{
  "dbId" : 10827855,
  "stableId" : "R-GGA-112409",
  "displayName" : "RAF-independent MAPK1/3 activation",
  "nodes" : [ {
    "id" : 112481,
    "reactomeId" : 451504,
    "displayName" : "phospho ERK2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1090,
      "y" : 520
    },
    "minX" : 1036,
    "maxX" : 1205,
    "minY" : 492,
    "maxY" : 566,
    "prop" : {
      "x" : 1036,
      "y" : 495,
      "width" : 109,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1039,
      "y" : 502
    },
    "connectors" : [ {
      "edgeId" : 112480,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 112483,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1151,
          "y" : 541
        },
        "to" : {
          "x" : 1205,
          "y" : 566
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 112486,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1151,
          "y" : 506
        },
        "to" : {
          "x" : 1204,
          "y" : 492
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 112482,
    "reactomeId" : 451513,
    "displayName" : "phospho ERK2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1090,
      "y" : 313
    },
    "minX" : 1036,
    "maxX" : 1146,
    "minY" : 272,
    "maxY" : 338,
    "prop" : {
      "x" : 1036,
      "y" : 288,
      "width" : 109,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1039,
      "y" : 295
    },
    "connectors" : [ {
      "edgeId" : 112480,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 112491,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1124,
          "y" : 282
        },
        "to" : {
          "x" : 1146,
          "y" : 272
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 112485,
    "reactomeId" : 10793771,
    "displayName" : "p-T,Y MAPK monomers and dimers:PEA15",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1315,
      "y" : 603
    },
    "minX" : 1260,
    "maxX" : 1377,
    "minY" : 572,
    "maxY" : 628,
    "prop" : {
      "x" : 1260,
      "y" : 578,
      "width" : 111,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1262,
      "y" : 579
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1371,
          "y" : 578
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1371,
          "y" : 578
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112483,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 112484,
    "reactomeId" : 10793769,
    "displayName" : "LOC107049501",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1178,
      "y" : 593
    },
    "minX" : 1154,
    "maxX" : 1209,
    "minY" : 566,
    "maxY" : 604,
    "prop" : {
      "x" : 1154,
      "y" : 582,
      "width" : 49,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1154,
      "y" : 569
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1203,
          "y" : 582
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1203,
          "y" : 582
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112483,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1189,
          "y" : 579
        },
        "to" : {
          "x" : 1205,
          "y" : 566
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 112487,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1179,
      "y" : 455
    },
    "minX" : 1159,
    "maxX" : 1204,
    "minY" : 439,
    "maxY" : 492,
    "prop" : {
      "x" : 1159,
      "y" : 440,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1162,
      "y" : 444
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1195,
          "y" : 445
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1195,
          "y" : 445
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112486,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1189,
          "y" : 473
        },
        "to" : {
          "x" : 1204,
          "y" : 492
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 112489,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1305,
      "y" : 480
    },
    "minX" : 1253,
    "maxX" : 1321,
    "minY" : 464,
    "maxY" : 495,
    "prop" : {
      "x" : 1291,
      "y" : 465,
      "width" : 29,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1296,
      "y" : 469
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1315,
          "y" : 470
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1315,
          "y" : 470
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112486,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1288,
          "y" : 483
        },
        "to" : {
          "x" : 1253,
          "y" : 492
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1282,
          "y" : 489
        },
        "b" : {
          "x" : 1288,
          "y" : 483
        },
        "c" : {
          "x" : 1280,
          "y" : 481
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1280,
          "y" : 481
        }
      }
    } ]
  }, {
    "id" : 112488,
    "reactomeId" : 10793825,
    "displayName" : "MAPK monomers and dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1351,
      "y" : 531
    },
    "minX" : 1253,
    "maxX" : 1413,
    "minY" : 492,
    "maxY" : 549,
    "prop" : {
      "x" : 1290,
