" : 1344
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1636,
          "y" : 1344
        }
      }
    }, {
      "edgeId" : 1531,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1435,
          "y" : 1441
        },
        "to" : {
          "x" : 607,
          "y" : 1411
        }
      }, {
        "from" : {
          "x" : 607,
          "y" : 1411
        },
        "to" : {
          "x" : 488,
          "y" : 1330
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1533,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 379,
      "y" : 1410
    },
    "minX" : 357,
    "maxX" : 488,
    "minY" : 1330,
    "maxY" : 1422,
    "prop" : {
      "x" : 357,
      "y" : 1399,
      "width" : 44,
      "height" : 23
    },
    "textPosition" : {
      "x" : 363,
      "y" : 1400
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 396,
          "y" : 1404
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 396,
          "y" : 1404
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1526,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 389,
          "y" : 1396
        },
        "to" : {
          "x" : 440,
          "y" : 1344
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 1531,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 394,
          "y" : 1396
        },
        "to" : {
          "x" : 488,
          "y" : 1330
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 1534,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 524,
      "y" : 1072
    },
    "minX" : 439,
    "maxX" : 547,
    "minY" : 1057,
    "maxY" : 1165,
    "prop" : {
      "x" : 503,
      "y" : 1058,
      "width" : 43,
      "height" : 28
    },
    "textPosition" : {
      "x" : 508,
      "y" : 1061
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 541,
          "y" : 1063
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 541,
          "y" : 1063
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 1526,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 511,
          "y" : 1089
        },
        "to" : {
          "x" : 439,
          "y" : 1165
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 509,
          "y" : 1097
        },
        "b" : {
          "x" : 511,
          "y" : 1089
        },
        "c" : {
          "x" : 503,
          "y" : 1091
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 503,
          "y" : 1091
        }
      }
    }, {
      "edgeId" : 1531,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 510,
          "y" : 1089
        },
        "to" : {
          "x" : 488,
          "y" : 1108
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 507,
          "y" : 1097
        },
        "b" : {
          "x" : 510,
          "y" : 1089
        },
        "c" : {
          "x" : 502,
          "y" : 1091
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 502,
          "y" : 1091
        }
      }
    } ]
  }, {
    "id" : 1535,
    "reactomeId" : 1806229,
    "displayName" : "PIP4K2 dimers",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 569,
      "y" : 1202
    },
    "minX" : 494,
    "maxX" : 617,
    "minY" : 1189,
    "maxY" : 1252,
    "prop" : {
      "x" : 522,
      "y" : 1189,
      "width" : 95,
      "height" : 27
    },
    "textPosition" : {
      "x" : 542,
      "y" : 1185
    },
    "connectors" : [ {
      "edgeId" : 1531,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 547,
          "y" : 1222
        },
        "to" : {
          "x" : 501,
          "y" : 1246
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 498,
          "y" : 1248
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 498,
          "y" : 1248
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 1988,
    "reactomeId" : 6795473,
    "displayName" : "PDPK1 phosphorylates SGK1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1148,
      "y" : 352
    },
    "minX" : 1076,
    "maxX" : 1188,
    "minY" : 267,
    "maxY" : 358,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1076,
        "y" : 333
      },
      "to" : {
        "x" : 1148,
        "y" : 352
      }
    }, {
      "from" : {
        "x" : 1148,
        "y" : 352
      },
      "to" : {
        "x" : 1188,
        "y" : 267
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1142,
        "y" : 346
      },
      "b" : {
        "x" : 1154,
        "y" : 358
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1148,
        "y" : 352
      }
    },
    "inputs" : [ {
      "id" : 1989,
      "points" : [ {
        "x" : 1097,
        "y" : 399
      } ]
    }, {
      "id" : 1979,
      "points" : [ {
        "x" : 1027,
        "y" : 358
      } ]
    } ],
    "outputs" : [ {
      "id" : 1990,
      "points" : [ {
        "x" : 1229,
        "y" : 262
      } ]
    }, {
      "id" : 1991,
      "points" : [ {
        "x" : 1176,
        "y" : 233
      } ]
    } ],
    "catalysts" : [ {
      "id" : 537,
      "points" : [ {
        "x" : 1507,
        "y" : 121
      }, {
        "x" : 1472,
        "y" : 354
      } ]
    } ]
  }, {
    "id" : 582,
    "reactomeId" : 2317332,
    "displayName" : "PIP3 recruits AKT to the membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 456,
      "y" : 156
    },
    "minX" : 451,
    "maxX" : 461,
    "minY" : 125,
    "maxY" : 192,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 460,
        "y" : 192
      },
      "to" : {
        "x" : 456,
        "y" : 156
      }
    }, {
      "from" : {
        "x" : 456,
        "y" : 156
      },
      "to" : {
        "x" : 456,
        "y" : 125
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 460,
        "y" : 132
      },
      "b" : {
        "x" : 456,
        "y" : 125
      },
      "c" : {
        "x" : 452,
        "y" : 132
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 452,
        "y" : 132
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 456,
        "y" : 156
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 456,
        "y" : 156
      }
    },
    "inputs" : [ {
      "id" : 313,
      "points" : [ {
        "x" : 334,
        "y" : 241
      } ]
    }, {
      "id" : 392,
      "points" : [ {
        "x" : 502,
        "y" : 219
      } ]
    } ],
    "outputs" : [ {
      "id" : 574
    } ]
  }, {
    "id" : 1863,
    "reactomeId" : 8948757,
    "displayName" : "AKT phosphorylates MKRN1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1912,
      "y" : 603
    },
    "minX" : 1906,
    "maxX" : 1918,
    "minY" : 530,
    "maxY" : 820,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1911,
        "y" : 530
      },
      "to" : {
        "x" : 1912,
        "y" : 603
      }
    }, {
      "from" : {
        "x" : 1912,
        "y" : 603
      },
      "to" : {
        "x" : 1910,
        "y" : 820
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1906,
        "y" : 597
      },
      "b" : {
        "x" : 1918,
        "y" : 609
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1912,
        "y" : 603
      }
    },
    "inputs" : [ {
      "id" : 1865,
      "points" : [ {
        "x" : 1810,
        "y" : 475
      } ]
    }, {
      "id" : 320,
      "points" : [ {
        "x" : 1987,
        "y" : 533
      } ]
    } ],
    "outputs" : [ {
      "id" : 1867,
      "points" : [ {
        "x" : 1762,
        "y" : 873
      } ]
    }, {
      "id" : 332,
      "points" : [ {
        "x" : 1991,
        "y" : 803
      } ]
    } ],
    "catalysts" : [ {
      "id" : 312,
      "points" : [ {
        "x" : 1678,
        "y" : 608
      } ]
    } ]
  }, {
    "id" : 1545,
    "reactomeId" : 6811504,
    "displayName" : "AKT1 dephosphorylation by PP2A-B56-beta,gamma",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1803,
      "y" : 1254
    },
    "minX" : 1797,
    "maxX" : 1809,
    "minY" : 1207,
    "maxY" : 1319,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1802,
        "y" : 1207
      },
      "to" : {
        "x" : 1803,
        "y" : 1254
      }
    }, {
      "from" : {
        "x" : 1803,
        "y" : 1254
      },
      "to" : {
        "x" : 1803,
        "y" : 1319
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1797,
        "y" : 1248
      },
      "b" : {
        "x" : 1809,
        "y" : 1260
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1803,
        "y" : 1254
      }
    },
    "inputs" : [ {
      "id" : 1546,
      "points" : [ {
        "x" : 1842,
        "y" : 1184
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 1547,
      "points" : [ {
        "x" : 1774,
        "y" : 1189
      } ]
    } ],
    "outputs" : [ {
      "id" : 1549,
      "points" : [ {
        "x" : 1786,
        "y" : 1374
      } ]
    }, {
      "id" : 1553,
      "points" : [ {
        "x" : 1846,
        "y" : 1372
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 1551,
      "points" : [ {
        "x" : 1863,
        "y" : 1251
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 1532,
      "points" : [ {
        "x" : 1469,
        "y" : 1426
      }, {
        "x" : 1552,
        "y" : 1254
      } ]
    } ]
  }, {
    "id" : 1556,
    "reactomeId" : 6811472,
    "displayName" : "IER3 recruits MAPKs to PP2A-B56-beta,gamma",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2033,
      "y" : 1302
    },
    "minX" : 2028,
    "maxX" : 2038,
    "minY" : 1268,
    "maxY" : 1354,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2034,
