{ "dbId" : 10649610, "stableId" : "R-DRE-1834949", "displayName" : "Cytosolic sensors of pathogen-associated DNA ", "nodes" : [ { "id" : 21450, "reactomeId" : 2395973, "displayName" : "c-di-GMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 702, "y" : 293 }, "minX" : 665, "maxX" : 864, "minY" : 277, "maxY" : 319, "prop" : { "x" : 665, "y" : 278, "width" : 74, "height" : 31 }, "textPosition" : { "x" : 671, "y" : 283 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 734, "y" : 283 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 734, "y" : 283 } } }, "connectors" : [ { "edgeId" : 21449, "type" : "INPUT", "segments" : [ { "from" : { "x" : 742, "y" : 298 }, "to" : { "x" : 864, "y" : 319 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21451, "reactomeId" : 10603780, "displayName" : "STING:STING", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1010, "y" : 228 }, "minX" : 864, "maxX" : 1058, "minY" : 211, "maxY" : 319, "prop" : { "x" : 969, "y" : 217, "width" : 83, "height" : 23 }, "textPosition" : { "x" : 986, "y" : 205 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1052, "y" : 217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1052, "y" : 217 } } }, "connectors" : [ { "edgeId" : 21449, "type" : "INPUT", "segments" : [ { "from" : { "x" : 991, "y" : 243 }, "to" : { "x" : 864, "y" : 319 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21453, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21459, "type" : "INPUT", "segments" : [ { "from" : { "x" : 998, "y" : 243 }, "to" : { "x" : 926, "y" : 312 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21452, "reactomeId" : 10603787, "displayName" : "STING:c-di-GMP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 752, "y" : 449 }, "minX" : 700, "maxX" : 811, "minY" : 432, "maxY" : 461, "prop" : { "x" : 700, "y" : 438, "width" : 105, "height" : 23 }, "textPosition" : { "x" : 702, "y" : 440 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 805, "y" : 438 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 805, "y" : 438 } } }, "connectors" : [ { "edgeId" : 21449, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21454, "reactomeId" : 10598584, "displayName" : "STING", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 971, "y" : 104 }, "minX" : 949, "maxX" : 999, "minY" : 75, "maxY" : 153, "prop" : { "x" : 949, "y" : 93, "width" : 44, "height" : 23 }, "textPosition" : { "x" : 949, "y" : 94 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 993, "y" : 93 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 993, "y" : 93 } } }, "connectors" : [ { "edgeId" : 21453, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 953, "y" : 141 }, "b" : { "x" : 965, "y" : 153 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 959, "y" : 147 } } } }, { "edgeId" : 21462, "type" : "INPUT", "segments" : [ { "from" : { "x" : 982, "y" : 90 }, "to" : { "x" : 999, "y" : 75 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21455, "reactomeId" : 10605464, "displayName" : "K63polyUb-STING", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1380, "y" : 111 }, "minX" : 961, "maxX" : 1444, "minY" : 76, "maxY" : 180, "prop" : { "x" : 1323, "y" : 100, "width" : 115, "height" : 23 }, "textPosition" : { "x" : 1324, "y" : 101 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1438, "y" : 100 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1438, "y" : 100 } } }, "connectors" : [ { "edgeId" : 21453, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1320, "y" : 120 }, "to" : { "x" : 977, "y" : 176 } }, { "from" : { "x" : 977, "y" : 176 }, "to" : { "x" : 961, "y" : 176 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 968, "y" : 172 }, "b" : { "x" : 961, "y" : 176 }, "c" : { "x" : 968, "y" : 180 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 968, "y" : 180 } } }, { "edgeId" : 21465, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1361, "y" : 97 }, "to" : { "x" : 1324, "y" : 76 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1353, "y" : 97 }, "b" : { "x" : 1361, "y" : 97 }, "c" : { "x" : 1357, "y" : 90 }, "type" : "ARROW", "centre" : { "x" : 1357, "y" : 90 } } } ] }, { "id" : 21457, "reactomeId" : 10605475, "displayName" : "phospho-ctnnb1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 258, "y" : 1091 }, "minX" : 203, "maxX" : 319, "minY" : 1074, "maxY" : 1103, "prop" : { "x" : 203, "y" : 1080, "width" : 110, "height" : 23 }, "textPosition" : { "x" : 224, "y" : 1074 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 313, "y" : 1080 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 313, "y" : 1080 } } }, "connectors" : [ { "edgeId" : 21456, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21458, "reactomeId" : 10605473, "displayName" : "phospho-ctnnb1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 845, "y" : 1503 }, "minX" : 790, "maxX" : 906, "minY" : 1486, "maxY" : 1515, "prop" : { "x" : 790, "y" : 1492, "width" : 110, "height" : 23 }, "textPosition" : { "x" : 811, "y" : 1486 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 900, "y" : 1492 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 900, "y" : 1492 } } }, "connectors" : [ { "edgeId" : 21456, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21460, "reactomeId" : 3244587, "displayName" : "c-GMP-AMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 