{ "dbId" : 10913478, "stableId" : "R-DME-9958825", "displayName" : "Activation of STAT3 by cadherin engagement", "nodes" : [ { "id" : 38145, "reactomeId" : 10909235, "displayName" : "F-actin (all)", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 668, "y" : 1030 }, "minX" : 430, "maxX" : 699, "minY" : 1015, "maxY" : 1046, "prop" : { "x" : 637, "y" : 1015, "width" : 62, "height" : 31 }, "textPosition" : { "x" : 641, "y" : 1013 }, "connectors" : [ { "edgeId" : 38144, "type" : "INPUT", "segments" : [ { "from" : { "x" : 634, "y" : 1029 }, "to" : { "x" : 430, "y" : 1025 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 526, "y" : 1021 }, "b" : { "x" : 538, "y" : 1033 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 532, "y" : 1027 } } } } ] }, { "id" : 38146, "reactomeId" : 10909597, "displayName" : "Homotypic CDH1 cis-cluster:F-actin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 400, "y" : 936 }, "minX" : 339, "maxX" : 467, "minY" : 869, "maxY" : 955, "prop" : { "x" : 339, "y" : 917, "width" : 122, "height" : 38 }, "textPosition" : { "x" : 341, "y" : 920 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 461, "y" : 917 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 461, "y" : 917 } } }, "connectors" : [ { "edgeId" : 38144, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38147, "type" : "INPUT", "segments" : [ { "from" : { "x" : 409, "y" : 914 }, "to" : { "x" : 434, "y" : 869 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38148, "reactomeId" : 10853835, "displayName" : "Vinc", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 648, "y" : 941 }, "minX" : 434, "maxX" : 671, "minY" : 869, "maxY" : 950, "prop" : { "x" : 631, "y" : 932, "width" : 34, "height" : 18 }, "textPosition" : { "x" : 631, "y" : 931 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 665, "y" : 932 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 665, "y" : 932 } } }, "connectors" : [ { "edgeId" : 38147, "type" : "INPUT", "segments" : [ { "from" : { "x" : 628, "y" : 935 }, "to" : { "x" : 434, "y" : 869 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 525, "y" : 896 }, "b" : { "x" : 537, "y" : 908 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 531, "y" : 902 } } } } ] }, { "id" : 38180, "reactomeId" : 10913372, "displayName" : "Regulation of CDH1 Expression and Function", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 706, "y" : 1265 }, "minX" : 619, "maxX" : 794, "minY" : 1236, "maxY" : 1295, "prop" : { "x" : 619, "y" : 1236, "width" : 175, "height" : 59 }, "textPosition" : { "x" : 621, "y" : 1244 }, "connectors" : [ ] }, { "id" : 38150, "reactomeId" : 10829864, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 827, "y" : 513 }, "minX" : 770, "maxX" : 846, "minY" : 502, "maxY" : 525, "prop" : { "x" : 808, "y" : 502, "width" : 38, "height" : 23 }, "textPosition" : { "x" : 814, "y" : 503 }, "connectors" : [ { "edgeId" : 38149, "type" : "INPUT", "segments" : [ { "from" : { "x" : 802, "y" : 516 }, "to" : { "x" : 770, "y" : 522 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 780, "y" : 513 }, "b" : { "x" : 792, "y" : 525 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 786, "y" : 519 } } } } ] }, { "id" : 38151, "reactomeId" : 10910276, "displayName" : "Ub-RAC1:GTP,(Ub-CDC42:GTP)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 554, "y" : 233 }, "minX" : 503, "maxX" : 605, "minY" : 215, "maxY" : 251, "prop" : { "x" : 503, "y" : 215, "width" : 102, "height" : 36 }, "textPosition" : { "x" : 507, "y" : 209 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 38149, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38152, "reactomeId" : 10910282, "displayName" : "RAC1,(CDC42) Ubiquitin