{ "dbId" : 10912064, "stableId" : "R-DME-917937", "displayName" : "Iron uptake and transport", "nodes" : [ { "id" : 80256, "reactomeId" : 10833778, "displayName" : "V-ATPase:ATP6AP1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 823, "y" : 769 }, "minX" : 761, "maxX" : 892, "minY" : 752, "maxY" : 852, "prop" : { "x" : 761, "y" : 758, "width" : 125, "height" : 22 }, "textPosition" : { "x" : 761, "y" : 759 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 886, "y" : 758 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 886, "y" : 758 } } }, "connectors" : [ { "edgeId" : 80257, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 822, "y" : 783 }, "to" : { "x" : 822, "y" : 844 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 822, "y" : 848 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 822, "y" : 848 } } }, { "edgeId" : 80253, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80259, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 883, "y" : 814 }, "minX" : 858, "maxX" : 906, "minY" : 798, "maxY" : 860, "prop" : { "x" : 862, "y" : 799, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 866, "y" : 803 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 900, "y" : 804 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 900, "y" : 804 } } }, "connectors" : [ { "edgeId" : 80257, "type" : "INPUT", "segments" : [ { "from" : { "x" : 874, "y" : 832 }, "to" : { "x" : 858, "y" : 860 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 80258, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 923, "y" : 841 }, "minX" : 858, "maxX" : 944, "minY" : 825, "maxY" : 860, "prop" : { "x" : 903, "y" : 826, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 907, "y" : 830 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 938, "y" : 831 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 938, "y" : 831 } } }, "connectors" : [ { "edgeId" : 80257, "type" : "INPUT", "segments" : [ { "from" : { "x" : 900, "y" : 846 }, "to" : { "x" : 858, "y" : 860 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80261, "reactomeId" : 74722, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 731, "y" : 722 }, "minX" : 713, "maxX" : 750, "minY" : 706, "maxY" : 860, "prop" : { "x" : 713, "y" : 707, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 717, "y" : 711 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 744, "y" : 712 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 744, "y" : 712 } } }, "connectors" : [ { "edgeId" : 80257, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 731, "y" : 740 }, "to" : { "x" : 736, "y" : 860 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 727, "y" : 794 }, "b" : { "x" : 739, "y" : 806 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 733, "y" : 800 } } }, "endShape" : { "a" : { "x" : 735, "y" : 747 }, "b" : { "x" : 731, "y" : 740 }, "c" : { "x" : 727, "y" : 747 }, "type" : "ARROW", "centre" : { "x" : 727, "y" : 747 } } } ], "trivial" : true }, { "id" : 80260, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 913, "y" : 885 }, "minX" : 858, "maxX" : 932, "minY" : 860, "maxY" : 900, "prop" : { "x" : 895, "y" : 870, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 899, "y" : 874 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 926, "y" : 875 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 926, "y" : 875 } } }, "connectors" : [ { "edgeId" : 80257, "type" : "INPUT", "segments" : [ { "from" : { "x" : 892, "y" : 876 }, "to" : { "x" : 858, "y" : 860 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 869, "y" : 862 }, "b" : { "x" : 881, "y" : 874 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 875, "y" : 868 } } } } ], "trivial" : true }, { "id" : 80263, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 679, "y" : 880 }, "minX" : 666, "maxX" : 736, "minY" : 860, "maxY" : 895, "prop" : { "x" : 666, "y" : 865, "width" : 27, "height" : 30 }, "textPosition" : { "x" : 670, "y" : 869 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 688, "y" : 870 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 688, "y" : 870 } } }, "connectors" : [ { "edgeId" : 80257, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 696, "y" : 875 }, "to" : { "x" : 736, "y" : 860 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 701, "y" : 869 }, "b" : { "x" : 696, "y" : 875 }, "c" : { "x" : 704, "y" : 876 }, "type" : "ARROW", "centre" : { "x" : 704, "y" : 876 } } } ] }, { "id" : 80262, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 670, "y" : 835 }, "minX" : 650, "maxX" : 736, "minY" : 819, "maxY" : 860, "prop" : { "x" : 650, "y" : 820, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 654, "y" : 824 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 686, "y" : 825 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 686, "y" : 825 } } }, "connectors" : [ { "edgeId" : 80257, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 694, "y" : 842 }, "to" : { "x" : 736, "y" : 860 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 702, "y" : 841 }, "b" : { "x" : 694, "y" : 842 }, "c" : { "x" : 699, "y" : 848 }, "type" : "ARROW", "centre" : { "x" : 699, "y" : 848 } } } ] }, { "id" : 80265, "reactomeId" : 917810, "displayName" : "Fe2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1078, "y" : 614 }, "minX" : 1054, "maxX" : 1103, "minY" : 598, "maxY" : 629, "prop" : { "x" : 1054, "y" : 599, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 1057, "y" : 603 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1097, "y" : 604 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1097, "y" : 604 } } }, "connectors" : [ { "edgeId" : 80264, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80266, "reactomeId" : 10858263, "displayName" : "Trpml", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 614, "y" : 666 }, "minX" : 