{ "dbId" : 10649980, "stableId" : "R-DRE-9012999", "displayName" : "RHO GTPase cycle", "nodes" : [ { "id" : 94209, "reactomeId" : 10637616, "displayName" : "CDC42:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1569, "y" : 62 }, "minX" : 1469, "maxX" : 1663, "minY" : 44, "maxY" : 198, "prop" : { "x" : 1530, "y" : 50, "width" : 78, "height" : 25 }, "textPosition" : { "x" : 1542, "y" : 40 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1608, "y" : 50 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1608, "y" : 50 } } }, "connectors" : [ { "edgeId" : 94208, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1611, "y" : 63 }, "to" : { "x" : 1663, "y" : 66 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94214, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1569, "y" : 78 }, "to" : { "x" : 1577, "y" : 198 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1573, "y" : 85 }, "b" : { "x" : 1569, "y" : 78 }, "c" : { "x" : 1565, "y" : 85 }, "type" : "ARROW", "centre" : { "x" : 1565, "y" : 85 } } }, { "edgeId" : 94218, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1557, "y" : 78 }, "to" : { "x" : 1469, "y" : 174 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94211, "reactomeId" : 10572518, "displayName" : "CDC42:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1843, "y" : 63 }, "minX" : 1753, "maxX" : 1942, "minY" : 45, "maxY" : 189, "prop" : { "x" : 1801, "y" : 51, "width" : 85, "height" : 24 }, "textPosition" : { "x" : 1805, "y" : 54 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1886, "y" : 51 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1886, "y" : 51 } } }, "connectors" : [ { "edgeId" : 94208, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1798, "y" : 63 }, "to" : { "x" : 1753, "y" : 64 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1791, "y" : 67 }, "b" : { "x" : 1798, "y" : 63 }, "c" : { "x" : 1791, "y" : 59 }, "type" : "ARROW", "centre" : { "x" : 1791, "y" : 59 } } }, { "edgeId" : 94214, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1840, "y" : 78 }, "to" : { "x" : 1812, "y" : 189 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94221, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1858, "y" : 78 }, "to" : { "x" : 1942, "y" : 138 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94349, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94210, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1603, "y" : 116 }, "minX" : 1583, "maxX" : 1663, "minY" : 66, "maxY" : 131, "prop" : { "x" : 1583, "y" : 101, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1587, "y" : 105 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1619, "y" : 106 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1619, "y" : 106 } } }, "connectors" : [ { "edgeId" : 94208, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1621, "y" : 98 }, "to" : { "x" : 1663, "y" : 66 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94213, "reactomeId" : 10637628, "displayName" : "CDC42 GEFs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1697, "y" : 144 }, "minX" : 1656, "maxX" : 1738, "minY" : 74, "maxY" : 155, "prop" : { "x" : 1656, "y" : 133, "width" : 82, "height" : 22 }, "textPosition" : { "x" : 1670, "y" : 127 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94208, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1697, "y" : 127 }, "to" : { "x" : 1701, "y" : 82 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1702, "y" : 78 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1702, "y" : 78 } } } ] }, { "id" : 94212, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1783, "y" : 123 }, "minX" : 1753, "maxX" : 1805, "minY" : 64, "maxY" : 138, "prop" : { "x" : 1762, "y" : 108, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 1766, "y" : 112 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1799, "y" : 113 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1799, "y" : 113 } } }, "connectors" : [ { "edgeId" : 94208, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1775, "y" : 105 }, "to" : { "x" : 1753, "y" : 64 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1768, "y" : 101 }, "b" : { "x" : 1775, "y" : 105 }, "c" : { "x" : 1775, "y" : 97 }, "type" : "ARROW", "centre" : { "x" : 1775, "y" : 97 } } } ] }, { "id" : 94215, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1805, "y" : 268 }, "minX" : 1784, "maxX" : 1827, "minY" : 189, "maxY" : 282, "prop" : { "x" : 1784, "y" : 255, "width" : 42, "height" : 27 }, "textPosition" : { "x" : 1788, "y" : 258 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1821, "y" : 260 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1821, "y" : 260 } } }, "connectors" : [ { "edgeId" : 94214, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1806, "y" : 252 }, "to" : { "x" : 1812, "y" : 189 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 94217, "reactomeId" : 10637637, "displayName" : "CDC42 GAPs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1697, "y" : 291 }, "minX" : 1654, "maxX" : 1740, "minY" : 215, "maxY" : 303, "prop" : { "x" : 1654, "y" : 279, "width" : 86, "height" : 24 }, "textPosition" : { "x" : 1654, "y" : 280 }, "connectors" : [ { "edgeId" : 94214, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1697, "y" : 273 }, "to" : { "x" : 1698, "y" : 223 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1698, "y" : 219 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1698, "y" : 219 } } } ] }, { "id" : 94216, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1541, "y" : 265 }, "minX" : 1526, "maxX" : 1577, "minY" : 198, "maxY" : 277, "prop" : { "x" : 1526, "y" : 253, "width" : 31, "height" : 24 }, "textPosition" : { "x" : 1532, "y" : 254 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1552, "y" : 258 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1552, "y" : 258 } } }, "connectors" : [ { "edgeId" : 94214, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1547, "y" : 250 }, "to" : { "x" : 1577, "y" : 198 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1547, "y" : 242 }, "b" : { "x" : 1547, "y" : 250 }, "c" : { "x" : 1554, "y" : 246 }, "type" : "ARROW", "centre" : { "x" : 1554, "y" : 246 } } } ] }, { "id" : 94219, "reactomeId" : 10637618, "displayName" : "CDC42 GDIs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1407, "y" : 129 }, "minX" : 1365, "maxX" : 1469, "minY" : 118, "maxY" : 174, "prop" : { "x" : 1365, "y" : 118, "width" : 84, "height" : 23 }, "textPosition" : { "x" : 1366, "y" : 119 }, "connectors" : [ { "edgeId" : 94218, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1422, "y" : 147 }, "to" : { "x" : 1469, "y" : 174 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94220, "reactomeId" : 10637620, "displayName" : "CDC42:GDP:CDC42 GDIs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1463, "y" : 258 }, "minX" : 1421, "maxX" : 1512, "minY" : 233, "maxY" : 278, "prop" : { "x" : 1421, "y" : 239, "width" : 85, "height" : 39 }, "textPosition" : { "x" : 1422, "y" : 243 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1506, "y" : 239 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1506, "y" : 239 } } }, "connectors" : [ { "edgeId" : 94218, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94223, "reactomeId" : 10637612, "displayName" : "CDC42:GTP:CDC42 effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1947, "y" : 285 }, "minX" : 1893, "maxX" : 2008, "minY" : 261, "maxY" : 303, "prop" : { "x" : 1893, "y" : 267, "width" : 109, "height" : 36 }, "textPosition" : { "x" : 1893, "y" : 268 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2002, "y" : 267 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2002, "y" : 267 } } }, "connectors" : [ { "edgeId" : 94221, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94222, "reactomeId" : 10637610, "displayName" : "CDC42 effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2016, "y" : 169 }, "minX" : 1942, "maxX" : 2050, "minY" : 138, "maxY" : 187, "prop" : { "x" : 1982, "y" : 152, "width" : 68, "height" : 35 }, "textPosition" : { "x" : 1984, "y" : 152 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94221, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1976, "y" : 154 }, "to" : { "x" : 1942, "y" : 138 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94225, "reactomeId" : 10637790, "displayName" : "RHOJ:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3161, "y" : 952 }, "minX" : 2998, "maxX" : 3204, "minY" : 935, "maxY" : 1005, "prop" : { "x" : 3124, "y" : 941, "width" : 74, "height" : 23 }, "textPosition" : { "x" : 3127, "y" : 943 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3198, "y" : 941 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3198, "y" : 941 } } }, "connectors" : [ { "edgeId" : 94224, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3161, "y" : 967 }, "to" : { "x" : 3161, "y" : 1005 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94230, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3121, "y" : 955 }, "to" : { "x" : 2998, "y" : 969 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3115, "y" : 960 }, "b" : { "x" : 3121, "y" : 955 }, "c" : { "x" : 3114, "y" : 952 }, "type" : "ARROW", "centre" : { "x" : 3114, "y" : 952 } } } ] }, { "id" : 94227, "reactomeId" : 10637788, "displayName" : "RHOJ:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3158, "y" : 1136 }, "minX" : 2998, "maxX" : 3201, "minY" : 1079, "maxY" : 1148, "prop" : { "x" : 3122, "y" : 1124, "width" : 73, "height" : 24 }, "textPosition" : { "x" : 3126, "y" : 1127 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3195, "y" : 1124 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3195, "y" : 1124 } } }, "connectors" : [ { "edgeId" : 94224, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3158, "y" : 1121 }, "to" : { "x" : 3161, "y" : 1079 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3155, "y" : 1114 }, "b" : { "x" : 3158, "y" : 1121 }, "c" : { "x" : 3162, "y" : 1114 }, "type" : "ARROW", "centre" : { "x" : 3162, "y" : 1114 } } }, { "edgeId" : 94230, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3119, "y" : 1127 }, "to" : { "x" : 2998, "y" : 1099 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94226, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3095, "y" : 985 }, "minX" : 3076, "maxX" : 3161, "minY" : 974, "maxY" : 1005, "prop" : { "x" : 3076, "y" : 975, "width" : 39, "height" : 20 }, "textPosition" : { "x" : 3079, "y" : 975 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3110, "y" : 980 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3110, "y" : 980 } } }, "connectors" : [ { "edgeId" : 94224, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3118, "y" : 990 }, "to" : { "x" : 3161, "y" : 1005 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94229, "reactomeId" : 10637797, "displayName" : "RHOJ GEFs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 3075, "y" : 1037 }, "minX" : 3040, "maxX" : 3153, "minY" : 1026, "maxY" : 1048, "prop" : { "x" : 3040, "y" : 1026, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 3055, "y" : 1020 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94224, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3117, "y" : 1035 }, "to" : { "x" : 3145, "y" : 1034 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3149, "y" : 1034 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3149, "y" : 1034 } } } ] }, { "id" : 94228, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3099, "y" : 1087 }, "minX" : 3079, "maxX" : 3161, "minY" : 1074, "maxY" : 1099, "prop" : { "x" : 3079, "y" : 1075, "width" : 40, "height" : 24 }, "textPosition" : { "x" : 3082, "y" : 1076 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3114, "y" : 1080 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3114, "y" : 1080 } } }, "connectors" : [ { "edgeId" : 94224, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3122, "y" : 1084 }, "to" : { "x" : 3161, "y" : 1079 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3128, "y" : 1079 }, "b" : { "x" : 3122, "y" : 1084 }, "c" : { "x" : 3129, "y" : 1087 }, "type" : "ARROW", "centre" : { "x" : 3129, "y" : 1087 } } } ] }, { "id" : 94231, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2946, "y" : 1128 }, "minX" : 2926, "maxX" : 2998, "minY" : 1099, "maxY" : 1138, "prop" : { "x" : 2926, "y" : 1118, "width" : 40, "height" : 20 }, "textPosition" : { "x" : 2929, "y" : 1118 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2961, "y" : 1123 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2961, "y" : 1123 } } }, "connectors" : [ { "edgeId" : 94230, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2963, "y" : 1115 }, "to" : { "x" : 2998, "y" : 1099 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 94233, "reactomeId" : 10637792, "displayName" : "RHOJ GAPs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2884, "y" : 1031 }, "minX" : 2848, "maxX" : 2988, "minY" : 1020, "maxY" : 1042, "prop" : { "x" : 2848, "y" : 1020, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 2848, "y" : 1020 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94230, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2927, "y" : 1031 }, "to" : { "x" : 2980, "y" : 1032 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2984, "y" : 1032 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2984, "y" : 1032 } } } ] }, { "id" : 94232, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2948, "y" : 955 }, "minX" : 2933, "maxX" : 2998, "minY" : 942, "maxY" : 969, "prop" : { "x" : 2933, "y" : 943, "width" : 31, "height" : 24 }, "textPosition" : { "x" : 2939, "y" : 944 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2959, "y" : 948 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2959, "y" : 948 } } }, "connectors" : [ { "edgeId" : 94230, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2967, "y" : 959 }, "to" : { "x" : 2998, "y" : 969 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2975, "y" : 957 }, "b" : { "x" : 2967, "y" : 959 }, "c" : { "x" : 2972, "y" : 965 }, "type" : "ARROW", "centre" : { "x" : 2972, "y" : 965 } } } ] }, { "id" : 94235, "reactomeId" : 10637826, "displayName" : "RHOQ:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3156, "y" : 1338 }, "minX" : 2976, "maxX" : 3199, "minY" : 1321, "maxY" : 1421, "prop" : { "x" : 3120, "y" : 1327, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 3120, "y" : 1328 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3193, "y" : 1327 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3193, "y" : 1327 } } }, "connectors" : [ { "edgeId" : 94234, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3156, "y" : 1352 }, "to" : { "x" : 3158, "y" : 1421 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94240, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3117, "y" : 1342 }, "to" : { "x" : 2976, "y" : 1360 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3111, "y" : 1347 }, "b" : { "x" : 3117, "y" : 1342 }, "c" : { "x" : 3110, "y" : 1339 }, "type" : "ARROW", "centre" : { "x" : 3110, "y" : 1339 } } } ] }, { "id" : 94237, "reactomeId" : 10613969, "displayName" : "RHOQ:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3159, "y" : 1570 }, "minX" : 2980, "maxX" : 3201, "minY" : 1513, "maxY" : 1653, "prop" : { "x" : 3123, "y" : 1559, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 3123, "y" : 1560 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3195, "y" : 1559 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3195, "y" : 1559 } } }, "connectors" : [ { "edgeId" : 94234, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3158, "y" : 1556 }, "to" : { "x" : 3158, "y" : 1513 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3154, "y" : 1549 }, "b" : { "x" : 3158, "y" : 1556 }, "c" : { "x" : 3162, "y" : 1549 }, "type" : "ARROW", "centre" : { "x" : 3162, "y" : 1549 } } }, { "edgeId" : 94240, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3120, "y" : 1568 }, "to" : { "x" : 2980, "y" : 1561 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94244, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3156, "y" : 1584 }, "to" : { "x" : 3137, "y" : 1653 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94247, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94236, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3093, "y" : 1411 }, "minX" : 3073, "maxX" : 3158, "minY" : 1395, "maxY" : 1426, "prop" : { "x" : 3073, "y" : 1396, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 3077, "y" : 1400 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3109, "y" : 1401 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3109, "y" : 1401 } } }, "connectors" : [ { "edgeId" : 94234, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3117, "y" : 1414 }, "to" : { "x" : 3158, "y" : 1421 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94239, "reactomeId" : 10637849, "displayName" : "RHOQ GEFs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 3040, "y" : 1462 }, "minX" : 3002, "maxX" : 3151, "minY" : 1451, "maxY" : 1473, "prop" : { "x" : 3002, "y" : 1451, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 3016, "y" : 1445 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94234, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3084, "y" : 1463 }, "to" : { "x" : 3143, "y" : 1466 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3147, "y" : 1466 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3147, "y" : 1466 } } } ] }, { "id" : 94238, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3083, "y" : 1526 }, "minX" : 3062, "maxX" : 3158, "minY" : 1510, "maxY" : 1541, "prop" : { "x" : 3062, "y" : 1511, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 3066, "y" : 1515 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3099, "y" : 1516 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3099, "y" : 1516 } } }, "connectors" : [ { "edgeId" : 94234, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3107, "y" : 1522 }, "to" : { "x" : 3158, "y" : 1513 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3113, "y" : 1517 }, "b" : { "x" : 3107, "y" : 1522 }, "c" : { "x" : 3115, "y" : 1525 }, "type" : "ARROW", "centre" : { "x" : 3115, "y" : 1525 } } } ] }, { "id" : 94241, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2885, "y" : 1558 }, "minX" : 2863, "maxX" : 2980, "minY" : 1543, "maxY" : 1572, "prop" : { "x" : 2863, "y" : 1544, "width" : 44, "height" : 28 }, "textPosition" : { "x" : 2868, "y" : 1547 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2902, "y" : 1549 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2902, "y" : 1549 } } }, "connectors" : [ { "edgeId" : 94240, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2910, "y" : 1558 }, "to" : { "x" : 2980, "y" : 1561 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 94243, "reactomeId" : 10637828, "displayName" : "RHOQ GAPs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2870, "y" : 1469 }, "minX" : 2831, "maxX" : 2966, "minY" : 1458, "maxY" : 1480, "prop" : { "x" : 2831, "y" : 1458, "width" : 78, "height" : 22 }, "textPosition" : { "x" : 2846, "y" : 1452 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94240, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2915, "y" : 1469 }, "to" : { "x" : 2958, "y" : 1470 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2962, "y" : 1471 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2962, "y" : 1471 } } } ] }, { "id" : 94242, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2908, "y" : 1339 }, "minX" : 2890, "maxX" : 2976, "minY" : 1326, "maxY" : 1360, "prop" : { "x" : 2890, "y" : 1327, "width" : 36, "height" : 25 }, "textPosition" : { "x" : 2898, "y" : 1329 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2921, "y" : 1332 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2921, "y" : 1332 } } }, "connectors" : [ { "edgeId" : 94240, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2929, "y" : 1344 }, "to" : { "x" : 2976, "y" : 1360 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2937, "y" : 1342 }, "b" : { "x" : 2929, "y" : 1344 }, "c" : { "x" : 2934, "y" : 1350 }, "type" : "ARROW", "centre" : { "x" : 2934, "y" : 1350 } } } ] }, { "id" : 94245, "reactomeId" : 10637843, "displayName" : "RHOQ effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 3056, "y" : 1598 }, "minX" : 3007, "maxX" : 3137, "minY" : 1587, "maxY" : 1653, "prop" : { "x" : 3007, "y" : 1587, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 3024, "y" : 1581 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94244, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3072, "y" : 1615 }, "to" : { "x" : 3137, "y" : 1653 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94246, "reactomeId" : 10637845, "displayName" : "RHOQ:GTP:RHOQ effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3174, "y" : 1777 }, "minX" : 3125, "maxX" : 3230, "minY" : 1752, "maxY" : 1796, "prop" : { "x" : 3125, "y" : 1758, "width" : 99, "height" : 38 }, "textPosition" : { "x" : 3137, "y" : 1747 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3224, "y" : 1758 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3224, "y" : 1758 } } }, "connectors" : [ { "edgeId" : 94244, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94248, "reactomeId" : 10613963, "displayName" : "RHOQ:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2689, "y" : 1491 }, "minX" : 2597, "maxX" : 2731, "minY" : 1449, "maxY" : 1502, "prop" : { "x" : 2653, "y" : 1480, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 2653, "y" : 1481 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2725, "y" : 1480 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2725, "y" : 1480 } } }, "connectors" : [ { "edgeId" : 94247, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94249, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2664, "y" : 1477 }, "to" : { "x" : 2597, "y" : 1449 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94251, "reactomeId" : 10613965, "displayName" : "RHOQ:GTP:GOPC:CFTR", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2687, "y" : 1383 }, "minX" : 2646, "maxX" : 2734, "minY" : 1359, "maxY" : 1402, "prop" : { "x" : 2646, "y" : 1365, "width" : 82, "height" : 37 }, "textPosition" : { "x" : 2649, "y" : 1367 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2728, "y" : 1365 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2728, "y" : 1365 } } }, "connectors" : [ { "edgeId" : 94249, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94250, "reactomeId" : 10613957, "displayName" : "GOPC:CFTR", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2568, "y" : 1398 }, "minX" : 2530, "maxX" : 2612, "minY" : 1381, "maxY" : 1449, "prop" : { "x" : 2530, "y" : 1387, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 2530, "y" : 1388 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2606, "y" : 1387 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2606, "y" : 1387 } } }, "connectors" : [ { "edgeId" : 94249, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2574, "y" : 1412 }, "to" : { "x" : 2597, "y" : 1449 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94253, "reactomeId" : 10637856, "displayName" : "rhoh", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3176, "y" : 1886 }, "minX" : 3154, "maxX" : 3204, "minY" : 1869, "maxY" : 1932, "prop" : { "x" : 3154, "y" : 1875, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 3157, "y" : 1875 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3198, "y" : 1875 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3198, "y" : 1875 } } }, "connectors" : [ { "edgeId" : 94252, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3176, "y" : 1900 }, "to" : { "x" : 3178, "y" : 1932 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94255, "reactomeId" : 10637858, "displayName" : "RHOH:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3183, "y" : 2042 }, "minX" : 3111, "maxX" : 3225, "minY" : 1996, "maxY" : 2105, "prop" : { "x" : 3147, "y" : 2031, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 3147, "y" : 2032 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3219, "y" : 2031 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3219, "y" : 2031 } } }, "connectors" : [ { "edgeId" : 94366, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3165, "y" : 2028 }, "to" : { "x" : 3111, "y" : 1996 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94252, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94256, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3183, "y" : 2056 }, "to" : { "x" : 3185, "y" : 2105 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94254, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3117, "y" : 1938 }, "minX" : 3099, "maxX" : 3178, "minY" : 1924, "maxY" : 1951, "prop" : { "x" : 3099, "y" : 1925, "width" : 36, "height" : 26 }, "textPosition" : { "x" : 3101, "y" : 1927 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3130, "y" : 1930 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3130, "y" : 1930 } } }, "connectors" : [ { "edgeId" : 94252, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3138, "y" : 1936 }, "to" : { "x" : 3178, "y" : 1932 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94257, "reactomeId" : 10637888, "displayName" : "RHOH effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 3092, "y" : 2097 }, "minX" : 3043, "maxX" : 3185, "minY" : 2086, "maxY" : 2108, "prop" : { "x" : 3043, "y" : 2086, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 3060, "y" : 2080 }, "connectors" : [ { "edgeId" : 94256, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3147, "y" : 2101 }, "to" : { "x" : 3185, "y" : 2105 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94258, "reactomeId" : 