{
  "dbId" : 10648518,
  "stId" : "R-DRE-157858",
  "speciesName" : "Danio rerio",
  "nodes" : [ {
    "dbId" : 10573088,
    "stId" : "R-DRE-190647",
    "displayName" : "Connexin 32 connexon [endoplasmic reticulum membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 22731 ],
    "parents" : [ ],
    "children" : [ 10573086 ]
  }, {
    "dbId" : 10572195,
    "stId" : "R-DRE-167585-2",
    "displayName" : "AP2M1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q7ZW98",
    "standardIdentifier" : "uniprot:Q7ZW98",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10572197 ],
    "children" : [ ]
  }, {
    "dbId" : 10573093,
    "stId" : "R-DRE-190649",
    "displayName" : "gja1 [Golgi membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "O57474",
    "standardIdentifier" : "uniprot:O57474",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "gja1" ],
    "parents" : [ 10573095 ],
    "children" : [ ]
  }, {
    "dbId" : 10572197,
    "stId" : "R-DRE-167585-3",
    "displayName" : "Homologues of AP2M1 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "parents" : [ 10574153 ],
    "children" : [ 10572191, 10572195 ]
  }, {
    "dbId" : 10573095,
    "stId" : "R-DRE-190652",
    "displayName" : "Connexin 43 connexon [Golgi membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 22733 ],
    "parents" : [ ],
    "children" : [ 10573093 ]
  }, {
    "dbId" : 10574119,
    "stId" : "R-DRE-196032",
    "displayName" : "Ghost homologue of Clathrin heavy chain [plasma membrane]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 68323,
    "parents" : [ 10574127 ],
    "children" : [ ]
  }, {
    "dbId" : 10574123,
    "stId" : "R-DRE-2980617",
    "displayName" : "cltb [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "A0A286Y9F1",
    "standardIdentifier" : "uniprot:A0A286Y9F1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "cltb" ],
    "parents" : [ 10574125 ],
    "children" : [ ]
  }, {
    "dbId" : 10574125,
    "stId" : "R-DRE-2980669",
    "displayName" : "Clathrin light chains [plasma membrane]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 68323,
    "parents" : [ 10574127 ],
    "children" : [ 10574123, 10572209 ]
  }, {
    "dbId" : 10574127,
    "stId" : "R-DRE-196043",
    "displayName" : "Clathrin [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "parents" : [ 10574153 ],
    "children" : [ 10574125, 10574119 ]
  }, {
    "dbId" : 10573102,
    "stId" : "R-DRE-190654",
    "displayName" : "gja1 [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 22745 ],
    "identifier" : "O57474",
    "standardIdentifier" : "uniprot:O57474",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "gja1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10572209,
    "stId" : "R-DRE-2980611",
    "displayName" : "clta [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6P937",
    "standardIdentifier" : "uniprot:Q6P937",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "clta" ],
    "parents" : [ 10574125 ],
    "children" : [ ]
  }, {
    "dbId" : 10574131,
    "stId" : "R-DRE-196016",
    "displayName" : "actbb [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q7ZVF9",
    "standardIdentifier" : "uniprot:Q7ZVF9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "actbb" ],
    "parents" : [ 10574137 ],
    "children" : [ ]
  }, {
    "dbId" : 10574135,
    "stId" : "R-DRE-196016-2",
    "displayName" : "actba [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q7ZVI7",
    "standardIdentifier" : "uniprot:Q7ZVI7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "actba" ],
    "parents" : [ 10574137 ],
    "children" : [ ]
  }, {
    "dbId" : 10574137,
    "stId" : "R-DRE-196016-3",
    "displayName" : "Homologues of ACTB [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 68323,
    "parents" : [ 10574139 ],
    "children" : [ 10574135, 10574131 ]
  }, {
    "dbId" : 10574139,
    "stId" : "R-DRE-196045",
    "displayName" : "ACTB, ACTG1 [plasma membrane]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 68323,
    "parents" : [ 10574141 ],
    "children" : [ 10574137 ]
  }, {
    "dbId" : 10574141,
    "stId" : "R-DRE-196015",
    "displayName" : "F-actin [plasma membrane]",
    "schemaClass" : "Polymer",
    "speciesId" : 68323,
    "parents" : [ 10574153 ],
    "children" : [ 10574139 ]
  }, {
