{
  "dbId" : 10649232,
  "stableId" : "R-DRE-1266695",
  "displayName" : "Interleukin-7 signaling",
  "nodes" : [ {
    "id" : 39840,
    "reactomeId" : 10636504,
    "displayName" : "IL7:p-Y449-IL7R:JAK1:p-FYN:IL2RG:JAK3:PI3K-regulatory subunits",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 90,
      "y" : 335
    },
    "minX" : 10,
    "maxX" : 177,
    "minY" : 303,
    "maxY" : 398,
    "prop" : {
      "x" : 10,
      "y" : 309,
      "width" : 161,
      "height" : 53
    },
    "textPosition" : {
      "x" : 17,
      "y" : 313
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 171,
          "y" : 309
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 171,
          "y" : 309
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39839,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 90,
          "y" : 365
        },
        "to" : {
          "x" : 90,
          "y" : 398
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39841,
    "reactomeId" : 10563990,
    "displayName" : "IRS1,2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 204,
      "y" : 382
    },
    "minX" : 90,
    "maxX" : 227,
    "minY" : 371,
    "maxY" : 398,
    "prop" : {
      "x" : 182,
      "y" : 371,
      "width" : 45,
      "height" : 22
    },
    "textPosition" : {
      "x" : 185,
      "y" : 365
    },
    "connectors" : [ {
      "edgeId" : 39839,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 176,
          "y" : 385
        },
        "to" : {
          "x" : 90,
          "y" : 398
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39842,
    "reactomeId" : 10636506,
    "displayName" : "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 90,
      "y" : 495
    },
    "minX" : 0,
    "maxX" : 186,
    "minY" : 464,
    "maxY" : 521,
    "prop" : {
      "x" : 0,
      "y" : 470,
      "width" : 180,
      "height" : 51
    },
    "textPosition" : {
      "x" : 3,
      "y" : 472
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 180,
          "y" : 470
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 180,
          "y" : 470
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39839,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39844,
    "reactomeId" : 10636514,
    "displayName" : "IL7:IL7R:JAK1:IL2RG:JAK3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 660,
      "y" : 51
    },
    "minX" : 602,
    "maxX" : 762,
    "minY" : 11,
    "maxY" : 75,
    "prop" : {
      "x" : 602,
      "y" : 32,
      "width" : 116,
      "height" : 38
    },
    "textPosition" : {
      "x" : 616,
      "y" : 35
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 718,
          "y" : 32
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 718,
          "y" : 32
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39843,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 721,
          "y" : 69
        },
        "to" : {
          "x" : 734,
          "y" : 75
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 39843,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 707,
          "y" : 29
        },
        "to" : {
          "x" : 759,
          "y" : 11
        }
      }, {
        "from" : {
          "x" : 759,
          "y" : 11
        },
        "to" : {
          "x" : 758,
          "y" : 57
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 758,
          "y" : 61
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 758,
          "y" : 61
        }
      }
    } ]
  }, {
    "id" : 39845,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 718,
      "y" : 109
    },
    "minX" : 699,
    "maxX" : 738,
    "minY" : 75,
    "maxY" : 125,
    "prop" : {
      "x" : 699,
      "y" : 93,
      "width" : 38,
      "height" : 32
    },
    "textPosition" : {
      "x" : 702,
      "y" : 98
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 732,
          "y" : 98
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 732,
          "y" : 98
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39843,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 725,
          "y" : 90
        },
        "to" : {
          "x" : 734,
          "y" : 75
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39846,
    "reactomeId" : 10636516,
    "displayName" : "IL7:IL7R:JAK1:IL2RG:p-JAK3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 859,
      "y" : 48
    },
    "minX" : 780,
    "maxX" : 927,
    "minY" : 22,
    "maxY" : 76,
    "prop" : {
      "x" : 798,
      "y" : 28,
      "width" : 123,
      "height" : 40
    },
    "textPosition" : {