        "y" : 1268
      },
      "to" : {
        "x" : 2033,
        "y" : 1302
      }
    }, {
      "from" : {
        "x" : 2033,
        "y" : 1302
      },
      "to" : {
        "x" : 2033,
        "y" : 1354
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2029,
        "y" : 1347
      },
      "b" : {
        "x" : 2033,
        "y" : 1354
      },
      "c" : {
        "x" : 2037,
        "y" : 1347
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2037,
        "y" : 1347
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2033,
        "y" : 1302
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2033,
        "y" : 1302
      }
    },
    "inputs" : [ {
      "id" : 1557,
      "points" : [ {
        "x" : 2034,
        "y" : 1206
      } ]
    }, {
      "id" : 1551,
      "points" : [ {
        "x" : 1969,
        "y" : 1257
      } ]
    }, {
      "id" : 1558,
      "points" : [ {
        "x" : 2058,
        "y" : 1259
      } ]
    } ],
    "outputs" : [ {
      "id" : 1559
    } ]
  }, {
    "id" : 1560,
    "reactomeId" : 6811454,
    "displayName" : "MAPKs phosphorylate PP2A",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2144,
      "y" : 1267
    },
    "minX" : 2138,
    "maxX" : 2150,
    "minY" : 1215,
    "maxY" : 1327,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2143,
        "y" : 1327
      },
      "to" : {
        "x" : 2144,
        "y" : 1267
      }
    }, {
      "from" : {
        "x" : 2144,
        "y" : 1267
      },
      "to" : {
        "x" : 2143,
        "y" : 1215
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2138,
        "y" : 1261
      },
      "b" : {
        "x" : 2150,
        "y" : 1273
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2144,
        "y" : 1267
      }
    },
    "inputs" : [ {
      "id" : 1561,
      "points" : [ {
        "x" : 2168,
        "y" : 1339
      } ]
    }, {
      "id" : 1559,
      "points" : [ {
        "x" : 2078,
        "y" : 1354
      } ]
    } ],
    "outputs" : [ {
      "id" : 1562,
      "points" : [ {
        "x" : 2179,
        "y" : 1107
      } ]
    }, {
      "id" : 1563,
      "points" : [ {
        "x" : 2106,
        "y" : 1146
      } ]
    }, {
      "id" : 1564,
      "points" : [ {
        "x" : 2180,
        "y" : 1193
      } ]
    }, {
      "id" : 1557,
      "points" : [ {
        "x" : 2087,
        "y" : 1206
      } ]
    }, {
      "id" : 1558,
      "points" : [ {
        "x" : 2097,
        "y" : 1239
      } ]
    } ],
    "catalysts" : [ {
      "id" : 1559,
      "points" : [ {
        "x" : 2047,
        "y" : 1354
      }, {
        "x" : 2112,
        "y" : 1267
      } ]
    } ]
  }, {
    "id" : 536,
    "reactomeId" : 2316429,
    "displayName" : "PIP3 recruits PDPK1 to the membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 355,
      "y" : 142
    },
    "minX" : 333,
    "maxX" : 1495,
    "minY" : 0,
    "maxY" : 178,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 333,
        "y" : 178
      },
      "to" : {
        "x" : 355,
        "y" : 142
      }
    }, {
      "from" : {
        "x" : 355,
        "y" : 142
      },
      "to" : {
        "x" : 390,
        "y" : 19
      }
    }, {
      "from" : {
        "x" : 390,
        "y" : 19
      },
      "to" : {
        "x" : 1379,
        "y" : 0
      }
    }, {
      "from" : {
        "x" : 1379,
        "y" : 0
      },
      "to" : {
        "x" : 1495,
        "y" : 93
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1487,
        "y" : 92
      },
      "b" : {
        "x" : 1495,
        "y" : 93
      },
      "c" : {
        "x" : 1492,
        "y" : 86
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1492,
        "y" : 86
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 355,
        "y" : 142
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 355,
        "y" : 142
      }
    },
    "inputs" : [ {
      "id" : 420,
      "points" : [ {
        "x" : 363,
        "y" : 183
      } ]
    }, {
      "id" : 313,
      "points" : [ {
        "x" : 302,
        "y" : 237
      } ]
    } ],
    "outputs" : [ {
      "id" : 537
    } ]
  }, {
    "id" : 1691,
    "reactomeId" : 8857925,
    "displayName" : "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1649,
      "y" : 1334
    },
    "minX" : 1617,
    "maxX" : 1678,
    "minY" : 1328,
    "maxY" : 1340,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1617,
        "y" : 1334
      },
      "to" : {
        "x" : 1649,
        "y" : 1334
      }
    }, {
      "from" : {
        "x" : 1649,
        "y" : 1334
      },
      "to" : {
        "x" : 1678,
        "y" : 1334
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1643,
        "y" : 1328
      },
      "b" : {
        "x" : 1655,
        "y" : 1340
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1649,
        "y" : 1334
      }
    },
    "inputs" : [ {
      "id" : 1692,
      "points" : [ {
        "x" : 1598,
        "y" : 1344
      } ]
    }, {
      "id" : 1693,
      "points" : [ {
        "x" : 1599,
        "y" : 1324
      } ]
    } ],
    "outputs" : [ {
      "id" : 1694,
      "points" : [ {
        "x" : 1694,
        "y" : 1344
      } ]
    }, {
      "id" : 1695,
      "points" : [ {
        "x" : 1696,
        "y" : 1319
      } ]
    } ],
    "catalysts" : [ {
      "id" : 1696,
      "points" : [ {
        "x" : 1649,
        "y" : 1390
      } ]
    } ],
    "activators" : [ {
      "id" : 1532,
      "points" : [ {
        "x" : 1492,
        "y" : 1432
      }, {
        "x" : 1605,
        "y" : 1388
      } ]
    } ]
  }, {
    "id" : 544,
    "reactomeId" : 2317314,
    "displayName" : "AKT binds PDPK1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1560,
      "y" : 45
    },
    "minX" : 1488,
    "maxX" : 1663,
    "minY" : 40,
    "maxY" : 99,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1488,
        "y" : 47
      },
      "to" : {
        "x" : 1560,
        "y" : 45
      }
    }, {
      "from" : {
        "x" : 1560,
        "y" : 45
      },
      "to" : {
        "x" : 1663,
        "y" : 99
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1655,
        "y" : 99
      },
      "b" : {
        "x" : 1663,
        "y" : 99
      },
      "c" : {
        "x" : 1659,
        "y" : 92
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1659,
        "y" : 92
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1560,
        "y" : 45
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1560,
        "y" : 45
      }
    },
    "inputs" : [ {
      "id" : 537,
      "points" : [ {
        "x" : 1505,
        "y" : 93
      } ]
    }, {
      "id" : 534,
      "points" : [ {
        "x" : 776,
        "y" : 94
      }, {
        "x" : 819,
        "y" : 50
      } ]
    } ],
    "outputs" : [ {
      "id" : 545
    } ]
  }, {
    "id" : 419,
    "reactomeId" : 2219524,
    "displayName" : "PDPK1 binds PIP2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1100,
      "y" : 25
    },
    "minX" : 237,
    "maxX" : 1178,
    "minY" : 20,
    "maxY" : 230,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 237,
        "y" : 230
      },
      "to" : {
        "x" : 278,
        "y" : 54
      }
    }, {
      "from" : {
        "x" : 278,
        "y" : 54
      },
      "to" : {
        "x" : 1100,
        "y" : 25
      }
    }, {
      "from" : {
        "x" : 1100,
        "y" : 25
      },
      "to" : {
        "x" : 1178,
        "y" : 92
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1170,
        "y" : 91
      },
      "b" : {
        "x" : 1178,
        "y" : 92
      },
      "c" : {
        "x" : 1175,
        "y" : 84
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1175,
        "y" : 84
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1100,
        "y" : 25
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1100,
        "y" : 25
      }
    },
    "inputs" : [ {
      "id" : 420,
      "points" : [ {
        "x" : 363,
        "y" : 195
      } ]
    }, {
      "id" : 353,
      "points" : [ {
        "x" : 277,
        "y" : 582
      }, {
        "x" : 210,
        "y" : 510
      } ]
    } ],
    "outputs" : [ {
      "id" : 421
    } ]
  }, {
    "id" : 1895,
    "reactomeId" : 114542,
    "displayName" : "RAC1,RAC2,RHOG activate PI3K",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 328,
      "y" : 1116
    },
    "minX" : 293,
    "maxX" : 333,
    "minY" : 1052,
    "maxY" : 1151,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 318,
        "y" : 1151
      },
      "to" : {
        "x" : 328,
        "y" : 1116
      }
    }, {
      "from" : {
        "x" : 328,
        "y" : 1116
      },
      "to" : {
        "x" : 293,
        "y" : 1052
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 300,
        "y" : 1056
      },
      "b" : {
        "x" : 293,
        "y" : 1052
      },
      "c" : {
        "x" : 293,
        "y" : 1060
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 293,
        "y" : 1060
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 328,
        "y" : 1116
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 328,
        "y" : 1116
      }
    },
    "inputs" : [ {
      "id" : 1896,
      "points" : [ {
        "x" : 342,
        "y" : 1175
      } ]
    }, {
      "id" : 1897,
      "points" : [ {
        "x" : 295,
        "y" : 1216
      } ]
    } ],
    "outputs" : [ {
      "id" : 1898
