{
  "dbId" : 10649412,
  "stableId" : "R-DRE-1227986",
  "displayName" : "Signaling by ERBB2",
  "nodes" : [ {
    "id" : 93575,
    "reactomeId" : 10594256,
    "displayName" : "NRG1/2",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1272,
      "y" : 10
    },
    "minX" : 1244,
    "maxX" : 1300,
    "minY" : 0,
    "maxY" : 102,
    "prop" : {
      "x" : 1244,
      "y" : 0,
      "width" : 56,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1245,
      "y" : 0
    },
    "connectors" : [ {
      "edgeId" : 93574,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1272,
          "y" : 27
        },
        "to" : {
          "x" : 1280,
          "y" : 102
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93577,
    "reactomeId" : 10594258,
    "displayName" : "NRG1/2:ERBB3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1118,
      "y" : 110
    },
    "minX" : 1082,
    "maxX" : 1160,
    "minY" : 84,
    "maxY" : 130,
    "prop" : {
      "x" : 1082,
      "y" : 90,
      "width" : 72,
      "height" : 40
    },
    "textPosition" : {
      "x" : 1089,
      "y" : 95
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1154,
          "y" : 90
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1154,
          "y" : 90
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93574,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93576,
    "reactomeId" : 10594252,
    "displayName" : "ERBB3-1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1838,
      "y" : 261
    },
    "minX" : 1280,
    "maxX" : 2096,
    "minY" : 102,
    "maxY" : 277,
    "prop" : {
      "x" : 1801,
      "y" : 245,
      "width" : 75,
      "height" : 32
    },
    "textPosition" : {
      "x" : 1808,
      "y" : 250
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1876,
          "y" : 245
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1876,
          "y" : 245
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93574,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1825,
          "y" : 242
        },
        "to" : {
          "x" : 1725,
          "y" : 115
        }
      }, {
        "from" : {
          "x" : 1725,
          "y" : 115
        },
        "to" : {
          "x" : 1280,
          "y" : 102
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93600,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1879,
          "y" : 262
        },
        "to" : {
          "x" : 2061,
          "y" : 272
        }
      }, {
        "from" : {
          "x" : 2061,
          "y" : 272
        },
        "to" : {
          "x" : 2096,
          "y" : 271
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93579,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1901,
      "y" : 1004
    },
    "minX" : 1881,
    "maxX" : 1922,
    "minY" : 988,
    "maxY" : 1060,
    "prop" : {
      "x" : 1881,
      "y" : 989,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1885,
      "y" : 993
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1916,
          "y" : 994
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1916,
          "y" : 994
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93578,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1898,
          "y" : 1022
        },
        "to" : {
          "x" : 1891,
          "y" : 1060
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1888,
            "y" : 1035
          },
          "b" : {
            "x" : 1900,
            "y" : 1047
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1894,
            "y" : 1041
          }
        }
      }
    } ]
  }, {
    "id" : 93581,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1821,
      "y" : 994
    },
    "minX" : 1800,
    "maxX" : 1843,
    "minY" : 978,
    "maxY" : 1059,
    "prop" : {
      "x" : 1800,
      "y" : 979,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1804,
      "y" : 983
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1837,
          "y" : 984
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1837,
          "y" : 984
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93578,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1822,
          "y" : 1012
        },
        "to" : {
          "x" : 1827,
          "y" : 1059
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1818,
            "y" : 1029
          },
          "b" : {
            "x" : 1830,
            "y" : 1041
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1824,
            "y" : 1035
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1827,
          "y" : 1018
        },
        "b" : {
          "x" : 1822,
          "y" : 1012
        },
        "c" : {
          "x" : 1819,
          "y" : 1019
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1819,
          "y" : 1019
        }
      }
    } ]
  }, {
    "id" : 93580,
    "reactomeId" : 10594396,
    "displayName" : "SHC1:Phosphorylated ERBB2 heterodimers",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1998,
      "y" : 1051
    },
    "minX" : 1836,
    "maxX" : 2068,
    "minY" : 1018,
    "maxY" : 1113,
    "prop" : {
      "x" : 1935,
      "y" : 1024,
      "width" : 127,
      "height" : 54
    },
    "textPosition" : {
      "x" : 1943,
      "y" : 1015
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2062,
          "y" : 1024
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2062,
          "y" : 1024
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93578,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1932,
          "y" : 1056
        },
        "to" : {
          "x" : 1891,
          "y" : 1060
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93578,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1986,
          "y" : 1081
        },
        "to" : {
          "x" : 1971,
          "y" : 1112
        }
      }, {
        "from" : {
          "x" : 1971,
          "y" : 1112
        },
        "to" : {
          "x" : 1836,
          "y" : 1113
        }
      }, {
        "from" : {
          "x" : 1836,
          "y" : 1113
        },
        "to" : {
          "x" : 1854,
          "y" : 1073
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1856,
          "y" : 1069
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1856,
          "y" : 1069
        }
      }
    } ]
  }, {
    "id" : 93582,
    "reactomeId" : 10594398,
    "displayName" : "p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1748,
      "y" : 1078
    },
    "minX" : 1698,
    "maxX" : 1827,
    "minY" : 1033,
    "maxY" : 1118,
    "prop" : {
      "x" : 1698,
      "y" : 1039,
      "width" : 100,
      "height" : 79
    },
    "textPosition" : {
      "x" : 1699,
      "y" : 1041
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1798,
          "y" : 1039
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1798,
          "y" : 1039
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93578,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1801,
          "y" : 1065
        },
        "to" : {
          "x" : 1827,
          "y" : 1059
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1807,
          "y" : 1060
        },
        "b" : {
          "x" : 1801,
          "y" : 1065
        },
        "c" : {
          "x" : 1809,
          "y" : 1067
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1809,
          "y" : 1067
        }
      }
    } ]
  }, {
    "id" : 93585,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2864,
      "y" : 678
    },
    "minX" : 2845,
    "maxX" : 2945,
    "minY" : 663,
    "maxY" : 691,
    "prop" : {
      "x" : 2845,
      "y" : 666,
      "width" : 39,
      "height" : 25
    },
    "textPosition" : {
      "x" : 2849,
      "y" : 668
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2879,
          "y" : 671
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2879,
          "y" : 671
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93583,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2887,
          "y" : 673
        },
        "to" : {
          "x" : 2930,
          "y" : 663
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93593,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2887,
          "y" : 675
        },
        "to" : {
          "x" : 2945,
          "y" : 668
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93584,
    "reactomeId" : 179856,
    "displayName" : "PI(4,5)P2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2951,
      "y" : 623
    },
    "minX" : 2920,
    "maxX" : 2984,
    "minY" : 608,
    "maxY" : 668,
    "prop" : {
      "x" : 2920,
      "y" : 609,
      "width" : 63,
      "height" : 29
    },
    "textPosition" : {
      "x" : 2927,
      "y" : 606
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2978,
          "y" : 614
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2978,
          "y" : 614
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93583,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2943,
          "y" : 641
        },
        "to" : {
          "x" : 2930,
          "y" : 663
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93593,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2949,
          "y" : 641
        },
        "to" : {
          "x" : 2945,
          "y" : 668
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93587,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2881,
      "y" : 767
    },
    "minX" : 2862,
    "maxX" : 2957,
    "minY" : 746,
    "maxY" : 779,
    "prop" : {
      "x" : 2862,
      "y" : 756,
      "width" : 38,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2864,
      "y" : 757
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2895,
          "y" : 761
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2895,
          "y" : 761
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93583,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2903,
          "y" : 761
        },
        "to" : {
          "x" : 2949,
          "y" : 746
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2908,
          "y" : 755
        },
        "b" : {
          "x" : 2903,
          "y" : 761
        },
        "c" : {
          "x" : 2911,
          "y" : 763
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2911,
          "y" : 763
        }
      }
    }, {
      "edgeId" : 93593,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2903,
          "y" : 763
        },
        "to" : {
          "x" : 2957,
          "y" : 751
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2909,
          "y" : 758
        },
        "b" : {
          "x" : 2903,
          "y" : 763
        },
        "c" : {
          "x" : 2911,
          "y" : 765
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2911,
          "y" : 765
        }
      }
    } ]
  }, {
    "id" : 93586,
    "reactomeId" : 179838,
    "displayName" : "PI(3,4,5)P3",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2954,
      "y" : 837
    },
    "minX" : 2914,
    "maxX" : 2996,
    "minY" : 746,
    "maxY" : 852,
    "prop" : {
      "x" : 2914,
      "y" : 822,
      "width" : 81,
      "height" : 30
    },
    "textPosition" : {
      "x" : 2916,
      "y" : 826
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2990,
          "y" : 827
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2990,
          "y" : 827
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93583,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2953,
          "y" : 819
        },
        "to" : {
          "x" : 2949,
          "y" : 746
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2949,
          "y" : 812
        },
        "b" : {
          "x" : 2953,
          "y" : 819
        },
        "c" : {
          "x" : 2957,
          "y" : 812
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2957,
          "y" : 812
        }
      }
    }, {
      "edgeId" : 93593,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2954,
          "y" : 819
        },
        "to" : {
          "x" : 2957,
          "y" : 751
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2950,
          "y" : 812
        },
        "b" : {
          "x" : 2954,
          "y" : 819
        },
        "c" : {
          "x" : 2958,
          "y" : 812
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2958,
          "y" : 812
        }
      }
    } ]
  }, {
    "id" : 93588,
    "reactomeId" : 10594344,
    "displayName" : "NRG1/2:p-ERBB3:p-ERBB2:PI3K",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2944,
      "y" : 555
    },
    "minX" : 2911,
    "maxX" : 3031,
    "minY" : 519,
    "maxY" : 712,
    "prop" : {
      "x" : 2911,
      "y" : 525,
      "width" : 66,
      "height" : 61
    },
    "textPosition" : {
      "x" : 2912,
      "y" : 523
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2977,
          "y" : 525
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2977,
          "y" : 525
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93583,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2980,
          "y" : 556
        },
        "to" : {
          "x" : 3031,
          "y" : 560
        }
      }, {
        "from" : {
          "x" : 3031,
          "y" : 560
        },
        "to" : {
          "x" : 3026,
          "y" : 707
        }
      }, {
        "from" : {
          "x" : 3026,
          "y" : 707
        },
        "to" : {
          "x" : 2964,
          "y" : 708
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2960,
          "y" : 708
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2960,
          "y" : 708
        }
      }
    }, {
      "edgeId" : 93661,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93591,
    "reactomeId" : 10572319,
    "displayName" : "PIK3CA:PIK3R1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2898,
      "y" : 319
    },
    "minX" : 2817,
    "maxX" : 2933,
    "minY" : 294,
    "maxY" : 480,
    "prop" : {
      "x" : 2869,
      "y" : 300,
      "width" : 58,
      "height" : 39
    },
    "textPosition" : {
      "x" : 2871,
      "y" : 304
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2927,
          "y" : 300
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2927,
          "y" : 300
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93589,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2893,
          "y" : 342
        },
        "to" : {
          "x" : 2878,
          "y" : 399
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93661,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2888,
          "y" : 342
        },
        "to" : {
          "x" : 2817,
          "y" : 480
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93590,
    "reactomeId" : 10594442,
    "displayName" : "Phosphorylated ERBB2:ERBB4cyt1 heterodimers",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2745,
      "y" : 350
    },
    "minX" : 2682,
    "maxX" : 2878,
    "minY" : 323,
    "maxY" : 399,
    "prop" : {
      "x" : 2682,
      "y" : 323,
      "width" : 126,
      "height" : 55
    },
    "textPosition" : {
      "x" : 2684,
      "y" : 326
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 93589,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2814,
          "y" : 373
        },
        "to" : {
          "x" : 2878,
          "y" : 399
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93592,
    "reactomeId" : 10594444,
    "displayName" : "NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2973,
      "y" : 420
    },
    "minX" : 2926,
    "maxX" : 3075,
    "minY" : 391,
    "maxY" : 694,
    "prop" : {
      "x" : 2926,
      "y" : 397,
      "width" : 95,
      "height" : 46
    },
    "textPosition" : {
      "x" : 2928,
      "y" : 394
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3021,
          "y" : 397
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3021,
          "y" : 397
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93589,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93593,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3024,
          "y" : 418
        },
        "to" : {
          "x" : 3075,
          "y" : 417
        }
      }, {
        "from" : {
          "x" : 3075,
          "y" : 417
        },
        "to" : {
          "x" : 3073,
          "y" : 663
        }
      }, {
        "from" : {
          "x" : 3073,
          "y" : 663
        },
        "to" : {
          "x" : 2996,
          "y" : 689
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2992,
          "y" : 690
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2992,
          "y" : 690
        }
      }
    } ]
  }, {
    "id" : 93595,
    "reactomeId" : 10572353,
    "displayName" : "p21 RAS:GDP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1340,
      "y" : 1096
    },
    "minX" : 1320,
    "maxX" : 1381,
    "minY" : 1066,
