{
  "dbId" : 10650298,
  "stableId" : "R-DRE-8934593",
  "displayName" : "Regulation of RUNX1 Expression and Activity",
  "nodes" : [ {
    "id" : 43780,
    "reactomeId" : 10633465,
    "displayName" : "CDK6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 397,
      "y" : 577
    },
    "minX" : 376,
    "maxX" : 461,
    "minY" : 560,
    "maxY" : 588,
    "prop" : {
      "x" : 376,
      "y" : 566,
      "width" : 42,
      "height" : 22
    },
    "textPosition" : {
      "x" : 377,
      "y" : 566
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 418,
          "y" : 566
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 418,
          "y" : 566
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 43779,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 421,
          "y" : 578
        },
        "to" : {
          "x" : 461,
          "y" : 583
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 43781,
    "reactomeId" : 10633467,
    "displayName" : "RUNX1,RUNX1:CBFB",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 467,
      "y" : 528
    },
    "minX" : 404,
    "maxX" : 531,
    "minY" : 517,
    "maxY" : 583,
    "prop" : {
      "x" : 404,
      "y" : 517,
      "width" : 127,
      "height" : 22
    },
    "textPosition" : {
      "x" : 418,
      "y" : 511
    },
    "connectors" : [ {
      "edgeId" : 43779,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 465,
          "y" : 545
        },
        "to" : {
          "x" : 461,
          "y" : 583
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 43782,
    "reactomeId" : 10633469,
    "displayName" : "RUNX1,RUNX1:CBFB:CDK6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 462,
      "y" : 761
    },
    "minX" : 413,
    "maxX" : 518,
    "minY" : 736,
    "maxY" : 780,
    "prop" : {
      "x" : 413,
      "y" : 742,
      "width" : 99,
      "height" : 38
    },
    "textPosition" : {
      "x" : 413,
      "y" : 745
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 512,
          "y" : 742
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 512,
          "y" : 742
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 43779,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 43784,
    "reactomeId" : 10631446,
    "displayName" : "cbfb",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 594,
      "y" : 575
    },
    "minX" : 576,
    "maxX" : 677,
    "minY" : 558,
    "maxY" : 613,
    "prop" : {
      "x" : 576,
      "y" : 564,
      "width" : 37,
      "height" : 22
    },
    "textPosition" : {
      "x" : 577,
      "y" : 564
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 613,
          "y" : 564
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 613,
          "y" : 564
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 43783,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 616,
          "y" : 583
        },
        "to" : {
          "x" : 677,
          "y" : 613
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 43785,
    "reactomeId" : 10631448,
    "displayName" : "RUNX1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 723,
      "y" : 551
    },
    "minX" : 677,
    "maxX" : 759,
    "minY" : 534,
    "maxY" : 713,
    "prop" : {
      "x" : 693,
      "y" : 540,
      "width" : 60,
      "height" : 23
    },
    "textPosition" : {
      "x" : 698,
      "y" : 541
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 753,
          "y" : 540
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 753,
          "y" : 540
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 43783,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 714,
          "y" : 566
        },
        "to" : {
          "x" : 677,
          "y" : 613
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 43788,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 720,
          "y" : 566
        },
        "to" : {
          "x" : 693,
          "y" : 713
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 43801,
    "reactomeId" : 10650300,
    "displayName" : "Transcriptional regulation by RUNX1",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 515,
      "y" : 867
    },
    "minX" : 411,
    "maxX" : 619,
    "minY" : 829,
    "maxY" : 905,
    "prop" : {
      "x" : 411,
      "y" : 829,
      "width" : 208,
      "height" : 76
    },
    "textPosition" : {
      "x" : 415,
      "y" : 845
    },
    "connectors" : [ ]
  }, {
    "id" : 43786,
    "reactomeId" : 10631450,
    "displayName" : "RUNX1:CBFB",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 551,
      "y" : 676
    },
    "minX" : 510,
    "maxX" : 598,
    "minY" : 659,
    "maxY" : 687,
    "prop" : {
