{ "dbId" : 10648880, "stableId" : "R-DRE-373755", "displayName" : "Semaphorin interactions", "nodes" : [ { "id" : 13184, "reactomeId" : 9686558, "displayName" : "ROCKi", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 3292, "y" : 408 }, "minX" : 3218, "maxX" : 3323, "minY" : 397, "maxY" : 419, "prop" : { "x" : 3262, "y" : 397, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 3271, "y" : 397 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 13183, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3256, "y" : 408 }, "to" : { "x" : 3218, "y" : 408 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13097, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2314, "y" : 263 }, "minX" : 2295, "maxX" : 2343, "minY" : 207, "maxY" : 278, "prop" : { "x" : 2295, "y" : 248, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 2299, "y" : 252 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2329, "y" : 253 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2329, "y" : 253 } } }, "connectors" : [ { "edgeId" : 13096, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2321, "y" : 245 }, "to" : { "x" : 2343, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13098, "reactomeId" : 10579377, "displayName" : "Plexin-B1:ErbB2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2246, "y" : 208 }, "minX" : 2193, "maxX" : 2388, "minY" : 143, "maxY" : 219, "prop" : { "x" : 2193, "y" : 197, "width" : 106, "height" : 22 }, "textPosition" : { "x" : 2193, "y" : 198 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2299, "y" : 197 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2299, "y" : 197 } } }, "connectors" : [ { "edgeId" : 13096, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2302, "y" : 207 }, "to" : { "x" : 2343, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13096, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2246, "y" : 194 }, "to" : { "x" : 2246, "y" : 143 } }, { "from" : { "x" : 2246, "y" : 143 }, "to" : { "x" : 2384, "y" : 143 } }, { "from" : { "x" : 2384, "y" : 143 }, "to" : { "x" : 2384, "y" : 191 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2384, "y" : 195 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2384, "y" : 195 } } } ] }, { "id" : 13099, "reactomeId" : 10579367, "displayName" : "SEMA4D dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2225, "y" : 82 }, "minX" : 2176, "maxX" : 2343, "minY" : 65, "maxY" : 207, "prop" : { "x" : 2176, "y" : 71, "width" : 99, "height" : 22 }, "textPosition" : { "x" : 2176, "y" : 72 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2275, "y" : 71 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2275, "y" : 71 } } }, "connectors" : [ { "edgeId" : 13096, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2235, "y" : 96 }, "to" : { "x" : 2343, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13100, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2459, "y" : 262 }, "minX" : 2412, "maxX" : 2480, "minY" : 207, "maxY" : 277, "prop" : { "x" : 2439, "y" : 247, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2442, "y" : 251 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2474, "y" : 252 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2474, "y" : 252 } } }, "connectors" : [ { "edgeId" : 13096, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2446, "y" : 244 }, "to" : { "x" : 2412, "y" : 207 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2438, "y" : 242 }, "b" : { "x" : 2446, "y" : 244 }, "c" : { "x" : 2444, "y" : 236 }, "type" : "ARROW", "centre" : { "x" : 2444, "y" : 236 } } } ] }, { "id" : 13101, "reactomeId" : 10579384, "displayName" : "SEMA4D:ERBB2:p-Y-PLXNB1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2524, "y" : 207 }, "minX" : 2412, "maxX" : 2594, "minY" : 183, "maxY" : 225, "prop" : { "x" : 2460, "y" : 189, "width" : 128, "height" : 36 }, "textPosition" : { "x" : 2464, "y" : 190 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2588, "y" : 189 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2588, "y" : 189 } } }, "connectors" : [ { "edgeId" : 13096, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2457, "y" : 207 }, "to" : { "x" : 2412, "y" : 207 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2450, "y" : 211 }, "b" : { "x" : 2457, "y" : 207 }, "c" : { "x" : 2450, "y" : 203 }, "type" : "ARROW", "centre" : { "x" : 2450, "y" : 203 } } } ] }, { "id" : 13103, "reactomeId" : 10583841, "displayName" : "SEMA4D:ERBB2:p-Y-PLXNB1:RND1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2712, "y" : 208 }, "minX" : 2649, "maxX" : 2837, "minY" : 182, "maxY" : 228, "prop" : { "x" : 2649, "y" : 188, "width" : 126, "height" : 40 }, "textPosition" : { "x" : 2652, "y" : 193 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2775, "y" : 188 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2775, "y" : 188 } } }, "connectors" : [ { "edgeId" : 13102, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2778, "y" : 206 }, "to" : { "x" : 2837, "y" : 206 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13104, "reactomeId" : 10583843, "displayName" : "ARHGEF11,ARHGEF12", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2744, "y" : 287 }, "minX" : 2695, "maxX" : 2837, "minY" : 206, "maxY" : 305, "prop" : { "x" : 2695, "y" : 269, "width" : 99, "height" : 36 }, "textPosition" : { "x" : 2706, "y" : 269 }, "connectors" : [ { "edgeId" : 13102, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2764, "y" : 263 }, "to" : { "x" : 2837, "y" : 206 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13105, "reactomeId" : 10583845, "displayName" : "SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3008, "y" : 208 }, "minX" : 2909, "maxX" : 3113, "minY" : 184, "maxY" : 299, "prop" : { "x" : 2909, "y" : 190, "width" : 198, "height" : 36 }, "textPosition" : { "x" : 2918, "y" : 191 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3107, "y" : 190 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3107, "y" : 190 } } }, "connectors" : [ { "edgeId" : 13102, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13106, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3007, "y" : 229 }, "to" : { "x" : 3004, "y" : 291 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3004, "y" : 295 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3004, "y" : 295 } } } ] }, { "id" : 13107, "reactomeId" : 10583837, "displayName" : "RhoA,B,C:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2929, "y" : 337 }, "minX" : 2882, "maxX" : 2983, "minY" : 307, "maxY" : 348, "prop" : { "x" : 2882, "y" : 326, "width" : 95, "height" : 22 }, "textPosition" : { "x" : 2882, "y" : 327 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2977, "y" : 326 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2977, "y" : 326 } } }, "connectors" : [ { "edgeId" : 13106, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2946, "y" : 323 }, "to" : { "x" : 2977, "y" : 307 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13108, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2920, "y" : 279 }, "minX" : 2900, "maxX" : 2977, "minY" : 263, "maxY" : 307, "prop" : { "x" : 2900, "y" : 264, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2904, "y" : 268 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2935, "y" : 269 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2935, "y" : 269 } } }, "connectors" : [ { "edgeId" : 13106, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2943, "y" : 288 }, "to" : { "x" : 2977, "y" : 307 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13109, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3074, "y" : 279 }, "minX" : 3025, "maxX" : 3096, "minY" : 263, "maxY" : 307, "prop" : { "x" : 3054, "y" : 264, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 3057, "y" : 268 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3090, "y" : 269 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3090, "y" : 269 } } }, "connectors" : [ { "edgeId" : 13106, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3051, "y" : 290 }, "to" : { "x" : 3025, "y" : 307 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3047, "y" : 297 }, "b" : { "x" : 3051, "y" : 290 }, "c" : { "x" : 3043, "y" : 290 }, "type" : "ARROW", "centre" : { "x" : 3043, "y" : 290 } } } ] }, { "id" : 13110, "reactomeId" : 10583839, "displayName" : "RHOA/B/C:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3077, "y" : 340 }, "minX" : 3025, "maxX" : 3133, "minY" : 307, "maxY" : 411, "prop" : { "x" : 3028, "y" : 326, "width" : 99, "height" : 28 }, "textPosition" : { "x" : 3030, "y" : 333 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3127, "y" : 326 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3127, "y" : 326 } } }, "connectors" : [ { "edgeId" : 13106, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3054, "y" : 323 }, "to" : { "x" : 3025, "y" : 307 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3046, "y" : 323 }, "b" : { "x" : 3054, "y" : 323 }, "c" : { "x" : 3050, "y" : 316 }, "type" : "ARROW", "centre" : { "x" : 3050, "y" : 316 } } }, { "edgeId" : 13111, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3068, "y" : 357 }, "to" : { "x" : 3032, "y" : 411 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13112, "reactomeId" : 10584203, "displayName" : "ROCK2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3136, "y" : 