{
  "dbId" : 10650568,
  "stableId" : "R-DRE-9686114",
  "displayName" : "Non-canonical inflammasome activation",
  "nodes" : [ {
    "id" : 80321,
    "reactomeId" : 10586861,
    "displayName" : "il1fma",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 458,
      "y" : 62
    },
    "minX" : 418,
    "maxX" : 505,
    "minY" : 45,
    "maxY" : 74,
    "prop" : {
      "x" : 418,
      "y" : 51,
      "width" : 81,
      "height" : 23
    },
    "textPosition" : {
      "x" : 436,
      "y" : 52
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 499,
          "y" : 51
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 499,
          "y" : 51
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80320,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80334,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80323,
    "reactomeId" : 10586873,
    "displayName" : "il1fma",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 702,
      "y" : 119
    },
    "minX" : 606,
    "maxX" : 745,
    "minY" : 61,
    "maxY" : 131,
    "prop" : {
      "x" : 666,
      "y" : 108,
      "width" : 73,
      "height" : 23
    },
    "textPosition" : {
      "x" : 680,
      "y" : 109
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 739,
          "y" : 108
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 739,
          "y" : 108
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80320,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 663,
          "y" : 108
        },
        "to" : {
          "x" : 606,
          "y" : 92
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 655,
          "y" : 110
        },
        "b" : {
          "x" : 663,
          "y" : 108
        },
        "c" : {
          "x" : 657,
          "y" : 102
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 657,
          "y" : 102
        }
      }
    }, {
      "edgeId" : 80334,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 684,
          "y" : 105
        },
        "to" : {
          "x" : 614,
          "y" : 61
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 676,
          "y" : 105
        },
        "b" : {
          "x" : 684,
          "y" : 105
        },
        "c" : {
          "x" : 680,
          "y" : 98
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 680,
          "y" : 98
        }
      }
    } ]
  }, {
    "id" : 80322,
    "reactomeId" : 10586867,
    "displayName" : "il1fma",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 732,
      "y" : 64
    },
    "minX" : 606,
    "maxX" : 783,
    "minY" : 47,
    "maxY" : 92,
    "prop" : {
      "x" : 688,
      "y" : 53,
      "width" : 89,
      "height" : 23
    },
    "textPosition" : {
      "x" : 710,
      "y" : 54
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 777,
          "y" : 53
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 777,
          "y" : 53
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80320,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 685,
          "y" : 73
        },
        "to" : {
          "x" : 606,
          "y" : 92
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 679,
          "y" : 79
        },
        "b" : {
          "x" : 685,
          "y" : 73
        },
        "c" : {
          "x" : 677,
          "y" : 71
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 677,
          "y" : 71
        }
      }
    }, {
      "edgeId" : 80334,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 685,
          "y" : 62
        },
        "to" : {
          "x" : 614,
          "y" : 61
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 678,
          "y" : 66
        },
        "b" : {
          "x" : 685,
          "y" : 62
        },
        "c" : {
          "x" : 678,
          "y" : 58
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 678,
          "y" : 58
        }
      }
    } ]
  }, {
    "id" : 80324,
    "reactomeId" : 10646939,
    "displayName" : "activated CASP4",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 795,
      "y" : 386
    },
    "minX" : 571,
    "maxX" : 852,
    "minY" : 100,
    "maxY" : 398,
    "prop" : {
      "x" : 744,
      "y" : 375,
      "width" : 102,
      "height" : 23
    },
    "textPosition" : {
      "x" : 760,
      "y" : 363
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 846,
          "y" : 375
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 846,
          "y" : 375
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80320,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 766,
          "y" : 372
        },
        "to" : {
          "x" : 575,
          "y" : 297
        }
      }, {
        "from" : {
          "x" : 575,
          "y" : 297
        },
        "to" : {
          "x" : 575,
          "y" : 108
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 575,
          "y" : 104
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 575,
          "y" : 104
        }
      }
    }, {
      "edgeId" : 80335,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 775,
          "y" : 372
        },
        "to" : {
          "x" : 706,
          "y" : 334
        }
      }, {
        "from" : {
          "x" : 706,
          "y" : 334
        },
        "to" : {
          "x" : 702,
          "y" : 267
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 702,
          "y" : 263
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 702,
          "y" : 263
        }
      }
    }, {
      "edgeId" : 80338,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 797,
          "y" : 372
        },
        "to" : {
          "x" : 841,