10637890, "displayName" : "RHOH:GTP:RHOH effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3185, "y" : 2213 }, "minX" : 3134, "maxX" : 3242, "minY" : 2190, "maxY" : 2231, "prop" : { "x" : 3134, "y" : 2196, "width" : 102, "height" : 35 }, "textPosition" : { "x" : 3147, "y" : 2182 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3236, "y" : 2196 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3236, "y" : 2196 } } }, "connectors" : [ { "edgeId" : 94256, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94261, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1313, "y" : 2371 }, "minX" : 1290, "maxX" : 1335, "minY" : 2355, "maxY" : 2410, "prop" : { "x" : 1293, "y" : 2356, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1297, "y" : 2360 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1329, "y" : 2361 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1329, "y" : 2361 } } }, "connectors" : [ { "edgeId" : 94259, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1304, "y" : 2389 }, "to" : { "x" : 1290, "y" : 2410 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94260, "reactomeId" : 10637922, "displayName" : "RHOU:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1411, "y" : 2412 }, "minX" : 1244, "maxX" : 1453, "minY" : 2395, "maxY" : 2445, "prop" : { "x" : 1375, "y" : 2401, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 1387, "y" : 2388 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1447, "y" : 2401 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1447, "y" : 2401 } } }, "connectors" : [ { "edgeId" : 94259, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1372, "y" : 2411 }, "to" : { "x" : 1290, "y" : 2410 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94259, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1372, "y" : 2419 }, "to" : { "x" : 1258, "y" : 2445 } }, { "from" : { "x" : 1258, "y" : 2445 }, "to" : { "x" : 1250, "y" : 2424 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1248, "y" : 2420 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1248, "y" : 2420 } } } ] }, { "id" : 94263, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1161, "y" : 2356 }, "minX" : 1141, "maxX" : 1197, "minY" : 2340, "maxY" : 2410, "prop" : { "x" : 1141, "y" : 2341, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1144, "y" : 2345 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1177, "y" : 2346 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1177, "y" : 2346 } } }, "connectors" : [ { "edgeId" : 94259, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1171, "y" : 2374 }, "to" : { "x" : 1197, "y" : 2410 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1178, "y" : 2377 }, "b" : { "x" : 1171, "y" : 2374 }, "c" : { "x" : 1172, "y" : 2382 }, "type" : "ARROW", "centre" : { "x" : 1172, "y" : 2382 } } } ] }, { "id" : 94262, "reactomeId" : 10637898, "displayName" : "RHOU:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1112, "y" : 2411 }, "minX" : 1063, "maxX" : 1197, "minY" : 2347, "maxY" : 2422, "prop" : { "x" : 1077, "y" : 2400, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 1077, "y" : 2401 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1148, "y" : 2400 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1148, "y" : 2400 } } }, "connectors" : [ { "edgeId" : 94259, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1151, "y" : 2410 }, "to" : { "x" : 1197, "y" : 2410 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1158, "y" : 2406 }, "b" : { "x" : 1151, "y" : 2410 }, "c" : { "x" : 1158, "y" : 2414 }, "type" : "ARROW", "centre" : { "x" : 1158, "y" : 2414 } } }, { "edgeId" : 94264, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1103, "y" : 2397 }, "to" : { "x" : 1063, "y" : 2347 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94265, "reactomeId" : 10637916, "displayName" : "RHOU effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1047, "y" : 2301 }, "minX" : 999, "maxX" : 1096, "minY" : 2290, "maxY" : 2347, "prop" : { "x" : 999, "y" : 2290, "width" : 97, "height" : 22 }, "textPosition" : { "x" : 1015, "y" : 2284 }, "connectors" : [ { "edgeId" : 94264, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1050, "y" : 2318 }, "to" : { "x" : 1063, "y" : 2347 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94266, "reactomeId" : 10637918, "displayName" : "RHOU:GTP:RHOU effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 997, "y" : 2419 }, "minX" : 946, "maxX" : 1054, "minY" : 2395, "maxY" : 2437, "prop" : { "x" : 946, "y" : 2401, "width" : 102, "height" : 36 }, "textPosition" : { "x" : 959, "y" : 2388 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1048, "y" : 2401 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1048, "y" : 2401 } } }, "connectors" : [ { "edgeId" : 94264, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94269, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2614, "y" : 119 }, "minX" : 2594, "maxX" : 2645, "minY" : 68, "maxY" : 134, "prop" : { "x" : 2594, "y" : 104, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 2598, "y" : 108 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2630, "y" : 109 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2630, "y" : 109 } } }, "connectors" : [ { "edgeId" : 94267, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2623, "y" : 101 }, "to" : { "x" : 2645, "y" : 68 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94268, "reactomeId" : 10637661, "displayName" : "RAC2:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2570, "y" : 59 }, "minX" : 2535, "maxX" : 2645, "minY" : 42, "maxY" : 216, "prop" : { "x" : 2535, "y" : 48, "width" : 70, "height" : 22 }, "textPosition" : { "x" : 2535, "y" : 49 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2605, "y" : 48 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2605, "y" : 48 } } }, "connectors" : [ { "edgeId" : 94267, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2608, "y" : 63 }, "to" : { "x" : 2645, "y" : 68 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94273, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2571, "y" : 73 }, "to" : { "x" : 2588, "y" : 216 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2576, "y" : 79 }, "b" : { "x" : 2571, "y" : 73 }, "c" : { "x" : 2568, "y" : 80 }, "type" : "ARROW", "centre" : { "x" : 2568, "y" : 80 } } }, { "edgeId" : 94277, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2564, "y" : 73 }, "to" : { "x" : 2543, "y" : 113 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94271, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2736, "y" : 118 }, "minX" : 2708, "maxX" : 2758, "minY" : 69, "maxY" : 133, "prop" : { "x" : 2715, "y" : 103, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 2719, "y" : 107 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2752, "y" : 108 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2752, "y" : 108 } } }, "connectors" : [ { "edgeId" : 94267, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2727, "y" : 100 }, "to" : { "x" : 2708, "y" : 69 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2720, "y" : 96 }, "b" : { "x" : 2727, "y" : 100 }, "c" : { "x" : 2727, "y" : 92 }, "type" : "ARROW", "centre" : { "x" : 2727, "y" : 92 } } } ] }, { "id" : 94270, "reactomeId" : 10567504, "displayName" : "RAC2:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2773, "y" : 67 }, "minX" : 2708, "maxX" : 2922, "minY" : 50, "maxY" : 202, "prop" : { "x" : 2739, "y" : 56, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 2739, "y" : 57 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2808, "y" : 56 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2808, "y" : 56 } } }, "connectors" : [ { "edgeId" : 94390, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94392, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94267, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2736, "y" : 68 }, "to" : { "x" : 2708, "y" : 69 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2729, "y" : 72 }, "b" : { "x" : 2736, "y" : 68 }, "c" : { "x" : 2729, "y" : 64 }, "type" : "ARROW", "centre" : { "x" : 2729, "y" : 64 } } }, { "edgeId" : 94273, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2773, "y" : 81 }, "to" : { "x" : 2773, "y" : 202 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94280, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2799, "y" : 81 }, "to" : { "x" : 2922, "y" : 128 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94283, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94272, "reactomeId" : 10637692, "displayName" : "RAC2 GEFs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2677, "y" : 173 }, "minX" : 2641, "maxX" : 2714, "minY" : 79, "maxY" : 184, "prop" : { "x" : 2641, "y" : 162, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 2655, "y" : 156 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94267, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2677, "y" : 156 }, "to" : { "x" : 2677, "y" : 87 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2677, "y" : 83 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2677, "y" : 83 } } } ] }, { "id" : 94275, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2552, "y" : 256 }, "minX" : 2537, "maxX" : 2588, "minY" : 216, "maxY" : 268, "prop" : { "x" : 2537, "y" : 244, "width" : 31, "height" : 24 }, "textPosition" : { "x" : 2543, "y" : 245 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2563, "y" : 249 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2563, "y" : 249 } } }, "connectors" : [ { "edgeId" : 94273, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2562, "y" : 241 }, "to" : { "x" : 2588, "y" : 216 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2564, "y" : 233 }, "b" : { "x" : 2562, "y" : 241 }, "c" : { "x" : 2570, "y" : 239 }, "type" : "ARROW", "centre" : { "x" : 2570, "y" : 239 } } } ] }, { "id" : 94274, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2770, "y" : 262 }, "minX" : 2751, "maxX" : 2791, "minY" : 202, "maxY" : 276, "prop" : { "x" : 2751, "y" : 249, "width" : 39, "height" : 27 }, "textPosition" : { "x" : 2753, "y" : 252 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2785, "y" : 254 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2785, "y" : 254 } } }, "connectors" : [ { "edgeId" : 94273, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2770, "y" : 246 }, "to" : { "x" : 2773, "y" : 202 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 94276, "reactomeId" : 10637687, "displayName" : "RAC2 GAPs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2685, "y" : 307 }, "minX" : 2648, "maxX" : 2723, "minY" : 229, "maxY" : 318, "prop" : { "x" : 2648, "y" : 296, "width" : 75, "height" : 22 }, "textPosition" : { "x" : 2663, "y" : 290 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94273, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2685, "y" : 290 }, "to" : { "x" : 2686, "y" : 237 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2686, "y" : 233 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2686, "y" : 233 } } } ] }, { "id" : 94279, "reactomeId" : 10637665, "displayName" : "ARHGDIA:RAC2:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2527, "y" : 197 }, "minX" : 2489, "maxX" : 2571, "minY" : 173, "maxY" : 216, "prop" : { "x" : 2489, "y" : 179, "width" : 76, "height" : 37 }, "textPosition" : { "x" : 2492, "y" : 181 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2565, "y" : 179 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2565, "y" : 179 } } }, "connectors" : [ { "edgeId" : 94277, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94278, "reactomeId" : 10573592, "displayName" : "arhgdia", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2476, "y" : 120 }, "minX" : 2445, "maxX" : 2543, "minY" : 103, "maxY" : 131, "prop" : { "x" : 2445, "y" : 109, "width" : 63, "height" : 22 }, "textPosition" : { "x" : 2448, "y" : 109 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2508, "y" : 109 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2508, "y" : 109 } } }, "connectors" : [ { "edgeId" : 94277, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2511, "y" : 116 }, "to" : { "x" : 2543, "y" : 113 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94281, "reactomeId" : 10637681, "displayName" : "RAC2 plasma membrane effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2895, "y" : 181 }, "minX" : 2847, "maxX" : 2943, "minY" : 128, "maxY" : 203, "prop" : { "x" : 2847, "y" : 159, "width" : 96, "height" : 44 }, "textPosition" : { "x" : 2848, "y" : 157 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94280, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2906, "y" : 153 }, "to" : { "x" : 2922, "y" : 128 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94282, "reactomeId" : 10637683, "displayName" : "RAC2:GTP:RAC2 cytosolic effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3026, "y" : 67 }, "minX" : 2971, "maxX" : 3088, "minY" : 43, "maxY" : 85, "prop" : { "x" : 2971, "y" : 49, "width" : 111, "height" : 36 }, "textPosition" : { "x" : 2972, "y" : 36 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3082, "y" : 49 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3082, "y" : 49 } } }, "connectors" : [ { "edgeId" : 94280, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94284, "reactomeId" : 10615795, "displayName" : "RAC2:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2759, "y" : 431 }, "minX" : 2725, "maxX" : 2846, "minY" : 414, "maxY" : 457, "prop" : { "x" : 2725, "y" : 420, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 2725, "y" : 421 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2794, "y" : 420 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2794, "y" : 420 } } }, "connectors" : [ { "edgeId" : 94283, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94285, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2797, "y" : 441 }, "to" : { "x" : 2846, "y" : 457 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94287, "reactomeId" : 10615797, "displayName" : "NOX2 complex:RAC2:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2908, "y" : 521 }, "minX" : 2843, "maxX" : 2979, "minY" : 497, "maxY" : 539, "prop" : { "x" : 2843, "y" : 503, "width" : 130, "height" : 36 }, "textPosition" : { "x" : 2858, "y" : 504 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2973, "y" : 503 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2973, "y" : 503 } } }, "connectors" : [ { "edgeId" : 94285, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94286, "reactomeId" : 10594175, "displayName" : "NOX2 complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2871, "y" : 406 }, "minX" : 2825, "maxX" : 2924, "minY" : 377, "maxY" : 457, "prop" : { "x" : 2825, "y" : 383, "width" : 93, "height" : 47 }, "textPosition" : { "x" : 2842, "y" : 389 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2918, "y" : 383 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2918, "y" : 383 } } }, "connectors" : [ { "edgeId" : 94285, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2859, "y" : 436 }, "to" : { "x" : 2846, "y" : 457 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94289, "reactomeId" : 10637701, "displayName" : "RHOG:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 53, "y" : 387 }, "minX" : 17, "maxX" : 231, "minY" : 339, "maxY" : 432, "prop" : { "x" : 17, "y" : 376, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 17, "y" : 377 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 90, "y" : 376 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 90, "y" : 376 } } }, "connectors" : [ { "edgeId" : 94288, "type" : "INPUT", "segments" : [ { "from" : { "x" : 51, "y" : 401 }, "to" : { "x" : 48, "y" : 432 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94294, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 93, "y" : 389 }, "to" : { "x" : 231, "y" : 400 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 100, "y" : 386 }, "b" : { "x" : 93, "y" : 389 }, "c" : { "x" : 100, "y" : 394 }, "type" : "ARROW", "centre" : { "x" : 100, "y" : 394 } } }, { "edgeId" : 94297, "type" : "INPUT", "segments" : [ { "from" : { "x" : 61, "y" : 373 }, "to" : { "x" : 91, "y" : 339 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94291, "reactomeId" : 10567510, "displayName" : "RHOG:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 45, "y" : 564 }, "minX" : 9, "maxX" : 215, "minY" : 518, "maxY" : 612, "prop" : { "x" : 9, "y" : 553, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 9, "y" : 554 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 81, "y" : 553 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 81, "y" : 553 } } }, "connectors" : [ { "edgeId" : 94288, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 46, "y" : 550 }, "to" : { "x" : 51, "y" : 518 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 43, "y" : 543 }, "b" : { "x" : 46, "y" : 550 }, "c" : { "x" : 51, "y" : 544 }, "type" : "ARROW", "centre" : { "x" : 51, "y" : 544 } } }, { "edgeId" : 94294, "type" : "INPUT", "segments" : [ { "from" : { "x" : 84, "y" : 562 }, "to" : { "x" : 215, "y" : 556 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94300, "type" : "INPUT", "segments" : [ { "from" : { "x" : 58, "y" : 578 }, "to" : { "x" : 105, "y" : 612 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94303, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94290, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 121, "y" : 425 }, "minX" : 48, "maxX" : 143, "minY" : 409, "maxY" : 440, "prop" : { "x" : 101, "y" : 410, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 105, "y" : 414 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 137, "y" : 415 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 137, "y" : 415 } } }, "connectors" : [ { "edgeId" : 94288, "type" : "INPUT", "segments" : [ { "from" : { "x" : 98, "y" : 426 }, "to" : { "x" : 48, "y" : 432 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94293, "reactomeId" : 10637703, "displayName" : "RHOG GEFs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 157, "y" : 474 }, "minX" : 57, "maxX" : 195, "minY" : 463, "maxY" : 485, "prop" : { "x" : 119, "y" : 463, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 133, "y" : 457 }, "connectors" : [ { "edgeId" : 94288, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 113, "y" : 476 }, "to" : { "x" : 65, "y" : 480 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 61, "y" : 480 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 61, "y" : 480 } } } ] }, { "id" : 94292, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 117, "y" : 529 }, "minX" : 51, "maxX" : 139, "minY" : 513, "maxY" : 544, "prop" : { "x" : 96, "y" : 514, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 100, "y" : 518 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 133, "y" : 519 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 133, "y" : 519 } } }, "connectors" : [ { "edgeId" : 94288, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 93, "y" : 525 }, "to" : { "x" : 51, "y" : 518 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 86, "y" : 528 }, "b" : { "x" : 93, "y" : 525 }, "c" : { "x" : 87, "y" : 520 }, "type" : "ARROW", "centre" : { "x" : 87, "y" : 520 } } } ] }, { "id" : 94295, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 277, "y" : 594 }, "minX" : 215, "maxX" : 300, "minY" : 556, "maxY" : 609, "prop" : { "x" : 256, "y" : 579, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 260, "y" : 583 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 294, "y" : 584 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 294, "y" : 584 } } }, "connectors" : [ { "edgeId" : 94294, "type" : "INPUT", "segments" : [ { "from" : { "x" : 253, "y" : 580 }, "to" : { "x" : 215, "y" : 556 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 94296, "reactomeId" : 10637708, "displayName" : "RHOG GAPs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 320, "y" : 466 }, "minX" : 226, "maxX" : 359, "minY" : 455, "maxY" : 478, "prop" : { "x" : 281, "y" : 455, "width" : 78, "height" : 22 }, "textPosition" : { "x" : 296, "y" : 449 }, "connectors" : [ { "edgeId" : 94294, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 275, "y" : 469 }, "to" : { "x" : 234, "y" : 473 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 230, "y" : 474 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 230, "y" : 474 } } } ] }, { "id" : 94299, "reactomeId" : 10637733, "displayName" : "RHOG GDIs:RHOG:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 188, "y" : 338 }, "minX" : 144, "maxX" : 239, "minY" : 314, "maxY" : 357, "prop" : { "x" : 144, "y" : 320, "width" : 89, "height" : 37 }, "textPosition" : { "x" : 149, "y" : 322 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 233, "y" : 320 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 233, "y" : 320 } } }, "connectors" : [ { "edgeId" : 94297, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94298, "reactomeId" : 10637314, "displayName" : "ARHGDIA,ARHGDIB", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 106, "y" : 279 }, "minX" : 69, "maxX" : 144, "minY" : 256, "maxY" : 339, "prop" : { "x" : 69, "y" : 256, "width" : 75, "height" : 47 }, "textPosition" : { "x" : 73, "y" : 262 }, "connectors" : [ { "edgeId" : 94297, "type" : "INPUT", "segments" : [ { "from" : { "x" : 100, "y" : 309 }, "to" : { "x" : 91, "y" : 339 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94301, "reactomeId" : 10637721, "displayName" : "RHOG plasma membrane effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 196, "y" : 649 }, "minX" : 105, "maxX" : 259, "minY" : 612, "maxY" : 667, "prop" : { "x" : 133, "y" : 631, "width" : 126, "height" : 36 }, "textPosition" : { "x" : 148, "y" : 625 }, "connectors" : [ { "edgeId" : 94300, "type" : "INPUT", "segments" : [ { "from" : { "x" : 151, "y" : 625 }, "to" : { "x" : 105, "y" : 612 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94302, "reactomeId" : 10637723, "displayName" : "RHOG:GTP:RHOG plasma membrane effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 61, "y" : 722 }, "minX" : 0, "maxX" : 128, "minY" : 691, "maxY" : 747, "prop" : { "x" : 0, "y" : 697, "width" : 122, "height" : 50 }, "textPosition" : { "x" : 4, "y" : 684 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 122, "y" : 697 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 122, "y" : 697 } } }, "connectors" : [ { "edgeId" : 94300, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94304, "reactomeId" : 10637727, "displayName" : "RHOG:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 621, "y" : 498 }, "minX" : 585, "maxX" : 709, "minY" : 481, "maxY" : 509, "prop" : { "x" : 585, "y" : 487, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 585, "y" : 488 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 657, "y" : 487 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 657, "y" : 487 } } }, "connectors" : [ { "edgeId" : 94303, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94305, "type" : "INPUT", "segments" : [ { "from" : { "x" : 660, "y" : 500 }, "to" : { "x" : 709, "y" : 505 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94307, "reactomeId" : 10637757, "displayName" : "RHOG:GTP:RHOG endoplasmic reticulum effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 662, "y" : 398 }, "minX" : 569, "maxX" : 762, "minY" : 373, "maxY" : 418, "prop" : { "x" : 569, "y" : 379, "width" : 187, "height" : 39 }, "textPosition" : { "x" : 586, "y" : 369 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 756, "y" : 379 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 756, "y" : 379 } } }, "connectors" : [ { "edgeId" : 94305, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94306, "reactomeId" : 10637755, "displayName" : "RHOG endoplasmic reticulum effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 640, "y" : 556 }, "minX" : 578, "maxX" : 709, "minY" : 505, "maxY" : 574, "prop" : { "x" : 578, "y" : 538, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 595, "y" : 525 }, "connectors" : [ { "edgeId" : 94305, "type" : "INPUT", "segments" : [ { "from" : { "x" : 664, "y" : 532 }, "to" : { "x" : 709, "y" : 505 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94309, "reactomeId" : 10637929, "displayName" : "rhobtb1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 389, "y" : 1939 }, "minX" : 355, "maxX" : 457, "minY" : 1922, "maxY" : 1950, "prop" : { "x" : 355, "y" : 1928, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 360, "y" : 1928 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 424, "y" : 1928 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 424, "y" : 1928 } } }, "connectors" : [ { "edgeId" : 94308, "type" : "INPUT", "segments" : [ { "from" : { "x" : 427, "y" : 1941 }, "to" : { "x" : 457, "y" : 1943 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94311, "reactomeId" : 10637931, "displayName" : "RHOBTB1:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 590, "y" : 1945 }, "minX" : 544, "maxX" : 664, "minY" : 1928, "maxY" : 1956, "prop" : { "x" : 544, "y" : 1934, "width" : 93, "height" : 22 }, "textPosition" : { "x" : 544, "y" : 1935 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 637, "y" : 1934 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 637, "y" : 1934 } } }, "connectors" : [ { "edgeId" : 94308, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94312, "type" : "INPUT", "segments" : [ { "from" : { "x" : 640, "y" : 1943 }, "to" : { "x" : 664, "y" : 1942 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94310, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 446, "y" : 1883 }, "minX" : 426, "maxX" : 467, "minY" : 