790, "y" : 262 }, "minX" : 746, "maxX" : 926, "minY" : 246, "maxY" : 312, "prop" : { "x" : 746, "y" : 247, "width" : 88, "height" : 31 }, "textPosition" : { "x" : 752, "y" : 252 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 829, "y" : 252 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 829, "y" : 252 } } }, "connectors" : [ { "edgeId" : 21459, "type" : "INPUT", "segments" : [ { "from" : { "x" : 832, "y" : 281 }, "to" : { "x" : 926, "y" : 312 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21461, "reactomeId" : 10605846, "displayName" : "STING:cGAMP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 729, "y" : 499 }, "minX" : 685, "maxX" : 779, "minY" : 482, "maxY" : 511, "prop" : { "x" : 685, "y" : 488, "width" : 88, "height" : 23 }, "textPosition" : { "x" : 704, "y" : 476 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 773, "y" : 488 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 773, "y" : 488 } } }, "connectors" : [ { "edgeId" : 21459, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21463, "reactomeId" : 10598588, "displayName" : "trim33l", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 970, "y" : 44 }, "minX" : 918, "maxX" : 1324, "minY" : 27, "maxY" : 76, "prop" : { "x" : 918, "y" : 33, "width" : 105, "height" : 23 }, "textPosition" : { "x" : 945, "y" : 34 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1023, "y" : 33 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1023, "y" : 33 } } }, "connectors" : [ { "edgeId" : 21462, "type" : "INPUT", "segments" : [ { "from" : { "x" : 980, "y" : 62 }, "to" : { "x" : 999, "y" : 75 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21465, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1029, "y" : 35 }, "to" : { "x" : 1040, "y" : 33 } }, { "from" : { "x" : 1040, "y" : 33 }, "to" : { "x" : 1324, "y" : 33 } }, { "from" : { "x" : 1324, "y" : 33 }, "to" : { "x" : 1324, "y" : 76 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1035, "y" : 30 }, "b" : { "x" : 1029, "y" : 35 }, "c" : { "x" : 1037, "y" : 38 }, "type" : "ARROW", "centre" : { "x" : 1037, "y" : 38 } } } ] }, { "id" : 21464, "reactomeId" : 10598590, "displayName" : "STING:TRIM32/TRIM56", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1177, "y" : 106 }, "minX" : 1125, "maxX" : 1303, "minY" : 76, "maxY" : 125, "prop" : { "x" : 1125, "y" : 88, "width" : 105, "height" : 37 }, "textPosition" : { "x" : 1127, "y" : 90 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1230, "y" : 88 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1230, "y" : 88 } } }, "connectors" : [ { "edgeId" : 21462, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21465, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1233, "y" : 89 }, "to" : { "x" : 1275, "y" : 76 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21465, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1233, "y" : 104 }, "to" : { "x" : 1300, "y" : 102 } }, { "from" : { "x" : 1300, "y" : 102 }, "to" : { "x" : 1300, "y" : 93 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1299, "y" : 89 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1299, "y" : 89 } } } ] }, { "id" : 21466, "reactomeId" : 10560375, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1207, "y" : 55 }, "minX" : 1195, "maxX" : 1275, "minY" : 44, "maxY" : 76, "prop" : { "x" : 1195, "y" : 44, "width" : 25, "height" : 23 }, "textPosition" : { "x" : 1195, "y" : 45 }, "connectors" : [ { "edgeId" : 21465, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1226, "y" : 58 }, "to" : { "x" : 1275, "y" : 76 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1244, "y" : 61 }, "b" : { "x" : 1256, "y" : 73 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1250, "y" : 67 } } } } ] }, { "id" : 21468, "reactomeId" : 10603785, "displayName" : "STING:STING", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1100, "y" : 458 }, "minX" : 1059, "maxX" : 1172, "minY" : 426, "maxY" : 470, "prop" : { "x" : 1059, "y" : 447, "width" : 83, "height" : 23 }, "textPosition" : { "x" : 1076, "y" : 435 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1142, "y" : 447 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1142, "y" : 447 } } }, "connectors" : [ { "edgeId" : 21467, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1125, "y" : 444 }, "to" : { "x" : 1172, "y" : 426 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21469, "reactomeId" : 10581726, "displayName" : "Homologues of STAT6", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1147, "y" : 383 }, "minX" : 1124, "maxX" : 1172, "minY" : 372, "maxY" : 426, "prop" : { "x" : 1124, "y" : 372, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 1122, "y" : 352 }, "connectors" : [ { "edgeId" : 21467, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1153, "y" : 398 }, "to" : { "x" : 1172, "y" : 426 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1156, "y" : 406 }, "b" : { "x" : 1168, "y" : 418 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1162, "y" : 412 } } } } ] }, { "id" : 21470, "reactomeId" : 10606209, "displayName" : "TBK1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1092, "y" : 407 }, "minX" : 1072, "maxX" : 1172, "minY" : 390, "maxY" : 426, "prop" : { "x" : 1072, "y" : 396, "width" : 40, "height" : 23 }, "textPosition" : { "x" : 