      "x" : 815,
      "y" : 33
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 921,
          "y" : 28
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 921,
          "y" : 28
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39843,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 800,
          "y" : 71
        },
        "to" : {
          "x" : 780,
          "y" : 75
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 794,
          "y" : 76
        },
        "b" : {
          "x" : 800,
          "y" : 71
        },
        "c" : {
          "x" : 792,
          "y" : 68
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 792,
          "y" : 68
        }
      }
    } ]
  }, {
    "id" : 39847,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 813,
      "y" : 114
    },
    "minX" : 780,
    "maxX" : 834,
    "minY" : 75,
    "maxY" : 129,
    "prop" : {
      "x" : 794,
      "y" : 99,
      "width" : 39,
      "height" : 30
    },
    "textPosition" : {
      "x" : 797,
      "y" : 103
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 828,
          "y" : 104
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 828,
          "y" : 104
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39843,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 800,
          "y" : 96
        },
        "to" : {
          "x" : 780,
          "y" : 75
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 792,
          "y" : 94
        },
        "b" : {
          "x" : 800,
          "y" : 96
        },
        "c" : {
          "x" : 798,
          "y" : 88
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 798,
          "y" : 88
        }
      }
    } ]
  }, {
    "id" : 39849,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1328,
      "y" : 114
    },
    "minX" : 1310,
    "maxX" : 1359,
    "minY" : 74,
    "maxY" : 129,
    "prop" : {
      "x" : 1310,
      "y" : 99,
      "width" : 36,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1312,
      "y" : 103
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1341,
          "y" : 104
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1341,
          "y" : 104
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39848,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1339,
          "y" : 96
        },
        "to" : {
          "x" : 1359,
          "y" : 74
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39850,
    "reactomeId" : 10594595,
    "displayName" : "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1274,
      "y" : 39
    },
    "minX" : 1215,
    "maxX" : 1385,
    "minY" : 0,
    "maxY" : 74,
    "prop" : {
      "x" : 1215,
      "y" : 6,
      "width" : 119,
      "height" : 66
    },
    "textPosition" : {
      "x" : 1215,
      "y" : 23
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1334,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1334,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39848,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1337,
          "y" : 63
        },
        "to" : {
          "x" : 1359,
          "y" : 74
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 39848,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1337,
          "y" : 33
        },
        "to" : {
          "x" : 1378,
          "y" : 30
        }
      }, {
        "from" : {
          "x" : 1378,
          "y" : 30
        },
        "to" : {
          "x" : 1381,
          "y" : 59
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1381,
          "y" : 63
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1381,
          "y" : 63
        }
      }
    }, {
      "edgeId" : 39853,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39851,
    "reactomeId" : 10594597,
    "displayName" : "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1500,
      "y" : 49
    },
    "minX" : 1406,
    "maxX" : 1568,
    "minY" : 11,
    "maxY" : 81,
    "prop" : {
      "x" : 1438,
      "y" : 17,
      "width" : 124,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1441,
      "y" : 18
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1562,
          "y" : 17
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1562,
          "y" : 17
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39856,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 39848,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1435,
          "y" : 66
        },
        "to" : {
          "x" : 1406,
          "y" : 75
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1430,