          "y" : 204
        }
      }, {
        "from" : {
          "x" : 841,
          "y" : 204
        },
        "to" : {
          "x" : 841,
          "y" : 197
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 841,
          "y" : 193
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 841,
          "y" : 193
        }
      }
    } ]
  }, {
    "id" : 80326,
    "reactomeId" : 10640289,
    "displayName" : "serpinb1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 193,
      "y" : 446
    },
    "minX" : 161,
    "maxX" : 231,
    "minY" : 429,
    "maxY" : 473,
    "prop" : {
      "x" : 161,
      "y" : 435,
      "width" : 64,
      "height" : 23
    },
    "textPosition" : {
      "x" : 161,
      "y" : 436
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 225,
          "y" : 435
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 225,
          "y" : 435
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80325,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 199,
          "y" : 461
        },
        "to" : {
          "x" : 209,
          "y" : 473
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80329,
    "reactomeId" : 10640283,
    "displayName" : "CASP5(1-434):LPS micelles",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 242,
      "y" : 386
    },
    "minX" : 182,
    "maxX" : 308,
    "minY" : 352,
    "maxY" : 405,
    "prop" : {
      "x" : 182,
      "y" : 368,
      "width" : 120,
      "height" : 37
    },
    "textPosition" : {
      "x" : 180,
      "y" : 370
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 302,
          "y" : 368
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 302,
          "y" : 368
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80327,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80330,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 257,
          "y" : 365
        },
        "to" : {
          "x" : 271,
          "y" : 352
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80328,
    "reactomeId" : 10640281,
    "displayName" : "Homologues of CASP5(1-434)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 84,
      "y" : 353
    },
    "minX" : 38,
    "maxX" : 271,
    "minY" : 342,
    "maxY" : 385,
    "prop" : {
      "x" : 38,
      "y" : 342,
      "width" : 93,
      "height" : 23
    },
    "textPosition" : {
      "x" : 39,
      "y" : 329
    },
    "connectors" : [ {
      "edgeId" : 80327,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 96,
          "y" : 368
        },
        "to" : {
          "x" : 118,
          "y" : 385
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80330,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 134,
          "y" : 352
        },
        "to" : {
          "x" : 271,
          "y" : 352
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80331,
    "reactomeId" : 10646810,
    "displayName" : "2xCASP5:LPS micelles",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 367,
      "y" : 352
    },
    "minX" : 323,
    "maxX" : 448,
    "minY" : 328,
    "maxY" : 371,
    "prop" : {
      "x" : 323,
      "y" : 334,
      "width" : 88,
      "height" : 37
    },
    "textPosition" : {
      "x" : 321,
      "y" : 336
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 411,
          "y" : 334
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 411,
          "y" : 334
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80330,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80332,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80332,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 414,
          "y" : 338
        },
        "to" : {
          "x" : 444,
          "y" : 328
        }
      }, {
        "from" : {
          "x" : 444,
          "y" : 328
        },
        "to" : {
          "x" : 444,
          "y" : 335
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 444,
          "y" : 339
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 444,
          "y" : 339
        }
      }
    } ]
  }, {
    "id" : 80333,
    "reactomeId" : 10646830,
    "displayName" : "activated CASP5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 558,
      "y" : 352
    },
    "minX" : 473,
    "maxX" : 665,
    "minY" : 69,
    "maxY" : 364,
    "prop" : {
      "x" : 507,
      "y" : 341,
      "width" : 102,
      "height" : 23
    },
    "textPosition" : {
      "x" : 523,
      "y" : 329
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 609,
          "y" : 341
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 609,
          "y" : 341
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80332,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 504,
          "y" : 351
        },
        "to" : {
          "x" : 473,
          "y" : 351
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 497,
          "y" : 355
        },
        "b" : {
          "x" : 504,
          "y" : 351
        },
        "c" : {
          "x" : 497,
          "y" : 347
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 497,
          "y" : 347
        }
      }
    }, {
      "edgeId" : 80334,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 557,
          "y" : 338
        },
        "to" : {
          "x" : 557,
          "y" : 77
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 557,
          "y" : 73
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 557,
          "y" : 73
        }
      }
    }, {
      "edgeId" : 80341,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 612,
          "y" : 352
        },
        "to" : {
          "x" : 662,
          "y" : 352