    "dbId" : 10572348,
    "stId" : "R-DRE-65043",
    "displayName" : "SRC-1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q1JPZ3",
    "standardIdentifier" : "uniprot:Q1JPZ3",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10573186 ],
    "children" : [ ]
  }, {
    "dbId" : 10574143,
    "stId" : "R-DRE-158058",
    "displayName" : "gja1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "O57474",
    "standardIdentifier" : "uniprot:O57474",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "gja1" ],
    "parents" : [ 10574145 ],
    "children" : [ ]
  }, {
    "dbId" : 10574145,
    "stId" : "R-DRE-158053",
    "displayName" : "Connexin 43  hemi-channel [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 22747 ],
    "parents" : [ 10574147 ],
    "children" : [ 10574143 ]
  }, {
    "dbId" : 10573184,
    "stId" : "R-DRE-191657",
    "displayName" : "phospho-gja1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "O57474",
    "standardIdentifier" : "uniprot:O57474",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "gja1" ],
    "parents" : [ 10573186 ],
    "children" : [ ]
  }, {
    "dbId" : 10574147,
    "stId" : "R-DRE-191070",
    "displayName" : "Hemi-channels [plasma membrane]",
    "schemaClass" : "CandidateSet",
    "speciesId" : 68323,
    "diagramIds" : [ 22749 ],
    "parents" : [ 10574149 ],
    "children" : [ 10574145 ]
  }, {
    "dbId" : 10573186,
    "stId" : "R-DRE-191649",
    "displayName" : "c-src associated cx43 hemi-channel [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "parents" : [ 10573188 ],
    "children" : [ 10572348, 10573184 ]
  }, {
    "dbId" : 10574149,
    "stId" : "R-DRE-191068",
    "displayName" : "Junctional channel [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "parents" : [ 10574151 ],
    "children" : [ 10574147 ]
  }, {
    "dbId" : 10573188,
    "stId" : "R-DRE-191635",
    "displayName" : "c-src-associated Cx43 junctional channel [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 22743 ],
    "parents" : [ ],
    "children" : [ 10573186 ]
  }, {
    "dbId" : 10574151,
    "stId" : "R-DRE-191660",
    "displayName" : "gap junction plaque [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "parents" : [ 10574153 ],
    "children" : [ 10574149 ]
  }, {
    "dbId" : 10587526,
    "stId" : "R-DRE-190614",
    "displayName" : "gjb8 [endoplasmic reticulum-Golgi intermediate compartment]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q503F4",
    "standardIdentifier" : "uniprot:Q503F4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "gjb8" ],
    "parents" : [ 10587528 ],
    "children" : [ ]
  }, {
    "dbId" : 10574153,
    "stId" : "R-DRE-196020",
    "displayName" : "planar gap junction plaques [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 22736 ],
    "parents" : [ 10574159 ],
    "children" : [ 10574127, 10574141, 10574151, 10572197 ]
  }, {
    "dbId" : 10587528,
    "stId" : "R-DRE-190641",
    "displayName" : "Connexin 26 Connexon [endoplasmic reticulum-Golgi intermediate compartment]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 22740 ],
    "parents" : [ ],
    "children" : [ 10587526 ]
  }, {
    "dbId" : 10587530,
    "stId" : "R-DRE-53211",
    "displayName" : "gjb8 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q503F4",
    "standardIdentifier" : "uniprot:Q503F4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "gjb8" ],
    "parents" : [ 10587532 ],
    "children" : [ ]
  }, {
    "dbId" : 10574157,
    "stId" : "R-DRE-2980808",
    "displayName" : "dab2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 22737 ],
    "identifier" : "A0A8M1P9G4",
    "standardIdentifier" : "uniprot:A0A8M1P9G4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dab2" ],
    "parents" : [ 10574159 ],
    "children" : [ ]
  }, {
    "dbId" : 10587532,
    "stId" : "R-DRE-112301",
    "displayName" : "Connexon 26 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 22741 ],
    "parents" : [ ],
    "children" : [ 10587530 ]
  }, {
    "dbId" : 10574159,
    "stId" : "R-DRE-196033",
    "displayName" : "planar gap junction plaques associated with Dab2 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 22738 ],
    "parents" : [ ],
    "children" : [ 10574157, 10574153 ]
  }, {
    "dbId" : 10573080,
    "stId" : "R-DRE-190544",