384 }, "minX" : 3032, "maxX" : 3218, "minY" : 364, "maxY" : 411, "prop" : { "x" : 3103, "y" : 370, "width" : 66, "height" : 29 }, "textPosition" : { "x" : 3112, "y" : 374 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3169, "y" : 370 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3169, "y" : 370 } } }, "connectors" : [ { "edgeId" : 13111, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3097, "y" : 392 }, "to" : { "x" : 3032, "y" : 411 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13183, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3175, "y" : 393 }, "to" : { "x" : 3218, "y" : 408 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13113, "reactomeId" : 10584205, "displayName" : "Activated ROCK:RhoA/B/C:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3032, "y" : 506 }, "minX" : 2979, "maxX" : 3092, "minY" : 482, "maxY" : 524, "prop" : { "x" : 2979, "y" : 488, "width" : 107, "height" : 36 }, "textPosition" : { "x" : 2979, "y" : 489 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3086, "y" : 488 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3086, "y" : 488 } } }, "connectors" : [ { "edgeId" : 13111, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13114, "reactomeId" : 10584207, "displayName" : "ROCK1,ROCK2:ROCKi", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 3122, "y" : 442 }, "minX" : 3041, "maxX" : 3178, "minY" : 418, "maxY" : 460, "prop" : { "x" : 3073, "y" : 424, "width" : 99, "height" : 36 }, "textPosition" : { "x" : 3074, "y" : 425 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3172, "y" : 424 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3172, "y" : 424 } } }, "connectors" : [ { "edgeId" : 13111, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 3070, "y" : 442 }, "to" : { "x" : 3041, "y" : 443 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3041, "y" : 439 }, "b" : { "x" : 3041, "y" : 447 }, "c" : { "x" : 3041, "y" : 443 }, "type" : "STOP", "centre" : { "x" : 3041, "y" : 443 } } }, { "edgeId" : 13183, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13116, "reactomeId" : 10579367, "displayName" : "SEMA4D dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 621, "y" : 81 }, "minX" : 572, "maxX" : 677, "minY" : 64, "maxY" : 207, "prop" : { "x" : 572, "y" : 70, "width" : 99, "height" : 22 }, "textPosition" : { "x" : 572, "y" : 71 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 671, "y" : 70 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 671, "y" : 70 } } }, "connectors" : [ { "edgeId" : 13115, "type" : "INPUT", "segments" : [ { "from" : { "x" : 623, "y" : 95 }, "to" : { "x" : 649, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13117, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 600, "y" : 257 }, "minX" : 581, "maxX" : 649, "minY" : 207, "maxY" : 272, "prop" : { "x" : 581, "y" : 242, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 585, "y" : 246 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 615, "y" : 247 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 615, "y" : 247 } } }, "connectors" : [ { "edgeId" : 13115, "type" : "INPUT", "segments" : [ { "from" : { "x" : 614, "y" : 239 }, "to" : { "x" : 649, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13118, "reactomeId" : 10584244, "displayName" : "Plexin-B1:Met", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 577, "y" : 208 }, "minX" : 531, "maxX" : 689, "minY" : 167, "maxY" : 219, "prop" : { "x" : 531, "y" : 197, "width" : 92, "height" : 22 }, "textPosition" : { "x" : 531, "y" : 198 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 623, "y" : 197 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 623, "y" : 197 } } }, "connectors" : [ { "edgeId" : 13115, "type" : "INPUT", "segments" : [ { "from" : { "x" : 626, "y" : 207 }, "to" : { "x" : 649, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13115, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 576, "y" : 194 }, "to" : { "x" : 576, "y" : 167 } }, { "from" : { "x" : 576, "y" : 167 }, "to" : { "x" : 684, "y" : 167 } }, { "from" : { "x" : 684, "y" : 167 }, "to" : { "x" : 685, "y" : 191 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 685, "y" : 195 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 685, "y" : 195 } } } ] }, { "id" : 13119, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 771, "y" : 255 }, "minX" : 717, "maxX" : 792, "minY" : 207, "maxY" : 270, "prop" : { "x" : 751, "y" : 240, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 754, "y" : 244 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 786, "y" : 245 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 786, "y" : 245 } } }, "connectors" : [ { "edgeId" : 13115, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 754, "y" : 237 }, "to" : { "x" : 717, "y" : 207 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 746, "y" : 236 }, "b" : { "x" : 754, "y" : 237 }, "c" : { "x" : 751, "y" : 230 }, "type" : "ARROW", "centre" : { "x" : 751, "y" : 230 } } } ] }, { "id" : 13120, "reactomeId" : 10583783, "displayName" : "SEMA4D:MET:p-Y-PLXNB1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 836, "y" : 208 }, "minX" : 717, "maxX" : 1148, "minY" : 170, "maxY" : 226, "prop" : { "x" : 772, "y" : 190, "width" : 128, "height" : 36 }, "textPosition" : { "x" : 778, "y" : 191 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 900, "y" : 190 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 900, "y" : 190 } } }, "connectors" : [ { "edgeId" : 13121, "type" : "INPUT", "segments" : [ { "from" : { "x" : 903, "y" : 207 }, "to" : { "x" : 932, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13124, "type" : "INPUT", "segments" : [ { "from" : { "x" : 853, "y" : 187 }, "to" : { "x" : 872, "y" : 170 } }, { "from" : { "x" : 872, "y" : 170 }, "to" : { "x" : 1122, "y" : 170 } }, { "from" : { "x" : 1122, "y" : 170 }, "to" : { "x" : 1148, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13115, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 769, "y" : 207 }, "to" : { "x" : 717, "y" : 207 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 762, "y" : 211 }, "b" : { "x" : 769, "y" : 207 }, "c" : { "x" : 762, "y" : 203 }, "type" : "ARROW", "centre" : { "x" : 762, "y" : 203 } } } ] }, { "id" : 13122, "reactomeId" : 10567498, "displayName" : "RAC1:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 866, "y" : 265 }, "minX" : 831, "maxX" : 932, "minY" : 207, "maxY" : 276, "prop" : { "x" : 831, "y" : 254, "width" : 71, "height" : 22 }, "textPosition" : { "x" : 832, "y" : 255 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 902, "y" : 254 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 902, "y" : 254 } } }, "connectors" : [ { "edgeId" : 13121, "type" : "INPUT", "segments" : [ { "from" : { "x" : 878, "y" : 251 }, "to" : { "x" : 932, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13123, "reactomeId" : 10583789, "displayName" : "Sema4D:pPlexin-B1:Met:RAC1-GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1064, "y" : 208 }, "minX" : 1000, "maxX" : 1134, "minY" : 184, "maxY" : 226, "prop" : { "x" : 1000, "y" : 190, "width" : 128, "height" : 36 }, "textPosition" : { "x" : 1006, "y" : 191 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1128, "y" : 190 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1128, "y" : 190 } } }, "connectors" : [ { "edgeId" : 13121, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13125, "reactomeId" : 10583775, "displayName" : "RND1:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1095, "y" : 263 }, "minX" : 1060, "maxX" : 1148, "minY" : 207, "maxY" : 274, "prop" : { "x" : 1060, "y" : 252, "width" : 70, "height" : 22 }, "textPosition" : { "x" : 1060, "y" : 253 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1130, "y" : 252 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1130, "y" : 252 } } }, "connectors" : [ { "edgeId" : 13124, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1105, "y" : 249 }, "to" : { "x" : 1148, "y" : 207 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13126, "reactomeId" : 10583785, "displayName" : "SEMA4D:MET:p-Y-PLXNB1:RND1:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1302, "y" : 207 }, "minX" : 1238, "maxX" : 1498, "minY" : 154, "maxY" : 280, "prop" : { "x" : 1238, "y" : 189, "width" : 128, "height" : 36 }, "textPosition" : { "x" : 1242, "y" : 190 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1366, "y" : 189 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1366, "y" : 189 } } }, "connectors" : [ { "edgeId" : 13124, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13127, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1301, "y" : 186 }, "to" : { "x" : 1301, "y" : 154 } }, { "from" : { "x" : 1301, "y" : 154 }, "to" : { "x" : 1494, "y" : 154 } }, { "from" : { "x" : 1494, "y" : 154 }, "to" : { "x" : 1494, "y" : 190 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1494, "y" : 194 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1494, "y" : 194 } } }, { "edgeId" : 13131, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1307, "y" : 228 }, "to" : { "x" : 1325, "y" : 280 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13128, "reactomeId" : 10583809, "displayName" : "R-Ras-GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1427, "y" : 208 }, "minX" : 1390, "maxX" : 1471, "minY" : 