      "y" : 513,
      "width" : 123,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1294,
      "y" : 513
    },
    "connectors" : [ {
      "edgeId" : 112486,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1305,
          "y" : 507
        },
        "to" : {
          "x" : 1253,
          "y" : 492
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1297,
          "y" : 509
        },
        "b" : {
          "x" : 1305,
          "y" : 507
        },
        "c" : {
          "x" : 1299,
          "y" : 501
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1299,
          "y" : 501
        }
      }
    } ]
  }, {
    "id" : 112490,
    "reactomeId" : 10793837,
    "displayName" : "cytosolic MAPK DUSPs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1259,
      "y" : 439
    },
    "minX" : 1208,
    "maxX" : 1311,
    "minY" : 421,
    "maxY" : 487,
    "prop" : {
      "x" : 1208,
      "y" : 421,
      "width" : 103,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1208,
      "y" : 421
    },
    "connectors" : [ {
      "edgeId" : 112486,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1248,
          "y" : 463
        },
        "to" : {
          "x" : 1237,
          "y" : 480
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1235,
          "y" : 483
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1235,
          "y" : 483
        }
      }
    } ]
  }, {
    "id" : 112493,
    "reactomeId" : 10793796,
    "displayName" : "MAPK monomers and dimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1266,
      "y" : 319
    },
    "minX" : 1205,
    "maxX" : 1328,
    "minY" : 272,
    "maxY" : 337,
    "prop" : {
      "x" : 1205,
      "y" : 301,
      "width" : 123,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1209,
      "y" : 301
    },
    "connectors" : [ {
      "edgeId" : 112491,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1244,
          "y" : 295
        },
        "to" : {
          "x" : 1209,
          "y" : 272
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1236,
          "y" : 295
        },
        "b" : {
          "x" : 1244,
          "y" : 295
        },
        "c" : {
          "x" : 1240,
          "y" : 288
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1240,
          "y" : 288
        }
      }
    } ]
  }, {
    "id" : 112492,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1107,
      "y" : 236
    },
    "minX" : 1087,
    "maxX" : 1146,
    "minY" : 220,
    "maxY" : 272,
    "prop" : {
      "x" : 1087,
      "y" : 221,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1090,
      "y" : 225
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1123,
          "y" : 226
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1123,
          "y" : 226
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112491,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1123,
          "y" : 254
        },
        "to" : {
          "x" : 1146,
          "y" : 272
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 112495,
    "reactomeId" : 10793818,
    "displayName" : "nuclear MAPK DUSPs",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1176,
      "y" : 184
    },
    "minX" : 1130,
    "maxX" : 1223,
    "minY" : 166,
    "maxY" : 264,
    "prop" : {
      "x" : 1130,
      "y" : 166,
      "width" : 93,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1129,
      "y" : 166
    },
    "connectors" : [ {
      "edgeId" : 112491,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1176,
          "y" : 208
        },
        "to" : {
          "x" : 1178,
          "y" : 256
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1178,
          "y" : 260
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1178,
          "y" : 260
        }
      }
    } ]
  }, {
    "id" : 112494,
    "reactomeId" : 113550,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1240,
      "y" : 232
    },
    "minX" : 1209,
    "maxX" : 1256,
    "minY" : 216,
    "maxY" : 272,
    "prop" : {
      "x" : 1226,
      "y" : 217,
      "width" : 29,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1231,
      "y" : 221
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1250,
          "y" : 222
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1250,
          "y" : 222
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112491,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1228,
          "y" : 250
        },
        "to" : {
          "x" : 1209,
          "y" : 272
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1226,
          "y" : 258
        },
        "b" : {
          "x" : 1228,
          "y" : 250
        },
        "c" : {
          "x" : 1220,
          "y" : 253
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1220,
          "y" : 253
        }
      }
    } ]
  }, {
    "id" : 112469,
    "reactomeId" : 451487,
    "displayName" : "phospho MEK2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 311,
      "y" : 708
    },
    "minX" : 287,
    "maxX" : 387,
    "minY" : 691,
    "maxY" : 739,
    "prop" : {
      "x" : 287,
      "y" : 697,