    } ]
  }, {
    "id" : 360,
    "reactomeId" : 198640,
    "displayName" : "mTORC2 phosphorylates AKT at S473",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 652,
      "y" : 174
    },
    "minX" : 627,
    "maxX" : 705,
    "minY" : 168,
    "maxY" : 180,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 627,
        "y" : 173
      },
      "to" : {
        "x" : 652,
        "y" : 174
      }
    }, {
      "from" : {
        "x" : 652,
        "y" : 174
      },
      "to" : {
        "x" : 705,
        "y" : 172
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 646,
        "y" : 168
      },
      "b" : {
        "x" : 658,
        "y" : 180
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 652,
        "y" : 174
      }
    },
    "inputs" : [ {
      "id" : 574,
      "points" : [ {
        "x" : 492,
        "y" : 121
      } ]
    }, {
      "id" : 576,
      "points" : [ {
        "x" : 616,
        "y" : 190
      } ]
    } ],
    "outputs" : [ {
      "id" : 534,
      "points" : [ {
        "x" : 754,
        "y" : 124
      } ]
    }, {
      "id" : 535,
      "points" : [ {
        "x" : 724,
        "y" : 187
      } ]
    } ],
    "catalysts" : [ {
      "id" : 2067,
      "points" : [ {
        "x" : 799,
        "y" : 161
      }, {
        "x" : 771,
        "y" : 225
      }, {
        "x" : 658,
        "y" : 214
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 347,
      "points" : [ {
        "x" : 658,
        "y" : 130
      } ]
    } ]
  }, {
    "id" : 362,
    "reactomeId" : 198270,
    "displayName" : "PDPK1 phosphorylates AKT at T308",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1625,
      "y" : 213
    },
    "minX" : 1619,
    "maxX" : 1631,
    "minY" : 172,
    "maxY" : 253,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1625,
        "y" : 172
      },
      "to" : {
        "x" : 1625,
        "y" : 213
      }
    }, {
      "from" : {
        "x" : 1625,
        "y" : 213
      },
      "to" : {
        "x" : 1626,
        "y" : 253
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1619,
        "y" : 207
      },
      "b" : {
        "x" : 1631,
        "y" : 219
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1625,
        "y" : 213
      }
    },
    "inputs" : [ {
      "id" : 548,
      "points" : [ {
        "x" : 1605,
        "y" : 168
      } ]
    }, {
      "id" : 545,
      "points" : [ {
        "x" : 1672,
        "y" : 128
      } ]
    } ],
    "outputs" : [ {
      "id" : 537,
      "points" : [ {
        "x" : 1517,
        "y" : 121
      } ]
    }, {
      "id" : 312,
      "points" : [ {
        "x" : 1625,
        "y" : 589
      } ]
    }, {
      "id" : 551,
      "points" : [ {
        "x" : 1597,
        "y" : 270
      } ]
    } ],
    "catalysts" : [ {
      "id" : 545,
      "points" : [ {
        "x" : 1679,
        "y" : 128
      }, {
        "x" : 1648,
        "y" : 196
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 1963,
      "points" : [ {
        "x" : 1664,
        "y" : 224
      }, {
        "x" : 1642,
        "y" : 215
      } ]
    } ]
  }, {
    "id" : 363,
    "reactomeId" : 198298,
    "displayName" : "AKT translocates to the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1376,
      "y" : 1029
    },
    "minX" : 1336,
    "maxX" : 1616,
    "minY" : 631,
    "maxY" : 1035,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1616,
        "y" : 631
      },
      "to" : {
        "x" : 1376,
        "y" : 1029
      }
    }, {
      "from" : {
        "x" : 1376,
        "y" : 1029
      },
      "to" : {
        "x" : 1336,
        "y" : 1029
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1343,
        "y" : 1025
      },
      "b" : {
        "x" : 1336,
        "y" : 1029
      },
      "c" : {
        "x" : 1343,
        "y" : 1033
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1343,
        "y" : 1033
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1370,
        "y" : 1023
      },
      "b" : {
        "x" : 1382,
        "y" : 1035
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1376,
        "y" : 1029
      }
    },
    "inputs" : [ {
      "id" : 312
    } ],
    "outputs" : [ {
      "id" : 307
    } ]
  }, {
    "id" : 364,
    "reactomeId" : 198611,
    "displayName" : "AKT phosphorylates IKKalpha",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2145,
      "y" : 725
    },
    "minX" : 2139,
    "maxX" : 2151,
    "minY" : 575,
    "maxY" : 813,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2144,
        "y" : 575
      },
      "to" : {
        "x" : 2145,
        "y" : 725
      }
    }, {
      "from" : {
        "x" : 2145,
        "y" : 725
      },
      "to" : {
        "x" : 2145,
        "y" : 813
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2139,
        "y" : 719
      },
      "b" : {
        "x" : 2151,
        "y" : 731
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2145,
        "y" : 725
      }
    },
    "inputs" : [ {
      "id" : 320,
      "points" : [ {
        "x" : 2032,
        "y" : 539
      } ]
    }, {
      "id" : 336,
      "points" : [ {
        "x" : 2234,
        "y" : 527
      } ]
    } ],
    "outputs" : [ {
      "id" : 332,
      "points" : [ {
        "x" : 2037,
        "y" : 801
      } ]
    }, {
      "id" : 1163,
      "points" : [ {
        "x" : 2247,
        "y" : 852
      } ]
    } ],
    "catalysts" : [ {
      "id" : 312,
      "points" : [ {
        "x" : 1678,
        "y" : 620
      } ]
    } ]
  }, {
    "id" : 365,
    "reactomeId" : 198609,
    "displayName" : "AKT phosphorylates TSC2, inhibiting it",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2182,
      "y" : 703
    },
    "minX" : 2176,
    "maxX" : 2188,
    "minY" : 524,
    "maxY" : 789,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2181,
        "y" : 524
      },
      "to" : {
        "x" : 2182,
        "y" : 703
      }
    }, {
      "from" : {
        "x" : 2182,
        "y" : 703
      },
      "to" : {
        "x" : 2183,
        "y" : 789
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2176,
        "y" : 697
      },
      "b" : {
        "x" : 2188,
        "y" : 709
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2182,
        "y" : 703
      }
    },
    "inputs" : [ {
      "id" : 786,
      "points" : [ {
        "x" : 2236,
        "y" : 478
      } ]
    }, {
      "id" : 320,
      "points" : [ {
        "x" : 2032,
        "y" : 532
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 1084,
      "points" : [ {
        "x" : 2260,
        "y" : 807
      } ]
    }, {
      "id" : 332,
      "points" : [ {
        "x" : 2037,
        "y" : 798
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 312,
      "points" : [ {
        "x" : 1678,
        "y" : 617
      } ]
    } ]
  }, {
    "id" : 366,
    "reactomeId" : 198621,
    "displayName" : "AKT phosphorylates caspase-9",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2125,
      "y" : 750
    },
    "minX" : 2119,
    "maxX" : 2131,
    "minY" : 618,
    "maxY" : 839,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2125,
        "y" : 618
      },
      "to" : {
        "x" : 2125,
        "y" : 750
      }
    }, {
      "from" : {
        "x" : 2125,
        "y" : 750
      },
      "to" : {
        "x" : 2125,
        "y" : 839
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2119,
        "y" : 744
      },
      "b" : {
        "x" : 2131,
        "y" : 756
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2125,
        "y" : 750
      }
    },
    "inputs" : [ {
      "id" : 1962,
      "points" : [ {
        "x" : 2253,
        "y" : 575
      } ]
    }, {
      "id" : 320,
      "points" : [ {
        "x" : 2032,
        "y" : 548
      } ]
    } ],
    "outputs" : [ {
      "id" : 332,
      "points" : [ {
        "x" : 2037,
        "y" : 807
      } ]
    }, {
      "id" : 1242,
      "points" : [ {
        "x" : 2206,
        "y" : 890
      } ]
    } ],
    "catalysts" : [ {
      "id" : 312,
      "points" : [ {
        "x" : 1678,
        "y" : 623
      } ]
    } ]
  }, {
    "id" : 367,
    "reactomeId" : 198371,
    "displayName" : "AKT phosphorylates GSK3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1950,
      "y" : 648
    },
    "minX" : 1944,
    "maxX" : 1956,
    "minY" : 576,
    "maxY" : 852,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1950,
        "y" : 576
      },
      "to" : {
        "x" : 1950,
        "y" : 648
      }
    }, {
      "from" : {
        "x" : 1950,
        "y" : 648
      },
      "to" : {
        "x" : 1948,
        "y" : 852
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1944,
        "y" : 642
      },
      "b" : {
        "x" : 1956,
        "y" : 654
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1950,
        "y" : 648
      }
    },
    "inputs" : [ {
      "id" : 320,
      "points" : [ {
        "x" : 1987,
        "y" : 547
      } ]
    }, {
      "id" : 324,
      "points" : [ {
        "x" : 1799,
        "y" : 541
      } ]
    } ],
    "outputs" : [ {
      "id" : 335,
      "points" : [ {
        "x" : 1869,
        "y" : 953
      } ]
    }, {
      "id" : 332,
      "points" : [ {
        "x" : 1995,
        "y" : 818
      } ]
    } ],
    "catalysts" : [ {
      "id" : 312,
      "points" : [ {
        "x" : 1678,
        "y" : 615
      } ]
    } ]
  }, {
    "id" : 368,
