{
  "dbId" : 10647530,
  "stId" : "R-DRE-70635",
  "speciesName" : "Danio rerio",
  "nodes" : [ {
    "dbId" : 10587618,
    "stId" : "R-DRE-452025",
    "displayName" : "ARG2 [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6PH54",
    "standardIdentifier" : "uniprot:Q6PH54",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10587620 ],
    "children" : [ ]
  }, {
    "dbId" : 10587620,
    "stId" : "R-DRE-452013",
    "displayName" : "ARG2 trimer [mitochondrial matrix]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 87597 ],
    "parents" : [ ],
    "children" : [ 113527, 10587618 ]
  }, {
    "dbId" : 30471,
    "stId" : "R-ALL-30471",
    "displayName" : "NAcGlu [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87572 ],
    "identifier" : "17533",
    "standardIdentifier" : "chebi:17533",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29514,
    "stId" : "R-ALL-29514",
    "displayName" : "Urea [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87589 ],
    "identifier" : "16199",
    "standardIdentifier" : "chebi:16199",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113548,
    "stId" : "R-ALL-113548",
    "displayName" : "Pi [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87580 ],
    "identifier" : "43474",
    "standardIdentifier" : "chebi:43474",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 34575,
    "stId" : "R-ALL-34575",
    "displayName" : "ARSUA [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87583 ],
    "identifier" : "57472",
    "standardIdentifier" : "chebi:57472",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29968,
    "stId" : "R-ALL-29968",
    "displayName" : "L-Cit [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87600 ],
    "identifier" : "57743",
    "standardIdentifier" : "chebi:57743",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113552,
    "stId" : "R-ALL-113552",
    "displayName" : "L-Glu [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87571 ],
    "identifier" : "29985",
    "standardIdentifier" : "chebi:29985",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29586,
    "stId" : "R-ALL-29586",
    "displayName" : "FUMA [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87585 ],
    "identifier" : "29806",
    "standardIdentifier" : "chebi:29806",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10561460,
    "stId" : "R-DRE-70618",
    "displayName" : "slc25a15a [mitochondrial inner membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A1L288",
    "standardIdentifier" : "uniprot:A1L288",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "slc25a15a" ],
    "parents" : [ 10561468, 10561466 ],
    "children" : [ ]
  }, {
    "dbId" : 113559,
    "stId" : "R-ALL-113559",
    "displayName" : "Ac-CoA [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87570 ],
    "identifier" : "57288",
    "standardIdentifier" : "chebi:57288",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10561464,
    "stId" : "R-DRE-374020",
    "displayName" : "slc25a15b [mitochondrial inner membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A2BEN9",
    "standardIdentifier" : "uniprot:A2BEN9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "slc25a15b" ],
    "parents" : [ 10561466 ],
    "children" : [ ]
  }, {
    "dbId" : 10647161,
    "stId" : "R-DRE-9956408",
    "displayName" : "otc [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 87604 ],
    "identifier" : "E9QHD9",
    "standardIdentifier" : "uniprot:E9QHD9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "otc" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10561466,
    "stId" : "R-DRE-374020-2",
    "displayName" : "Homologues of SLC25A2 [mitochondrial inner membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "parents" : [ 10561468 ],
    "children" : [ 10561464, 10561460 ]
  }, {
    "dbId" : 70106,
    "stId" : "R-ALL-70106",
    "displayName" : "H+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87601 ],
    "identifier" : "15378",
    "standardIdentifier" : "chebi:15378",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29468,
    "stId" : "R-ALL-29468",
    "displayName" : "L-Arg [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87584 ],
    "identifier" : "32682",
    "standardIdentifier" : "chebi:32682",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10561468,
    "stId" : "R-DRE-374018",
    "displayName" : "Mitochondrial ornithine transporters [mitochondrial inner membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "diagramIds" : [ 87602 ],
    "parents" : [ ],
    "children" : [ 10561466, 10561460 ]
  }, {
    "dbId" : 113567,
    "stId" : "R-ALL-113567",
    "displayName" : "L-Cit [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87579 ],
    "identifier" : "57743",
    "standardIdentifier" : "chebi:57743",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10561346,
    "stId" : "R-DRE-70528",
    "displayName" : "NAGS(19-534) [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "E7FCP8",
    "standardIdentifier" : "uniprot:E7FCP8",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10561348 ],
    "children" : [ ]
  }, {
    "dbId" : 10561348,
    "stId" : "R-DRE-9955687",
    "displayName" : "NAGS(19-534) dimer [mitochondrial matrix]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 87574 ],
    "parents" : [ ],
    "children" : [ 10561346 ]
  }, {
    "dbId" : 374061,
    "stId" : "R-ALL-374061",
    "displayName" : "Urea [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87595 ],
    "identifier" : "16199",
    "standardIdentifier" : "chebi:16199",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10561355,
    "stId" : "R-DRE-70557",
    "displayName" : "otc [mitochondrial matrix]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "E9QHD9",
    "standardIdentifier" : "uniprot:E9QHD9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "otc" ],
    "parents" : [ 10561357 ],
    "children" : [ ]
  }, {
    "dbId" : 29418,
    "stId" : "R-ALL-29418",
    "displayName" : "Mn2+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29035",
    "standardIdentifier" : "chebi:29035",