Ligase", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 663, "y" : 365 }, "minX" : 583, "maxX" : 701, "minY" : 333, "maxY" : 397, "prop" : { "x" : 626, "y" : 333, "width" : 75, "height" : 64 }, "textPosition" : { "x" : 630, "y" : 333 }, "connectors" : [ { "edgeId" : 38149, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 620, "y" : 371 }, "to" : { "x" : 591, "y" : 378 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 587, "y" : 378 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 587, "y" : 378 } } } ] }, { "id" : 38184, "reactomeId" : 10910293, "displayName" : "Homotypic CDH11 trans dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 355, "y" : 428 }, "minX" : 284, "maxX" : 433, "minY" : 405, "maxY" : 445, "prop" : { "x" : 284, "y" : 411, "width" : 143, "height" : 34 }, "textPosition" : { "x" : 294, "y" : 410 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 427, "y" : 411 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 427, "y" : 411 } } }, "connectors" : [ ] }, { "id" : 38153, "reactomeId" : 10910295, "displayName" : "Engaged CDH1,(CDH11)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 371, "y" : 358 }, "minX" : 272, "maxX" : 566, "minY" : 347, "maxY" : 384, "prop" : { "x" : 272, "y" : 347, "width" : 198, "height" : 23 }, "textPosition" : { "x" : 292, "y" : 348 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 38149, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 476, "y" : 369 }, "to" : { "x" : 566, "y" : 380 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 566, "y" : 384 }, "b" : { "x" : 566, "y" : 376 }, "c" : { "x" : 566, "y" : 380 }, "type" : "STOP", "centre" : { "x" : 566, "y" : 380 } } } ] }, { "id" : 38155, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 664, "y" : 813 }, "minX" : 644, "maxX" : 714, "minY" : 800, "maxY" : 863, "prop" : { "x" : 644, "y" : 801, "width" : 40, "height" : 25 }, "textPosition" : { "x" : 648, "y" : 803 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 679, "y" : 806 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 679, "y" : 806 } } }, "connectors" : [ { "edgeId" : 38154, "type" : "INPUT", "segments" : [ { "from" : { "x" : 676, "y" : 829 }, "to" : { "x" : 714, "y" : 863 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38156, "reactomeId" : 10910336, "displayName" : "RAC1:GDP,(CDC42:GDP)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 614, "y" : 866 }, "minX" : 573, "maxX" : 714, "minY" : 851, "maxY" : 882, "prop" : { "x" : 573, "y" : 851, "width" : 83, "height" : 31 }, "textPosition" : { "x" : 577, "y" : 842 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 38154, "type" : "INPUT", "segments" : [ { "from" : { "x" : 662, "y" : 864 }, "to" : { "x" : 714, "y" : 863 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38157, "reactomeId" : 29420, "displayName" : "GDP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 795, "y" : 684 }, "minX" : 717, "maxX" : 812, "minY" : 674, "maxY" : 782, "prop" : { "x" : 779, "y" : 675, "width" : 32, "height" : 19 }, "textPosition" : { "x" : 782, "y" : 667 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 806, "y" : 680 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 806, "y" : 680 } } }, "connectors" : [ { "edgeId" : 38154, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 787, "y" : 697 }, "to" : { "x" : 717, "y" : 782 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 786, "y" : 705 }, "b" : { "x" : 787, "y" : 697 }, "c" : { "x" : 780, "y" : 700 }, "type" : "ARROW", "centre" : { "x" : 780, "y" : 700 } } } ] }, { "id" : 38158, "reactomeId" : 10910324, "displayName" : "SRC-phosphorylated RAC1/CDC42 GEFs", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 741, "y" : 950 }, "minX" : 