    "reactomeId" : 198613,
    "displayName" : "AKT phosphorylates p21Cip1 and p27Kip1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1870,
      "y" : 566
    },
    "minX" : 1864,
    "maxX" : 1876,
    "minY" : 474,
    "maxY" : 750,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1871,
        "y" : 474
      },
      "to" : {
        "x" : 1870,
        "y" : 566
      }
    }, {
      "from" : {
        "x" : 1870,
        "y" : 566
      },
      "to" : {
        "x" : 1869,
        "y" : 750
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1864,
        "y" : 560
      },
      "b" : {
        "x" : 1876,
        "y" : 572
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1870,
        "y" : 566
      }
    },
    "inputs" : [ {
      "id" : 1698,
      "points" : [ {
        "x" : 1821,
        "y" : 437
      } ]
    }, {
      "id" : 320,
      "points" : [ {
        "x" : 1987,
        "y" : 525
      } ]
    } ],
    "outputs" : [ {
      "id" : 332,
      "points" : [ {
        "x" : 1991,
        "y" : 793
      } ]
    }, {
      "id" : 321,
      "points" : [ {
        "x" : 1746,
        "y" : 766
      } ]
    } ],
    "catalysts" : [ {
      "id" : 312,
      "points" : [ {
        "x" : 1678,
        "y" : 601
      } ]
    } ]
  }, {
    "id" : 369,
    "reactomeId" : 198599,
    "displayName" : "AKT phosphorylates MDM2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2100,
      "y" : 764
    },
    "minX" : 2094,
    "maxX" : 2106,
    "minY" : 646,
    "maxY" : 869,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2100,
        "y" : 646
      },
      "to" : {
        "x" : 2100,
        "y" : 764
      }
    }, {
      "from" : {
        "x" : 2100,
        "y" : 764
      },
      "to" : {
        "x" : 2100,
        "y" : 869
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2094,
        "y" : 758
      },
      "b" : {
        "x" : 2106,
        "y" : 770
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2100,
        "y" : 764
      }
    },
    "inputs" : [ {
      "id" : 330,
      "points" : [ {
        "x" : 2234,
        "y" : 609
      } ]
    }, {
      "id" : 320,
      "points" : [ {
        "x" : 2020,
        "y" : 552
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 323,
      "points" : [ {
        "x" : 2152,
        "y" : 962
      } ]
    }, {
      "id" : 332,
      "points" : [ {
        "x" : 2032,
        "y" : 818
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 312,
      "points" : [ {
        "x" : 1671,
        "y" : 631
      } ]
    } ]
  }, {
    "id" : 497,
    "reactomeId" : 2316434,
    "displayName" : "PI3K phosphorylates PIP2 to PIP3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 360,
      "y" : 406
    },
    "minX" : 354,
    "maxX" : 366,
    "minY" : 371,
    "maxY" : 440,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 360,
        "y" : 440
      },
      "to" : {
        "x" : 360,
        "y" : 406
      }
    }, {
      "from" : {
        "x" : 360,
        "y" : 406
      },
      "to" : {
        "x" : 361,
        "y" : 371
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 354,
        "y" : 400
      },
      "b" : {
        "x" : 366,
        "y" : 412
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 360,
        "y" : 406
      }
    },
    "inputs" : [ {
      "id" : 498,
      "points" : [ {
        "x" : 375,
        "y" : 460
      } ]
    }, {
      "id" : 353,
      "points" : [ {
        "x" : 298,
        "y" : 582
      } ]
    } ],
    "outputs" : [ {
      "id" : 499,
      "points" : [ {
        "x" : 380,
        "y" : 353
      } ]
    }, {
      "id" : 313,
      "points" : [ {
        "x" : 303,
        "y" : 275
      } ]
    } ],
    "catalysts" : [ {
      "id" : 500,
      "points" : [ {
        "x" : 330,
        "y" : 407
      } ]
    } ],
    "activators" : [ {
      "id" : 1869,
      "points" : [ {
        "x" : 472,
        "y" : 567
      }, {
        "x" : 428,
        "y" : 404
      } ]
    } ]
  }, {
    "id" : 370,
    "reactomeId" : 200143,
    "displayName" : "AKT phosphorylates AKT1S1 (PRAS40)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1890,
      "y" : 585
    },
    "minX" : 1884,
    "maxX" : 1896,
    "minY" : 501,
    "maxY" : 788,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1889,
        "y" : 501
      },
      "to" : {
        "x" : 1890,
        "y" : 585
      }
    }, {
      "from" : {
        "x" : 1890,
        "y" : 585
      },
      "to" : {
        "x" : 1890,
        "y" : 788
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1884,
        "y" : 579
      },
      "b" : {
        "x" : 1896,
        "y" : 591
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1890,
        "y" : 585
      }
    },
    "inputs" : [ {
      "id" : 334,
      "points" : [ {
        "x" : 1889,
        "y" : 412
      } ]
    }, {
      "id" : 320,
      "points" : [ {
        "x" : 1987,
        "y" : 528
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 1082,
      "points" : [ {
        "x" : 1768,
        "y" : 813
      } ]
    }, {
      "id" : 332,
      "points" : [ {
        "x" : 1991,
        "y" : 798
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 312,
      "points" : [ {
        "x" : 1678,
        "y" : 605
      } ]
    } ]
  }, {
    "id" : 371,
    "reactomeId" : 198347,
    "displayName" : "AKT phosphorylates BAD",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1932,
      "y" : 624
    },
    "minX" : 1926,
    "maxX" : 1938,
    "minY" : 549,
    "maxY" : 839,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1933,
        "y" : 549
      },
      "to" : {
        "x" : 1932,
        "y" : 624
      }
    }, {
      "from" : {
        "x" : 1932,
        "y" : 624
      },
      "to" : {
        "x" : 1927,
        "y" : 839
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1926,
        "y" : 618
      },
      "b" : {
        "x" : 1938,
        "y" : 630
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1932,
        "y" : 624
      }
    },
    "inputs" : [ {
      "id" : 320,
      "points" : [ {
        "x" : 1987,
        "y" : 537
      } ]
    }, {
      "id" : 326,
      "points" : [ {
        "x" : 1808,
        "y" : 506
      } ]
    } ],
    "outputs" : [ {
      "id" : 332,
      "points" : [ {
        "x" : 1991,
        "y" : 808
      } ]
    }, {
      "id" : 1083,
      "points" : [ {
        "x" : 1776,
        "y" : 926
      } ]
    } ],
    "catalysts" : [ {
      "id" : 312,
      "points" : [ {
        "x" : 1678,
        "y" : 612
      } ]
    } ]
  }, {
    "id" : 372,
    "reactomeId" : 199298,
    "displayName" : "AKT phosphorylates CREB1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1203,
      "y" : 982
    },
    "minX" : 1197,
    "maxX" : 1210,
    "minY" : 878,
    "maxY" : 1092,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1201,
        "y" : 878
      },
      "to" : {
        "x" : 1203,
        "y" : 982
      }
    }, {
      "from" : {
        "x" : 1203,
        "y" : 982
      },
      "to" : {
        "x" : 1210,
        "y" : 1092
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1197,
        "y" : 976
      },
      "b" : {
        "x" : 1209,
        "y" : 988
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1203,
        "y" : 982
      }
    },
    "inputs" : [ {
      "id" : 342,
      "points" : [ {
        "x" : 1062,
        "y" : 885
      } ]
    }, {
      "id" : 343,
      "points" : [ {
        "x" : 1219,
        "y" : 842
      } ]
    } ],
    "outputs" : [ {
      "id" : 339,
      "points" : [ {
        "x" : 1052,
        "y" : 1225
      } ]
    }, {
      "id" : 1001,
      "points" : [ {
        "x" : 1231,
        "y" : 1103
      } ]
    } ],
    "catalysts" : [ {
      "id" : 307,
      "points" : [ {
        "x" : 1261,
        "y" : 1011
      } ]
    } ]
  }, {
    "id" : 373,
    "reactomeId" : 199839,
    "displayName" : "AKT can phosphorylate RSK",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1181,
      "y" : 1005
    },
    "minX" : 1175,
    "maxX" : 1187,
    "minY" : 932,
    "maxY" : 1156,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1181,
        "y" : 932
      },
      "to" : {
        "x" : 1181,
        "y" : 1005
      }
    }, {
      "from" : {
        "x" : 1181,
        "y" : 1005
      },
      "to" : {
        "x" : 1185,
        "y" : 1156
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1175,
        "y" : 999
      },
      "b" : {
        "x" : 1187,
        "y" : 1011
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1181,
        "y" : 1005
      }
    },
    "inputs" : [ {
      "id" : 342,
      "points" : [ {
        "x" : 1062,
        "y" : 895
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 340,
      "points" : [ {
        "x" : 1242,
        "y" : 881
      } ]
    } ],
    "outputs" : [ {
      "id" : 339,
      "points" : [ {
        "x" : 1060,
        "y" : 1225
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 1081,
      "points" : [ {
        "x" : 1220,
        "y" : 1168
      } ]
    } ],
    "catalysts" : [ {
      "id" : 307,
      "points" : [ {
        "x" : 1232,
        "y" : 1018
      } ]
    } ]
  }, {
    "id" : 374,
    "reactomeId" : 199299,
    "displayName" : "AKT phosphorylates FOXO transcription factors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1163,
      "y" : 1027