1073, "y" : 397 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1112, "y" : 396 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1112, "y" : 396 } } }, "connectors" : [ { "edgeId" : 21467, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1115, "y" : 411 }, "to" : { "x" : 1172, "y" : 426 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1137, "y" : 412 }, "b" : { "x" : 1149, "y" : 424 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1143, "y" : 418 } } } } ] }, { "id" : 21471, "reactomeId" : 10606211, "displayName" : "STING:TBK1:STAT6", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1280, "y" : 461 }, "minX" : 1220, "maxX" : 1347, "minY" : 444, "maxY" : 487, "prop" : { "x" : 1220, "y" : 450, "width" : 121, "height" : 23 }, "textPosition" : { "x" : 1220, "y" : 452 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1341, "y" : 450 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1341, "y" : 450 } } }, "connectors" : [ { "edgeId" : 21472, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1309, "y" : 476 }, "to" : { "x" : 1346, "y" : 487 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21467, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21473, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1397, "y" : 487 }, "minX" : 1346, "maxX" : 1418, "minY" : 471, "maxY" : 503, "prop" : { "x" : 1377, "y" : 472, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1381, "y" : 477 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1412, "y" : 477 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1412, "y" : 477 } } }, "connectors" : [ { "edgeId" : 21472, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1374, "y" : 487 }, "to" : { "x" : 1346, "y" : 487 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1354, "y" : 481 }, "b" : { "x" : 1366, "y" : 493 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1360, "y" : 487 } } } } ] }, { "id" : 21474, "reactomeId" : 10606192, "displayName" : "STING:p-S172-TBK1:STAT6", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1351, "y" : 566 }, "minX" : 1301, "maxX" : 1407, "minY" : 525, "maxY" : 636, "prop" : { "x" : 1301, "y" : 548, "width" : 100, "height" : 37 }, "textPosition" : { "x" : 1303, "y" : 550 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1401, "y" : 548 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1401, "y" : 548 } } }, "connectors" : [ { "edgeId" : 21472, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1349, "y" : 545 }, "to" : { "x" : 1347, "y" : 525 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1344, "y" : 539 }, "b" : { "x" : 1349, "y" : 545 }, "c" : { "x" : 1352, "y" : 538 }, "type" : "ARROW", "centre" : { "x" : 1352, "y" : 538 } } }, { "edgeId" : 21476, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1352, "y" : 588 }, "to" : { "x" : 1354, "y" : 614 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21476, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1343, "y" : 588 }, "to" : { "x" : 1330, "y" : 620 } }, { "from" : { "x" : 1330, "y" : 620 }, "to" : { "x" : 1342, "y" : 629 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1345, "y" : 632 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1345, "y" : 632 } } } ] }, { "id" : 21538, "reactomeId" : 10649308, "displayName" : "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 111, "y" : 1555 }, "minX" : 45, "maxX" : 177, "minY" : 1519, "maxY" : 1592, "prop" : { "x" : 45, "y" : 1519, "width" : 132, "height" : 73 }, "textPosition" : { "x" : 63, "y" : 1513 }, "connectors" : [ ] }, { "id" : 21475, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1401, "y" : 525 }, "minX" : 1347, "maxX" : 1423, "minY" : 509, "maxY" : 541, "prop" : { "x" : 1381, "y" : 510, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1385, "y" : 515 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1417, "y" : 515 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1417, "y" : 515 } } }, "connectors" : [ { "edgeId" : 21472, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1378, "y" : 525 }, "to" : { "x" : 1347, "y" : 525 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1356, "y" : 519 }, "b" : { "x" : 1368, "y" : 531 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1362, "y" : 525 } } }, "endShape" : { "a" : { "x" : 1371, "y" : 529 }, "b" : { "x" : 1378, "y" : 525 }, "c" : { "x" : 1371, "y" : 521 }, "type" : "ARROW", "centre" : { "x" : 1371, "y" : 521 } } } ] }, { "id" : 21477, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1411, "y" : 616 }, "minX" : 1354, "maxX" : 1432, "minY" : 600, "maxY" : 632, "prop" : { "x" : 1391, "y" : 601, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1395, "y" : 606 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1426, "y" : 606 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1426, "y" : 606 } } }, "connectors" : [ { "edgeId" : 21476, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1388, "y" : 615 }, "to" : { "x" : 1354, "y" : 614 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1365, "y" : 608 }, "b" : { "x" : 1377, "y" : 620 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1371, "y" : 614 } } } } ] }, { "id" : 21478, "reactomeId" : 10606194, "displayName" : "STING:p-S172-TBK1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 946, "y" : 601 }, "minX" : 881, "maxX" : 1356, "minY" : 