          "y" : 72
        },
        "b" : {
          "x" : 1435,
          "y" : 66
        },
        "c" : {
          "x" : 1427,
          "y" : 64
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1427,
          "y" : 64
        }
      }
    } ]
  }, {
    "id" : 39852,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1462,
      "y" : 114
    },
    "minX" : 1406,
    "maxX" : 1484,
    "minY" : 75,
    "maxY" : 129,
    "prop" : {
      "x" : 1441,
      "y" : 99,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1445,
      "y" : 103
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1478,
          "y" : 104
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1478,
          "y" : 104
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39848,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1438,
          "y" : 99
        },
        "to" : {
          "x" : 1406,
          "y" : 75
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1430,
          "y" : 98
        },
        "b" : {
          "x" : 1438,
          "y" : 99
        },
        "c" : {
          "x" : 1435,
          "y" : 92
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1435,
          "y" : 92
        }
      }
    } ]
  }, {
    "id" : 39854,
    "reactomeId" : 10594591,
    "displayName" : "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1052,
      "y" : 49
    },
    "minX" : 981,
    "maxX" : 1543,
    "minY" : 24,
    "maxY" : 178,
    "prop" : {
      "x" : 981,
      "y" : 30,
      "width" : 143,
      "height" : 38
    },
    "textPosition" : {
      "x" : 985,
      "y" : 33
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1124,
          "y" : 30
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1124,
          "y" : 30
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39856,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1054,
          "y" : 71
        },
        "to" : {
          "x" : 1066,
          "y" : 178
        }
      }, {
        "from" : {
          "x" : 1066,
          "y" : 178
        },
        "to" : {
          "x" : 1543,
          "y" : 176
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1059,
          "y" : 77
        },
        "b" : {
          "x" : 1054,
          "y" : 71
        },
        "c" : {
          "x" : 1051,
          "y" : 78
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1051,
          "y" : 78
        }
      }
    }, {
      "edgeId" : 39853,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1127,
          "y" : 66
        },
        "to" : {
          "x" : 1145,
          "y" : 72
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39855,
    "reactomeId" : 10594593,
    "displayName" : "STAT5A,STAT5B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1132,
      "y" : 124
    },
    "minX" : 1084,
    "maxX" : 1181,
    "minY" : 72,
    "maxY" : 141,
    "prop" : {
      "x" : 1084,
      "y" : 107,
      "width" : 97,
      "height" : 34
    },
    "textPosition" : {
      "x" : 1103,
      "y" : 107
    },
    "connectors" : [ {
      "edgeId" : 39853,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1136,
          "y" : 101
        },
        "to" : {
          "x" : 1145,
          "y" : 72
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39857,
    "reactomeId" : 10593252,
    "displayName" : "p-STAT5A, p-STAT5B",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1661,
      "y" : 55
    },
    "minX" : 1543,
    "maxX" : 1731,
    "minY" : 44,
    "maxY" : 176,
    "prop" : {
      "x" : 1591,
      "y" : 44,
      "width" : 140,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1595,
      "y" : 44
    },
    "connectors" : [ {
      "edgeId" : 39856,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1650,
          "y" : 72
        },
        "to" : {
          "x" : 1543,
          "y" : 176
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1648,
          "y" : 80
        },
        "b" : {
          "x" : 1650,
          "y" : 72
        },
        "c" : {
          "x" : 1642,
          "y" : 74
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1642,
          "y" : 74
        }
      }
    } ]
  }, {
    "id" : 39859,
    "reactomeId" : 9678772,
    "displayName" : "JAK3 inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 298,
      "y" : 160
    },
    "minX" : 251,
    "maxX" : 382,
    "minY" : 149,
    "maxY" : 171,
    "prop" : {
      "x" : 251,
      "y" : 149,
      "width" : 94,
      "height" : 22
    },
    "textPosition" : {