    },
    "minX" : 1157,
    "maxX" : 1169,
    "minY" : 949,
    "maxY" : 1188,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1161,
        "y" : 949
      },
      "to" : {
        "x" : 1163,
        "y" : 1027
      }
    }, {
      "from" : {
        "x" : 1163,
        "y" : 1027
      },
      "to" : {
        "x" : 1166,
        "y" : 1188
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1157,
        "y" : 1021
      },
      "b" : {
        "x" : 1169,
        "y" : 1033
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1163,
        "y" : 1027
      }
    },
    "inputs" : [ {
      "id" : 342,
      "points" : [ {
        "x" : 1062,
        "y" : 899
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 346,
      "points" : [ {
        "x" : 1232,
        "y" : 930
      } ]
    } ],
    "outputs" : [ {
      "id" : 1882,
      "points" : [ {
        "x" : 1220,
        "y" : 1225
      } ]
    }, {
      "id" : 339,
      "points" : [ {
        "x" : 1066,
        "y" : 1230
      } ],
      "stoichiometry" : 3
    } ],
    "catalysts" : [ {
      "id" : 307,
      "points" : [ {
        "x" : 1232,
        "y" : 1028
      } ]
    } ]
  }, {
    "id" : 1526,
    "reactomeId" : 1676082,
    "displayName" : "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 438,
      "y" : 1282
    },
    "minX" : 432,
    "maxX" : 444,
    "minY" : 1165,
    "maxY" : 1344,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 440,
        "y" : 1344
      },
      "to" : {
        "x" : 438,
        "y" : 1282
      }
    }, {
      "from" : {
        "x" : 438,
        "y" : 1282
      },
      "to" : {
        "x" : 439,
        "y" : 1165
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 432,
        "y" : 1276
      },
      "b" : {
        "x" : 444,
        "y" : 1288
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 438,
        "y" : 1282
      }
    },
    "inputs" : [ {
      "id" : 1533,
      "points" : [ {
        "x" : 389,
        "y" : 1396
      } ]
    }, {
      "id" : 1527,
      "points" : [ {
        "x" : 319,
        "y" : 1394
      } ]
    } ],
    "outputs" : [ {
      "id" : 353,
      "points" : [ {
        "x" : 296,
        "y" : 620
      } ]
    }, {
      "id" : 1534,
      "points" : [ {
        "x" : 511,
        "y" : 1089
      } ]
    } ],
    "catalysts" : [ {
      "id" : 1530,
      "points" : [ {
        "x" : 505,
        "y" : 1282
      } ]
    } ]
  }, {
    "id" : 375,
    "reactomeId" : 199863,
    "displayName" : "AKT can phosphorylate NR4A1 (NUR77)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1144,
      "y" : 1059
    },
    "minX" : 1138,
    "maxX" : 1150,
    "minY" : 969,
    "maxY" : 1241,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1141,
        "y" : 969
      },
      "to" : {
        "x" : 1144,
        "y" : 1059
      }
    }, {
      "from" : {
        "x" : 1144,
        "y" : 1059
      },
      "to" : {
        "x" : 1148,
        "y" : 1241
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1138,
        "y" : 1053
      },
      "b" : {
        "x" : 1150,
        "y" : 1065
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1144,
        "y" : 1059
      }
    },
    "inputs" : [ {
      "id" : 342,
      "points" : [ {
        "x" : 1049,
        "y" : 904
      } ]
    }, {
      "id" : 337,
      "points" : [ {
        "x" : 1243,
        "y" : 965
      } ]
    } ],
    "outputs" : [ {
      "id" : 339,
      "points" : [ {
        "x" : 1066,
        "y" : 1241
      } ]
    }, {
      "id" : 1080,
      "points" : [ {
        "x" : 1169,
        "y" : 1306
      } ]
    } ],
    "catalysts" : [ {
      "id" : 307,
      "points" : [ {
        "x" : 1232,
        "y" : 1039
      } ]
    } ]
  }, {
    "id" : 1975,
    "reactomeId" : 6795290,
    "displayName" : "mTORC2 phosphorylates SGK1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 854,
      "y" : 380
    },
    "minX" : 814,
    "maxX" : 895,
    "minY" : 374,
    "maxY" : 386,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 814,
        "y" : 378
      },
      "to" : {
        "x" : 854,
        "y" : 380
      }
    }, {
      "from" : {
        "x" : 854,
        "y" : 380
      },
      "to" : {
        "x" : 895,
        "y" : 374
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 848,
        "y" : 374
      },
      "b" : {
        "x" : 860,
        "y" : 386
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 854,
        "y" : 380
      }
    },
    "inputs" : [ {
      "id" : 1977,
      "points" : [ {
        "x" : 760,
        "y" : 375
      } ]
    }, {
      "id" : 1998,
      "points" : [ {
        "x" : 791,
        "y" : 402
      } ]
    } ],
    "outputs" : [ {
      "id" : 1978,
      "points" : [ {
        "x" : 931,
        "y" : 413
      } ]
    }, {
      "id" : 1979,
      "points" : [ {
        "x" : 947,
        "y" : 374
      } ]
    } ],
    "catalysts" : [ {
      "id" : 2067,
      "points" : [ {
        "x" : 806,
        "y" : 161
      } ]
    } ]
  }, {
    "id" : 376,
    "reactomeId" : 199443,
    "displayName" : "THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 623,
      "y" : 66
    },
    "minX" : 586,
    "maxX" : 645,
    "minY" : 61,
    "maxY" : 88,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 586,
        "y" : 66
      },
      "to" : {
        "x" : 623,
        "y" : 66
      }
    }, {
      "from" : {
        "x" : 623,
        "y" : 66
      },
      "to" : {
        "x" : 645,
        "y" : 88
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 637,
        "y" : 86
      },
      "b" : {
        "x" : 645,
        "y" : 88
      },
      "c" : {
        "x" : 643,
        "y" : 80
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 643,
        "y" : 80
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 623,
        "y" : 66
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 623,
        "y" : 66
      }
    },
    "inputs" : [ {
      "id" : 574,
      "points" : [ {
        "x" : 492,
        "y" : 99
      } ]
    }, {
      "id" : 784,
      "points" : [ {
        "x" : 575,
        "y" : 87
      } ]
    } ],
    "outputs" : [ {
      "id" : 347
    } ]
  }, {
    "id" : 377,
    "reactomeId" : 199456,
    "displayName" : "PTEN dephosphorylates PIP3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 474,
      "y" : 384
    },
    "minX" : 468,
    "maxX" : 480,
    "minY" : 353,
    "maxY" : 421,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 473,
        "y" : 353
      },
      "to" : {
        "x" : 474,
        "y" : 384
      }
    }, {
      "from" : {
        "x" : 474,
        "y" : 384
      },
      "to" : {
        "x" : 473,
        "y" : 421
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 468,
        "y" : 378
      },
      "b" : {
        "x" : 480,
        "y" : 390
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 474,
        "y" : 384
      }
    },
    "inputs" : [ {
      "id" : 313,
      "points" : [ {
        "x" : 323,
        "y" : 275
      } ]
    }, {
      "id" : 355,
      "points" : [ {
        "x" : 502,
        "y" : 335
      } ]
    } ],
    "outputs" : [ {
      "id" : 353,
      "points" : [ {
        "x" : 308,
        "y" : 582
      } ]
    }, {
      "id" : 357,
      "points" : [ {
        "x" : 486,
        "y" : 433
      } ]
    } ],
    "catalysts" : [ {
      "id" : 1796,
      "points" : [ {
        "x" : 510,
        "y" : 382
      } ]
    } ]
  }, {
    "id" : 378,
    "reactomeId" : 199425,
    "displayName" : "PHLPP dephosphorylates S473 in AKT",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1539,
      "y" : 561
    },
    "minX" : 1495,
    "maxX" : 1583,
    "minY" : 555,
    "maxY" : 567,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1583,
        "y" : 559
      },
      "to" : {
        "x" : 1539,
        "y" : 561
      }
    }, {
      "from" : {
        "x" : 1539,
        "y" : 561
      },
      "to" : {
        "x" : 1495,
        "y" : 563
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1533,
        "y" : 555
      },
      "b" : {
        "x" : 1545,
        "y" : 567
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1539,
        "y" : 561
      }
    },
    "inputs" : [ {
      "id" : 312,
      "points" : [ {
        "x" : 1612,
        "y" : 589
      } ]
    }, {
      "id" : 555,
      "points" : [ {
        "x" : 1591,
        "y" : 535
      } ]
    } ],
    "outputs" : [ {
      "id" : 556,
      "points" : [ {
        "x" : 1479,
        "y" : 589
      } ]
    }, {
      "id" : 359,
      "points" : [ {
        "x" : 1477,
        "y" : 536
      } ]
    } ],
    "catalysts" : [ {
      "id" : 352,
      "points" : [ {
        "x" : 1539,
        "y" : 518
      } ]
    } ]
  }, {
    "id" : 1531,
    "reactomeId" : 1675776,
    "displayName" : "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 487,
      "y" : 1254
    },
    "minX" : 481,
    "maxX" : 493,
    "minY" : 1108,
    "maxY" : 1330,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 488,
        "y" : 1330
      },
      "to" : {
        "x" : 487,
        "y" : 1254
      }
    }, {
      "from" : {
        "x" : 487,
        "y" : 1254
      },
      "to" : {
        "x" : 488,
        "y" : 1108
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 481,
        "y" : 1248
      },
      "b" : {
        "x" : 493,
        "y" : 1260
