{
  "dbId" : 10648674,
  "stId" : "R-DRE-9614085",
  "speciesName" : "Danio rerio",
  "nodes" : [ {
    "dbId" : 10575136,
    "stId" : "R-DRE-198357",
    "displayName" : "phospho-p-T308,S473-AKT1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "E7EXT6",
    "standardIdentifier" : "uniprot:E7EXT6",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10575142 ],
    "children" : [ ]
  }, {
    "dbId" : 10650528,
    "stId" : "R-DRE-9617828",
    "displayName" : "FOXO-mediated transcription of cell cycle genes",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 29024 ]
  }, {
    "dbId" : 10575138,
    "stId" : "R-DRE-202087",
    "displayName" : "phospho-p-T309,S474-AKT2 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q8UUX0",
    "standardIdentifier" : "uniprot:Q8UUX0",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10575142 ],
    "children" : [ ]
  }, {
    "dbId" : 10575140,
    "stId" : "R-DRE-3009365",
    "displayName" : "phospho-p-T305,S472-AKT3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "E7EXT6",
    "standardIdentifier" : "uniprot:E7EXT6",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10575142 ],
    "children" : [ ]
  }, {
    "dbId" : 427523,
    "stId" : "R-ALL-427523",
    "displayName" : "NAD+ [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 29011 ],
    "identifier" : "57540",
    "standardIdentifier" : "chebi:57540",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10575142,
    "stId" : "R-DRE-202072",
    "displayName" : "p-T,p-S-AKT [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 68323,
    "diagramIds" : [ 28991 ],
    "parents" : [ ],
    "children" : [ 10575136, 10575140, 10575138 ]
  }, {
    "dbId" : 10575149,
    "stId" : "R-DRE-199300",
    "displayName" : "foxo1a [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 29025 ],
    "identifier" : "A3RK74",
    "standardIdentifier" : "uniprot:A3RK74",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "foxo1a" ],
    "parents" : [ 10575163 ],
    "children" : [ ]
  }, {
    "dbId" : 10575153,
    "stId" : "R-DRE-199305",
    "displayName" : "foxo3b [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 29004 ],
    "identifier" : "Q9W7F8",
    "standardIdentifier" : "uniprot:Q9W7F8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "foxo3b" ],
    "parents" : [ 10575163 ],
    "children" : [ ]
  }, {
    "dbId" : 10575157,
    "stId" : "R-DRE-5690183",
    "displayName" : "foxo4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 29019 ],
    "identifier" : "F1R3E6",
    "standardIdentifier" : "uniprot:F1R3E6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "foxo4" ],
    "parents" : [ 10575163 ],
    "children" : [ ]
  }, {
    "dbId" : 10575161,
    "stId" : "R-DRE-9614396",
    "displayName" : "foxo6b [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "F1R4K6",
    "standardIdentifier" : "uniprot:F1R4K6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "foxo6b" ],
    "parents" : [ 10575163 ],
    "children" : [ ]
  }, {
    "dbId" : 113560,
    "stId" : "R-ALL-113560",
    "displayName" : "Ac-CoA [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 29005 ],
    "identifier" : "57288",
    "standardIdentifier" : "chebi:57288",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10575163,
    "stId" : "R-DRE-199272",
    "displayName" : "FOXO1,FOXO3,FOXO4,(FOXO6) [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 68323,
    "diagramIds" : [ 28988 ],
    "parents" : [ ],
    "children" : [ 10575149, 10575157, 10575153, 10575161 ]
  }, {
    "dbId" : 10577921,
    "stId" : "R-DRE-352430",
    "displayName" : "KAT2B [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 29008 ],
    "identifier" : "Q1LUC3",
    "standardIdentifier" : "uniprot:Q1LUC3",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10577408,
    "stId" : "R-DRE-211158",
    "displayName" : "phospho-foxo1a [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 28996 ],
    "identifier" : "A3RK74",
    "standardIdentifier" : "uniprot:A3RK74",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "foxo1a" ],
    "parents" : [ 10638945, 10638939 ],
    "children" : [ ]
  }, {
    "dbId" : 10564354,
    "stId" : "R-DRE-1445105-2",