      "width" : 49,
      "height" : 22
    },
    "textPosition" : {
      "x" : 288,
      "y" : 684
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 336,
          "y" : 697
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 336,
          "y" : 697
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112467,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 339,
          "y" : 717
        },
        "to" : {
          "x" : 387,
          "y" : 739
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 112468,
    "reactomeId" : 433942,
    "displayName" : "ERK2(MAPK1)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 318,
      "y" : 781
    },
    "minX" : 268,
    "maxX" : 1000,
    "minY" : 739,
    "maxY" : 856,
    "prop" : {
      "x" : 268,
      "y" : 770,
      "width" : 100,
      "height" : 22
    },
    "textPosition" : {
      "x" : 273,
      "y" : 770
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 368,
          "y" : 770
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 368,
          "y" : 770
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112467,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 336,
          "y" : 767
        },
        "to" : {
          "x" : 387,
          "y" : 739
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 112475,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 317,
          "y" : 795
        },
        "to" : {
          "x" : 317,
          "y" : 855
        }
      }, {
        "from" : {
          "x" : 317,
          "y" : 855
        },
        "to" : {
          "x" : 1000,
          "y" : 856
        }
      }, {
        "from" : {
          "x" : 1000,
          "y" : 856
        },
        "to" : {
          "x" : 938,
          "y" : 800
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 321,
          "y" : 802
        },
        "b" : {
          "x" : 317,
          "y" : 795
        },
        "c" : {
          "x" : 313,
          "y" : 802
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 313,
          "y" : 802
        }
      }
    } ]
  }, {
    "id" : 112470,
    "reactomeId" : 451495,
    "displayName" : "phospho MEK2 : ERK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 542,
      "y" : 739
    },
    "minX" : 491,
    "maxX" : 671,
    "minY" : 715,
    "maxY" : 757,
    "prop" : {
      "x" : 491,
      "y" : 721,
      "width" : 102,
      "height" : 36
    },
    "textPosition" : {
      "x" : 490,
      "y" : 722
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 593,
          "y" : 721
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 593,
          "y" : 721
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112467,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 112471,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 596,
          "y" : 747
        },
        "to" : {
          "x" : 641,
          "y" : 755
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 112471,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 596,
          "y" : 738
        },
        "to" : {
          "x" : 662,
          "y" : 738
        }
      }, {
        "from" : {
          "x" : 662,
          "y" : 738
        },
        "to" : {
          "x" : 665,
          "y" : 742
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 667,
          "y" : 745
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 667,
          "y" : 745
        }
      }
    } ]
  }, {
    "id" : 112473,
    "reactomeId" : 451480,
    "displayName" : "phospho ERK2 : phospho MEK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 799,
      "y" : 799
    },
    "minX" : 709,
    "maxX" : 870,
    "minY" : 756,
    "maxY" : 817,
    "prop" : {
      "x" : 735,
      "y" : 781,
      "width" : 129,
      "height" : 36
    },
    "textPosition" : {
      "x" : 744,
      "y" : 782
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 864,
          "y" : 781
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 864,
          "y" : 781
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112471,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 761,
          "y" : 778
        },
        "to" : {
          "x" : 709,
          "y" : 756
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 753,
          "y" : 779
        },
        "b" : {
          "x" : 761,
          "y" : 778
        },
        "c" : {
          "x" : 756,
          "y" : 772
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 756,
          "y" : 772
        }
      }
    }, {
      "edgeId" : 112475,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 112472,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 582,
      "y" : 792
    },
    "minX" : 563,
    "maxX" : 641,
    "minY" : 755,
    "maxY" : 807,
    "prop" : {
      "x" : 563,
      "y" : 777,
      "width" : 38,
      "height" : 30
    },
    "textPosition" : {
      "x" : 566,
      "y" : 781
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 596,
          "y" : 782
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 596,
          "y" : 782
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112471,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 604,