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 487,
        "y" : 1254
      }
    },
    "inputs" : [ {
      "id" : 1532,
      "points" : [ {
        "x" : 1435,
        "y" : 1441
      }, {
        "x" : 607,
        "y" : 1411
      } ]
    }, {
      "id" : 1533,
      "points" : [ {
        "x" : 394,
        "y" : 1396
      } ]
    } ],
    "outputs" : [ {
      "id" : 353,
      "points" : [ {
        "x" : 298,
        "y" : 620
      } ]
    }, {
      "id" : 1534,
      "points" : [ {
        "x" : 510,
        "y" : 1089
      } ]
    } ],
    "catalysts" : [ {
      "id" : 1535,
      "points" : [ {
        "x" : 547,
        "y" : 1222
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 316,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1377,
      "y" : 777
    },
    "minX" : 286,
    "maxX" : 2469,
    "minY" : 108,
    "maxY" : 1446,
    "prop" : {
      "x" : 286,
      "y" : 108,
      "width" : 2183,
      "height" : 1338
    },
    "textPosition" : {
      "x" : 685,
      "y" : 421
    },
    "insets" : {
      "x" : 304,
      "y" : 139,
      "width" : 2154,
      "height" : 1297
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 360, 362, 313, 318, 312, 320, 321, 323, 324, 326, 330, 332, 334, 335, 336, 364, 365, 366, 367, 368, 369, 370, 371, 377, 355, 357, 353, 378, 359, 352, 392, 420, 421, 432, 433, 434, 443, 471, 478, 486, 487, 488, 489, 497, 498, 499, 500, 534, 536, 537, 535, 540, 541, 545, 551, 548, 555, 556, 574, 576, 582, 774, 778, 775, 777, 781, 347, 784, 786, 788, 792, 841, 1082, 1083, 1084, 1163, 1242, 1243, 1526, 1531, 1533, 1535, 1534, 1532, 1530, 1545, 1546, 1547, 1548, 1549, 1550, 1551, 1553, 1556, 1557, 1558, 1559, 1560, 1561, 1562, 1563, 1564, 1571, 1572, 1692, 1693, 1694, 1695, 1696, 1691, 1698, 1700, 1763, 1765, 1766, 1769, 1770, 1796, 1862, 1863, 1865, 1867, 1868, 1869, 779, 477, 1527, 793, 1879, 1881, 1895, 1896, 1897, 1898, 1962, 1963, 1968, 1970, 1971, 1972, 1974, 1975, 1977, 1978, 1979, 1988, 1989, 1990, 1991, 1998, 2067 ]
  }, {
    "id" : 318,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1144,
      "y" : 1062
    },
    "minX" : 905,
    "maxX" : 1384,
    "minY" : 750,
    "maxY" : 1375,
    "prop" : {
      "x" : 905,
      "y" : 750,
      "width" : 479,
      "height" : 625
    },
    "textPosition" : {
      "x" : 925,
      "y" : 1326
    },
    "insets" : {
      "x" : 922,
      "y" : 761,
      "width" : 450,
      "height" : 601
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 337, 339, 340, 342, 343, 346, 372, 373, 374, 375, 307, 1001, 1080, 1081, 1861, 363, 1882 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 832,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 161,
      "y" : 593
    },
    "minX" : 146,
    "maxX" : 277,
    "minY" : 433,
    "maxY" : 599,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 146,
        "y" : 593
      },
      "to" : {
        "x" : 161,
        "y" : 593
      }
    }, {
      "from" : {
        "x" : 161,
        "y" : 593
      },
      "to" : {
        "x" : 277,
        "y" : 433
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 276,
        "y" : 441
      },
      "b" : {
        "x" : 277,
        "y" : 433
      },
      "c" : {
        "x" : 270,
        "y" : 436
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 270,
        "y" : 436
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 155,
        "y" : 587
      },
      "b" : {
        "x" : 167,
        "y" : 599
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 161,
        "y" : 593
      }
    },
    "inputs" : [ {
      "id" : 823
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  }, {
    "id" : 1862,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 911,
      "y" : 555
    },
    "minX" : 566,
    "maxX" : 1257,
    "minY" : 396,
    "maxY" : 714,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1257,
        "y" : 714
      },
      "to" : {
        "x" : 566,
        "y" : 396
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 574,
        "y" : 395
      },
      "b" : {
        "x" : 566,
        "y" : 396
      },
      "c" : {
        "x" : 571,
        "y" : 403
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 571,
        "y" : 403
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 905,
        "y" : 549
      },
      "b" : {
        "x" : 917,
        "y" : 561
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 911,
        "y" : 555
      }
    },
    "inputs" : [ {
      "id" : 1861
    } ],
    "outputs" : [ {
      "id" : 1796
    } ]
  }, {
    "id" : 1548,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1619,
      "y" : 1127
    },
    "minX" : 1613,
    "maxX" : 1686,
    "minY" : 631,
    "maxY" : 1148,
    "segments" : [ {
      "from" : {
        "x" : 1686,
        "y" : 1148
      },
      "to" : {
        "x" : 1619,
        "y" : 1127
      }
    }, {
      "from" : {
        "x" : 1619,
        "y" : 1127
      },
      "to" : {
        "x" : 1624,
        "y" : 631
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1613,
        "y" : 1121
      },
      "b" : {
        "x" : 1625,
        "y" : 1133
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1619,
        "y" : 1127
      }
    },
    "inputs" : [ {
      "id" : 1547
    } ],
    "outputs" : [ {
      "id" : 312
    } ]
  }, {
    "id" : 1868,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1539,
      "y" : 821
    },
    "minX" : 1391,
    "maxX" : 1688,
    "minY" : 769,
    "maxY" : 873,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1688,
        "y" : 873
      },
      "to" : {
        "x" : 1391,
        "y" : 769
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1399,
        "y" : 768
      },
      "b" : {
        "x" : 1391,
        "y" : 769
      },
      "c" : {
        "x" : 1396,
        "y" : 775
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1396,
        "y" : 775
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1533,
        "y" : 815
      },
      "b" : {
        "x" : 1545,
        "y" : 827
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1539,
        "y" : 821
      }
    },
    "inputs" : [ {
      "id" : 1867
    } ],
    "outputs" : [ {
      "id" : 1861
    } ]
  }, {
    "id" : 1550,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 638,
      "y" : 1151
    },
    "minX" : 524,
    "maxX" : 1778,
    "minY" : 253,
    "maxY" : 1488,
    "segments" : [ {
      "from" : {
        "x" : 1778,
        "y" : 1403
      },
      "to" : {
        "x" : 1745,
        "y" : 1488
      }
    }, {
      "from" : {
        "x" : 1745,
        "y" : 1488
      },
      "to" : {
        "x" : 673,
        "y" : 1484
      }
    }, {
      "from" : {
        "x" : 673,
        "y" : 1484
      },
      "to" : {
        "x" : 603,
        "y" : 819
      }
    }, {
      "from" : {
        "x" : 603,
        "y" : 819
      },
      "to" : {
        "x" : 590,
        "y" : 346
      }
    }, {
      "from" : {
        "x" : 590,
        "y" : 346
      },
      "to" : {
        "x" : 524,
        "y" : 253
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 632,
        "y" : 1145
      },
      "b" : {
        "x" : 644,
        "y" : 1157
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 638,
        "y" : 1151
      }
    },
    "inputs" : [ {
      "id" : 1549
    } ],
    "outputs" : [ {
      "id" : 392
    } ]
  }, {
    "id" : 1744,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 165,
      "y" : 723
    },
    "minX" : 146,
    "maxX" : 282,
    "minY" : 433,
    "maxY" : 729,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 146,
        "y" : 723
      },
      "to" : {
        "x" : 165,
        "y" : 723
      }
    }, {
      "from" : {
        "x" : 165,
        "y" : 723
      },
      "to" : {
        "x" : 282,
        "y" : 433
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 283,
        "y" : 441
      },
      "b" : {
        "x" : 282,
        "y" : 433
      },
      "c" : {
        "x" : 276,
        "y" : 438
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 276,
        "y" : 438
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 159,
        "y" : 717
      },
      "b" : {
        "x" : 171,
        "y" : 729
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 165,
        "y" : 723
      }
    },
    "inputs" : [ {
      "id" : 1743
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  }, {
    "id" : 1872,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 178,
      "y" : 780
    },
    "minX" : 145,
    "maxX" : 284,
    "minY" : 433,
    "maxY" : 786,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 145,
        "y" : 783
      },
      "to" : {
        "x" : 178,
        "y" : 780
      }
    }, {
      "from" : {
        "x" : 178,
        "y" : 780
      },
      "to" : {
        "x" : 284,
        "y" : 433
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 286,
        "y" : 441
      },
      "b" : {
        "x" : 284,
        "y" : 433
      },
      "c" : {
        "x" : 278,
        "y" : 438
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 278,
        "y" : 438
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 172,
        "y" : 774
      },
      "b" : {
        "x" : 184,
        "y" : 786
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 178,
        "y" : 780
      }
    },
    "inputs" : [ {
      "id" : 1870