    "displayName" : "ywhaqb [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q803M8",
    "standardIdentifier" : "uniprot:Q803M8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ywhaqb" ],
    "parents" : [ 10564356 ],
    "children" : [ ]
  }, {
    "dbId" : 10564356,
    "stId" : "R-DRE-1445105-3",
    "displayName" : "Homologues of SFN [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "parents" : [ 10564358 ],
    "children" : [ 10564350, 10564354 ]
  }, {
    "dbId" : 10564358,
    "stId" : "R-DRE-2262716",
    "displayName" : "SFN dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "parents" : [ 10638949 ],
    "children" : [ 10564356 ]
  }, {
    "dbId" : 10564360,
    "stId" : "R-DRE-1445116",
    "displayName" : "ywhaqb [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q803M8",
    "standardIdentifier" : "uniprot:Q803M8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ywhaqb" ],
    "parents" : [ 10564362 ],
    "children" : [ ]
  }, {
    "dbId" : 10564362,
    "stId" : "R-DRE-2262714",
    "displayName" : "YWHAQ dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "parents" : [ 10638943, 10638949 ],
    "children" : [ 10564360 ]
  }, {
    "dbId" : 29358,
    "stId" : "R-ALL-29358",
    "displayName" : "ATP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 28987 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10564366,
    "stId" : "R-DRE-48888",
    "displayName" : "ywhaba [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q5PRD0",
    "standardIdentifier" : "uniprot:Q5PRD0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ywhaba" ],
    "parents" : [ 10564372 ],
    "children" : [ ]
  }, {
    "dbId" : 113582,
    "stId" : "R-ALL-113582",
    "displayName" : "ADP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 28989 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 2485002,
    "stId" : "R-ALL-2485002",
    "displayName" : "CoA-SH [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 29007 ],
    "identifier" : "57287",
    "standardIdentifier" : "chebi:57287",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10564370,
    "stId" : "R-DRE-48888-2",
    "displayName" : "ywhabb [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q7T356",
    "standardIdentifier" : "uniprot:Q7T356",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ywhabb" ],
    "parents" : [ 10564372 ],
    "children" : [ ]
  }, {
    "dbId" : 10564372,
    "stId" : "R-DRE-48888-3",
    "displayName" : "Homologues of YWHAB [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "parents" : [ 10564374 ],
    "children" : [ 10564366, 10564370 ]
  }, {
    "dbId" : 10564374,
    "stId" : "R-DRE-2028645",
    "displayName" : "YWHAB dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "parents" : [ 10638943 ],
    "children" : [ 10564372 ]
  }, {
    "dbId" : 10650526,
    "stId" : "R-DRE-9615017",
    "displayName" : "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 29023 ]
  }, {
    "dbId" : 10638945,
    "stId" : "R-DRE-9614572",
    "displayName" : "p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 28998 ],
    "parents" : [ ],
    "children" : [ 10638943, 10577408 ]
  }, {
    "dbId" : 10638951,
    "stId" : "R-DRE-9614628",
    "displayName" : "p-T32,S253,S315-FOXO3:YWHAZ,YWHAQ,SFN [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 29002 ],
    "parents" : [ ],
    "children" : [ 10638949, 10638935 ]
  }, {
    "dbId" : 10638949,
    "stId" : "R-DRE-9614627",
    "displayName" : "YWHAZ dimer,YWHAQ dimer,SFN dimer [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "diagramIds" : [ 29000 ],
    "parents" : [ 10638951 ],
    "children" : [ 10564362, 10564358 ]
  }, {
    "dbId" : 3785707,
    "stId" : "R-ALL-3785707",
    "displayName" : "ROS [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 29009 ],
    "identifier" : "26523",
    "standardIdentifier" : "chebi:26523",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10564338,
    "stId" : "R-DRE-380312",
    "displayName" : "ywhag2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "E7F354",
    "standardIdentifier" : "uniprot:E7F354",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ywhag2" ],
    "parents" : [ 10564344 ],
    "children" : [ ]
  }, {
    "dbId" : 10564342,