191, "maxY" : 219, "prop" : { "x" : 1390, "y" : 197, "width" : 75, "height" : 22 }, "textPosition" : { "x" : 1392, "y" : 198 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1465, "y" : 197 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1465, "y" : 197 } } }, "connectors" : [ { "edgeId" : 13127, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13129, "reactomeId" : 10583811, "displayName" : "R-Ras-GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1588, "y" : 208 }, "minX" : 1513, "maxX" : 1632, "minY" : 191, "maxY" : 219, "prop" : { "x" : 1550, "y" : 197, "width" : 76, "height" : 22 }, "textPosition" : { "x" : 1551, "y" : 198 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1626, "y" : 197 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1626, "y" : 197 } } }, "connectors" : [ { "edgeId" : 13127, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1547, "y" : 206 }, "to" : { "x" : 1513, "y" : 206 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1540, "y" : 210 }, "b" : { "x" : 1547, "y" : 206 }, "c" : { "x" : 1540, "y" : 202 }, "type" : "ARROW", "centre" : { "x" : 1540, "y" : 202 } } } ] }, { "id" : 13130, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1525, "y" : 251 }, "minX" : 1508, "maxX" : 1544, "minY" : 206, "maxY" : 264, "prop" : { "x" : 1508, "y" : 239, "width" : 35, "height" : 25 }, "textPosition" : { "x" : 1516, "y" : 241 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1538, "y" : 244 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1538, "y" : 244 } } }, "connectors" : [ { "edgeId" : 13127, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1521, "y" : 236 }, "to" : { "x" : 1513, "y" : 206 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1515, "y" : 230 }, "b" : { "x" : 1521, "y" : 236 }, "c" : { "x" : 1523, "y" : 228 }, "type" : "ARROW", "centre" : { "x" : 1523, "y" : 228 } } } ] }, { "id" : 13132, "reactomeId" : 10583818, "displayName" : "arhgap35a", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1291, "y" : 329 }, "minX" : 1240, "maxX" : 1348, "minY" : 280, "maxY" : 347, "prop" : { "x" : 1240, "y" : 311, "width" : 102, "height" : 36 }, "textPosition" : { "x" : 1252, "y" : 318 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1342, "y" : 311 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1342, "y" : 311 } } }, "connectors" : [ { "edgeId" : 13131, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1303, "y" : 308 }, "to" : { "x" : 1325, "y" : 280 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13133, "reactomeId" : 10583820, "displayName" : "SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1717, "y" : 208 }, "minX" : 1657, "maxX" : 1965, "minY" : 149, "maxY" : 233, "prop" : { "x" : 1657, "y" : 183, "width" : 120, "height" : 50 }, "textPosition" : { "x" : 1659, "y" : 184 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1777, "y" : 183 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1777, "y" : 183 } } }, "connectors" : [ { "edgeId" : 13131, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13134, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1717, "y" : 180 }, "to" : { "x" : 1717, "y" : 149 } }, { "from" : { "x" : 1717, "y" : 149 }, "to" : { "x" : 1964, "y" : 149 } }, { "from" : { "x" : 1964, "y" : 149 }, "to" : { "x" : 1961, "y" : 197 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1961, "y" : 201 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1961, "y" : 201 } } } ] }, { "id" : 13135, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1920, "y" : 258 }, "minX" : 1897, "maxX" : 1945, "minY" : 214, "maxY" : 271, "prop" : { "x" : 1897, "y" : 246, "width" : 47, "height" : 25 }, "textPosition" : { "x" : 1903, "y" : 248 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1939, "y" : 251 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1939, "y" : 251 } } }, "connectors" : [ { "edgeId" : 13134, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1924, "y" : 243 }, "to" : { "x" : 1935, "y" : 214 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 13136, "reactomeId" : 10567532, "displayName" : "RHOA:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1857, "y" : 213 }, "minX" : 1816, "maxX" : 1935, "minY" : 195, "maxY" : 225, "prop" : { "x" : 1816, "y" : 201, "width" : 82, "height" : 24 }, "textPosition" : { "x" : 1822, "y" : 204 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1898, "y" : 201 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1898, "y" : 201 } } }, "connectors" : [ { "edgeId" : 13134, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1901, "y" : 213 }, "to" : { "x" : 1935, "y" : 214 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13137, "reactomeId" : 10567530, "displayName" : "RHOA:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2097, "y" : 210 }, "minX" : 1998, "maxX" : 2148, "minY" : 194, "maxY" : 220, "prop" : { "x" : 2053, "y" : 200, "width" : 89, "height" : 20 }, "textPosition" : { "x" : 2061, "y" : 199 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2142, "y" : 200 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2142, "y" : 200 } } }, "connectors" : [ { "edgeId" : 13134, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2050, "y" : 210 }, "to" : { "x" : 1998, "y" : 210 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2043, "y" : 214 }, "b" : { "x" : 2050, "y" : 210 }, "c" : { "x" : 2043, "y" : 206 }, "type" : "ARROW", "centre" : { "x" : 2043, "y" : 206 } } } ] }, { "id" : 13138, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2008, "y" : 263 }, "minX" : 1990, "maxX" : 2027, "minY" : 210, "maxY" : 275, "prop" : { "x" : 1990, "y" : 252, "width" : 36, "height" : 23 }, "textPosition" : { "x" : 1998, "y" : 253 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2021, "y" : 257 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2021, "y" : 257 } } }, "connectors" : [ { "edgeId" : 13134, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2005, "y" : 249 }, "to" : { "x" : 1998, "y" : 210 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2000, "y" : 243 }, "b" : { "x" : 2005, "y" : 249 }, "c" : { "x" : 2008, "y" : 241 }, "type" : "ARROW", "centre" : { "x" : 2008, "y" : 241 } } } ] }, { "id" : 13140, "reactomeId" : 10582572, "displayName" : "PAK2 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1905, "y" : 1023 }, "minX" : 1854, "maxX" : 1967, "minY" : 1006, "maxY" : 1067, "prop" : { "x" : 1854, "y" : 1012, "width" : 103, "height" : 22 }, "textPosition" : { "x" : 1866, "y" : 1012 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1957, "y" : 1012 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1957, "y" : 1012 } } }, "connectors" : [ { "edgeId" : 13139, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1920, "y" : 1040 }, "to" : { "x" : 1967, "y" : 1067 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13141, "reactomeId" : 10583512, "displayName" : "Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1305, "y" : 1119 }, "minX" : 1251, "maxX" : 1967, "minY" : 1067, "maxY" : 1161, "prop" : { "x" : 1251, "y" : 1094, "width" : 108, "height" : 50 }, "textPosition" : { "x" : 1254, "y" : 1095 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1359, "y" : 1094 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1359, "y" : 1094 } } }, "connectors" : [ { "edgeId" : 13139, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1362, "y" : 1129 }, "to" : { "x" : 1521, "y" : 1161 } }, { "from" : { "x" : 1521, "y" : 1161 }, "to" : { "x" : 1907, "y" : 1161 } }, { "from" : { "x" : 1907, "y" : 1161 }, "to" : { "x" : 1967, "y" : 1067 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13142, "reactomeId" : 10583514, "displayName" : "Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2112, "y" : 1105 }, "minX" : 2038, "maxX" : 2238, "minY" : 1067, "maxY" : 1156, "prop" : { "x" : 2053, "y" : 1080, "width" : 118, "height" : 50 }, "textPosition" : { "x" : 2061, "y" : 1081 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2171, "y" : 1080 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2171, "y" : 1080 } } }, "connectors" : [ { "edgeId" : 13139, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2063, "y" : 1077 }, "to" : { "x" : 2038, "y" : 1067 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2055, "y" : 1078 }, "b" : { "x" : 2063, "y" : 1077 }, "c" : { "x" : 2058, "y" : 1071 }, "type" : "ARROW", "centre" : { "x" : 2058, "y" : 1071 } } }, { "edgeId" : 13144, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2174, "y" : 1105 }, "to" : { "x" : 2199, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13144, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2112, "y" : 1133 }, "to" : { "x" : 2112, "y" : 1156 } }, { "from" : { "x" : 2112, "y" : 1156 }, "to" : { "x" : 2234, "y" : 1156 } }, { "from" : { "x" : 2234, "y" : 1156 }, "to" : { "x" : 2234, "y" : 1121 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2234, "y" : 1117 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2234, "y" : 1117 } } } ] }, { "id" : 13143, "reactomeId" : 10582570, "displayName" : "PAK2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2091, "y" : 1023 }, "minX" : 2038, "maxX" : 2131, "minY" : 1002, "maxY" : 1067, "prop" : { "x" : 2058, "y" : 1008, "width" : 67, "height" : 30 }, "textPosition" : { "x" : 2072, "y" : 1012 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2125, "y" : 