1870, "maxY" : 1943, "prop" : { "x" : 426, "y" : 1871, "width" : 40, "height" : 25 }, "textPosition" : { "x" : 430, "y" : 1873 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 461, "y" : 1876 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 461, "y" : 1876 } } }, "connectors" : [ { "edgeId" : 94308, "type" : "INPUT", "segments" : [ { "from" : { "x" : 448, "y" : 1899 }, "to" : { "x" : 457, "y" : 1943 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94313, "reactomeId" : 10637949, "displayName" : "RHOBTB1 interacting proteins", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 645, "y" : 1860 }, "minX" : 585, "maxX" : 706, "minY" : 1846, "maxY" : 1942, "prop" : { "x" : 585, "y" : 1846, "width" : 121, "height" : 29 }, "textPosition" : { "x" : 605, "y" : 1836 }, "connectors" : [ { "edgeId" : 94312, "type" : "INPUT", "segments" : [ { "from" : { "x" : 648, "y" : 1881 }, "to" : { "x" : 664, "y" : 1942 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94314, "reactomeId" : 10637951, "displayName" : "RHOBTB1:GTP:RHOBTB1 interacting proteins", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 842, "y" : 1945 }, "minX" : 781, "maxX" : 909, "minY" : 1915, "maxY" : 1969, "prop" : { "x" : 781, "y" : 1921, "width" : 122, "height" : 48 }, "textPosition" : { "x" : 793, "y" : 1906 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 903, "y" : 1921 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 903, "y" : 1921 } } }, "connectors" : [ { "edgeId" : 94312, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94317, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 562, "y" : 2335 }, "minX" : 542, "maxX" : 607, "minY" : 2319, "maxY" : 2396, "prop" : { "x" : 542, "y" : 2320, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 546, "y" : 2324 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 578, "y" : 2325 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 578, "y" : 2325 } } }, "connectors" : [ { "edgeId" : 94315, "type" : "INPUT", "segments" : [ { "from" : { "x" : 573, "y" : 2353 }, "to" : { "x" : 607, "y" : 2396 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94316, "reactomeId" : 10637967, "displayName" : "RHOV:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 517, "y" : 2413 }, "minX" : 481, "maxX" : 607, "minY" : 2396, "maxY" : 2424, "prop" : { "x" : 481, "y" : 2402, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 481, "y" : 2403 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 553, "y" : 2402 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 553, "y" : 2402 } } }, "connectors" : [ { "edgeId" : 94315, "type" : "INPUT", "segments" : [ { "from" : { "x" : 556, "y" : 2406 }, "to" : { "x" : 607, "y" : 2396 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94319, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 718, "y" : 2347 }, "minX" : 678, "maxX" : 740, "minY" : 2331, "maxY" : 2397, "prop" : { "x" : 697, "y" : 2332, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 701, "y" : 2336 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 734, "y" : 2337 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 734, "y" : 2337 } } }, "connectors" : [ { "edgeId" : 94315, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 706, "y" : 2365 }, "to" : { "x" : 678, "y" : 2397 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 704, "y" : 2373 }, "b" : { "x" : 706, "y" : 2365 }, "c" : { "x" : 698, "y" : 2368 }, "type" : "ARROW", "centre" : { "x" : 698, "y" : 2368 } } } ] }, { "id" : 94318, "reactomeId" : 10637959, "displayName" : "RHOV:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 750, "y" : 2415 }, "minX" : 678, "maxX" : 801, "minY" : 2364, "maxY" : 2426, "prop" : { "x" : 715, "y" : 2404, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 715, "y" : 2405 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 786, "y" : 2404 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 786, "y" : 2404 } } }, "connectors" : [ { "edgeId" : 94315, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 712, "y" : 2406 }, "to" : { "x" : 678, "y" : 2397 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 704, "y" : 2408 }, "b" : { "x" : 712, "y" : 2406 }, "c" : { "x" : 706, "y" : 2400 }, "type" : "ARROW", "centre" : { "x" : 706, "y" : 2400 } } }, { "edgeId" : 94320, "type" : "INPUT", "segments" : [ { "from" : { "x" : 761, "y" : 2401 }, "to" : { "x" : 801, "y" : 2364 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94321, "reactomeId" : 10637961, "displayName" : "RHOV effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 816, "y" : 2290 }, "minX" : 768, "maxX" : 865, "minY" : 2279, "maxY" : 2364, "prop" : { "x" : 768, "y" : 2279, "width" : 97, "height" : 22 }, "textPosition" : { "x" : 784, "y" : 2273 }, "connectors" : [ { "edgeId" : 94320, "type" : "INPUT", "segments" : [ { "from" : { "x" : 813, "y" : 2307 }, "to" : { "x" : 801, "y" : 2364 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94322, "reactomeId" : 10637963, "displayName" : "RHOV:GTP:RHOV effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 876, "y" : 2412 }, "minX" : 828, "maxX" : 930, "minY" : 2388, "maxY" : 2431, "prop" : { "x" : 828, "y" : 2394, "width" : 96, "height" : 37 }, "textPosition" : { "x" : 839, "y" : 2382 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 924, "y" : 2394 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 924, "y" : 2394 } } }, "connectors" : [ { "edgeId" : 94320, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94325, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3113, "y" : 271 }, "minX" : 3093, "maxX" : 3183, "minY" : 255, "maxY" : 286, "prop" : { "x" : 3093, "y" : 256, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 3097, "y" : 260 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3129, "y" : 261 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3129, "y" : 261 } } }, "connectors" : [ { "edgeId" : 94323, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3137, "y" : 275 }, "to" : { "x" : 3183, "y" : 285 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94324, "reactomeId" : 10637977, "displayName" : "RAC3:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3181, "y" : 227 }, "minX" : 3022, "maxX" : 3222, "minY" : 177, "maxY" : 285, "prop" : { "x" : 3146, "y" : 216, "width" : 70, "height" : 23 }, "textPosition" : { "x" : 3146, "y" : 218 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3216, "y" : 216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3216, "y" : 216 } } }, "connectors" : [ { "edgeId" : 94323, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3181, "y" : 242 }, "to" : { "x" : 3183, "y" : 285 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94329, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3143, "y" : 233 }, "to" : { "x" : 3022, "y" : 256 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3137, "y" : 238 }, "b" : { "x" : 3143, "y" : 233 }, "c" : { "x" : 3135, "y" : 230 }, "type" : "ARROW", "centre" : { "x" : 3135, "y" : 230 } } }, { "edgeId" : 94333, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3168, "y" : 213 }, "to" : { "x" : 3126, "y" : 177 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94327, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3120, "y" : 442 }, "minX" : 3099, "maxX" : 3183, "minY" : 399, "maxY" : 457, "prop" : { "x" : 3099, "y" : 427, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 3103, "y" : 431 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3136, "y" : 432 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3136, "y" : 432 } } }, "connectors" : [ { "edgeId" : 94323, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3144, "y" : 427 }, "to" : { "x" : 3183, "y" : 399 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3147, "y" : 420 }, "b" : { "x" : 3144, "y" : 427 }, "c" : { "x" : 3152, "y" : 426 }, "type" : "ARROW", "centre" : { "x" : 3152, "y" : 426 } } } ] }, { "id" : 94326, "reactomeId" : 10637979, "displayName" : "RAC3:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3182, "y" : 501 }, "minX" : 3027, "maxX" : 3223, "minY" : 399, "maxY" : 519, "prop" : { "x" : 3148, "y" : 490, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 3148, "y" : 491 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3217, "y" : 490 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3217, "y" : 490 } } }, "connectors" : [ { "edgeId" : 94336, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3145, "y" : 510 }, "to" : { "x" : 3119, "y" : 519 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94397, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94323, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3182, "y" : 487 }, "to" : { "x" : 3183, "y" : 399 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3178, "y" : 480 }, "b" : { "x" : 3182, "y" : 487 }, "c" : { "x" : 3186, "y" : 480 }, "type" : "ARROW", "centre" : { "x" : 3186, "y" : 480 } } }, { "edgeId" : 94329, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3145, "y" : 495 }, "to" : { "x" : 3027, "y" : 477 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94328, "reactomeId" : 10637981, "displayName" : "RAC3 GEFs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 3103, "y" : 343 }, "minX" : 3067, "maxX" : 3177, "minY" : 332, "maxY" : 354, "prop" : { "x" : 3067, "y" : 332, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 3081, "y" : 326 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94323, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3146, "y" : 342 }, "to" : { "x" : 3169, "y" : 341 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3173, "y" : 341 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3173, "y" : 341 } } } ] }, { "id" : 94331, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2969, "y" : 254 }, "minX" : 2951, "maxX" : 3022, "minY" : 239, "maxY" : 268, "prop" : { "x" : 2951, "y" : 240, "width" : 36, "height" : 28 }, "textPosition" : { "x" : 2959, "y" : 243 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2982, "y" : 245 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2982, "y" : 245 } } }, "connectors" : [ { "edgeId" : 94329, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2990, "y" : 254 }, "to" : { "x" : 3022, "y" : 256 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2997, "y" : 250 }, "b" : { "x" : 2990, "y" : 254 }, "c" : { "x" : 2997, "y" : 258 }, "type" : "ARROW", "centre" : { "x" : 2997, "y" : 258 } } } ] }, { "id" : 94330, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3010, "y" : 514 }, "minX" : 2990, "maxX" : 3031, "minY" : 477, "maxY" : 527, "prop" : { "x" : 2990, "y" : 502, "width" : 40, "height" : 25 }, "textPosition" : { "x" : 2993, "y" : 504 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3025, "y" : 507 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3025, "y" : 507 } } }, "connectors" : [ { "edgeId" : 94329, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3015, "y" : 499 }, "to" : { "x" : 3027, "y" : 477 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 94332, "reactomeId" : 10637986, "displayName" : "RAC3 GAPs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2941, "y" : 350 }, "minX" : 2904, "maxX" : 3014, "minY" : 339, "maxY" : 361, "prop" : { "x" : 2904, "y" : 339, "width" : 75, "height" : 22 }, "textPosition" : { "x" : 2919, "y" : 333 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94329, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2985, "y" : 349 }, "to" : { "x" : 3006, "y" : 349 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3010, "y" : 349 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3010, "y" : 349 } } } ] }, { "id" : 94335, "reactomeId" : 10637995, "displayName" : "RAC3:GDP:RAC3 GDIs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3017, "y" : 189 }, "minX" : 2977, "maxX" : 3064, "minY" : 165, "maxY" : 207, "prop" : { "x" : 2977, "y" : 171, "width" : 81, "height" : 36 }, "textPosition" : { "x" : 2980, "y" : 172 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3058, "y" : 171 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3058, "y" : 171 } } }, "connectors" : [ { "edgeId" : 94333, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94334, "reactomeId" : 10637991, "displayName" : "RAC3 GDIs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 3103, "y" : 124 }, "minX" : 3067, "maxX" : 3139, "minY" : 113, "maxY" : 177, "prop" : { "x" : 3067, "y" : 113, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 3067, "y" : 113 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94333, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3107, "y" : 141 }, "to" : { "x" : 3126, "y" : 177 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94337, "reactomeId" : 10638007, "displayName" : "RAC3 effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 3052, "y" : 570 }, "minX" : 3023, "maxX" : 3119, "minY" : 519, "maxY" : 586, "prop" : { "x" : 3023, "y" : 554, "width" : 58, "height" : 32 }, "textPosition" : { "x" : 3023, "y" : 546 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94336, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3073, "y" : 548 }, "to" : { "x" : 3119, "y" : 519 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94338, "reactomeId" : 10638009, "displayName" : "RAC3:GTP:RAC3 effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3193, "y" : 599 }, "minX" : 3146, "maxX" : 3247, "minY" : 576, "maxY" : 617, "prop" : { "x" : 3146, "y" : 582, "width" : 95, "height" : 35 }, "textPosition" : { "x" : 3157, "y" : 568 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3241, "y" : 582 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3241, "y" : 582 } } }, "connectors" : [ { "edgeId" : 94336, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94340, "reactomeId" : 10615600, "displayName" : "RHOB:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2271, "y" : 618 }, "minX" : 2234, "maxX" : 2314, "minY" : 602, "maxY" : 684, "prop" : { "x" : 2234, "y" : 608, "width" : 74, "height" : 20 }, "textPosition" : { "x" : 2236, "y" : 607 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2308, "y" : 608 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2308, "y" : 608 } } }, "connectors" : [ { "edgeId" : 94339, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94341, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2270, "y" : 631 }, "to" : { "x" : 2268, "y" : 684 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94343, "reactomeId" : 10640317, "displayName" : "RHOB:GTP:RHOB endosome effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2431, "y" : 682 }, "minX" : 2389, "maxX" : 2479, "minY" : 645, "maxY" : 714, "prop" : { "x" : 2389, "y" : 651, "width" : 84, "height" : 63 }, "textPosition" : { "x" : 2392, "y" : 651 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2473, "y" : 651 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2473, "y" : 651 } } }, "connectors" : [ { "edgeId" : 94341, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94342, "reactomeId" : 10615631, "displayName" : "rhpn2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2207, "y" : 748 }, "minX" : 2146, "maxX" : 2275, "minY" : 684, "maxY" : 767, "prop" : { "x" : 2146, "y" : 729, "width" : 123, "height" : 38 }, "textPosition" : { "x" : 2185, "y" : 737 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2269, "y" : 729 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2269, "y" : 729 } } }, "connectors" : [ { "edgeId" : 94341, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2225, "y" : 723 }, "to" : { "x" : 2268, "y" : 684 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94345, "reactomeId" : 10640326, "displayName" : "RAC1:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 980, "y" : 421 }, "minX" : 896, "maxX" : 1020, "minY" : 404, "maxY" : 432, "prop" : { "x" : 946, "y" : 410, "width" : 68, "height" : 22 }, "textPosition" : { "x" : 946, "y" : 411 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1014, "y" : 410 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1014, "y" : 410 } } }, "connectors" : [ { "edgeId" : 94344, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94346, "type" : "INPUT", "segments" : [ { "from" : { "x" : 943, "y" : 419 }, "to" : { "x" : 896, "y" : 417 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94347, "reactomeId" : 10640330, "displayName" : "RAC1 endoplasmic reticulum effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 969, "y" : 365 }, "minX" : 896, "maxX" : 1030, "minY" : 347, "maxY" : 417, "prop" : { "x" : 908, "y" : 347, "width" : 122, "height" : 36 }, "textPosition" : { "x" : 923, "y" : 334 }, "connectors" : [ { "edgeId" : 94346, "type" : "INPUT", "segments" : [ { "from" : { "x" : 943, "y" : 389 }, "to" : { "x" : 896, "y" : 417 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94348, "reactomeId" : 10640332, "displayName" : "RAC1:GTP:RAC1 endoplasmic reticulum effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 993, "y" : 473 }, "minX" : 935, "maxX" : 1057, "minY" : 442, "maxY" : 498, "prop" : { "x" : 935, "y" : 448, "width" : 116, "height" : 50 }, "textPosition" : { "x" : 939, "y" : 435 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1051, "y" : 448 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1051, "y" : 448 } } }, "connectors" : [ { "edgeId" : 94346, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94350, "reactomeId" : 10640351, "displayName" : "CDC42:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 967, "y" : 527 }, "minX" : 844, "maxX" : 1014, "minY" : 458, "maxY" : 538, "prop" : { "x" : 927, "y" : 516, "width" : 81, "height" : 22 }, "textPosition" : { "x" : 929, "y" : 517 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1008, "y" : 516 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1008, "y" : 516 } } }, "connectors" : [ { "edgeId" : 94349, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94351, "type" : "INPUT", "segments" : [ { "from" : { "x" : 947, "y" : 513 }, "to" : { "x" : 844, "y" : 458 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94353, "reactomeId" : 10640357, "displayName" : "CDC42:GTP:CDC42 endoplasmic reticulum effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 957, "y" : 612 }, "minX" : 894, "maxX" : 1027, "minY" : 581, "maxY" : 637, "prop" : { "x" : 894, "y" : 587, "width" : 127, "height" : 50 }, "textPosition" : { "x" : 894, "y" : 588 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1021, "y" : 587 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1021, "y" : 587 } } }, "connectors" : [ { "edgeId" : 94351, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94352, "reactomeId" : 10640355, "displayName" : "CDC42 endoplasmic reticulum effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 829, "y" : 375 }, "minX" : 763, "maxX" : 896, "minY" : 360, "maxY" : 458, "prop" : { "x" : 763, "y" : 360, "width" : 133, "height" : 30 }, "textPosition" : { "x" : 762, "y" : 358 }, "connectors" : [ { "edgeId" : 94351, "type" : "INPUT", "segments" : [ { "from" : { "x" : 831, "y" : 396 }, "to" : { "x" : 844, "y" : 458 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94355, "reactomeId" : 10640371, "displayName" : "RHOF:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3189, "y" : 646 }, "minX" : 3052, "maxX" : 3233, "minY" : 629, "maxY" : 712, "prop" : { "x" : 3151, "y" : 635, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 3153, "y" : 636 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3227, "y" : 635 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3227, "y" : 635 } } }, "connectors" : [ { "edgeId" : 94354, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3188, "y" : 660 }, "to" : { "x" : 3188, "y" : 684 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94354, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3199, "y" : 660 }, "to" : { "x" : 3226, "y" : 685 } }, { "from" : { "x" : 3226, "y" : 685 }, "to" : { "x" : 3199, "y" : 705 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3196, "y" : 708 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3196, "y" : 708 } } }, { "edgeId" : 94359, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3148, "y" : 645 }, "to" : { "x" : 3052, "y" : 645 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3141, "y" : 649 }, "b" : { "x" : 3148, "y" : 645 }, "c" : { "x" : 3141, "y" : 641 }, "type" : "ARROW", "centre" : { "x" : 3141, "y" : 641 } } } ] }, { "id" : 94357, "reactomeId" : 10640373, "displayName" : "RHOF:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3184, "y" : 790 }, "minX" : 3052, "maxX" : 3226, "minY" : 751, "maxY" : 801, "prop" : { "x" : 3148, "y" : 779, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 3149, "y" : 780 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3220, "y" : 779 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3220, "y" : 779 } } }, "connectors" : [ { "edgeId" : 94354, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3186, "y" : 776 }, "to" : { "x" : 3193, "y" : 751 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3184, "y" : 768 }, "b" : { "x" : 3186, "y" : 776 }, "c" : { "x" : 3192, "y" : 770 }, "type" : "ARROW", "centre" : { "x" : 3192, "y" : 770 } } }, { "edgeId" : 94359, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3145, "y" : 782 }, "to" : { "x" : 3052, "y" : 763 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94363, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3145, "y" : 793 }, "to" : { "x" : 3086, "y" : 800 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94356, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3111, "y" : 678 }, "minX" : 3094, "maxX" : 3188, "minY" : 664, "maxY" : 691, "prop" : { "x" : 3094, "y" : 665, "width" : 35, "height" : 26 }, "textPosition" : { "x" : 3095, "y" : 667 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3124, "y" : 670 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3124, "y" : 670 } } }, "connectors" : [ { "edgeId" : 94354, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3132, "y" : 679 }, "to" : { "x" : 3188, "y" : 684 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94358, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3107, "y" : 747 }, "minX" : 3088, "maxX" : 3193, "minY" : 734, "maxY" : 760, "prop" : { "x" : 3088, "y" : 735, "width" : 38, "height" : 25 }, "textPosition" : { "x" : 3090, "y" : 737 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3121, "y" : 740 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3121, "y" : 740 } } }, "connectors" : [ { "edgeId" : 94354, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3129, "y" : 747 }, "to" : { "x" : 3193, "y" : 751 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3136, "y" : 743 }, "b" : { "x" : 3129, "y" : 747 }, "c" : { "x" : 3136, "y" : 751 }, "type" : "ARROW", "centre" : { "x" : 3136, "y" : 751 } } } ] }, { "id" : 94361, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3007, "y" : 635 }, "minX" : 2993, "maxX" : 3052, "minY" : 625, "maxY" : 645, "prop" : { "x" : 2993, "y" : 626, "width" : 29, "height" : 19 }, "textPosition" : { "x" : 2998, "y" : 625 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3017, "y" : 631 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3017, "y" : 631 } } }, "connectors" : [ { "edgeId" : 94359, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3025, "y" : 638 }, "to" : { "x" : 3052, "y" : 645 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3033, "y" : 636 }, "b" : { "x" : 3025, "y" : 638 }, "c" : { "x" : 3031, "y" : 644 }, "type" : "ARROW", "centre" : { "x" : 3031, "y" : 644 } } } ] }, { "id" : 94360, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3007, "y" : 779 }, "minX" : 2989, "maxX" : 3052, "minY" : 763, "maxY" : 789, "prop" : { "x" : 2989, "y" : 769, "width" : 36, "height" : 20 }, "textPosition" : { "x" : 2990, "y" : 769 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3020, "y" : 774 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3020, "y" : 774 } } }, "connectors" : [ { "edgeId" : 94359, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3028, "y" : 772 }, "to" : { "x" : 3052, "y" : 763 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 94362, "reactomeId" : 10640430, "displayName" : "RHOF GAPs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2975, "y" : 713 }, "minX" : 2938, "maxX" : 3046, "minY" : 702, "maxY" : 725, "prop" : { "x" : 2938, "y" : 702, "width" : 75, "height" : 23 }, "textPosition" : { "x" : 2953, "y" : 696 }, "connectors" : [ { "edgeId" : 94359, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3019, "y" : 712 }, "to" : { "x" : 3038, "y" : 712 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3042, "y" : 712 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3042, "y" : 712 } } } ] }, { "id" : 94365, "reactomeId" : 10640420, "displayName" : "RHOF:GTP:RHOF effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3188, "y" : 878 }, "minX" : 3141, "maxX" : 3242, "minY" : 854, "maxY" : 896, "prop" : { "x" : 3141, "y" : 860, "width" : 95, "height" : 36 }, "textPosition" : { "x" : 3152, "y" : 847 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3236, "y" : 860 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3236, "y" : 860 } } }, "connectors" : [ { "edgeId" : 94363, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94364, "reactomeId" : 10640418, "displayName" : "RHOF effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2948, "y" : 828 }, "minX" : 2899, "maxX" : 3086, "minY" : 800, "maxY" : 841, "prop" : { "x" : 2899, "y" : 816, "width" : 98, "height" : 25 }, "textPosition" : { "x" : 2916, "y" : 811 }, "connectors" : [ { "edgeId" : 94363, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3003, "y" : 818 }, "to" : { "x" : 3086, "y" : 800 