    "displayName" : "gja1 [Golgi-associated vesicle membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "O57474",
    "standardIdentifier" : "uniprot:O57474",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "gja1" ],
    "parents" : [ 10573082 ],
    "children" : [ ]
  }, {
    "dbId" : 10573082,
    "stId" : "R-DRE-190583",
    "displayName" : "Connexin 43 connexon in Golgi transport vesicle [Golgi-associated vesicle membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 68323,
    "diagramIds" : [ 22734 ],
    "parents" : [ ],
    "children" : [ 10573080 ]
  }, {
    "dbId" : 10572191,
    "stId" : "R-DRE-167585",
    "displayName" : "AP2M1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "identifier" : "Q6NWK2",
    "standardIdentifier" : "uniprot:Q6NWK2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10572197 ],
    "children" : [ ]
  }, {
    "dbId" : 10573086,
    "stId" : "R-DRE-190656",
    "displayName" : "gjb1a [endoplasmic reticulum membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 68323,
    "diagramIds" : [ 22730 ],
    "identifier" : "Q9DF29",
    "standardIdentifier" : "uniprot:Q9DF29",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "gjb1a" ],
    "parents" : [ 10573088 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10574161,
    "stId" : "R-DRE-196026",
    "displayName" : "Dab2 is recruited to the junctional plaques",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10574157, 10574153 ],
    "outputs" : [ 10574159 ],
    "efs" : [ ],
    "diagramIds" : [ 22735 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10573104,
    "stId" : "R-DRE-191072",
    "displayName" : "Synthesis of Cx43",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "outputs" : [ 10573102 ],
    "efs" : [ ],
    "diagramIds" : [ 22744 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10573091,
    "stId" : "R-DRE-190681",
    "displayName" : "Connexin oligomerization in endoplasmic reticulum membrane",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10573086 ],
    "outputs" : [ 10573088 ],
    "catalysts" : [ 10573086 ],
    "efs" : [ ],
    "diagramIds" : [ 22729 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10573190,
    "stId" : "R-DRE-191656",
    "displayName" : "Closure of gap junction",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10573188 ],
    "outputs" : [ 10573188 ],
    "efs" : [ ],
    "diagramIds" : [ 22742 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10573097,
    "stId" : "R-DRE-190782",
    "displayName" : "Budding of connexon-containing transport vesicles from the Golgi",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10573095 ],
    "outputs" : [ 10573082 ],
    "efs" : [ ],
    "diagramIds" : [ 22732 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10587534,
    "stId" : "R-DRE-451056",
    "displayName" : "Microtubule-independent trafficking of connexons to the plasma membrane",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10587528 ],
    "outputs" : [ 10587532 ],
    "efs" : [ ],
    "diagramIds" : [ 22739 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10648604,
    "stId" : "R-DRE-196025",
    "displayName" : "Formation of annular gap junctions",
    "events" : [ 10574161 ]
  }, {
    "dbId" : 10648512,
    "stId" : "R-DRE-190704",
    "displayName" : "Oligomerization of connexins into connexons",
    "events" : [ 10573091 ]
  }, {
    "dbId" : 10648524,
    "stId" : "R-DRE-190840",
    "displayName" : "Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane",
    "events" : [ 10573097 ]
  }, {
    "dbId" : 10648514,
    "stId" : "R-DRE-190861",
    "displayName" : "Gap junction assembly",
    "events" : [ 10573104, 10573091, 10573097, 10587534 ]
  }, {
    "dbId" : 10648516,
    "stId" : "R-DRE-190828",
    "displayName" : "Gap junction trafficking",
    "events" : [ 10573104, 10573091, 10573097, 10587534, 10574161 ]
  }, {
    "dbId" : 10648534,
    "stId" : "R-DRE-191650",
    "displayName" : "Regulation of gap junction activity",
    "events" : [ 10573190 ]
  }, {
    "dbId" : 10648526,
    "stId" : "R-DRE-190872",
    "displayName" : "Transport of connexons to the plasma membrane",
    "events" : [ 10573097, 10587534 ]
  }, {
    "dbId" : 10648606,
    "stId" : "R-DRE-190873",
    "displayName" : "Gap junction degradation",
    "events" : [ 10574161 ]
  } ]
}