1008 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2125, "y" : 1008 } } }, "connectors" : [ { "edgeId" : 13139, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2072, "y" : 1044 }, "to" : { "x" : 2038, "y" : 1067 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2069, "y" : 1051 }, "b" : { "x" : 2072, "y" : 1044 }, "c" : { "x" : 2064, "y" : 1045 }, "type" : "ARROW", "centre" : { "x" : 2064, "y" : 1045 } } } ] }, { "id" : 13145, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2162, "y" : 1038 }, "minX" : 2143, "maxX" : 2199, "minY" : 1022, "maxY" : 1105, "prop" : { "x" : 2143, "y" : 1023, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 2147, "y" : 1027 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2177, "y" : 1028 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2177, "y" : 1028 } } }, "connectors" : [ { "edgeId" : 13144, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2170, "y" : 1056 }, "to" : { "x" : 2199, "y" : 1105 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2178, "y" : 1074 }, "b" : { "x" : 2190, "y" : 1086 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2184, "y" : 1080 } } } } ] }, { "id" : 13146, "reactomeId" : 10583544, "displayName" : "Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2351, "y" : 1107 }, "minX" : 2260, "maxX" : 2416, "minY" : 926, "maxY" : 1132, "prop" : { "x" : 2292, "y" : 1082, "width" : 118, "height" : 50 }, "textPosition" : { "x" : 2300, "y" : 1083 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2410, "y" : 1082 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2410, "y" : 1082 } } }, "connectors" : [ { "edgeId" : 13144, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2289, "y" : 1105 }, "to" : { "x" : 2260, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2282, "y" : 1109 }, "b" : { "x" : 2289, "y" : 1105 }, "c" : { "x" : 2282, "y" : 1101 }, "type" : "ARROW", "centre" : { "x" : 2282, "y" : 1101 } } }, { "edgeId" : 13148, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2350, "y" : 1079 }, "to" : { "x" : 2350, "y" : 934 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2350, "y" : 930 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2350, "y" : 930 } } } ] }, { "id" : 13147, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2300, "y" : 1038 }, "minX" : 2260, "maxX" : 2321, "minY" : 1022, "maxY" : 1105, "prop" : { "x" : 2280, "y" : 1023, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2283, "y" : 1027 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2315, "y" : 1028 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2315, "y" : 1028 } } }, "connectors" : [ { "edgeId" : 13144, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2291, "y" : 1056 }, "to" : { "x" : 2260, "y" : 1105 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2269, "y" : 1074 }, "b" : { "x" : 2281, "y" : 1086 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2275, "y" : 1080 } } }, "endShape" : { "a" : { "x" : 2291, "y" : 1064 }, "b" : { "x" : 2291, "y" : 1056 }, "c" : { "x" : 2284, "y" : 1060 }, "type" : "ARROW", "centre" : { "x" : 2284, "y" : 1060 } } } ] }, { "id" : 13149, "reactomeId" : 10583630, "displayName" : "LIMK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2288, "y" : 876 }, "minX" : 2254, "maxX" : 2329, "minY" : 854, "maxY" : 918, "prop" : { "x" : 2254, "y" : 860, "width" : 69, "height" : 33 }, "textPosition" : { "x" : 2267, "y" : 866 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2323, "y" : 860 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2323, "y" : 860 } } }, "connectors" : [ { "edgeId" : 13148, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2295, "y" : 896 }, "to" : { "x" : 2308, "y" : 918 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13150, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2273, "y" : 959 }, "minX" : 2254, "maxX" : 2308, "minY" : 918, "maxY" : 974, "prop" : { "x" : 2254, "y" : 944, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 2258, "y" : 948 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2288, "y" : 949 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2288, "y" : 949 } } }, "connectors" : [ { "edgeId" : 13148, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2285, "y" : 941 }, "to" : { "x" : 2308, "y" : 918 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13151, "reactomeId" : 10583633, "displayName" : "phospho-p-T508-LIMK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2426, "y" : 871 }, "minX" : 2375, "maxX" : 2483, "minY" : 725, "maxY" : 918, "prop" : { "x" : 2375, "y" : 860, "width" : 102, "height" : 22 }, "textPosition" : { "x" : 2386, "y" : 854 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2477, "y" : 860 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2477, "y" : 860 } } }, "connectors" : [ { "edgeId" : 13153, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2428, "y" : 857 }, "to" : { "x" : 2454, "y" : 725 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 2435, "y" : 785 }, "b" : { "x" : 2447, "y" : 797 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2441, "y" : 791 } } } }, { "edgeId" : 13148, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2414, "y" : 885 }, "to" : { "x" : 2376, "y" : 918 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2411, "y" : 893 }, "b" : { "x" : 2414, "y" : 885 }, "c" : { "x" : 2406, "y" : 887 }, "type" : "ARROW", "centre" : { "x" : 2406, "y" : 887 } } } ] }, { "id" : 13152, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2441, "y" : 958 }, "minX" : 2376, "maxX" : 2462, "minY" : 918, "maxY" : 973, "prop" : { "x" : 2421, "y" : 943, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2424, "y" : 947 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2456, "y" : 948 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2456, "y" : 948 } } }, "connectors" : [ { "edgeId" : 13148, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2418, "y" : 945 }, "to" : { "x" : 2376, "y" : 918 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2410, "y" : 945 }, "b" : { "x" : 2418, "y" : 945 }, "c" : { "x" : 2414, "y" : 938 }, "type" : "ARROW", "centre" : { "x" : 2414, "y" : 938 } } } ] }, { "id" : 13154, "reactomeId" : 10584230, "displayName" : "HSP90AA1,HSP90AB1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 2378, "y" : 730 }, "minX" : 2337, "maxX" : 2454, "minY" : 640, "maxY" : 748, "prop" : { "x" : 2337, "y" : 713, "width" : 82, "height" : 35 }, "textPosition" : { "x" : 2339, "y" : 713 }, "connectors" : [ { "edgeId" : 13153, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2425, "y" : 727 }, "to" : { "x" : 2454, "y" : 725 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13156, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2384, "y" : 707 }, "to" : { "x" : 2409, "y" : 640 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2383, "y" : 699 }, "b" : { "x" : 2384, "y" : 707 }, "c" : { "x" : 2390, "y" : 702 }, "type" : "ARROW", "centre" : { "x" : 2390, "y" : 702 } } } ] }, { "id" : 13155, "reactomeId" : 10584232, "displayName" : "pLIMK dimer:HSP-90", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2557, "y" : 642 }, "minX" : 2430, "maxX" : 2628, "minY" : 625, "maxY" : 671, "prop" : { "x" : 2492, "y" : 631, "width" : 130, "height" : 22 }, "textPosition" : { "x" : 2492, "y" : 632 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2622, "y" : 631 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2622, "y" : 631 } } }, "connectors" : [ { "edgeId" : 13153, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13156, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2489, "y" : 640 }, "to" : { "x" : 2462, "y" : 640 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13156, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2509, "y" : 656 }, "to" : { "x" : 2432, "y" : 671 } }, { "from" : { "x" : 2432, "y" : 671 }, "to" : { "x" : 2433, "y" : 656 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2434, "y" : 652 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2434, "y" : 652 } } } ] }, { "id" : 13157, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2532, "y" : 587 }, "minX" : 2462, "maxX" : 2553, "minY" : 571, "maxY" : 640, "prop" : { "x" : 2513, "y" : 572, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 2517, "y" : 576 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2547, "y" : 577 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2547, "y" : 577 } } }, "connectors" : [ { "edgeId" : 13156, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2510, "y" : 601 }, "to" : { "x" : 2462, "y" : 640 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13158, "reactomeId" : 10584237, "displayName" : "Active LIMK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2331, "y" : 642 }, "minX" : 2289, "maxX" : 2409, "minY" : 625, "maxY" : 653, "prop" : { "x" : 2289, "y" : 631, "width" : 84, "height" : 22 }, "textPosition" : { "x" : 2289, "y" : 632 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2373, "y" : 631 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2373, "y" : 631 } } }, "connectors" : [ { "edgeId" : 13156, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2376, "y" : 640 }, "to" : { "x" : 2409, "y" : 640 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2383, "y" : 636 }, "b" : { "x" : 2376, "y" : 640 }, "c" : { "x" : 2383, "y" : 