      "x" : 265,
      "y" : 143
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 39858,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 351,
          "y" : 159
        },
        "to" : {
          "x" : 382,
          "y" : 159
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39835,
    "reactomeId" : 10587062,
    "displayName" : "JAK3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 447,
      "y" : 109
    },
    "minX" : 382,
    "maxX" : 475,
    "minY" : 81,
    "maxY" : 159,
    "prop" : {
      "x" : 426,
      "y" : 98,
      "width" : 43,
      "height" : 23
    },
    "textPosition" : {
      "x" : 430,
      "y" : 99
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 469,
          "y" : 98
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 469,
          "y" : 98
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39858,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 432,
          "y" : 124
        },
        "to" : {
          "x" : 382,
          "y" : 159
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 39834,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 454,
          "y" : 95
        },
        "to" : {
          "x" : 466,
          "y" : 81
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39836,
    "reactomeId" : 10587058,
    "displayName" : "il2rga",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 446,
      "y" : 53
    },
    "minX" : 425,
    "maxX" : 474,
    "minY" : 36,
    "maxY" : 81,
    "prop" : {
      "x" : 425,
      "y" : 42,
      "width" : 43,
      "height" : 22
    },
    "textPosition" : {
      "x" : 425,
      "y" : 42
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 468,
          "y" : 42
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 468,
          "y" : 42
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39834,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 453,
          "y" : 67
        },
        "to" : {
          "x" : 466,
          "y" : 81
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39837,
    "reactomeId" : 10587064,
    "displayName" : "IL2RG:JAK3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 549,
      "y" : 52
    },
    "minX" : 512,
    "maxX" : 592,
    "minY" : 35,
    "maxY" : 63,
    "prop" : {
      "x" : 512,
      "y" : 41,
      "width" : 74,
      "height" : 22
    },
    "textPosition" : {
      "x" : 513,
      "y" : 42
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 586,
          "y" : 41
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 586,
          "y" : 41
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39834,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 39838,
    "reactomeId" : 10587611,
    "displayName" : "JAK3:JAK3 inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 500,
      "y" : 160
    },
    "minX" : 437,
    "maxX" : 569,
    "minY" : 90,
    "maxY" : 171,
    "prop" : {
      "x" : 437,
      "y" : 149,
      "width" : 126,
      "height" : 22
    },
    "textPosition" : {
      "x" : 437,
      "y" : 150
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 563,
          "y" : 149
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 563,
          "y" : 149
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 39858,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 39834,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 500,
          "y" : 146
        },
        "to" : {
          "x" : 500,
          "y" : 90
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 496,
          "y" : 90
        },
        "b" : {
          "x" : 504,
          "y" : 90
        },
        "c" : {
          "x" : 500,
          "y" : 90
        },
        "type" : "STOP",
        "centre" : {
          "x" : 500,
          "y" : 90
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 39856,
    "reactomeId" : 10621295,
    "displayName" : "p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1524,
      "y" : 130
    },
    "minX" : 1509,
    "maxX" : 1543,
    "minY" : 84,
    "maxY" : 176,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 1509,
        "y" : 84
      },
      "to" : {
        "x" : 1524,
        "y" : 130
      }
    }, {
      "from" : {
        "x" : 1524,
        "y" : 130
      },
      "to" : {
        "x" : 1543,
        "y" : 176
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1524,
        "y" : 130
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 1524,
        "y" : 130
      }
    },
    "inputs" : [ {
      "id" : 39851
    } ],
    "outputs" : [ {