    "stId" : "R-DRE-380312-2",
    "displayName" : "ywhag1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6PC29",
    "standardIdentifier" : "uniprot:Q6PC29",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ywhag1" ],
    "parents" : [ 10564344 ],
    "children" : [ ]
  }, {
    "dbId" : 10564344,
    "stId" : "R-DRE-380312-3",
    "displayName" : "Homologues of YWHAG [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "parents" : [ 10564346 ],
    "children" : [ 10564342, 10564338 ]
  }, {
    "dbId" : 10564346,
    "stId" : "R-DRE-2262713",
    "displayName" : "YWHAG dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "parents" : [ 10638943 ],
    "children" : [ 10564344 ]
  }, {
    "dbId" : 10564350,
    "stId" : "R-DRE-1445105",
    "displayName" : "ywhaqa [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q7ZUM0",
    "standardIdentifier" : "uniprot:Q7ZUM0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ywhaqa" ],
    "parents" : [ 10564356 ],
    "children" : [ ]
  }, {
    "dbId" : 10575168,
    "stId" : "R-DRE-199306",
    "displayName" : "phospho-foxo1a [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A3RK74",
    "standardIdentifier" : "uniprot:A3RK74",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "foxo1a" ],
    "parents" : [ 10638933, 10575184 ],
    "children" : [ ]
  }, {
    "dbId" : 10575173,
    "stId" : "R-DRE-199289",
    "displayName" : "phospho-foxo3b [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q9W7F8",
    "standardIdentifier" : "uniprot:Q9W7F8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "foxo3b" ],
    "parents" : [ 10638933, 10575184 ],
    "children" : [ ]
  }, {
    "dbId" : 10639051,
    "stId" : "R-DRE-9620514",
    "displayName" : "foxo3b [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 29006 ],
    "identifier" : "Q9W7F8",
    "standardIdentifier" : "uniprot:Q9W7F8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "foxo3b" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10575178,
    "stId" : "R-DRE-199314",
    "displayName" : "phospho-foxo4 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "F1R3E6",
    "standardIdentifier" : "uniprot:F1R3E6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "foxo4" ],
    "parents" : [ 10638933, 10575184 ],
    "children" : [ ]
  }, {
    "dbId" : 427498,
    "stId" : "R-ALL-427498",
    "displayName" : "2'-O-acetyl-ADP-ribose [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 29012 ],
    "identifier" : "83767",
    "standardIdentifier" : "chebi:83767",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10575182,
    "stId" : "R-DRE-9614995",
    "displayName" : "phospho-foxo6b [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "F1R4K6",
    "standardIdentifier" : "uniprot:F1R4K6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "foxo6b" ],
    "parents" : [ 10575184 ],
    "children" : [ ]
  }, {
    "dbId" : 427497,
    "stId" : "R-ALL-427497",
    "displayName" : "NAM [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 29013 ],
    "identifier" : "17154",
    "standardIdentifier" : "chebi:17154",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10639058,
    "stId" : "R-DRE-9622899",
    "displayName" : "SIRT1,SIRT3 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "diagramIds" : [ 29014 ],
    "parents" : [ ],
    "children" : [ 10639056, 10584915 ]
  }, {
    "dbId" : 10575184,
    "stId" : "R-DRE-9614997",
    "displayName" : "p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 68323,
    "diagramIds" : [ 28990 ],
    "parents" : [ ],
    "children" : [ 10575178, 10575173, 10575168, 10575182 ]
  }, {
    "dbId" : 10584915,
    "stId" : "R-DRE-427531",
    "displayName" : "SIRT1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 29026 ],
    "identifier" : "E7F8W3",
    "standardIdentifier" : "uniprot:E7F8W3",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10639058 ],
    "children" : [ ]
  }, {
    "dbId" : 10639056,
    "stId" : "R-DRE-9622879",
    "displayName" : "SIRT3 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A0A2R8QMP7",
    "standardIdentifier" : "uniprot:A0A2R8QMP7",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10639058 ],
    "children" : [ ]
  }, {