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  }, {
    "id" : 1881,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1642,
      "y" : 1171
    },
    "minX" : 1598,
    "maxX" : 1686,
    "minY" : 1165,
    "maxY" : 1177,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1686,
        "y" : 1169
      },
      "to" : {
        "x" : 1598,
        "y" : 1173
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1605,
        "y" : 1169
      },
      "b" : {
        "x" : 1598,
        "y" : 1173
      },
      "c" : {
        "x" : 1605,
        "y" : 1177
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1605,
        "y" : 1177
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1636,
        "y" : 1165
      },
      "b" : {
        "x" : 1648,
        "y" : 1177
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1642,
        "y" : 1171
      }
    },
    "inputs" : [ {
      "id" : 1547
    } ],
    "outputs" : [ {
      "id" : 1879
    } ]
  }, {
    "id" : 1243,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1756,
      "y" : 988
    },
    "minX" : 1750,
    "maxX" : 1762,
    "minY" : 955,
    "maxY" : 1021,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1756,
        "y" : 955
      },
      "to" : {
        "x" : 1756,
        "y" : 1021
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1752,
        "y" : 1014
      },
      "b" : {
        "x" : 1756,
        "y" : 1021
      },
      "c" : {
        "x" : 1760,
        "y" : 1014
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1760,
        "y" : 1014
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1750,
        "y" : 982
      },
      "b" : {
        "x" : 1762,
        "y" : 994
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1756,
        "y" : 988
      }
    },
    "inputs" : [ {
      "id" : 1083
    } ],
    "outputs" : [ {
      "id" : 788
    } ]
  }, {
    "id" : 1572,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1993,
      "y" : 1124
    },
    "minX" : 1962,
    "maxX" : 2024,
    "minY" : 1084,
    "maxY" : 1165,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1962,
        "y" : 1084
      },
      "to" : {
        "x" : 2024,
        "y" : 1165
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2017,
        "y" : 1162
      },
      "b" : {
        "x" : 2024,
        "y" : 1165
      },
      "c" : {
        "x" : 2023,
        "y" : 1157
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2023,
        "y" : 1157
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1987,
        "y" : 1118
      },
      "b" : {
        "x" : 1999,
        "y" : 1130
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1993,
        "y" : 1124
      }
    },
    "inputs" : [ {
      "id" : 1571
    } ],
    "outputs" : [ {
      "id" : 1557
    } ]
  }, {
    "id" : 1700,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1804,
      "y" : 370
    },
    "minX" : 1798,
    "maxX" : 1810,
    "minY" : 346,
    "maxY" : 395,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1804,
        "y" : 395
      },
      "to" : {
        "x" : 1805,
        "y" : 346
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1809,
        "y" : 353
      },
      "b" : {
        "x" : 1805,
        "y" : 346
      },
      "c" : {
        "x" : 1801,
        "y" : 353
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1801,
        "y" : 353
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1798,
        "y" : 364
      },
      "b" : {
        "x" : 1810,
        "y" : 376
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1804,
        "y" : 370
      }
    },
    "inputs" : [ {
      "id" : 1698
    } ],
    "outputs" : [ {
      "id" : 841
    } ]
  }, {
    "id" : 1765,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2247,
      "y" : 434
    },
    "minX" : 2241,
    "maxX" : 2253,
    "minY" : 419,
    "maxY" : 450,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2248,
        "y" : 450
      },
      "to" : {
        "x" : 2247,
        "y" : 419
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2251,
        "y" : 426
      },
      "b" : {
        "x" : 2247,
        "y" : 419
      },
      "c" : {
        "x" : 2243,
        "y" : 426
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2243,
        "y" : 426
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2241,
        "y" : 428
      },
      "b" : {
        "x" : 2253,
        "y" : 440
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2247,
        "y" : 434
      }
    },
    "inputs" : [ {
      "id" : 786
    } ],
    "outputs" : [ {
      "id" : 1763
    } ]
  }, {
    "id" : 1766,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2050,
      "y" : 393
    },
    "minX" : 1924,
    "maxX" : 2176,
    "minY" : 387,
    "maxY" : 399,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1924,
        "y" : 393
      },
      "to" : {
        "x" : 2176,
        "y" : 393
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2169,
        "y" : 397
      },
      "b" : {
        "x" : 2176,
        "y" : 393
      },
      "c" : {
        "x" : 2169,
        "y" : 389
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2169,
        "y" : 389
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2044,
        "y" : 387
      },
      "b" : {
        "x" : 2056,
        "y" : 399
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2050,
        "y" : 393
      }
    },
    "inputs" : [ {
      "id" : 334
    } ],
    "outputs" : [ {
      "id" : 1763
    } ]
  }, {
    "id" : 1770,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2253,
      "y" : 975
    },
    "minX" : 2230,
    "maxX" : 2276,
    "minY" : 969,
    "maxY" : 981,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2230,
        "y" : 976
      },
      "to" : {
        "x" : 2276,
        "y" : 975
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2269,
        "y" : 979
      },
      "b" : {
        "x" : 2276,
        "y" : 975
      },
      "c" : {
        "x" : 2269,
        "y" : 971
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2269,
        "y" : 971
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2247,
        "y" : 969
      },
      "b" : {
        "x" : 2259,
        "y" : 981
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2253,
        "y" : 975
      }
    },
    "inputs" : [ {
      "id" : 323
    } ],
    "outputs" : [ {
      "id" : 1769
    } ]
  }, {
    "id" : 1899,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 196,
      "y" : 797
    },
    "minX" : 190,
    "maxX" : 285,
    "minY" : 433,
    "maxY" : 982,
    "segments" : [ {
      "from" : {
        "x" : 265,
        "y" : 982
      },
      "to" : {
        "x" : 196,
        "y" : 797
      }
    }, {
      "from" : {
        "x" : 196,
        "y" : 797
      },
      "to" : {
        "x" : 285,
        "y" : 433
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 190,
        "y" : 791
      },
      "b" : {
        "x" : 202,
        "y" : 803
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 196,
        "y" : 797
      }
    },
    "inputs" : [ {
      "id" : 1898
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  }, {
    "id" : 1970,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1741,
      "y" : 236
    },
    "minX" : 1728,
    "maxX" : 1755,
    "minY" : 230,
    "maxY" : 242,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1755,
        "y" : 236
      },
      "to" : {
        "x" : 1728,
        "y" : 236
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1735,
        "y" : 232
      },
      "b" : {
        "x" : 1728,
        "y" : 236
      },
      "c" : {
        "x" : 1735,
        "y" : 240
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1735,
        "y" : 240
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1735,
        "y" : 230
      },
      "b" : {
        "x" : 1747,
        "y" : 242
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1741,
        "y" : 236
      }
    },
    "inputs" : [ {
      "id" : 1968
    } ],
    "outputs" : [ {
      "id" : 1963
    } ]
  }, {
    "id" : 1718,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 162,
      "y" : 659
    },
    "minX" : 148,
    "maxX" : 280,
    "minY" : 433,
    "maxY" : 665,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 148,
        "y" : 659
      },
      "to" : {
        "x" : 162,
        "y" : 659
      }
    }, {
      "from" : {
        "x" : 162,
        "y" : 659
      },
      "to" : {
        "x" : 280,
        "y" : 433
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 280,
        "y" : 441
      },
      "b" : {
        "x" : 280,
        "y" : 433
      },
      "c" : {
        "x" : 273,
        "y" : 437
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 273,
        "y" : 437
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 156,
        "y" : 653
      },
      "b" : {
        "x" : 168,
        "y" : 665
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 162,
        "y" : 659
      }
    },
    "inputs" : [ {
      "id" : 1717
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  }, {
    "id" : 824,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 176,
      "y" : 116
    },
    "minX" : 154,
    "maxX" : 282,
    "minY" : 110,
    "maxY" : 384,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 154,
        "y" : 116
      },
      "to" : {
        "x" : 176,