          "y" : 780
        },
        "to" : {
          "x" : 641,
          "y" : 755
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 616,
            "y" : 761
          },
          "b" : {
            "x" : 628,
            "y" : 773
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 622,
            "y" : 767
          }
        }
      }
    } ]
  }, {
    "id" : 112474,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 763,
      "y" : 722
    },
    "minX" : 709,
    "maxX" : 784,
    "minY" : 706,
    "maxY" : 756,
    "prop" : {
      "x" : 743,
      "y" : 707,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 746,
      "y" : 711
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 778,
          "y" : 712
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 778,
          "y" : 712
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112471,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 740,
          "y" : 734
        },
        "to" : {
          "x" : 709,
          "y" : 756
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 718,
            "y" : 739
          },
          "b" : {
            "x" : 730,
            "y" : 751
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 724,
            "y" : 745
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 737,
          "y" : 741
        },
        "b" : {
          "x" : 740,
          "y" : 734
        },
        "c" : {
          "x" : 732,
          "y" : 735
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 732,
          "y" : 735
        }
      }
    } ]
  }, {
    "id" : 112476,
    "reactomeId" : 451523,
    "displayName" : "phospho-ERK2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1006,
      "y" : 730
    },
    "minX" : 938,
    "maxX" : 1075,
    "minY" : 706,
    "maxY" : 800,
    "prop" : {
      "x" : 944,
      "y" : 712,
      "width" : 125,
      "height" : 36
    },
    "textPosition" : {
      "x" : 957,
      "y" : 719
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1069,
          "y" : 712
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1069,
          "y" : 712
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112475,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 988,
          "y" : 751
        },
        "to" : {
          "x" : 938,
          "y" : 800
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 986,
          "y" : 759
        },
        "b" : {
          "x" : 988,
          "y" : 751
        },
        "c" : {
          "x" : 980,
          "y" : 753
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 980,
          "y" : 753
        }
      }
    } ]
  }, {
    "id" : 112479,
    "reactomeId" : 10743049,
    "displayName" : "p-T185,Y187 MAPK1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1230,
      "y" : 668
    },
    "minX" : 1166,
    "maxX" : 1301,
    "minY" : 651,
    "maxY" : 679,
    "prop" : {
      "x" : 1166,
      "y" : 657,
      "width" : 129,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1185,
      "y" : 651
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1295,
          "y" : 657
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1295,
          "y" : 657
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112477,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 112478,
    "reactomeId" : 10738596,
    "displayName" : "phospho-MAPK3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1001,
      "y" : 668
    },
    "minX" : 957,
    "maxX" : 1090,
    "minY" : 651,
    "maxY" : 679,
    "prop" : {
      "x" : 957,
      "y" : 657,
      "width" : 89,
      "height" : 22
    },
    "textPosition" : {
      "x" : 968,
      "y" : 651
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1046,
          "y" : 657
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1046,
          "y" : 657
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 112477,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1078,
            "y" : 661
          },
          "b" : {
            "x" : 1090,
            "y" : 673
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1084,
            "y" : 667
          }
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 112480,
    "reactomeId" : 451508,
    "displayName" : "Nuclear translocation of phospho ERK2 dimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1089,
      "y" : 411
    },
    "minX" : 1083,
    "maxX" : 1095,
    "minY" : 344,
    "maxY" : 489,
    "segments" : [ {
      "from" : {
        "x" : 1089,
        "y" : 489
      },
      "to" : {
        "x" : 1089,
        "y" : 411
      }
    }, {
      "from" : {
        "x" : 1089,
        "y" : 411
      },
      "to" : {
        "x" : 1089,
        "y" : 344
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1093,
        "y" : 351
      },
      "b" : {
        "x" : 1089,
        "y" : 344
      },
      "c" : {
        "x" : 1085,
        "y" : 351
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1085,
        "y" : 351
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1083,
        "y" : 405