688, "maxX" : 794, "minY" : 812, "maxY" : 980, "prop" : { "x" : 688, "y" : 921, "width" : 106, "height" : 59 }, "textPosition" : { "x" : 686, "y" : 919 }, "connectors" : [ { "edgeId" : 38154, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 736, "y" : 915 }, "to" : { "x" : 720, "y" : 820 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 719, "y" : 816 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 719, "y" : 816 } } } ] }, { "id" : 38196, "reactomeId" : 10912264, "displayName" : "Interleukin-6 family signaling", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1049, "y" : 228 }, "minX" : 963, "maxX" : 1136, "minY" : 192, "maxY" : 264, "prop" : { "x" : 963, "y" : 192, "width" : 173, "height" : 72 }, "textPosition" : { "x" : 981, "y" : 206 }, "connectors" : [ ] }, { "id" : 38133, "reactomeId" : 10839464, "displayName" : "NFKB1(1-433), NFKB2(1-454):RELA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 790, "y" : 461 }, "minX" : 727, "maxX" : 860, "minY" : 442, "maxY" : 475, "prop" : { "x" : 727, "y" : 448, "width" : 127, "height" : 27 }, "textPosition" : { "x" : 727, "y" : 440 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 854, "y" : 448 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 854, "y" : 448 } } }, "connectors" : [ { "edgeId" : 38132, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38134, "reactomeId" : 10839541, "displayName" : "NFKB1(1-433), NFKB2(1-454):RELA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1026, "y" : 468 }, "minX" : 962, "maxX" : 1096, "minY" : 450, "maxY" : 481, "prop" : { "x" : 962, "y" : 456, "width" : 128, "height" : 25 }, "textPosition" : { "x" : 962, "y" : 446 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1090, "y" : 456 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1090, "y" : 456 } } }, "connectors" : [ { "edgeId" : 38132, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38135, "reactomeId" : 10910261, "displayName" : "RAC1:GTP,(CDC42:GTP)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 602, "y" : 707 }, "minX" : 557, "maxX" : 900, "minY" : 477, "maxY" : 782, "prop" : { "x" : 557, "y" : 692, "width" : 90, "height" : 31 }, "textPosition" : { "x" : 558, "y" : 690 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 38132, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 653, "y" : 694 }, "to" : { "x" : 802, "y" : 652 } }, { "from" : { "x" : 802, "y" : 652 }, "to" : { "x" : 900, "y" : 477 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 900, "y" : 485 }, "b" : { "x" : 900, "y" : 477 }, "c" : { "x" : 893, "y" : 481 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 893, "y" : 481 } } }, { "edgeId" : 38149, "type" : "INPUT", "segments" : [ { "from" : { "x" : 632, "y" : 686 }, "to" : { "x" : 769, "y" : 622 } }, { "from" : { "x" : 769, "y" : 622 }, "to" : { "x" : 770, "y" : 522 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38154, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 625, "y" : 729 }, "to" : { "x" : 717, "y" : 782 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 633, "y" : 729 }, "b" : { "x" : 625, "y" : 729 }, "c" : { "x" : 629, "y" : 736 }, "type" : "ARROW", "centre" : { "x" : 629, "y" : 736 } } } ] }, { "id" : 38137, "reactomeId" : 74112, "displayName" : "Ca2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 343, "y" : 832 }, "minX" : 323, "maxX" : 364, "minY" : 726, "maxY" : 848, "prop" : { "x" : 323, "y" : 817, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 327, "y" : 815 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 358, "y" : 822 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 358, "y" : 822 } } }, "connectors" : [ { "edgeId" : 38136, "type" : "INPUT", "segments" : [ { "from" : { "x" : 341, "y" : 814 }, "to" : { "x" : 333, "y" : 726 } } ], "stoichiometry" : { "value" : 120, "shape" : { "a" : { "x" : 330, "y" : 763 }, "b" : { "x" : 345, "y" : 778 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 337, "y" : 770 } } } } ] }, { "id" : 38138, "reactomeId" : 10909603, "displayName" : "trans-homotypic CDH1 cluster:F-actin:VCL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 243, "y" : 778 }, "minX" : 168, "maxX" : 333, "minY" : 726, "maxY" : 797, "prop" : { "x" : 168, "y" : 759, "width" : 150, "height" : 38 }, "textPosition" : { "x" : 168, "y" : 762 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 318, "y" : 759 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 318, "y" : 759 } } }, "connectors" : [ { "edgeId" : 38136, "type" : "INPUT", "segments" : [ { "from" : { "x" : 275, "y" : 756 }, "to" : { "x" : 333, "y" : 726 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38139, "reactomeId" : 10909599, "displayName" : "Homotypic CDH1 cis-cluster:F-actin:VCL", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 427, "y" : 763 }, "minX" : 333, "maxX" : 507, "minY" : 726, "maxY" : 783, "prop" : { "x" : 354, "y" : 743, "width" : 147, "height" : 40 }, "textPosition" : { "x" : 359, "y" : 748 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 501, "y" : 743 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 501, "y" : 743 } } }, "connectors" : [ { "edgeId" : 38147, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38136, "type" : "INPUT", "segments" : [ { "from" : { "x" : 376, "y" : 740 }, "to" : { "x" : 333, "y" : 726 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38140, "reactomeId" : 10909609, "displayName" : "Homotypic CDH1 trans-dimer cluster", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 343, "y" : 631 }, "minX" : 270, "maxX" : 422, "minY" : 606, "maxY" : 650, "prop" : { "x" : 270, "y" : 612, "width" : 146, "height" : 38 }, "textPosition" : { "x" : 279, "y" : 615 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 416, "y" : 612 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 416, "y" : 612 } } }, "connectors" : [ { "edgeId" : 38136, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 38142, "reactomeId" : 10909593, "displayName" : "Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 439, "y" : 1254 }, "minX" : 352, "maxX" : 526, "minY" : 1187, "maxY" : 1283, "prop" : { "x" : 352, "y" : 1225, "width" : 174, "height" : 58 }, "textPosition" : { "x" : 355, "y" : 1229 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 38141, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 497, "y" : 1187 }, "b" : { "x" : 509, "y" : 1199 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 503, "y" : 1193 } } } } ] }, { "id" : 38143, "reactomeId" : 10909595, "displayName" : "Homotypic CDH1 cis-cluster", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 397, "y" : 1098 }, "minX" : 338, "maxX" : 462, "minY" : 1025, "maxY" : 1115, "prop" : { "x" : 338, "y" : 1082, "width" : 118, "height" : 33 }, "textPosition" : { "x" : 339, "y" : 1080 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 456, "y" : 1082 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 456, "y" : 1082 } } }, "connectors" : [ { "edgeId" : 38144, "type" : "INPUT", "segments" : [ { "from" : { "x" : 404, "y" : 1079 }, "to" : { "x" : 430, "y" : 1025 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 38141, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 38144, "reactomeId" : 10909615, "displayName" : "CDH1-associated CTNNA1 binds F-actin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 419, "y" : 995 }, "minX" : 406, "maxX" : 430, "minY" : 958, "maxY" : 1025, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 