      "id" : 39854,
      "points" : [ {
        "x" : 1054,
        "y" : 71
      }, {
        "x" : 1066,
        "y" : 178
      } ]
    }, {
      "id" : 39857,
      "points" : [ {
        "x" : 1650,
        "y" : 72
      } ]
    } ]
  }, {
    "id" : 39858,
    "reactomeId" : 10640224,
    "displayName" : "JAK3 binds JAK3 inhibitors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 408,
      "y" : 159
    },
    "minX" : 376,
    "maxX" : 434,
    "minY" : 153,
    "maxY" : 165,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 382,
        "y" : 159
      },
      "to" : {
        "x" : 408,
        "y" : 159
      }
    }, {
      "from" : {
        "x" : 408,
        "y" : 159
      },
      "to" : {
        "x" : 434,
        "y" : 159
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 427,
        "y" : 163
      },
      "b" : {
        "x" : 434,
        "y" : 159
      },
      "c" : {
        "x" : 427,
        "y" : 155
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 427,
        "y" : 155
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 408,
        "y" : 159
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 408,
        "y" : 159
      }
    },
    "inputs" : [ {
      "id" : 39835,
      "points" : [ {
        "x" : 432,
        "y" : 124
      } ]
    }, {
      "id" : 39859,
      "points" : [ {
        "x" : 351,
        "y" : 159
      } ]
    } ],
    "outputs" : [ {
      "id" : 39838
    } ]
  }, {
    "id" : 39843,
    "reactomeId" : 10636519,
    "displayName" : "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 758,
      "y" : 73
    },
    "minX" : 734,
    "maxX" : 780,
    "minY" : 67,
    "maxY" : 79,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 734,
        "y" : 75
      },
      "to" : {
        "x" : 758,
        "y" : 73
      }
    }, {
      "from" : {
        "x" : 758,
        "y" : 73
      },
      "to" : {
        "x" : 780,
        "y" : 75
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 752,
        "y" : 67
      },
      "b" : {
        "x" : 764,
        "y" : 79
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 758,
        "y" : 73
      }
    },
    "inputs" : [ {
      "id" : 39844,
      "points" : [ {
        "x" : 721,
        "y" : 69
      } ]
    }, {
      "id" : 39845,
      "points" : [ {
        "x" : 725,
        "y" : 90
      } ]
    } ],
    "outputs" : [ {
      "id" : 39846,
      "points" : [ {
        "x" : 800,
        "y" : 71
      } ]
    }, {
      "id" : 39847,
      "points" : [ {
        "x" : 800,
        "y" : 96
      } ]
    } ],
    "catalysts" : [ {
      "id" : 39844,
      "points" : [ {
        "x" : 707,
        "y" : 29
      }, {
        "x" : 759,
        "y" : 11
      } ]
    } ]
  }, {
    "id" : 39848,
    "reactomeId" : 10594600,
    "displayName" : "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1382,
      "y" : 75
    },
    "minX" : 1359,
    "maxX" : 1406,
    "minY" : 69,
    "maxY" : 81,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1359,
        "y" : 74
      },
      "to" : {
        "x" : 1382,
        "y" : 75
      }
    }, {
      "from" : {
        "x" : 1382,
        "y" : 75
      },
      "to" : {
        "x" : 1406,
        "y" : 75
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1376,
        "y" : 69
      },
      "b" : {
        "x" : 1388,
        "y" : 81
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1382,
        "y" : 75
      }
    },
    "inputs" : [ {
      "id" : 39849,
      "points" : [ {
        "x" : 1339,
        "y" : 96
      } ]
    }, {
      "id" : 39850,
      "points" : [ {
        "x" : 1337,
        "y" : 63
      } ]
    } ],
    "outputs" : [ {
      "id" : 39851,
      "points" : [ {
        "x" : 1435,
        "y" : 66
      } ]
    }, {
      "id" : 39852,
      "points" : [ {
        "x" : 1438,
        "y" : 99
      } ]
    } ],
    "catalysts" : [ {
      "id" : 39850,
      "points" : [ {
        "x" : 1337,
        "y" : 33
      }, {
        "x" : 1378,
        "y" : 30
      } ]
    } ]
  }, {
    "id" : 39834,
    "reactomeId" : 10587613,
    "displayName" : "IL2RG binds JAK3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 500,
      "y" : 81
    },
    "minX" : 466,
    "maxX" : 530,
    "minY" : 66,
    "maxY" : 87,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 466,
        "y" : 81
      },
      "to" : {
        "x" : 500,
        "y" : 81
      }
    }, {
      "from" : {
        "x" : 500,
        "y" : 81
      },
      "to" : {
        "x" : 530,