      },
      "b" : {
        "x" : 1095,
        "y" : 417
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1089,
        "y" : 411
      }
    },
    "inputs" : [ {
      "id" : 112481
    } ],
    "outputs" : [ {
      "id" : 112482
    } ]
  }, {
    "id" : 112483,
    "reactomeId" : 10793794,
    "displayName" : "PEA15 binds MAPK monomers and dimers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1231,
      "y" : 566
    },
    "minX" : 1205,
    "maxX" : 1257,
    "minY" : 560,
    "maxY" : 578,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1205,
        "y" : 566
      },
      "to" : {
        "x" : 1231,
        "y" : 566
      }
    }, {
      "from" : {
        "x" : 1231,
        "y" : 566
      },
      "to" : {
        "x" : 1257,
        "y" : 578
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1249,
        "y" : 579
      },
      "b" : {
        "x" : 1257,
        "y" : 578
      },
      "c" : {
        "x" : 1252,
        "y" : 571
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1252,
        "y" : 571
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1231,
        "y" : 566
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1231,
        "y" : 566
      }
    },
    "inputs" : [ {
      "id" : 112481,
      "points" : [ {
        "x" : 1151,
        "y" : 541
      } ]
    }, {
      "id" : 112484,
      "points" : [ {
        "x" : 1189,
        "y" : 579
      } ]
    } ],
    "outputs" : [ {
      "id" : 112485
    } ]
  }, {
    "id" : 112467,
    "reactomeId" : 451482,
    "displayName" : "activated MEK2 binds ERK2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 438,
      "y" : 739
    },
    "minX" : 387,
    "maxX" : 488,
    "minY" : 733,
    "maxY" : 745,
    "segments" : [ {
      "from" : {
        "x" : 387,
        "y" : 739
      },
      "to" : {
        "x" : 438,
        "y" : 739
      }
    }, {
      "from" : {
        "x" : 438,
        "y" : 739
      },
      "to" : {
        "x" : 488,
        "y" : 739
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 481,
        "y" : 743
      },
      "b" : {
        "x" : 488,
        "y" : 739
      },
      "c" : {
        "x" : 481,
        "y" : 735
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 481,
        "y" : 735
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 432,
        "y" : 733
      },
      "b" : {
        "x" : 444,
        "y" : 745
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 438,
        "y" : 739
      }
    },
    "inputs" : [ {
      "id" : 112468,
      "points" : [ {
        "x" : 336,
        "y" : 767
      } ]
    }, {
      "id" : 112469,
      "points" : [ {
        "x" : 339,
        "y" : 717
      } ]
    } ],
    "outputs" : [ {
      "id" : 112470
    } ]
  }, {
    "id" : 112471,
    "reactomeId" : 451516,
    "displayName" : "activated MEK2 phosphorylates ERK2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 674,
      "y" : 755
    },
    "minX" : 641,
    "maxX" : 709,
    "minY" : 749,
    "maxY" : 761,
    "segments" : [ {
      "from" : {
        "x" : 641,
        "y" : 755
      },
      "to" : {
        "x" : 674,
        "y" : 755
      }
    }, {
      "from" : {
        "x" : 674,
        "y" : 755
      },
      "to" : {
        "x" : 709,
        "y" : 756
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 668,
        "y" : 749
      },
      "b" : {
        "x" : 680,
        "y" : 761
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 674,
        "y" : 755
      }
    },
    "inputs" : [ {
      "id" : 112470,
      "points" : [ {
        "x" : 596,
        "y" : 747
      } ]
    }, {
      "id" : 112472,
      "points" : [ {
        "x" : 604,
        "y" : 780
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 112473,
      "points" : [ {
        "x" : 761,
        "y" : 778
      } ]
    }, {
      "id" : 112474,
      "points" : [ {
        "x" : 740,
        "y" : 734
      } ],
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 112470,
      "points" : [ {
        "x" : 596,
        "y" : 738
      }, {
        "x" : 662,
        "y" : 738
      } ]
    } ]
  }, {
    "id" : 112486,
    "reactomeId" : 10793840,
    "displayName" : "Cytosolic DUSPs dephosphorylate MAPKs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1228,
      "y" : 493
    },
    "minX" : 1204,
    "maxX" : 1253,
    "minY" : 487,
    "maxY" : 499,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1204,
        "y" : 492
      },
      "to" : {
        "x" : 1228,
        "y" : 493
      }
    }, {
      "from" : {
        "x" : 1228,
        "y" : 493
      },
      "to" : {
        "x" : 1253,
        "y" : 492
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1222,
        "y" : 487
      },
      "b" : {
        "x" : 1234,
        "y" : 499
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1228,
        "y" : 493
      }
    },
    "inputs" : [ {
      "id" : 112481,
      "points" : [ {
        "x" : 1151,
        "y" : 506
      } ]
    }, {
      "id" : 112487,
      "points" : [ {
        "x" : 1189,
        "y" : 473
      } ]
    } ],
    "outputs" : [ {