    "chebiIdentifier" : "chebi:29035",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10561366 ],
    "children" : [ ]
  }, {
    "dbId" : 10561357,
    "stId" : "R-DRE-70558",
    "displayName" : "OTC trimer [mitochondrial matrix]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 87581 ],
    "parents" : [ ],
    "children" : [ 10561355 ]
  }, {
    "dbId" : 29676,
    "stId" : "R-ALL-29676",
    "displayName" : "CAP [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87577 ],
    "identifier" : "58228",
    "standardIdentifier" : "chebi:58228",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29356,
    "stId" : "R-ALL-29356",
    "displayName" : "H2O [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87588 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113585,
    "stId" : "R-ALL-113585",
    "displayName" : "L-Orn [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87578, 87596 ],
    "identifier" : "46911",
    "standardIdentifier" : "chebi:46911",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113521,
    "stId" : "R-ALL-113521",
    "displayName" : "H2O [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87593 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 374064,
    "stId" : "R-ALL-374064",
    "displayName" : "L-Arg [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87575, 87594 ],
    "identifier" : "32682",
    "standardIdentifier" : "chebi:32682",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10561364,
    "stId" : "R-DRE-70561",
    "displayName" : "ARG1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "E7F8R4",
    "standardIdentifier" : "uniprot:E7F8R4",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10561366 ],
    "children" : [ ]
  }, {
    "dbId" : 113527,
    "stId" : "R-ALL-113527",
    "displayName" : "Mn2+ [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29035",
    "standardIdentifier" : "chebi:29035",
    "chebiIdentifier" : "chebi:29035",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10587620 ],
    "children" : [ ]
  }, {
    "dbId" : 10561366,
    "stId" : "R-DRE-70567",
    "displayName" : "ARG1 trimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 87591 ],
    "parents" : [ ],
    "children" : [ 29418, 10561364 ]
  }, {
    "dbId" : 113529,
    "stId" : "R-ALL-113529",
    "displayName" : "H+ [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87599 ],
    "identifier" : "15378",
    "standardIdentifier" : "chebi:15378",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29498,
    "stId" : "R-ALL-29498",
    "displayName" : "L-Orn [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87590 ],
    "identifier" : "46911",
    "standardIdentifier" : "chebi:46911",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10561373,
    "stId" : "R-DRE-70570",
    "displayName" : "asl [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "F1RA91",
    "standardIdentifier" : "uniprot:F1RA91",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "asl" ],
    "parents" : [ 10561375 ],
    "children" : [ ]
  }, {
    "dbId" : 10561375,
    "stId" : "R-DRE-70571",
    "displayName" : "ASL tetramer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 87586 ],
    "parents" : [ ],
    "children" : [ 10561373 ]
  }, {
    "dbId" : 29374,
    "stId" : "R-ALL-29374",
    "displayName" : "CoA-SH [mitochondrial matrix]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 87573 ],
    "identifier" : "57287",
    "standardIdentifier" : "chebi:57287",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10561360,
    "stId" : "R-DRE-70560",
    "displayName" : "carbamoyl phosphate + ornithine => citrulline + orthophosphate",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10561471, 10647163 ],
    "following" : [ 10561471 ],
    "inputs" : [ 29676, 113585 ],
    "outputs" : [ 113567, 113548 ],
    "catalysts" : [ 10561357 ],
    "efs" : [ ],
    "diagramIds" : [ 87576 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10561378,
    "stId" : "R-DRE-70573",
    "displayName" : "argininosuccinate <=> fumarate + arginine",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10561369 ],
    "inputs" : [ 34575 ],
    "outputs" : [ 29468, 29586 ],
    "catalysts" : [ 10561375 ],
    "efs" : [ ],
    "diagramIds" : [ 87582 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10561351,
    "stId" : "R-DRE-70542",
    "displayName" : "glutamate + acetyl CoA => N-acetyl glutamate + CoA",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 113559, 113552 ],
    "outputs" : [ 29374, 30471 ],
    "catalysts" : [ 10561348 ],
    "efs" : [ ],
    "activators" : [ 374064 ],
    "diagramIds" : [ 87569 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10587623,
    "stId" : "R-DRE-452036",
    "displayName" : "arginine + H2O => ornithine + urea [ARG2]",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 374064, 113521 ],
    "outputs" : [ 374061, 113585 ],
    "catalysts" : [ 10587620 ],
    "efs" : [ ],
    "diagramIds" : [ 87592 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10561369,
    "stId" : "R-DRE-70569",
    "displayName" : "arginine + H2O => ornithine + urea [ARG1]",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10561378 ],
    "following" : [ 10561471 ],
    "inputs" : [ 29356, 29468 ],
    "outputs" : [ 29514, 29498 ],
    "catalysts" : [ 10561366 ],
    "efs" : [ ],
    "diagramIds" : [ 87587 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10647163,
    "stId" : "R-DRE-9956502",
    "displayName" : "OTC precursor is targeted to the mitochondrial matrix and processed",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "following" : [ 10561360 ],
    "inputs" : [ 10647161 ],
    "outputs" : [ 10561357 ],
    "efs" : [ ],
    "diagramIds" : [ 87603 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10561471,
    "stId" : "R-DRE-70634",
    "displayName" : "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10561369, 10561360 ],
    "following" : [ 10561360 ],
    "inputs" : [ 113567, 29498, 113529 ],
    "outputs" : [ 70106, 113585, 29968 ],
    "catalysts" : [ 10561468 ],
    "efs" : [ ],
    "diagramIds" : [ 87598 ],
    "entityFunctionalStatus" : [ ]
  } ]
}