    "maxY" : 1120,
    "prop" : {
      "x" : 1320,
      "y" : 1072,
      "width" : 41,
      "height" : 48
    },
    "textPosition" : {
      "x" : 1322,
      "y" : 1071
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1361,
          "y" : 1072
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1361,
          "y" : 1072
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93594,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1364,
          "y" : 1082
        },
        "to" : {
          "x" : 1381,
          "y" : 1068
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93597,
    "reactomeId" : 29420,
    "displayName" : "GDP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1438,
      "y" : 1005
    },
    "minX" : 1417,
    "maxX" : 1461,
    "minY" : 995,
    "maxY" : 1080,
    "prop" : {
      "x" : 1417,
      "y" : 996,
      "width" : 43,
      "height" : 19
    },
    "textPosition" : {
      "x" : 1421,
      "y" : 995
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1455,
          "y" : 1001
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1455,
          "y" : 1001
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93594,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1437,
          "y" : 1018
        },
        "to" : {
          "x" : 1433,
          "y" : 1080
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1441,
          "y" : 1025
        },
        "b" : {
          "x" : 1437,
          "y" : 1018
        },
        "c" : {
          "x" : 1433,
          "y" : 1025
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1433,
          "y" : 1025
        }
      }
    } ]
  }, {
    "id" : 93596,
    "reactomeId" : 29438,
    "displayName" : "GTP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1379,
      "y" : 1008
    },
    "minX" : 1361,
    "maxX" : 1398,
    "minY" : 998,
    "maxY" : 1068,
    "prop" : {
      "x" : 1361,
      "y" : 999,
      "width" : 36,
      "height" : 18
    },
    "textPosition" : {
      "x" : 1363,
      "y" : 998
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1392,
          "y" : 1004
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1392,
          "y" : 1004
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93594,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1379,
          "y" : 1020
        },
        "to" : {
          "x" : 1381,
          "y" : 1068
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93599,
    "reactomeId" : 10594928,
    "displayName" : "NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2129,
      "y" : 1053
    },
    "minX" : 1407,
    "maxX" : 2177,
    "minY" : 1017,
    "maxY" : 1167,
    "prop" : {
      "x" : 2087,
      "y" : 1023,
      "width" : 84,
      "height" : 61
    },
    "textPosition" : {
      "x" : 2088,
      "y" : 1021
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2171,
          "y" : 1023
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2171,
          "y" : 1023
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93594,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2123,
          "y" : 1087
        },
        "to" : {
          "x" : 2108,
          "y" : 1162
        }
      }, {
        "from" : {
          "x" : 2108,
          "y" : 1162
        },
        "to" : {
          "x" : 1411,
          "y" : 1167
        }
      }, {
        "from" : {
          "x" : 1411,
          "y" : 1167
        },
        "to" : {
          "x" : 1411,
          "y" : 1117
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1411,
          "y" : 1113
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1411,
          "y" : 1113
        }
      }
    }, {
      "edgeId" : 93623,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93598,
    "reactomeId" : 10571355,
    "displayName" : "p21 RAS:GTP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1482,
      "y" : 1084
    },
    "minX" : 1433,
    "maxX" : 1507,
    "minY" : 1054,
    "maxY" : 1108,
    "prop" : {
      "x" : 1463,
      "y" : 1060,
      "width" : 38,
      "height" : 48
    },
    "textPosition" : {
      "x" : 1464,
      "y" : 1059
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1501,
          "y" : 1060
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1501,
          "y" : 1060
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93594,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1460,
          "y" : 1082
        },
        "to" : {
          "x" : 1433,
          "y" : 1080
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1453,
          "y" : 1085
        },
        "b" : {
          "x" : 1460,
          "y" : 1082
        },
        "c" : {
          "x" : 1453,
          "y" : 1077
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1453,
          "y" : 1077
        }
      }
    } ]
  }, {
    "id" : 93601,
    "reactomeId" : 10591895,
    "displayName" : "rnf41",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2210,
      "y" : 661
    },
    "minX" : 2096,
    "maxX" : 2362,
    "minY" : 271,
    "maxY" : 718,
    "prop" : {
      "x" : 2181,
      "y" : 647,
      "width" : 59,
      "height" : 28
    },
    "textPosition" : {
      "x" : 2190,
      "y" : 650
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2240,
          "y" : 647
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2240,
          "y" : 647
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93645,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2193,
          "y" : 678
        },
        "to" : {
          "x" : 2142,
          "y" : 718
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93645,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2199,
          "y" : 678
        },
        "to" : {
          "x" : 2177,
          "y" : 708
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2174,
          "y" : 711
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2174,
          "y" : 711
        }
      }
    }, {
      "edgeId" : 93600,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2205,
          "y" : 644
        },
        "to" : {
          "x" : 2096,
          "y" : 271
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93603,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2210,
          "y" : 644
        },
        "to" : {
          "x" : 2212,
          "y" : 447
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2206,
          "y" : 637
        },
        "b" : {
          "x" : 2210,
          "y" : 644
        },
        "c" : {
          "x" : 2214,
          "y" : 637
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2214,
          "y" : 637
        }
      }
    }, {
      "edgeId" : 93610,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2243,
          "y" : 659
        },
        "to" : {
          "x" : 2362,
          "y" : 654
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2250,
          "y" : 655
        },
        "b" : {
          "x" : 2243,
          "y" : 659
        },
        "c" : {
          "x" : 2250,
          "y" : 663
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2250,
          "y" : 663
        }
      }
    }, {
      "edgeId" : 93617,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2216,
          "y" : 644
        },
        "to" : {
          "x" : 2356,
          "y" : 343
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93620,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2226,
          "y" : 644
        },
        "to" : {
          "x" : 2335,
          "y" : 555
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2229,
          "y" : 637
        },
        "b" : {
          "x" : 2226,
          "y" : 644
        },
        "c" : {
          "x" : 2234,
          "y" : 643
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2234,
          "y" : 643
        }
      }
    } ]
  }, {
    "id" : 93602,
    "reactomeId" : 10594950,
    "displayName" : "ERBB3:RNF41",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2225,
      "y" : 266
    },
    "minX" : 2199,
    "maxX" : 2257,
    "minY" : 242,
    "maxY" : 370,
    "prop" : {
      "x" : 2199,
      "y" : 248,
      "width" : 52,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2199,
      "y" : 250
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2251,
          "y" : 248
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2251,
          "y" : 248
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93600,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93603,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2222,
          "y" : 288
        },
        "to" : {
          "x" : 2216,
          "y" : 346
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93603,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2232,
          "y" : 288
        },
        "to" : {
          "x" : 2253,
          "y" : 336
        }
      }, {
        "from" : {
          "x" : 2253,
          "y" : 336
        },
        "to" : {
          "x" : 2231,
          "y" : 363
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2229,
          "y" : 366
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2229,
          "y" : 366
        }
      }
    } ]
  }, {
    "id" : 93605,
    "reactomeId" : 10594952,
    "displayName" : "Ub-ERBB3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2268,
      "y" : 426
    },
    "minX" : 2212,
    "maxX" : 2309,
    "minY" : 409,
    "maxY" : 447,
    "prop" : {
      "x" : 2233,
      "y" : 415,
      "width" : 70,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2233,
      "y" : 416
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2303,
          "y" : 415
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2303,
          "y" : 415
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93603,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2238,
          "y" : 440
        },
        "to" : {
          "x" : 2212,
          "y" : 447
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2232,
          "y" : 446
        },
        "b" : {
          "x" : 2238,
          "y" : 440
        },
        "c" : {
          "x" : 2230,
          "y" : 438
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2230,
          "y" : 438
        }
      }
    } ]
  }, {
    "id" : 93604,
    "reactomeId" : 10560375,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2165,
      "y" : 332
    },
    "minX" : 2144,
    "maxX" : 2216,
    "minY" : 322,
    "maxY" : 346,
    "prop" : {
      "x" : 2144,
      "y" : 322,
      "width" : 43,
      "height" : 21
    },
    "textPosition" : {
      "x" : 2153,
      "y" : 322
    },
    "connectors" : [ {
      "edgeId" : 93603,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2193,
          "y" : 337
        },
        "to" : {
          "x" : 2216,
          "y" : 346
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93607,
    "reactomeId" : 10594945,
    "displayName" : "Ub-RNF41",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2248,
      "y" : 718
    },
    "minX" : 2210,
    "maxX" : 2391,
    "minY" : 701,
    "maxY" : 796,
    "prop" : {
      "x" : 2210,
      "y" : 707,
      "width" : 77,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2214,
      "y" : 708
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2287,
          "y" : 707
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2287,
          "y" : 707
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93645,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93606,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2268,
          "y" : 732
        },
        "to" : {
          "x" : 2391,
          "y" : 796
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93609,
    "reactomeId" : 10594973,
    "displayName" : "Ub-RNF41:p-USP8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2365,
      "y" : 715
    },
    "minX" : 2326,
    "maxX" : 2410,
    "minY" : 659,
    "maxY" : 734,
    "prop" : {
      "x" : 2326,
      "y" : 697,
      "width" : 78,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2328,
      "y" : 699
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2404,
          "y" : 697
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2404,
          "y" : 697
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93606,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93610,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93610,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2347,
          "y" : 694
        },
        "to" : {
          "x" : 2336,
          "y" : 684
        }
      }, {
        "from" : {
          "x" : 2336,
          "y" : 684
        },
        "to" : {
          "x" : 2353,
          "y" : 666
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2356,
          "y" : 663
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2356,
          "y" : 663
        }
      }
    } ]
  }, {
    "id" : 93608,
    "reactomeId" : 10594962,
    "displayName" : "phospho-usp8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2464,
      "y" : 664
    },
    "minX" : 2362,
    "maxX" : 2520,
    "minY" : 634,
    "maxY" : 796,
    "prop" : {
      "x" : 2415,
      "y" : 651,
      "width" : 99,
      "height" : 27
    },
    "textPosition" : {
      "x" : 2415,
      "y" : 654
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2514,
          "y" : 651
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2514,
          "y" : 651
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93606,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2463,
          "y" : 681
        },
        "to" : {
          "x" : 2459,
          "y" : 777
        }
      }, {
        "from" : {
          "x" : 2459,
          "y" : 777
        },
        "to" : {
          "x" : 2391,
          "y" : 796
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93610,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2412,
          "y" : 659
        },
        "to" : {
          "x" : 2362,
          "y" : 654
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2405,
          "y" : 662
        },
        "b" : {
          "x" : 2412,
          "y" : 659
        },
        "c" : {
          "x" : 2406,
          "y" : 654
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2406,
          "y" : 654
        }
      }
    }, {
      "edgeId" : 93612,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2489,
          "y" : 648
        },
        "to" : {
          "x" : 2520,
          "y" : 634
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2494,
          "y" : 642
        },
        "b" : {
          "x" : 2489,
          "y" : 648
        },
        "c" : {
          "x" : 2497,
          "y" : 649
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2497,
          "y" : 649
        }
      }
    } ]
  }, {
    "id" : 93611,
    "reactomeId" : 10560375,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2363,
      "y" : 598
    },
    "minX" : 2343,
    "maxX" : 2384,
    "minY" : 588,
    "maxY" : 654,
    "prop" : {
      "x" : 2343,
      "y" : 588,
      "width" : 41,
      "height" : 20
    },
    "textPosition" : {
      "x" : 2351,
      "y" : 588
    },
    "connectors" : [ {
      "edgeId" : 93610,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2362,
          "y" : 614
        },
        "to" : {
          "x" : 2362,
          "y" : 654
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2366,
          "y" : 621
        },
        "b" : {
          "x" : 2362,
          "y" : 614
        },
        "c" : {
          "x" : 2358,
          "y" : 621
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2358,
          "y" : 621
        }
      }
    } ]
  }, {
    "id" : 93613,
    "reactomeId" : 10594959,
    "displayName" : "usp8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2663,
      "y" : 648
    },
    "minX" : 2592,
    "maxX" : 2699,
    "minY" : 631,
    "maxY" : 660,
    "prop" : {
      "x" : 2633,
      "y" : 637,
      "width" : 60,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2643,
      "y" : 638
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2693,
          "y" : 637
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2693,
          "y" : 637
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93612,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2630,
          "y" : 642
        },
        "to" : {
          "x" : 2592,
          "y" : 634
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93615,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2503,
      "y" : 594
    },
    "minX" : 2482,
    "maxX" : 2526,
    "minY" : 579,
    "maxY" : 634,
    "prop" : {
      "x" : 2482,
      "y" : 580,
      "width" : 43,
      "height" : 29
    },
    "textPosition" : {
      "x" : 2487,
      "y" : 584
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2520,
          "y" : 585