585, "maxX" : 650, "minY" : 624, "maxY" : 677, "prop" : { "x" : 585, "y" : 655, "width" : 59, "height" : 22 }, "textPosition" : { "x" : 593, "y" : 655 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 644, "y" : 655 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 644, "y" : 655 } } }, "connectors" : [ { "edgeId" : 80264, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 614, "y" : 652 }, "to" : { "x" : 614, "y" : 632 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 614, "y" : 628 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 614, "y" : 628 } } } ] }, { "id" : 80269, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 479, "y" : 507 }, "minX" : 462, "maxX" : 502, "minY" : 469, "maxY" : 522, "prop" : { "x" : 462, "y" : 492, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 466, "y" : 496 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 491, "y" : 497 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 491, "y" : 497 } } }, "connectors" : [ { "edgeId" : 80267, "type" : "INPUT", "segments" : [ { "from" : { "x" : 488, "y" : 489 }, "to" : { "x" : 502, "y" : 469 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 489, "y" : 473 }, "b" : { "x" : 501, "y" : 485 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 495, "y" : 479 } } } } ], "trivial" : true }, { "id" : 80268, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 477, "y" : 420 }, "minX" : 459, "maxX" : 502, "minY" : 404, "maxY" : 469, "prop" : { "x" : 459, "y" : 405, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 463, "y" : 409 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 490, "y" : 410 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 490, "y" : 410 } } }, "connectors" : [ { "edgeId" : 80267, "type" : "INPUT", "segments" : [ { "from" : { "x" : 484, "y" : 438 }, "to" : { "x" : 502, "y" : 469 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 487, "y" : 447 }, "b" : { "x" : 499, "y" : 459 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 493, "y" : 453 } } } } ], "trivial" : true }, { "id" : 80271, "reactomeId" : 10852940, "displayName" : "Ferritin Complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 569, "y" : 414 }, "minX" : 517, "maxX" : 627, "minY" : 397, "maxY" : 461, "prop" : { "x" : 517, "y" : 403, "width" : 104, "height" : 22 }, "textPosition" : { "x" : 539, "y" : 390 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 621, "y" : 403 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 621, "y" : 403 } } }, "connectors" : [ { "edgeId" : 80267, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 568, "y" : 428 }, "to" : { "x" : 568, "y" : 453 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 568, "y" : 457 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 568, "y" : 457 } } } ] }, { "id" : 80270, "reactomeId" : 5691103, "displayName" : "Fe(3+)O(OH)", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 703, "y" : 470 }, "minX" : 605, "maxX" : 750, "minY" : 454, "maxY" : 485, "prop" : { "x" : 658, "y" : 455, "width" : 91, "height" : 30 }, "textPosition" : { "x" : 659, "y" : 459 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 744, "y" : 460 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 744, "y" : 460 } } }, "connectors" : [ { "edgeId" : 80267, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 605, "y" : 463 }, "b" : { "x" : 617, "y" : 475 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 611, "y" : 469 } } } } ] }, { "id" : 80273, "reactomeId" : 10876647, "displayName" : "LCN2:2,5DHBA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 952, "y" : 252 }, "minX" : 904, "maxX" : 1007, "minY" : 216, "maxY" : 263, "prop" : { "x" : 904, "y" : 241, "width" : 97, "height" : 22 }, "textPosition" : { "x" : 904, "y" : 242 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1001, "y" : 241 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1001, "y" : 241 } } }, "connectors" : [ { "edgeId" : 80272, "type" : "INPUT", "segments" : [ { "from" : { "x" : 958, "y" : 238 }, "to" : { "x" : 973, "y" : 216 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80274, "reactomeId" : 10876649, "displayName" : "LCN2:2,5DHBA:Fe3+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1063, "y" : 215 }, "minX" : 1013, "maxX" : 1120, "minY" : 191, "maxY" : 233, "prop" : { "x" : 1013, "y" : 197, "width" : 101, "height" : 36 }, "textPosition" : { "x" : 1013, "y" : 198 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1114, "y" : 197 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1114, "y" : 197 } } }, "connectors" : [ { "edgeId" : 80272, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80277, "reactomeId" : 10881012, "displayName" : "SLC22A17:LCN2:2,5DHBA", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1280, "y" : 312 }, "minX" : 1206, "maxX" : 1349, "minY" : 288, "maxY" : 375, "prop" : { "x" : 1218, "y" : 294, "width" : 125, "height" : 36 }, "textPosition" : { "x" : 1226, "y" : 295 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1343, "y" : 294 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1343, "y" : 294 } } }, "connectors" : [ { "edgeId" : 80275, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1258, "y" : 333 }, "to" : { "x" : 1206, "y" : 375 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1255, "y" : 340 }, "b" : { "x" : 1258, "y" : 333 }, "c" : { "x" : 1250, "y" : 334 }, "type" : "ARROW", "centre" : { "x" : 1250, "y" : 334 } } } ] }, { "id" : 80276, "reactomeId" : 10881010, "displayName" : "SLC22A17:LCN2:2,5DHBA:Fe3+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1129, "y" : 314 }, "minX" : 1069, "maxX" : 1196, "minY" : 290, "maxY" : 333, "prop" : { "x" : 1069, "y" : 296, "width" : 121, "height" : 37 }, "textPosition" : { "x" : 1075, "y" : 298 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1190, "y" : 296 