      "id" : 112488,
      "points" : [ {
        "x" : 1305,
        "y" : 507
      } ]
    }, {
      "id" : 112489,
      "points" : [ {
        "x" : 1288,
        "y" : 483
      } ]
    } ],
    "catalysts" : [ {
      "id" : 112490,
      "points" : [ {
        "x" : 1248,
        "y" : 463
      } ]
    } ]
  }, {
    "id" : 112475,
    "reactomeId" : 451505,
    "displayName" : "Dissociation of phospho ERK2 :phospho MEK2 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 901,
      "y" : 800
    },
    "minX" : 867,
    "maxX" : 938,
    "minY" : 794,
    "maxY" : 806,
    "segments" : [ {
      "from" : {
        "x" : 867,
        "y" : 799
      },
      "to" : {
        "x" : 901,
        "y" : 800
      }
    }, {
      "from" : {
        "x" : 901,
        "y" : 800
      },
      "to" : {
        "x" : 938,
        "y" : 800
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 895,
        "y" : 794
      },
      "b" : {
        "x" : 907,
        "y" : 806
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 901,
        "y" : 800
      }
    },
    "inputs" : [ {
      "id" : 112473
    } ],
    "outputs" : [ {
      "id" : 112468,
      "points" : [ {
        "x" : 317,
        "y" : 795
      }, {
        "x" : 317,
        "y" : 855
      }, {
        "x" : 1000,
        "y" : 856
      } ]
    }, {
      "id" : 112476,
      "points" : [ {
        "x" : 988,
        "y" : 751
      } ]
    } ]
  }, {
    "id" : 112491,
    "reactomeId" : 10793821,
    "displayName" : "Nuclear DUSPs dephosphorylate MAPKs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1178,
      "y" : 272
    },
    "minX" : 1146,
    "maxX" : 1209,
    "minY" : 266,
    "maxY" : 278,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1146,
        "y" : 272
      },
      "to" : {
        "x" : 1178,
        "y" : 272
      }
    }, {
      "from" : {
        "x" : 1178,
        "y" : 272
      },
      "to" : {
        "x" : 1209,
        "y" : 272
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1172,
        "y" : 266
      },
      "b" : {
        "x" : 1184,
        "y" : 278
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1178,
        "y" : 272
      }
    },
    "inputs" : [ {
      "id" : 112482,
      "points" : [ {
        "x" : 1124,
        "y" : 282
      } ]
    }, {
      "id" : 112492,
      "points" : [ {
        "x" : 1123,
        "y" : 254
      } ]
    } ],
    "outputs" : [ {
      "id" : 112493,
      "points" : [ {
        "x" : 1244,
        "y" : 295
      } ]
    }, {
      "id" : 112494,
      "points" : [ {
        "x" : 1228,
        "y" : 250
      } ]
    } ],
    "catalysts" : [ {
      "id" : 112495,
      "points" : [ {
        "x" : 1176,
        "y" : 208
      } ]
    } ]
  }, {
    "id" : 112477,
    "reactomeId" : 10793761,
    "displayName" : "p-T,Y MAPKs dimerize",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1116,
      "y" : 667
    },
    "minX" : 1052,
    "maxX" : 1160,
    "minY" : 661,
    "maxY" : 673,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1052,
        "y" : 667
      },
      "to" : {
        "x" : 1116,
        "y" : 667
      }
    }, {
      "from" : {
        "x" : 1116,
        "y" : 667
      },
      "to" : {
        "x" : 1160,
        "y" : 667
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1153,
        "y" : 671
      },
      "b" : {
        "x" : 1160,
        "y" : 667
      },
      "c" : {
        "x" : 1153,
        "y" : 663
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1153,
        "y" : 663
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1116,
        "y" : 667
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1116,
        "y" : 667
      }
    },
    "inputs" : [ {
      "id" : 112478,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 112479
    } ]
  } ],
  "compartments" : [ {
    "id" : 112496,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 718,
      "y" : 457
    },
    "minX" : 0,
    "maxX" : 1437,
    "minY" : 0,
    "maxY" : 914,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1437,
      "height" : 914
    },
    "textPosition" : {
      "x" : 591,
      "y" : 251
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1417,
      "height" : 894
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 112504, 112467, 112468, 112469, 112470, 112471, 112472, 112473, 112474, 112475, 112503, 112476, 112477, 112478, 112479, 112481, 112484, 112483, 112485, 112486, 112487, 112488, 112489, 112490 ]
  }, {
    "id" : 112503,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1180,
      "y" : 225
    },
    "minX" : 1010,
    "maxX" : 1351,
    "minY" : 34,
    "maxY" : 417,
    "prop" : {
      "x" : 1010,
      "y" : 34,
      "width" : 341,
      "height" : 383
    },
    "textPosition" : {
      "x" : 1141,
      "y" : 67
    },
    "insets" : {
      "x" : 1020,
      "y" : 44,
      "width" : 321,
      "height" : 363
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 112482, 112480, 112491, 112492, 112493, 112494, 112495 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1437,
  "minY" : 0,
  "maxY" : 914,
  "disease" : false
}