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2520,
          "y" : 585
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93612,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2509,
          "y" : 612
        },
        "to" : {
          "x" : 2520,
          "y" : 634
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2516,
          "y" : 616
        },
        "b" : {
          "x" : 2509,
          "y" : 612
        },
        "c" : {
          "x" : 2509,
          "y" : 620
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2509,
          "y" : 620
        }
      }
    } ]
  }, {
    "id" : 93614,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2639,
      "y" : 601
    },
    "minX" : 2592,
    "maxX" : 2662,
    "minY" : 586,
    "maxY" : 634,
    "prop" : {
      "x" : 2618,
      "y" : 587,
      "width" : 43,
      "height" : 29
    },
    "textPosition" : {
      "x" : 2624,
      "y" : 591
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2656,
          "y" : 592
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2656,
          "y" : 592
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93612,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2615,
          "y" : 616
        },
        "to" : {
          "x" : 2592,
          "y" : 634
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93616,
    "reactomeId" : 10574409,
    "displayName" : "p-T,p-S-AKT",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2552,
      "y" : 717
    },
    "minX" : 2522,
    "maxX" : 2582,
    "minY" : 643,
    "maxY" : 734,
    "prop" : {
      "x" : 2522,
      "y" : 701,
      "width" : 60,
      "height" : 33
    },
    "textPosition" : {
      "x" : 2524,
      "y" : 700
    },
    "connectors" : [ {
      "edgeId" : 93612,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2552,
          "y" : 695
        },
        "to" : {
          "x" : 2554,
          "y" : 651
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2554,
          "y" : 647
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2554,
          "y" : 647
        }
      }
    } ]
  }, {
    "id" : 93619,
    "reactomeId" : 10594966,
    "displayName" : "NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2397,
      "y" : 436
    },
    "minX" : 2341,
    "maxX" : 2459,
    "minY" : 406,
    "maxY" : 512,
    "prop" : {
      "x" : 2341,
      "y" : 412,
      "width" : 112,
      "height" : 48
    },
    "textPosition" : {
      "x" : 2343,
      "y" : 411
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2453,
          "y" : 412
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2453,
          "y" : 412
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93617,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93620,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2377,
          "y" : 463
        },
        "to" : {
          "x" : 2363,
          "y" : 477
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93620,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2398,
          "y" : 463
        },
        "to" : {
          "x" : 2401,
          "y" : 494
        }
      }, {
        "from" : {
          "x" : 2401,
          "y" : 494
        },
        "to" : {
          "x" : 2375,
          "y" : 506
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2371,
          "y" : 508
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2371,
          "y" : 508
        }
      }
    } ]
  }, {
    "id" : 93618,
    "reactomeId" : 10594338,
    "displayName" : "Phosphorylated ERBB2:ERBB3 heterodimers",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2510,
      "y" : 288
    },
    "minX" : 2356,
    "maxX" : 2817,
    "minY" : 263,
    "maxY" : 480,
    "prop" : {
      "x" : 2455,
      "y" : 263,
      "width" : 111,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2455,
      "y" : 263
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 93661,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2549,
          "y" : 319
        },
        "to" : {
          "x" : 2817,
          "y" : 480
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93617,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2449,
          "y" : 307
        },
        "to" : {
          "x" : 2356,
          "y" : 343
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93621,
    "reactomeId" : 10560375,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2322,
      "y" : 486
    },
    "minX" : 2305,
    "maxX" : 2363,
    "minY" : 476,
    "maxY" : 496,
    "prop" : {
      "x" : 2305,
      "y" : 476,
      "width" : 34,
      "height" : 20
    },
    "textPosition" : {
      "x" : 2309,
      "y" : 476
    },
    "connectors" : [ {
      "edgeId" : 93620,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2345,
          "y" : 482
        },
        "to" : {
          "x" : 2363,
          "y" : 477
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93622,
    "reactomeId" : 10594968,
    "displayName" : "NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2459,
      "y" : 537
    },
    "minX" : 2335,
    "maxX" : 2517,
    "minY" : 508,
    "maxY" : 561,
    "prop" : {
      "x" : 2408,
      "y" : 514,
      "width" : 103,
      "height" : 47
    },
    "textPosition" : {
      "x" : 2414,
      "y" : 512
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2511,
          "y" : 514
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2511,
          "y" : 514
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93620,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2405,
          "y" : 544
        },
        "to" : {
          "x" : 2335,
          "y" : 555
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2399,
          "y" : 549
        },
        "b" : {
          "x" : 2405,
          "y" : 544
        },
        "c" : {
          "x" : 2398,
          "y" : 541
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2398,
          "y" : 541
        }
      }
    } ]
  }, {
    "id" : 93625,
    "reactomeId" : 10564183,
    "displayName" : "GRB2-1:SOS1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1667,
      "y" : 879
    },
    "minX" : 1635,
    "maxX" : 2185,
    "minY" : 856,
    "maxY" : 931,
    "prop" : {
      "x" : 1635,
      "y" : 862,
      "width" : 64,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1638,
      "y" : 862
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1699,
          "y" : 862
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1699,
          "y" : 862
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93623,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1702,
          "y" : 882
        },
        "to" : {
          "x" : 2185,
          "y" : 931
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93624,
    "reactomeId" : 10594926,
    "displayName" : "Phosphorylated ERBB2:ERBB4 heterodimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2261,
      "y" : 1054
    },
    "minX" : 2185,
    "maxX" : 2320,
    "minY" : 931,
    "maxY" : 1079,
    "prop" : {
      "x" : 2202,
      "y" : 1029,
      "width" : 118,
      "height" : 50
    },
    "textPosition" : {
      "x" : 2206,
      "y" : 1029
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 93623,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2245,
          "y" : 1023
        },
        "to" : {
          "x" : 2185,
          "y" : 931
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93627,
    "reactomeId" : 10598461,
    "displayName" : "ERBB2:ERBIN:HSP90:CDC37",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 719,
      "y" : 370
    },
    "minX" : 584,
    "maxX" : 814,
    "minY" : 342,
    "maxY" : 453,
    "prop" : {
      "x" : 631,
      "y" : 354,
      "width" : 177,
      "height" : 32
    },
    "textPosition" : {
      "x" : 651,
      "y" : 351
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "fgColor" : {
      "r" : 0,
      "g" : 0,
      "b" : 0
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 808,
          "y" : 354
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 808,
          "y" : 354
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93672,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 641,
          "y" : 351
        },
        "to" : {
          "x" : 584,
          "y" : 342
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93626,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 712,
          "y" : 389
        },
        "to" : {
          "x" : 684,
          "y" : 453
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93629,
    "reactomeId" : 10598465,
    "displayName" : "Ub-ERBB2:ERBIN:HSP90:CDC37",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 662,
      "y" : 684
    },
    "minX" : 598,
    "maxX" : 733,
    "minY" : 660,
    "maxY" : 702,
    "prop" : {
      "x" : 598,
      "y" : 666,
      "width" : 129,
      "height" : 36
    },
    "textPosition" : {
      "x" : 606,
      "y" : 667
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 727,
          "y" : 666
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 727,
          "y" : 666
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93626,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93628,
    "reactomeId" : 10560375,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 762,
      "y" : 509
    },
    "minX" : 684,
    "maxX" : 783,
    "minY" : 453,
    "maxY" : 518,
    "prop" : {
      "x" : 741,
      "y" : 500,
      "width" : 42,
      "height" : 18
    },
    "textPosition" : {
      "x" : 749,
      "y" : 499
    },
    "connectors" : [ {
      "edgeId" : 93626,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 749,
          "y" : 494
        },
        "to" : {
          "x" : 684,
          "y" : 453
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93630,
    "reactomeId" : 10591829,
    "displayName" : "cul5a",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 890,
      "y" : 593
    },
    "minX" : 689,
    "maxX" : 917,
    "minY" : 525,
    "maxY" : 604,
    "prop" : {
      "x" : 870,
      "y" : 582,
      "width" : 41,
      "height" : 22
    },
    "textPosition" : {
      "x" : 873,
      "y" : 576
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 911,
          "y" : 582
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 911,
          "y" : 582
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93626,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 867,
          "y" : 586
        },
        "to" : {
          "x" : 697,
          "y" : 530
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 693,
          "y" : 529
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 693,
          "y" : 529
        }
      }
    } ]
  }, {
    "id" : 93633,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1174,
      "y" : 415
    },
    "minX" : 1146,
    "maxX" : 1195,
    "minY" : 354,
    "maxY" : 443,
    "prop" : {
      "x" : 1155,
      "y" : 401,
      "width" : 39,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1159,
      "y" : 405
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1189,
          "y" : 406
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1189,
          "y" : 406
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93641,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1178,
          "y" : 398
        },
        "to" : {
          "x" : 1194,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 43,
        "shape" : {
          "a" : {
            "x" : 1180,
            "y" : 370
          },
          "b" : {
            "x" : 1192,
            "y" : 382
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1186,
            "y" : 376
          }
        }
      }
    }, {
      "edgeId" : 93631,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1159,
          "y" : 433
        },
        "to" : {
          "x" : 1146,
          "y" : 443
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93632,
    "reactomeId" : 10598553,
    "displayName" : "ERBB2 heterodimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1089,
      "y" : 379
    },
    "minX" : 1043,
    "maxX" : 1214,
    "minY" : 332,
    "maxY" : 443,
    "prop" : {
      "x" : 1043,
      "y" : 361,
      "width" : 93,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1043,
      "y" : 361
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 93641,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1142,
          "y" : 367
        },
        "to" : {
          "x" : 1194,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93641,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1128,
          "y" : 355
        },
        "to" : {
          "x" : 1191,
          "y" : 332
        }
      }, {
        "from" : {
          "x" : 1191,
          "y" : 332
        },
        "to" : {
          "x" : 1206,
          "y" : 341
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1210,
          "y" : 343
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1210,
          "y" : 343
        }
      }
    }, {
      "edgeId" : 93631,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1105,
          "y" : 403
        },
        "to" : {
          "x" : 1146,
          "y" : 443
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93635,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1267,
      "y" : 415
    },
    "minX" : 1234,
    "maxX" : 1289,
    "minY" : 350,
    "maxY" : 445,
    "prop" : {
      "x" : 1246,
      "y" : 401,
      "width" : 42,
      "height" : 28
    },
    "textPosition" : {
      "x" : 1250,
      "y" : 404
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1283,
          "y" : 406
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1283,
          "y" : 406
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93641,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1266,
          "y" : 398
        },
        "to" : {
          "x" : 1266,
          "y" : 350
        }
      } ],
      "stoichiometry" : {
        "value" : 43,
        "shape" : {
          "a" : {
            "x" : 1260,
            "y" : 368
          },
          "b" : {
            "x" : 1272,
            "y" : 380
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1266,
            "y" : 374
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1262,
          "y" : 391
        },
        "b" : {
          "x" : 1266,
          "y" : 398
        },
        "c" : {
          "x" : 1270,
          "y" : 391
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1270,
          "y" : 391
        }
      }
    }, {
      "edgeId" : 93631,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1251,
          "y" : 432
        },
        "to" : {
          "x" : 1234,
          "y" : 445
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1248,
          "y" : 439
        },
        "b" : {
          "x" : 1251,
          "y" : 432
        },
        "c" : {
          "x" : 1243,
          "y" : 433
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1243,
          "y" : 433
        }
      }
    } ]
  }, {
    "id" : 93634,
    "reactomeId" : 10598540,
    "displayName" : "p-Y877-ERBB2 heterodimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1342,
      "y" : 451
    },
    "minX" : 1234,
    "maxX" : 1393,
    "minY" : 433,
    "maxY" : 518,
    "prop" : {
      "x" : 1291,
      "y" : 433,
      "width" : 102,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1292,
      "y" : 433
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 93637,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1344,
          "y" : 475
        },
        "to" : {
          "x" : 1348,
          "y" : 502
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93637,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1354,
          "y" : 475
        },
        "to" : {
          "x" : 1377,
          "y" : 502
        }
      }, {
        "from" : {
          "x" : 1377,
          "y" : 502
        },
        "to" : {
          "x" : 1357,
          "y" : 513
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1354,
          "y" : 514
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1354,
          "y" : 514
        }
      }
    }, {
      "edgeId" : 93631,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1285,
          "y" : 448
        },
        "to" : {
          "x" : 1234,
          "y" : 445
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1278,
          "y" : 452
        },
        "b" : {
          "x" : 1285,
          "y" : 448
        },
        "c" : {
          "x" : 1278,
          "y" : 444
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1278,
          "y" : 444
        }
      }
    } ]
  }, {
    "id" : 93636,
    "reactomeId" : 10598575,
    "displayName" : "p-Y419/420/426-N-myristoyl-SRC/FYN/YES1",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1189,
      "y" : 527
    },
    "minX" : 1129,