        "y" : 66
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 526,
        "y" : 73
      },
      "b" : {
        "x" : 530,
        "y" : 66
      },
      "c" : {
        "x" : 522,
        "y" : 66
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 522,
        "y" : 66
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 500,
        "y" : 81
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 500,
        "y" : 81
      }
    },
    "inputs" : [ {
      "id" : 39835,
      "points" : [ {
        "x" : 454,
        "y" : 95
      } ]
    }, {
      "id" : 39836,
      "points" : [ {
        "x" : 453,
        "y" : 67
      } ]
    } ],
    "outputs" : [ {
      "id" : 39837
    } ],
    "inhibitors" : [ {
      "id" : 39838,
      "points" : [ {
        "x" : 500,
        "y" : 146
      } ]
    } ]
  }, {
    "id" : 39853,
    "reactomeId" : 10638302,
    "displayName" : "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1177,
      "y" : 71
    },
    "minX" : 1145,
    "maxX" : 1212,
    "minY" : 58,
    "maxY" : 77,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1145,
        "y" : 72
      },
      "to" : {
        "x" : 1177,
        "y" : 71
      }
    }, {
      "from" : {
        "x" : 1177,
        "y" : 71
      },
      "to" : {
        "x" : 1212,
        "y" : 58
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1207,
        "y" : 64
      },
      "b" : {
        "x" : 1212,
        "y" : 58
      },
      "c" : {
        "x" : 1204,
        "y" : 57
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1204,
        "y" : 57
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1171,
        "y" : 65
      },
      "b" : {
        "x" : 1183,
        "y" : 77
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1177,
        "y" : 71
      }
    },
    "inputs" : [ {
      "id" : 39854,
      "points" : [ {
        "x" : 1127,
        "y" : 66
      } ]
    }, {
      "id" : 39855,
      "points" : [ {
        "x" : 1136,
        "y" : 101
      } ]
    } ],
    "outputs" : [ {
      "id" : 39850
    } ]
  }, {
    "id" : 39839,
    "reactomeId" : 10636508,
    "displayName" : "IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 90,
      "y" : 431
    },
    "minX" : 84,
    "maxX" : 96,
    "minY" : 398,
    "maxY" : 467,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 90,
        "y" : 398
      },
      "to" : {
        "x" : 90,
        "y" : 431
      }
    }, {
      "from" : {
        "x" : 90,
        "y" : 431
      },
      "to" : {
        "x" : 90,
        "y" : 467
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 86,
        "y" : 460
      },
      "b" : {
        "x" : 90,
        "y" : 467
      },
      "c" : {
        "x" : 94,
        "y" : 460
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 94,
        "y" : 460
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 84,
        "y" : 425
      },
      "b" : {
        "x" : 96,
        "y" : 437
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 90,
        "y" : 431
      }
    },
    "inputs" : [ {
      "id" : 39840,
      "points" : [ {
        "x" : 90,
        "y" : 365
      } ]
    }, {
      "id" : 39841,
      "points" : [ {
        "x" : 176,
        "y" : 385
      } ]
    } ],
    "outputs" : [ {
      "id" : 39842
    } ]
  } ],
  "compartments" : [ {
    "id" : 39861,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1015,
      "y" : 504
    },
    "minX" : 50,
    "maxX" : 1981,
    "minY" : 46,
    "maxY" : 962,
    "prop" : {
      "x" : 50,
      "y" : 46,
      "width" : 1931,
      "height" : 916
    },
    "textPosition" : {
      "x" : 98,
      "y" : 904
    },
    "insets" : {
      "x" : 60,
      "y" : 56,
      "width" : 1911,
      "height" : 896
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 39837, 39834, 39835, 39836, 39840, 39842, 39839, 39844, 39846, 39847, 39845, 39843, 39854, 39848, 39850, 39855, 39853, 39857, 39851, 39852, 39849, 39856, 39869, 39841, 39838, 39858, 39859 ]
  }, {
    "id" : 39869,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1492,
      "y" : 624
    },
    "minX" : 1038,
    "maxX" : 1947,
    "minY" : 353,
    "maxY" : 896,
    "prop" : {
      "x" : 1038,
      "y" : 353,
      "width" : 909,
      "height" : 543
    },
    "textPosition" : {
      "x" : 1083,
      "y" : 758
    },
    "insets" : {
      "x" : 1048,
      "y" : 363,
      "width" : 889,
      "height" : 523
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1981,
  "minY" : 0,
  "maxY" : 962,
  "disease" : false
}