556, "maxY" : 686, "prop" : { "x" : 881, "y" : 590, "width" : 131, "height" : 23 }, "textPosition" : { "x" : 883, "y" : 592 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1012, "y" : 590 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1012, "y" : 590 } } }, "connectors" : [ { "edgeId" : 21476, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 947, "y" : 587 }, "to" : { "x" : 950, "y" : 557 } }, { "from" : { "x" : 950, "y" : 557 }, "to" : { "x" : 1275, "y" : 556 } }, { "from" : { "x" : 1275, "y" : 556 }, "to" : { "x" : 1326, "y" : 686 } }, { "from" : { "x" : 1326, "y" : 686 }, "to" : { "x" : 1356, "y" : 655 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 944, "y" : 580 }, "b" : { "x" : 947, "y" : 587 }, "c" : { "x" : 952, "y" : 581 }, "type" : "ARROW", "centre" : { "x" : 952, "y" : 581 } } } ] }, { "id" : 21479, "reactomeId" : 10606202, "displayName" : "Homologues of p-S407-STAT6", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1361, "y" : 720 }, "minX" : 1312, "maxX" : 1411, "minY" : 655, "maxY" : 750, "prop" : { "x" : 1312, "y" : 709, "width" : 99, "height" : 23 }, "textPosition" : { "x" : 1316, "y" : 696 }, "connectors" : [ { "edgeId" : 21476, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1360, "y" : 706 }, "to" : { "x" : 1356, "y" : 655 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1352, "y" : 674 }, "b" : { "x" : 1364, "y" : 686 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1358, "y" : 680 } } }, "endShape" : { "a" : { "x" : 1355, "y" : 699 }, "b" : { "x" : 1360, "y" : 706 }, "c" : { "x" : 1363, "y" : 699 }, "type" : "ARROW", "centre" : { "x" : 1363, "y" : 699 } } }, { "edgeId" : 21481, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1361, "y" : 735 }, "to" : { "x" : 1362, "y" : 750 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21480, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1417, "y" : 662 }, "minX" : 1356, "maxX" : 1439, "minY" : 646, "maxY" : 678, "prop" : { "x" : 1397, "y" : 647, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1401, "y" : 652 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1433, "y" : 652 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1433, "y" : 652 } } }, "connectors" : [ { "edgeId" : 21476, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1394, "y" : 659 }, "to" : { "x" : 1356, "y" : 655 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1369, "y" : 651 }, "b" : { "x" : 1381, "y" : 663 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1375, "y" : 657 } } }, "endShape" : { "a" : { "x" : 1387, "y" : 662 }, "b" : { "x" : 1394, "y" : 659 }, "c" : { "x" : 1388, "y" : 654 }, "type" : "ARROW", "centre" : { "x" : 1388, "y" : 654 } } } ] }, { "id" : 21482, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1409, "y" : 754 }, "minX" : 1362, "maxX" : 1430, "minY" : 738, "maxY" : 770, "prop" : { "x" : 1389, "y" : 739, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1393, "y" : 744 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1424, "y" : 744 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1424, "y" : 744 } } }, "connectors" : [ { "edgeId" : 21481, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1386, "y" : 752 }, "to" : { "x" : 1362, "y" : 750 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21483, "reactomeId" : 10606176, "displayName" : "Homologues of p-S407,Y641-STAT6", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1365, "y" : 861 }, "minX" : 1317, "maxX" : 1413, "minY" : 799, "maxY" : 960, "prop" : { "x" : 1317, "y" : 843, "width" : 96, "height" : 37 }, "textPosition" : { "x" : 1320, "y" : 837 }, "connectors" : [ { "edgeId" : 21481, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1364, "y" : 840 }, "to" : { "x" : 1363, "y" : 799 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1360, "y" : 833 }, "b" : { "x" : 1364, "y" : 840 }, "c" : { "x" : 1368, "y" : 833 }, "type" : "ARROW", "centre" : { "x" : 1368, "y" : 833 } } }, { "edgeId" : 21485, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1359, "y" : 948 }, "b" : { "x" : 1371, "y" : 960 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1365, "y" : 954 } } } } ] }, { "id" : 21547, "reactomeId" : 10648312, "displayName" : "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 510, "y" : 637 }, "minX" : 414, "maxX" : 607, "minY" : 595, "maxY" : 679, "prop" : { "x" : 414, "y" : 595, "width" : 193, "height" : 84 }, "textPosition" : { "x" : 415, "y" : 601 }, "connectors" : [ ] }, { "id" : 21484, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1409, "y" : 804 }, "minX" : 1363, "maxX" : 1431, "minY" : 788, "maxY" : 820, "prop" : { "x" : 1389, "y" : 789, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1393, "y" : 794 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1425, "y" : 794 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1425, "y" : 794 } } }, "connectors" : [ { "edgeId" : 21481, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1386, "y" : 801 }, "to" : { "x" : 1363, "y" : 799 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1379, "y" : 804 }, "b" : { "x" : 1386, "y" : 801 }, "c" : { "x" : 1379, "y" : 796 }, "type" : "ARROW", "centre" : { "x" : 1379, "y" : 796 } } } ] }, { "id" : 21486, "reactomeId" : 10606178, "displayName" : "p-S407,Y641-STAT6 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1314, "y" : 