430, "y" : 1025 }, "to" : { "x" : 419, "y" : 995 } }, { "from" : { "x" : 419, "y" : 995 }, "to" : { "x" : 406, "y" : 958 } } ], "endShape" : { "a" : { "x" : 412, "y" : 963 }, "b" : { "x" : 406, "y" : 958 }, "c" : { "x" : 405, "y" : 966 }, "type" : "ARROW", "centre" : { "x" : 405, "y" : 966 } }, "reactionShape" : { "c" : { "x" : 419, "y" : 995 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 419, "y" : 995 } }, "inputs" : [ { "id" : 38143, "points" : [ { "x" : 404, "y" : 1079 } ] }, { "id" : 38145, "points" : [ { "x" : 634, "y" : 1029 } ], "stoichiometry" : 5 } ], "outputs" : [ { "id" : 38146 } ] }, { "id" : 38147, "reactomeId" : 10909601, "displayName" : "CDH1-associated CTNNA1 binds VCL", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 432, "y" : 851 }, "minX" : 426, "maxX" : 438, "minY" : 786, "maxY" : 869, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 434, "y" : 869 }, "to" : { "x" : 432, "y" : 851 } }, { "from" : { "x" : 432, "y" : 851 }, "to" : { "x" : 428, "y" : 786 } } ], "endShape" : { "a" : { "x" : 432, "y" : 793 }, "b" : { "x" : 428, "y" : 786 }, "c" : { "x" : 424, "y" : 793 }, "type" : "ARROW", "centre" : { "x" : 424, "y" : 793 } }, "reactionShape" : { "c" : { "x" : 432, "y" : 851 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 432, "y" : 851 } }, "inputs" : [ { "id" : 38148, "points" : [ { "x" : 628, "y" : 935 } ], "stoichiometry" : 5 }, { "id" : 38146, "points" : [ { "x" : 409, "y" : 914 } ] } ], "outputs" : [ { "id" : 38139 } ] }, { "id" : 38132, "reactomeId" : 10910263, "displayName" : "RAC1, CDC42 activate NFκB", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 904, "y" : 469 }, "minX" : 857, "maxX" : 959, "minY" : 463, "maxY" : 475, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 857, "y" : 465 }, "to" : { "x" : 904, "y" : 469 } }, { "from" : { "x" : 904, "y" : 469 }, "to" : { "x" : 959, "y" : 468 } } ], "endShape" : { "a" : { "x" : 952, "y" : 472 }, "b" : { "x" : 959, "y" : 468 }, "c" : { "x" : 952, "y" : 464 }, "type" : "ARROW", "centre" : { "x" : 952, "y" : 464 } }, "reactionShape" : { "a" : { "x" : 898, "y" : 463 }, "b" : { "x" : 910, "y" : 475 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 904, "y" : 469 } }, "inputs" : [ { "id" : 38133 } ], "outputs" : [ { "id" : 38134 } ], "activators" : [ { "id" : 38135, "points" : [ { "x" : 653, "y" : 694 }, { "x" : 802, "y" : 652 } ] } ] }, { "id" : 38149, "reactomeId" : 10910297, "displayName" : "Cell-to-cell contact through homophilic cadherin interactions inhibits RAC1/CDC42 ubiquitination", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 575, "y" : 381 }, "minX" : 556, "maxX" : 770, "minY" : 257, "maxY" : 522, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 770, "y" : 522 }, "to" : { "x" : 577, "y" : 514 } }, { "from" : { "x" : 577, "y" : 514 }, "to" : { "x" : 575, "y" : 381 } }, { "from" : { "x" : 575, "y" : 381 }, "to" : { "x" : 556, "y" : 257 } } ], "endShape" : { "a" : { "x" : 561, "y" : 263 }, "b" : { "x" : 556, "y" : 257 }, "c" : { "x" : 553, "y" : 264 }, "type" : "ARROW", "centre" : { "x" : 553, "y" : 264 } }, "reactionShape" : { "a" : { "x" : 569, "y" : 375 }, "b" : { "x" : 581, "y" : 387 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 575, "y" : 381 } }, "inputs" : [ { "id" : 38135, "points" : [ { "x" : 632, "y" : 686 }, { "x" : 769, "y" : 622 } ] }, { "id" : 38150, "points" : [ { "x" : 802, "y" : 516 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 38151 } ], "catalysts" : [ { "id" : 38152, "points" : [ { "x" : 620, "y" : 371 } ] } ], "inhibitors" : [ { "id" : 38153, "points" : [ { "x" : 476, "y" : 369 } ] } ] }, { "id" : 38136, "reactomeId" : 10909611, "displayName" : "CDH1 forms homotypic