        }
      }, {
        "from" : {
          "x" : 662,
          "y" : 352
        },
        "to" : {
          "x" : 661,
          "y" : 265
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 661,
          "y" : 261
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 661,
          "y" : 261
        }
      }
    } ]
  }, {
    "id" : 80337,
    "reactomeId" : 10647204,
    "displayName" : "il1fma",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 780,
      "y" : 208
    },
    "minX" : 744,
    "maxX" : 822,
    "minY" : 191,
    "maxY" : 220,
    "prop" : {
      "x" : 744,
      "y" : 197,
      "width" : 72,
      "height" : 23
    },
    "textPosition" : {
      "x" : 757,
      "y" : 198
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 816,
          "y" : 197
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 816,
          "y" : 197
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80335,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80341,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80336,
    "reactomeId" : 10586859,
    "displayName" : "il1fma",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 634,
      "y" : 208
    },
    "minX" : 594,
    "maxX" : 680,
    "minY" : 191,
    "maxY" : 220,
    "prop" : {
      "x" : 594,
      "y" : 197,
      "width" : 80,
      "height" : 23
    },
    "textPosition" : {
      "x" : 611,
      "y" : 198
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 674,
          "y" : 197
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 674,
          "y" : 197
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80335,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80338,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80341,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80339,
    "reactomeId" : 10586865,
    "displayName" : "il1fma",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 924,
      "y" : 150
    },
    "minX" : 869,
    "maxX" : 978,
    "minY" : 133,
    "maxY" : 181,
    "prop" : {
      "x" : 876,
      "y" : 139,
      "width" : 96,
      "height" : 23
    },
    "textPosition" : {
      "x" : 901,
      "y" : 140
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 972,
          "y" : 139
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 972,
          "y" : 139
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80338,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 903,
          "y" : 165
        },
        "to" : {
          "x" : 869,
          "y" : 181
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 898,
          "y" : 172
        },
        "b" : {
          "x" : 903,
          "y" : 165
        },
        "c" : {
          "x" : 895,
          "y" : 164
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 895,
          "y" : 164
        }
      }
    } ]
  }, {
    "id" : 80309,
    "reactomeId" : 9686105,
    "displayName" : "LPS micelles",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 89,
      "y" : 421
    },
    "minX" : 46,
    "maxX" : 475,
    "minY" : 351,
    "maxY" : 507,
    "prop" : {
      "x" : 46,
      "y" : 406,
      "width" : 86,
      "height" : 31
    },
    "textPosition" : {
      "x" : 47,
      "y" : 411
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 127,
          "y" : 411
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 127,
          "y" : 411
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80327,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 101,
          "y" : 403
        },
        "to" : {
          "x" : 118,
          "y" : 385
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80332,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 135,
          "y" : 419
        },
        "to" : {
          "x" : 475,
          "y" : 404
        }
      }, {
        "from" : {
          "x" : 475,
          "y" : 404
        },
        "to" : {
          "x" : 473,
          "y" : 351
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 142,
          "y" : 415
        },
        "b" : {
          "x" : 135,
          "y" : 419
        },
        "c" : {
          "x" : 142,
          "y" : 423
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 142,
          "y" : 423
        }
      }
    }, {
      "edgeId" : 80308,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 108,
          "y" : 440
        },
        "to" : {
          "x" : 199,
          "y" : 507
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80340,
    "reactomeId" : 10586871,
    "displayName" : "il1fma",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 918,
      "y" : 220
    },
    "minX" : 869,
    "maxX" : 964,
    "minY" : 181,
    "maxY" : 232,
    "prop" : {
      "x" : 878,
      "y" : 209,
      "width" : 80,
      "height" : 23
    },
    "textPosition" : {
      "x" : 895,
      "y" : 210
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 958,
          "y" : 209
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 958,
          "y" : 209
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80338,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 903,
          "y" : 206
        },
        "to" : {
          "x" : 869,
          "y" : 181
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 895,
          "y" : 205
        },
        "b" : {
          "x" : 903,
          "y" : 206
        },
        "c" : {
          "x" : 900,
          "y" : 199
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 900,
          "y" : 199
        }
      }
    } ]
  }, {
    "id" : 80311,
    "reactomeId" : 10640267,