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1190, "y" : 296 } } }, "connectors" : [ { "edgeId" : 80275, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80279, "reactomeId" : 10881008, "displayName" : "Homologues of SLC22A17", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1013, "y" : 310 }, "minX" : 979, "maxX" : 1124, "minY" : 299, "maxY" : 379, "prop" : { "x" : 979, "y" : 299, "width" : 69, "height" : 22 }, "textPosition" : { "x" : 982, "y" : 279 }, "connectors" : [ { "edgeId" : 80275, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1022, "y" : 324 }, "to" : { "x" : 1069, "y" : 375 } }, { "from" : { "x" : 1069, "y" : 375 }, "to" : { "x" : 1116, "y" : 375 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1120, "y" : 375 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1120, "y" : 375 } } } ] }, { "id" : 80278, "reactomeId" : 111736, "displayName" : "Fe3+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1269, "y" : 412 }, "minX" : 1206, "maxX" : 1294, "minY" : 375, "maxY" : 427, "prop" : { "x" : 1245, "y" : 397, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 1248, "y" : 401 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1288, "y" : 402 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1288, "y" : 402 } } }, "connectors" : [ { "edgeId" : 80275, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1242, "y" : 397 }, "to" : { "x" : 1206, "y" : 375 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1234, "y" : 397 }, "b" : { "x" : 1242, "y" : 397 }, "c" : { "x" : 1238, "y" : 390 }, "type" : "ARROW", "centre" : { "x" : 1238, "y" : 390 } } } ] }, { "id" : 80281, "reactomeId" : 113531, "displayName" : "Fe2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1414, "y" : 1012 }, "minX" : 1390, "maxX" : 1497, "minY" : 996, "maxY" : 1070, "prop" : { "x" : 1390, "y" : 997, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 1393, "y" : 1001 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1433, "y" : 1002 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1433, "y" : 1002 } } }, "connectors" : [ { "edgeId" : 80280, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1435, "y" : 1030 }, "to" : { "x" : 1497, "y" : 1070 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1460, "y" : 1044 }, "b" : { "x" : 1472, "y" : 1056 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1466, "y" : 1050 } } } } ] }, { "id" : 80283, "reactomeId" : 113529, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1410, "y" : 1098 }, "minX" : 1392, "maxX" : 1497, "minY" : 1070, "maxY" : 1113, "prop" : { "x" : 1392, "y" : 1083, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 1396, "y" : 1087 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1423, "y" : 1088 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1423, "y" : 1088 } } }, "connectors" : [ { "edgeId" : 80280, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1431, "y" : 1092 }, "to" : { "x" : 1497, "y" : 1070 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1458, "y" : 1075 }, "b" : { "x" : 1470, "y" : 1087 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1464, "y" : 1081 } } } } ], "trivial" : true }, { "id" : 80282, "reactomeId" : 113533, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1410, "y" : 1058 }, "minX" : 1393, "maxX" : 1497, "minY" : 1042, "maxY" : 1073, "prop" : { "x" : 1393, "y" : 1043, "width" : 34, "height" : 30 }, "textPosition" : { "x" : 1397, "y" : 1047 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1422, "y" : 1048 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1422, "y" : 1048 } } }, "connectors" : [ { "edgeId" : 80280, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1430, "y" : 1060 }, "to" : { "x" : 1497, "y" : 1070 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1457, "y" : 1059 }, "b" : { "x" : 1469, "y" : 1071 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1463, "y" : 1065 } } } } ], "trivial" : true }, { "id" : 80285, "reactomeId" : 10883592, "displayName" : "FTMT 24mer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1539, "y" : 1019 }, "minX" : 1497, "maxX" : 1587, "minY" : 1002, "maxY" : 1062, "prop" : { "x" : 1497, "y" : 1008, "width" : 84, "height" : 22 }, "textPosition" : { "x" : 1497, "y" : 1009 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1581, "y" : 1008 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1581, "y" : 1008 } } }, "connectors" : [ { "edgeId" : 80280, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1539, "y" : 1033 }, "to" : { "x" : 1539, "y" : 1054 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1539, "y" : 1058 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1539, "y" : 1058 } } } ] }, { "id" : 80284, "reactomeId" : 5691135, "displayName" : "Fe(3+)O(OH)", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1671, "y" : 1071 }, "minX" : 1575, "maxX" : 1718, "minY" : 1055, "maxY" : 1086, "prop" : { "x" : 1626, "y" : 1056, "width" : 91, "height" : 30 }, "textPosition" : { "x" : 1627, "y" : 1060 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1712, "y" : 1061 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1712, "y" : 1061 } } }, "connectors" : [ { "edgeId" : 80280, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 1575, "y" : 1064 }, "b" : { "x" : 1587, "y" : 1076 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1581, "y" : 1070 } } } } ] }, { "id" : 80287, "reactomeId" : 10883473, "displayName" : "Irp-1B", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 980, "y" : 1035 }, "minX" : 959, "maxX" : 1023, "minY" : 998, "maxY" : 1046, "prop" : { "x" : 959, "y" : 1024, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 966, "y" : 1018 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1001, "y" : 1024 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1001, "y" : 1024 } } }, "connectors" : [ { "edgeId" : 80286, "type" : "INPUT", "segments" : [ { "from" : { "x" : 994, "y" : 1021 }, "to" : { "x" : 1023, "y" : 1002 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 80286, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 979, "y" : 1021 }, "to" : { "x" : 979, "y" : 1002 } }, { "from" : { "x" : 979, "y" : 1002 }, "to" : { "x" : 1008, "y" : 1002 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1012, "y" : 1002 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1012, "y" : 1002 } } } ] }, { "id" : 80289, "reactomeId" : 10883475, "displayName" : "ACO1:4Fe-4S", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1114, "y" : 1003 }, "minX" : 1070, "maxX" : 1164, "minY" : 986, "maxY" : 1014, "prop" : { "x" : 1070, "y" : 992, "width" : 88, "height" : 22 }, "textPosition" : { "x" : 1070, "y" : 993 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1158, "y" : 992 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1158, "y" : 992 } } }, "connectors" : [ { "edgeId" : 80286, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80288, "reactomeId" : 5690881, "displayName" : "4Fe-4S", "schemaClass" : "OtherEntity", "renderableClass" : "Entity", "position" : { "x" : 985, "y" : 958 }, "minX" : 960, "maxX" : 1023, "minY" : 947, "maxY" : 1002, "prop" : { "x" : 960, "y" : 947, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 960, "y" : 947 }, "connectors" : [ { "edgeId" : 80286, "type" : "INPUT", "segments" : [ { "from" : { "x" : 994, "y" : 972 }, "to" : { "x" : 1023, "y" : 1002 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80290, "reactomeId" : 71067, "displayName" : "Fe2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1176, "y" : 1087 }, "minX" : 1032, "maxX" : 1201, "minY" : 1006, "maxY" : 1102, "prop" : { "x" : 1152, "y" : 1072, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 1155, "y" : 1076 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1195, "y" : 1077 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1195, "y" : 1077 } } }, "connectors" : [ { "edgeId" : 80286, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1149, "y" : 1073 }, "to" : { "x" : 1032, "y" : 1006 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1040, "y" : 1006 }, "b" : { "x" : 1032, "y" : 1006 }, "c" : { "x" : 1036, "y" : 1013 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1036, "y" : 1013 } } } ] }, { "id" : 80293, "reactomeId" : 10883617, "displayName" : "Cand1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 406, "y" : 1027 }, "minX" : 358, "maxX" : 438, "minY" : 1010, "maxY" : 1064, "prop" : { "x" : 381, "y" : 1016, "width" : 51, "height" : 22 }, "textPosition" : { "x" : 382, "y" : 1016 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 432, "y" : 1016 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 432, "y" : 1016 } } }, "connectors" : [ { "edgeId" : 80291, "type" : "INPUT", "segments" : [ { "from" : { "x" : 391, "y" : 1041 }, "to" : { "x" : 358, "y" : 1064 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80292, "reactomeId" : 10840274, "displayName" : "Cul1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 411, "y" : 1099 }, "minX" : 358, "maxX" : 437, "minY" : 1064, "maxY" : 1110, "prop" : { "x" : 392, "y" : 1088, "width" : 39, "height" : 22 }, "textPosition" : { "x" : 394, "y" : 1088 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 431, "y" : 1088 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 431, "y" : 1088 } } }, "connectors" : [ { "edgeId" : 80291, "type" : "INPUT", "segments" : [ { "from" : { "x" : 394, "y" : 1085 }, "to" : { "x" : 358, "y" : 1064 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80294, "reactomeId" : 10883619, "displayName" : "CANDI:CUL1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 271, "y" : 1066 }, "minX" : 231, "maxX" : 317, "minY" : 1049, "maxY" : 1077, "prop" : { "x" : 231, "y" : 1055, "width" : 80, "height" : 22 }, "textPosition" : { "x" : 231, "y" : 1056 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 311, "y" : 1055 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 311, "y" : 1055 } } }, "connectors" : [ { "edgeId" : 80291, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80297, "reactomeId" : 10883487, "displayName" : "Homologues of IREB2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 901, "y" : 1034 }, "minX" : 845, "maxX" : 922, "minY" : 1023, "maxY" : 1045, "prop" : { "x" : 880, "y" : 1023, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 883, "y" : 989 }, "connectors" : [ { "edgeId" : 80295, "type" : "INPUT", "segments" : [ { "from" : { "x" : 877, "y" : 1034 }, "to" : { "x" : 845, "y" : 1034 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80296, "reactomeId" : 10829864, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 863, "y" : 981 }, "minX" : 845, "maxX" : 876, "minY" : 970, "maxY" : 1034, "prop" : { "x" : 851, "y" : 970, "width" : 25, "height" : 22 }, "textPosition" : { "x" : 851, "y" : 970 }, "connectors" : [ { "edgeId" : 80295, "type" : "INPUT", "segments" : [ { "from" : { "x" : 859, "y" : 998 }, "to" : { "x" : 845, "y" : 1034 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 846, "y" : 1010 }, "b" : { "x" : 858, "y" : 1022 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 852, "y" : 1016 } } } } ] }, { "id" : 80299, "reactomeId" : 10883609, "displayName" : "SKP1:FBXL5:CUL1:NEDD8", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 812, "y" : 1102 }, "minX" : 755, "maxX" : 876, "minY" : 1042, "maxY" : 1120, "prop" : { "x" : 755, "y" : 1084, "width" : 115, "height" : 36 }, "textPosition" : { "x" : 769, "y" : 1085 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 870, "y" : 1084 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 870, "y" : 1084 } } }, "connectors" : [ { "edgeId" : 80295, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 812, "y" : 