    "maxX" : 1250,
    "minY" : 458,
    "maxY" : 550,
    "prop" : {
      "x" : 1129,
      "y" : 504,
      "width" : 121,
      "height" : 46
    },
    "textPosition" : {
      "x" : 1134,
      "y" : 503
    },
    "connectors" : [ {
      "edgeId" : 93631,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1189,
          "y" : 498
        },
        "to" : {
          "x" : 1190,
          "y" : 466
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1191,
          "y" : 462
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1191,
          "y" : 462
        }
      }
    } ]
  }, {
    "id" : 93639,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1279,
      "y" : 585
    },
    "minX" : 1256,
    "maxX" : 1339,
    "minY" : 569,
    "maxY" : 600,
    "prop" : {
      "x" : 1256,
      "y" : 570,
      "width" : 46,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1262,
      "y" : 574
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1297,
          "y" : 575
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1297,
          "y" : 575
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93637,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1305,
          "y" : 579
        },
        "to" : {
          "x" : 1339,
          "y" : 571
        }
      } ],
      "stoichiometry" : {
        "value" : 43,
        "shape" : {
          "a" : {
            "x" : 1316,
            "y" : 569
          },
          "b" : {
            "x" : 1328,
            "y" : 581
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1322,
            "y" : 575
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1311,
          "y" : 574
        },
        "b" : {
          "x" : 1305,
          "y" : 579
        },
        "c" : {
          "x" : 1313,
          "y" : 581
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1313,
          "y" : 581
        }
      }
    } ]
  }, {
    "id" : 93638,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1293,
      "y" : 497
    },
    "minX" : 1273,
    "maxX" : 1348,
    "minY" : 481,
    "maxY" : 512,
    "prop" : {
      "x" : 1273,
      "y" : 482,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1277,
      "y" : 486
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1308,
          "y" : 487
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1308,
          "y" : 487
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93637,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1316,
          "y" : 498
        },
        "to" : {
          "x" : 1348,
          "y" : 502
        }
      } ],
      "stoichiometry" : {
        "value" : 43,
        "shape" : {
          "a" : {
            "x" : 1326,
            "y" : 494
          },
          "b" : {
            "x" : 1338,
            "y" : 506
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1332,
            "y" : 500
          }
        }
      }
    } ]
  }, {
    "id" : 93640,
    "reactomeId" : 10594392,
    "displayName" : "Autophosphorylated p-Y877-ERBB2 heterodimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1473,
      "y" : 446
    },
    "minX" : 1339,
    "maxX" : 1535,
    "minY" : 422,
    "maxY" : 575,
    "prop" : {
      "x" : 1411,
      "y" : 422,
      "width" : 124,
      "height" : 48
    },
    "textPosition" : {
      "x" : 1413,
      "y" : 422
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 93637,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1453,
          "y" : 476
        },
        "to" : {
          "x" : 1368,
          "y" : 575
        }
      }, {
        "from" : {
          "x" : 1368,
          "y" : 575
        },
        "to" : {
          "x" : 1339,
          "y" : 571
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1452,
          "y" : 484
        },
        "b" : {
          "x" : 1453,
          "y" : 476
        },
        "c" : {
          "x" : 1445,
          "y" : 479
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1445,
          "y" : 479
        }
      }
    } ]
  }, {
    "id" : 93643,
    "reactomeId" : 10598558,
    "displayName" : "ERBB2:trastuzumab:ERBIN:HSP90:CDC37",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 769,
      "y" : 208
    },
    "minX" : 720,
    "maxX" : 1222,
    "minY" : 170,
    "maxY" : 341,
    "prop" : {
      "x" : 720,
      "y" : 176,
      "width" : 99,
      "height" : 64
    },
    "textPosition" : {
      "x" : 723,
      "y" : 177
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 819,
          "y" : 176
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 819,
          "y" : 176
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93641,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 772,
          "y" : 243
        },
        "to" : {
          "x" : 780,
          "y" : 307
        }
      }, {
        "from" : {
          "x" : 780,
          "y" : 307
        },
        "to" : {
          "x" : 1206,
          "y" : 300
        }
      }, {
        "from" : {
          "x" : 1206,
          "y" : 300
        },
        "to" : {
          "x" : 1218,
          "y" : 340
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1214,
          "y" : 341
        },
        "b" : {
          "x" : 1222,
          "y" : 339
        },
        "c" : {
          "x" : 1218,
          "y" : 340
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1218,
          "y" : 340
        }
      }
    } ]
  }, {
    "id" : 93642,
    "reactomeId" : 10594382,
    "displayName" : "p-6Y-ERBB2 heterodimers",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1374,
      "y" : 373
    },
    "minX" : 1266,
    "maxX" : 1430,
    "minY" : 350,
    "maxY" : 393,
    "prop" : {
      "x" : 1318,
      "y" : 354,
      "width" : 112,
      "height" : 39
    },
    "textPosition" : {
      "x" : 1328,
      "y" : 356
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 93641,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1312,
          "y" : 361
        },
        "to" : {
          "x" : 1266,
          "y" : 350
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1304,
          "y" : 363
        },
        "b" : {
          "x" : 1312,
          "y" : 361
        },
        "c" : {
          "x" : 1306,
          "y" : 355
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1306,
          "y" : 355
        }
      }
    } ]
  }, {
    "id" : 93644,
    "reactomeId" : 10598562,
    "displayName" : "ERBB2:TKIs:ERBIN:HSP90:CDC37",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 556,
      "y" : 177
    },
    "minX" : 498,
    "maxX" : 1236,
    "minY" : 153,
    "maxY" : 343,
    "prop" : {
      "x" : 498,
      "y" : 159,
      "width" : 117,
      "height" : 36
    },
    "textPosition" : {
      "x" : 510,
      "y" : 146
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 615,
          "y" : 159
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 615,
          "y" : 159
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93641,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 562,
          "y" : 198
        },
        "to" : {
          "x" : 611,
          "y" : 329
        }
      }, {
        "from" : {
          "x" : 611,
          "y" : 329
        },
        "to" : {
          "x" : 1236,
          "y" : 317
        }
      }, {
        "from" : {
          "x" : 1236,
          "y" : 317
        },
        "to" : {
          "x" : 1224,
          "y" : 341
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1220,
          "y" : 339
        },
        "b" : {
          "x" : 1228,
          "y" : 343
        },
        "c" : {
          "x" : 1224,
          "y" : 341
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1224,
          "y" : 341
        }
      }
    }, {
      "edgeId" : 93672,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93646,
    "reactomeId" : 10560375,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2114,
      "y" : 756
    },
    "minX" : 2095,
    "maxX" : 2142,
    "minY" : 718,
    "maxY" : 766,
    "prop" : {
      "x" : 2095,
      "y" : 746,
      "width" : 38,
      "height" : 20
    },
    "textPosition" : {
      "x" : 2101,
      "y" : 746
    },
    "connectors" : [ {
      "edgeId" : 93645,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2121,
          "y" : 740
        },
        "to" : {
          "x" : 2142,
          "y" : 718
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93649,
    "reactomeId" : 10598522,
    "displayName" : "si:ch73-206d17.1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1874,
      "y" : 592
    },
    "minX" : 1831,
    "maxX" : 1902,
    "minY" : 487,
    "maxY" : 603,
    "prop" : {
      "x" : 1853,
      "y" : 581,
      "width" : 43,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1853,
      "y" : 561
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1896,
          "y" : 581
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1896,
          "y" : 581
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93647,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1869,
          "y" : 578
        },
        "to" : {
          "x" : 1831,
          "y" : 487
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93648,
    "reactomeId" : 10594394,
    "displayName" : "p-ERBB2 heterodimers",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1643,
      "y" : 296
    },
    "minX" : 1524,
    "maxX" : 2030,
    "minY" : 275,
    "maxY" : 825,
    "prop" : {
      "x" : 1599,
      "y" : 275,
      "width" : 88,
      "height" : 43
    },
    "textPosition" : {
      "x" : 1600,
      "y" : 272
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ {
      "edgeId" : 93647,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1664,
          "y" : 324
        },
        "to" : {
          "x" : 1831,
          "y" : 487
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93651,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1670,
          "y" : 324
        },
        "to" : {
          "x" : 1872,
          "y" : 473
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93654,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1656,
          "y" : 324
        },
        "to" : {
          "x" : 1885,
          "y" : 671
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93657,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1653,
          "y" : 324
        },
        "to" : {
          "x" : 1903,
          "y" : 825
        }
      }, {
        "from" : {
          "x" : 1903,
          "y" : 825
        },
        "to" : {
          "x" : 2030,
          "y" : 721
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1660,
          "y" : 328
        },
        "b" : {
          "x" : 1653,
          "y" : 324
        },
        "c" : {
          "x" : 1653,
          "y" : 332
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1653,
          "y" : 332
        }
      }
    }, {
      "edgeId" : 93662,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1631,
          "y" : 324
        },
        "to" : {
          "x" : 1524,
          "y" : 510
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93650,
    "reactomeId" : 10598524,
    "displayName" : "p-ERBB2 heterodimers:MATK",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1854,
      "y" : 326
    },
    "minX" : 1808,
    "maxX" : 1907,
    "minY" : 294,
    "maxY" : 352,
    "prop" : {
      "x" : 1808,
      "y" : 300,
      "width" : 93,
      "height" : 52
    },
    "textPosition" : {
      "x" : 1808,
      "y" : 303
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1901,
          "y" : 300
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1901,
          "y" : 300
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93647,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93653,
    "reactomeId" : 10621384,
    "displayName" : "p-ERBB2 heterodimers:MEMO1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1928,
      "y" : 384
    },
    "minX" : 1881,
    "maxX" : 1981,
    "minY" : 354,
    "maxY" : 408,
    "prop" : {
      "x" : 1881,
      "y" : 360,
      "width" : 94,
      "height" : 48
    },
    "textPosition" : {
      "x" : 1882,
      "y" : 359
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1975,
          "y" : 360
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1975,
          "y" : 360
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93651,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93652,
    "reactomeId" : 10621382,
    "displayName" : "memo1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1926,
      "y" : 616
    },
    "minX" : 1872,
    "maxX" : 1959,
    "minY" : 473,
    "maxY" : 627,
    "prop" : {
      "x" : 1899,
      "y" : 605,
      "width" : 54,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1899,
      "y" : 605
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1953,
          "y" : 605
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1953,
          "y" : 605
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93651,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1921,
          "y" : 602
        },
        "to" : {
          "x" : 1872,
          "y" : 473
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93655,
    "reactomeId" : 10629144,
    "displayName" : "PTK6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1901,
      "y" : 723
    },
    "minX" : 1882,
    "maxX" : 1927,
    "minY" : 671,
    "maxY" : 734,
    "prop" : {
      "x" : 1882,
      "y" : 712,
      "width" : 39,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1882,
      "y" : 712
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1921,
          "y" : 712
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1921,
          "y" : 712
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93654,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1897,
          "y" : 709
        },
        "to" : {
          "x" : 1885,
          "y" : 671
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93656,
    "reactomeId" : 10629146,
    "displayName" : "p-ERBB2 heterodimers:PTK6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2035,
      "y" : 540
    },
    "minX" : 1990,
    "maxX" : 2086,
    "minY" : 511,
    "maxY" : 672,
    "prop" : {
      "x" : 1990,
      "y" : 517,
      "width" : 90,
      "height" : 47
    },
    "textPosition" : {
      "x" : 1992,
      "y" : 515
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2080,
          "y" : 517
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2080,
          "y" : 517
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93654,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93657,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2033,
          "y" : 567
        },
        "to" : {
          "x" : 2031,
          "y" : 625
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93657,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2027,
          "y" : 567
        },
        "to" : {
          "x" : 2008,
          "y" : 629
        }
      }, {
        "from" : {
          "x" : 2008,
          "y" : 629
        },
        "to" : {
          "x" : 2025,
          "y" : 665
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2027,
          "y" : 668
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2027,
          "y" : 668
        }
      }
    } ]
  }, {
    "id" : 93659,
    "reactomeId" : 10629151,
    "displayName" : "phospho-p-Y342-PTK6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2043,
      "y" : 796
    },
    "minX" : 1994,
    "maxX" : 2098,
    "minY" : 721,
    "maxY" : 810,
    "prop" : {
      "x" : 1994,
      "y" : 783,
      "width" : 98,
      "height" : 27
    },
    "textPosition" : {
      "x" : 2003,
      "y" : 779
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2092,
          "y" : 783
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2092,
          "y" : 783
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93657,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2040,
          "y" : 780
        },
        "to" : {
          "x" : 2030,
          "y" : 721
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2035,
          "y" : 774
        },
        "b" : {
          "x" : 2040,
          "y" : 780
        },
        "c" : {
          "x" : 2043,
          "y" : 773
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2043,
          "y" : 773
        }
      }
    } ]
  }, {
    "id" : 93658,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2070,
      "y" : 609
    },
    "minX" : 2031,
    "maxX" : 2089,
    "minY" : 597,
    "maxY" : 625,
    "prop" : {
      "x" : 2052,
      "y" : 598,
      "width" : 36,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2054,
      "y" : 599
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2083,
          "y" : 603
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2083,