    "displayName" : "CASP4:LPS micelles",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 309,
      "y" : 511
    },
    "minX" : 250,
    "maxX" : 375,
    "minY" : 494,
    "maxY" : 547,
    "prop" : {
      "x" : 250,
      "y" : 500,
      "width" : 119,
      "height" : 23
    },
    "textPosition" : {
      "x" : 270,
      "y" : 488
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 369,
          "y" : 500
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 369,
          "y" : 500
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80308,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80312,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 323,
          "y" : 526
        },
        "to" : {
          "x" : 355,
          "y" : 547
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80310,
    "reactomeId" : 10640265,
    "displayName" : "caspa",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 93,
      "y" : 550
    },
    "minX" : 48,
    "maxX" : 375,
    "minY" : 473,
    "maxY" : 658,
    "prop" : {
      "x" : 48,
      "y" : 539,
      "width" : 90,
      "height" : 23
    },
    "textPosition" : {
      "x" : 70,
      "y" : 540
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 138,
          "y" : 539
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 138,
          "y" : 539
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80325,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 110,
          "y" : 536
        },
        "to" : {
          "x" : 209,
          "y" : 473
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80308,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 121,
          "y" : 536
        },
        "to" : {
          "x" : 199,
          "y" : 507
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80312,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 141,
          "y" : 549
        },
        "to" : {
          "x" : 355,
          "y" : 547
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80315,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 102,
          "y" : 565
        },
        "to" : {
          "x" : 180,
          "y" : 658
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80318,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 141,
          "y" : 559
        },
        "to" : {
          "x" : 375,
          "y" : 610
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80345,
    "reactomeId" : 10648016,
    "displayName" : "Pyroptosis",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 313,
      "y" : 44
    },
    "minX" : 275,
    "maxX" : 351,
    "minY" : 29,
    "maxY" : 60,
    "prop" : {
      "x" : 275,
      "y" : 29,
      "width" : 76,
      "height" : 31
    },
    "textPosition" : {
      "x" : 276,
      "y" : 23
    },
    "connectors" : [ ]
  }, {
    "id" : 80313,
    "reactomeId" : 10640287,
    "displayName" : "2xCASP4:LPS micelles",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 505,
      "y" : 549
    },
    "minX" : 461,
    "maxX" : 555,
    "minY" : 525,
    "maxY" : 568,
    "prop" : {
      "x" : 461,
      "y" : 531,
      "width" : 88,
      "height" : 37
    },
    "textPosition" : {
      "x" : 459,
      "y" : 533
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 549,
          "y" : 531
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 549,
          "y" : 531
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80312,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80344,
    "reactomeId" : 10650780,
    "displayName" : "GBP-mediated host defense",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 90,
      "y" : 747
    },
    "minX" : 23,
    "maxX" : 157,
    "minY" : 725,
    "maxY" : 770,
    "prop" : {
      "x" : 23,
      "y" : 725,
      "width" : 134,
      "height" : 45
    },
    "textPosition" : {
      "x" : 36,
      "y" : 726
    },
    "connectors" : [ ]
  }, {
    "id" : 80314,
    "reactomeId" : 10640291,
    "displayName" : "CASP4:SERPINB1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 417,
      "y" : 473
    },
    "minX" : 365,
    "maxX" : 476,
    "minY" : 456,
    "maxY" : 599,
    "prop" : {
      "x" : 365,
      "y" : 462,
      "width" : 105,
      "height" : 23
    },
    "textPosition" : {
      "x" : 383,
      "y" : 450
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 470,
          "y" : 462
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 470,
          "y" : 462
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80325,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80312,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 408,
          "y" : 488
        },
        "to" : {
          "x" : 378,
          "y" : 529
        }
      }, {
        "from" : {
          "x" : 378,
          "y" : 529
        },
        "to" : {
          "x" : 378,
          "y" : 538
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 374,
          "y" : 538
        },
        "b" : {
          "x" : 382,
          "y" : 538
        },
        "c" : {
          "x" : 378,
          "y" : 538
        },
        "type" : "STOP",
        "centre" : {
          "x" : 378,
          "y" : 538
        }
      }
    }, {
      "edgeId" : 80318,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 417,
          "y" : 488
        },
        "to" : {
          "x" : 418,
          "y" : 599
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 414,
          "y" : 599
        },
        "b" : {
          "x" : 422,
          "y" : 599
        },
        "c" : {
          "x" : 418,
          "y" : 599
        },
        "type" : "STOP",
        "centre" : {
          "x" : 418,
          "y" : 599
        }