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94367, "reactomeId" : 10637314, "displayName" : "ARHGDIA,ARHGDIB", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 3004, "y" : 2023 }, "minX" : 2967, "maxX" : 3111, "minY" : 1996, "maxY" : 2047, "prop" : { "x" : 2967, "y" : 2000, "width" : 75, "height" : 47 }, "textPosition" : { "x" : 2971, "y" : 2006 }, "connectors" : [ { "edgeId" : 94366, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3048, "y" : 2013 }, "to" : { "x" : 3111, "y" : 1996 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94368, "reactomeId" : 10637860, "displayName" : "RHOH:GTP:RHOH GDIs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2960, "y" : 1933 }, "minX" : 2918, "maxX" : 3008, "minY" : 1909, "maxY" : 1951, "prop" : { "x" : 2918, "y" : 1915, "width" : 84, "height" : 36 }, "textPosition" : { "x" : 2922, "y" : 1916 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3002, "y" : 1915 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3002, "y" : 1915 } } }, "connectors" : [ { "edgeId" : 94366, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94371, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1772, "y" : 2366 }, "minX" : 1752, "maxX" : 1794, "minY" : 2350, "maxY" : 2410, "prop" : { "x" : 1752, "y" : 2351, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1756, "y" : 2355 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1788, "y" : 2356 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1788, "y" : 2356 } } }, "connectors" : [ { "edgeId" : 94369, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1777, "y" : 2384 }, "to" : { "x" : 1788, "y" : 2410 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94370, "reactomeId" : 10583773, "displayName" : "rnd1b", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1741, "y" : 2415 }, "minX" : 1719, "maxX" : 1788, "minY" : 2398, "maxY" : 2426, "prop" : { "x" : 1719, "y" : 2404, "width" : 44, "height" : 22 }, "textPosition" : { "x" : 1722, "y" : 2398 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1763, "y" : 2404 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1763, "y" : 2404 } } }, "connectors" : [ { "edgeId" : 94369, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1766, "y" : 2412 }, "to" : { "x" : 1788, "y" : 2410 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94372, "reactomeId" : 10583775, "displayName" : "RND1:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1897, "y" : 2411 }, "minX" : 1861, "maxX" : 1965, "minY" : 2395, "maxY" : 2422, "prop" : { "x" : 1861, "y" : 2401, "width" : 73, "height" : 21 }, "textPosition" : { "x" : 1862, "y" : 2401 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1934, "y" : 2401 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1934, "y" : 2401 } } }, "connectors" : [ { "edgeId" : 94369, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94373, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1937, "y" : 2412 }, "to" : { "x" : 1965, "y" : 2414 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94375, "reactomeId" : 10640548, "displayName" : "RND1:GTP:RND1 effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2087, "y" : 2414 }, "minX" : 2039, "maxX" : 2142, "minY" : 2391, "maxY" : 2432, "prop" : { "x" : 2039, "y" : 2397, "width" : 97, "height" : 35 }, "textPosition" : { "x" : 2050, "y" : 2383 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2136, "y" : 2397 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2136, "y" : 2397 } } }, "connectors" : [ { "edgeId" : 94373, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94374, "reactomeId" : 10640546, "displayName" : "RND1 effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1930, "y" : 2351 }, "minX" : 1881, "maxX" : 1979, "minY" : 2339, "maxY" : 2414, "prop" : { "x" : 1881, "y" : 2339, "width" : 98, "height" : 24 }, "textPosition" : { "x" : 1898, "y" : 2334 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94373, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1936, "y" : 2369 }, "to" : { "x" : 1965, "y" : 2414 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94377, "reactomeId" : 10640458, "displayName" : "rnd2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2193, "y" : 2413 }, "minX" : 2168, "maxX" : 2250, "minY" : 2396, "maxY" : 2424, "prop" : { "x" : 2168, "y" : 2402, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 2175, "y" : 2402 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2219, "y" : 2402 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2219, "y" : 2402 } } }, "connectors" : [ { "edgeId" : 94376, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2222, "y" : 2413 }, "to" : { "x" : 2250, "y" : 2413 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94379, "reactomeId" : 10640460, "displayName" : "RND2:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2357, "y" : 2414 }, "minX" : 2319, "maxX" : 2432, "minY" : 2397, "maxY" : 2426, "prop" : { "x" : 2319, "y" : 2403, "width" : 77, "height" : 23 }, "textPosition" : { "x" : 2322, "y" : 2405 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2396, "y" : 2403 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2396, "y" : 2403 } } }, "connectors" : [ { "edgeId" : 94376, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94380, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2399, "y" : 2411 }, "to" : { "x" : 2432, "y" : 2410 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94378, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2232, "y" : 2361 }, "minX" : 2214, "maxX" : 2251, "minY" : 2349, "maxY" : 2413, "prop" : { "x" : 2214, "y" : 2350, "width" : 36, "height" : 23 }, "textPosition" : { "x" : 2216, "y" : 2351 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2245, "y" : 2355 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2245, "y" : 2355 } } }, "connectors" : [ { "edgeId" : 94376, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2235, "y" : 2376 }, "to" : { "x" : 2250, "y" : 2413 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94381, "reactomeId" : 10640506, "displayName" : "RND2 effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2419, "y" : 2361 }, "minX" : 2370, "maxX" : 2469, "minY" : 2352, "maxY" : 2410, "prop" : { "x" : 2370, "y" : 2352, "width" : 99, "height" : 18 }, "textPosition" : { "x" : 2387, "y" : 2344 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94380, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2421, "y" : 2376 }, "to" : { "x" : 2432, "y" : 2410 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94382, "reactomeId" : 10640508, "displayName" : "RND2:GTP:RND2 effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2554, "y" : 2414 }, "minX" : 2505, "maxX" : 2610, "minY" : 2392, "maxY" : 2431, "prop" : { "x" : 2505, "y" : 2398, "width" : 99, "height" : 33 }, "textPosition" : { "x" : 2517, "y" : 2382 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2604, "y" : 2398 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2604, "y" : 2398 } } }, "connectors" : [ { "edgeId" : 94380, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94385, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2717, "y" : 2363 }, "minX" : 2699, "maxX" : 2736, "minY" : 2351, "maxY" : 2413, "prop" : { "x" : 2699, "y" : 2352, "width" : 36, "height" : 23 }, "textPosition" : { "x" : 2701, "y" : 2353 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2730, "y" : 2357 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2730, "y" : 2357 } } }, "connectors" : [ { "edgeId" : 94383, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2720, "y" : 2378 }, "to" : { "x" : 2732, "y" : 2413 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94384, "reactomeId" : 10640514, "displayName" : "rnd3a", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2670, "y" : 2413 }, "minX" : 2644, "maxX" : 2732, "minY" : 2396, "maxY" : 2425, "prop" : { "x" : 2644, "y" : 2402, "width" : 52, "height" : 23 }, "textPosition" : { "x" : 2647, "y" : 2403 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2696, "y" : 2402 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2696, "y" : 2402 } } }, "connectors" : [ { "edgeId" : 94383, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2699, "y" : 2413 }, "to" : { "x" : 2732, "y" : 2413 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94386, "reactomeId" : 10640516, "displayName" : "RND3:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2852, "y" : 2412 }, "minX" : 2814, "maxX" : 2935, "minY" : 2395, "maxY" : 2423, "prop" : { "x" : 2814, "y" : 2401, "width" : 77, "height" : 22 }, "textPosition" : { "x" : 2817, "y" : 2402 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2891, "y" : 2401 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2891, "y" : 2401 } } }, "connectors" : [ { "edgeId" : 94383, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94387, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2894, "y" : 2412 }, "to" : { "x" : 2935, "y" : 2414 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94389, "reactomeId" : 10640530, "displayName" : "RND3:GTP:RND3 effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3080, "y" : 2411 }, "minX" : 3032, "maxX" : 3134, "minY" : 2388, "maxY" : 2429, "prop" : { "x" : 3032, "y" : 2394, "width" : 96, "height" : 35 }, "textPosition" : { "x" : 3043, "y" : 2380 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3128, "y" : 2394 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3128, "y" : 2394 } } }, "connectors" : [ { "edgeId" : 94387, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94388, "reactomeId" : 10640528, "displayName" : "RND3 effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2916, "y" : 2346 }, "minX" : 2867, "maxX" : 2966, "minY" : 2336, "maxY" : 2414, "prop" : { "x" : 2867, "y" : 2336, "width" : 99, "height" : 20 }, "textPosition" : { "x" : 2884, "y" : 2329 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94387, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2918, "y" : 2362 }, "to" : { "x" : 2935, "y" : 2414 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94391, "reactomeId" : 10641114, "displayName" : "RAC2:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 918, "y" : 804 }, "minX" : 884, "maxX" : 959, "minY" : 787, "maxY" : 815, "prop" : { "x" : 884, "y" : 793, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 884, "y" : 794 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 953, "y" : 793 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 953, "y" : 793 } } }, "connectors" : [ { "edgeId" : 94390, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94393, "reactomeId" : 10641090, "displayName" : "RAC2:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2109, "y" : 558 }, "minX" : 2014, "maxX" : 2150, "minY" : 541, "maxY" : 590, "prop" : { "x" : 2075, "y" : 547, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 2075, "y" : 548 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2144, "y" : 547 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2144, "y" : 547 } } }, "connectors" : [ { "edgeId" : 94392, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94394, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2076, "y" : 572 }, "to" : { "x" : 2014, "y" : 590 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94395, "reactomeId" : 10641104, "displayName" : "RAC2 mitochondrial effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1725, "y" : 594 }, "minX" : 1660, "maxX" : 2014, "minY" : 574, "maxY" : 614, "prop" : { "x" : 1660, "y" : 574, "width" : 131, "height" : 40 }, "textPosition" : { "x" : 1659, "y" : 576 }, "connectors" : [ { "edgeId" : 94394, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1797, "y" : 593 }, "to" : { "x" : 2014, "y" : 590 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94141, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 437, "y" : 103 }, "minX" : 417, "maxX" : 484, "minY" : 62, "maxY" : 118, "prop" : { "x" : 417, "y" : 88, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 421, "y" : 92 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 453, "y" : 93 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 453, "y" : 93 } } }, "connectors" : [ { "edgeId" : 94140, "type" : "INPUT", "segments" : [ { "from" : { "x" : 454, "y" : 85 }, "to" : { "x" : 484, "y" : 62 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94396, "reactomeId" : 10641106, "displayName" : "RAC2:GTP:RAC2 mitochondrial effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1873, "y" : 649 }, "minX" : 1798, "maxX" : 1954, "minY" : 627, "maxY" : 665, "prop" : { "x" : 1798, "y" : 633, "width" : 150, "height" : 32 }, "textPosition" : { "x" : 1819, "y" : 616 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1948, "y" : 633 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1948, "y" : 633 } } }, "connectors" : [ { "edgeId" : 94394, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94143, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 584, "y" : 116 }, "minX" : 563, "maxX" : 606, "minY" : 64, "maxY" : 131, "prop" : { "x" : 563, "y" : 101, "width" : 42, "height" : 30 }, "textPosition" : { "x" : 567, "y" : 105 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 600, "y" : 106 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 600, "y" : 106 } } }, "connectors" : [ { "edgeId" : 94140, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 578, "y" : 98 }, "to" : { "x" : 564, "y" : 64 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 572, "y" : 93 }, "b" : { "x" : 578, "y" : 98 }, "c" : { "x" : 579, "y" : 90 }, "type" : "ARROW", "centre" : { "x" : 579, "y" : 90 } } } ] }, { "id" : 94398, "reactomeId" : 10641128, "displayName" : "RAC3:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1035, "y" : 808 }, "minX" : 994, "maxX" : 1082, "minY" : 791, "maxY" : 819, "prop" : { "x" : 994, "y" : 797, "width" : 82, "height" : 22 }, "textPosition" : { "x" : 1001, "y" : 798 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1076, "y" : 797 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1076, "y" : 797 } } }, "connectors" : [ { "edgeId" : 94397, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94142, "reactomeId" : 10567530, "displayName" : "RHOA:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 380, "y" : 64 }, "minX" : 303, "maxX" : 484, "minY" : 47, "maxY" : 211, "prop" : { "x" : 344, "y" : 53, "width" : 72, "height" : 22 }, "textPosition" : { "x" : 344, "y" : 54 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 416, "y" : 53 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 416, "y" : 53 } } }, "connectors" : [ { "edgeId" : 94140, "type" : "INPUT", "segments" : [ { "from" : { "x" : 419, "y" : 63 }, "to" : { "x" : 484, "y" : 62 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94146, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 383, "y" : 78 }, "to" : { "x" : 421, "y" : 211 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 389, "y" : 84 }, "b" : { "x" : 383, "y" : 78 }, "c" : { "x" : 381, "y" : 86 }, "type" : "ARROW", "centre" : { "x" : 381, "y" : 86 } } }, { "edgeId" : 94150, "type" : "INPUT", "segments" : [ { "from" : { "x" : 363, "y" : 78 }, "to" : { "x" : 303, "y" : 114 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94145, "reactomeId" : 10636273, "displayName" : "RHOA GEFs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 524, "y" : 155 }, "minX" : 482, "maxX" : 567, "minY" : 73, "maxY" : 169, "prop" : { "x" : 482, "y" : 142, "width" : 85, "height" : 27 }, "textPosition" : { "x" : 486, "y" : 145 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94140, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 524, "y" : 136 }, "to" : { "x" : 525, "y" : 81 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 525, "y" : 77 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 525, "y" : 77 } } } ] }, { "id" : 94400, "reactomeId" : 10641080, "displayName" : "RHOC:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 638, "y" : 876 }, "minX" : 599, "maxX" : 683, "minY" : 859, "maxY" : 887, "prop" : { "x" : 599, "y" : 865, "width" : 78, "height" : 22 }, "textPosition" : { "x" : 603, "y" : 866 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 677, "y" : 865 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 677, "y" : 865 } } }, "connectors" : [ { "edgeId" : 94399, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94144, "reactomeId" : 10567532, "displayName" : "RHOA:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 643, "y" : 65 }, "minX" : 564, "maxX" : 698, "minY" : 48, "maxY" : 212, "prop" : { "x" : 608, "y" : 54, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 608, "y" : 55 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 679, "y" : 54 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 679, "y" : 54 } } }, "connectors" : [ { "edgeId" : 94140, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 605, "y" : 64 }, "to" : { "x" : 564, "y" : 64 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 598, "y" : 68 }, "b" : { "x" : 605, "y" : 64 }, "c" : { "x" : 598, "y" : 60 }, "type" : "ARROW", "centre" : { "x" : 598, "y" : 60 } } }, { "edgeId" : 94146, "type" : "INPUT", "segments" : [ { "from" : { "x" : 639, "y" : 79 }, "to" : { "x" : 592, "y" : 212 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94153, "type" : "INPUT", "segments" : [ { "from" : { "x" : 682, "y" : 67 }, "to" : { "x" : 698, "y" : 69 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94156, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94147, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 611, "y" : 247 }, "minX" : 591, "maxX" : 632, "minY" : 212, "maxY" : 260, "prop" : { "x" : 591, "y" : 235, "width" : 40, "height" : 25 }, "textPosition" : { "x" : 594, "y" : 237 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 626, "y" : 240 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 626, "y" : 240 } } }, "connectors" : [ { "edgeId" : 94146, "type" : "INPUT", "segments" : [ { "from" : { "x" : 604, "y" : 232 }, "to" : { "x" : 592, "y" : 212 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 94403, "reactomeId" : 10641243, "displayName" : "p-Y254-RHOU:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 893, "y" : 2069 }, "minX" : 831, "maxX" : 962, "minY" : 2051, "maxY" : 2082, "prop" : { "x" : 831, "y" : 2057, "width" : 125, "height" : 25 }, "textPosition" : { "x" : 833, "y" : 2061 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 956, "y" : 2057 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 956, "y" : 2057 } } }, "connectors" : [ { "edgeId" : 94401, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94402, "reactomeId" : 10641239, "displayName" : "p-Y254-RHOU:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1656, "y" : 2414 }, "minX" : 1619, "maxX" : 1700, "minY" : 2391, "maxY" : 2432, "prop" : { "x" : 1619, "y" : 2397, "width" : 75, "height" : 35 }, "textPosition" : { "x" : 1620, "y" : 2397 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1694, "y" : 2397 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1694, "y" : 2397 } } }, "connectors" : [ { "edgeId" : 94401, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94149, "reactomeId" : 10636418, "displayName" : "RHOA GAPs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 525, "y" : 279 }, "minX" : 486, "maxX" : 565, "minY" : 224, "maxY" : 290, "prop" : { "x" : 486, "y" : 268, "width" : 79, "height" : 22 }, "textPosition" : { "x" : 486, "y" : 268 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94146, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 525, "y" : 262 }, "to" : { "x" : 526, "y" : 232 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 526, "y" : 228 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 526, "y" : 228 } } } ] }, { "id" : 94148, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 403, "y" : 256 }, "minX" : 231, "maxX" : 421, "minY" : 211, "maxY" : 400, "prop" : { "x" : 388, "y" : 244, "width" : 31, "height" : 24 }, "textPosition" : { "x" : 394, "y" : 245 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 414, "y" : 249 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 414, "y" : 249 } } }, "connectors" : [ { "edgeId" : 94146, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 407, "y" : 241 }, "to" : { "x" : 421, "y" : 211 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 406, "y" : 233 }, "b" : { "x" : 407, "y" : 241 }, "c" : { "x" : 414, "y" : 236 }, "type" : "ARROW", "centre" : { "x" : 414, "y" : 236 } } }, { "edgeId" : 94294, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 388, "y" : 271 }, "to" : { "x" : 231, "y" : 400 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 385, "y" : 278 }, "b" : { "x" : 388, "y" : 271 }, "c" : { "x" : 380, "y" : 272 }, "type" : "ARROW", "centre" : { "x" : 380, "y" : 272 } } } ] }, { "id" : 94151, "reactomeId" : 10637314, "displayName" : "ARHGDIA,ARHGDIB", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 231, "y" : 120 }, "minX" : 188, "maxX" : 913, "minY" : 0, "maxY" : 134, "prop" : { "x" : 188, "y" : 107, "width" : 87, "height" : 27 }, "textPosition" : { "x" : 198, "y" : 103 }, "connectors" : [ { "edgeId" : 94150, "type" : "INPUT", "segments" : [ { "from" : { "x" : 281, "y" : 116 }, "to" : { "x" : 303, "y" : 114 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94203, "type" : "INPUT", "segments" : [ { "from" : { "x" : 231, "y" : 101 }, "to" : { "x" : 232, "y" : 0 } }, { "from" : { "x" : 232, "y" : 0 }, "to" : { "x" : 894, "y" : 2 } }, { "from" : { "x" : 894, "y" : 2 }, "to" : { "x" : 913, "y" : 131 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94152, "reactomeId" : 10637318, "displayName" : "RHOA GDIs:RHOA:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 268, "y" : 261 }, "minX" : 227, "maxX" : 316, "minY" : 236, "maxY" : 280, "prop" : { "x" : 227, "y" : 242, "width" : 83, "height" : 38 }, "textPosition" : { "x" : 229, "y" : 245 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 310, "y" : 242 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 310, "y" : 242 } } }, "connectors" : [ { "edgeId" : 94150, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94155, "reactomeId" : 10637396, "displayName" : "RHOA:GTP:cytosolic RHOA effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 799, "y" : 63 }, "minX" : 752, "maxX" : 852, "minY" : 32, "maxY" : 89, "prop" : { "x" : 752, "y" : 38, "width" : 94, "height" : 51 }, "textPosition" : { "x" : 762, "y" : 26 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 846, "y" : 38 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 846, "y" : 38 } } }, "connectors" : [ { "edgeId" : 94153, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94154, "reactomeId" : 10637394, "displayName" : "RHOA plasma membrane effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 736, "y" : 155 }, "minX" : 683, "maxX" : 789, "minY" : 69, "maxY" : 178, "prop" : { "x" : 683, "y" : 133, "width" : 106, "height" : 45 }, "textPosition" : { "x" : 688, "y" : 131 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94153, "type" : "INPUT", "segments" : [ { "from" : { "x" : 726, "y" : 127 }, "to" : { "x" : 698, "y" : 69 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94157, "reactomeId" : 10637322, "displayName" : "RHOA:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 660, "y" : 308 }, "minX" : 625, "maxX" : 743, "minY" : 263, "maxY" : 319, "prop" : { "x" : 625, "y" : 297, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 625, "y" : 298 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 696, "y" : 297 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 696, "y" : 297 } } }, "connectors" : [ { "edgeId" : 94156, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94158, "type" : "INPUT", "segments" : [ { "from" : { "x" : 680, "y" : 294 }, "to" : { "x" : 743, "y" : 263 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94159, "reactomeId" : 10637354, "displayName" : "RHOA endoplasmic reticulum effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 770, "y" : 319 }, "minX" : 708, "maxX" : 832, "minY" : 263, "maxY" : 337, "prop" : { "x" : 708, "y" : 301, "width" : 124, "height" : 36 }, "textPosition" : { "x" : 724, "y" : 288 }, "connectors" : [ { "edgeId" : 94158, "type" : "INPUT", "segments" : [ { "from" : { "x" : 761, "y" : 295 }, "to" : { "x" : 743, "y" : 263 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94160, "reactomeId" : 10637356, "displayName" : "RHOA:GTP:RHOA endoplasmic reticulum effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 955, "y" : 312 }, "minX" : 897, "maxX" : 1019, "minY" : 281, "maxY" : 337, "prop" : { "x" : 897, "y" : 287, "width" : 116, "height" : 50 }, "textPosition" : { "x" : 899, "y" : 274 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1013, "y" : 287 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1013, "y" : 287 } } }, "connectors" : [ { "edgeId" : 94158, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94163, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 121, "y" : 949 }, "minX" : 52, "maxX" : 142, "minY" : 936, "maxY" : 975, "prop" : { "x" : 102, "y" : 937, "width" : 39, "height" : 24 }, "textPosition" : { "x" : 105, "y" : 938 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 136, "y" : 942 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 136, "y" : 942 } } }, "connectors" : [ { "edgeId" : 94161, "type" : "INPUT", "segments" : [ { "from" : { "x" : 99, "y" : 956 }, "to" : { "x" : 52, "y" : 975 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94162, "reactomeId" : 10637400, "displayName" : "RHOB:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 44, "y" : 930 }, "minX" : 9, "maxX" : 184, "minY" : 891, "maxY" : 975, "prop" : { "x" : 9, "y" : 919, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 21, "y" : 906 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 80, "y" : 919 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 80, "y" : 919 } } }, "connectors" : [ { "edgeId" : 94161, "type" : "INPUT", "segments" : [ { "from" : { "x" : 45, "y" : 944 }, "to" : { "x" : 52, "y" : 975 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94167, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 83, "y" : 925 }, "to" : { "x" : 184, "y" : 914 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 89, "y" : 920 }, "b" : { "x" : 83, "y" : 925 }, "c" : { "x" : 90, "y" : 928 }, "type" : "ARROW", "centre" : { "x" : 90, "y" : 928 } } }, { "edgeId" : 94171, "type" : "INPUT", "segments" : [ { "from" : { "x" : 55, "y" : 916 }, "to" : { "x" : 85, "y" : 891 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94165, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 140, "y" : 1076 }, "minX" : 55, "maxX" : 162, "minY" : 1062, "maxY" : 1090, "prop" : { "x" : 120, "y" : 1063, "width" : 41, "height" : 27 }, "textPosition" : { "x" : 123, "y" : 1066 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 156, "y" : 1068 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 156, "y" : 1068 } } }, "connectors" : [ { "edgeId" : 94161, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 117, "y" : 1073 }, "to" : { "x" : 55, "y" : 1064 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 110, "y" : 1076 }, "b" : { "x" : 117, "y" : 1073 }, "c" : { "x" : 111, "y" : 1068 }, "type" : "ARROW", "centre" : { "x" : 111, "y" : 1068 } } } ] }, { "id" : 94164, "reactomeId" : 10637410, "displayName" : "RHOB:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 44, "y" : 1111 }, "minX" : 9, "maxX" : 187, "minY" : 1064, "maxY" : 1135, "prop" : { "x" : 9, "y" : 1100, "width" : 70, "height" : 22 }, "textPosition" : { "x" : 9, "y" : 1101 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 79, "y" : 1100 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 79, "y" : 1100 } } }, "connectors" : [ { "edgeId" : 94339, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94161, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 46, "y" : 1097 }, "to" : { "x" : 55, "y" : 1064 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 44, "y" : 1089 }, "b" : { "x" : 46, "y" : 1097 }, "c" : { "x" : 52, "y" : 1091 }, "type" : "ARROW", "centre" : { "x" : 52, "y" : 1091 } } }, { "edgeId" : 94167, "type" : "INPUT", "segments" : [ { "from" : { "x" : 82, "y" : 1109 }, "to" : { "x" : 187, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94174, "type" : "INPUT", "segments" : [ { "from" : { "x" : 63, "y" : 1125 }, "to" : { "x" : 86, "y" : 1135 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94166, "reactomeId" : 10637417, "displayName" : "RHOB GEFs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 134, "y" : 1014 }, "minX" : 67, "maxX" : 171, "minY" : 1003, "maxY" : 1025, "prop" : { "x" : 97, "y" : 1003, "width" : 74, "height" : 22 }, "textPosition" : { "x" : 111, "y" : 997 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94161, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 91, "y" : 1016 }, "to" : { "x" : 75, "y" : 1018 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 71, "y" : 1019 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 71, "y" : 1019 } } } ] }, { "id" : 94169, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 242, "y" : 897 }, "minX" : 184, "maxX" : 259, "minY" : 884, "maxY" : 914, "prop" : { "x" : 227, "y" : 885, "width" : 31, "height" : 24 }, "textPosition" : { "x" : 233, "y" : 886 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 253, "y" : 890 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 253, "y" : 890 } } }, "connectors" : [ { "edgeId" : 94167, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 224, "y" : 901 }, "to" : { "x" : 184, "y" : 914 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 219, "y" : 907 }, "b" : { "x" : 224, "y" : 901 }, "c" : { "x" : 216, "y" : 899 }, "type" : "ARROW", "centre" : { "x" : 216, "y" : 899 } } } ] }, { "id" : 94168, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 233, "y" : 1133 }, "minX" : 187, "maxX" : 255, "minY" : 1105, "maxY" : 1147, "prop" : { "x" : 213, "y" : 1120, "width" : 41, "height" : 27 }, "textPosition" : { "x" : 216, "y" : 1123 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 249, "y" : 1125 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 249, "y" : 1125 } } }, "connectors" : [ { "edgeId" : 94167, "type" : "INPUT", "segments" : [ { "from" : { "x" : 210, "y" : 1120 }, "to" : { "x" : 187, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 94170, "reactomeId" : 10637412, "displayName" : "RHOB GAPs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 290, "y" : 1023 }, "minX" : 202, "maxX" : 328, "minY" : 1012, "maxY" : 1034, "prop" : { "x" : 252, "y" : 1012, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 267, "y" : 1006 }, "connectors" : [ { "edgeId" : 94167, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 246, "y" : 1023 }, "to" : { "x" : 210, "y" : 1023 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 206, "y" : 1023 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 206, "y" : 1023 } } } ] }, { "id" : 94173, "reactomeId" : 10637406, "displayName" : "RHOB:GDP:RHOB GDIs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 191, "y" : 843 }, "minX" : 151, "maxX" : 237, "minY" : 820, "maxY" : 860, "prop" : { "x" : 151, "y" : 826, "width" : 80, "height" : 34 }, "textPosition" : { "x" : 153, "y" : 825 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 231, "y" : 826 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 231, "y" : 826 } } }, "connectors" : [ { "edgeId" : 94171, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94172, "reactomeId" : 10637402, "displayName" : "arhgdig", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 90, "y" : 806 }, "minX" : 54, "maxX" : 133, "minY" : 789, "maxY" : 891, "prop" : { "x" : 54, "y" : 795, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 62, "y" : 795 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 127, "y" : 795 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 127, "y" : 795 } } }, "connectors" : [ { "edgeId" : 94171, "type" : "INPUT", "segments" : [ { "from" : { "x" : 89, "y" : 823 }, "to" : { "x" : 85, "y" : 891 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94175, "reactomeId" : 10637422, "displayName" : "RHOB effectors (plasma membrane)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 161, "y" : 1185 }, "minX" : 86, "maxX" : 224, "minY" : 1135, "maxY" : 1203, "prop" : { "x" : 98, "y" : 1167, "width" : 126, "height" : 36 }, "textPosition" : { "x" : 108, "y" : 1161 }, "connectors" : [ { "edgeId" : 94174, "type" : "INPUT", "segments" : [ { "from" : { "x" : 134, "y" : 1161 }, "to" : { "x" : 86, "y" : 1135 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94176, "reactomeId" : 10637424, "displayName" : "RHOB:GTP:cytosolic RHOB effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 153, "y" : 1297 }, "minX" : 105, "maxX" : 208, "minY" : 1266, "maxY" : 1323, "prop" : { "x" : 105, "y" : 1272, "width" : 97, "height" : 51 }, "textPosition" : { "x" : 116, "y" : 1260 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 202, "y" : 1272 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 202, "y" : 1272 } } }, "connectors" : [ { "edgeId" : 94174, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94179, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 120, "y" : 1470 }, "minX" : 54, "maxX" : 140, "minY" : 1456, "maxY" : 1483, "prop" : { "x" : 101, "y" : 1457, "width" : 38, "height" : 26 }, "textPosition" : { "x" : 104, "y" : 1459 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 134, "y" : 1462 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 134, "y" : 1462 } } }, "connectors" : [ { "edgeId" : 94177, "type" : "INPUT", "segments" : [ { "from" : { "x" : 98, "y" : 1472 }, "to" : { "x" : 54, "y" : 1479 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94178, "reactomeId" : 10637428, "displayName" : "RHOC:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 58, "y" : 1424 }, "minX" : 22, "maxX" : 230, "minY" : 1400, "maxY" : 1479, "prop" : { "x" : 22, "y" : 1413, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 22, "y" : 1414 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 95, "y" : 1413 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 95, "y" : 1413 } } }, "connectors" : [ { "edgeId" : 94177, "type" : "INPUT", "segments" : [ { "from" : { "x" : 57, "y" : 1438 }, "to" : { "x" : 54, "y" : 1479 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94183, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 98, "y" : 1428 }, "to" : { "x" : 230, "y" : 1445 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 105, "y" : 1425 }, "b" : { "x" : 98, "y" : 1428 }, "c" : { "x" : 104, "y" : 1433 }, "type" : "ARROW", "centre" : { "x" : 104, "y" : 1433 } } }, { "edgeId" : 94187, "type" : "INPUT", "segments" : [ { "from" : { "x" : 98, "y" : 1416 }, "to" : { "x" : 180, "y" : 1400 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94181, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 142, "y" : 1567 }, "minX" : 52, "maxX" : 162, "minY" : 1552, "maxY" : 1581, "prop" : { "x" : 123, "y" : 1553, "width" : 38, "height" : 28 }, "textPosition" : { "x" : 125, "y" : 1556 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 156, "y" : 1558 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 156, "y" : 1558 } } }, "connectors" : [ { "edgeId" : 94177, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 120, "y" : 1566 }, "to" : { "x" : 52, "y" : 1565 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 113, "y" : 1570 }, "b" : { "x" : 120, "y" : 1566 }, "c" : { "x" : 113, "y" : 1562 }, "type" : "ARROW", "centre" : { "x" : 113, "y" : 1562 } } } ] }, { "id" : 94180, "reactomeId" : 10615491, "displayName" : "RHOC:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 52, "y" : 1616 }, "minX" : 16, "maxX" : 231, "minY" : 1565, "maxY" : 1656, "prop" : { "x" : 16, "y" : 1605, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 17, "y" : 1606 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 89, "y" : 1605 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 89, "y" : 1605 } } }, "connectors" : [ { "edgeId" : 94399, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94177, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 52, "y" : 1602 }, "to" : { "x" : 52, "y" : 1565 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 48, "y" : 1595 }, "b" : { "x" : 52, "y" : 1602 }, "c" : { "x" : 56, "y" : 1595 }, "type" : "ARROW", "centre" : { "x" : 56, "y" : 1595 } } }, { "edgeId" : 94183, "type" : "INPUT", "segments" : [ { "from" : { "x" : 92, "y" : 1610 }, "to" : { "x" : 231, "y" : 1587 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94190, "type" : "INPUT", "segments" : [ { "from" : { "x" : 57, "y" : 1630 }, "to" : { "x" : 72, "y" : 1656 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94182, "reactomeId" : 10637438, "displayName" : "RHOC GEFs", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 144, "y" : 1515 }, "minX" : 59, "maxX" : 182, "minY" : 1504, "maxY" : 1526, "prop" : { "x" : 106, "y" : 1504, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 121, "y" : 1498 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94177, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 100, "y" : 1515 }, "to" : { "x" : 67, "y" : 1516 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 63, "y" : 1517 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 63, "y" : 1517 } } } ] }, { "id" : 94185, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 270, "y" : 1420 }, "minX" : 230, "maxX" : 287, "minY" : 1407, "maxY" : 1445, "prop" : { "x" : 255, "y" : 1408, "width" : 31, "height" : 24 }, "textPosition" : { "x" : 261, "y" : 1409 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 281, "y" : 1413 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 281, "y" : 1413 } } }, "connectors" : [ { "edgeId" : 94183, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 252, "y" : 1429 }, "to" : { "x" : 230, "y" : 1445 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 249, "y" : 1436 }, "b" : { "x" : 252, "y" : 1429 }, "c" : { "x" : 244, "y" : 1430 }, "type" : "ARROW", "centre" : { "x" : 244, "y" : 1430 } } } ] }, { "id" : 94184, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 264, "y" : 1623 }, "minX" : 231, "maxX" : 284, "minY" : 1587, "maxY" : 1636, "prop" : { "x" : 245, "y" : 1610, "width" : 38, "height" : 26 }, "textPosition" : { "x" : 247, "y" : 1612 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 278, "y" : 1615 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 278, "y" : 1615 } } }, "connectors" : [ { "edgeId" : 94183, "type" : "INPUT", "segments" : [ { "from" : { "x" : 252, "y" : 1607 }, "to" : { "x" : 231, "y" : 1587 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 94186, "reactomeId" : 10637449, "displayName" : "RHOC GAPs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 327, "y" : 1512 }, "minX" : 239, "maxX" : 367, "minY" : 1501, "maxY" : 1523, "prop" : { "x" : 288, "y" : 1501, "width" : 79, "height" : 22 }, "textPosition" : { "x" : 288, "y" : 1501 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94183, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 282, "y" : 1511 }, "to" : { "x" : 247, "y" : 1511 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 243, "y" : 1511 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 243, "y" : 1511 } } } ] }, { "id" : 94189, "reactomeId" : 10637434, "displayName" : "RHOC:GDP:ARHGDIA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 368, "y" : 1365 }, "minX" : 327, "maxX" : 416, "minY" : 1341, "maxY" : 1383, "prop" : { "x" : 327, "y" : 1347, "width" : 83, "height" : 36 }, "textPosition" : { "x" : 330, "y" : 1348 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 410, "y" : 1347 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 410, "y" : 1347 } } }, "connectors" : [ { "edgeId" : 94187, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94188, "reactomeId" : 10573592, "displayName" : "arhgdia", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 144, "y" : 1364 }, "minX" : 113, "maxX" : 182, "minY" : 1347, "maxY" : 1400, "prop" : { "x" : 113, "y" : 1353, "width" : 63, "height" : 22 }, "textPosition" : { "x" : 116, "y" : 1353 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 176, "y" : 1353 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 176, "y" : 1353 } } }, "connectors" : [ { "edgeId" : 94187, "type" : "INPUT", "segments" : [ { "from" : { "x" : 155, "y" : 1378 }, "to" : { "x" : 180, "y" : 1400 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94191, "reactomeId" : 10637443, "displayName" : "RHOC effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 158, "y" : 1683 }, "minX" : 72, "maxX" : 207, "minY" : 1656, "maxY" : 1694, "prop" : { "x" : 109, "y" : 1673, "width" : 98, "height" : 21 }, "textPosition" : { "x" : 126, "y" : 1666 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94190, "type" : "INPUT", "segments" : [ { "from" : { "x" : 124, "y" : 1667 }, "to" : { "x" : 72, "y" : 1656 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94192, "reactomeId" : 10637445, "displayName" : "RHOC:GTP:RHOC effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 56, "y" : 1807 }, "minX" : 4, "maxX" : 115, "minY" : 1785, "maxY" : 1824, "prop" : { "x" : 4, "y" : 1791, "width" : 105, "height" : 33 }, "textPosition" : { "x" : 5, "y" : 1789 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 109, "y" : 1791 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 109, "y" : 1791 } } }, "connectors" : [ { "edgeId" : 94190, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94195, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1002, "y" : 102 }, "minX" : 982, "maxX" : 1025, "minY" : 65, "maxY" : 114, "prop" : { "x" : 982, "y" : 91, "width" : 40, "height" : 23 }, "textPosition" : { "x" : 986, "y" : 92 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1017, "y" : 96 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1017, "y" : 96 } } }, "connectors" : [ { "edgeId" : 94193, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1009, "y" : 88 }, "to" : { "x" : 1025, "y" : 65 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94194, "reactomeId" : 10600543, "displayName" : "RAC1:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 949, "y" : 62 }, "minX" : 913, "maxX" : 1025, "minY" : 45, "maxY" : 173, "prop" : { "x" : 914, "y" : 51, "width" : 70, "height" : 22 }, "textPosition" : { "x" : 914, "y" : 52 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 984, "y" : 51 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 984, "y" : 51 } } }, "connectors" : [ { "edgeId" : 94193, "type" : "INPUT", "segments" : [ { "from" : { "x" : 987, "y" : 63 }, "to" : { "x" : 1025, "y" : 65 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94199, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 951, "y" : 76 }, "to" : { "x" : 978, "y" : 173 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 957, "y" : 82 }, "b" : { "x" : 951, "y" : 76 }, "c" : { "x" : 949, "y" : 84 }, "type" : "ARROW", "centre" : { "x" : 949, "y" : 84 } } }, { "edgeId" : 94203, "type" : "INPUT", "segments" : [ { "from" : { "x" : 943, "y" : 76 }, "to" : { "x" : 913, "y" : 131 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94197, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1136, "y" : 108 }, "minX" : 1101, "maxX" : 1157, "minY" : 60, "maxY" : 120, "prop" : { "x" : 1116, "y" : 96, "width" : 40, "height" : 24 }, "textPosition" : { "x" : 1119, "y" : 97 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1151, "y" : 101 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1151, "y" : 101 } } }, "connectors" : [ { "edgeId" : 94193, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1127, "y" : 93 }, "to" : { "x" : 1101, "y" : 60 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1120, "y" : 90 }, "b" : { "x" : 1127, "y" : 93 }, "c" : { "x" : 1126, "y" : 85 }, "type" : "ARROW", "centre" : { "x" : 1126, "y" : 85 } } } ] }, { "id" : 94196, "reactomeId" : 10567498, "displayName" : "RAC1:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1214, "y" : 75 }, "minX" : 1101, "maxX" : 1306, "minY" : 58, "maxY" : 185, "prop" : { "x" : 1180, "y" : 64, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 1180, "y" : 65 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1249, "y" : 64 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1249, "y" : 64 } } }, "connectors" : [ { "edgeId" : 94344, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94193, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1177, "y" : 70 }, "to" : { "x" : 1101, "y" : 60 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1170, "y" : 73 }, "b" : { "x" : 1177, "y" : 70 }, "c" : { "x" : 1171, "y" : 65 }, "type" : "ARROW", "centre" : { "x" : 1171, "y" : 65 } } }, { "edgeId" : 94199, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1205, "y" : 89 }, "to" : { "x" : 1129, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 94205, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1252, "y" : 85 }, "to" : { "x" : 1306, "y" : 102 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94198, "reactomeId" : 10637466, "displayName" : "RAC1 GEFs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1064, "y" : 136 }, "minX" : 1028, "maxX" : 1101, "minY" : 67, "maxY" : 147, "prop" : { "x" : 1028, "y" : 125, "width" : 73, "height" : 22 }, "textPosition" : { "x" : 1042, "y" : 119 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 204 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 94193, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1064, "y" : 119 }, "to" : { "x" : 1065, "y" : 75 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1065, "y" : 71 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1065, "y" : 71 } } } ] }, { "id" : 94201, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 917, "y" : 207 }, "minX" : 902, "maxX" : 978, "minY" : 173, "maxY" : 219, "prop" : { "x" : 902, "y" : 195, "width" : 31, "height" : 24 }, "textPosition" : { "x" : 908, "y" : 196 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 928, "y" : 200 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 928, "y" : 200 } } }, "connectors" : [ { "edgeId" : 94199, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 936, "y" : 198 }, "to" : { "x" : 978, "y" : 173 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 940, "y" : 191 }, "b" : { "x" : 936, "y" : 198 }, "c" : { "x" : 944, "y" : 198 }, "type" : "ARROW", "centre" : { "x" : 944, "y" : 198 } } } ] }, { "id" : 94200, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1170, "y" : 218 }, "minX" : 1129, "maxX" : 1193, "minY" : 185, "maxY" : 233, "prop" : { "x" : 1149, "y" : 203, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1153, "y" : 207 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1187, "y" : 208 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1187, "y" : 208 } } }, "connectors" : [ { "edgeId" : 94199, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1151, "y" : 200 }, "to" : { "x" : 1129, "y" : 185 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 94202, "reactomeId" : 10637509, "displayName" : "RAC1 GAPs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1065, "y" : 229 }, "minX" : 1028, "maxX" : 1103, "minY" : 183, "maxY" : 240, "prop" : { "x" : 1028, "y" : 218, "width" : 75, "height" : 22 }, "textPosition" : { "x" : 1043, "y" : 212 }, "connectors" : [ { "edgeId" : 94199, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1065, "y" : 212 }, "to" : { "x" : 1067, "y" : 191 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1067, "y" : 187 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1067, "y" : 187 } } } ] }, { "id" : 94204, "reactomeId" : 10637566, "displayName" : "RAC1:GDP:RAC1 GDIs", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 842, "y" : 241 }, "minX" : 805, "maxX" : 886, "minY" : 217, "maxY" : 260, "prop" : { "x" : 805, "y" : 223, "width" : 75, "height" : 37 }, "textPosition" : { "x" : 805, "y" : 225 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 880, "y" : 223 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 880, "y" : 223 } } }, "connectors" : [ { "edgeId" : 94203, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94207, "reactomeId" : 10637562, "displayName" : "RAC1:GTP:RAC1 effectors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1420, "y" : 64 }, "minX" : 1372, "maxX" : 1474, "minY" : 39, "maxY" : 84, "prop" : { "x" : 1372, "y" : 45, "width" : 96, "height" : 39 }, "textPosition" : { "x" : 1384, "y" : 35 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1468, "y" : 45 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1468, "y" : 45 } } }, "connectors" : [ { "edgeId" : 94205, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 94206, "reactomeId" : 10637560, "displayName" : "RAC1 effectors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1280, "y" : 161 }, "minX" : 1233, "maxX" : 1328, "minY" : 102, "maxY" : 172, "prop" : { "x" : 1233, "y" : 150, "width" : 95, "height" : 22 }, "textPosition" : { "x" : 1248, "y" : 144 }, "connectors" : [ { "edgeId" : 94205, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1284, "y" : 144 }, "to" : { "x" : 1306, "y" : 102 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 94336, "reactomeId" : 10638011, "displayName" : "RAC3 binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3145, "y" : 548 }, "minX" : 3119, "maxX" : 3176, "minY" : 519, "maxY" : 579, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3119, "y" : 519 }, "to" : { "x" : 3145, "y" : 548 } }, { "from" : { "x" : 3145, "y" : 548 }, "to" : { "x" : 3176, "y" : 579 } } ], "endShape" : { "a" : { "x" : 3168, "y" : 577 }, "b" : { "x" : 3176, "y" : 579 }, "c" : { "x" : 3174, "y" : 571 }, "type" : "ARROW", "centre" : { "x" : 3174, "y" : 571 } }, "reactionShape" : { "c" : { "x" : 3145, "y" : 548 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3145, "y" : 548 } }, "inputs" : [ { "id" : 94326, "points" : [ { "x" : 3145, "y" : 510 } ] }, { "id" : 94337, "points" : [ { "x" : 3073, "y" : 548 } ] } ], "outputs" : [ { "id" : 94338 } ] }, { "id" : 94208, "reactomeId" : 10637631, "displayName" : "CDC42 GEFs activate CDC42", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1703, "y" : 66 }, "minX" : 1663, "maxX" : 1753, "minY" : 60, "maxY" : 72, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1663, "y" : 66 }, "to" : { "x" : 1703, "y" : 66 } }, { "from" : { "x" : 1703, "y" : 66 }, "to" : { "x" : 1753, "y" : 64 } } ], "reactionShape" : { "a" : { "x" : 1697, "y" : 60 }, "b" : { "x" : 1709, "y" : 72 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1703, "y" : 66 } }, "inputs" : [ { "id" : 94209, "points" : [ { "x" : 1611, "y" : 63 } ] }, { "id" : 94210, "points" : [ { "x" : 1621, "y" : 98 } ] } ], "outputs" : [ { "id" : 94211, "points" : [ { "x" : 1798, "y" : 63 } ] }, { "id" : 94212, "points" : [ { "x" : 1775, "y" : 105 } ] } ], "catalysts" : [ { "id" : 94213, "points" : [ { "x" : 1697, "y" : 127 } ] } ] }, { "id" : 94339, "reactomeId" : 10640321, "displayName" : "RHOB translocates to the endosome membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 430, "y" : 1207 }, "minX" : 82, "maxX" : 2239, "minY" : 631, "maxY" : 1213, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 82, "y" : 1119 }, "to" : { "x" : 430, "y" : 1207 } }, { "from" : { "x" : 430, "y" : 1207 }, "to" : { "x" : 2239, "y" : 631 } } ], "endShape" : { "a" : { "x" : 