644 }, "type" : "ARROW", "centre" : { "x" : 2383, "y" : 644 } } } ] }, { "id" : 13159, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2373, "y" : 594 }, "minX" : 2353, "maxX" : 2409, "minY" : 578, "maxY" : 640, "prop" : { "x" : 2353, "y" : 579, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 2356, "y" : 583 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2388, "y" : 584 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2388, "y" : 584 } } }, "connectors" : [ { "edgeId" : 13156, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2384, "y" : 612 }, "to" : { "x" : 2409, "y" : 640 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2392, "y" : 615 }, "b" : { "x" : 2384, "y" : 612 }, "c" : { "x" : 2386, "y" : 620 }, "type" : "ARROW", "centre" : { "x" : 2386, "y" : 620 } } } ] }, { "id" : 13161, "reactomeId" : 10583577, "displayName" : "Sema3A:Nrp-1:PlexinA:Fyn:pCdk5", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2981, "y" : 1112 }, "minX" : 2921, "maxX" : 3132, "minY" : 1088, "maxY" : 1146, "prop" : { "x" : 2921, "y" : 1094, "width" : 121, "height" : 36 }, "textPosition" : { "x" : 2921, "y" : 1095 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3042, "y" : 1094 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3042, "y" : 1094 } } }, "connectors" : [ { "edgeId" : 13160, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3045, "y" : 1112 }, "to" : { "x" : 3086, "y" : 1112 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 13160, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2980, "y" : 1133 }, "to" : { "x" : 2980, "y" : 1146 } }, { "from" : { "x" : 2980, "y" : 1146 }, "to" : { "x" : 3127, "y" : 1145 } }, { "from" : { "x" : 3127, "y" : 1145 }, "to" : { "x" : 3128, "y" : 1128 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3128, "y" : 1124 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3128, "y" : 1124 } } } ] }, { "id" : 13162, "reactomeId" : 10583559, "displayName" : "CRMP's tetramers", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3066, "y" : 1036 }, "minX" : 3007, "maxX" : 3132, "minY" : 1019, "maxY" : 1112, "prop" : { "x" : 3007, "y" : 1025, "width" : 119, "height" : 22 }, "textPosition" : { "x" : 3007, "y" : 1026 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3126, "y" : 1025 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3126, "y" : 1025 } } }, "connectors" : [ { "edgeId" : 13160, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3068, "y" : 1050 }, "to" : { "x" : 3086, "y" : 1112 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13163, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2990, "y" : 1054 }, "minX" : 2971, "maxX" : 3086, "minY" : 1038, "maxY" : 1112, "prop" : { "x" : 2971, "y" : 1039, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 2975, "y" : 1043 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3005, "y" : 1044 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3005, "y" : 1044 } } }, "connectors" : [ { "edgeId" : 13160, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3013, "y" : 1065 }, "to" : { "x" : 3086, "y" : 1112 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 3043, "y" : 1082 }, "b" : { "x" : 3055, "y" : 1094 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3049, "y" : 1088 } } } } ] }, { "id" : 13164, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3208, "y" : 1051 }, "minX" : 3163, "maxX" : 3229, "minY" : 1035, "maxY" : 1113, "prop" : { "x" : 3188, "y" : 1036, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 3191, "y" : 1040 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3223, "y" : 1041 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3223, "y" : 1041 } } }, "connectors" : [ { "edgeId" : 13160, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3197, "y" : 1069 }, "to" : { "x" : 3163, "y" : 1113 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 3174, "y" : 1085 }, "b" : { "x" : 3186, "y" : 1097 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3180, "y" : 1091 } } }, "endShape" : { "a" : { "x" : 3196, "y" : 1077 }, "b" : { "x" : 3197, "y" : 1069 }, "c" : { "x" : 3190, "y" : 1072 }, "type" : "ARROW", "centre" : { "x" : 3190, "y" : 1072 } } } ] }, { "id" : 13165, "reactomeId" : 10583593, "displayName" : "Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3260, "y" : 1113 }, "minX" : 3163, "maxX" : 3369, "minY" : 1082, "maxY" : 1138, "prop" : { "x" : 3204, "y" : 1088, "width" : 112, "height" : 50 }, "textPosition" : { "x" : 3209, "y" : 1089 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3316, "y" : 1088 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3316, "y" : 1088 } } }, "connectors" : [ { "edgeId" : 13160, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3201, "y" : 1113 }, "to" : { "x" : 3163, "y" : 1113 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3194, "y" : 1117 }, "b" : { "x" : 3201, "y" : 1113 }, "c" : { "x" : 3194, "y" : 1109 }, "type" : "ARROW", "centre" : { "x" : 3194, "y" : 1109 } } }, { "edgeId" : 13166, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3319, "y" : 1113 }, "to" : { "x" : 3369, "y" : 1113 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13167, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3326, "y" : 1044 }, "minX" : 3307, "maxX" : 3369, "minY" : 1028, "maxY" : 1113, "prop" : { "x" : 3307, "y" : 1029, "width" : 39, "height" : 30 }, "textPosition" : { "x" : 3311, "y" : 1033 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3341, "y" : 1034 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3341, "y" : 1034 } } }, "connectors" : [ { "edgeId" : 13166, "type" : "INPUT", "segments" : [ { "from" : { "x" : 3335, "y" : 1062 }, "to" : { "x" : 3369, "y" : 1113 } } ], "stoichiometry" : { "value" : 9, "shape" : { "a" : { "x" : 3346, "y" : 1081 }, "b" : { "x" : 3358, "y" : 1093 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3352, "y" : 1087 } } } } ] }, { "id" : 13168, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 3455, "y" : 1037 }, "minX" : 3432, "maxX" : 3476, "minY" : 1021, "maxY" : 1113, "prop" : { "x" : 3435, "y" : 1022, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 3438, "y" : 1026 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3470, "y" : 1027 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3470, "y" : 1027 } } }, "connectors" : [ { "edgeId" : 13166, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3450, "y" : 1055 }, "to" : { "x" : 3432, "y" : 1113 } } ], "stoichiometry" : { "value" : 9, "shape" : { "a" : { "x" : 3435, "y" : 1078 }, "b" : { "x" : 3447, "y" : 1090 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3441, "y" : 1084 } } }, "endShape" : { "a" : { "x" : 3452, "y" : 1063 }, "b" : { "x" : 3450, "y" : 1055 }, "c" : { "x" : 3444, "y" : 1060 }, "type" : "ARROW", "centre" : { "x" : 3444, "y" : 1060 } } } ] }, { "id" : 13169, "reactomeId" : 10583623, "displayName" : "Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 3531, "y" : 1112 }, "minX" : 3432, "maxX" : 3595, "minY" : 1080, "maxY" : 1139, "prop" : { "x" : 3474, "y" : 1086, "width" : 115, "height" : 53 }, "textPosition" : { "x" : 3481, "y" : 1090 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3589, "y" : 1086 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3589, "y" : 1086 } } }, "connectors" : [ { "edgeId" : 13166, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 3471, "y" : 1112 }, "to" : { "x" : 3432, "y" : 1113 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 3464, "y" : 1116 }, "b" : { "x" : 3471, "y" : 1112 }, "c" : { "x" : 3464, "y" : 1108 }, "type" : "ARROW", "centre" : { "x" : 3464, "y" : 1108 } } } ] }, { "id" : 13170, "reactomeId" : 10574008, "displayName" : "GSK3B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 3399, "y" : 1020 }, "minX" : 3375, "maxX" : 3430, "minY" : 1003, "maxY" : 1105, "prop" : { "x" : 3375, "y" : 1009, "width" : 49, "height" : 22 }, "textPosition" : { "x" : 3375, "y" : 1009 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 3424, "y" : 1009 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3424, "y" : 1009 } } }, "connectors" : [ { "edgeId" : 13166, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 3399, "y" : 1034 }, "to" : { "x" : 3400, "y" : 1097 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 3400, "y" : 1101 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 3400, "y" : 1101 } } } ] }, { "id" : 13172, "reactomeId" : 10583904, "displayName" : "plxnd1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 4578, "y" : 209 }, "minX" : 4540, "maxX" : 4651, "minY" : 193, "maxY" : 220, "prop" : { "x" : 4540, "y" : 199, "width" : 76, "height" : 21 }, "textPosition" : { "x" : 4553, "y" : 199 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4616, "y" : 199 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4616, "y" : 199 } } }, "connectors" : [ { "edgeId" : 13171, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4619, "y" : 209 }, "to" : { "x" : 4651, "y" : 210 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13173, "reactomeId" : 10583900, "displayName" : "sema3e", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 4651, "y" : 88 }, "minX" : 4619, "maxX" : 4690, "minY" : 71, "maxY" : 210, "prop" : { "x" : 4619, "y" : 77, "width" : 65, "height" : 22 }, "textPosition" : { "x" : 4622, "y" : 77 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4684, "y" : 