trans-dimers", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 337, "y" : 694 }, "minX" : 331, "maxX" : 343, "minY" : 653, "maxY" : 726, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 333, "y" : 726 }, "to" : { "x" : 337, "y" : 694 } }, { "from" : { "x" : 337, "y" : 694 }, "to" : { "x" : 341, "y" : 653 } } ], "endShape" : { "a" : { "x" : 344, "y" : 660 }, "b" : { "x" : 341, "y" : 653 }, "c" : { "x" : 336, "y" : 660 }, "type" : "ARROW", "centre" : { "x" : 336, "y" : 660 } }, "reactionShape" : { "c" : { "x" : 337, "y" : 694 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 337, "y" : 694 } }, "inputs" : [ { "id" : 38137, "points" : [ { "x" : 341, "y" : 814 } ], "stoichiometry" : 120 }, { "id" : 38138, "points" : [ { "x" : 275, "y" : 756 } ] }, { "id" : 38139, "points" : [ { "x" : 376, "y" : 740 } ] } ], "outputs" : [ { "id" : 38140 } ] }, { "id" : 38154, "reactomeId" : 10910339, "displayName" : "SRC-phosphorylated RAC1,(CDC42) GEFs activate RAC1,(CDC42)", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 717, "y" : 804 }, "minX" : 711, "maxX" : 723, "minY" : 782, "maxY" : 863, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 714, "y" : 863 }, "to" : { "x" : 717, "y" : 804 } }, { "from" : { "x" : 717, "y" : 804 }, "to" : { "x" : 717, "y" : 782 } } ], "reactionShape" : { "a" : { "x" : 711, "y" : 798 }, "b" : { "x" : 723, "y" : 810 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 717, "y" : 804 } }, "inputs" : [ { "id" : 38155, "points" : [ { "x" : 676, "y" : 829 } ] }, { "id" : 38156, "points" : [ { "x" : 662, "y" : 864 } ] } ], "outputs" : [ { "id" : 38135, "points" : [ { "x" : 625, "y" : 729 } ] }, { "id" : 38157, "points" : [ { "x" : 787, "y" : 697 } ] } ], "catalysts" : [ { "id" : 38158, "points" : [ { "x" : 736, "y" : 915 } ] } ] }, { "id" : 38141, "reactomeId" : 10909613, "displayName" : "CDH1 forms cis-clusters", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 535, "y" : 1168 }, "minX" : 429, "maxX" : 541, "minY" : 1118, "maxY" : 1219, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 471, "y" : 1219 }, "to" : { "x" : 535, "y" : 1168 } }, { "from" : { "x" : 535, "y" : 1168 }, "to" : { "x" : 429, "y" : 1118 } } ], "endShape" : { "a" : { "x" : 437, "y" : 1117 }, "b" : { "x" : 429, "y" : 1118 }, "c" : { "x" : 434, "y" : 1125 }, "type" : "ARROW", "centre" : { "x" : 434, "y" : 1125 } }, "reactionShape" : { "c" : { "x" : 535, "y" : 1168 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 535, "y" : 1168 } }, "inputs" : [ { "id" : 38142, "stoichiometry" : 5 } ], "outputs" : [ { "id" : 38143 } ] } ], "compartments" : [ { "id" : 38178, "reactomeId" : 171043, "displayName" : "early endosome lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 806, "y" : 1777 }, "minX" : 684, "maxX" : 929, "minY" : 1719, "maxY" : 1836, "prop" : { "x" : 684, "y" : 1719, "width" : 245, "height" : 117 }, "textPosition" : { "x" : 725, "y" : 1785 }, "insets" : { "x" : 694, "y" : 1729, "width" : 225, "height" : 97 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 38179, "reactomeId" : 161320, "displayName" : "lysosomal lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 939, "y" : 1589 }, "minX" : 845, "maxX" : 1034, "minY" : 1485, "maxY" : 1693, "prop" : { "x" : 845, "y" : 1485, "width" : 189, "height" : 208 }, "textPosition" : { "x" : 865, "y" : 1638 }, "insets" : { "x" : 855, "y" : 1495, "width" : 169, "height" : 188 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 38181, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 154, "y" : 960 }, "minX" : 0, "maxX" : 308, "minY" : 1, "maxY" : 1919, "prop" : { "x" : 0, "y" : 1, "width" : 308, "height" : 1918 }, "textPosition" : { "x" : 13, "y" : 1865 }, "insets" : { "x" : 