      "x" : 510,
      "y" : 665,
      "width" : 82,
      "height" : 22
    },
    "textPosition" : {
      "x" : 524,
      "y" : 652
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 592,
          "y" : 665
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 592,
          "y" : 665
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 43783,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 43787,
    "reactomeId" : 10631454,
    "displayName" : "RUNX1:CCND3,(CCND1,CCND2)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 715,
      "y" : 856
    },
    "minX" : 610,
    "maxX" : 776,
    "minY" : 630,
    "maxY" : 873,
    "prop" : {
      "x" : 661,
      "y" : 840,
      "width" : 109,
      "height" : 33
    },
    "textPosition" : {
      "x" : 662,
      "y" : 838
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 770,
          "y" : 840
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 770,
          "y" : 840
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 43783,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 707,
          "y" : 837
        },
        "to" : {
          "x" : 614,
          "y" : 632
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 610,
          "y" : 634
        },
        "b" : {
          "x" : 618,
          "y" : 630
        },
        "c" : {
          "x" : 614,
          "y" : 632
        },
        "type" : "STOP",
        "centre" : {
          "x" : 614,
          "y" : 632
        }
      }
    }, {
      "edgeId" : 43788,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 43789,
    "reactomeId" : 10631452,
    "displayName" : "CCND3,(CCND1,CCND2)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 803,
      "y" : 780
    },
    "minX" : 693,
    "maxX" : 845,
    "minY" : 713,
    "maxY" : 805,
    "prop" : {
      "x" : 761,
      "y" : 755,
      "width" : 84,
      "height" : 50
    },
    "textPosition" : {
      "x" : 773,
      "y" : 755
    },
    "connectors" : [ {
      "edgeId" : 43788,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 761,
          "y" : 749
        },
        "to" : {
          "x" : 693,
          "y" : 713
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 43779,
    "reactomeId" : 10633471,
    "displayName" : "CDK6 binds RUNX1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 462,
      "y" : 608
    },
    "minX" : 456,
    "maxX" : 468,
    "minY" : 583,
    "maxY" : 739,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 461,
        "y" : 583
      },
      "to" : {
        "x" : 462,
        "y" : 608
      }
    }, {
      "from" : {
        "x" : 462,
        "y" : 608
      },
      "to" : {
        "x" : 462,
        "y" : 739
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 458,
        "y" : 732
      },
      "b" : {
        "x" : 462,
        "y" : 739
      },
      "c" : {
        "x" : 466,
        "y" : 732
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 466,
        "y" : 732
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 462,
        "y" : 608
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 462,
        "y" : 608
      }
    },
    "inputs" : [ {
      "id" : 43780,
      "points" : [ {
        "x" : 421,
        "y" : 578
      } ]
    }, {
      "id" : 43781,
      "points" : [ {
        "x" : 465,
        "y" : 545
      } ]
    } ],
    "outputs" : [ {
      "id" : 43782
    } ]
  }, {
    "id" : 43783,
    "reactomeId" : 10631456,
    "displayName" : "CBFB binds RUNX1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 610,
      "y" : 624
    },
    "minX" : 563,
    "maxX" : 677,
    "minY" : 613,
    "maxY" : 662,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 677,
        "y" : 613
      },
      "to" : {
        "x" : 610,
        "y" : 624
      }
    }, {
      "from" : {
        "x" : 610,
        "y" : 624
      },
      "to" : {
        "x" : 563,
        "y" : 662
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 566,
        "y" : 655
      },
      "b" : {
        "x" : 563,
        "y" : 662
      },
      "c" : {
        "x" : 571,
        "y" : 661
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 571,
        "y" : 661
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 610,
        "y" : 624
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 610,
        "y" : 624
      }
    },
    "inputs" : [ {
      "id" : 43784,
      "points" : [ {
        "x" : 616,
        "y" : 583
      } ]
    }, {
      "id" : 43785,
      "points" : [ {
        "x" : 714,
        "y" : 566
      } ]
    } ],
    "outputs" : [ {
      "id" : 43786
    } ],
    "inhibitors" : [ {
      "id" : 43787,
      "points" : [ {