77 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4684, "y" : 77 } } }, "connectors" : [ { "edgeId" : 13171, "type" : "INPUT", "segments" : [ { "from" : { "x" : 4651, "y" : 102 }, "to" : { "x" : 4651, "y" : 210 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13174, "reactomeId" : 10583906, "displayName" : "SEMA3A:PLXND1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 4776, "y" : 211 }, "minX" : 4718, "maxX" : 4840, "minY" : 193, "maxY" : 223, "prop" : { "x" : 4718, "y" : 199, "width" : 116, "height" : 24 }, "textPosition" : { "x" : 4721, "y" : 202 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 4834, "y" : 199 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 4834, "y" : 199 } } }, "connectors" : [ { "edgeId" : 13171, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13176, "reactomeId" : 10583918, "displayName" : "Homologues of SEMA4A", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 5595, "y" : 290 }, "minX" : 5440, "maxX" : 5629, "minY" : 278, "maxY" : 303, "prop" : { "x" : 5562, "y" : 278, "width" : 67, "height" : 25 }, "textPosition" : { "x" : 5564, "y" : 266 }, "connectors" : [ { "edgeId" : 13175, "type" : "INPUT", "segments" : [ { "from" : { "x" : 5559, "y" : 289 }, "to" : { "x" : 5440, "y" : 289 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13177, "reactomeId" : 10583904, "displayName" : "plxnd1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 5440, "y" : 242 }, "minX" : 5409, "maxX" : 5478, "minY" : 225, "maxY" : 289, "prop" : { "x" : 5409, "y" : 231, "width" : 63, "height" : 22 }, "textPosition" : { "x" : 5416, "y" : 231 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5472, "y" : 231 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5472, "y" : 231 } } }, "connectors" : [ { "edgeId" : 13175, "type" : "INPUT", "segments" : [ { "from" : { "x" : 5440, "y" : 256 }, "to" : { "x" : 5440, "y" : 289 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13178, "reactomeId" : 10583920, "displayName" : "SEMA4A:PLXND1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 5440, "y" : 369 }, "minX" : 5382, "maxX" : 5505, "minY" : 352, "maxY" : 380, "prop" : { "x" : 5382, "y" : 358, "width" : 117, "height" : 22 }, "textPosition" : { "x" : 5386, "y" : 359 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 5499, "y" : 358 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 5499, "y" : 358 } } }, "connectors" : [ { "edgeId" : 13175, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13180, "reactomeId" : 10583934, "displayName" : "Homologues of PLXNB3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 253, "y" : 331 }, "minX" : 221, "maxX" : 285, "minY" : 320, "maxY" : 371, "prop" : { "x" : 221, "y" : 320, "width" : 64, "height" : 22 }, "textPosition" : { "x" : 221, "y" : 307 }, "connectors" : [ { "edgeId" : 13179, "type" : "INPUT", "segments" : [ { "from" : { "x" : 252, "y" : 345 }, "to" : { "x" : 252, "y" : 371 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13181, "reactomeId" : 10583926, "displayName" : "sema5a", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 109, "y" : 432 }, "minX" : 80, "maxX" : 252, "minY" : 371, "maxY" : 443, "prop" : { "x" : 80, "y" : 421, "width" : 59, "height" : 22 }, "textPosition" : { "x" : 80, "y" : 421 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 139, "y" : 421 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 139, "y" : 421 } } }, "connectors" : [ { "edgeId" : 13179, "type" : "INPUT", "segments" : [ { "from" : { "x" : 134, "y" : 418 }, "to" : { "x" : 252, "y" : 371 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 13182, "reactomeId" : 10583936, "displayName" : "SEMA5A:PLXNB3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 252, "y" : 437 }, "minX" : 195, "maxX" : 316, "minY" : 420, "maxY" : 448, "prop" : { "x" : 195, "y" : 426, "width" : 115, "height" : 22 }, "textPosition" : { "x" : 198, "y" : 427 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 310, "y" : 426 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 310, "y" : 426 } } }, "connectors" : [ { "edgeId" : 13179, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 13121, "reactomeId" : 10583791, "displayName" : "Active Rac1 interacts with Plexin-B1:Sema4D", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 962, "y" : 207 }, "minX" : 932, "maxX" : 997, "minY" : 201, "maxY" : 213, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 932, "y" : 207 }, "to" : { "x" : 962, "y" : 207 } }, { "from" : { "x" : 962, "y" : 207 }, "to" : { "x" : 997, "y" : 207 } } ], "endShape" : { "a" : { "x" : 990, "y" : 211 }, "b" : { "x" : 997, "y" : 207 }, "c" : { "x" : 990, "y" : 203 }, "type" : "ARROW", "centre" : { "x" : 990, "y" : 203 } }, "reactionShape" : { "c" : { "x" : 962, "y" : 207 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 962, "y" : 207 } }, "inputs" : [ { "id" : 13120, "points" : [ { "x" : 903, "y" : 207 } ] }, { "id" : 13122, "points" : [ { "x" : 878, "y" : 251 } ] } ], "outputs" : [ { "id" : 13123 } ] }, { "id" : 13153, "reactomeId" : 10584242, "displayName" : "Dimerization of LIMK1 by Hsp90", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2554, "y" : 689 }, "minX" : 2454, "maxX" : 2560, "minY" : 656, "maxY" : 725, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2454, "y" : 725 }, "to" : { "x" : 2554, "y" : 689 } }, { "from" : { "x" : 2554, "y" : 689 }, "to" : { "x" : 2556, "y" : 656 } } ], "endShape" : { "a" : { "x" : 2560, "y" : 663 }, "b" : { "x" : 2556, "y" : 656 }, "c" : { "x" : 2552, "y" : 663 }, "type" : "ARROW", "centre" : { "x" : 2552, "y" : 663 } }, "reactionShape" : { "c" : { "x" : 2554, "y" : 689 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2554, "y" : 689 } }, "inputs" : [ { "id" : 13154, "points" : [ { "x" : 2425, "y" : 727 } ] }, { "id" : 13151, "points" : [ { "x" : 2428, "y" : 857 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 13155 } ] }, { "id" : 13124, "reactomeId" : 10583787, "displayName" : "Rnd1 interacts with Plexin-B1:Sema4D", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1185, "y" : 207 }, "minX" : 1148, "maxX" : 1235, "minY" : 201, "maxY" : 213, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1148, "y" : 207 }, "to" : { "x" : 1185, "y" : 207 } }, { "from" : { "x" : 1185, "y" : 207 }, "to" : { "x" : 1235, "y" : 207 } } ], "endShape" : { "a" : { "x" : 1228, "y" : 211 }, "b" : { "x" : 1235, "y" : 207 }, "c" : { "x" : 1228, "y" : 203 }, "type" : "ARROW", "centre" : { "x" : 1228, "y" : 203 } }, "reactionShape" : { "c" : { "x" : 1185, "y" : 207 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1185, "y" : 207 } }, "inputs" : [ { "id" : 13120, "points" : [ { "x" : 853, "y" : 187 }, { "x" : 872, "y" : 170 }, { "x" : 1122, "y" : 170 } ] }, { "id" : 13125, "points" : [ { "x" : 1105, "y" : 249 } ] } ], "outputs" : [ { "id" : 13126 } ] }, { "id" : 13156, "reactomeId" : 10584240, "displayName" : "Transphosphorylation of pLIMK1", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2435, "y" : 640 }, "minX" : 2409, "maxX" : 2462, "minY" : 634, "maxY" : 646, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2462, "y" : 640 }, "to" : { "x" : 2435, "y" : 640 } }, { "from" : { "x" : 2435, "y" : 640 }, "to" : { "x" : 2409, "y" : 640 } } ], "reactionShape" : { "a" : { "x" : 2429, "y" : 634 }, "b" : { "x" : 2441, "y" : 646 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2435, "y" : 640 } }, "inputs" : [ { "id" : 13155, "points" : [ { "x" : 2489, "y" : 640 } ] }, { "id" : 13157, "points" : [ { "x" : 2510, "y" : 601 } ] } ], "outputs" : [ { "id" : 13154, "points" : [ { "x" : 2384, "y" : 707 } ] }, { "id" : 13158, "points" : [ { "x" : 2376, "y" : 640 } ] }, { "id" : 13159, "points" : [ { "x" : 2384, "y" : 612 } ] } ], "catalysts" : [ { "id" : 13155, "points" : [ { "x" : 2509, "y" : 656 }, { "x" : 2432, "y" : 671 } ] } ] }, { "id" : 13127, "reactomeId" : 10583814, "displayName" : "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1494, "y" : 206 }, "minX" : 1468, "maxX" : 1513, "minY" : 200, "maxY" : 212, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1468, "y" : 206 }, "to" : { "x" : 1494, "y" : 206 } }, { "from" : { "x" : 1494, "y" : 206 }, "to" : { "x" : 1513, "y" : 206 } } ], "reactionShape" : { "a" : { "x" : 1488, "y" : 200 }, "b" : { "x" : 1500, "y" : 212 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1494, "y" : 206 } }, "inputs" : [ { "id" : 13128 } ], "outputs" : [ { "id" : 13129, "points" : [ { "x" : 1547, "y" : 206 } ] }, { "id" : 13130, "points" : [ { "x" : 1521, "y" : 236 } ] } ], "catalysts" : [ { "id" : 13126, "points" : [ { "x" : 1301, "y" : 186 }, { "x" : 1301, "y" : 154 }, { "x" : 1494, "y" : 154 } ] } ] }, { "id" : 13160, "reactomeId" : 10583596, "displayName" : "Phosphorylation of CRMPs by Cdk5", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3129, "y" : 1112 }, "minX" : 3086, "maxX" : 3163, "minY" : 1106, "maxY" : 1118, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3086, "y" : 1112 }, "to" : { "x" : 3129, "y" : 1112 } }, { "from" : { "x" : 3129, "y" : 1112 }, "to" : { "x" : 3163, "y" : 1113 } } ], "reactionShape" : { "a" : { "x" : 3123, "y" : 1106 }, "b" : { "x" : 3135, "y" : 1118 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3129, "y" : 1112 } }, "inputs" : [ { "id" : 13161, "points" : [ { "x" : 3045, "y" : 1112 } ] }, { "id" : 13162, "points" : [ { "x" : 3068, "y" : 1050 } ] }, { "id" : 13163, "points" : [ { "x" : 3013, "y" : 1065 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 13164, "points" : [ { "x" : 3197, "y" : 1069 } ], "stoichiometry" : 4 }, { "id" : 13165, "points" : [ { "x" : 3201, "y" : 1113 } ] } ], "catalysts" : [ { "id" : 13161, "points" : [ { "x" : 2980, "y" : 1133 }, { "x" : 2980, "y" : 1146 }, { "x" : 3127, "y" : 1145 } ] } ] }, { "id" : 13096, "reactomeId" : 10579387, "displayName" : "SEMA4D interacts with Plexin-B1:ErbB2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2384, "y" : 207 }, "minX" : 2343, "maxX" : 2412, "minY" : 201, "maxY" : 213, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2343, "y" : 207 }, "to" : { "x" : 2384, "y" : 207 } }, { "from" : { "x" : 2384, "y" : 207 }, "to" : { "x" : 2412, "y" : 207 } } ], "reactionShape" : { "a" : { "x" : 2378, "y" : 201 }, "b" : { "x" : 2390, "y" : 213 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2384, "y" : 207 } }, "inputs" : [ { "id" : 13097, "points" : [ { "x" : 2321, "y" : 245 } ] }, { "id" : 13098, "points" : [ { "x" : 2302, "y" : 207 } ] }, { "id" : 13099, "points" : [ { "x" : 2235, "y" : 96 } ] } ], "outputs" : [ { "id" : 13100, "points" : [ { "x" : 2446, "y" : 244 } ] }, { "id" : 13101, "points" : [ { "x" : 2457, "y" : 207 } ] } ], "catalysts" : [ { "id" : 13098, "points" : [ { "x" : 2246, "y" : 194 }, { "x" : 2246, "y" : 143 }, { "x" : 2384, "y" : 143 } ] } ] }, { "id" : 13131, "reactomeId" : 10583825, "displayName" : "p190RhoGAP binds Plexin-B1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1546, "y" : 280 }, "minX" : 1325, "maxX" : 1657, "minY" : 236, "maxY" : 286, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1325, "y" : 280 }, "to" : { "x" : 1546, "y" : 280 } }, { "from" : { "x" : 1546, "y" : 280 }, "to" : { "x" : 1657, "y" : 236 } } ], "endShape" : { "a" : { "x" : 1652, "y" : 242 }, "b" : { "x" : 1657, "y" : 236 }, "c" : { "x" : 1649, "y" : 235 }, "type" : "ARROW", "centre" : { "x" : 1649, "y" : 235 } }, "reactionShape" : { "c" : { "x" : 1546, "y" : 280 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1546, "y" : 280 } }, "inputs" : [ { "id" : 13132, "points" : [ { "x" : 1303, "y" : 308 } ] }, { "id" : 13126, "points" : [ { "x" : 1307, "y" : 228 } ] } ], "outputs" : [ { "id" : 13133 } ] }, { "id" : 13166, "reactomeId" : 10583626, "displayName" : "Phosphorylation of CRMPs by GSK3beta", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3400, "y" : 1113 }, "minX" : 3369, "maxX" : 3432, "minY" : 1107, "maxY" : 1119, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 3369, "y" : 1113 }, "to" : { "x" : 3400, "y" : 1113 } }, { "from" : { "x" : 3400, "y" : 1113 }, "to" : { "x" : 3432, "y" : 1113 } } ], "reactionShape" : { "a" : { "x" : 3394, "y" : 1107 }, "b" : { "x" : 3406, "y" : 1119 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3400, "y" : 1113 } }, "inputs" : [ { "id" : 13165, "points" : [ { "x" : 3319, "y" : 1113 } ] }, { "id" : 13167, "points" : [ { "x" : 3335, "y" : 1062 } ], "stoichiometry" : 9 } ], "outputs" : [ { "id" : 13168, "points" : [ { "x" : 3450, "y" : 1055 } ], "stoichiometry" : 9 }, { "id" : 13169, "points" : [ { "x" : 3471, "y" : 1112 } ] } ], "catalysts" : [ { "id" : 13170, "points" : [ { "x" : 3399, "y" : 1034 } ] } ] }, { "id" : 13102, "reactomeId" : 10583850, "displayName" : "LARG and PDZ-RhoGEF binds to Plexin-B1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2864, "y" : 206 }, "minX" : 2837, "maxX" : 2906, "minY" : 200, "maxY" : 212, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2837, "y" : 206 }, "to" : { "x" : 2864, "y" : 206 } }, { "from" : { "x" : 2864, "y" : 206 }, "to" : { "x" : 2906, "y" : 206 } } ], "endShape" : { "a" : { "x" : 2899, "y" : 210 }, "b" : { "x" : 2906, "y" : 206 }, "c" : { "x" : 2899, "y" : 202 }, "type" : "ARROW", "centre" : { "x" : 2899, "y" : 202 } }, "reactionShape" : { "c" : { "x" : 2864, "y" : 206 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2864, "y" : 206 } }, "inputs" : [ { "id" : 13103, "points" : [ { "x" : 2778, "y" : 206 } ] }, { "id" : 13104, "points" : [ { "x" : 2764, "y" : 263 } ] } ], "outputs" : [ { "id" : 13105 } ] }, { "id" : 13134, "reactomeId" : 10583823, "displayName" : "Inactivation of Rho-GTP by p190RhoGAP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1960, "y" : 213 }, "minX" : 1935, "maxX" : 1998, "minY" : 207, "maxY" : 219, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1935, "y" : 214 }, "to" : { "x" : 1960, "y" : 213 } }, { "from" : { "x" : 1960, "y" : 213 }, "to" : { "x" : 1998, "y" : 210 } } ], "reactionShape" : { "a" : { "x" : 1954, "y" : 207 }, "b" : { "x" : 1966, "y" : 219 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1960, "y" : 213 } }, "inputs" : [ { "id" : 13135, "points" : [ { "x" : 1924, "y" : 243 } ] }, { "id" : 13136, "points" : [ { "x" : 1901, "y" : 213 } ] } ], "outputs" : [ { "id" : 13137, "points" : [ { "x" : 2050, "y" : 210 } ] }, { "id" : 13138, "points" : [ { "x" : 2005, "y" : 249 } ] } ], "catalysts" : [ { "id" : 13133, "points" : [ { "x" : 1717, "y" : 180 }, { "x" : 1717, "y" : 149 }, { "x" : 1964, "y" : 149 } ] } ] }, { "id" : 13106, "reactomeId" : 10583848, "displayName" : "Activation of Rho by LARG and PDZ-RhoGEF", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3003, "y" : 307 }, "minX" : 2977, "maxX" : 3025, "minY" : 301, "maxY" : 313, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2977, "y" : 307 }, "to" : { "x" : 3003, "y" : 307 } }, { "from" : { "x" : 3003, "y" : 307 }, "to" : { "x" : 3025, "y" : 307 } } ], "reactionShape" : { "a" : { "x" : 2997, "y" : 301 }, "b" : { "x" : 3009, "y" : 313 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 3003, "y" : 307 } }, "inputs" : [ { "id" : 13107, "points" : [ { "x" : 2946, "y" : 323 } ] }, { "id" : 13108, "points" : [ { "x" : 2943, "y" : 288 } ] } ], "outputs" : [ { "id" : 13109, "points" : [ { "x" : 3051, "y" : 290 } ] }, { "id" : 13110, "points" : [ { "x" : 3054, "y" : 323 } ] } ], "catalysts" : [ { "id" : 13105, "points" : [ { "x" : 3007, "y" : 229 } ] } ] }, { "id" : 13171, "reactomeId" : 10583908, "displayName" : "SEMA3E binds to PLXND1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 4680, "y" : 210 }, "minX" : 4651, "maxX" : 4715, "minY" : 204, "maxY" : 216, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 4651, "y" : 210 }, "to" : { "x" : 4680, "y" : 210 } }, { "from" : { "x" : 4680, "y" : 210 }, "to" : { "x" : 4715, "y" : 210 } } ], "endShape" : { "a" : { "x" : 4708, "y" : 214 }, "b" : { "x" : 4715, "y" : 210 }, "c" : { "x" : 4708, "y" : 206 }, "type" : "ARROW", "centre" : { "x" : 4708, "y" : 206 } }, "reactionShape" : { "c" : { "x" : 4680, "y" : 210 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 4680, "y" : 210 } }, "inputs" : [ { "id" : 13172, "points" : [ { "x" : 4619, "y" : 209 } ] }, { "id" : 13173, "points" : [ { "x" : 4651, "y" : 102 } ] } ], "outputs" : [ { "id" : 13174 } ] }, { "id" : 13139, "reactomeId" : 10583516, "displayName" : "Activation of PAK by Rac1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2002, "y" : 1067 }, "minX" : 1967, "maxX" : 2038, "minY" : 1061, "maxY" : 1073, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1967, "y" : 1067 }, "to" : { "x" : 2002, "y" : 1067 } }, { "from" : { "x" : 2002, "y" : 1067 }, "to" : { "x" : 2038, "y" : 1067 } } ], "reactionShape" : { "a" : { "x" : 1996, "y" : 1061 }, "b" : { "x" : 2008, "y" : 1073 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2002, "y" : 1067 } }, "inputs" : [ { "id" : 13140, "points" : [ { "x" : 1920, "y" : 1040 } ] }, { "id" : 13141, "points" : [ { "x" : 1362, "y" : 1129 }, { "x" : 1521, "y" : 1161 }, { "x" : 1907, "y" : 1161 } ] } ], "outputs" : [ { "id" : 13142, "points" : [ { "x" : 2063, "y" : 1077 } ] }, { "id" : 13143, "points" : [ { "x" : 2072, "y" : 1044 } ] } ] }, { "id" : 13111, "reactomeId" : 10584209, "displayName" : "ROCK activation by RHO", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3032, "y" : 443 }, "minX" : 3026, "maxX" : 3038, "minY" : 411, "maxY" : 485, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3032, "y" : 411 }, "to" : { "x" : 3032, "y" : 443 } }, { "from" : { "x" : 3032, "y" : 443 }, "to" : { "x" : 3032, "y" : 485 } } ], "endShape" : { "a" : { "x" : 3028, "y" : 478 }, "b" : { "x" : 3032, "y" : 485 }, "c" : { "x" : 3036, "y" : 478 }, "type" : "ARROW", "centre" : { "x" : 3036, "y" : 478 } }, "reactionShape" : { "c" : { "x" : 3032, "y" : 443 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3032, "y" : 443 } }, "inputs" : [ { "id" : 13112, "points" : [ { "x" : 3097, "y" : 392 } ] }, { "id" : 13110, "points" : [ { "x" : 3068, "y" : 357 } ] } ], "outputs" : [ { "id" : 13113 } ], "inhibitors" : [ { "id" : 13114, "points" : [ { "x" : 3070, "y" : 442 } ] } ] }, { "id" : 13175, "reactomeId" : 10583922, "displayName" : "SEMA4A binds to PLXND1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 5440, "y" : 318 }, "minX" : 5434, "maxX" : 5446, "minY" : 289, "maxY" : 355, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 5440, "y" : 289 }, "to" : { "x" : 5440, "y" : 318 } }, { "from" : { "x" : 5440, "y" : 318 }, "to" : { "x" : 5440, "y" : 355 } } ], "endShape" : { "a" : { "x" : 5436, "y" : 348 }, "b" : { "x" : 5440, "y" : 355 }, "c" : { "x" : 5444, "y" : 348 }, "type" : "ARROW", "centre" : { "x" : 5444, "y" : 348 } }, "reactionShape" : { "c" : { "x" : 5440, "y" : 318 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 5440, "y" : 318 } }, "inputs" : [ { "id" : 13176, "points" : [ { "x" : 5559, "y" : 289 } ] }, { "id" : 13177, "points" : [ { "x" : 5440, "y" : 256 } ] } ], "outputs" : [ { "id" : 13178 } ] }, { "id" : 13144, "reactomeId" : 10583547, "displayName" : "Autophosphorylation of PAK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2234, "y" : 1105 }, "minX" : 2199, "maxX" : 2260, "minY" : 1099, "maxY" : 1111, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2199, "y" : 1105 }, "to" : { "x" : 2234, "y" : 1105 } }, { "from" : { "x" : 2234, "y" : 1105 }, "to" : { "x" : 2260, "y" : 1105 } } ], "reactionShape" : { "a" : { "x" : 2228, "y" : 1099 }, "b" : { "x" : 2240, "y" : 1111 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2234, "y" : 1105 } }, "inputs" : [ { "id" : 13145, "points" : [ { "x" : 2170, "y" : 1056 } ], "stoichiometry" : 2 }, { "id" : 13142, "points" : [ { "x" : 2174, "y" : 1105 } ] } ], "outputs" : [ { "id" : 13146, "points" : [ { "x" : 2289, "y" : 1105 } ] }, { "id" : 13147, "points" : [ { "x" : 2291, "y" : 1056 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 13142, "points" : [ { "x" : 2112, "y" : 1133 }, { "x" : 2112, "y" : 1156 }, { "x" : 2234, "y" : 1156 } ] } ] }, { "id" : 13179, "reactomeId" : 10583938, "displayName" : "SEMA5A binds to PLXNB3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 252, "y" : 392 }, "minX" : 246, "maxX" : 258, "minY" : 371, "maxY" : 423, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 252, "y" : 371 }, "to" : { "x" : 252, "y" : 392 } }, { "from" : { "x" : 252, "y" : 392 }, "to" : { "x" : 252, "y" : 423 } } ], "endShape" : { "a" : { "x" : 248, "y" : 416 }, "b" : { "x" : 252, "y" : 423 }, "c" : { "x" : 256, "y" : 416 }, "type" : "ARROW", "centre" : { "x" : 256, "y" : 416 } }, "reactionShape" : { "c" : { "x" : 252, "y" : 392 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 252, "y" : 392 } }, "inputs" : [ { "id" : 13180, "points" : [ { "x" : 252, "y" : 345 } ] }, { "id" : 13181, "points" : [ { "x" : 134, "y" : 418 } ] } ], "outputs" : [ { "id" : 13182 } ] }, { "id" : 13115, "reactomeId" : 10584247, "displayName" : "SEMA4D interacts with Plexin-B1:Met", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 685, "y" : 207 }, "minX" : 649, "maxX" : 717, "minY" : 201, "maxY" : 213, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 649, "y" : 207 }, "to" : { "x" : 685, "y" : 207 } }, { "from" : { "x" : 685, "y" : 207 }, "to" : { "x" : 717, "y" : 207 } } ], "reactionShape" : { "a" : { "x" : 679, "y" : 201 }, "b" : { "x" : 691, "y" : 213 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 685, "y" : 207 } }, "inputs" : [ { "id" : 13116, "points" : [ { "x" : 623, "y" : 95 } ] }, { "id" : 13117, "points" : [ { "x" : 614, "y" : 239 } ] }, { "id" : 13118, "points" : [ { "x" : 626, "y" : 207 } ] } ], "outputs" : [ { "id" : 13119, "points" : [ { "x" : 754, "y" : 237 } ] }, { "id" : 13120, "points" : [ { "x" : 769, "y" : 207 } ] } ], "catalysts" : [ { "id" : 13118, "points" : [ { "x" : 576, "y" : 194 }, { "x" : 576, "y" : 167 }, { "x" : 684, "y" : 167 } ] } ] }, { "id" : 13148, "reactomeId" : 10583636, "displayName" : "Phosphorylation of LIMK-1 by PAK", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2350, "y" : 918 }, "minX" : 2308, "maxX" : 2376, "minY" : 912, "maxY" : 924, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2308, "y" : 918 }, "to" : { "x" : 2350, "y" : 918 } }, { "from" : { "x" : 2350, "y" : 918 }, "to" : { "x" : 2376, "y" : 918 } } ], "reactionShape" : { "a" : { "x" : 2344, "y" : 912 }, "b" : { "x" : 2356, "y" : 924 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2350, "y" : 918 } }, "inputs" : [ { "id" : 13149, "points" : [ { "x" : 2295, "y" : 896 } ] }, { "id" : 13150, "points" : [ { "x" : 2285, "y" : 941 } ] } ], "outputs" : [ { "id" : 13151, "points" : [ { "x" : 2414, "y" : 885 } ] }, { "id" : 13152, "points" : [ { "x" : 2418, "y" : 945 } ] } ], "catalysts" : [ { "id" : 13146, "points" : [ { "x" : 2350, "y" : 1079 } ] } ] }, { "id" : 13183, "reactomeId" : 10640238, "displayName" : "ROCK1,2 bind ROCKi", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 3219, "y" : 410 }, "minX" : 3175, "maxX" : 3225, "minY" : 404, "maxY" : 425, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 3218, "y" : 408 }, "to" : { "x" : 3219, "y" : 410 } }, { "from" : { "x" : 3219, "y" : 410 }, "to" : { "x" : 3175, "y" : 425 } } ], "endShape" : { "a" : { "x" : 3180, "y" : 419 }, "b" : { "x" : 3175, "y" : 425 }, "c" : { "x" : 3183, "y" : 427 }, "type" : "ARROW", "centre" : { "x" : 3183, "y" : 427 } }, "reactionShape" : { "c" : { "x" : 3219, "y" : 410 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 3219, "y" : 410 } }, "inputs" : [ { "id" : 13184, "points" : [ { "x" : 3256, "y" : 408 } ] }, { "id" : 13112, "points" : [ { "x" : 3175, "y" : 393 } ] } ], "outputs" : [ { "id" : 13114 } ] } ], "compartments" : [ { "id" : 13217, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 58, "y" : 641 }, "minX" : 0, "maxX" : 117, "minY" : 336, "maxY" : 946, "prop" : { "x" : 0, "y" : 336, "width" : 117, "height" : 610 }, "textPosition" : { "x" : 31, "y" : 584 }, "insets" : { "x" : 10, "y" : 346, "width" : 97, "height" : 590 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 13181 ] }, { "id" : 13219, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1452, "y" : 44 }, "minX" : 523, "maxX" : 2382, "minY" : 0, "maxY" : 89, "prop" : { "x" : 523, "y" : 0, "width" : 1859, "height" : 89 }, "textPosition" : { "x" : 1423, "y" : 28 }, "insets" : { "x" : 533, "y" : 10, "width" : 1839, "height" : 69 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 13116, 13099 ] }, { "id" : 13220, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 5621, "y" : 655 }, "minX" : 5573, "maxX" : 5670, "minY" : 205, "maxY" : 1105, "prop" : { "x" : 5573, "y" : 205, "width" : 97, "height" : 900 }, "textPosition" : { "x" : 5592, "y" : 638 }, "insets" : { "x" : 5583, "y" : 215, "width" : 77, "height" : 880 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 13176 ] }, { "id" : 13221, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 4682, "y" : 1257 }, "minX" : 4110, "maxX" : 5254, "minY" : 1198, "maxY" : 1316, "prop" : { "x" : 4110, "y" : 1198, "width" : 1144, "height" : 118 }, "textPosition" : { "x" : 4652, "y" : 1242 }, "insets" : { "x" : 4120, "y" : 1208, "width" : 1124, "height" : 98 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 13215, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2847, "y" : 661 }, "minX" : 248, "maxX" : 5446, "minY" : 202, "maxY" : 1121, "prop" : { "x" : 248, "y" : 202, "width" : 5198, "height" : 919 }, "textPosition" : { "x" : 4098, "y" : 661 }, "insets" : { "x" : 258, "y" : 212, "width" : 5178, "height" : 899 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 13100, 13103, 13104, 13105, 13107, 13108, 13109, 13110, 13112, 13113, 13117, 13118, 13119, 13120, 13123, 13125, 13126, 13122, 13128, 13129, 13130, 13132, 13133, 13141, 13140, 13143, 13145, 13147, 13149, 13150, 13151, 13152, 13154, 13155, 13157, 13158, 13159, 13102, 13106, 13111, 13121, 13124, 13127, 13131, 13134, 13148, 13153, 13156, 13115, 13138, 13223, 13222, 13096, 13101, 13142, 13146, 13139, 13144, 13161, 13162, 13163, 13160, 13165, 13164, 13167, 13166, 13170, 13168, 13169, 13172, 13174, 13171, 13178, 13177, 13175, 13180, 13182, 13179, 13097, 13098, 13136, 13137, 13135, 13114, 13183, 13184 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ { "id" : 13222, "reactomeId" : 10648878, "displayName" : "Sema4D in semaphorin signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1927, "y" : 297 }, "minX" : 521, "maxX" : 3333, "minY" : 60, "maxY" : 534, "prop" : { "x" : 521, "y" : 458, "width" : 2812, "height" : 76 }, "points" : [ { "x" : 521, "y" : 60 }, { "x" : 3333, "y" : 60 }, { "x" : 3333, "y" : 534 }, { "x" : 521, "y" : 534 } ], "colour" : "#4684ee" }, { "id" : 13223, "reactomeId" : 10649018, "displayName" : "Sema3A PAK dependent Axon repulsion", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1936, "y" : 858 }, "minX" : 1241, "maxX" : 2632, "minY" : 562, "maxY" : 1154, "prop" : { "x" : 1241, "y" : 562, "width" : 1391, "height" : 592 }, "points" : [ { "x" : 1241, "y" : 562 }, { "x" : 2632, "y" : 562 }, { "x" : 2632, "y" : 1154 }, { "x" : 1241, "y" : 1154 } ], "colour" : "#dc3912" }, { "id" : 13224, "reactomeId" : 10649020, "displayName" : "CRMPs in Sema3A signaling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 3255, "y" : 1074 }, "minX" : 2911, "maxX" : 3599, "minY" : 999, "maxY" : 1149, "prop" : { "x" : 2911, "y" : 999, "width" : 688, "height" : 150 }, "points" : [ { "x" : 2911, "y" : 999 }, { "x" : 3599, "y" : 999 }, { "x" : 3599, "y" : 1149 }, { "x" : 2911, "y" : 1149 } ], "colour" : "#008000" }, { "id" : 13225, "reactomeId" : 10649038, "displayName" : "Other semaphorin interactions", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2854, "y" : 262 }, "minX" : 70, "maxX" : 5639, "minY" : 67, "maxY" : 458, "prop" : { "x" : 3333, "y" : 67, "width" : 2306, "height" : 391 }, "points" : [ { "x" : 70, "y" : 67 }, { "x" : 5639, "y" : 67 }, { "x" : 5639, "y" : 458 }, { "x" : 70, "y" : 458 } ], "colour" : "#666666" } ], "minX" : 0, "maxX" : 5670, "minY" : 0, "maxY" : 1316, "disease" : false }