    "dbId" : 10638935,
    "stId" : "R-DRE-9614413",
    "displayName" : "phospho-foxo3b [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 29001 ],
    "identifier" : "Q9W7F8",
    "standardIdentifier" : "uniprot:Q9W7F8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "foxo3b" ],
    "parents" : [ 10638939, 10638951 ],
    "children" : [ ]
  }, {
    "dbId" : 10638933,
    "stId" : "R-DRE-199269",
    "displayName" : "p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [nucleoplasm]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "diagramIds" : [ 28993 ],
    "parents" : [ ],
    "children" : [ 10575178, 10575173, 10575168 ]
  }, {
    "dbId" : 10638939,
    "stId" : "R-DRE-9614416",
    "displayName" : "p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "diagramIds" : [ 28994 ],
    "parents" : [ ],
    "children" : [ 10638937, 10638935, 10577408 ]
  }, {
    "dbId" : 10638937,
    "stId" : "R-DRE-9614415",
    "displayName" : "phospho-foxo4 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 29018 ],
    "identifier" : "F1R3E6",
    "standardIdentifier" : "uniprot:F1R3E6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "foxo4" ],
    "parents" : [ 10638939 ],
    "children" : [ ]
  }, {
    "dbId" : 10638943,
    "stId" : "R-DRE-9614573",
    "displayName" : "YWHAZ dimer,YWHAQ dimer,YWHAG dimer,YWHAB dimer [cytosol]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "diagramIds" : [ 28997 ],
    "parents" : [ 10638945 ],
    "children" : [ 10564346, 10564362, 10564374 ]
  }, {
    "dbId" : 10648028,
    "stId" : "R-DRE-1257604",
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "speciesId" : 68323,
    "diagramIds" : [ 29017 ]
  } ],
  "edges" : [ {
    "dbId" : 10638947,
    "stId" : "R-DRE-9614423",
    "displayName" : "14-3-3 proteins bind AKT-phosphorylated FOXO1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10638941 ],
    "inputs" : [ 10638943, 10577408 ],
    "outputs" : [ 10638945 ],
    "efs" : [ ],
    "diagramIds" : [ 28995 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10575186,
    "stId" : "R-DRE-199299",
    "displayName" : "AKT phosphorylates FOXO transcription factors",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10638941 ],
    "inputs" : [ 29358, 10575163 ],
    "outputs" : [ 113582, 10575184 ],
    "catalysts" : [ 10575142 ],
    "efs" : [ ],
    "diagramIds" : [ 28986 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10639061,
    "stId" : "R-DRE-9620532",
    "displayName" : "SIRT1,SIRT3 deacetylate FOXO3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10639054 ],
    "inputs" : [ 10639051, 427523 ],
    "outputs" : [ 427497, 427498, 10575153 ],
    "catalysts" : [ 10639058 ],
    "efs" : [ ],
    "diagramIds" : [ 29010 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10638953,
    "stId" : "R-DRE-9614562",
    "displayName" : "14-3-3 proteins bind AKT-phosphorylated FOXO3",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10638941 ],
    "inputs" : [ 10638949, 10638935 ],
    "outputs" : [ 10638951 ],
    "efs" : [ ],
    "diagramIds" : [ 28999 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10639054,
    "stId" : "R-DRE-9620515",
    "displayName" : "KAT2B,EP300 acetylate FOXO3 under oxidative stress",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10639061 ],
    "inputs" : [ 113560, 10575153 ],
    "outputs" : [ 2485002, 10639051 ],
    "catalysts" : [ 10577921 ],
    "efs" : [ ],
    "activators" : [ 3785707 ],
    "diagramIds" : [ 29003 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10638941,
    "stId" : "R-DRE-9614414",
    "displayName" : "AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10575186 ],
    "following" : [ 10638947, 10638953 ],
    "inputs" : [ 10638933 ],
    "outputs" : [ 10638939 ],
    "efs" : [ ],
    "diagramIds" : [ 28992 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10650532,
    "stId" : "R-DRE-9617629",
    "displayName" : "Regulation of FOXO transcriptional activity by acetylation",
    "events" : [ 10639061, 10639054 ]
  }, {
    "dbId" : 10648672,
    "stId" : "R-DRE-9614399",
    "displayName" : "Regulation of localization of FOXO transcription factors",
    "events" : [ 10638947, 10575186, 10638953, 10638941 ]
  } ]
}