        "x" : 707,
        "y" : 837
      } ]
    } ]
  }, {
    "id" : 43788,
    "reactomeId" : 10633473,
    "displayName" : "CCND3,(CCND1,CCND2) binds RUNX1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 714,
      "y" : 774
    },
    "minX" : 693,
    "maxX" : 720,
    "minY" : 713,
    "maxY" : 837,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 693,
        "y" : 713
      },
      "to" : {
        "x" : 714,
        "y" : 774
      }
    }, {
      "from" : {
        "x" : 714,
        "y" : 774
      },
      "to" : {
        "x" : 714,
        "y" : 837
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 710,
        "y" : 830
      },
      "b" : {
        "x" : 714,
        "y" : 837
      },
      "c" : {
        "x" : 718,
        "y" : 830
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 718,
        "y" : 830
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 714,
        "y" : 774
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 714,
        "y" : 774
      }
    },
    "inputs" : [ {
      "id" : 43789,
      "points" : [ {
        "x" : 761,
        "y" : 749
      } ]
    }, {
      "id" : 43785,
      "points" : [ {
        "x" : 720,
        "y" : 566
      } ]
    } ],
    "outputs" : [ {
      "id" : 43787
    } ]
  } ],
  "compartments" : [ {
    "id" : 43790,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 871,
      "y" : 532
    },
    "minX" : 0,
    "maxX" : 1742,
    "minY" : 0,
    "maxY" : 1065,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1742,
      "height" : 1065
    },
    "textPosition" : {
      "x" : 61,
      "y" : 975
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1722,
      "height" : 1045
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 43791 ]
  }, {
    "id" : 43791,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 899,
      "y" : 734
    },
    "minX" : 204,
    "maxX" : 1595,
    "minY" : 465,
    "maxY" : 1003,
    "prop" : {
      "x" : 204,
      "y" : 465,
      "width" : 1391,
      "height" : 538
    },
    "textPosition" : {
      "x" : 223,
      "y" : 935
    },
    "insets" : {
      "x" : 214,
      "y" : 475,
      "width" : 1371,
      "height" : 518
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 43785, 43779, 43786, 43780, 43782, 43781, 43803, 43804, 43783, 43784, 43788, 43789, 43787, 43801, 43805 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 43803,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 613,
      "y" : 540
    },
    "minX" : 537,
    "maxX" : 690,
    "minY" : 533,
    "maxY" : 548,
    "segments" : [ {
      "from" : {
        "x" : 690,
        "y" : 548
      },
      "to" : {
        "x" : 537,
        "y" : 533
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 607,
        "y" : 534
      },
      "b" : {
        "x" : 619,
        "y" : 546
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 613,
        "y" : 540
      }
    },
    "inputs" : [ {
      "id" : 43785
    } ],
    "outputs" : [ {
      "id" : 43781
    } ]
  }, {
    "id" : 43804,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 508,
      "y" : 603
    },
    "minX" : 473,
    "maxX" : 544,
    "minY" : 545,
    "maxY" : 662,
    "segments" : [ {
      "from" : {
        "x" : 544,
        "y" : 662
      },
      "to" : {
        "x" : 473,
        "y" : 545
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 502,
        "y" : 597
      },
      "b" : {
        "x" : 514,
        "y" : 609
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 508,
        "y" : 603
      }
    },
    "inputs" : [ {
      "id" : 43786
    } ],
    "outputs" : [ {
      "id" : 43781
    } ]
  }, {
    "id" : 43805,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 535,
      "y" : 758
    },
    "minX" : 522,
    "maxX" : 548,
    "minY" : 690,
    "maxY" : 826,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 548,
        "y" : 690
      },
      "to" : {
        "x" : 522,
        "y" : 826
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 519,
        "y" : 818
      },
      "b" : {
        "x" : 522,
        "y" : 826
      },
      "c" : {
        "x" : 527,
        "y" : 820
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 527,
        "y" : 820
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 529,
        "y" : 752
      },
      "b" : {
        "x" : 541,
        "y" : 764
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 535,
        "y" : 758
      }
    },
    "inputs" : [ {
      "id" : 43786
    } ],
    "outputs" : [ {
      "id" : 43801
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1742,
  "minY" : 0,
  "maxY" : 1065,
  "disease" : false
}