          "y" : 603
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93657,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2049,
          "y" : 616
        },
        "to" : {
          "x" : 2031,
          "y" : 625
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93660,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2067,
      "y" : 733
    },
    "minX" : 2030,
    "maxX" : 2087,
    "minY" : 720,
    "maxY" : 745,
    "prop" : {
      "x" : 2048,
      "y" : 721,
      "width" : 38,
      "height" : 24
    },
    "textPosition" : {
      "x" : 2050,
      "y" : 722
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2081,
          "y" : 726
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2081,
          "y" : 726
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93657,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2045,
          "y" : 726
        },
        "to" : {
          "x" : 2030,
          "y" : 721
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2037,
          "y" : 728
        },
        "b" : {
          "x" : 2045,
          "y" : 726
        },
        "c" : {
          "x" : 2040,
          "y" : 720
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2040,
          "y" : 720
        }
      }
    } ]
  }, {
    "id" : 93663,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1411,
      "y" : 583
    },
    "minX" : 1390,
    "maxX" : 1524,
    "minY" : 499,
    "maxY" : 598,
    "prop" : {
      "x" : 1390,
      "y" : 568,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1394,
      "y" : 572
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1428,
          "y" : 573
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1428,
          "y" : 573
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93662,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1425,
          "y" : 565
        },
        "to" : {
          "x" : 1493,
          "y" : 499
        }
      }, {
        "from" : {
          "x" : 1493,
          "y" : 499
        },
        "to" : {
          "x" : 1524,
          "y" : 510
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 93665,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1455,
      "y" : 670
    },
    "minX" : 1439,
    "maxX" : 1498,
    "minY" : 602,
    "maxY" : 682,
    "prop" : {
      "x" : 1439,
      "y" : 658,
      "width" : 33,
      "height" : 24
    },
    "textPosition" : {
      "x" : 1446,
      "y" : 659
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1467,
          "y" : 663
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1467,
          "y" : 663
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93662,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1462,
          "y" : 655
        },
        "to" : {
          "x" : 1498,
          "y" : 602
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1463,
          "y" : 647
        },
        "b" : {
          "x" : 1462,
          "y" : 655
        },
        "c" : {
          "x" : 1469,
          "y" : 652
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1469,
          "y" : 652
        }
      }
    } ]
  }, {
    "id" : 93664,
    "reactomeId" : 10631118,
    "displayName" : "Heterodimers of p-ERBB2 dephosphorylated at Y1248",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1613,
      "y" : 551
    },
    "minX" : 1498,
    "maxX" : 1671,
    "minY" : 521,
    "maxY" : 602,
    "prop" : {
      "x" : 1556,
      "y" : 521,
      "width" : 115,
      "height" : 61
    },
    "textPosition" : {
      "x" : 1556,
      "y" : 520
    },
    "connectors" : [ {
      "edgeId" : 93662,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1550,
          "y" : 576
        },
        "to" : {
          "x" : 1498,
          "y" : 602
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1546,
          "y" : 583
        },
        "b" : {
          "x" : 1550,
          "y" : 576
        },
        "c" : {
          "x" : 1542,
          "y" : 576
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1542,
          "y" : 576
        }
      }
    } ]
  }, {
    "id" : 93666,
    "reactomeId" : 10631122,
    "displayName" : "ptpn12",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1400,
      "y" : 638
    },
    "minX" : 1372,
    "maxX" : 1498,
    "minY" : 566,
    "maxY" : 649,
    "prop" : {
      "x" : 1372,
      "y" : 627,
      "width" : 56,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1373,
      "y" : 627
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1428,
          "y" : 627
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1428,
          "y" : 627
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93662,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1415,
          "y" : 624
        },
        "to" : {
          "x" : 1491,
          "y" : 572
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1494,
          "y" : 570
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1494,
          "y" : 570
        }
      }
    } ]
  }, {
    "id" : 93669,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 967,
      "y" : 1022
    },
    "minX" : 946,
    "maxX" : 990,
    "minY" : 1008,
    "maxY" : 1131,
    "prop" : {
      "x" : 946,
      "y" : 1009,
      "width" : 43,
      "height" : 27
    },
    "textPosition" : {
      "x" : 950,
      "y" : 1012
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 984,
          "y" : 1014
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 984,
          "y" : 1014
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93667,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 967,
          "y" : 1039
        },
        "to" : {
          "x" : 969,
          "y" : 1131
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 962,
            "y" : 1079
          },
          "b" : {
            "x" : 974,
            "y" : 1091
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 968,
            "y" : 1085
          }
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 93668,
    "reactomeId" : 10631360,
    "displayName" : "Phosphorylated ERBB2:EGFR heterodimers:PTPN18",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1014,
      "y" : 1186
    },
    "minX" : 919,
    "maxX" : 1077,
    "minY" : 1131,
    "maxY" : 1217,
    "prop" : {
      "x" : 957,
      "y" : 1155,
      "width" : 114,
      "height" : 62
    },
    "textPosition" : {
      "x" : 959,
      "y" : 1154
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1071,
          "y" : 1155
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1071,
          "y" : 1155
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93667,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 988,
          "y" : 1152
        },
        "to" : {
          "x" : 969,
          "y" : 1131
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 93667,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 954,
          "y" : 1187
        },
        "to" : {
          "x" : 919,
          "y" : 1189
        }
      }, {
        "from" : {
          "x" : 919,
          "y" : 1189
        },
        "to" : {
          "x" : 925,
          "y" : 1149
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 925,
          "y" : 1145
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 925,
          "y" : 1145
        }
      }
    } ]
  }, {
    "id" : 93671,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 907,
      "y" : 1021
    },
    "minX" : 891,
    "maxX" : 925,
    "minY" : 1008,
    "maxY" : 1120,
    "prop" : {
      "x" : 891,
      "y" : 1009,
      "width" : 33,
      "height" : 24
    },
    "textPosition" : {
      "x" : 898,
      "y" : 1010
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 919,
          "y" : 1014
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 919,
          "y" : 1014
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93667,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 906,
          "y" : 1036
        },
        "to" : {
          "x" : 906,
          "y" : 1120
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 900,
            "y" : 1072
          },
          "b" : {
            "x" : 912,
            "y" : 1084
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 906,
            "y" : 1078
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 910,
          "y" : 1043
        },
        "b" : {
          "x" : 906,
          "y" : 1036
        },
        "c" : {
          "x" : 902,
          "y" : 1043
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 902,
          "y" : 1043
        }
      }
    } ]
  }, {
    "id" : 93670,
    "reactomeId" : 10631364,
    "displayName" : "Phosphorylated ERBB2(dephosphorylated at Y1196,Y1112 and Y1248):EGFR heterodimers:PTPN18",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 789,
      "y" : 1174
    },
    "minX" : 717,
    "maxX" : 906,
    "minY" : 1120,
    "maxY" : 1213,
    "prop" : {
      "x" : 717,
      "y" : 1135,
      "width" : 145,
      "height" : 78
    },
    "textPosition" : {
      "x" : 716,
      "y" : 1122
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 862,
          "y" : 1135
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 862,
          "y" : 1135
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 93667,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 865,
          "y" : 1140
        },
        "to" : {
          "x" : 906,
          "y" : 1120
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 869,
          "y" : 1133
        },
        "b" : {
          "x" : 865,
          "y" : 1140
        },
        "c" : {
          "x" : 873,
          "y" : 1141
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 873,
          "y" : 1141
        }
      }
    } ]
  }, {
    "id" : 93673,
    "reactomeId" : 9652360,
    "displayName" : "lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 558,
      "y" : 468
    },
    "minX" : 486,
    "maxX" : 630,
    "minY" : 342,
    "maxY" : 507,
    "prop" : {
      "x" : 486,
      "y" : 430,
      "width" : 144,
      "height" : 77
    },
    "textPosition" : {
      "x" : 488,
      "y" : 430
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 93672,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 565,
          "y" : 424
        },
        "to" : {
          "x" : 584,
          "y" : 342
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 93683,
    "reactomeId" : 10648028,
    "displayName" : "PIP3 activates AKT signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 2578,
      "y" : 944
    },
    "minX" : 2509,
    "maxX" : 2647,
    "minY" : 909,
    "maxY" : 979,
    "prop" : {
      "x" : 2509,
      "y" : 909,
      "width" : 138,
      "height" : 70
    },
    "textPosition" : {
      "x" : 2511,
      "y" : 922
    },
    "connectors" : [ ]
  }, {
    "id" : 93682,
    "reactomeId" : 10576084,
    "displayName" : "phospho-plcg1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 800,
      "y" : 795
    },
    "minX" : 749,
    "maxX" : 858,
    "minY" : 774,
    "maxY" : 810,
    "prop" : {
      "x" : 749,
      "y" : 780,
      "width" : 103,
      "height" : 30
    },
    "textPosition" : {
      "x" : 750,
      "y" : 784
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 852,
          "y" : 780
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 852,
          "y" : 780
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 93687,
    "reactomeId" : 10598580,
    "displayName" : "Ligand-Activated EGFR/ERBB3/ERBB4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 901,
      "y" : 254
    },
    "minX" : 837,
    "maxX" : 966,
    "minY" : 236,
    "maxY" : 272,
    "prop" : {
      "x" : 837,
      "y" : 236,
      "width" : 129,
      "height" : 36
    },
    "textPosition" : {
      "x" : 837,
      "y" : 236
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ ]
  }, {
    "id" : 93689,
    "reactomeId" : 10616061,
    "displayName" : "Ghost homologue of Phosphorylated ERBB2:EGFR heterodimers",
    "schemaClass" : "GenomeEncodedEntity",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1094,
      "y" : 1066
    },
    "minX" : 1042,
    "maxX" : 1146,
    "minY" : 1034,
    "maxY" : 1098,
    "prop" : {
      "x" : 1042,
      "y" : 1034,
      "width" : 104,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1044,
      "y" : 1028
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "connectors" : [ ]
  }, {
    "id" : 93691,
    "reactomeId" : 10650054,
    "displayName" : "RAF/MAP kinase cascade",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1497,
      "y" : 940
    },
    "minX" : 1432,
    "maxX" : 1563,
    "minY" : 909,
    "maxY" : 971,
    "prop" : {
      "x" : 1432,
      "y" : 909,
      "width" : 131,
      "height" : 62
    },
    "textPosition" : {
      "x" : 1438,
      "y" : 918
    },
    "connectors" : [ ]
  }, {
    "id" : 93690,
    "reactomeId" : 10647980,
    "displayName" : "DAG and IP3 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 637,
      "y" : 795
    },
    "minX" : 572,
    "maxX" : 702,
    "minY" : 768,
    "maxY" : 823,
    "prop" : {
      "x" : 572,
      "y" : 768,
      "width" : 130,
      "height" : 55
    },
    "textPosition" : {
      "x" : 588,
      "y" : 774
    },
    "connectors" : [ ]
  }, {
    "id" : 93693,
    "reactomeId" : 10648728,
    "displayName" : "RHO GTPases Activate Formins",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 2063,
      "y" : 466
    },
    "minX" : 2003,
    "maxX" : 2123,
    "minY" : 436,
    "maxY" : 496,
    "prop" : {
      "x" : 2003,
      "y" : 436,
      "width" : 120,
      "height" : 60
    },
    "textPosition" : {
      "x" : 2003,
      "y" : 444
    },
    "connectors" : [ ]
  }, {
    "id" : 93692,
    "reactomeId" : 10650230,
    "displayName" : "Signaling by PTK6",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 2096,
      "y" : 870
    },
    "minX" : 2020,
    "maxX" : 2172,
    "minY" : 848,
    "maxY" : 893,
    "prop" : {
      "x" : 2020,
      "y" : 848,
      "width" : 152,
      "height" : 45
    },
    "textPosition" : {
      "x" : 2033,
      "y" : 856
    },
    "connectors" : [ ]
  } ],
  "edges" : [ {
    "id" : 93637,
    "reactomeId" : 10598543,
    "displayName" : "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1343,
      "y" : 520
    },
    "minX" : 1337,
    "maxX" : 1349,
    "minY" : 502,
    "maxY" : 571,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1348,
        "y" : 502
      },
      "to" : {
        "x" : 1343,
        "y" : 520
      }
    }, {
      "from" : {
        "x" : 1343,
        "y" : 520
      },
      "to" : {
        "x" : 1339,
        "y" : 571
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1337,
        "y" : 514
      },
      "b" : {
        "x" : 1349,
        "y" : 526
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1343,
        "y" : 520
      }
    },
    "inputs" : [ {
      "id" : 93638,
      "points" : [ {
        "x" : 1316,
        "y" : 498
      } ],
      "stoichiometry" : 43
    }, {
      "id" : 93634,
      "points" : [ {
        "x" : 1344,
        "y" : 475
      } ]
    } ],
    "outputs" : [ {
      "id" : 93639,
      "points" : [ {
        "x" : 1305,
        "y" : 579
      } ],
      "stoichiometry" : 43
    }, {
      "id" : 93640,
      "points" : [ {
        "x" : 1453,
        "y" : 476
      }, {
        "x" : 1368,
        "y" : 575
      } ]
    } ],
    "catalysts" : [ {
      "id" : 93634,
      "points" : [ {
        "x" : 1354,
        "y" : 475
      }, {
        "x" : 1377,
        "y" : 502
      } ]
    } ]
  }, {
    "id" : 93574,
    "reactomeId" : 10594260,
    "displayName" : "ERBB3 binds neuregulins",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1238,
      "y" : 107
    },
    "minX" : 1157,
    "maxX" : 1280,
    "minY" : 101,
    "maxY" : 113,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1280,
        "y" : 102
      },
      "to" : {
        "x" : 1238,
        "y" : 107
      }
    }, {
      "from" : {
        "x" : 1238,
        "y" : 107
      },
      "to" : {
        "x" : 1157,
        "y" : 109
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1164,
        "y" : 105
      },
      "b" : {
        "x" : 1157,
        "y" : 109
      },
      "c" : {
        "x" : 1164,
        "y" : 113
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1164,
        "y" : 113
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1238,
        "y" : 107
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1238,
        "y" : 107
      }
    },
    "inputs" : [ {
      "id" : 93575,
      "points" : [ {
        "x" : 1272,
        "y" : 27
      } ]
    }, {
      "id" : 93576,
      "points" : [ {
        "x" : 1825,
        "y" : 242
      }, {
        "x" : 1725,
        "y" : 115
      } ]
    } ],
    "outputs" : [ {
      "id" : 93577
    } ]
  }, {
    "id" : 93641,