1158 }, "minX" : 1266, "maxX" : 1368, "minY" : 1134, "maxY" : 1177, "prop" : { "x" : 1266, "y" : 1140, "width" : 96, "height" : 37 }, "textPosition" : { "x" : 1268, "y" : 1142 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1362, "y" : 1140 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1362, "y" : 1140 } } }, "connectors" : [ { "edgeId" : 21485, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 21487, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21488, "reactomeId" : 10606188, "displayName" : "p-S407,Y641-STAT6 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1271, "y" : 1418 }, "minX" : 1223, "maxX" : 1325, "minY" : 1394, "maxY" : 1437, "prop" : { "x" : 1223, "y" : 1400, "width" : 96, "height" : 37 }, "textPosition" : { "x" : 1225, "y" : 1402 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1319, "y" : 1400 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1319, "y" : 1400 } } }, "connectors" : [ { "edgeId" : 21487, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21490, "reactomeId" : 10605535, "displayName" : "mre11a", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 369, "y" : 535 }, "minX" : 340, "maxX" : 441, "minY" : 515, "maxY" : 547, "prop" : { "x" : 340, "y" : 524, "width" : 58, "height" : 23 }, "textPosition" : { "x" : 341, "y" : 525 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 398, "y" : 524 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 398, "y" : 524 } } }, "connectors" : [ { "edgeId" : 21489, "type" : "INPUT", "segments" : [ { "from" : { "x" : 401, "y" : 526 }, "to" : { "x" : 441, "y" : 515 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21491, "reactomeId" : 874088, "displayName" : "Double-stranded DNA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 423, "y" : 477 }, "minX" : 363, "maxX" : 485, "minY" : 454, "maxY" : 515, "prop" : { "x" : 363, "y" : 455, "width" : 121, "height" : 45 }, "textPosition" : { "x" : 365, "y" : 460 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 479, "y" : 460 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 479, "y" : 460 } } }, "connectors" : [ { "edgeId" : 21489, "type" : "INPUT", "segments" : [ { "from" : { "x" : 433, "y" : 503 }, "to" : { "x" : 441, "y" : 515 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21492, "reactomeId" : 10605537, "displayName" : "MRE11:dsDNA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 559, "y" : 517 }, "minX" : 512, "maxX" : 612, "minY" : 500, "maxY" : 529, "prop" : { "x" : 512, "y" : 506, "width" : 94, "height" : 23 }, "textPosition" : { "x" : 532, "y" : 494 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 606, "y" : 506 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 606, "y" : 506 } } }, "connectors" : [ { "edgeId" : 21489, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21494, "reactomeId" : 10570862, "displayName" : "p-2S-IRF7:p-2S-IRF7", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 377, "y" : 1565 }, "minX" : 322, "maxX" : 438, "minY" : 1541, "maxY" : 1584, "prop" : { "x" : 322, "y" : 1547, "width" : 110, "height" : 37 }, "textPosition" : { "x" : 326, "y" : 1549 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 432, "y" : 1547 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 432, "y" : 1547 } } }, "connectors" : [ { "edgeId" : 21493, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 21495, "reactomeId" : 10572232, "displayName" : "2xp-S477,S479-IRF7", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 609, "y" : 1567 }, "minX" : 554, "maxX" : 670, "minY" : 1543, "maxY" : 1586, "prop" : { "x" : 554, "y" : 1549, "width" : 110, "height" : 37 }, "textPosition" : { "x" : 556, "y" : 1551 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 664, "y" : 1549 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 664, "y" : 1549 } } }, "connectors" : [ { "edgeId" : 21493, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 21472, "reactomeId" : 10606217, "displayName" : "TBK1 is phosphorylated within STING:TBK1:STAT6 complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1347, "y" : 507 }, "minX" : 1341, "maxX" : 1353, "minY" : 487, "maxY" : 525, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1346, "y" : 487 }, "to" : { "x" : 1347, "y" : 507 } }, { "from" : { "x" : 1347, "y" : 507 }, "to" : { "x" : 1347, "y" : 525 } } ], "reactionShape" : { "a" : { "x" : 1341, "y" : 501 }, "b" : { "x" : 1353, "y" : 513 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1347, "y" : 507 } }, "inputs" : [ { "id" : 21471, "points" : [ { "x" : 1309, "y" : 476 } ] }, { "id" : 21473, "points" : [ { "x" : 1374, "y" : 487 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 21474, "points" : [ { "x" : 1349, "y" : 545 } ] }, { "id" : 21475, "points" : [ { "x" : 1378, "y" : 525 } ], "stoichiometry" : 2 } ] }, { "id" : 21476, "reactomeId" : 10606205, "displayName" : "TBK1 phosphorylates STAT6 at Ser407", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1355, "y" : 639 }, "minX" : 1349, "maxX" : 1361, "minY" : 614, "maxY" : 655, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1354, "y" : 614 }, "to" : { "x" : 1355, "y" : 639 } }, { "from" : { "x" : 1355, "y" : 639 }, "to" : { "x" : 1356, "y" : 655 } } ], "reactionShape" : { "a" : { "x" : 1349, "y" : 633 }, "b" : { "x" : 1361, "y" : 645 