      }
    } ]
  }, {
    "id" : 80317,
    "reactomeId" : 10646918,
    "displayName" : "CASP4:LPS:(GBP1:GBP2:GBP3:GBP4:GDP) oligomer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 321,
      "y" : 658
    },
    "minX" : 264,
    "maxX" : 384,
    "minY" : 610,
    "maxY" : 684,
    "prop" : {
      "x" : 264,
      "y" : 633,
      "width" : 114,
      "height" : 51
    },
    "textPosition" : {
      "x" : 263,
      "y" : 621
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 378,
          "y" : 633
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 378,
          "y" : 633
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80315,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 80318,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 349,
          "y" : 630
        },
        "to" : {
          "x" : 375,
          "y" : 610
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80316,
    "reactomeId" : 10646895,
    "displayName" : "LPS:(GBP1:GBP2:GBP3:GBP4) oligomer",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 91,
      "y" : 660
    },
    "minX" : 38,
    "maxX" : 180,
    "minY" : 635,
    "maxY" : 686,
    "prop" : {
      "x" : 38,
      "y" : 635,
      "width" : 106,
      "height" : 51
    },
    "textPosition" : {
      "x" : 39,
      "y" : 636
    },
    "connectors" : [ {
      "edgeId" : 80315,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 147,
          "y" : 658
        },
        "to" : {
          "x" : 180,
          "y" : 658
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 80319,
    "reactomeId" : 10646924,
    "displayName" : "2xCASP4:LPS:(GBP1:GBP2:GBP3:GBP4:GDP) oligomer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 471,
      "y" : 749
    },
    "minX" : 408,
    "maxX" : 541,
    "minY" : 718,
    "maxY" : 775,
    "prop" : {
      "x" : 408,
      "y" : 724,
      "width" : 127,
      "height" : 51
    },
    "textPosition" : {
      "x" : 409,
      "y" : 712
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 535,
          "y" : 724
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 535,
          "y" : 724
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 80318,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 80320,
    "reactomeId" : 10646942,
    "displayName" : "CASP4 cleaves IL18 at D36",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 575,
      "y" : 92
    },
    "minX" : 502,
    "maxX" : 606,
    "minY" : 72,
    "maxY" : 98,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 502,
        "y" : 72
      },
      "to" : {
        "x" : 575,
        "y" : 92
      }
    }, {
      "from" : {
        "x" : 575,
        "y" : 92
      },
      "to" : {
        "x" : 606,
        "y" : 92
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 569,
        "y" : 86
      },
      "b" : {
        "x" : 581,
        "y" : 98
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 575,
        "y" : 92
      }
    },
    "inputs" : [ {
      "id" : 80321
    } ],
    "outputs" : [ {
      "id" : 80322,
      "points" : [ {
        "x" : 685,
        "y" : 73
      } ]
    }, {
      "id" : 80323,
      "points" : [ {
        "x" : 663,
        "y" : 108
      } ]
    } ],
    "catalysts" : [ {
      "id" : 80324,
      "points" : [ {
        "x" : 766,
        "y" : 372
      }, {
        "x" : 575,
        "y" : 297
      } ]
    } ]
  }, {
    "id" : 80325,
    "reactomeId" : 10646968,
    "displayName" : "SERPINB1 binds CASP4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 254,
      "y" : 473
    },
    "minX" : 209,
    "maxX" : 362,
    "minY" : 467,
    "maxY" : 479,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 209,
        "y" : 473
      },
      "to" : {
        "x" : 254,
        "y" : 473
      }
    }, {
      "from" : {
        "x" : 254,
        "y" : 473
      },
      "to" : {
        "x" : 362,
        "y" : 473
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 355,
        "y" : 477
      },
      "b" : {
        "x" : 362,
        "y" : 473
      },
      "c" : {
        "x" : 355,
        "y" : 469
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 355,
        "y" : 469
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 254,
        "y" : 473
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 254,
        "y" : 473
      }
    },
    "inputs" : [ {
      "id" : 80326,
      "points" : [ {
        "x" : 199,
        "y" : 461
      } ]
    }, {
      "id" : 80310,
      "points" : [ {
        "x" : 110,
        "y" : 536
      } ]
    } ],
    "outputs" : [ {
      "id" : 80314
    } ]
  }, {
    "id" : 80327,
    "reactomeId" : 10640285,
    "displayName" : "CASP5 binds LPS micelles",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 147,
      "y" : 385
    },
    "minX" : 118,
    "maxX" : 179,
    "minY" : 379,
    "maxY" : 391,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 118,
        "y" : 385
      },
      "to" : {
        "x" : 147,
        "y" : 385
      }
    }, {
      "from" : {
        "x" : 147,
        "y" : 385
      },
      "to" : {
        "x" : 179,
        "y" : 385
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 172,
        "y" : 389
      },
      "b" : {
        "x" : 179,
        "y" : 385
      },
      "c" : {
        "x" : 172,
        "y" : 381
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 172,
        "y" : 381
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 147,
        "y" : 385
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 147,
        "y" : 385
      }
    },
    "inputs" : [ {
      "id" : 80309,
      "points" : [ {
        "x" : 101,