    "reactomeId" : 10598564,
    "displayName" : "Trans-autophosphorylation of ERBB2 heterodimers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1220,
      "y" : 349
    },
    "minX" : 1194,
    "maxX" : 1266,
    "minY" : 343,
    "maxY" : 355,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1194,
        "y" : 354
      },
      "to" : {
        "x" : 1220,
        "y" : 349
      }
    }, {
      "from" : {
        "x" : 1220,
        "y" : 349
      },
      "to" : {
        "x" : 1266,
        "y" : 350
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1214,
        "y" : 343
      },
      "b" : {
        "x" : 1226,
        "y" : 355
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1220,
        "y" : 349
      }
    },
    "inputs" : [ {
      "id" : 93633,
      "points" : [ {
        "x" : 1178,
        "y" : 398
      } ],
      "stoichiometry" : 43
    }, {
      "id" : 93632,
      "points" : [ {
        "x" : 1142,
        "y" : 367
      } ]
    } ],
    "outputs" : [ {
      "id" : 93642,
      "points" : [ {
        "x" : 1312,
        "y" : 361
      } ]
    }, {
      "id" : 93635,
      "points" : [ {
        "x" : 1266,
        "y" : 398
      } ],
      "stoichiometry" : 43
    } ],
    "catalysts" : [ {
      "id" : 93632,
      "points" : [ {
        "x" : 1128,
        "y" : 355
      }, {
        "x" : 1191,
        "y" : 332
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 93643,
      "points" : [ {
        "x" : 772,
        "y" : 243
      }, {
        "x" : 780,
        "y" : 307
      }, {
        "x" : 1206,
        "y" : 300
      } ]
    }, {
      "id" : 93644,
      "points" : [ {
        "x" : 562,
        "y" : 198
      }, {
        "x" : 611,
        "y" : 329
      }, {
        "x" : 1236,
        "y" : 317
      } ]
    } ]
  }, {
    "id" : 93578,
    "reactomeId" : 10594401,
    "displayName" : "SHC1 phosphorylation by ERBB2 heterodimers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1861,
      "y" : 1058
    },
    "minX" : 1827,
    "maxX" : 1891,
    "minY" : 1052,
    "maxY" : 1064,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1891,
        "y" : 1060
      },
      "to" : {
        "x" : 1861,
        "y" : 1058
      }
    }, {
      "from" : {
        "x" : 1861,
        "y" : 1058
      },
      "to" : {
        "x" : 1827,
        "y" : 1059
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1855,
        "y" : 1052
      },
      "b" : {
        "x" : 1867,
        "y" : 1064
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1861,
        "y" : 1058
      }
    },
    "inputs" : [ {
      "id" : 93579,
      "points" : [ {
        "x" : 1898,
        "y" : 1022
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 93580,
      "points" : [ {
        "x" : 1932,
        "y" : 1056
      } ]
    } ],
    "outputs" : [ {
      "id" : 93581,
      "points" : [ {
        "x" : 1822,
        "y" : 1012
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 93582,
      "points" : [ {
        "x" : 1801,
        "y" : 1065
      } ]
    } ],
    "catalysts" : [ {
      "id" : 93580,
      "points" : [ {
        "x" : 1986,
        "y" : 1081
      }, {
        "x" : 1971,
        "y" : 1112
      }, {
        "x" : 1836,
        "y" : 1113
      } ]
    } ]
  }, {
    "id" : 93645,
    "reactomeId" : 10594948,
    "displayName" : "Self-ubiquitination of RNF41",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2167,
      "y" : 721
    },
    "minX" : 2142,
    "maxX" : 2207,
    "minY" : 715,
    "maxY" : 727,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2142,
        "y" : 718
      },
      "to" : {
        "x" : 2167,
        "y" : 721
      }
    }, {
      "from" : {
        "x" : 2167,
        "y" : 721
      },
      "to" : {
        "x" : 2207,
        "y" : 719
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2200,
        "y" : 723
      },
      "b" : {
        "x" : 2207,
        "y" : 719
      },
      "c" : {
        "x" : 2200,
        "y" : 715
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2200,
        "y" : 715
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2161,
        "y" : 715
      },
      "b" : {
        "x" : 2173,
        "y" : 727
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2167,
        "y" : 721
      }
    },
    "inputs" : [ {
      "id" : 93601,
      "points" : [ {
        "x" : 2193,
        "y" : 678
      } ]
    }, {
      "id" : 93646,
      "points" : [ {
        "x" : 2121,
        "y" : 740
      } ]
    } ],
    "outputs" : [ {
      "id" : 93607
    } ],
    "catalysts" : [ {
      "id" : 93601,
      "points" : [ {
        "x" : 2199,
        "y" : 678
      } ]
    } ]
  }, {
    "id" : 93647,
    "reactomeId" : 10598526,
    "displayName" : "MATK (CSK homologous kinase) binds phosphorylated ERBB2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1844,
      "y" : 432
    },
    "minX" : 1831,
    "maxX" : 1851,
    "minY" : 355,
    "maxY" : 487,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1831,
        "y" : 487
      },
      "to" : {
        "x" : 1844,
        "y" : 432
      }
    }, {
      "from" : {
        "x" : 1844,
        "y" : 432
      },
      "to" : {
        "x" : 1851,
        "y" : 355
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1854,
        "y" : 362
      },
      "b" : {
        "x" : 1851,
        "y" : 355
      },
      "c" : {
        "x" : 1846,
        "y" : 362
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1846,
        "y" : 362
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1844,
        "y" : 432
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1844,
        "y" : 432
      }
    },
    "inputs" : [ {
      "id" : 93648,
      "points" : [ {
        "x" : 1664,
        "y" : 324
      } ]
    }, {
      "id" : 93649,
      "points" : [ {
        "x" : 1869,
        "y" : 578
      } ]
    } ],
    "outputs" : [ {
      "id" : 93650
    } ]
  }, {
    "id" : 93583,
    "reactomeId" : 10594463,
    "displayName" : "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2948,
      "y" : 708
    },
    "minX" : 2930,
    "maxX" : 2954,
    "minY" : 663,
    "maxY" : 746,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2930,
        "y" : 663
      },
      "to" : {
        "x" : 2948,
        "y" : 708
      }
    }, {
      "from" : {
        "x" : 2948,
        "y" : 708
      },
      "to" : {
        "x" : 2949,
        "y" : 746
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2942,
        "y" : 702
      },
      "b" : {
        "x" : 2954,
        "y" : 714
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2948,
        "y" : 708
      }
    },
    "inputs" : [ {
      "id" : 93584,
      "points" : [ {
        "x" : 2943,
        "y" : 641
      } ]
    }, {
      "id" : 93585,
      "points" : [ {
        "x" : 2887,
        "y" : 673
      } ]
    } ],
    "outputs" : [ {
      "id" : 93586,
      "points" : [ {
        "x" : 2953,
        "y" : 819
      } ]
    }, {
      "id" : 93587,
      "points" : [ {
        "x" : 2903,
        "y" : 761
      } ]
    } ],
    "catalysts" : [ {
      "id" : 93588,
      "points" : [ {
        "x" : 2980,
        "y" : 556
      }, {
        "x" : 3031,
        "y" : 560
      }, {
        "x" : 3026,
        "y" : 707
      } ]
    } ]
  }, {
    "id" : 93651,
    "reactomeId" : 10621386,
    "displayName" : "Phosphorylated ERBB2 heterodimers bind MEMO1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1876,
      "y" : 424
    },
    "minX" : 1870,
    "maxX" : 1896,
    "minY" : 411,
    "maxY" : 473,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1872,
        "y" : 473
      },
      "to" : {
        "x" : 1876,
        "y" : 424
      }
    }, {
      "from" : {
        "x" : 1876,
        "y" : 424
      },
      "to" : {
        "x" : 1896,
        "y" : 411
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1892,
        "y" : 418
      },
      "b" : {
        "x" : 1896,
        "y" : 411
      },
      "c" : {
        "x" : 1888,
        "y" : 411
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1888,
        "y" : 411
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1876,
        "y" : 424
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1876,
        "y" : 424
      }
    },
    "inputs" : [ {
      "id" : 93648,
      "points" : [ {
        "x" : 1670,
        "y" : 324
      } ]
    }, {
      "id" : 93652,
      "points" : [ {
        "x" : 1921,
        "y" : 602
      } ]
    } ],
    "outputs" : [ {
      "id" : 93653
    } ]
  }, {
    "id" : 93589,
    "reactomeId" : 10594446,
    "displayName" : "Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2897,
      "y" : 401
    },
    "minX" : 2878,
    "maxX" : 2923,
    "minY" : 395,
    "maxY" : 408,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2878,
        "y" : 399
      },
      "to" : {
        "x" : 2897,
        "y" : 401
      }
    }, {
      "from" : {
        "x" : 2897,
        "y" : 401
      },
      "to" : {
        "x" : 2923,
        "y" : 408
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2915,
        "y" : 410
      },
      "b" : {
        "x" : 2923,
        "y" : 408
      },
      "c" : {
        "x" : 2917,
        "y" : 402
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2917,
        "y" : 402
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2897,
        "y" : 401
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2897,
        "y" : 401
      }
    },
    "inputs" : [ {
      "id" : 93590,
      "points" : [ {
        "x" : 2814,
        "y" : 373
      } ]
    }, {
      "id" : 93591,
      "points" : [ {
        "x" : 2893,
        "y" : 342
      } ]
    } ],
    "outputs" : [ {
      "id" : 93592
    } ]
  }, {
    "id" : 93654,
    "reactomeId" : 10629148,
    "displayName" : "Activated ERBB2 binds PTK6 (BRK)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1967,
      "y" : 655
    },
    "minX" : 1885,
    "maxX" : 2021,
    "minY" : 567,
    "maxY" : 671,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1885,
        "y" : 671
      },
      "to" : {
        "x" : 1967,
        "y" : 655
      }
    }, {
      "from" : {
        "x" : 1967,
        "y" : 655
      },
      "to" : {
        "x" : 2021,
        "y" : 567
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2021,
        "y" : 575
      },
      "b" : {
        "x" : 2021,
        "y" : 567
      },
      "c" : {
        "x" : 2014,
        "y" : 571
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2014,
        "y" : 571
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1967,
        "y" : 655
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1967,
        "y" : 655
      }
    },
    "inputs" : [ {
      "id" : 93648,
      "points" : [ {
        "x" : 1656,
        "y" : 324
      } ]
    }, {
      "id" : 93655,
      "points" : [ {
        "x" : 1897,
        "y" : 709
      } ]
    } ],
    "outputs" : [ {
      "id" : 93656
    } ]
  }, {
    "id" : 93657,
    "reactomeId" : 10629154,
    "displayName" : "ERBB2 promotes PTK6 autophosphorylation",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2032,
      "y" : 679
    },
    "minX" : 2026,
    "maxX" : 2038,
    "minY" : 625,
    "maxY" : 721,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2031,
        "y" : 625
      },
      "to" : {
        "x" : 2032,
        "y" : 679
      }
    }, {
      "from" : {
        "x" : 2032,
        "y" : 679
      },
      "to" : {
        "x" : 2030,
        "y" : 721
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2026,
        "y" : 673
      },
      "b" : {
        "x" : 2038,
        "y" : 685
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2032,
        "y" : 679
      }
    },
    "inputs" : [ {
      "id" : 93658,
      "points" : [ {
        "x" : 2049,
        "y" : 616
      } ]
    }, {
      "id" : 93656,
      "points" : [ {
        "x" : 2033,
        "y" : 567
      } ]
    } ],
    "outputs" : [ {
      "id" : 93659,
      "points" : [ {
        "x" : 2040,
        "y" : 780
      } ]
    }, {
      "id" : 93648,
      "points" : [ {
        "x" : 1653,
        "y" : 324
      }, {
        "x" : 1903,
        "y" : 825
      } ]
    }, {
      "id" : 93660,
      "points" : [ {
        "x" : 2045,
        "y" : 726
      } ]
    } ],
    "catalysts" : [ {
      "id" : 93656,
      "points" : [ {
        "x" : 2027,
        "y" : 567
      }, {
        "x" : 2008,
        "y" : 629
      } ]
    } ]
  }, {
    "id" : 93593,
    "reactomeId" : 10594936,
    "displayName" : "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2981,
      "y" : 694
    },
    "minX" : 2945,
    "maxX" : 2987,
    "minY" : 668,
    "maxY" : 751,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2945,
        "y" : 668
      },
      "to" : {
        "x" : 2981,
        "y" : 694
      }
    }, {
      "from" : {
        "x" : 2981,
        "y" : 694
      },
      "to" : {
        "x" : 2957,
        "y" : 751
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2975,
        "y" : 688
      },
      "b" : {
        "x" : 2987,
        "y" : 700
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2981,
        "y" : 694
      }
    },
    "inputs" : [ {
      "id" : 93584,
      "points" : [ {
        "x" : 2949,
        "y" : 641
      } ]
    }, {
      "id" : 93585,
      "points" : [ {
        "x" : 2887,
        "y" : 675
      } ]
    } ],
    "outputs" : [ {
      "id" : 93587,
      "points" : [ {
        "x" : 2903,
        "y" : 763
      } ]
    }, {
      "id" : 93586,
      "points" : [ {
        "x" : 2954,
        "y" : 819
      } ]
    } ],
    "catalysts" : [ {
      "id" : 93592,
      "points" : [ {
        "x" : 3024,
        "y" : 418
      }, {
        "x" : 3075,
        "y" : 417
      }, {
        "x" : 3073,
        "y" : 663
      } ]
    } ]
  }, {
    "id" : 93594,
    "reactomeId" : 10594933,
    "displayName" : "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1411,
      "y" : 1101
    },
    "minX" : 1381,
    "maxX" : 1433,
    "minY" : 1068,
    "maxY" : 1107,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1381,
        "y" : 1068
      },
      "to" : {
        "x" : 1411,
        "y" : 1101
      }
    }, {
      "from" : {
        "x" : 1411,
        "y" : 1101
      },
      "to" : {
        "x" : 1433,
        "y" : 1080
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1405,
        "y" : 1095
      },
      "b" : {
        "x" : 1417,
        "y" : 1107
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1411,
        "y" : 1101
      }
    },
    "inputs" : [ {
      "id" : 93595,
      "points" : [ {
        "x" : 1364,
        "y" : 1082
      } ]
    }, {
      "id" : 93596,
      "points" : [ {
        "x" : 1379,
        "y" : 1020
      } ]
    } ],
    "outputs" : [ {
      "id" : 93597,
      "points" : [ {
        "x" : 1437,
        "y" : 1018
      } ]
    }, {
      "id" : 93598,
      "points" : [ {
        "x" : 1460,
        "y" : 1082
      } ]
    } ],
    "catalysts" : [ {
      "id" : 93599,
      "points" : [ {
        "x" : 2123,
        "y" : 1087
      }, {
        "x" : 2108,
        "y" : 1162
      }, {
        "x" : 1411,
        "y" : 1167
      } ]
    } ]
  }, {
    "id" : 93661,
    "reactomeId" : 10594346,
    "displayName" : "Binding of PI3K to ERBB2:p-ERBB3 heterodimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2862,
      "y" : 510
    },
    "minX" : 2817,
    "maxX" : 2908,
    "minY" : 480,
    "maxY" : 536,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2817,
        "y" : 480
      },
      "to" : {
        "x" : 2862,
        "y" : 510
      }
    }, {
      "from" : {
        "x" : 2862,
        "y" : 510
      },
      "to" : {
        "x" : 2908,
        "y" : 536
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2900,
        "y" : 536
      },
      "b" : {
        "x" : 2908,
        "y" : 536
      },
      "c" : {
        "x" : 2904,
        "y" : 529
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2904,
        "y" : 529
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2862,
        "y" : 510
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2862,
        "y" : 510
      }
    },
    "inputs" : [ {
      "id" : 93618,
      "points" : [ {
        "x" : 2549,
        "y" : 319
      } ]
    }, {
      "id" : 93591,
      "points" : [ {
        "x" : 2888,
        "y" : 342
      } ]
    } ],
    "outputs" : [ {
      "id" : 93588
    } ]
  }, {
    "id" : 93662,
    "reactomeId" : 10631125,
    "displayName" : "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1504,
      "y" : 563
    },
    "minX" : 1498,
    "maxX" : 1524,
    "minY" : 510,
    "maxY" : 602,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1524,
        "y" : 510
      },
      "to" : {
        "x" : 1504,
        "y" : 563
      }
    }, {