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1355, "y" : 639 } }, "inputs" : [ { "id" : 21477, "points" : [ { "x" : 1388, "y" : 615 } ], "stoichiometry" : 2 }, { "id" : 21474, "points" : [ { "x" : 1352, "y" : 588 } ] } ], "outputs" : [ { "id" : 21478, "points" : [ { "x" : 947, "y" : 587 }, { "x" : 950, "y" : 557 }, { "x" : 1275, "y" : 556 }, { "x" : 1326, "y" : 686 } ] }, { "id" : 21479, "points" : [ { "x" : 1360, "y" : 706 } ], "stoichiometry" : 2 }, { "id" : 21480, "points" : [ { "x" : 1394, "y" : 659 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 21474, "points" : [ { "x" : 1343, "y" : 588 }, { "x" : 1330, "y" : 620 } ] } ] }, { "id" : 21481, "reactomeId" : 10606215, "displayName" : "p-S407-STAT6 is phosphorylated at Tyr641", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1362, "y" : 776 }, "minX" : 1356, "maxX" : 1368, "minY" : 750, "maxY" : 799, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1362, "y" : 750 }, "to" : { "x" : 1362, "y" : 776 } }, { "from" : { "x" : 1362, "y" : 776 }, "to" : { "x" : 1363, "y" : 799 } } ], "reactionShape" : { "a" : { "x" : 1356, "y" : 770 }, "b" : { "x" : 1368, "y" : 782 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1362, "y" : 776 } }, "inputs" : [ { "id" : 21482, "points" : [ { "x" : 1386, "y" : 752 } ] }, { "id" : 21479, "points" : [ { "x" : 1361, "y" : 735 } ] } ], "outputs" : [ { "id" : 21483, "points" : [ { "x" : 1364, "y" : 840 } ] }, { "id" : 21484, "points" : [ { "x" : 1386, "y" : 801 } ] } ] }, { "id" : 21449, "reactomeId" : 10603789, "displayName" : "STING binds c-di-GMP", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 864, "y" : 341 }, "minX" : 763, "maxX" : 870, "minY" : 319, "maxY" : 435, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 864, "y" : 319 }, "to" : { "x" : 864, "y" : 341 } }, { "from" : { "x" : 864, "y" : 341 }, "to" : { "x" : 763, "y" : 435 } } ], "endShape" : { "a" : { "x" : 765, "y" : 427 }, "b" : { "x" : 763, "y" : 435 }, "c" : { "x" : 771, "y" : 433 }, "type" : "ARROW", "centre" : { "x" : 771, "y" : 433 } }, "reactionShape" : { "a" : { "x" : 858, "y" : 335 }, "b" : { "x" : 870, "y" : 347 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 864, "y" : 341 } }, "inputs" : [ { "id" : 21450, "points" : [ { "x" : 742, "y" : 298 } ] }, { "id" : 21451, "points" : [ { "x" : 991, "y" : 243 } ] } ], "outputs" : [ { "id" : 21452 } ] }, { "id" : 21453, "reactomeId" : 10605466, "displayName" : "STING dimerization", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 952, "y" : 176 }, "minX" : 946, "maxX" : 997, "minY" : 119, "maxY" : 214, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 967, "y" : 119 }, "to" : { "x" : 952, "y" : 176 } }, { "from" : { "x" : 952, "y" : 176 }, "to" : { "x" : 997, "y" : 214 } } ], "endShape" : { "a" : { "x" : 989, "y" : 213 }, "b" : { "x" : 997, "y" : 214 }, "c" : { "x" : 994, "y" : 206 }, "type" : "ARROW", "centre" : { "x" : 994, "y" : 206 } }, "reactionShape" : { "c" : { "x" : 952, "y" : 176 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 952, "y" : 176 } }, "inputs" : [ { "id" : 21454, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 21451 } ], "activators" : [ { "id" : 21455, "points" : [ { "x" : 1320, "y" : 120 }, { "x" : 977, "y" : 176 } ] } ] }, { "id" : 21485, "reactomeId" : 10606207, "displayName" : "p-S407,Y641-STAT6 is dimerized", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1365, "y" : 1026 }, "minX" : 1321, "maxX" : 1371, "minY" : 883, "maxY" : 1137, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1365, "y" : 883 }, "to" : { "x" : 1365, "y" : 1026 } }, { "from" : { "x" : 1365, "y" : 1026 }, "to" : { "x" : 1321, "y" : 1137 } } ], "endShape" : { "a" : { "x" : 1320, "y" : 1129 }, "b" : { "x" : 1321, "y" : 1137 }, "c" : { "x" : 1327, "y" : 1132 }, "type" : "ARROW", "centre" : { "x" : 1327, "y" : 1132 } }, "reactionShape" : { "c" : { "x" : 1365, "y" : 1026 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1365, "y" : 1026 } }, "inputs" : [ { "id" : 21483, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 21486 } ] }, { "id" : 21487, "reactomeId" : 10606190, "displayName" : "p-S407,Y641-STAT6 dimer migrates to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1317, "y" : 1362 }, "minX" : 1286, "maxX" : 1323, "minY" : 1180, "maxY" : 1397, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1314, "y" : 1180 }, "to" : { "x" : 1317, "y" : 1362 } }, { "from" : { "x" : 1317, "y" : 1362 }, "to" : { "x" : 1286, "y" : 1397 } } ], "endShape" : { "a" : { "x" : 1288, "y" : 1389 }, "b" : { "x" : 1286, "y" : 1397 }, "c" : { "x" : 1294, "y" : 1394 }, "type" : "ARROW", "centre" : { "x" : 1294, "y" : 1394 } }, "reactionShape" : { "a" : { "x" : 1311, "y" : 1356 }, "b" : { "x" : 1323, "y" : 1368 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1317, "y" : 1362 } }, "inputs" : [ { "id" : 21486 } ], "outputs" : [ { "id" : 21488 } ] }, { "id" : 21456, "reactomeId" : 10605477, "displayName" : "Beta-catenin migrates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 487, "y" : 1366 }, "minX" : 267, "maxX" : 814, "minY" : 1106, "maxY" : 1489, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 267, "y" : 1106 }, "to" : { "x" : 487, "y" : 1366 } }, { "from" : { "x" : 487, "y" : 1366 }, "to" : { "x" : 814, "y" : 1489 } } ], "endShape" : { "a" : { "x" : 806, "y" : 1490 }, "b" : { "x" : 814, "y" : 1489 }, "c" : { "x" : 809, "y" : 1483 }, "type" : "ARROW", "centre" : { "x" : 809, "y" : 1483 } }, "reactionShape" : { "a" : { "x" : 481, "y" : 1360 }, "b" : { "x" : 493, "y" : 1372 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 487, "y" : 1366 } }, "inputs" : [ { "id" : 21457 } ], "outputs" : [ { "id" : 21458 } ] }, { "id" : 21489, "reactomeId" : 10605539, "displayName" : "MRE11 binds cytosolic DNA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 468, "y" : 516 }, "minX" : 441, "maxX" : 509, "minY" : 510, "maxY" : 522, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 441, "y" : 515 }, "to" : { "x" : 468, "y" : 516 } }, { "from" : { "x" : 468, "y" : 516 }, "to" : { "x" : 509, "y" : 516 } } ], "endShape" : { "a" : { "x" : 502, "y" : 520 }, "b" : { "x" : 509, "y" : 516 }, "c" : { "x" : 502, "y" : 512 }, "type" : "ARROW", "centre" : { "x" : 502, "y" : 512 } }, "reactionShape" : { "c" : { "x" : 468, "y" : 516 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 468, "y" : 516 } }, "inputs" : [ { "id" : 21490, "points" : [ { "x" : 401, "y" : 526 } ] }, { "id" : 21491, "points" : [ { "x" : 433, "y" : 503 } ] } ], "outputs" : [ { "id" : 21492 } ] }, { "id" : 21459, "reactomeId" : 10605848, "displayName" : "STING binds cyclic GMP-AMP", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 927, "y" : 347 }, "minX" : 763, "maxX" : 933, "minY" : 312, "maxY" : 485, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 926, "y" : 312 }, "to" : { "x" : 927, "y" : 347 } }, { "from" : { "x" : 927, "y" : 347 }, "to" : { "x" : 797, "y" : 476 } }, { "from" : { "x" : 797, "y" : 476 }, "to" : { "x" : 763, "y" : 485 } } ], "endShape" : { "a" : { "x" : 769, "y" : 479 }, "b" : { "x" : 763, "y" : 485 }, "c" : { "x" : 771, "y" : 487 }, "type" : "ARROW", "centre" : { "x" : 771, "y" : 487 } }, "reactionShape" : { "a" : { "x" : 921, "y" : 341 }, "b" : { "x" : 933, "y" : 353 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 927, "y" : 347 } }, "inputs" : [ { "id" : 21460, "points" : [ { "x" : 832, "y" : 281 } ] }, { "id" : 21451, "points" : [ { "x" : 998, "y" : 243 } ] } ], "outputs" : [ { "id" : 21461 } ] }, { "id" : 21493, "reactomeId" : 10638724, "displayName" : "p-IRF7:p-IRF7 translocates to the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 491, "y" : 1567 }, "minX" : 435, "maxX" : 551, "minY" : 1561, "maxY" : 1573, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 435, "y" : 1565 }, "to" : { "x" : 491, "y" : 1567 } }, { "from" : { "x" : 491, "y" : 1567 }, "to" : { "x" : 551, "y" : 1567 } } ], "endShape" : { "a" : { "x" : 544, "y" : 1571 }, "b" : { "x" : 551, "y" : 1567 }, "c" : { "x" : 544, "y" : 1563 }, "type" : "ARROW", "centre" : { "x" : 544, "y" : 1563 } }, "reactionShape" : { "a" : { "x" : 485, "y" : 1561 }, "b" : { "x" : 497, "y" : 1573 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 491, "y" : 1567 } }, "inputs" : [ { "id" : 21494 } ], "outputs" : [ { "id" : 21495 } ] }, { "id" : 21462, "reactomeId" : 10598592, "displayName" : "STING binds TRIM32 or TRIM56", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1055, "y" : 74 }, "minX" : 999, "maxX" : 1122, "minY" : 68, "maxY" : 92, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 999, "y" : 75 }, "to" : { "x" : 1055, "y" : 74 } }, { "from" : { "x" : 1055, "y" : 74 }, "to" : { "x" : 1122, "y" : 92 } } ], "endShape" : { "a" : { "x" : 1114, "y" : 94 }, "b" : { "x" : 1122, "y" : 92 }, "c" : { "x" : 1116, "y" : 86 }, "type" : "ARROW", "centre" : { "x" : 1116, "y" : 86 } }, "reactionShape" : { "c" : { "x" : 1055, "y" : 74 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1055, "y" : 74 } }, "inputs" : [ { "id" : 21454, "points" : [ { "x" : 982, "y" : 90 } ] }, { "id" : 21463, "points" : [ { "x" : 980, "y" : 62 } ] } ], "outputs" : [ { "id" : 21464 } ] }, { "id" : 21465, "reactomeId" : 10605470, "displayName" : "STING ubiquitination by TRIM32 or TRIM56", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1299, "y" : 77 }, "minX" : 1275, "maxX" : 1324, "minY" : 71, "maxY" : 83, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1275, "y" : 76 }, "to" : { "x" : 1299, "y" : 77 } }, { "from" : { "x" : 1299, "y" : 77 }, "to" : { "x" : 1324, "y" : 76 } } ], "reactionShape" : { "a" : { "x" : 1293, "y" : 71 }, "b" : { "x" : 1305, "y" : 83 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1299, "y" : 77 } }, "inputs" : [ { "id" : 21466, "points" : [ { "x" : 1226, "y" : 58 } ], "stoichiometry" : 3 }, { "id" : 21464, "points" : [ { "x" : 1233, "y" : 89 } ] } ], "outputs" : [ { "id" : 21455, "points" : [ { "x" : 1361, "y" : 97 } ] }, { "id" : 21463, "points" : [ { "x" : 1029, "y" : 35 }, { "x" : 1040, "y" : 33 }, { "x" : 1324, "y" : 33 } ] } ], "catalysts" : [ { "id" : 21464, "points" : [ { "x" : 1233, "y" : 104 }, { "x" : 1300, "y" : 102 } ] } ] }, { "id" : 21467, "reactomeId" : 10606213, "displayName" : "STING recruits TBK1 and STAT6", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1196, "y" : 425 }, "minX" : 1172, "maxX" : 1253, "minY" : 419, "maxY" : 447, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1172, "y" : 426 }, "to" : { "x" : 1196, "y" : 425 } }, { "from" : { "x" : 1196, "y" : 425 }, "to" : { "x" : 1253, "y" : 447 } } ], "endShape" : { "a" : { "x" : 1245, "y" : 448 }, "b" : { "x" : 1253, "y" : 447 }, "c" : { "x" : 