        "y" : 403
      } ]
    }, {
      "id" : 80328,
      "points" : [ {
        "x" : 96,
        "y" : 368
      } ]
    } ],
    "outputs" : [ {
      "id" : 80329
    } ]
  }, {
    "id" : 80330,
    "reactomeId" : 10646922,
    "displayName" : "CASP5 dimerizes",
    "schemaClass" : "Polymerisation",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 293,
      "y" : 352
    },
    "minX" : 271,
    "maxX" : 320,
    "minY" : 346,
    "maxY" : 358,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 271,
        "y" : 352
      },
      "to" : {
        "x" : 293,
        "y" : 352
      }
    }, {
      "from" : {
        "x" : 293,
        "y" : 352
      },
      "to" : {
        "x" : 320,
        "y" : 352
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 313,
        "y" : 356
      },
      "b" : {
        "x" : 320,
        "y" : 352
      },
      "c" : {
        "x" : 313,
        "y" : 348
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 313,
        "y" : 348
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 293,
        "y" : 352
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 293,
        "y" : 352
      }
    },
    "inputs" : [ {
      "id" : 80328,
      "points" : [ {
        "x" : 134,
        "y" : 352
      } ]
    }, {
      "id" : 80329,
      "points" : [ {
        "x" : 257,
        "y" : 365
      } ]
    } ],
    "outputs" : [ {
      "id" : 80331
    } ]
  }, {
    "id" : 80332,
    "reactomeId" : 10646833,
    "displayName" : "CASP5 autocatalysis on LPS micelles",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 445,
      "y" : 351
    },
    "minX" : 414,
    "maxX" : 473,
    "minY" : 345,
    "maxY" : 357,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 414,
        "y" : 351
      },
      "to" : {
        "x" : 445,
        "y" : 351
      }
    }, {
      "from" : {
        "x" : 445,
        "y" : 351
      },
      "to" : {
        "x" : 473,
        "y" : 351
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 439,
        "y" : 345
      },
      "b" : {
        "x" : 451,
        "y" : 357
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 445,
        "y" : 351
      }
    },
    "inputs" : [ {
      "id" : 80331
    } ],
    "outputs" : [ {
      "id" : 80333,
      "points" : [ {
        "x" : 504,
        "y" : 351
      } ]
    }, {
      "id" : 80309,
      "points" : [ {
        "x" : 135,
        "y" : 419
      }, {
        "x" : 475,
        "y" : 404
      } ]
    } ],
    "catalysts" : [ {
      "id" : 80331,
      "points" : [ {
        "x" : 414,
        "y" : 338
      }, {
        "x" : 444,
        "y" : 328
      } ]
    } ]
  }, {
    "id" : 80335,
    "reactomeId" : 10647206,
    "displayName" : "CASP4 cleaves IL1B at D27",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 701,
      "y" : 251
    },
    "minX" : 651,
    "maxX" : 758,
    "minY" : 223,
    "maxY" : 257,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 651,
        "y" : 223
      },
      "to" : {
        "x" : 701,
        "y" : 251
      }
    }, {
      "from" : {
        "x" : 701,
        "y" : 251
      },
      "to" : {
        "x" : 758,
        "y" : 223
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 754,
        "y" : 230
      },
      "b" : {
        "x" : 758,
        "y" : 223
      },
      "c" : {
        "x" : 750,
        "y" : 222
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 750,
        "y" : 222
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 695,
        "y" : 245
      },
      "b" : {
        "x" : 707,
        "y" : 257
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 701,
        "y" : 251
      }
    },
    "inputs" : [ {
      "id" : 80336
    } ],
    "outputs" : [ {
      "id" : 80337
    } ],
    "catalysts" : [ {
      "id" : 80324,
      "points" : [ {
        "x" : 775,
        "y" : 372
      }, {
        "x" : 706,
        "y" : 334
      } ]
    } ]
  }, {
    "id" : 80334,
    "reactomeId" : 10646931,
    "displayName" : "CASP5 cleaves IL18 at D36",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 557,
      "y" : 61
    },
    "minX" : 502,
    "maxX" : 614,
    "minY" : 55,
    "maxY" : 67,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 502,
        "y" : 61
      },
      "to" : {
        "x" : 557,
        "y" : 61
      }
    }, {
      "from" : {
        "x" : 557,
        "y" : 61
      },
      "to" : {
        "x" : 614,
        "y" : 61
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 551,
        "y" : 55
      },
      "b" : {
        "x" : 563,
        "y" : 67
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 557,
        "y" : 61
      }
    },
    "inputs" : [ {
      "id" : 80321
    } ],
    "outputs" : [ {
      "id" : 80322,
      "points" : [ {
        "x" : 685,
        "y" : 62
      } ]
    }, {
      "id" : 80323,
      "points" : [ {
        "x" : 684,
        "y" : 105
      } ]
    } ],
    "catalysts" : [ {
      "id" : 80333,
      "points" : [ {
        "x" : 557,
        "y" : 338
      } ]
    } ]
  }, {
    "id" : 80338,
    "reactomeId" : 10647253,
    "displayName" : "CASP4 cleaves IL1B at D116",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 841,
      "y" : 181
    },
    "minX" : 648,
    "maxX" : 869,
    "minY" : 175,
    "maxY" : 194,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 648,
        "y" : 194
      },
      "to" : {
        "x" : 668,
        "y" : 181
      }
    }, {
      "from" : {
        "x" : 668,
        "y" : 181
      },
      "to" : {
        "x" : 841,
        "y" : 181
      }
    }, {
      "from" : {
        "x" : 841,
        "y" : 181