1081 }, "to" : { "x" : 813, "y" : 1050 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 813, "y" : 1046 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 813, "y" : 1046 } } } ] }, { "id" : 80298, "reactomeId" : 10883603, "displayName" : "Homologues of Ub-K-IREB2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 727, "y" : 1035 }, "minX" : 687, "maxX" : 767, "minY" : 1024, "maxY" : 1046, "prop" : { "x" : 687, "y" : 1024, "width" : 80, "height" : 22 }, "textPosition" : { "x" : 687, "y" : 1011 }, "connectors" : [ { "edgeId" : 80295, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80315, "reactomeId" : 10883489, "displayName" : "ACO1, IREB2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 974, "y" : 1121 }, "minX" : 933, "maxX" : 1016, "minY" : 1110, "maxY" : 1132, "prop" : { "x" : 933, "y" : 1110, "width" : 83, "height" : 22 }, "textPosition" : { "x" : 950, "y" : 1104 }, "connectors" : [ ] }, { "id" : 80321, "reactomeId" : 10911872, "displayName" : "Metabolism of cofactors", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1254, "y" : 1001 }, "minX" : 1198, "maxX" : 1310, "minY" : 963, "maxY" : 1040, "prop" : { "x" : 1198, "y" : 963, "width" : 112, "height" : 77 }, "textPosition" : { "x" : 1200, "y" : 980 }, "connectors" : [ ] }, { "id" : 80227, "reactomeId" : 917828, "displayName" : "e-", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 299, "y" : 47 }, "minX" : 284, "maxX" : 317, "minY" : 31, "maxY" : 87, "prop" : { "x" : 284, "y" : 32, "width" : 31, "height" : 30 }, "textPosition" : { "x" : 289, "y" : 36 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 310, "y" : 37 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 310, "y" : 37 } } }, "connectors" : [ { "edgeId" : 80225, "type" : "INPUT", "segments" : [ { "from" : { "x" : 305, "y" : 65 }, "to" : { "x" : 317, "y" : 87 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80226, "reactomeId" : 912516, "displayName" : "Fe3+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 898, "y" : 186 }, "minX" : 317, "maxX" : 1476, "minY" : 60, "maxY" : 216, "prop" : { "x" : 874, "y" : 171, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 877, "y" : 175 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 917, "y" : 176 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 917, "y" : 176 } } }, "connectors" : [ { "edgeId" : 80225, "type" : "INPUT", "segments" : [ { "from" : { "x" : 891, "y" : 168 }, "to" : { "x" : 857, "y" : 93 } }, { "from" : { "x" : 857, "y" : 93 }, "to" : { "x" : 317, "y" : 87 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 80235, "type" : "INPUT", "segments" : [ { "from" : { "x" : 925, "y" : 180 }, "to" : { "x" : 1476, "y" : 60 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1194, "y" : 114 }, "b" : { "x" : 1206, "y" : 126 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1200, "y" : 120 } } } }, { "edgeId" : 80272, "type" : "INPUT", "segments" : [ { "from" : { "x" : 925, "y" : 195 }, "to" : { "x" : 973, "y" : 216 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80229, "reactomeId" : 10858238, "displayName" : "CYBRD1:Heme", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 102, "y" : 313 }, "minX" : 55, "maxX" : 309, "minY" : 109, "maxY" : 324, "prop" : { "x" : 55, "y" : 302, "width" : 94, "height" : 22 }, "textPosition" : { "x" : 72, "y" : 289 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 149, "y" : 302 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 149, "y" : 302 } } }, "connectors" : [ { "edgeId" : 80225, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 110, "y" : 299 }, "to" : { "x" : 255, "y" : 112 } }, { "from" : { "x" : 255, "y" : 112 }, "to" : { "x" : 301, "y" : 113 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 305, "y" : 113 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 305, "y" : 113 } } } ] }, { "id" : 80228, "reactomeId" : 435347, "displayName" : "Fe2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 295, "y" : 196 }, "minX" : 249, "maxX" : 320, "minY" : 180, "maxY" : 263, "prop" : { "x" : 271, "y" : 181, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 274, "y" : 185 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 314, "y" : 186 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 314, "y" : 186 } } }, "connectors" : [ { "edgeId" : 80225, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 80230, "type" : "INPUT", "segments" : [ { "from" : { "x" : 284, "y" : 214 }, "to" : { "x" : 249, "y" : 263 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80231, "reactomeId" : 351626, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 242, "y" : 213 }, "minX" : 224, "maxX" : 261, "minY" : 197, "maxY" : 263, "prop" : { "x" : 224, "y" : 198, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 228, "y" : 202 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 255, "y" : 203 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 255, "y" : 203 } } }, "connectors" : [ { "edgeId" : 80230, "type" : "INPUT", "segments" : [ { "from" : { "x" : 244, "y" : 231 }, "to" : { "x" : 249, "y" : 263 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 80233, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 216, "y" : 421 }, "minX" : 198, "maxX" : 249, "minY" : 355, "maxY" : 436, "prop" : { "x" : 198, "y" : 406, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 202, "y" : 410 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 229, "y" : 411 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 229, "y" : 411 } } }, "connectors" : [ { "edgeId" : 80230, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 223, "y" : 403 }, "to" : { "x" : 249, "y" : 355 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 223, "y" : 395 }, "b" : { "x" : 223, "y" : 403 }, "c" : { "x" : 230, "y" : 399 }, "type" : "ARROW", "centre" : { "x" : 230, "y" : 