      "from" : {
        "x" : 1504,
        "y" : 563
      },
      "to" : {
        "x" : 1498,
        "y" : 602
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1498,
        "y" : 557
      },
      "b" : {
        "x" : 1510,
        "y" : 569
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1504,
        "y" : 563
      }
    },
    "inputs" : [ {
      "id" : 93663,
      "points" : [ {
        "x" : 1425,
        "y" : 565
      }, {
        "x" : 1493,
        "y" : 499
      } ]
    }, {
      "id" : 93648,
      "points" : [ {
        "x" : 1631,
        "y" : 324
      } ]
    } ],
    "outputs" : [ {
      "id" : 93664,
      "points" : [ {
        "x" : 1550,
        "y" : 576
      } ]
    }, {
      "id" : 93665,
      "points" : [ {
        "x" : 1462,
        "y" : 655
      } ]
    } ],
    "catalysts" : [ {
      "id" : 93666,
      "points" : [ {
        "x" : 1415,
        "y" : 624
      } ]
    } ]
  }, {
    "id" : 93600,
    "reactomeId" : 10594982,
    "displayName" : "ERBB3 binds RNF41 ubiquitin ligase",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2114,
      "y" : 270
    },
    "minX" : 2096,
    "maxX" : 2196,
    "minY" : 264,
    "maxY" : 276,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2096,
        "y" : 271
      },
      "to" : {
        "x" : 2114,
        "y" : 270
      }
    }, {
      "from" : {
        "x" : 2114,
        "y" : 270
      },
      "to" : {
        "x" : 2196,
        "y" : 266
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2189,
        "y" : 270
      },
      "b" : {
        "x" : 2196,
        "y" : 266
      },
      "c" : {
        "x" : 2189,
        "y" : 262
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2189,
        "y" : 262
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2114,
        "y" : 270
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2114,
        "y" : 270
      }
    },
    "inputs" : [ {
      "id" : 93601,
      "points" : [ {
        "x" : 2205,
        "y" : 644
      } ]
    }, {
      "id" : 93576,
      "points" : [ {
        "x" : 1879,
        "y" : 262
      }, {
        "x" : 2061,
        "y" : 272
      } ]
    } ],
    "outputs" : [ {
      "id" : 93602
    } ]
  }, {
    "id" : 93667,
    "reactomeId" : 10631367,
    "displayName" : "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 927,
      "y" : 1133
    },
    "minX" : 906,
    "maxX" : 969,
    "minY" : 1120,
    "maxY" : 1139,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 969,
        "y" : 1131
      },
      "to" : {
        "x" : 927,
        "y" : 1133
      }
    }, {
      "from" : {
        "x" : 927,
        "y" : 1133
      },
      "to" : {
        "x" : 906,
        "y" : 1120
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 921,
        "y" : 1127
      },
      "b" : {
        "x" : 933,
        "y" : 1139
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 927,
        "y" : 1133
      }
    },
    "inputs" : [ {
      "id" : 93668,
      "points" : [ {
        "x" : 988,
        "y" : 1152
      } ]
    }, {
      "id" : 93669,
      "points" : [ {
        "x" : 967,
        "y" : 1039
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 93670,
      "points" : [ {
        "x" : 865,
        "y" : 1140
      } ]
    }, {
      "id" : 93671,
      "points" : [ {
        "x" : 906,
        "y" : 1036
      } ],
      "stoichiometry" : 3
    } ],
    "catalysts" : [ {
      "id" : 93668,
      "points" : [ {
        "x" : 954,
        "y" : 1187
      }, {
        "x" : 919,
        "y" : 1189
      } ]
    } ]
  }, {
    "id" : 93603,
    "reactomeId" : 10594955,
    "displayName" : "RNF41 ubiquitinates ERBB3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2221,
      "y" : 375
    },
    "minX" : 2212,
    "maxX" : 2227,
    "minY" : 346,
    "maxY" : 447,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2216,
        "y" : 346
      },
      "to" : {
        "x" : 2221,
        "y" : 375
      }
    }, {
      "from" : {
        "x" : 2221,
        "y" : 375
      },
      "to" : {
        "x" : 2212,
        "y" : 447
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2215,
        "y" : 369
      },
      "b" : {
        "x" : 2227,
        "y" : 381
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2221,
        "y" : 375
      }
    },
    "inputs" : [ {
      "id" : 93602,
      "points" : [ {
        "x" : 2222,
        "y" : 288
      } ]
    }, {
      "id" : 93604,
      "points" : [ {
        "x" : 2193,
        "y" : 337
      } ]
    } ],
    "outputs" : [ {
      "id" : 93605,
      "points" : [ {
        "x" : 2238,
        "y" : 440
      } ]
    }, {
      "id" : 93601,
      "points" : [ {
        "x" : 2210,
        "y" : 644
      } ]
    } ],
    "catalysts" : [ {
      "id" : 93602,
      "points" : [ {
        "x" : 2232,
        "y" : 288
      }, {
        "x" : 2253,
        "y" : 336
      } ]
    } ]
  }, {
    "id" : 93606,
    "reactomeId" : 10594978,
    "displayName" : "Ubiquitinated RNF41 binds P-USP8",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2368,
      "y" : 763
    },
    "minX" : 2362,
    "maxX" : 2391,
    "minY" : 737,
    "maxY" : 796,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2391,
        "y" : 796
      },
      "to" : {
        "x" : 2368,
        "y" : 763
      }
    }, {
      "from" : {
        "x" : 2368,
        "y" : 763
      },
      "to" : {
        "x" : 2366,
        "y" : 737
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2371,
        "y" : 744
      },
      "b" : {
        "x" : 2366,
        "y" : 737
      },
      "c" : {
        "x" : 2363,
        "y" : 744
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2363,
        "y" : 744
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2368,
        "y" : 763
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2368,
        "y" : 763
      }
    },
    "inputs" : [ {
      "id" : 93607,
      "points" : [ {
        "x" : 2268,
        "y" : 732
      } ]
    }, {
      "id" : 93608,
      "points" : [ {
        "x" : 2463,
        "y" : 681
      }, {
        "x" : 2459,
        "y" : 777
      } ]
    } ],
    "outputs" : [ {
      "id" : 93609
    } ]
  }, {
    "id" : 93672,
    "reactomeId" : 10639875,
    "displayName" : "ERBB2 binds TKIs",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 541,
      "y" : 275
    },
    "minX" : 535,
    "maxX" : 584,
    "minY" : 198,
    "maxY" : 342,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 584,
        "y" : 342
      },
      "to" : {
        "x" : 541,
        "y" : 275
      }
    }, {
      "from" : {
        "x" : 541,
        "y" : 275
      },
      "to" : {
        "x" : 553,
        "y" : 198
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 556,
        "y" : 205
      },
      "b" : {
        "x" : 553,
        "y" : 198
      },
      "c" : {
        "x" : 548,
        "y" : 204
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 548,
        "y" : 204
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 541,
        "y" : 275
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 541,
        "y" : 275
      }
    },
    "inputs" : [ {
      "id" : 93673,
      "points" : [ {
        "x" : 565,
        "y" : 424
      } ]
    }, {
      "id" : 93627,
      "points" : [ {
        "x" : 641,
        "y" : 351
      } ]
    } ],
    "outputs" : [ {
      "id" : 93644
    } ]
  }, {
    "id" : 93610,
    "reactomeId" : 10594976,
    "displayName" : "Deubiquitination of RNF41 by P-USP8",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2364,
      "y" : 654
    },
    "minX" : 2358,
    "maxX" : 2370,
    "minY" : 648,
    "maxY" : 694,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2364,
        "y" : 694
      },
      "to" : {
        "x" : 2364,
        "y" : 654
      }
    }, {
      "from" : {
        "x" : 2364,
        "y" : 654
      },
      "to" : {
        "x" : 2362,
        "y" : 654
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2358,
        "y" : 648
      },
      "b" : {
        "x" : 2370,
        "y" : 660
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2364,
        "y" : 654
      }
    },
    "inputs" : [ {
      "id" : 93609
    } ],
    "outputs" : [ {
      "id" : 93608,
      "points" : [ {
        "x" : 2412,
        "y" : 659
      } ]
    }, {
      "id" : 93601,
      "points" : [ {
        "x" : 2243,
        "y" : 659
      } ]
    }, {
      "id" : 93611,
      "points" : [ {
        "x" : 2362,
        "y" : 614
      } ]
    } ],
    "catalysts" : [ {
      "id" : 93609,
      "points" : [ {
        "x" : 2347,
        "y" : 694
      }, {
        "x" : 2336,
        "y" : 684
      } ]
    } ]
  }, {
    "id" : 93612,
    "reactomeId" : 10594964,
    "displayName" : "Phosphorylation of USP8 by P-AKT",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2555,
      "y" : 635
    },
    "minX" : 2520,
    "maxX" : 2592,
    "minY" : 629,
    "maxY" : 641,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2592,
        "y" : 634
      },
      "to" : {
        "x" : 2555,
        "y" : 635
      }
    }, {
      "from" : {
        "x" : 2555,
        "y" : 635
      },
      "to" : {
        "x" : 2520,
        "y" : 634
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2549,
        "y" : 629
      },
      "b" : {
        "x" : 2561,
        "y" : 641
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2555,
        "y" : 635
      }
    },
    "inputs" : [ {
      "id" : 93613,
      "points" : [ {
        "x" : 2630,
        "y" : 642
      } ]
    }, {
      "id" : 93614,
      "points" : [ {
        "x" : 2615,
        "y" : 616
      } ]
    } ],
    "outputs" : [ {
      "id" : 93615,
      "points" : [ {
        "x" : 2509,
        "y" : 612
      } ]
    }, {
      "id" : 93608,
      "points" : [ {
        "x" : 2489,
        "y" : 648
      } ]
    } ],
    "catalysts" : [ {
      "id" : 93616,
      "points" : [ {
        "x" : 2552,
        "y" : 695
      } ]
    } ]
  }, {
    "id" : 93617,
    "reactomeId" : 10594980,
    "displayName" : "RNF41 binds neuregulin-activated ERBB3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2396,
      "y" : 370
    },
    "minX" : 2356,
    "maxX" : 2402,
    "minY" : 343,
    "maxY" : 409,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2356,
        "y" : 343
      },
      "to" : {
        "x" : 2396,
        "y" : 370
      }
    }, {
      "from" : {
        "x" : 2396,
        "y" : 370
      },
      "to" : {
        "x" : 2396,
        "y" : 409
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2392,
        "y" : 402
      },
      "b" : {
        "x" : 2396,
        "y" : 409
      },
      "c" : {
        "x" : 2400,
        "y" : 402
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2400,
        "y" : 402
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2396,
        "y" : 370
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2396,
        "y" : 370
      }
    },
    "inputs" : [ {
      "id" : 93601,
      "points" : [ {
        "x" : 2216,
        "y" : 644
      } ]
    }, {
      "id" : 93618,
      "points" : [ {
        "x" : 2449,
        "y" : 307
      } ]
    } ],
    "outputs" : [ {
      "id" : 93619
    } ]
  }, {
    "id" : 93620,
    "reactomeId" : 10594971,
    "displayName" : "RNF41 ubiquitinates activated ERBB3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2360,
      "y" : 513
    },
    "minX" : 2335,
    "maxX" : 2366,
    "minY" : 477,
    "maxY" : 555,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2363,
        "y" : 477
      },
      "to" : {
        "x" : 2360,
        "y" : 513
      }
    }, {
      "from" : {
        "x" : 2360,
        "y" : 513
      },
      "to" : {
        "x" : 2335,
        "y" : 555
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2354,
        "y" : 507
      },
      "b" : {
        "x" : 2366,
        "y" : 519
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2360,
        "y" : 513
      }
    },
    "inputs" : [ {
      "id" : 93619,
      "points" : [ {
        "x" : 2377,
        "y" : 463
      } ]
    }, {
      "id" : 93621,
      "points" : [ {
        "x" : 2345,
        "y" : 482
      } ]
    } ],
    "outputs" : [ {
      "id" : 93622,
      "points" : [ {
        "x" : 2405,
        "y" : 544
      } ]
    }, {
      "id" : 93601,
      "points" : [ {
        "x" : 2226,
        "y" : 644
      } ]
    } ],
    "catalysts" : [ {
      "id" : 93619,
      "points" : [ {
        "x" : 2398,
        "y" : 463
      }, {
        "x" : 2401,
        "y" : 494
      } ]
    } ]
  }, {
    "id" : 93623,
    "reactomeId" : 10594930,
    "displayName" : "GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2178,
      "y" : 958
    },
    "minX" : 2144,
    "maxX" : 2185,
    "minY" : 931,
    "maxY" : 1020,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2185,
        "y" : 931
      },
      "to" : {
        "x" : 2178,
        "y" : 958
      }
    }, {
      "from" : {
        "x" : 2178,
        "y" : 958
      },
      "to" : {
        "x" : 2144,
        "y" : 1020
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2144,
        "y" : 1012
      },
      "b" : {
        "x" : 2144,
        "y" : 1020
      },
      "c" : {
        "x" : 2151,
        "y" : 1016
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2151,
        "y" : 1016
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2178,
        "y" : 958
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2178,
        "y" : 958
      }
    },
    "inputs" : [ {
      "id" : 93624,
      "points" : [ {
        "x" : 2245,
        "y" : 1023
      } ]
    }, {
      "id" : 93625,
      "points" : [ {
        "x" : 1702,
        "y" : 882
      } ]
    } ],
    "outputs" : [ {
      "id" : 93599
    } ]
  }, {
    "id" : 93626,
    "reactomeId" : 10598468,
    "displayName" : "CUL5 mediates ubiquitination of ERBB2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 682,
      "y" : 525
    },
    "minX" : 664,
    "maxX" : 688,
    "minY" : 453,
    "maxY" : 663,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 684,
        "y" : 453
      },
      "to" : {
        "x" : 682,
        "y" : 525
      }
    }, {
      "from" : {
        "x" : 682,
        "y" : 525
      },
      "to" : {
        "x" : 664,
        "y" : 663
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 661,
        "y" : 656
      },
      "b" : {
        "x" : 664,
        "y" : 663
      },
      "c" : {
        "x" : 669,
        "y" : 657
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 669,
        "y" : 657
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 676,
        "y" : 519
      },
      "b" : {
        "x" : 688,
        "y" : 531
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 682,
        "y" : 525
      }
    },
    "inputs" : [ {
      "id" : 93627,
      "points" : [ {
        "x" : 712,
        "y" : 389
      } ]
    }, {
      "id" : 93628,
      "points" : [ {
        "x" : 749,
        "y" : 494
      } ]
    } ],
    "outputs" : [ {
      "id" : 93629
    } ],
    "catalysts" : [ {
      "id" : 93630,
      "points" : [ {
        "x" : 867,
        "y" : 586
      } ]
    } ]
  }, {
    "id" : 93631,
    "reactomeId" : 10598578,
    "displayName" : "SRC family kinases phosphorylate ERBB2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1191,
      "y" : 450
    },
    "minX" : 1146,
    "maxX" : 1234,
    "minY" : 443,
    "maxY" : 456,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1146,
        "y" : 443
      },
      "to" : {
        "x" : 1191,
        "y" : 450
      }
    }, {
      "from" : {
        "x" : 1191,
        "y" : 450
      },
      "to" : {
        "x" : 1234,
        "y" : 445
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1185,
        "y" : 444
      },
      "b" : {
        "x" : 1197,
        "y" : 456
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1191,
        "y" : 450
      }
    },
    "inputs" : [ {
      "id" : 93632,
      "points" : [ {
        "x" : 1105,
        "y" : 403
      } ]
    }, {
      "id" : 93633,
      "points" : [ {
        "x" : 1159,
        "y" : 433
      } ]
    } ],
    "outputs" : [ {
      "id" : 93634,
      "points" : [ {
        "x" : 1285,
        "y" : 448
      } ]
    }, {
      "id" : 93635,
      "points" : [ {
        "x" : 1251,
        "y" : 432
      } ]
    } ],
    "catalysts" : [ {
      "id" : 93636,
      "points" : [ {
        "x" : 1189,
        "y" : 498
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 93676,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1544,
      "y" : 685
    },
    "minX" : 0,
    "maxX" : 3089,
    "minY" : 47,
    "maxY" : 1323,
    "prop" : {
      "x" : 0,
      "y" : 47,
      "width" : 3089,
      "height" : 1276
    },
    "textPosition" : {
      "x" : 987,
      "y" : 874
    },
    "insets" : {