1248, "y" : 441 }, "type" : "ARROW", "centre" : { "x" : 1248, "y" : 441 } }, "reactionShape" : { "c" : { "x" : 1196, "y" : 425 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1196, "y" : 425 } }, "inputs" : [ { "id" : 21468, "points" : [ { "x" : 1125, "y" : 444 } ] }, { "id" : 21469, "points" : [ { "x" : 1153, "y" : 398 } ], "stoichiometry" : 2 }, { "id" : 21470, "points" : [ { "x" : 1115, "y" : 411 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 21471 } ] } ], "compartments" : [ { "id" : 21526, "reactomeId" : 70260, "displayName" : "endoplasmic reticulum", "schemaClass" : "GO_CellularComponent", "renderableClass" : "Compartment", "position" : { "x" : 1187, "y" : 160 }, "minX" : 970, "maxX" : 1404, "minY" : 95, "maxY" : 226, "prop" : { "x" : 970, "y" : 95, "width" : 434, "height" : 131 }, "textPosition" : { "x" : 1138, "y" : 179 }, "insets" : { "x" : 980, "y" : 105, "width" : 414, "height" : 111 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 21451, 21454, 21464, 21455 ] }, { "id" : 21510, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 944, "y" : 1493 }, "minX" : 507, "maxX" : 1381, "minY" : 1384, "maxY" : 1603, "prop" : { "x" : 507, "y" : 1384, "width" : 874, "height" : 219 }, "textPosition" : { "x" : 832, "y" : 1558 }, "insets" : { "x" : 517, "y" : 1394, "width" : 854, "height" : 199 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 21458, 21495, 21488 ] }, { "id" : 21544, "reactomeId" : 17940, "displayName" : "endosome", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 643, "y" : 1323 }, "minX" : 558, "maxX" : 728, "minY" : 1293, "maxY" : 1354, "prop" : { "x" : 558, "y" : 1293, "width" : 170, "height" : 61 }, "textPosition" : { "x" : 578, "y" : 1311 }, "insets" : { "x" : 568, "y" : 1303, "width" : 150, "height" : 41 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 21496, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 775, "y" : 809 }, "minX" : 0, "maxX" : 1550, "minY" : 0, "maxY" : 1618, "prop" : { "x" : 0, "y" : 0, "width" : 1550, "height" : 1618 }, "textPosition" : { "x" : 177, "y" : 1308 }, "insets" : { "x" : 10, "y" : 10, "width" : 1530, "height" : 1598 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 21510, 21449, 21457, 21548, 21549, 21550, 21494, 21551, 21459, 21492, 21526, 21450, 21460, 21461, 21461, 21452, 21461, 21452, 21461, 21452, 21461, 21452, 21462, 21463, 21466, 21452, 21470, 21469, 21528, 21467, 21452, 21461, 21473, 21472, 21475, 21476, 21477, 21479, 21480, 21483, 21484, 21482, 21481, 21485, 21486, 21465, 21489, 21490, 21538, 21552, 21491, 21487, 21456, 21544, 21493, 21453, 21547, 21553 ] }, { "id" : 21528, "reactomeId" : 437050, "displayName" : "cytoplasmic vesicle lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1037, "y" : 531 }, "minX" : 729, "maxX" : 1345, "minY" : 451, "maxY" : 611, "prop" : { "x" : 729, "y" : 451, "width" : 616, "height" : 160 }, "textPosition" : { "x" : 928, "y" : 497 }, "insets" : { "x" : 739, "y" : 461, "width" : 596, "height" : 140 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 21478, 21531, 21471, 21468, 21461, 21452, 21474, 21461, 21452 ] } ], "notes" : [ { "id" : 21531, "displayName" : "(perinuclear vesicle)", "renderableClass" : "Note", "position" : { "x" : 1085, "y" : 533 }, "minX" : 1001, "maxX" : 1169, "minY" : 524, "maxY" : 542, "prop" : { "x" : 1001, "y" : 524, "width" : 168, "height" : 18 }, "textPosition" : { "x" : 1017, "y" : 523 } } ], "links" : [ ], "shadows" : [ { "id" : 21548, "reactomeId" : 10649608, "displayName" : "Regulation of innate immune responses to cytosolic DNA", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1178, "y" : 79 }, "minX" : 908, "maxX" : 1448, "minY" : 23, "maxY" : 135, "prop" : { "x" : 908, "y" : 23, "width" : 540, "height" : 60 }, "points" : [ { "x" : 908, "y" : 23 }, { "x" : 1448, "y" : 23 }, { "x" : 1448, "y" : 135 }, { "x" : 908, "y" : 135 } ], "colour" : "#4684ee" }, { "id" : 21549, "reactomeId" : 10649700, "displayName" : "STING mediated induction of host immune responses", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1051, "y" : 765 }, "minX" : 655, "maxX" : 1448, "minY" : 83, "maxY" : 1447, "prop" : { "x" : 655, "y" : 135, "width" : 793, "height" : 935 }, "points" : [ { "x" : 655, "y" : 83 }, { "x" : 1448, "y" : 83 }, { "x" : 1448, "y" : 1447 }, { "x" : 655, "y" : 1447 } ], "colour" : "#dc3912" }, { "id" : 21550, "reactomeId" : 10649768, "displayName" : "LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 551, "y" : 1297 }, "minX" : 193, "maxX" : 910, "minY" : 1070, "maxY" : 1525, "prop" : { "x" : 193, "y" : 1070, "width" : 462, "height" : 377 }, "points" : [ { "x" : 193, "y" : 1070 }, { "x" : 910, "y" : 1070 }, { "x" : 910, "y" : 1525 }, { "x" : 193, "y" : 1525 } ], "colour" : "#008000" }, { "id" : 21551, "reactomeId" : 10650508, "displayName" : "DEx/H-box helicases activate type I IFN and inflammatory cytokines production ", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 493, "y" : 1566 }, "minX" : 312, "maxX" : 674, "minY" : 1537, "maxY" : 1596, "prop" : { "x" : 312, "y" : 1537, "width" : 362, "height" : 59 }, "points" : [ { "x" : 312, "y" : 1537 }, { "x" : 674, "y" : 1537 }, { "x" : 674, "y" : 1596 }, { "x" : 312, "y" : 1596 } ], "colour" : "#666666" } ], "minX" : 0, "maxX" : 1550, "minY" : 0, "maxY" : 1618, "disease" : false }