      },
      "to" : {
        "x" : 869,
        "y" : 181
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 835,
        "y" : 175
      },
      "b" : {
        "x" : 847,
        "y" : 187
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 841,
        "y" : 181
      }
    },
    "inputs" : [ {
      "id" : 80336
    } ],
    "outputs" : [ {
      "id" : 80339,
      "points" : [ {
        "x" : 903,
        "y" : 165
      } ]
    }, {
      "id" : 80340,
      "points" : [ {
        "x" : 903,
        "y" : 206
      } ]
    } ],
    "catalysts" : [ {
      "id" : 80324,
      "points" : [ {
        "x" : 797,
        "y" : 372
      }, {
        "x" : 841,
        "y" : 204
      } ]
    } ]
  }, {
    "id" : 80341,
    "reactomeId" : 10647251,
    "displayName" : "CASP5 cleaves IL1B at D27",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 661,
      "y" : 249
    },
    "minX" : 641,
    "maxX" : 746,
    "minY" : 223,
    "maxY" : 255,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 641,
        "y" : 223
      },
      "to" : {
        "x" : 661,
        "y" : 249
      }
    }, {
      "from" : {
        "x" : 661,
        "y" : 249
      },
      "to" : {
        "x" : 746,
        "y" : 223
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 741,
        "y" : 229
      },
      "b" : {
        "x" : 746,
        "y" : 223
      },
      "c" : {
        "x" : 738,
        "y" : 221
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 738,
        "y" : 221
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 655,
        "y" : 243
      },
      "b" : {
        "x" : 667,
        "y" : 255
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 661,
        "y" : 249
      }
    },
    "inputs" : [ {
      "id" : 80336
    } ],
    "outputs" : [ {
      "id" : 80337
    } ],
    "catalysts" : [ {
      "id" : 80333,
      "points" : [ {
        "x" : 612,
        "y" : 352
      }, {
        "x" : 662,
        "y" : 352
      } ]
    } ]
  }, {
    "id" : 80308,
    "reactomeId" : 10640269,
    "displayName" : "CASP4 binds LPS micelles",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 215,
      "y" : 507
    },
    "minX" : 199,
    "maxX" : 247,
    "minY" : 501,
    "maxY" : 513,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 199,
        "y" : 507
      },
      "to" : {
        "x" : 215,
        "y" : 507
      }
    }, {
      "from" : {
        "x" : 215,
        "y" : 507
      },
      "to" : {
        "x" : 247,
        "y" : 508
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 240,
        "y" : 512
      },
      "b" : {
        "x" : 247,
        "y" : 508
      },
      "c" : {
        "x" : 240,
        "y" : 504
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 240,
        "y" : 504
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 215,
        "y" : 507
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 215,
        "y" : 507
      }
    },
    "inputs" : [ {
      "id" : 80309,
      "points" : [ {
        "x" : 108,
        "y" : 440
      } ]
    }, {
      "id" : 80310,
      "points" : [ {
        "x" : 121,
        "y" : 536
      } ]
    } ],
    "outputs" : [ {
      "id" : 80311
    } ]
  }, {
    "id" : 80312,
    "reactomeId" : 10640293,
    "displayName" : "CASP4 dimerizes",
    "schemaClass" : "Polymerisation",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 378,
      "y" : 547
    },
    "minX" : 355,
    "maxX" : 458,
    "minY" : 541,
    "maxY" : 553,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 355,
        "y" : 547
      },
      "to" : {
        "x" : 378,
        "y" : 547
      }
    }, {
      "from" : {
        "x" : 378,
        "y" : 547
      },
      "to" : {
        "x" : 458,
        "y" : 548
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 451,
        "y" : 552
      },
      "b" : {
        "x" : 458,
        "y" : 548
      },
      "c" : {
        "x" : 451,
        "y" : 544
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 451,
        "y" : 544
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 378,
        "y" : 547
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 378,
        "y" : 547
      }
    },
    "inputs" : [ {
      "id" : 80311,
      "points" : [ {
        "x" : 323,
        "y" : 526
      } ]
    }, {
      "id" : 80310,
      "points" : [ {
        "x" : 141,
        "y" : 549
      } ]
    } ],
    "outputs" : [ {
      "id" : 80313
    } ],
    "inhibitors" : [ {
      "id" : 80314,
      "points" : [ {
        "x" : 408,
        "y" : 488
      }, {
        "x" : 378,
        "y" : 529
      } ]
    } ]
  }, {
    "id" : 80315,
    "reactomeId" : 10646920,
    "displayName" : "CASP4 binds exposed LPS on the bacterial surface",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 214,
      "y" : 658
    },
    "minX" : 180,
    "maxX" : 261,
    "minY" : 652,
    "maxY" : 664,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 180,
        "y" : 658
      },
      "to" : {
        "x" : 214,
        "y" : 658
      }
    }, {
      "from" : {
        "x" : 214,
        "y" : 658
      },
      "to" : {
        "x" : 261,
        "y" : 658
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 254,
        "y" : 662
      },
      "b" : {
        "x" : 261,
        "y" : 658
      },
      "c" : {
        "x" : 254,
        "y" : 654
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 254,
        "y" : 654
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 214,
        "y" : 658
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 214,
        "y" : 658
      }
    },
    "inputs" : [ {
      "id" : 80316,