      "x" : 10,
      "y" : 57,
      "width" : 3069,
      "height" : 1256
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 93627, 93576, 93682, 93600, 93606, 93608, 93609, 93612, 93613, 93614, 93615, 93601, 93617, 93607, 93610, 93646, 93602, 93603, 93605, 93588, 93592, 93622, 93577, 93585, 93587, 93583, 93593, 93683, 93701, 93596, 93597, 93623, 93625, 93582, 93598, 93594, 93595, 93604, 93616, 93702, 93580, 93579, 93581, 93578, 93599, 93620, 93584, 93586, 93636, 93628, 93626, 93629, 93630, 93703, 93632, 93687, 93631, 93634, 93637, 93638, 93641, 93633, 93624, 93704, 93648, 93689, 93618, 93645, 93611, 93619, 93621, 93590, 93690, 93705, 93642, 93635, 93640, 93639, 93650, 93647, 93649, 93691, 93711, 93651, 93652, 93653, 93709, 93654, 93655, 93656, 93657, 93658, 93659, 93660, 93692, 93712, 93713, 93693, 93714, 93706, 93708, 93591, 93589, 93661, 93662, 93663, 93664, 93665, 93666, 93668, 93667, 93669, 93670, 93671, 93696, 93574, 93707, 93710, 93695, 93672, 93673, 93643, 93644, 93715, 93716, 93717 ]
  } ],
  "notes" : [ {
    "id" : 93696,
    "displayName" : "plasma membrane",
    "renderableClass" : "Note",
    "position" : {
      "x" : 2339,
      "y" : 1199
    },
    "minX" : 2276,
    "maxX" : 2403,
    "minY" : 1185,
    "maxY" : 1213,
    "prop" : {
      "x" : 2276,
      "y" : 1185,
      "width" : 127,
      "height" : 28
    },
    "textPosition" : {
      "x" : 2277,
      "y" : 1188
    }
  }, {
    "id" : 93695,
    "displayName" : "plasma membrane",
    "renderableClass" : "Note",
    "position" : {
      "x" : 585,
      "y" : 95
    },
    "minX" : 522,
    "maxX" : 649,
    "minY" : 81,
    "maxY" : 109,
    "prop" : {
      "x" : 522,
      "y" : 81,
      "width" : 127,
      "height" : 28
    },
    "textPosition" : {
      "x" : 523,
      "y" : 84
    }
  } ],
  "links" : [ {
    "id" : 93701,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2780,
      "y" : 886
    },
    "minX" : 2650,
    "maxX" : 2911,
    "minY" : 848,
    "maxY" : 924,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2911,
        "y" : 848
      },
      "to" : {
        "x" : 2650,
        "y" : 924
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2656,
        "y" : 918
      },
      "b" : {
        "x" : 2650,
        "y" : 924
      },
      "c" : {
        "x" : 2658,
        "y" : 926
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2658,
        "y" : 926
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2774,
        "y" : 880
      },
      "b" : {
        "x" : 2786,
        "y" : 892
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2780,
        "y" : 886
      }
    },
    "inputs" : [ {
      "id" : 93586
    } ],
    "outputs" : [ {
      "id" : 93683
    } ]
  }, {
    "id" : 93703,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1007,
      "y" : 181
    },
    "minX" : 928,
    "maxX" : 1086,
    "minY" : 133,
    "maxY" : 230,
    "segments" : [ {
      "from" : {
        "x" : 1086,
        "y" : 133
      },
      "to" : {
        "x" : 928,
        "y" : 230
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1001,
        "y" : 175
      },
      "b" : {
        "x" : 1013,
        "y" : 187
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1007,
        "y" : 181
      }
    },
    "inputs" : [ {
      "id" : 93577
    } ],
    "outputs" : [ {
      "id" : 93687
    } ]
  }, {
    "id" : 93702,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2563,
      "y" : 823
    },
    "minX" : 2553,
    "maxX" : 2573,
    "minY" : 740,
    "maxY" : 906,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2573,
        "y" : 906
      },
      "to" : {
        "x" : 2553,
        "y" : 740
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2558,
        "y" : 746
      },
      "b" : {
        "x" : 2553,
        "y" : 740
      },
      "c" : {
        "x" : 2550,
        "y" : 747
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2550,
        "y" : 747
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2557,
        "y" : 817
      },
      "b" : {
        "x" : 2569,
        "y" : 829
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2563,
        "y" : 823
      }
    },
    "inputs" : [ {
      "id" : 93683
    } ],
    "outputs" : [ {
      "id" : 93616
    } ]
  }, {
    "id" : 93705,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 725,
      "y" : 793
    },
    "minX" : 705,
    "maxX" : 746,
    "minY" : 787,
    "maxY" : 799,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 746,
        "y" : 793
      },
      "to" : {
        "x" : 705,
        "y" : 793
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 712,
        "y" : 789
      },
      "b" : {
        "x" : 705,
        "y" : 793
      },
      "c" : {
        "x" : 712,
        "y" : 797
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 712,
        "y" : 797
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 719,
        "y" : 787
      },
      "b" : {
        "x" : 731,
        "y" : 799
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 725,
        "y" : 793
      }
    },
    "inputs" : [ {
      "id" : 93682
    } ],
    "outputs" : [ {
      "id" : 93690
    } ]
  }, {
    "id" : 93704,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2680,
      "y" : 758
    },
    "minX" : 2298,
    "maxX" : 2747,
    "minY" : 384,
    "maxY" : 1023,
    "segments" : [ {
      "from" : {
        "x" : 2745,
        "y" : 384
      },
      "to" : {
        "x" : 2747,
        "y" : 564
      }
    }, {
      "from" : {
        "x" : 2747,
        "y" : 564
      },
      "to" : {
        "x" : 2680,
        "y" : 758
      }
    }, {
      "from" : {
        "x" : 2680,
        "y" : 758
      },
      "to" : {
        "x" : 2522,
        "y" : 882
      }
    }, {
      "from" : {
        "x" : 2522,
        "y" : 882
      },
      "to" : {
        "x" : 2298,
        "y" : 1023
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2674,
        "y" : 752
      },
      "b" : {
        "x" : 2686,
        "y" : 764
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2680,
        "y" : 758
      }
    },
    "inputs" : [ {
      "id" : 93590
    } ],
    "outputs" : [ {
      "id" : 93624
    } ]
  }, {
    "id" : 93707,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 2126,
      "y" : 166
    },
    "minX" : 1655,
    "maxX" : 2714,
    "minY" : 160,
    "maxY" : 317,
    "segments" : [ {
      "from" : {
        "x" : 2714,
        "y" : 317
      },
      "to" : {
        "x" : 2536,
        "y" : 163
      }
    }, {
      "from" : {
        "x" : 2536,
        "y" : 163
      },
      "to" : {
        "x" : 1717,
        "y" : 170
      }
    }, {
      "from" : {
        "x" : 1717,
        "y" : 170
      },
      "to" : {
        "x" : 1655,
        "y" : 269
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2120,
        "y" : 160
      },
      "b" : {
        "x" : 2132,
        "y" : 172
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2126,
        "y" : 166
      }
    },
    "inputs" : [ {
      "id" : 93590
    } ],
    "outputs" : [ {
      "id" : 93648
    } ]
  }, {
    "id" : 93706,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1559,
      "y" : 370
    },
    "minX" : 1501,
    "maxX" : 1617,
    "minY" : 324,
    "maxY" : 416,
    "segments" : [ {
      "from" : {
        "x" : 1501,
        "y" : 416
      },
      "to" : {
        "x" : 1617,
        "y" : 324
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1553,
        "y" : 364
      },
      "b" : {
        "x" : 1565,
        "y" : 376
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1559,
        "y" : 370
      }
    },
    "inputs" : [ {
      "id" : 93640
    } ],
    "outputs" : [ {
      "id" : 93648
    } ]
  }, {
    "id" : 93709,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 1951,
      "y" : 885
    },
    "minX" : 1654,
    "maxX" : 2215,
    "minY" : 324,
    "maxY" : 1023,
    "segments" : [ {
      "from" : {
        "x" : 2215,
        "y" : 1023
      },
      "to" : {
        "x" : 1951,
        "y" : 885
      }
    }, {
      "from" : {
        "x" : 1951,
        "y" : 885
      },
      "to" : {
        "x" : 1654,
        "y" : 324
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1945,
        "y" : 879
      },
      "b" : {
        "x" : 1957,
        "y" : 891
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1951,
        "y" : 885
      }
    },
    "inputs" : [ {
      "id" : 93624
    } ],
    "outputs" : [ {
      "id" : 93648
    } ]
  }, {
    "id" : 93708,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 1400,
      "y" : 822
    },
    "minX" : 1040,
    "maxX" : 1761,
    "minY" : 324,
    "maxY" : 1028,
    "segments" : [ {
      "from" : {
        "x" : 1080,
        "y" : 1028
      },
      "to" : {
        "x" : 1040,
        "y" : 942
      }
    }, {
      "from" : {
        "x" : 1040,
        "y" : 942
      },
      "to" : {
        "x" : 1761,
        "y" : 702
      }
    }, {
      "from" : {
        "x" : 1761,
        "y" : 702
      },
      "to" : {
        "x" : 1649,
        "y" : 324
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1394,
        "y" : 816
      },
      "b" : {
        "x" : 1406,
        "y" : 828
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1400,
        "y" : 822
      }
    },
    "inputs" : [ {
      "id" : 93689
    } ],
    "outputs" : [ {
      "id" : 93648
    } ]
  }, {
    "id" : 93711,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1488,
      "y" : 1015
    },
    "minX" : 1482,
    "maxX" : 1494,
    "minY" : 974,
    "maxY" : 1057,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1484,
        "y" : 1057
      },
      "to" : {
        "x" : 1493,
        "y" : 974
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1496,
        "y" : 981
      },
      "b" : {
        "x" : 1493,
        "y" : 974
      },
      "c" : {
        "x" : 1488,
        "y" : 980
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1488,
        "y" : 980
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1482,
        "y" : 1009
      },
      "b" : {
        "x" : 1494,
        "y" : 1021
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1488,
        "y" : 1015
      }
    },
    "inputs" : [ {
      "id" : 93598
    } ],
    "outputs" : [ {
      "id" : 93691
    } ]
  }, {
    "id" : 93710,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 1973,
      "y" : 190
    },
    "minX" : 1660,
    "maxX" : 2449,
    "minY" : 184,
    "maxY" : 269,
    "segments" : [ {
      "from" : {
        "x" : 1660,
        "y" : 269
      },
      "to" : {
        "x" : 1728,
        "y" : 191
      }
    }, {
      "from" : {
        "x" : 1728,
        "y" : 191
      },
      "to" : {
        "x" : 2218,
        "y" : 189
      }
    }, {
      "from" : {
        "x" : 2218,
        "y" : 189
      },
      "to" : {
        "x" : 2449,
        "y" : 269
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1967,
        "y" : 184
      },
      "b" : {
        "x" : 1979,
        "y" : 196
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1973,
        "y" : 190
      }
    },
    "inputs" : [ {
      "id" : 93648
    } ],
    "outputs" : [ {
      "id" : 93618
    } ]
  }, {
    "id" : 93713,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1514,
      "y" : 332
    },
    "minX" : 1436,
    "maxX" : 1593,
    "minY" : 308,
    "maxY" : 356,
    "segments" : [ {
      "from" : {
        "x" : 1436,
        "y" : 356
      },
      "to" : {
        "x" : 1593,
        "y" : 308
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1508,
        "y" : 326
      },
      "b" : {
        "x" : 1520,
        "y" : 338
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1514,
        "y" : 332
      }
    },
    "inputs" : [ {
      "id" : 93642
    } ],
    "outputs" : [ {
      "id" : 93648
    } ]
  }, {
    "id" : 93712,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2065,
      "y" : 829
    },
    "minX" : 2052,
    "maxX" : 2078,
    "minY" : 813,
    "maxY" : 845,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2052,
        "y" : 813
      },
      "to" : {
        "x" : 2078,
        "y" : 845
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2071,
        "y" : 842
      },
      "b" : {
        "x" : 2078,
        "y" : 845
      },
      "c" : {
        "x" : 2077,
        "y" : 837
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2077,
        "y" : 837
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2059,
        "y" : 823
      },
      "b" : {
        "x" : 2071,
        "y" : 835
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2065,
        "y" : 829
      }
    },
    "inputs" : [ {
      "id" : 93659
    } ],
    "outputs" : [ {
      "id" : 93692
    } ]
  } ],
  "shadows" : [ {
    "id" : 93715,
    "reactomeId" : 10649416,
    "displayName" : "SHC1 events in ERBB2 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1880,
      "y" : 1048
    },
    "minX" : 1688,
    "maxX" : 2072,
    "minY" : 969,
    "maxY" : 1128,
    "prop" : {
      "x" : 1688,
      "y" : 969,
      "width" : 384,
      "height" : 159
    },
    "points" : [ {
      "x" : 1688,
      "y" : 969
    }, {
      "x" : 2072,
      "y" : 969
    }, {
      "x" : 2072,
      "y" : 1128
    }, {
      "x" : 1688,
      "y" : 1128
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 93714,
    "reactomeId" : 10649414,
    "displayName" : "PI3K events in ERBB2 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 2738,
      "y" : 557
    },
    "minX" : 2445,
    "maxX" : 3031,
    "minY" : 253,
    "maxY" : 862,
    "prop" : {
      "x" : 2703,
      "y" : 253,
      "width" : 328,
      "height" : 609
    },
    "points" : [ {
      "x" : 2445,
      "y" : 253
    }, {
      "x" : 3031,
      "y" : 253
    }, {
      "x" : 3031,
      "y" : 862
    }, {
      "x" : 2445,
      "y" : 862
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 93717,
    "reactomeId" : 10649470,
    "displayName" : "Downregulation of ERBB2 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1645,
      "y" : 731
    },
    "minX" : 588,
    "maxX" : 2703,
    "minY" : 235,
    "maxY" : 1227,
    "prop" : {
      "x" : 588,
      "y" : 517,
      "width" : 722,
      "height" : 613
    },
    "points" : [ {
      "x" : 588,
      "y" : 235
    }, {
      "x" : 2703,
      "y" : 235
    }, {
      "x" : 2703,
      "y" : 1227
    }, {
      "x" : 588,
      "y" : 1227
    } ],
    "colour" : "#666666"
  }, {
    "id" : 93716,
    "reactomeId" : 10649464,
    "displayName" : "GRB2 events in ERBB2 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1820,
      "y" : 991
    },
    "minX" : 1310,
    "maxX" : 2330,
    "minY" : 852,
    "maxY" : 1130,
    "prop" : {
      "x" : 1310,
      "y" : 852,
      "width" : 378,
      "height" : 276
    },
    "points" : [ {
      "x" : 1310,
      "y" : 852
    }, {
      "x" : 2330,
      "y" : 852
    }, {
      "x" : 2330,
      "y" : 1130
    }, {
      "x" : 1310,
      "y" : 1130
    } ],
    "colour" : "#008000"
  }, {
    "id" : 93719,
    "reactomeId" : 10650228,
    "displayName" : "ERBB2 Activates PTK6 Signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1845,
      "y" : 542
    },
    "minX" : 1589,
    "maxX" : 2102,
    "minY" : 265,
    "maxY" : 820,
    "prop" : {
      "x" : 1589,
      "y" : 637,
      "width" : 513,
      "height" : 183
    },
    "points" : [ {
      "x" : 1589,
      "y" : 265
    }, {
      "x" : 2102,
      "y" : 265
    }, {
      "x" : 2102,
      "y" : 820
    }, {
      "x" : 1589,
      "y" : 820
    } ],
    "colour" : "#cb4ac5"
  }, {
    "id" : 93718,
    "reactomeId" : 10650140,
    "displayName" : "ERBB2 Regulates Cell Motility",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1787,
      "y" : 451
    },
    "minX" : 1589,
    "maxX" : 1985,
    "minY" : 265,
    "maxY" : 637,
    "prop" : {
      "x" : 1589,
      "y" : 265,
      "width" : 396,
      "height" : 372
    },
    "points" : [ {
      "x" : 1589,
      "y" : 265
    }, {
      "x" : 1985,
      "y" : 265
    }, {
      "x" : 1985,
      "y" : 637
    }, {
      "x" : 1589,
      "y" : 637
    } ],
    "colour" : "#4942cc"
  }, {
    "id" : 93720,
    "reactomeId" : 10650556,
    "displayName" : "Drug-mediated inhibition of ERBB2 signaling",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 647,
      "y" : 333
    },
    "minX" : 476,
    "maxX" : 818,
    "minY" : 149,
    "maxY" : 517,
    "prop" : {
      "x" : 476,
      "y" : 149,
      "width" : 342,
      "height" : 86
    },
    "points" : [ {
      "x" : 476,
      "y" : 149
    }, {
      "x" : 818,
      "y" : 149
    }, {
      "x" : 818,
      "y" : 517
    }, {
      "x" : 476,
      "y" : 517
    } ],
    "colour" : "#d6ae00"
  } ],
  "minX" : 0,
  "maxX" : 3089,
  "minY" : 0,
  "maxY" : 1323,
  "disease" : false
}