        "y" : 116
      }
    }, {
      "from" : {
        "x" : 176,
        "y" : 116
      },
      "to" : {
        "x" : 282,
        "y" : 384
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 276,
        "y" : 379
      },
      "b" : {
        "x" : 282,
        "y" : 384
      },
      "c" : {
        "x" : 283,
        "y" : 376
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 283,
        "y" : 376
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 170,
        "y" : 110
      },
      "b" : {
        "x" : 182,
        "y" : 122
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 176,
        "y" : 116
      }
    },
    "inputs" : [ {
      "id" : 815
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  }, {
    "id" : 825,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 173,
      "y" : 172
    },
    "minX" : 153,
    "maxX" : 280,
    "minY" : 166,
    "maxY" : 384,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 153,
        "y" : 172
      },
      "to" : {
        "x" : 173,
        "y" : 172
      }
    }, {
      "from" : {
        "x" : 173,
        "y" : 172
      },
      "to" : {
        "x" : 280,
        "y" : 384
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 273,
        "y" : 380
      },
      "b" : {
        "x" : 280,
        "y" : 384
      },
      "c" : {
        "x" : 280,
        "y" : 376
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 280,
        "y" : 376
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 167,
        "y" : 166
      },
      "b" : {
        "x" : 179,
        "y" : 178
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 173,
        "y" : 172
      }
    },
    "inputs" : [ {
      "id" : 816
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  }, {
    "id" : 826,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 175,
      "y" : 228
    },
    "minX" : 151,
    "maxX" : 278,
    "minY" : 222,
    "maxY" : 384,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 151,
        "y" : 228
      },
      "to" : {
        "x" : 175,
        "y" : 228
      }
    }, {
      "from" : {
        "x" : 175,
        "y" : 228
      },
      "to" : {
        "x" : 278,
        "y" : 384
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 271,
        "y" : 380
      },
      "b" : {
        "x" : 278,
        "y" : 384
      },
      "c" : {
        "x" : 278,
        "y" : 376
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 278,
        "y" : 376
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 169,
        "y" : 222
      },
      "b" : {
        "x" : 181,
        "y" : 234
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 175,
        "y" : 228
      }
    },
    "inputs" : [ {
      "id" : 817
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  }, {
    "id" : 827,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 167,
      "y" : 292
    },
    "minX" : 146,
    "maxX" : 270,
    "minY" : 286,
    "maxY" : 384,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 146,
        "y" : 290
      },
      "to" : {
        "x" : 167,
        "y" : 292
      }
    }, {
      "from" : {
        "x" : 167,
        "y" : 292
      },
      "to" : {
        "x" : 270,
        "y" : 384
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 262,
        "y" : 382
      },
      "b" : {
        "x" : 270,
        "y" : 384
      },
      "c" : {
        "x" : 267,
        "y" : 376
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 267,
        "y" : 376
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 161,
        "y" : 286
      },
      "b" : {
        "x" : 173,
        "y" : 298
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 167,
        "y" : 292
      }
    },
    "inputs" : [ {
      "id" : 818
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  }, {
    "id" : 828,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 194,
      "y" : 381
    },
    "minX" : 138,
    "maxX" : 251,
    "minY" : 365,
    "maxY" : 398,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 138,
        "y" : 365
      },
      "to" : {
        "x" : 251,
        "y" : 398
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 243,
        "y" : 400
      },
      "b" : {
        "x" : 251,
        "y" : 398
      },
      "c" : {
        "x" : 245,
        "y" : 392
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 245,
        "y" : 392
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 188,
        "y" : 375
      },
      "b" : {
        "x" : 200,
        "y" : 387
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 194,
        "y" : 381
      }
    },
    "inputs" : [ {
      "id" : 819
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  }, {
    "id" : 829,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 197,
      "y" : 401
    },
    "minX" : 144,
    "maxX" : 251,
    "minY" : 395,
    "maxY" : 407,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 144,
        "y" : 398
      },
      "to" : {
        "x" : 251,
        "y" : 405
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 244,
        "y" : 409
      },
      "b" : {
        "x" : 251,
        "y" : 405
      },
      "c" : {
        "x" : 244,
        "y" : 401
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 244,
        "y" : 401
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 191,
        "y" : 395
      },
      "b" : {
        "x" : 203,
        "y" : 407
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 197,
        "y" : 401
      }
    },
    "inputs" : [ {
      "id" : 822
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  }, {
    "id" : 830,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 198,
      "y" : 427
    },
    "minX" : 145,
    "maxX" : 251,
    "minY" : 415,
    "maxY" : 440,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 145,
        "y" : 440
      },
      "to" : {
        "x" : 251,
        "y" : 415
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 245,
        "y" : 420
      },
      "b" : {
        "x" : 251,
        "y" : 415
      },
      "c" : {
        "x" : 243,
        "y" : 413
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 243,
        "y" : 413
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 192,
        "y" : 421
      },
      "b" : {
        "x" : 204,
        "y" : 433
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 198,
        "y" : 427
      }
    },
    "inputs" : [ {
      "id" : 820
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  }, {
    "id" : 831,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 157,
      "y" : 523
    },
    "minX" : 144,
    "maxX" : 268,
    "minY" : 433,
    "maxY" : 529,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 144,
        "y" : 523
      },
      "to" : {
        "x" : 157,
        "y" : 523
      }
    }, {
      "from" : {
        "x" : 157,
        "y" : 523
      },
      "to" : {
        "x" : 268,
        "y" : 433
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 265,
        "y" : 440
      },
      "b" : {
        "x" : 268,
        "y" : 433
      },
      "c" : {
        "x" : 260,
        "y" : 434
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 260,
        "y" : 434
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 151,
        "y" : 517
      },
      "b" : {
        "x" : 163,
        "y" : 529
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 157,
        "y" : 523
      }
    },
    "inputs" : [ {
      "id" : 821
    } ],
    "outputs" : [ {
      "id" : 500
    } ]
  } ],
  "shadows" : [ {
    "id" : 2068,
    "reactomeId" : 198323,
    "displayName" : "AKT phosphorylates targets in the cytosol",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1983,
      "y" : 686
    },
    "minX" : 1569,
    "maxX" : 2397,
    "minY" : 370,
    "maxY" : 1002,
    "prop" : {
      "x" : 2257,
      "y" : 370,
      "width" : 140,
      "height" : 632
    },
    "points" : [ {
      "x" : 1569,
      "y" : 370
    }, {
      "x" : 2397,
      "y" : 370
    }, {
      "x" : 2397,
      "y" : 1002
    }, {
      "x" : 1569,
      "y" : 1002
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 2069,
    "reactomeId" : 198693,
    "displayName" : "AKT phosphorylates targets in the nucleus",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1184,
      "y" : 1079
    },
    "minX" : 996,
    "maxX" : 1372,
    "minY" : 802,
    "maxY" : 1357,
    "prop" : {
      "x" : 996,
      "y" : 802,
      "width" : 376,
      "height" : 555
    },
    "points" : [ {
      "x" : 996,
      "y" : 802
    }, {
      "x" : 1372,
      "y" : 802
    }, {
      "x" : 1372,
      "y" : 1357
    }, {
      "x" : 996,
      "y" : 1357
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 2070,
    "reactomeId" : 199418,
    "displayName" : "Negative regulation of the PI3K/AKT network",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1252,
      "y" : 764
    },
    "minX" : 247,
    "maxX" : 2257,
    "minY" : 51,
    "maxY" : 1477,
    "prop" : {
      "x" : 247,
      "y" : 51,
      "width" : 749,
      "height" : 1306
    },
    "points" : [ {
      "x" : 247,
      "y" : 51
    }, {
      "x" : 2257,
      "y" : 51
    }, {
      "x" : 2257,
      "y" : 1477
    }, {
      "x" : 247,
      "y" : 1477
    } ],
    "colour" : "#008000"
  } ],
  "minX" : 0,
  "maxX" : 2469,
  "minY" : 0,
  "maxY" : 1488,
  "disease" : true
}