      "points" : [ {
        "x" : 147,
        "y" : 658
      } ]
    }, {
      "id" : 80310,
      "points" : [ {
        "x" : 102,
        "y" : 565
      } ]
    } ],
    "outputs" : [ {
      "id" : 80317
    } ]
  }, {
    "id" : 80318,
    "reactomeId" : 10646926,
    "displayName" : "CASP4 forms dimers on the bacterial surface",
    "schemaClass" : "Polymerisation",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 418,
      "y" : 608
    },
    "minX" : 375,
    "maxX" : 461,
    "minY" : 602,
    "maxY" : 721,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 375,
        "y" : 610
      },
      "to" : {
        "x" : 418,
        "y" : 608
      }
    }, {
      "from" : {
        "x" : 418,
        "y" : 608
      },
      "to" : {
        "x" : 461,
        "y" : 721
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 455,
        "y" : 716
      },
      "b" : {
        "x" : 461,
        "y" : 721
      },
      "c" : {
        "x" : 462,
        "y" : 713
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 462,
        "y" : 713
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 418,
        "y" : 608
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 418,
        "y" : 608
      }
    },
    "inputs" : [ {
      "id" : 80317,
      "points" : [ {
        "x" : 349,
        "y" : 630
      } ]
    }, {
      "id" : 80310,
      "points" : [ {
        "x" : 141,
        "y" : 559
      } ]
    } ],
    "outputs" : [ {
      "id" : 80319
    } ],
    "inhibitors" : [ {
      "id" : 80314,
      "points" : [ {
        "x" : 417,
        "y" : 488
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 80342,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 502,
      "y" : 474
    },
    "minX" : 0,
    "maxX" : 1004,
    "minY" : 0,
    "maxY" : 948,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1004,
      "height" : 948
    },
    "textPosition" : {
      "x" : 782,
      "y" : 13
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 984,
      "height" : 928
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 80308, 80311, 80309, 80310, 80312, 80313, 80314, 80324, 80315, 80317, 80318, 80319, 80344, 80320, 80325, 80326, 80329, 80327, 80328, 80330, 80331, 80332, 80333, 80334, 80345, 80346, 80347, 80335, 80336, 80337, 80316, 80348, 80349, 80350, 80321, 80322, 80323, 80338, 80339, 80340, 80341 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 80349,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 90,
      "y" : 705
    },
    "minX" : 84,
    "maxX" : 96,
    "minY" : 689,
    "maxY" : 722,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 90,
        "y" : 689
      },
      "to" : {
        "x" : 90,
        "y" : 722
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 86,
        "y" : 715
      },
      "b" : {
        "x" : 90,
        "y" : 722
      },
      "c" : {
        "x" : 94,
        "y" : 715
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 94,
        "y" : 715
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 84,
        "y" : 699
      },
      "b" : {
        "x" : 96,
        "y" : 711
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 90,
        "y" : 705
      }
    },
    "inputs" : [ {
      "id" : 80316
    } ],
    "outputs" : [ {
      "id" : 80344
    } ]
  } ],
  "shadows" : [ {
    "id" : 80353,
    "reactomeId" : 10650784,
    "displayName" : "CASP4-mediated substrate cleavage",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 695,
      "y" : 224
    },
    "minX" : 408,
    "maxX" : 982,
    "minY" : 41,
    "maxY" : 408,
    "prop" : {
      "x" : 826,
      "y" : 41,
      "width" : 156,
      "height" : 333
    },
    "points" : [ {
      "x" : 408,
      "y" : 41
    }, {
      "x" : 982,
      "y" : 41
    }, {
      "x" : 982,
      "y" : 408
    }, {
      "x" : 408,
      "y" : 408
    } ],
    "colour" : "#666666"
  }, {
    "id" : 80352,
    "reactomeId" : 10650782,
    "displayName" : "CASP5-mediated substrate cleavage",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 617,
      "y" : 207
    },
    "minX" : 408,
    "maxX" : 826,
    "minY" : 41,
    "maxY" : 374,
    "prop" : {
      "x" : 408,
      "y" : 41,
      "width" : 418,
      "height" : 283
    },
    "points" : [ {
      "x" : 408,
      "y" : 41
    }, {
      "x" : 826,
      "y" : 41
    }, {
      "x" : 826,
      "y" : 374
    }, {
      "x" : 408,
      "y" : 374
    } ],
    "colour" : "#008000"
  }, {
    "id" : 80351,
    "reactomeId" : 10650570,
    "displayName" : "CASP5 inflammasome assembly",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 323,
      "y" : 385
    },
    "minX" : 28,
    "maxX" : 619,
    "minY" : 324,
    "maxY" : 447,
    "prop" : {
      "x" : 28,
      "y" : 324,
      "width" : 380,
      "height" : 72
    },
    "points" : [ {
      "x" : 28,
      "y" : 324
    }, {
      "x" : 619,
      "y" : 324
    }, {
      "x" : 619,
      "y" : 447
    }, {
      "x" : 28,
      "y" : 447
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 80350,
    "reactomeId" : 10650566,
    "displayName" : "CASP4 inflammasome assembly",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 293,
      "y" : 590
    },
    "minX" : 28,
    "maxX" : 559,
    "minY" : 396,
    "maxY" : 785,
    "prop" : {
      "x" : 28,
      "y" : 447,
      "width" : 531,
      "height" : 338
    },
    "points" : [ {
      "x" : 28,
      "y" : 396
    }, {
      "x" : 559,
      "y" : 396
    }, {
      "x" : 559,
      "y" : 785
    }, {
      "x" : 28,
      "y" : 785
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1004,
  "minY" : 0,
  "maxY" : 948,
  "disease" : false
}