2234, "y" : 637 }, "b" : { "x" : 2239, "y" : 631 }, "c" : { "x" : 2231, "y" : 629 }, "type" : "ARROW", "centre" : { "x" : 2231, "y" : 629 } }, "reactionShape" : { "a" : { "x" : 424, "y" : 1201 }, "b" : { "x" : 436, "y" : 1213 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 430, "y" : 1207 } }, "inputs" : [ { "id" : 94164 } ], "outputs" : [ { "id" : 94340 } ] }, { "id" : 94341, "reactomeId" : 10640319, "displayName" : "RHOB binds effectors on endosomes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2322, "y" : 710 }, "minX" : 2268, "maxX" : 2386, "minY" : 684, "maxY" : 716, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2268, "y" : 684 }, "to" : { "x" : 2322, "y" : 710 } }, { "from" : { "x" : 2322, "y" : 710 }, "to" : { "x" : 2386, "y" : 692 } } ], "endShape" : { "a" : { "x" : 2380, "y" : 698 }, "b" : { "x" : 2386, "y" : 692 }, "c" : { "x" : 2378, "y" : 690 }, "type" : "ARROW", "centre" : { "x" : 2378, "y" : 690 } }, "reactionShape" : { "c" : { "x" : 2322, "y" : 710 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2322, "y" : 710 } }, "inputs" : [ { "id" : 94342, "points" : [ { "x" : 2225, "y" : 723 } ] }, { "id" : 94340, "points" : [ { "x" : 2270, "y" : 631 } ] } ], "outputs" : [ { "id" : 94343 } ] }, { "id" : 94214, "reactomeId" : 10637640, "displayName" : "CDC42 GAPs stimulate CDC42 GTPase activity", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1698, "y" : 207 }, "minX" : 1577, "maxX" : 1812, "minY" : 189, "maxY" : 213, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1812, "y" : 189 }, "to" : { "x" : 1698, "y" : 207 } }, { "from" : { "x" : 1698, "y" : 207 }, "to" : { "x" : 1577, "y" : 198 } } ], "reactionShape" : { "a" : { "x" : 1692, "y" : 201 }, "b" : { "x" : 1704, "y" : 213 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1698, "y" : 207 } }, "inputs" : [ { "id" : 94211, "points" : [ { "x" : 1840, "y" : 78 } ] }, { "id" : 94215, "points" : [ { "x" : 1806, "y" : 252 } ] } ], "outputs" : [ { "id" : 94209, "points" : [ { "x" : 1569, "y" : 78 } ] }, { "id" : 94216, "points" : [ { "x" : 1547, "y" : 250 } ] } ], "catalysts" : [ { "id" : 94217, "points" : [ { "x" : 1697, "y" : 273 } ] } ] }, { "id" : 94344, "reactomeId" : 10640328, "displayName" : "RAC1 translocates to the endoplasmic reticulum membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1204, "y" : 329 }, "minX" : 1006, "maxX" : 1213, "minY" : 89, "maxY" : 407, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1213, "y" : 89 }, "to" : { "x" : 1204, "y" : 329 } }, { "from" : { "x" : 1204, "y" : 329 }, "to" : { "x" : 1006, "y" : 407 } } ], "endShape" : { "a" : { "x" : 1011, "y" : 401 }, "b" : { "x" : 1006, "y" : 407 }, "c" : { "x" : 1014, "y" : 408 }, "type" : "ARROW", "centre" : { "x" : 1014, "y" : 408 } }, "reactionShape" : { "a" : { "x" : 1198, "y" : 323 }, "b" : { "x" : 1210, "y" : 335 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1204, "y" : 329 } }, "inputs" : [ { "id" : 94196 } ], "outputs" : [ { "id" : 94345 } ] }, { "id" : 94218, "reactomeId" : 10637622, "displayName" : "CDC42 GDIs block activation of CDC42", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1459, "y" : 198 }, "minX" : 1453, "maxX" : 1469, "minY" : 174, "maxY" : 236, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1469, "y" : 174 }, "to" : { "x" : 1459, "y" : 198 } }, { "from" : { "x" : 1459, "y" : 198 }, "to" : { "x" : 1461, "y" : 236 } } ], "endShape" : { "a" : { "x" : 1457, "y" : 229 }, "b" : { "x" : 1461, "y" : 236 }, "c" : { "x" : 1465, "y" : 229 }, "type" : "ARROW", "centre" : { "x" : 1465, "y" : 229 } }, "reactionShape" : { "c" : { "x" : 1459, "y" : 198 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1459, "y" : 198 } }, "inputs" : [ { "id" : 94219, "points" : [ { "x" : 1422, "y" : 147 } ] }, { "id" : 94209, "points" : [ { "x" : 1557, "y" : 78 } ] } ], "outputs" : [ { "id" : 94220 } ] }, { "id" : 94346, "reactomeId" : 10640334, "displayName" : "RAC1 binds effectors at the ER membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 893, "y" : 457 }, "minX" : 887, "maxX" : 932, "minY" : 417, "maxY" : 463, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 896, "y" : 417 }, "to" : { "x" : 893, "y" : 457 } }, { "from" : { "x" : 893, "y" : 457 }, "to" : { "x" : 932, "y" : 463 } } ], "endShape" : { "a" : { "x" : 925, "y" : 466 }, "b" : { "x" : 932, "y" : 463 }, "c" : { "x" : 926, "y" : 458 }, "type" : "ARROW", "centre" : { "x" : 926, "y" : 458 } }, "reactionShape" : { "c" : { "x" : 893, "y" : 457 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 893, "y" : 457 } }, "inputs" : [ { "id" : 94345, "points" : [ { "x" : 943, "y" : 419 } ] }, { "id" : 94347, "points" : [ { "x" : 943, "y" : 389 } ] } ], "outputs" : [ { "id" : 94348 } ] }, { "id" : 94221, "reactomeId" : 10637614, "displayName" : "CDC42 binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1944, "y" : 174 }, "minX" : 1938, "maxX" : 1950, "minY" : 138, "maxY" : 264, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1942, "y" : 138 }, "to" : { "x" : 1944, "y" : 174 } }, { "from" : { "x" : 1944, "y" : 174 }, "to" : { "x" : 1946, "y" : 264 } } ], "endShape" : { "a" : { "x" : 1942, "y" : 257 }, "b" : { "x" : 1946, "y" : 264 }, "c" : { "x" : 1950, "y" : 257 }, "type" : "ARROW", "centre" : { "x" : 1950, "y" : 257 } }, "reactionShape" : { "c" : { "x" : 1944, "y" : 174 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1944, "y" : 174 } }, "inputs" : [ { "id" : 94211, "points" : [ { "x" : 1858, "y" : 78 } ] }, { "id" : 94222, "points" : [ { "x" : 1976, "y" : 154 } ] } ], "outputs" : [ { "id" : 94223 } ] }, { "id" : 94349, "reactomeId" : 10640353, "displayName" : "CDC42 translocates to the endoplasmic reticulum membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1856, "y" : 316 }, "minX" : 1011, "maxX" : 1862, "minY" : 78, "maxY" : 517, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1843, "y" : 78 }, "to" : { "x" : 1856, "y" : 316 } }, { "from" : { "x" : 1856, "y" : 316 }, "to" : { "x" : 1011, "y" : 517 } } ], "endShape" : { "a" : { "x" : 1017, "y" : 512 }, "b" : { "x" : 1011, "y" : 517 }, "c" : { "x" : 1019, "y" : 519 }, "type" : "ARROW", "centre" : { "x" : 1019, "y" : 519 } }, "reactionShape" : { "a" : { "x" : 1850, "y" : 310 }, "b" : { "x" : 1862, "y" : 322 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1856, "y" : 316 } }, "inputs" : [ { "id" : 94211 } ], "outputs" : [ { "id" : 94350 } ] }, { "id" : 94351, "reactomeId" : 10640359, "displayName" : "CDC42 binds effectors at the ER membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 852, "y" : 520 }, "minX" : 844, "maxX" : 928, "minY" : 458, "maxY" : 584, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 844, "y" : 458 }, "to" : { "x" : 852, "y" : 520 } }, { "from" : { "x" : 852, "y" : 520 }, "to" : { "x" : 928, "y" : 584 } } ], "endShape" : { "a" : { "x" : 920, "y" : 583 }, "b" : { "x" : 928, "y" : 584 }, "c" : { "x" : 925, "y" : 576 }, "type" : "ARROW", "centre" : { "x" : 925, "y" : 576 } }, "reactionShape" : { "c" : { "x" : 852, "y" : 520 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 852, "y" : 520 } }, "inputs" : [ { "id" : 94352, "points" : [ { "x" : 831, "y" : 396 } ] }, { "id" : 94350, "points" : [ { "x" : 947, "y" : 513 } ] } ], "outputs" : [ { "id" : 94353 } ] }, { "id" : 94224, "reactomeId" : 10637800, "displayName" : "RHOJ GEFs activate RHOJ", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3161, "y" : 1034 }, "minX" : 3155, "maxX" : 3167, "minY" : 1005, "maxY" : 1079, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3161, "y" : 1005 }, "to" : { "x" : 3161, "y" : 1034 } }, { "from" : { "x" : 3161, "y" : 1034 }, "to" : { "x" : 3161, "y" : 1079 } } ], "reactionShape" : { "a" : { "x" : 3155, "y" : 1028 }, "b" : { "x" : 3167, "y" : 1040 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3161, "y" : 1034 } }, "inputs" : [ { "id" : 94225, "points" : [ { "x" : 3161, "y" : 967 } ] }, { "id" : 94226, "points" : [ { "x" : 3118, "y" : 990 } ] } ], "outputs" : [ { "id" : 94227, "points" : [ { "x" : 3158, "y" : 1121 } ] }, { "id" : 94228, "points" : [ { "x" : 3122, "y" : 1084 } ] } ], "catalysts" : [ { "id" : 94229, "points" : [ { "x" : 3117, "y" : 1035 } ] } ] }, { "id" : 94354, "reactomeId" : 10640376, "displayName" : "RHOF auto-activates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3186, "y" : 715 }, "minX" : 3180, "maxX" : 3193, "minY" : 684, "maxY" : 751, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3188, "y" : 684 }, "to" : { "x" : 3186, "y" : 715 } }, { "from" : { "x" : 3186, "y" : 715 }, "to" : { "x" : 3193, "y" : 751 } } ], "reactionShape" : { "a" : { "x" : 3180, "y" : 709 }, "b" : { "x" : 3192, "y" : 721 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3186, "y" : 715 } }, "inputs" : [ { "id" : 94355, "points" : [ { "x" : 3188, "y" : 660 } ] }, { "id" : 94356, "points" : [ { "x" : 3132, "y" : 679 } ] } ], "outputs" : [ { "id" : 94357, "points" : [ { "x" : 3186, "y" : 776 } ] }, { "id" : 94358, "points" : [ { "x" : 3129, "y" : 747 } ] } ], "catalysts" : [ { "id" : 94355, "points" : [ { "x" : 3199, "y" : 660 }, { "x" : 3226, "y" : 685 } ] } ] }, { "id" : 94359, "reactomeId" : 10640433, "displayName" : "RHOF GAPs stimulate RHOF GTPase activity", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3054, "y" : 712 }, "minX" : 3048, "maxX" : 3060, "minY" : 645, "maxY" : 763, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3052, "y" : 763 }, "to" : { "x" : 3054, "y" : 712 } }, { "from" : { "x" : 3054, "y" : 712 }, "to" : { "x" : 3052, "y" : 645 } } ], "reactionShape" : { "a" : { "x" : 3048, "y" : 706 }, "b" : { "x" : 3060, "y" : 718 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3054, "y" : 712 } }, "inputs" : [ { "id" : 94357, "points" : [ { "x" : 3145, "y" : 782 } ] }, { "id" : 94360, "points" : [ { "x" : 3028, "y" : 772 } ] } ], "outputs" : [ { "id" : 94355, "points" : [ { "x" : 3148, "y" : 645 } ] }, { "id" : 94361, "points" : [ { "x" : 3025, "y" : 638 } ] } ], "catalysts" : [ { "id" : 94362, "points" : [ { "x" : 3019, "y" : 712 } ] } ] }, { "id" : 94230, "reactomeId" : 10637795, "displayName" : "RHOJ GAPs stimulate RHOJ GTPase activity", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2996, "y" : 1032 }, "minX" : 2990, "maxX" : 3002, "minY" : 969, "maxY" : 1099, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2998, "y" : 1099 }, "to" : { "x" : 2996, "y" : 1032 } }, { "from" : { "x" : 2996, "y" : 1032 }, "to" : { "x" : 2998, "y" : 969 } } ], "reactionShape" : { "a" : { "x" : 2990, "y" : 1026 }, "b" : { "x" : 3002, "y" : 1038 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2996, "y" : 1032 } }, "inputs" : [ { "id" : 94227, "points" : [ { "x" : 3119, "y" : 1127 } ] }, { "id" : 94231, "points" : [ { "x" : 2963, "y" : 1115 } ] } ], "outputs" : [ { "id" : 94225, "points" : [ { "x" : 3121, "y" : 955 } ] }, { "id" : 94232, "points" : [ { "x" : 2967, "y" : 959 } ] } ], "catalysts" : [ { "id" : 94233, "points" : [ { "x" : 2927, "y" : 1031 } ] } ] }, { "id" : 94363, "reactomeId" : 10640422, "displayName" : "RHOF binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3124, "y" : 825 }, "minX" : 3086, "maxX" : 3166, "minY" : 800, "maxY" : 857, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3086, "y" : 800 }, "to" : { "x" : 3124, "y" : 825 } }, { "from" : { "x" : 3124, "y" : 825 }, "to" : { "x" : 3166, "y" : 857 } } ], "endShape" : { "a" : { "x" : 3158, "y" : 856 }, "b" : { "x" : 3166, "y" : 857 }, "c" : { "x" : 3163, "y" : 850 }, "type" : "ARROW", "centre" : { "x" : 3163, "y" : 850 } }, "reactionShape" : { "c" : { "x" : 3124, "y" : 825 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3124, "y" : 825 } }, "inputs" : [ { "id" : 94364, "points" : [ { "x" : 3003, "y" : 818 } ] }, { "id" : 94357, "points" : [ { "x" : 3145, "y" : 793 } ] } ], "outputs" : [ { "id" : 94365 } ] }, { "id" : 94234, "reactomeId" : 10637852, "displayName" : "RHOQ GEFs activate RHOQ", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3159, "y" : 1467 }, "minX" : 3153, "maxX" : 3165, "minY" : 1421, "maxY" : 1513, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3158, "y" : 1421 }, "to" : { "x" : 3159, "y" : 1467 } }, { "from" : { "x" : 3159, "y" : 1467 }, "to" : { "x" : 3158, "y" : 1513 } } ], "reactionShape" : { "a" : { "x" : 3153, "y" : 1461 }, "b" : { "x" : 3165, "y" : 1473 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3159, "y" : 1467 } }, "inputs" : [ { "id" : 94235, "points" : [ { "x" : 3156, "y" : 1352 } ] }, { "id" : 94236, "points" : [ { "x" : 3117, "y" : 1414 } ] } ], "outputs" : [ { "id" : 94237, "points" : [ { "x" : 3158, "y" : 1556 } ] }, { "id" : 94238, "points" : [ { "x" : 3107, "y" : 1522 } ] } ], "catalysts" : [ { "id" : 94239, "points" : [ { "x" : 3084, "y" : 1463 } ] } ] }, { "id" : 94366, "reactomeId" : 10637862, "displayName" : "GDIs bind RHOH", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3057, "y" : 1965 }, "minX" : 3005, "maxX" : 3111, "minY" : 1946, "maxY" : 1996, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3111, "y" : 1996 }, "to" : { "x" : 3057, "y" : 1965 } }, { "from" : { "x" : 3057, "y" : 1965 }, "to" : { "x" : 3005, "y" : 1946 } } ], "endShape" : { "a" : { "x" : 3013, "y" : 1945 }, "b" : { "x" : 3005, "y" : 1946 }, "c" : { "x" : 3010, "y" : 1952 }, "type" : "ARROW", "centre" : { "x" : 3010, "y" : 1952 } }, "reactionShape" : { "c" : { "x" : 3057, "y" : 1965 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3057, "y" : 1965 } }, "inputs" : [ { "id" : 94255, "points" : [ { "x" : 3165, "y" : 2028 } ] }, { "id" : 94367, "points" : [ { "x" : 3048, "y" : 2013 } ] } ], "outputs" : [ { "id" : 94368 } ] }, { "id" : 94369, "reactomeId" : 10640552, "displayName" : "RND1 binds GTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1818, "y" : 2412 }, "minX" : 1788, "maxX" : 1858, "minY" : 2406, "maxY" : 2418, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1788, "y" : 2410 }, "to" : { "x" : 1818, "y" : 2412 } }, { "from" : { "x" : 1818, "y" : 2412 }, "to" : { "x" : 1858, "y" : 2411 } } ], "endShape" : { "a" : { "x" : 1851, "y" : 2415 }, "b" : { "x" : 1858, "y" : 2411 }, "c" : { "x" : 1851, "y" : 2407 }, "type" : "ARROW", "centre" : { "x" : 1851, "y" : 2407 } }, "reactionShape" : { "c" : { "x" : 1818, "y" : 2412 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1818, "y" : 2412 } }, "inputs" : [ { "id" : 94370, "points" : [ { "x" : 1766, "y" : 2412 } ] }, { "id" : 94371, "points" : [ { "x" : 1777, "y" : 2384 } ] } ], "outputs" : [ { "id" : 94372 } ] }, { "id" : 94240, "reactomeId" : 10637831, "displayName" : "RHOQ GAPs stimulate RHOQ GTPase activity", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2974, "y" : 1471 }, "minX" : 2968, "maxX" : 2980, "minY" : 1360, "maxY" : 1561, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2980, "y" : 1561 }, "to" : { "x" : 2974, "y" : 1471 } }, { "from" : { "x" : 2974, "y" : 1471 }, "to" : { "x" : 2976, "y" : 1360 } } ], "reactionShape" : { "a" : { "x" : 2968, "y" : 1465 }, "b" : { "x" : 2980, "y" : 1477 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2974, "y" : 1471 } }, "inputs" : [ { "id" : 94241, "points" : [ { "x" : 2910, "y" : 1558 } ] }, { "id" : 94237, "points" : [ { "x" : 3120, "y" : 1568 } ] } ], "outputs" : [ { "id" : 94235, "points" : [ { "x" : 3117, "y" : 1342 } ] }, { "id" : 94242, "points" : [ { "x" : 2929, "y" : 1344 } ] } ], "catalysts" : [ { "id" : 94243, "points" : [ { "x" : 2915, "y" : 1469 } ] } ] }, { "id" : 94373, "reactomeId" : 10640550, "displayName" : "RND1 binds effectors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1989, "y" : 2412 }, "minX" : 1965, "maxX" : 2036, "minY" : 2406, "maxY" : 2418, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1965, "y" : 2414 }, "to" : { "x" : 1989, "y" : 2412 } }, { "from" : { "x" : 1989, "y" : 2412 }, "to" : { "x" : 2036, "y" : 2413 } } ], "endShape" : { "a" : { "x" : 2029, "y" : 2417 }, "b" : { "x" : 2036, "y" : 2413 }, "c" : { "x" : 2029, "y" : 2409 }, "type" : "ARROW", "centre" : { "x" : 2029, "y" : 2409 } }, "reactionShape" : { "c" : { "x" : 1989, "y" : 2412 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1989, "y" : 2412 } }, "inputs" : [ { "id" : 94372, "points" : [ { "x" : 1937, "y" : 2412 } ] }, { "id" : 94374, "points" : [ { "x" : 1936, "y" : 2369 } ] } ], "outputs" : [ { "id" : 94375 } ] }, { "id" : 94244, "reactomeId" : 10637847, "displayName" : "RHOQ binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3139, "y" : 1697 }, "minX" : 3133, "maxX" : 3165, "minY" : 1653, "maxY" : 1755, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3137, "y" : 1653 }, "to" : { "x" : 3139, "y" : 1697 } }, { "from" : { "x" : 3139, "y" : 1697 }, "to" : { "x" : 3165, "y" : 1755 } } ], "endShape" : { "a" : { "x" : 3159, "y" : 1750 }, "b" : { "x" : 3165, "y" : 1755 }, "c" : { "x" : 3166, "y" : 1747 }, "type" : "ARROW", "centre" : { "x" : 3166, "y" : 1747 } }, "reactionShape" : { "c" : { "x" : 3139, "y" : 1697 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3139, "y" : 1697 } }, "inputs" : [ { "id" : 94237, "points" : [ { "x" : 3156, "y" : 1584 } ] }, { "id" : 94245, "points" : [ { "x" : 3072, "y" : 1615 } ] } ], "outputs" : [ { "id" : 94246 } ] }, { "id" : 94247, "reactomeId" : 10638045, "displayName" : "RHOQ translocates to the Golgi-associated vesicle membranes", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2790, "y" : 1583 }, "minX" : 2701, "maxX" : 3120, "minY" : 1505, "maxY" : 1589, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3120, "y" : 1571 }, "to" : { "x" : 2790, "y" : 1583 } }, { "from" : { "x" : 2790, "y" : 1583 }, "to" : { "x" : 2701, "y" : 1505 } } ], "endShape" : { "a" : { "x" : 2709, "y" : 1507 }, "b" : { "x" : 2701, "y" : 1505 }, "c" : { "x" : 2704, "y" : 1513 }, "type" : "ARROW", "centre" : { "x" : 2704, "y" : 1513 } }, "reactionShape" : { "a" : { "x" : 2784, "y" : 1577 }, "b" : { "x" : 2796, "y" : 1589 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2790, "y" : 1583 } }, "inputs" : [ { "id" : 94237 } ], "outputs" : [ { "id" : 94248 } ] }, { "id" : 94249, "reactomeId" : 10613984, "displayName" : "RHOQ binds GOPC:CFTR", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2637, "y" : 1431 }, "minX" : 2597, "maxX" : 2667, "minY" : 1405, "maxY" : 1449, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2597, "y" : 1449 }, "to" : { "x" : 2637, "y" : 1431 } }, { "from" : { "x" : 2637, "y" : 1431 }, "to" : { "x" : 2667, "y" : 1405 } } ], "endShape" : { "a" : { "x" : 2664, "y" : 1413 }, "b" : { "x" : 2667, "y" : 1405 }, "c" : { "x" : 2659, "y" : 1407 }, "type" : "ARROW", "centre" : { "x" : 2659, "y" : 1407 } }, "reactionShape" : { "c" : { "x" : 2637, "y" : 1431 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2637, "y" : 1431 } }, "inputs" : [ { "id" : 94250, "points" : [ { "x" : 2574, "y" : 1412 } ] }, { "id" : 94248, "points" : [ { "x" : 2664, "y" : 1477 } ] } ], "outputs" : [ { "id" : 94251 } ] }, { "id" : 94376, "reactomeId" : 10640554, "displayName" : "RND2 binds GTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2278, "y" : 2414 }, "minX" : 2250, "maxX" : 2316, "minY" : 2408, "maxY" : 2420, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2250, "y" : 2413 }, "to" : { "x" : 2278, "y" : 2414 } }, { "from" : { "x" : 2278, "y" : 2414 }, "to" : { "x" : 2316, "y" : 2414 } } ], "endShape" : { "a" : { "x" : 2309, "y" : 2418 }, "b" : { "x" : 2316, "y" : 2414 }, "c" : { "x" : 2309, "y" : 2410 }, "type" : "ARROW", "centre" : { "x" : 2309, "y" : 2410 } }, "reactionShape" : { "c" : { "x" : 2278, "y" : 2414 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2278, "y" : 2414 } }, "inputs" : [ { "id" : 94377, "points" : [ { "x" : 2222, "y" : 2413 } ] }, { "id" : 94378, "points" : [ { "x" : 2235, "y" : 2376 } ] } ], "outputs" : [ { "id" : 94379 } ] }, { "id" : 94252, "reactomeId" : 10637864, "displayName" : "RHOH binds GTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3181, "y" : 1972 }, "minX" : 3175, "maxX" : 3187, "minY" : 1932, "maxY" : 2028, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3178, "y" : 1932 }, "to" : { "x" : 3181, "y" : 1972 } }, { "from" : { "x" : 3181, "y" : 1972 }, "to" : { "x" : 3182, "y" : 2028 } } ], "endShape" : { "a" : { "x" : 3178, "y" : 2021 }, "b" : { "x" : 3182, "y" : 2028 }, "c" : { "x" : 3186, "y" : 2021 }, "type" : "ARROW", "centre" : { "x" : 3186, "y" : 2021 } }, "reactionShape" : { "c" : { "x" : 3181, "y" : 1972 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3181, "y" : 1972 } }, "inputs" : [ { "id" : 94253, "points" : [ { "x" : 3176, "y" : 1900 } ] }, { "id" : 94254, "points" : [ { "x" : 3138, "y" : 1936 } ] } ], "outputs" : [ { "id" : 94255 } ] }, { "id" : 94380, "reactomeId" : 10640510, "displayName" : "RND2 binds effectors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2465, "y" : 2412 }, "minX" : 2432, "maxX" : 2502, "minY" : 2406, "maxY" : 2418, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2432, "y" : 2410 }, "to" : { "x" : 2465, "y" : 2412 } }, { "from" : { "x" : 2465, "y" : 2412 }, "to" : { "x" : 2502, "y" : 2412 } } ], "endShape" : { "a" : { "x" : 2495, "y" : 2416 }, "b" : { "x" : 2502, "y" : 2412 }, "c" : { "x" : 2495, "y" : 2408 }, "type" : "ARROW", "centre" : { "x" : 2495, "y" : 2408 } }, "reactionShape" : { "c" : { "x" : 2465, "y" : 2412 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2465, "y" : 2412 } }, "inputs" : [ { "id" : 94379, "points" : [ { "x" : 2399, "y" : 2411 } ] }, { "id" : 94381, "points" : [ { "x" : 2421, "y" : 2376 } ] } ], "outputs" : [ { "id" : 94382 } ] }, { "id" : 94383, "reactomeId" : 10640518, "displayName" : "RND3 binds GTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2765, "y" : 2413 }, "minX" : 2732, "maxX" : 2811, "minY" : 2407, "maxY" : 2419, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2732, "y" : 2413 }, "to" : { "x" : 2765, "y" : 2413 } }, { "from" : { "x" : 2765, "y" : 2413 }, "to" : { "x" : 2811, "y" : 2412 } } ], "endShape" : { "a" : { "x" : 2804, "y" : 2416 }, "b" : { "x" : 2811, "y" : 2412 }, "c" : { "x" : 2804, "y" : 2408 }, "type" : "ARROW", "centre" : { "x" : 2804, "y" : 2408 } }, "reactionShape" : { "c" : { "x" : 2765, "y" : 2413 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2765, "y" : 2413 } }, "inputs" : [ { "id" : 94384, "points" : [ { "x" : 2699, "y" : 2413 } ] }, { "id" : 94385, "points" : [ { "x" : 2720, "y" : 2378 } ] } ], "outputs" : [ { "id" : 94386 } ] }, { "id" : 94256, "reactomeId" : 10637892, "displayName" : "RHOH binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3184, "y" : 2147 }, "minX" : 3178, "maxX" : 3190, "minY" : 2105, "maxY" : 2193, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3185, "y" : 2105 }, "to" : { "x" : 3184, "y" : 2147 } }, { "from" : { "x" : 3184, "y" : 2147 }, "to" : { "x" : 3184, "y" : 2193 } } ], "endShape" : { "a" : { "x" : 3180, "y" : 2186 }, "b" : { "x" : 3184, "y" : 2193 }, "c" : { "x" : 3188, "y" : 2186 }, "type" : "ARROW", "centre" : { "x" : 3188, "y" : 2186 } }, "reactionShape" : { "c" : { "x" : 3184, "y" : 2147 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3184, "y" : 2147 } }, "inputs" : [ { "id" : 94257, "points" : [ { "x" : 3147, "y" : 2101 } ] }, { "id" : 94255, "points" : [ { "x" : 3183, "y" : 2056 } ] } ], "outputs" : [ { "id" : 94258 } ] }, { "id" : 94387, "reactomeId" : 10640532, "displayName" : "RND3 binds effectors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2986, "y" : 2411 }, "minX" : 2935, "maxX" : 3029, "minY" : 2405, "maxY" : 2417, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2935, "y" : 2414 }, "to" : { "x" : 2986, "y" : 2411 } }, { "from" : { "x" : 2986, "y" : 2411 }, "to" : { "x" : 3029, "y" : 2411 } } ], "endShape" : { "a" : { "x" : 3022, "y" : 2415 }, "b" : { "x" : 3029, "y" : 2411 }, "c" : { "x" : 3022, "y" : 2407 }, "type" : "ARROW", "centre" : { "x" : 3022, "y" : 2407 } }, "reactionShape" : { "c" : { "x" : 2986, "y" : 2411 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2986, "y" : 2411 } }, "inputs" : [ { "id" : 94386, "points" : [ { "x" : 2894, "y" : 2412 } ] }, { "id" : 94388, "points" : [ { "x" : 2918, "y" : 2362 } ] } ], "outputs" : [ { "id" : 94389 } ] }, { "id" : 94259, "reactomeId" : 10637925, "displayName" : "RHOU auto-activates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1244, "y" : 2409 }, "minX" : 1197, "maxX" : 1290, "minY" : 2403, "maxY" : 2415, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1290, "y" : 2410 }, "to" : { "x" : 1244, "y" : 2409 } }, { "from" : { "x" : 1244, "y" : 2409 }, "to" : { "x" : 1197, "y" : 2410 } } ], "reactionShape" : { "a" : { "x" : 1238, "y" : 2403 }, "b" : { "x" : 1250, "y" : 2415 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1244, "y" : 2409 } }, "inputs" : [ { "id" : 94260, "points" : [ { "x" : 1372, "y" : 2411 } ] }, { "id" : 94261, "points" : [ { "x" : 1304, "y" : 2389 } ] } ], "outputs" : [ { "id" : 94262, "points" : [ { "x" : 1151, "y" : 2410 } ] }, { "id" : 94263, "points" : [ { "x" : 1171, "y" : 2374 } ] } ], "catalysts" : [ { "id" : 94260, "points" : [ { "x" : 1372, "y" : 2419 }, { "x" : 1258, "y" : 2445 } ] } ] }, { "id" : 94390, "reactomeId" : 10641116, "displayName" : "RAC2 translocates to the ER membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2828, "y" : 269 }, "minX" : 925, "maxX" : 2834, "minY" : 81, "maxY" : 1063, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2775, "y" : 81 }, "to" : { "x" : 2828, "y" : 269 } }, { "from" : { "x" : 2828, "y" : 269 }, "to" : { "x" : 2637, "y" : 505 } }, { "from" : { "x" : 2637, "y" : 505 }, "to" : { "x" : 2765, "y" : 1053 } }, { "from" : { "x" : 2765, "y" : 1053 }, "to" : { "x" : 1084, "y" : 1063 } }, { "from" : { "x" : 1084, "y" : 1063 }, "to" : { "x" : 925, "y" : 818 } } ], "endShape" : { "a" : { "x" : 932, "y" : 822 }, "b" : { "x" : 925, "y" : 818 }, "c" : { "x" : 925, "y" : 826 }, "type" : "ARROW", "centre" : { "x" : 925, "y" : 826 } }, "reactionShape" : { "a" : { "x" : 2822, "y" : 263 }, "b" : { "x" : 2834, "y" : 275 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2828, "y" : 269 } }, "inputs" : [ { "id" : 94270 } ], "outputs" : [ { "id" : 94391 } ] }, { "id" : 94264, "reactomeId" : 10637920, "displayName" : "RHOU binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1030, "y" : 2371 }, "minX" : 1009, "maxX" : 1063, "minY" : 2347, "maxY" : 2398, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1063, "y" : 2347 }, "to" : { "x" : 1030, "y" : 2371 } }, { "from" : { "x" : 1030, "y" : 2371 }, "to" : { "x" : 1009, "y" : 2398 } } ], "endShape" : { "a" : { "x" : 1010, "y" : 2390 }, "b" : { "x" : 1009, "y" : 2398 }, "c" : { "x" : 1016, "y" : 2395 }, "type" : "ARROW", "centre" : { "x" : 1016, "y" : 2395 } }, "reactionShape" : { "c" : { "x" : 1030, "y" : 2371 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1030, "y" : 2371 } }, "inputs" : [ { "id" : 94265, "points" : [ { "x" : 1050, "y" : 2318 } ] }, { "id" : 94262, "points" : [ { "x" : 1103, "y" : 2397 } ] } ], "outputs" : [ { "id" : 94266 } ] }, { "id" : 94392, "reactomeId" : 10641110, "displayName" : "RAC2 translocates to the mitochondrial membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2805, "y" : 272 }, "minX" : 2147, "maxX" : 2811, "minY" : 81, "maxY" : 655, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2774, "y" : 81 }, "to" : { "x" : 2805, "y" : 272 } }, { "from" : { "x" : 2805, "y" : 272 }, "to" : { "x" : 2587, "y" : 463 } }, { "from" : { "x" : 2587, "y" : 463 }, "to" : { "x" : 2561, "y" : 655 } }, { "from" : { "x" : 2561, "y" : 655 }, "to" : { "x" : 2147, "y" : 565 } } ], "endShape" : { "a" : { "x" : 2155, "y" : 563 }, "b" : { "x" : 2147, "y" : 565 }, "c" : { "x" : 2153, "y" : 570 }, "type" : "ARROW", "centre" : { "x" : 2153, "y" : 570 } }, "reactionShape" : { "a" : { "x" : 2799, "y" : 266 }, "b" : { "x" : 2811, "y" : 278 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2805, "y" : 272 } }, "inputs" : [ { "id" : 94270 } ], "outputs" : [ { "id" : 94393 } ] }, { "id" : 94267, "reactomeId" : 10637695, "displayName" : "RAC2 GEFs activate RAC2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2677, "y" : 71 }, "minX" : 2645, "maxX" : 2708, "minY" : 65, "maxY" : 77, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2645, "y" : 68 }, "to" : { "x" : 2677, "y" : 71 } }, { "from" : { "x" : 2677, "y" : 71 }, "to" : { "x" : 2708, "y" : 69 } } ], "reactionShape" : { "a" : { "x" : 2671, "y" : 65 }, "b" : { "x" : 2683, "y" : 77 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2677, "y" : 71 } }, "inputs" : [ { "id" : 94268, "points" : [ { "x" : 2608, "y" : 63 } ] }, { "id" : 94269, "points" : [ { "x" : 2623, "y" : 101 } ] } ], "outputs" : [ { "id" : 94270, "points" : [ { "x" : 2736, "y" : 68 } ] }, { "id" : 94271, "points" : [ { "x" : 2727, "y" : 100 } ] } ], "catalysts" : [ { "id" : 94272, "points" : [ { "x" : 2677, "y" : 156 } ] } ] }, { "id" : 94394, "reactomeId" : 10641108, "displayName" : "RAC2 binds effectors at the mitochondrial outer membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1989, "y" : 618 }, "minX" : 1932, "maxX" : 2014, "minY" : 590, "maxY" : 630, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2014, "y" : 590 }, "to" : { "x" : 1989, "y" : 618 } }, { "from" : { "x" : 1989, "y" : 618 }, "to" : { "x" : 1932, "y" : 630 } } ], "endShape" : { "a" : { "x" : 1938, "y" : 625 }, "b" : { "x" : 1932, "y" : 630 }, "c" : { "x" : 1940, "y" : 632 }, "type" : "ARROW", "centre" : { "x" : 1940, "y" : 632 } }, "reactionShape" : { "a" : { "x" : 1983, "y" : 612 }, "b" : { "x" : 1995, "y" : 624 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1989, "y" : 618 } }, "inputs" : [ { "id" : 94393, "points" : [ { "x" : 2076, "y" : 572 } ] }, { "id" : 94395, "points" : [ { "x" : 1797, "y" : 593 } ] } ], "outputs" : [ { "id" : 94396 } ] }, { "id" : 94397, "reactomeId" : 10641130, "displayName" : "RAC3 translocates to the endoplasmic reticulum membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2798, "y" : 994 }, "minX" : 1075, "maxX" : 3145, "minY" : 509, "maxY" : 1000, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 3145, "y" : 509 }, "to" : { "x" : 2791, "y" : 600 } }, { "from" : { "x" : 2791, "y" : 600 }, "to" : { "x" : 2798, "y" : 994 } }, { "from" : { "x" : 2798, "y" : 994 }, "to" : { "x" : 1704, "y" : 988 } }, { "from" : { "x" : 1704, "y" : 988 }, "to" : { "x" : 1075, "y" : 822 } } ], "endShape" : { "a" : { "x" : 1083, "y" : 820 }, "b" : { "x" : 1075, "y" : 822 }, "c" : { "x" : 1081, "y" : 828 }, "type" : "ARROW", "centre" : { "x" : 1081, "y" : 828 } }, "reactionShape" : { "a" : { "x" : 2792, "y" : 988 }, "b" : { "x" : 2804, "y" : 1000 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2798, "y" : 994 } }, "inputs" : [ { "id" : 94326 } ], "outputs" : [ { "id" : 94398 } ] }, { "id" : 94140, "reactomeId" : 10636276, "displayName" : "RHOA GEFs activate RHOA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 525, "y" : 65 }, "minX" : 484, "maxX" : 564, "minY" : 59, "maxY" : 71, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 484, "y" : 62 }, "to" : { "x" : 525, "y" : 65 } }, { "from" : { "x" : 525, "y" : 65 }, "to" : { "x" : 564, "y" : 64 } } ], "reactionShape" : { "a" : { "x" : 519, "y" : 59 }, "b" : { "x" : 531, "y" : 71 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 525, "y" : 65 } }, "inputs" : [ { "id" : 94141, "points" : [ { "x" : 454, "y" : 85 } ] }, { "id" : 94142, "points" : [ { "x" : 419, "y" : 63 } ] } ], "outputs" : [ { "id" : 94143, "points" : [ { "x" : 578, "y" : 98 } ] }, { "id" : 94144, "points" : [ { "x" : 605, "y" : 64 } ] } ], "catalysts" : [ { "id" : 94145, "points" : [ { "x" : 524, "y" : 136 } ] } ] }, { "id" : 94399, "reactomeId" : 10641082, "displayName" : "RHOC translocates to the endoplasmic reticulum membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 358, "y" : 1673 }, "minX" : 92, "maxX" : 637, "minY" : 890, "maxY" : 1679, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 92, "y" : 1622 }, "to" : { "x" : 358, "y" : 1673 } }, { "from" : { "x" : 358, "y" : 1673 }, "to" : { "x" : 591, "y" : 1395 } }, { "from" : { "x" : 591, "y" : 1395 }, "to" : { "x" : 637, "y" : 890 } } ], "endShape" : { "a" : { "x" : 640, "y" : 897 }, "b" : { "x" : 637, "y" : 890 }, "c" : { "x" : 632, "y" : 897 }, "type" : "ARROW", "centre" : { "x" : 632, "y" : 897 } }, "reactionShape" : { "a" : { "x" : 352, "y" : 1667 }, "b" : { "x" : 364, "y" : 1679 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 358, "y" : 1673 } }, "inputs" : [ { "id" : 94180 } ], "outputs" : [ { "id" : 94400 } ] }, { "id" : 94273, "reactomeId" : 10637690, "displayName" : "RAC2 GAPs stimulate RAC2 GTPase activity", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2686, "y" : 221 }, "minX" : 2588, "maxX" : 2773, "minY" : 202, "maxY" : 227, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2773, "y" : 202 }, "to" : { "x" : 2686, "y" : 221 } }, { "from" : { "x" : 2686, "y" : 221 }, "to" : { "x" : 2588, "y" : 216 } } ], "reactionShape" : { "a" : { "x" : 2680, "y" : 215 }, "b" : { "x" : 2692, "y" : 227 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2686, "y" : 221 } }, "inputs" : [ { "id" : 94274, "points" : [ { "x" : 2770, "y" : 246 } ] }, { "id" : 94270, "points" : [ { "x" : 2773, "y" : 81 } ] } ], "outputs" : [ { "id" : 94268, "points" : [ { "x" : 2571, "y" : 73 } ] }, { "id" : 94275, "points" : [ { "x" : 2562, "y" : 241 } ] } ], "catalysts" : [ { "id" : 94276, "points" : [ { "x" : 2685, "y" : 290 } ] } ] }, { "id" : 94401, "reactomeId" : 10641245, "displayName" : "Phosphorylated RHOU translocates to the endosome membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1673, "y" : 2151 }, "minX" : 959, "maxX" : 1679, "minY" : 2075, "maxY" : 2394, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1657, "y" : 2394 }, "to" : { "x" : 1673, "y" : 2151 } }, { "from" : { "x" : 1673, "y" : 2151 }, "to" : { "x" : 959, "y" : 2075 } } ], "endShape" : { "a" : { "x" : 966, "y" : 2072 }, "b" : { "x" : 959, "y" : 2075 }, "c" : { "x" : 965, "y" : 2080 }, "type" : "ARROW", "centre" : { "x" : 965, "y" : 2080 } }, "reactionShape" : { "a" : { "x" : 1667, "y" : 2145 }, "b" : { "x" : 1679, "y" : 2157 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1673, "y" : 2151 } }, "inputs" : [ { "id" : 94402 } ], "outputs" : [ { "id" : 94403 } ] }, { "id" : 94146, "reactomeId" : 10636421, "displayName" : "RHOA GAPs stimulate RHOA GTPase activity", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 526, "y" : 216 }, "minX" : 421, "maxX" : 592, "minY" : 210, "maxY" : 222, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 592, "y" : 212 }, "to" : { "x" : 526, "y" : 216 } }, { "from" : { "x" : 526, "y" : 216 }, "to" : { "x" : 421, "y" : 211 } } ], "reactionShape" : { "a" : { "x" : 520, "y" : 210 }, "b" : { "x" : 532, "y" : 222 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 526, "y" : 216 } }, "inputs" : [ { "id" : 94147, "points" : [ { "x" : 604, "y" : 232 } ] }, { "id" : 94144, "points" : [ { "x" : 639, "y" : 79 } ] } ], "outputs" : [ { "id" : 94142, "points" : [ { "x" : 383, "y" : 78 } ] }, { "id" : 94148, "points" : [ { "x" : 407, "y" : 241 } ] } ], "catalysts" : [ { "id" : 94149, "points" : [ { "x" : 525, "y" : 262 } ] } ] }, { "id" : 94277, "reactomeId" : 10637667, "displayName" : "RAC2 GDIs block activation of RAC2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2523, "y" : 154 }, "minX" : 2517, "maxX" : 2543, "minY" : 113, "maxY" : 176, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2543, "y" : 113 }, "to" : { "x" : 2523, "y" : 154 } }, { "from" : { "x" : 2523, "y" : 154 }, "to" : { "x" : 2525, "y" : 176 } } ], "endShape" : { "a" : { "x" : 2520, "y" : 169 }, "b" : { "x" : 2525, "y" : 176 }, "c" : { "x" : 2528, "y" : 169 }, "type" : "ARROW", "centre" : { "x" : 2528, "y" : 169 } }, "reactionShape" : { "c" : { "x" : 2523, "y" : 154 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2523, "y" : 154 } }, "inputs" : [ { "id" : 94278, "points" : [ { "x" : 2511, "y" : 116 } ] }, { "id" : 94268, "points" : [ { "x" : 2564, "y" : 73 } ] } ], "outputs" : [ { "id" : 94279 } ] }, { "id" : 94150, "reactomeId" : 10637320, "displayName" : "GDIs block activation of RHOA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 287, "y" : 174 }, "minX" : 272, "maxX" : 303, "minY" : 114, "maxY" : 239, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 303, "y" : 114 }, "to" : { "x" : 287, "y" : 174 } }, { "from" : { "x" : 287, "y" : 174 }, "to" : { "x" : 272, "y" : 239 } } ], "endShape" : { "a" : { "x" : 270, "y" : 231 }, "b" : { "x" : 272, "y" : 239 }, "c" : { "x" : 277, "y" : 233 }, "type" : "ARROW", "centre" : { "x" : 277, "y" : 233 } }, "reactionShape" : { "c" : { "x" : 287, "y" : 174 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 287, "y" : 174 } }, "inputs" : [ { "id" : 94151, "points" : [ { "x" : 281, "y" : 116 } ] }, { "id" : 94142, "points" : [ { "x" : 363, "y" : 78 } ] } ], "outputs" : [ { "id" : 94152 } ] }, { "id" : 94153, "reactomeId" : 10637398, "displayName" : "RHOA binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 719, "y" : 68 }, "minX" : 698, "maxX" : 749, "minY" : 62, "maxY" : 74, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 698, "y" : 69 }, "to" : { "x" : 719, "y" : 68 } }, { "from" : { "x" : 719, "y" : 68 }, "to" : { "x" : 749, "y" : 65 } } ], "endShape" : { "a" : { "x" : 743, "y" : 70 }, "b" : { "x" : 749, "y" : 65 }, "c" : { "x" : 742, "y" : 62 }, "type" : "ARROW", "centre" : { "x" : 742, "y" : 62 } }, "reactionShape" : { "c" : { "x" : 719, "y" : 68 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 719, "y" : 68 } }, "inputs" : [ { "id" : 94144, "points" : [ { "x" : 682, "y" : 67 } ] }, { "id" : 94154, "points" : [ { "x" : 726, "y" : 127 } ] } ], "outputs" : [ { "id" : 94155 } ] }, { "id" : 94280, "reactomeId" : 10637685, "displayName" : "RAC2 binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2952, "y" : 126 }, "minX" : 2922, "maxX" : 3003, "minY" : 88, "maxY" : 132, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2922, "y" : 128 }, "to" : { "x" : 2952, "y" : 126 } }, { "from" : { "x" : 2952, "y" : 126 }, "to" : { "x" : 3003, "y" : 88 } } ], "endShape" : { "a" : { "x" : 3000, "y" : 95 }, "b" : { "x" : 3003, "y" : 88 }, "c" : { "x" : 2995, "y" : 89 }, "type" : "ARROW", "centre" : { "x" : 2995, "y" : 89 } }, "reactionShape" : { "c" : { "x" : 2952, "y" : 126 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2952, "y" : 126 } }, "inputs" : [ { "id" : 94270, "points" : [ { "x" : 2799, "y" : 81 } ] }, { "id" : 94281, "points" : [ { "x" : 2906, "y" : 153 } ] } ], "outputs" : [ { "id" : 94282 } ] }, { "id" : 94283, "reactomeId" : 10637697, "displayName" : "RAC2 translocates to the phagocytic vesicle membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2857, "y" : 269 }, "minX" : 2765, "maxX" : 2863, "minY" : 81, "maxY" : 417, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2777, "y" : 81 }, "to" : { "x" : 2857, "y" : 269 } }, { "from" : { "x" : 2857, "y" : 269 }, "to" : { "x" : 2765, "y" : 417 } } ], "endShape" : { "a" : { "x" : 2765, "y" : 409 }, "b" : { "x" : 2765, "y" : 417 }, "c" : { "x" : 2772, "y" : 413 }, "type" : "ARROW", "centre" : { "x" : 2772, "y" : 413 } }, "reactionShape" : { "a" : { "x" : 2851, "y" : 263 }, "b" : { "x" : 2863, "y" : 275 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2857, "y" : 269 } }, "inputs" : [ { "id" : 94270 } ], "outputs" : [ { "id" : 94284 } ] }, { "id" : 94285, "reactomeId" : 10637699, "displayName" : "RAC2 binds effectors at the phagocytic vesicle membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2868, "y" : 470 }, "minX" : 2846, "maxX" : 2893, "minY" : 457, "maxY" : 500, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2846, "y" : 457 }, "to" : { "x" : 2868, "y" : 470 } }, { "from" : { "x" : 2868, "y" : 470 }, "to" : { "x" : 2893, "y" : 500 } } ], "endShape" : { "a" : { "x" : 2885, "y" : 497 }, "b" : { "x" : 2893, "y" : 500 }, "c" : { "x" : 2892, "y" : 492 }, "type" : "ARROW", "centre" : { "x" : 2892, "y" : 492 } }, "reactionShape" : { "c" : { "x" : 2868, "y" : 470 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2868, "y" : 470 } }, "inputs" : [ { "id" : 94286, "points" : [ { "x" : 2859, "y" : 436 } ] }, { "id" : 94284, "points" : [ { "x" : 2797, "y" : 441 } ] } ], "outputs" : [ { "id" : 94287 } ] }, { "id" : 94156, "reactomeId" : 10637360, "displayName" : "RHOA:GTP translocates to the ER membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 655, "y" : 217 }, "minX" : 643, "maxX" : 661, "minY" : 79, "maxY" : 294, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 643, "y" : 79 }, "to" : { "x" : 655, "y" : 217 } }, { "from" : { "x" : 655, "y" : 217 }, "to" : { "x" : 659, "y" : 294 } } ], "endShape" : { "a" : { "x" : 655, "y" : 287 }, "b" : { "x" : 659, "y" : 294 }, "c" : { "x" : 663, "y" : 287 }, "type" : "ARROW", "centre" : { "x" : 663, "y" : 287 } }, "reactionShape" : { "a" : { "x" : 649, "y" : 211 }, "b" : { "x" : 661, "y" : 223 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 655, "y" : 217 } }, "inputs" : [ { "id" : 94144 } ], "outputs" : [ { "id" : 94157 } ] }, { "id" : 94158, "reactomeId" : 10637358, "displayName" : "RHOA binds effectors at the ER membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 827, "y" : 280 }, "minX" : 743, "maxX" : 894, "minY" : 263, "maxY" : 297, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 743, "y" : 263 }, "to" : { "x" : 827, "y" : 280 } }, { "from" : { "x" : 827, "y" : 280 }, "to" : { "x" : 894, "y" : 297 } } ], "endShape" : { "a" : { "x" : 886, "y" : 299 }, "b" : { "x" : 894, "y" : 297 }, "c" : { "x" : 888, "y" : 291 }, "type" : "ARROW", "centre" : { "x" : 888, "y" : 291 } }, "reactionShape" : { "c" : { "x" : 827, "y" : 280 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 827, "y" : 280 } }, "inputs" : [ { "id" : 94157, "points" : [ { "x" : 680, "y" : 294 } ] }, { "id" : 94159, "points" : [ { "x" : 761, "y" : 295 } ] } ], "outputs" : [ { "id" : 94160 } ] }, { "id" : 94161, "reactomeId" : 10637420, "displayName" : "RHOB GEFs activate RHOB", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 59, "y" : 1020 }, "minX" : 52, "maxX" : 65, "minY" : 975, "maxY" : 1064, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 52, "y" : 975 }, "to" : { "x" : 59, "y" : 1020 } }, { "from" : { "x" : 59, "y" : 1020 }, "to" : { "x" : 55, "y" : 1064 } } ], "reactionShape" : { "a" : { "x" : 53, "y" : 1014 }, "b" : { "x" : 65, "y" : 1026 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 59, "y" : 1020 } }, "inputs" : [ { "id" : 94162, "points" : [ { "x" : 45, "y" : 944 } ] }, { "id" : 94163, "points" : [ { "x" : 99, "y" : 956 } ] } ], "outputs" : [ { "id" : 94164, "points" : [ { "x" : 46, "y" : 1097 } ] }, { "id" : 94165, "points" : [ { "x" : 117, "y" : 1073 } ] } ], "catalysts" : [ { "id" : 94166, "points" : [ { "x" : 91, "y" : 1016 } ] } ] }, { "id" : 94288, "reactomeId" : 10637706, "displayName" : "RHOG GEFs activate RHOG", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 49, "y" : 481 }, "minX" : 43, "maxX" : 55, "minY" : 432, "maxY" : 518, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 48, "y" : 432 }, "to" : { "x" : 49, "y" : 481 } }, { "from" : { "x" : 49, "y" : 481 }, "to" : { "x" : 51, "y" : 518 } } ], "reactionShape" : { "a" : { "x" : 43, "y" : 475 }, "b" : { "x" : 55, "y" : 487 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 49, "y" : 481 } }, "inputs" : [ { "id" : 94289, "points" : [ { "x" : 51, "y" : 401 } ] }, { "id" : 94290, "points" : [ { "x" : 98, "y" : 426 } ] } ], "outputs" : [ { "id" : 94291, "points" : [ { "x" : 46, "y" : 550 } ] }, { "id" : 94292, "points" : [ { "x" : 93, "y" : 525 } ] } ], "catalysts" : [ { "id" : 94293, "points" : [ { "x" : 113, "y" : 476 } ] } ] }, { "id" : 94167, "reactomeId" : 10637415, "displayName" : "RHOB GAPs stimulate RHOB GTPase activity", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 194, "y" : 1023 }, "minX" : 184, "maxX" : 200, "minY" : 914, "maxY" : 1105, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 187, "y" : 1105 }, "to" : { "x" : 194, "y" : 1023 } }, { "from" : { "x" : 194, "y" : 1023 }, "to" : { "x" : 184, "y" : 914 } } ], "reactionShape" : { "a" : { "x" : 188, "y" : 1017 }, "b" : { "x" : 200, "y" : 1029 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 194, "y" : 1023 } }, "inputs" : [ { "id" : 94164, "points" : [ { "x" : 82, "y" : 1109 } ] }, { "id" : 94168, "points" : [ { "x" : 210, "y" : 1120 } ] } ], "outputs" : [ { "id" : 94162, "points" : [ { "x" : 83, "y" : 925 } ] }, { "id" : 94169, "points" : [ { "x" : 224, "y" : 901 } ] } ], "catalysts" : [ { "id" : 94170, "points" : [ { "x" : 246, "y" : 1023 } ] } ] }, { "id" : 94294, "reactomeId" : 10637711, "displayName" : "RHOG GAPs stimulate RHOG GTPase activity", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 218, "y" : 475 }, "minX" : 212, "maxX" : 231, "minY" : 400, "maxY" : 556, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 215, "y" : 556 }, "to" : { "x" : 218, "y" : 475 } }, { "from" : { "x" : 218, "y" : 475 }, "to" : { "x" : 231, "y" : 400 } } ], "reactionShape" : { "a" : { "x" : 212, "y" : 469 }, "b" : { "x" : 224, "y" : 481 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 218, "y" : 475 } }, "inputs" : [ { "id" : 94291, "points" : [ { "x" : 84, "y" : 562 } ] }, { "id" : 94295, "points" : [ { "x" : 253, "y" : 580 } ] } ], "outputs" : [ { "id" : 94148, "points" : [ { "x" : 388, "y" : 271 } ] }, { "id" : 94289, "points" : [ { "x" : 93, "y" : 389 } ] } ], "catalysts" : [ { "id" : 94296, "points" : [ { "x" : 275, "y" : 469 } ] } ] }, { "id" : 94297, "reactomeId" : 10637735, "displayName" : "GDIs block activation of RHOG", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 118, "y" : 339 }, "minX" : 91, "maxX" : 141, "minY" : 333, "maxY" : 345, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 91, "y" : 339 }, "to" : { "x" : 118, "y" : 339 } }, { "from" : { "x" : 118, "y" : 339 }, "to" : { "x" : 141, "y" : 338 } } ], "endShape" : { "a" : { "x" : 134, "y" : 342 }, "b" : { "x" : 141, "y" : 338 }, "c" : { "x" : 134, "y" : 334 }, "type" : "ARROW", "centre" : { "x" : 134, "y" : 334 } }, "reactionShape" : { "c" : { "x" : 118, "y" : 339 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 118, "y" : 339 } }, "inputs" : [ { "id" : 94298, "points" : [ { "x" : 100, "y" : 309 } ] }, { "id" : 94289, "points" : [ { "x" : 61, "y" : 373 } ] } ], "outputs" : [ { "id" : 94299 } ] }, { "id" : 94171, "reactomeId" : 10637408, "displayName" : "GDIs block activation of RHOB", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 110, "y" : 887 }, "minX" : 85, "maxX" : 159, "minY" : 863, "maxY" : 893, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 85, "y" : 891 }, "to" : { "x" : 110, "y" : 887 } }, { "from" : { "x" : 110, "y" : 887 }, "to" : { "x" : 159, "y" : 863 } } ], "endShape" : { "a" : { "x" : 155, "y" : 870 }, "b" : { "x" : 159, "y" : 863 }, "c" : { "x" : 151, "y" : 862 }, "type" : "ARROW", "centre" : { "x" : 151, "y" : 862 } }, "reactionShape" : { "c" : { "x" : 110, "y" : 887 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 110, "y" : 887 } }, "inputs" : [ { "id" : 94162, "points" : [ { "x" : 55, "y" : 916 } ] }, { "id" : 94172, "points" : [ { "x" : 89, "y" : 823 } ] } ], "outputs" : [ { "id" : 94173 } ] }, { "id" : 94300, "reactomeId" : 10637725, "displayName" : "RHOG binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 93, "y" : 642 }, "minX" : 71, "maxX" : 105, "minY" : 612, "maxY" : 694, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 105, "y" : 612 }, "to" : { "x" : 93, "y" : 642 } }, { "from" : { "x" : 93, "y" : 642 }, "to" : { "x" : 71, "y" : 694 } } ], "endShape" : { "a" : { "x" : 70, "y" : 686 }, "b" : { "x" : 71, "y" : 694 }, "c" : { "x" : 77, "y" : 689 }, "type" : "ARROW", "centre" : { "x" : 77, "y" : 689 } }, "reactionShape" : { "c" : { "x" : 93, "y" : 642 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 93, "y" : 642 } }, "inputs" : [ { "id" : 94291, "points" : [ { "x" : 58, "y" : 578 } ] }, { "id" : 94301, "points" : [ { "x" : 151, "y" : 625 } ] } ], "outputs" : [ { "id" : 94302 } ] }, { "id" : 94303, "reactomeId" : 10637729, "displayName" : "RHOG translocates to the ER membrane", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 348, "y" : 639 }, "minX" : 84, "maxX" : 599, "minY" : 512, "maxY" : 645, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 84, "y" : 572 }, "to" : { "x" : 348, "y" : 639 } }, { "from" : { "x" : 348, "y" : 639 }, "to" : { "x" : 599, "y" : 512 } } ], "endShape" : { "a" : { "x" : 595, "y" : 519 }, "b" : { "x" : 599, "y" : 512 }, "c" : { "x" : 591, "y" : 512 }, "type" : "ARROW", "centre" : { "x" : 591, "y" : 512 } }, "reactionShape" : { "a" : { "x" : 342, "y" : 633 }, "b" : { "x" : 354, "y" : 645 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 348, "y" : 639 } }, "inputs" : [ { "id" : 94291 } ], "outputs" : [ { "id" : 94304 } ] }, { "id" : 94174, "reactomeId" : 10637426, "displayName" : "RHOB binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 77, "y" : 1233 }, "minX" : 71, "maxX" : 122, "minY" : 1135, "maxY" : 1269, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 86, "y" : 1135 }, "to" : { "x" : 77, "y" : 1233 } }, { "from" : { "x" : 77, "y" : 1233 }, "to" : { "x" : 122, "y" : 1269 } } ], "endShape" : { "a" : { "x" : 114, "y" : 1268 }, "b" : { "x" : 122, "y" : 1269 }, "c" : { "x" : 119, "y" : 1262 }, "type" : "ARROW", "centre" : { "x" : 119, "y" : 1262 } }, "reactionShape" : { "c" : { "x" : 77, "y" : 1233 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 77, "y" : 1233 } }, "inputs" : [ { "id" : 94175, "points" : [ { "x" : 134, "y" : 1161 } ] }, { "id" : 94164, "points" : [ { "x" : 63, "y" : 1125 } ] } ], "outputs" : [ { "id" : 94176 } ] }, { "id" : 94305, "reactomeId" : 10637759, "displayName" : "RHOG binds effectors at the ER membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 720, "y" : 474 }, "minX" : 676, "maxX" : 726, "minY" : 421, "maxY" : 505, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 709, "y" : 505 }, "to" : { "x" : 720, "y" : 474 } }, { "from" : { "x" : 720, "y" : 474 }, "to" : { "x" : 676, "y" : 421 } } ], "endShape" : { "a" : { "x" : 684, "y" : 424 }, "b" : { "x" : 676, "y" : 421 }, "c" : { "x" : 677, "y" : 429 }, "type" : "ARROW", "centre" : { "x" : 677, "y" : 429 } }, "reactionShape" : { "c" : { "x" : 720, "y" : 474 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 720, "y" : 474 } }, "inputs" : [ { "id" : 94304, "points" : [ { "x" : 660, "y" : 500 } ] }, { "id" : 94306, "points" : [ { "x" : 664, "y" : 532 } ] } ], "outputs" : [ { "id" : 94307 } ] }, { "id" : 94177, "reactomeId" : 10637441, "displayName" : "RHOC GEFs activate RHOC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 51, "y" : 1517 }, "minX" : 45, "maxX" : 57, "minY" : 1479, "maxY" : 1565, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 54, "y" : 1479 }, "to" : { "x" : 51, "y" : 1517 } }, { "from" : { "x" : 51, "y" : 1517 }, "to" : { "x" : 52, "y" : 1565 } } ], "reactionShape" : { "a" : { "x" : 45, "y" : 1511 }, "b" : { "x" : 57, "y" : 1523 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 51, "y" : 1517 } }, "inputs" : [ { "id" : 94178, "points" : [ { "x" : 57, "y" : 1438 } ] }, { "id" : 94179, "points" : [ { "x" : 98, "y" : 1472 } ] } ], "outputs" : [ { "id" : 94180, "points" : [ { "x" : 52, "y" : 1602 } ] }, { "id" : 94181, "points" : [ { "x" : 120, "y" : 1566 } ] } ], "catalysts" : [ { "id" : 94182, "points" : [ { "x" : 100, "y" : 1515 } ] } ] }, { "id" : 94308, "reactomeId" : 10637933, "displayName" : "RHOBTB1 binds GTP", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 490, "y" : 1943 }, "minX" : 457, "maxX" : 541, "minY" : 1937, "maxY" : 1949, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 457, "y" : 1943 }, "to" : { "x" : 490, "y" : 1943 } }, { "from" : { "x" : 490, "y" : 1943 }, "to" : { "x" : 541, "y" : 1944 } } ], "endShape" : { "a" : { "x" : 534, "y" : 1948 }, "b" : { "x" : 541, "y" : 1944 }, "c" : { "x" : 534, "y" : 1940 }, "type" : "ARROW", "centre" : { "x" : 534, "y" : 1940 } }, "reactionShape" : { "a" : { "x" : 484, "y" : 1937 }, "b" : { "x" : 496, "y" : 1949 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 490, "y" : 1943 } }, "inputs" : [ { "id" : 94309, "points" : [ { "x" : 427, "y" : 1941 } ] }, { "id" : 94310, "points" : [ { "x" : 448, "y" : 1899 } ] } ], "outputs" : [ { "id" : 94311 } ] }, { "id" : 94183, "reactomeId" : 10637452, "displayName" : "RHOC GAPs stimulate RHOC GTPase activity", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 231, "y" : 1511 }, "minX" : 225, "maxX" : 237, "minY" : 1445, "maxY" : 1587, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 231, "y" : 1587 }, "to" : { "x" : 231, "y" : 1511 } }, { "from" : { "x" : 231, "y" : 1511 }, "to" : { "x" : 230, "y" : 1445 } } ], "reactionShape" : { "a" : { "x" : 225, "y" : 1505 }, "b" : { "x" : 237, "y" : 1517 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 231, "y" : 1511 } }, "inputs" : [ { "id" : 94184, "points" : [ { "x" : 252, "y" : 1607 } ] }, { "id" : 94180, "points" : [ { "x" : 92, "y" : 1610 } ] } ], "outputs" : [ { "id" : 94178, "points" : [ { "x" : 98, "y" : 1428 } ] }, { "id" : 94185, "points" : [ { "x" : 252, "y" : 1429 } ] } ], "catalysts" : [ { "id" : 94186, "points" : [ { "x" : 282, "y" : 1511 } ] } ] }, { "id" : 94312, "reactomeId" : 10637953, "displayName" : "RHOBTB1 binds interacting proteins at the endosome membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 704, "y" : 1943 }, "minX" : 664, "maxX" : 778, "minY" : 1937, "maxY" : 1949, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 664, "y" : 1942 }, "to" : { "x" : 704, "y" : 1943 } }, { "from" : { "x" : 704, "y" : 1943 }, "to" : { "x" : 778, "y" : 1944 } } ], "endShape" : { "a" : { "x" : 771, "y" : 1948 }, "b" : { "x" : 778, "y" : 1944 }, "c" : { "x" : 771, "y" : 1940 }, "type" : "ARROW", "centre" : { "x" : 771, "y" : 1940 } }, "reactionShape" : { "c" : { "x" : 704, "y" : 1943 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 704, "y" : 1943 } }, "inputs" : [ { "id" : 94313, "points" : [ { "x" : 648, "y" : 1881 } ] }, { "id" : 94311, "points" : [ { "x" : 640, "y" : 1943 } ] } ], "outputs" : [ { "id" : 94314 } ] }, { "id" : 94315, "reactomeId" : 10637969, "displayName" : "RHOV binds GTP", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 648, "y" : 2397 }, "minX" : 607, "maxX" : 678, "minY" : 2391, "maxY" : 2403, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 607, "y" : 2396 }, "to" : { "x" : 648, "y" : 2397 } }, { "from" : { "x" : 648, "y" : 2397 }, "to" : { "x" : 678, "y" : 2397 } } ], "reactionShape" : { "a" : { "x" : 642, "y" : 2391 }, "b" : { "x" : 654, "y" : 2403 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 648, "y" : 2397 } }, "inputs" : [ { "id" : 94316, "points" : [ { "x" : 556, "y" : 2406 } ] }, { "id" : 94317, "points" : [ { "x" : 573, "y" : 2353 } ] } ], "outputs" : [ { "id" : 94318, "points" : [ { "x" : 712, "y" : 2406 } ] }, { "id" : 94319, "points" : [ { "x" : 706, "y" : 2365 } ] } ] }, { "id" : 94187, "reactomeId" : 10637436, "displayName" : "GDIs block activation of RHOC", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 264, "y" : 1386 }, "minX" : 180, "maxX" : 324, "minY" : 1373, "maxY" : 1400, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 180, "y" : 1400 }, "to" : { "x" : 264, "y" : 1386 } }, { "from" : { "x" : 264, "y" : 1386 }, "to" : { "x" : 324, "y" : 1373 } } ], "endShape" : { "a" : { "x" : 318, "y" : 1378 }, "b" : { "x" : 324, "y" : 1373 }, "c" : { "x" : 316, "y" : 1371 }, "type" : "ARROW", "centre" : { "x" : 316, "y" : 1371 } }, "reactionShape" : { "c" : { "x" : 264, "y" : 1386 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 264, "y" : 1386 } }, "inputs" : [ { "id" : 94178, "points" : [ { "x" : 98, "y" : 1416 } ] }, { "id" : 94188, "points" : [ { "x" : 155, "y" : 1378 } ] } ], "outputs" : [ { "id" : 94189 } ] }, { "id" : 94190, "reactomeId" : 10637447, "displayName" : "RHOC binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 71, "y" : 1716 }, "minX" : 58, "maxX" : 77, "minY" : 1656, "maxY" : 1788, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 72, "y" : 1656 }, "to" : { "x" : 71, "y" : 1716 } }, { "from" : { "x" : 71, "y" : 1716 }, "to" : { "x" : 58, "y" : 1788 } } ], "endShape" : { "a" : { "x" : 55, "y" : 1780 }, "b" : { "x" : 58, "y" : 1788 }, "c" : { "x" : 63, "y" : 1782 }, "type" : "ARROW", "centre" : { "x" : 63, "y" : 1782 } }, "reactionShape" : { "c" : { "x" : 71, "y" : 1716 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 71, "y" : 1716 } }, "inputs" : [ { "id" : 94180, "points" : [ { "x" : 57, "y" : 1630 } ] }, { "id" : 94191, "points" : [ { "x" : 124, "y" : 1667 } ] } ], "outputs" : [ { "id" : 94192 } ] }, { "id" : 94193, "reactomeId" : 10637469, "displayName" : "RAC1 GEFs activate RAC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1065, "y" : 59 }, "minX" : 1025, "maxX" : 1101, "minY" : 53, "maxY" : 65, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1025, "y" : 65 }, "to" : { "x" : 1065, "y" : 59 } }, { "from" : { "x" : 1065, "y" : 59 }, "to" : { "x" : 1101, "y" : 60 } } ], "reactionShape" : { "a" : { "x" : 1059, "y" : 53 }, "b" : { "x" : 1071, "y" : 65 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1065, "y" : 59 } }, "inputs" : [ { "id" : 94194, "points" : [ { "x" : 987, "y" : 63 } ] }, { "id" : 94195, "points" : [ { "x" : 1009, "y" : 88 } ] } ], "outputs" : [ { "id" : 94196, "points" : [ { "x" : 1177, "y" : 70 } ] }, { "id" : 94197, "points" : [ { "x" : 1127, "y" : 93 } ] } ], "catalysts" : [ { "id" : 94198, "points" : [ { "x" : 1064, "y" : 119 } ] } ] }, { "id" : 94320, "reactomeId" : 10637965, "displayName" : "RHOV binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 826, "y" : 2362 }, "minX" : 801, "maxX" : 857, "minY" : 2356, "maxY" : 2391, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 801, "y" : 2364 }, "to" : { "x" : 826, "y" : 2362 } }, { "from" : { "x" : 826, "y" : 2362 }, "to" : { "x" : 857, "y" : 2391 } } ], "endShape" : { "a" : { "x" : 849, "y" : 2389 }, "b" : { "x" : 857, "y" : 2391 }, "c" : { "x" : 855, "y" : 2383 }, "type" : "ARROW", "centre" : { "x" : 855, "y" : 2383 } }, "reactionShape" : { "c" : { "x" : 826, "y" : 2362 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 826, "y" : 2362 } }, "inputs" : [ { "id" : 94318, "points" : [ { "x" : 761, "y" : 2401 } ] }, { "id" : 94321, "points" : [ { "x" : 813, "y" : 2307 } ] } ], "outputs" : [ { "id" : 94322 } ] }, { "id" : 94323, "reactomeId" : 10637984, "displayName" : "RAC3 GEFs activate RAC3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3185, "y" : 341 }, "minX" : 3179, "maxX" : 3191, "minY" : 285, "maxY" : 399, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3183, "y" : 285 }, "to" : { "x" : 3185, "y" : 341 } }, { "from" : { "x" : 3185, "y" : 341 }, "to" : { "x" : 3183, "y" : 399 } } ], "reactionShape" : { "a" : { "x" : 3179, "y" : 335 }, "b" : { "x" : 3191, "y" : 347 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3185, "y" : 341 } }, "inputs" : [ { "id" : 94324, "points" : [ { "x" : 3181, "y" : 242 } ] }, { "id" : 94325, "points" : [ { "x" : 3137, "y" : 275 } ] } ], "outputs" : [ { "id" : 94326, "points" : [ { "x" : 3182, "y" : 487 } ] }, { "id" : 94327, "points" : [ { "x" : 3144, "y" : 427 } ] } ], "catalysts" : [ { "id" : 94328, "points" : [ { "x" : 3146, "y" : 342 } ] } ] }, { "id" : 94199, "reactomeId" : 10637512, "displayName" : "RAC1 GAPs stimulate RAC1 GTPase activity", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1068, "y" : 175 }, "minX" : 978, "maxX" : 1129, "minY" : 169, "maxY" : 185, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1129, "y" : 185 }, "to" : { "x" : 1068, "y" : 175 } }, { "from" : { "x" : 1068, "y" : 175 }, "to" : { "x" : 978, "y" : 173 } } ], "reactionShape" : { "a" : { "x" : 1062, "y" : 169 }, "b" : { "x" : 1074, "y" : 181 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1068, "y" : 175 } }, "inputs" : [ { "id" : 94196, "points" : [ { "x" : 1205, "y" : 89 } ] }, { "id" : 94200, "points" : [ { "x" : 1151, "y" : 200 } ] } ], "outputs" : [ { "id" : 94194, "points" : [ { "x" : 951, "y" : 76 } ] }, { "id" : 94201, "points" : [ { "x" : 936, "y" : 198 } ] } ], "catalysts" : [ { "id" : 94202, "points" : [ { "x" : 1065, "y" : 212 } ] } ] }, { "id" : 94329, "reactomeId" : 10637989, "displayName" : "RAC3 GAPs stimulate RAC3 GTPase activity", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3022, "y" : 349 }, "minX" : 3016, "maxX" : 3028, "minY" : 256, "maxY" : 477, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3027, "y" : 477 }, "to" : { "x" : 3022, "y" : 349 } }, { "from" : { "x" : 3022, "y" : 349 }, "to" : { "x" : 3022, "y" : 256 } } ], "reactionShape" : { "a" : { "x" : 3016, "y" : 343 }, "b" : { "x" : 3028, "y" : 355 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3022, "y" : 349 } }, "inputs" : [ { "id" : 94330, "points" : [ { "x" : 3015, "y" : 499 } ] }, { "id" : 94326, "points" : [ { "x" : 3145, "y" : 495 } ] } ], "outputs" : [ { "id" : 94324, "points" : [ { "x" : 3143, "y" : 233 } ] }, { "id" : 94331, "points" : [ { "x" : 2990, "y" : 254 } ] } ], "catalysts" : [ { "id" : 94332, "points" : [ { "x" : 2985, "y" : 349 } ] } ] }, { "id" : 94203, "reactomeId" : 10637568, "displayName" : "RAC1 GDIs block activation of RAC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 883, "y" : 186 }, "minX" : 855, "maxX" : 913, "minY" : 131, "maxY" : 220, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 913, "y" : 131 }, "to" : { "x" : 883, "y" : 186 } }, { "from" : { "x" : 883, "y" : 186 }, "to" : { "x" : 855, "y" : 220 } } ], "endShape" : { "a" : { "x" : 856, "y" : 212 }, "b" : { "x" : 855, "y" : 220 }, "c" : { "x" : 862, "y" : 217 }, "type" : "ARROW", "centre" : { "x" : 862, "y" : 217 } }, "reactionShape" : { "c" : { "x" : 883, "y" : 186 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 883, "y" : 186 } }, "inputs" : [ { "id" : 94194, "points" : [ { "x" : 943, "y" : 76 } ] }, { "id" : 94151, "points" : [ { "x" : 231, "y" : 101 }, { "x" : 232, "y" : 0 }, { "x" : 894, "y" : 2 } ] } ], "outputs" : [ { "id" : 94204 } ] }, { "id" : 94333, "reactomeId" : 10637997, "displayName" : "RAC3 GDIs block activation of RAC3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3094, "y" : 207 }, "minX" : 3061, "maxX" : 3126, "minY" : 177, "maxY" : 213, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3126, "y" : 177 }, "to" : { "x" : 3094, "y" : 207 } }, { "from" : { "x" : 3094, "y" : 207 }, "to" : { "x" : 3061, "y" : 198 } } ], "endShape" : { "a" : { "x" : 3069, "y" : 196 }, "b" : { "x" : 3061, "y" : 198 }, "c" : { "x" : 3067, "y" : 204 }, "type" : "ARROW", "centre" : { "x" : 3067, "y" : 204 } }, "reactionShape" : { "c" : { "x" : 3094, "y" : 207 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3094, "y" : 207 } }, "inputs" : [ { "id" : 94324, "points" : [ { "x" : 3168, "y" : 213 } ] }, { "id" : 94334, "points" : [ { "x" : 3107, "y" : 141 } ] } ], "outputs" : [ { "id" : 94335 } ] }, { "id" : 94205, "reactomeId" : 10637564, "displayName" : "RAC1 binds effectors at the plasma membrane", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1332, "y" : 61 }, "minX" : 1306, "maxX" : 1369, "minY" : 55, "maxY" : 102, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1306, "y" : 102 }, "to" : { "x" : 1332, "y" : 61 } }, { "from" : { "x" : 1332, "y" : 61 }, "to" : { "x" : 1369, "y" : 62 } } ], "endShape" : { "a" : { "x" : 1362, "y" : 66 }, "b" : { "x" : 1369, "y" : 62 }, "c" : { "x" : 1362, "y" : 58 }, "type" : "ARROW", "centre" : { "x" : 1362, "y" : 58 } }, "reactionShape" : { "c" : { "x" : 1332, "y" : 61 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1332, "y" : 61 } }, "inputs" : [ { "id" : 94196, "points" : [ { "x" : 1252, "y" : 85 } ] }, { "id" : 94206, "points" : [ { "x" : 1284, "y" : 144 } ] } ], "outputs" : [ { "id" : 94207 } ] } ], "compartments" : [ { "id" : 94417, "reactomeId" : 20699, "displayName" : "Golgi membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2633, "y" : 850 }, "minX" : 2500, "maxX" : 2767, "minY" : 767, "maxY" : 934, "prop" : { "x" : 2500, "y" : 767, "width" : 267, "height" : 167 }, "textPosition" : { "x" : 2575, "y" : 834 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 94416, "reactomeId" : 17906, "displayName" : "mitochondrial outer membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1870, "y" : 567 }, "minX" : 1613, "maxX" : 2128, "minY" : 493, "maxY" : 642, "prop" : { "x" : 1613, "y" : 493, "width" : 515, "height" : 149 }, "textPosition" : { "x" : 1829, "y" : 546 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 94393, 94394, 94395, 94396 ] }, { "id" : 94418, "reactomeId" : 171907, "displayName" : "endosome lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 605, "y" : 2067 }, "minX" : 322, "maxX" : 888, "minY" : 1938, "maxY" : 2197, "prop" : { "x" : 322, "y" : 1938, "width" : 566, "height" : 259 }, "textPosition" : { "x" : 336, "y" : 2116 }, "insets" : { "x" : 332, "y" : 1948, "width" : 546, "height" : 239 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 94311, 94314, 94309, 94308, 94312, 94403 ] }, { "id" : 94405, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 865, "y" : 596 }, "minX" : 605, "maxX" : 1125, "minY" : 297, "maxY" : 895, "prop" : { "x" : 605, "y" : 297, "width" : 520, "height" : 598 }, "textPosition" : { "x" : 702, "y" : 604 }, "insets" : { "x" : 615, "y" : 307, "width" : 500, "height" : 578 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 94157, 94406, 94304, 94305, 94345, 94346, 94350, 94351, 94159, 94160, 94347, 94348, 94391, 94306, 94307, 94352, 94353, 94398, 94423, 94400 ] }, { "id" : 94404, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1612, "y" : 1235 }, "minX" : 26, "maxX" : 3198, "minY" : 46, "maxY" : 2424, "prop" : { "x" : 26, "y" : 46, "width" : 3172, "height" : 2378 }, "textPosition" : { "x" : 57, "y" : 2365 }, "insets" : { "x" : 36, "y" : 56, "width" : 3152, "height" : 2358 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 94144, 94143, 94140, 94141, 94142, 94146, 94148, 94150, 94151, 94152, 94153, 94155, 94156, 94405, 94149, 94162, 94164, 94165, 94163, 94147, 94167, 94170, 94168, 94171, 94172, 94173, 94169, 94174, 94175, 94176, 94178, 94180, 94179, 94181, 94183, 94184, 94185, 94187, 94189, 94192, 94194, 94195, 94197, 94193, 94199, 94202, 94201, 94203, 94204, 94205, 94207, 94206, 94208, 94209, 94211, 94210, 94212, 94216, 94214, 94218, 94219, 94220, 94221, 94411, 94215, 94217, 94223, 94224, 94225, 94227, 94226, 94228, 94230, 94231, 94232, 94235, 94237, 94236, 94238, 94234, 94240, 94241, 94242, 94244, 94246, 94247, 94413, 94252, 94255, 94254, 94368, 94256, 94257, 94258, 94259, 94260, 94262, 94261, 94263, 94264, 94265, 94266, 94267, 94268, 94270, 94269, 94271, 94273, 94274, 94275, 94277, 94279, 94280, 94282, 94283, 94414, 94288, 94289, 94291, 94293, 94290, 94292, 94294, 94295, 94296, 94297, 94298, 94299, 94300, 94301, 94302, 94303, 94190, 94315, 94318, 94317, 94319, 94316, 94320, 94321, 94322, 94323, 94327, 94325, 94324, 94326, 94329, 94330, 94331, 94333, 94335, 94336, 94338, 94161, 94177, 94200, 94196, 94198, 94213, 94272, 94328, 94145, 94158, 94339, 94341, 94342, 94344, 94276, 94332, 94334, 94337, 94416, 94349, 94417, 94354, 94355, 94357, 94356, 94358, 94360, 94362, 94361, 94359, 94363, 94364, 94365, 94239, 94243, 94245, 94233, 94253, 94366, 94154, 94191, 94369, 94370, 94372, 94371, 94373, 94375, 94376, 94378, 94377, 94379, 94382, 94380, 94384, 94386, 94383, 94385, 94387, 94389, 94374, 94381, 94388, 94418, 94310, 94313, 94186, 94281, 94390, 94392, 94229, 94397, 94222, 94399, 94367, 94278, 94188, 94182, 94166, 94402, 94401 ] }, { "id" : 94411, "reactomeId" : 171907, "displayName" : "endosome lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2406, "y" : 583 }, "minX" : 2285, "maxX" : 2528, "minY" : 480, "maxY" : 687, "prop" : { "x" : 2285, "y" : 480, "width" : 243, "height" : 207 }, "textPosition" : { "x" : 2347, "y" : 567 }, "insets" : { "x" : 2295, "y" : 490, "width" : 223, "height" : 187 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 94340, 94343 ] }, { "id" : 94413, "reactomeId" : 13949, "displayName" : "Golgi-associated vesicle membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2588, "y" : 1440 }, "minX" : 2483, "maxX" : 2694, "minY" : 1357, "maxY" : 1523, "prop" : { "x" : 2483, "y" : 1357, "width" : 211, "height" : 166 }, "textPosition" : { "x" : 2486, "y" : 1465 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 94248, 94249, 94250, 94251 ] }, { "id" : 94414, "reactomeId" : 1222693, "displayName" : "phagocytic vesicle membrane", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2801, "y" : 468 }, "minX" : 2717, "maxX" : 2885, "minY" : 412, "maxY" : 525, "prop" : { "x" : 2717, "y" : 412, "width" : 168, "height" : 113 }, "textPosition" : { "x" : 2720, "y" : 475 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 94284, 94287, 94286, 94285 ] } ], "notes" : [ { "id" : 94406, "displayName" : "endoplasmic reticulum membrane", "renderableClass" : "Note", "position" : { "x" : 729, "y" : 348 }, "minX" : 625, "maxX" : 833, "minY" : 337, "maxY" : 359, "prop" : { "x" : 625, "y" : 337, "width" : 208, "height" : 22 }, "textPosition" : { "x" : 652, "y" : 331 } } ], "links" : [ { "id" : 94423, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 902, "y" : 365 }, "minX" : 896, "maxX" : 908, "minY" : 359, "maxY" : 371, "segments" : [ ], "reactionShape" : { "a" : { "x" : 896, "y" : 359 }, "b" : { "x" : 908, "y" : 371 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 902, "y" : 365 } }, "inputs" : [ { "id" : 94352 } ], "outputs" : [ { "id" : 94347 } ] } ], "shadows" : [ { "id" : 94433, "reactomeId" : 10650424, "displayName" : "RHOH GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 3077, "y" : 2053 }, "minX" : 2908, "maxX" : 3246, "minY" : 1865, "maxY" : 2241, "prop" : { "x" : 2908, "y" : 1865, "width" : 338, "height" : 376 }, "points" : [ { "x" : 2908, "y" : 1865 }, { "x" : 3246, "y" : 1865 }, { "x" : 3246, "y" : 2241 }, { "x" : 2908, "y" : 2241 } ], "colour" : "#aaaa11" }, { "id" : 94432, "reactomeId" : 10650422, "displayName" : "RHOJ GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 3023, "y" : 1044 }, "minX" : 2838, "maxX" : 3208, "minY" : 931, "maxY" : 1158, "prop" : { "x" : 2838, "y" : 1073, "width" : 370, "height" : 85 }, "points" : [ { "x" : 2838, "y" : 931 }, { "x" : 3208, "y" : 931 }, { "x" : 3208, "y" : 1158 }, { "x" : 2838, "y" : 1158 } ], "colour" : "#dd4477" }, { "id" : 94435, "reactomeId" : 10650430, "displayName" : "RHOBTB GTPase Cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 629, "y" : 1907 }, "minX" : 345, "maxX" : 913, "minY" : 1836, "maxY" : 1979, "prop" : { "x" : 345, "y" : 1836, "width" : 568, "height" : 143 }, "points" : [ { "x" : 345, "y" : 1836 }, { "x" : 913, "y" : 1836 }, { "x" : 913, "y" : 1979 }, { "x" : 345, "y" : 1979 } ], "colour" : "#888888" }, { "id" : 94434, "reactomeId" : 10650426, "displayName" : "RHOU GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1262, "y" : 2247 }, "minX" : 821, "maxX" : 1704, "minY" : 2047, "maxY" : 2447, "prop" : { "x" : 821, "y" : 2047, "width" : 883, "height" : 222 }, "points" : [ { "x" : 821, "y" : 2047 }, { "x" : 1704, "y" : 2047 }, { "x" : 1704, "y" : 2447 }, { "x" : 821, "y" : 2447 } ], "colour" : "#66aa00" }, { "id" : 94437, "reactomeId" : 10650434, "displayName" : "RAC3 GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2117, "y" : 556 }, "minX" : 984, "maxX" : 3251, "minY" : 103, "maxY" : 1010, "prop" : { "x" : 3092, "y" : 103, "width" : 159, "height" : 513 }, "points" : [ { "x" : 984, "y" : 103 }, { "x" : 3251, "y" : 103 }, { "x" : 3251, "y" : 1010 }, { "x" : 984, "y" : 1010 } ], "colour" : "#dd5511" }, { "id" : 94436, "reactomeId" : 10650432, "displayName" : "RHOV GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 702, "y" : 2355 }, "minX" : 471, "maxX" : 934, "minY" : 2269, "maxY" : 2441, "prop" : { "x" : 471, "y" : 2269, "width" : 350, "height" : 172 }, "points" : [ { "x" : 471, "y" : 2269 }, { "x" : 934, "y" : 2269 }, { "x" : 934, "y" : 2441 }, { "x" : 471, "y" : 2441 } ], "colour" : "#994499" }, { "id" : 94439, "reactomeId" : 10650576, "displayName" : "RND2 GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2386, "y" : 2390 }, "minX" : 2158, "maxX" : 2614, "minY" : 2340, "maxY" : 2441, "prop" : { "x" : 2158, "y" : 2340, "width" : 456, "height" : 101 }, "points" : [ { "x" : 2158, "y" : 2340 }, { "x" : 2614, "y" : 2340 }, { "x" : 2614, "y" : 2441 }, { "x" : 2158, "y" : 2441 } ], "colour" : "#999999" }, { "id" : 94438, "reactomeId" : 10650574, "displayName" : "RHOF GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 3067, "y" : 761 }, "minX" : 2889, "maxX" : 3246, "minY" : 616, "maxY" : 906, "prop" : { "x" : 3092, "y" : 616, "width" : 154, "height" : 290 }, "points" : [ { "x" : 2889, "y" : 616 }, { "x" : 3246, "y" : 616 }, { "x" : 3246, "y" : 906 }, { "x" : 2889, "y" : 906 } ], "colour" : "#22aa99" }, { "id" : 94441, "reactomeId" : 10650580, "displayName" : "RND1 GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1927, "y" : 2385 }, "minX" : 1709, "maxX" : 2146, "minY" : 2329, "maxY" : 2442, "prop" : { "x" : 1709, "y" : 2329, "width" : 437, "height" : 113 }, "points" : [ { "x" : 1709, "y" : 2329 }, { "x" : 2146, "y" : 2329 }, { "x" : 2146, "y" : 2442 }, { "x" : 1709, "y" : 2442 } ], "colour" : "#109618" }, { "id" : 94440, "reactomeId" : 10650578, "displayName" : "RND3 GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2886, "y" : 2382 }, "minX" : 2634, "maxX" : 3138, "minY" : 2326, "maxY" : 2439, "prop" : { "x" : 2634, "y" : 2326, "width" : 504, "height" : 113 }, "points" : [ { "x" : 2634, "y" : 2326 }, { "x" : 3138, "y" : 2326 }, { "x" : 3138, "y" : 2439 }, { "x" : 2634, "y" : 2439 } ], "colour" : "#705770" }, { "id" : 94425, "reactomeId" : 10650382, "displayName" : "RHOA GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 600, "y" : 187 }, "minX" : 178, "maxX" : 1023, "minY" : 28, "maxY" : 347, "prop" : { "x" : 178, "y" : 28, "width" : 845, "height" : 319 }, "points" : [ { "x" : 178, "y" : 28 }, { "x" : 1023, "y" : 28 }, { "x" : 1023, "y" : 347 }, { "x" : 178, "y" : 347 } ], "colour" : "#dc3912" }, { "id" : 94424, "reactomeId" : 10649978, "displayName" : "RHOQ GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2877, "y" : 1561 }, "minX" : 2520, "maxX" : 3234, "minY" : 1317, "maxY" : 1806, "prop" : { "x" : 2520, "y" : 1317, "width" : 714, "height" : 489 }, "points" : [ { "x" : 2520, "y" : 1317 }, { "x" : 3234, "y" : 1317 }, { "x" : 3234, "y" : 1806 }, { "x" : 2520, "y" : 1806 } ], "colour" : "#4684ee" }, { "id" : 94427, "reactomeId" : 10650410, "displayName" : "RHOC GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 340, "y" : 1344 }, "minX" : -6, "maxX" : 687, "minY" : 855, "maxY" : 1834, "prop" : { "x" : -6, "y" : 1333, "width" : 693, "height" : 501 }, "points" : [ { "x" : -6, "y" : 855 }, { "x" : 687, "y" : 855 }, { "x" : 687, "y" : 1834 }, { "x" : -6, "y" : 1834 } ], "colour" : "#666666" }, { "id" : 94426, "reactomeId" : 10650408, "displayName" : "RHOB GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1241, "y" : 965 }, "minX" : -1, "maxX" : 2483, "minY" : 598, "maxY" : 1333, "prop" : { "x" : 687, "y" : 1073, "width" : 1796, "height" : 260 }, "points" : [ { "x" : -1, "y" : 598 }, { "x" : 2483, "y" : 598 }, { "x" : 2483, "y" : 1333 }, { "x" : -1, "y" : 1333 } ], "colour" : "#008000" }, { "id" : 94429, "reactomeId" : 10650414, "displayName" : "CDC42 GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1406, "y" : 343 }, "minX" : 753, "maxX" : 2060, "minY" : 40, "maxY" : 647, "prop" : { "x" : 753, "y" : 40, "width" : 1307, "height" : 607 }, "points" : [ { "x" : 753, "y" : 40 }, { "x" : 2060, "y" : 40 }, { "x" : 2060, "y" : 647 }, { "x" : 753, "y" : 647 } ], "colour" : "#cb4ac5" }, { "id" : 94428, "reactomeId" : 10650412, "displayName" : "RAC1 GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 828, "y" : 271 }, "minX" : 178, "maxX" : 1478, "minY" : 35, "maxY" : 508, "prop" : { "x" : 178, "y" : 35, "width" : 1300, "height" : 473 }, "points" : [ { "x" : 178, "y" : 35 }, { "x" : 1478, "y" : 35 }, { "x" : 1478, "y" : 508 }, { "x" : 178, "y" : 508 } ], "colour" : "#4942cc" }, { "id" : 94431, "reactomeId" : 10650418, "displayName" : "RHOG GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 378, "y" : 495 }, "minX" : -10, "maxX" : 766, "minY" : 234, "maxY" : 757, "prop" : { "x" : -10, "y" : 508, "width" : 763, "height" : 90 }, "points" : [ { "x" : -10, "y" : 234 }, { "x" : 766, "y" : 234 }, { "x" : 766, "y" : 757 }, { "x" : -10, "y" : 757 } ], "colour" : "#336699" }, { "id" : 94430, "reactomeId" : 10650416, "displayName" : "RAC2 GTPase cycle", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1983, "y" : 555 }, "minX" : 874, "maxX" : 3092, "minY" : 38, "maxY" : 1073, "prop" : { "x" : 2060, "y" : 40, "width" : 1032, "height" : 63 }, "points" : [ { "x" : 874, "y" : 38 }, { "x" : 3092, "y" : 38 }, { "x" : 3092, "y" : 1073 }, { "x" : 874, "y" : 1073 } ], "colour" : "#d6ae00" } ], "minX" : 0, "maxX" : 3247, "minY" : 0, "maxY" : 2445, "disease" : false }