399 } } } ], "trivial" : true }, { "id" : 80232, "reactomeId" : 71067, "displayName" : "Fe2+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 294, "y" : 423 }, "minX" : 249, "maxX" : 502, "minY" : 355, "maxY" : 469, "prop" : { "x" : 270, "y" : 408, "width" : 48, "height" : 30 }, "textPosition" : { "x" : 273, "y" : 412 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 313, "y" : 413 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 313, "y" : 413 } } }, "connectors" : [ { "edgeId" : 80230, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 284, "y" : 405 }, "to" : { "x" : 249, "y" : 355 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 277, "y" : 402 }, "b" : { "x" : 284, "y" : 405 }, "c" : { "x" : 283, "y" : 397 }, "type" : "ARROW", "centre" : { "x" : 283, "y" : 397 } } }, { "edgeId" : 80264, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 80267, "type" : "INPUT", "segments" : [ { "from" : { "x" : 321, "y" : 428 }, "to" : { "x" : 502, "y" : 469 } } ], "stoichiometry" : { "value" : 4, "shape" : { "a" : { "x" : 405, "y" : 442 }, "b" : { "x" : 417, "y" : 454 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 411, "y" : 448 } } } } ] }, { "id" : 80234, "reactomeId" : 10853122, "displayName" : "Mvl", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 188, "y" : 314 }, "minX" : 158, "maxX" : 241, "minY" : 297, "maxY" : 325, "prop" : { "x" : 158, "y" : 303, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 175, "y" : 303 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 219, "y" : 303 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 219, "y" : 303 } } }, "connectors" : [ { "edgeId" : 80230, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 222, "y" : 313 }, "to" : { "x" : 233, "y" : 313 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 237, "y" : 313 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 237, "y" : 313 } } } ] }, { "id" : 80237, "reactomeId" : 10858248, "displayName" : "holoTF", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1478, "y" : 130 }, "minX" : 1455, "maxX" : 1508, "minY" : 113, "maxY" : 141, "prop" : { "x" : 1455, "y" : 119, "width" : 47, "height" : 22 }, "textPosition" : { "x" : 1457, "y" : 106 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1502, "y" : 119 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1502, "y" : 119 } } }, "connectors" : [ { "edgeId" : 80235, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80236, "reactomeId" : 10855878, "displayName" : "Homologues of apoTF", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1527, "y" : 11 }, "minX" : 1476, "maxX" : 1550, "minY" : 0, "maxY" : 60, "prop" : { "x" : 1505, "y" : 0, "width" : 45, "height" : 22 }, "textPosition" : { "x" : 1505, "y" : -27 }, "connectors" : [ { "edgeId" : 80235, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1515, "y" : 25 }, "to" : { "x" : 1476, "y" : 60 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80239, "reactomeId" : 9707310, "displayName" : "Hemes", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 37, "y" : 1154 }, "minX" : 11, "maxX" : 64, "minY" : 1138, "maxY" : 1171, "prop" : { "x" : 11, "y" : 1138, "width" : 53, "height" : 33 }, "textPosition" : { "x" : 12, "y" : 1144 }, "connectors" : [ { "edgeId" : 80238, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80241, "reactomeId" : 10843488, "displayName" : "Homologues of SLC46A1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 108, "y" : 1204 }, "minX" : 78, "maxX" : 139, "minY" : 1162, "maxY" : 1215, "prop" : { "x" : 78, "y" : 1193, "width" : 61, "height" : 22 }, "textPosition" : { "x" : 79, "y" : 1173 }, "connectors" : [ { "edgeId" : 80238, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 108, "y" : 1190 }, "to" : { "x" : 108, "y" : 1170 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 108, "y" : 1166 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 108, "y" : 1166 } } } ] }, { "id" : 80240, "reactomeId" : 9707308, "displayName" : "Hemes", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 190, "y" : 1154 }, "minX" : 165, "maxX" : 216, "minY" : 1138, "maxY" : 1171, "prop" : { "x" : 165, "y" : 1138, "width" : 51, "height" : 33 }, "textPosition" : { "x" : 165, "y" : 1144 }, "connectors" : [ { "edgeId" : 80238, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80243, "reactomeId" : 71185, "displayName" : "ferroheme", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 293, "y" : 737 }, "minX" : 105, "maxX" : 319, "minY" : 721, "maxY" : 835, "prop" : { "x" : 269, "y" : 722, "width" : 49, "height" : 30 }, "textPosition" : { "x" : 270, "y" : 720 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 313, "y" : 727 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 313, "y" : 727 } } }, "connectors" : [ { "edgeId" : 80242, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 80246, "type" : "INPUT", "segments" : [ { "from" : { "x" : 266, "y" : 749 }, "to" : { "x" : 105, "y" : 835 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80245, "reactomeId" : 10858255, "displayName" : "HisT", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 105, "y" : 940 }, "minX" : 71, "maxX" : 145, "minY" : 923, "maxY" : 979, "prop" : { "x" : 71, "y" : 929, "width" : 68, "height" : 22 }, "textPosition" : { "x" : 88, "y" : 929 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 139, "y" : 929 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 139, "y" : 929 } } }, "connectors" : [ { "edgeId" : 80242, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 105, "y" : 954 }, "to" : { "x" : 105, "y" : 971 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 105, "y" : 975 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 105, "y" : 975 } } } ] }, { "id" : 80244, "reactomeId" : 917877, "displayName" : "heme", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 