10, "y" : 11, "width" : 288, "height" : 1898 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 38138, 38140, 38184, 38153 ] }, { "id" : 38170, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1038, "y" : 496 }, "minX" : 896, "maxX" : 1180, "minY" : 312, "maxY" : 681, "prop" : { "x" : 896, "y" : 312, "width" : 284, "height" : 369 }, "textPosition" : { "x" : 914, "y" : 631 }, "insets" : { "x" : 906, "y" : 322, "width" : 264, "height" : 349 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 38134, 38132 ] }, { "id" : 38159, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1269, "y" : 955 }, "minX" : 385, "maxX" : 2153, "minY" : 0, "maxY" : 1911, "prop" : { "x" : 385, "y" : 0, "width" : 1768, "height" : 1911 }, "textPosition" : { "x" : 603, "y" : 1851 }, "insets" : { "x" : 395, "y" : 10, "width" : 1748, "height" : 1891 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 38199, 38198, 38170, 38178, 38179, 38142, 38133, 38135, 38139, 38141, 38143, 38144, 38145, 38146, 38147, 38148, 38180, 38200, 38156, 38201, 38151, 38152, 38158, 38149, 38193, 38157, 38155, 38154, 38150, 38196, 38203 ] } ], "notes" : [ { "id" : 38193, "displayName" : "Downregulation", "renderableClass" : "Note", "position" : { "x" : 887, "y" : 238 }, "minX" : 834, "maxX" : 940, "minY" : 224, "maxY" : 253, "prop" : { "x" : 834, "y" : 224, "width" : 106, "height" : 29 }, "textPosition" : { "x" : 834, "y" : 228 } } ], "links" : [ { "id" : 38200, "renderableClass" : "Interaction", "position" : { "x" : 574, "y" : 1258 }, "minX" : 532, "maxX" : 616, "minY" : 1252, "maxY" : 1264, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 616, "y" : 1260 }, "to" : { "x" : 532, "y" : 1256 } } ], "endShape" : { "a" : { "x" : 539, "y" : 1252 }, "b" : { "x" : 532, "y" : 1256 }, "c" : { "x" : 539, "y" : 1260 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 539, "y" : 1260 } }, "reactionShape" : { "a" : { "x" : 568, "y" : 1252 }, "b" : { "x" : 580, "y" : 1264 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 574, "y" : 1258 } }, "inputs" : [ { "id" : 38180 } ], "outputs" : [ { "id" : 38142 } ] }, { "id" : 38201, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 559, "y" : 532 }, "minX" : 397, "maxX" : 565, "minY" : 376, "maxY" : 628, "segments" : [ { "from" : { "x" : 419, "y" : 628 }, "to" : { "x" : 557, "y" : 623 } }, { "from" : { "x" : 557, "y" : 623 }, "to" : { "x" : 562, "y" : 441 } }, { "from" : { "x" : 562, "y" : 441 }, "to" : { "x" : 397, "y" : 376 } } ], "reactionShape" : { "a" : { "x" : 553, "y" : 526 }, "b" : { "x" : 565, "y" : 538 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 559, "y" : 532 } }, "inputs" : [ { "id" : 38140 } ], "outputs" : [ { "id" : 38153 } ] }, { "id" : 38202, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 363, "y" : 392 }, "minX" : 357, "maxX" : 369, "minY" : 376, "maxY" : 408, "segments" : [ { "from" : { "x" : 359, "y" : 408 }, "to" : { "x" : 368, "y" : 376 } } ], "reactionShape" : { "a" : { "x" : 357, "y" : 386 }, "b" : { "x" : 369, "y" : 398 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 363, "y" : 392 } }, "inputs" : [ { "id" : 38184 } ], "outputs" : [ { "id" : 38153 } ] } ], "shadows" : [ { "id" : 38203, "reactomeId" : 10913506, "displayName" : "SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST)", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 684, "y" : 827 }, "minX" : 547, "maxX" : 821, "minY" : 665, "maxY" : 990, "prop" : { "x" : 547, "y" : 665, "width" : 274, "height" : 325 }, "points" : [ { "x" : 547, "y" : 665 }, { "x" : 821, "y" : 665 }, { "x" : 821, "y" : 990 }, { "x" : 547, "y" : 990 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 2153, "minY" : 0, "maxY" : 1919, "disease" : false }