24, "y" : 853 }, "minX" : 0, "maxX" : 107, "minY" : 835, "maxY" : 868, "prop" : { "x" : 0, "y" : 838, "width" : 49, "height" : 30 }, "textPosition" : { "x" : 3, "y" : 842 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 44, "y" : 843 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 44, "y" : 843 } } }, "connectors" : [ { "edgeId" : 80242, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 80246, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 52, "y" : 847 }, "to" : { "x" : 107, "y" : 835 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 58, "y" : 842 }, "b" : { "x" : 52, "y" : 847 }, "c" : { "x" : 60, "y" : 849 }, "type" : "ARROW", "centre" : { "x" : 60, "y" : 849 } } } ] }, { "id" : 80247, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 196, "y" : 747 }, "minX" : 105, "maxX" : 217, "minY" : 731, "maxY" : 835, "prop" : { "x" : 176, "y" : 732, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 180, "y" : 736 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 211, "y" : 737 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 211, "y" : 737 } } }, "connectors" : [ { "edgeId" : 80246, "type" : "INPUT", "segments" : [ { "from" : { "x" : 180, "y" : 765 }, "to" : { "x" : 105, "y" : 835 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80249, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 190, "y" : 910 }, "minX" : 107, "maxX" : 211, "minY" : 835, "maxY" : 926, "prop" : { "x" : 171, "y" : 895, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 174, "y" : 900 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 205, "y" : 900 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 205, "y" : 900 } } }, "connectors" : [ { "edgeId" : 80246, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 172, "y" : 892 }, "to" : { "x" : 107, "y" : 835 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 164, "y" : 890 }, "b" : { "x" : 172, "y" : 892 }, "c" : { "x" : 169, "y" : 884 }, "type" : "ARROW", "centre" : { "x" : 169, "y" : 884 } } } ] }, { "id" : 80248, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 252, "y" : 785 }, "minX" : 105, "maxX" : 275, "minY" : 769, "maxY" : 835, "prop" : { "x" : 231, "y" : 770, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 235, "y" : 774 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 269, "y" : 775 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 269, "y" : 775 } } }, "connectors" : [ { "edgeId" : 80246, "type" : "INPUT", "segments" : [ { "from" : { "x" : 228, "y" : 792 }, "to" : { "x" : 105, "y" : 835 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 80251, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 231, "y" : 837 }, "minX" : 107, "maxX" : 250, "minY" : 821, "maxY" : 852, "prop" : { "x" : 213, "y" : 822, "width" : 36, "height" : 30 }, "textPosition" : { "x" : 217, "y" : 826 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 244, "y" : 827 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 244, "y" : 827 } } }, "connectors" : [ { "edgeId" : 80246, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 210, "y" : 836 }, "to" : { "x" : 107, "y" : 835 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 203, "y" : 840 }, "b" : { "x" : 210, "y" : 836 }, "c" : { "x" : 203, "y" : 832 }, "type" : "ARROW", "centre" : { "x" : 203, "y" : 832 } } } ], "trivial" : true }, { "id" : 80250, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 230, "y" : 876 }, "minX" : 107, "maxX" : 245, "minY" : 835, "maxY" : 891, "prop" : { "x" : 217, "y" : 861, "width" : 27, "height" : 30 }, "textPosition" : { "x" : 221, "y" : 865 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 239, "y" : 866 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 239, "y" : 866 } } }, "connectors" : [ { "edgeId" : 80246, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 214, "y" : 871 }, "to" : { "x" : 107, "y" : 835 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 206, "y" : 873 }, "b" : { "x" : 214, "y" : 871 }, "c" : { "x" : 209, "y" : 865 }, "type" : "ARROW", "centre" : { "x" : 209, "y" : 865 } } } ] }, { "id" : 80252, "reactomeId" : 10858276, "displayName" : "ABCG2 tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 104, "y" : 742 }, "minX" : 67, "maxX" : 147, "minY" : 717, "maxY" : 827, "prop" : { "x" : 67, "y" : 723, "width" : 74, "height" : 39 }, "textPosition" : { "x" : 72, "y" : 727 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 141, "y" : 723 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 141, "y" : 723 } } }, "connectors" : [ { "edgeId" : 80246, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 104, "y" : 765 }, "to" : { "x" : 106, "y" : 819 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 106, "y" : 823 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 106, "y" : 823 } } } ] }, { "id" : 80255, "reactomeId" : 10833771, "displayName" : "V-ATPase", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1109, "y" : 772 }, "minX" : 959, "maxX" : 1149, "minY" : 718, "maxY" : 783, "prop" : { "x" : 1076, "y" : 761, "width" : 67, "height" : 22 }, "textPosition" : { "x" : 1076, "y" : 762 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1143, "y" : 761 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1143, "y" : 761 } } }, "connectors" : [ { "edgeId" : 80253, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1078, "y" : 758 }, "to" : { "x" : 959, "y" : 718 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 80254, "reactomeId" : 10833776, "displayName" : "VhaAC45", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1010, "y" : 774 }, "minX" : 959, "maxX" : 1048, "minY" : 718, "maxY" : 785, "prop" : { "x" : 979, "y" : 763, "width" : 63, "height" : 22 }, "textPosition" : { "x" : 982, "y" : 757 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1042, "y" : 763 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1042, "y" : 763 } } }, "connectors" : [ { "edgeId" : 80253, "type" : "INPUT", "segments" : [ { "from" : { "x" : 999, "y" : 760 }, "to" : { "x" : 959, "y" : 718 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 80225, "reactomeId" : 10858241, "displayName" : "CYBRD1:Heme reduces Fe3+ to Fe2+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 317, "y" : 113 }, "minX" : 298, "maxX" : 323, "minY" : 87, "maxY" : 178, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 317, "y" : 87 }, "to" : { "x" : 317, "y" : 113 } }, { "from" : { "x" : 317, "y" : 113 }, "to" : { "x" : 298, "y" : 178 } } ], "endShape" : { "a" : { "x" : 296, "y" : 170 }, "b" : { "x" : 298, "y" : 178 }, "c" : { "x" : 304, "y" : 172 }, "type" : "ARROW", "centre" : { "x" : 304, "y" : 172 } }, "reactionShape" : { "a" : { "x" : 311, "y" : 107 }, "b" : { "x" : 323, "y" : 119 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 317, "y" : 113 } }, "inputs" : [ { "id" : 80226, "points" : [ { "x" : 891, "y" : 168 }, { "x" : 857, "y" : 93 } ] }, { "id" : 80227, "points" : [ { "x" : 305, "y" : 65 } ] } ], "outputs" : [ { "id" : 80228 } ], "catalysts" : [ { "id" : 80229, "points" : [ { "x" : 110, "y" : 299 }, { "x" : 255, "y" : 112 } ] } ] }, { "id" : 80257, "reactomeId" : 10858243, "displayName" : "Acidification of Tf:TfR1 containing endosome", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 822, "y" : 860 }, "minX" : 736, "maxX" : 858, "minY" : 854, "maxY" : 866, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 858, "y" : 860 }, "to" : { "x" : 822, "y" : 860 } }, { "from" : { "x" : 822, "y" : 860 }, "to" : { "x" : 736, "y" : 860 } } ], "reactionShape" : { "a" : { "x" : 816, "y" : 854 }, "b" : { "x" : 828, "y" : 866 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 822, "y" : 860 } }, "inputs" : [ { "id" : 80258, "points" : [ { "x" : 900, "y" : 846 } ] }, { "id" : 80259, "points" : [ { "x" : 874, "y" : 832 } ] }, { "id" : 80260, "points" : [ { "x" : 892, "y" : 876 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 80261, "points" : [ { "x" : 731, "y" : 740 } ], "stoichiometry" : 3 }, { "id" : 80262, "points" : [ { "x" : 694, "y" : 842 } ] }, { "id" : 80263, "points" : [ { "x" : 696, "y" : 875 } ] } ], "catalysts" : [ { "id" : 80256, "points" : [ { "x" : 822, "y" : 783 } ] } ] }, { "id" : 80291, "reactomeId" : 10883621, "displayName" : "CANDI binds CUL1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 359, "y" : 1065 }, "minX" : 314, "maxX" : 365, "minY" : 1059, "maxY" : 1071, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 358, "y" : 1064 }, "to" : { "x" : 359, "y" : 1065 } }, { "from" : { "x" : 359, "y" : 1065 }, "to" : { "x" : 314, "y" : 1065 } } ], "endShape" : { "a" : { "x" : 321, "y" : 1061 }, "b" : { "x" : 314, "y" : 1065 }, "c" : { "x" : 321, "y" : 1069 }, "type" : "ARROW", "centre" : { "x" : 321, "y" : 1069 } }, "reactionShape" : { "c" : { "x" : 359, "y" : 1065 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 359, "y" : 1065 } }, "inputs" : [ { "id" : 80292, "points" : [ { "x" : 394, "y" : 1085 } ] }, { "id" : 80293, "points" : [ { "x" : 391, "y" : 1041 } ] } ], "outputs" : [ { "id" : 80294 } ] }, { "id" : 80295, "reactomeId" : 10883612, "displayName" : "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 813, "y" : 1034 }, "minX" : 770, "maxX" : 845, "minY" : 1028, "maxY" : 1040, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 845, "y" : 1034 }, "to" : { "x" : 813, "y" : 1034 } }, { "from" : { "x" : 813, "y" : 1034 }, "to" : { "x" : 770, "y" : 1034 } } ], "endShape" : { "a" : { "x" : 777, "y" : 1030 }, "b" : { "x" : 770, "y" : 1034 }, "c" : { "x" : 777, "y" : 1038 }, "type" : "ARROW", "centre" : { "x" : 777, "y" : 1038 } }, "reactionShape" : { "a" : { "x" : 807, "y" : 1028 }, "b" : { "x" : 819, "y" : 1040 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 813, "y" : 1034 } }, "inputs" : [ { "id" : 80296, "points" : [ { "x" : 859, "y" : 998 } ], "stoichiometry" : 3 }, { "id" : 80297, "points" : [ { "x" : 877, "y" : 1034 } ] } ], "outputs" : [ { "id" : 80298 } ], "catalysts" : [ { "id" : 80299, "points" : [ { "x" : 812, "y" : 1081 } ] } ] }, { "id" : 80230, "reactomeId" : 10853125, "displayName" : "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 249, "y" : 313 }, "minX" : 243, "maxX" : 255, "minY" : 263, "maxY" : 355, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 249, "y" : 263 }, "to" : { "x" : 249, "y" : 313 } }, { "from" : { "x" : 249, "y" : 313 }, "to" : { "x" : 249, "y" : 355 } } ], "reactionShape" : { "a" : { "x" : 243, "y" : 307 }, "b" : { "x" : 255, "y" : 319 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 249, "y" : 313 } }, "inputs" : [ { "id" : 80231, "points" : [ { "x" : 244, "y" : 231 } ] }, { "id" : 80228, "points" : [ { "x" : 284, "y" : 214 } ] } ], "outputs" : [ { "id" : 80232, "points" : [ { "x" : 284, "y" : 405 } ] }, { "id" : 80233, "points" : [ { "x" : 223, "y" : 403 } ] } ], "catalysts" : [ { "id" : 80234, "points" : [ { "x" : 222, "y" : 313 } ] } ] }, { "id" : 80264, "reactomeId" : 10858266, "displayName" : "MCOLN1 transports Fe2+ from endosome lumen to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 614, "y" : 616 }, "minX" : 313, "maxX" : 1051, "minY" : 441, "maxY" : 622, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1051, "y" : 614 }, "to" : { "x" : 614, "y" : 616 } }, { "from" : { "x" : 614, "y" : 616 }, "to" : { "x" : 480, "y" : 569 } }, { "from" : { "x" : 480, "y" : 569 }, "to" : { "x" : 313, "y" : 441 } } ], "endShape" : { "a" : { "x" : 321, "y" : 442 }, "b" : { "x" : 313, "y" : 441 }, "c" : { "x" : 316, "y" : 448 }, "type" : "ARROW", "centre" : { "x" : 316, "y" : 448 } }, "reactionShape" : { "a" : { "x" : 608, "y" : 610 }, "b" : { "x" : 620, "y" : 622 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 614, "y" : 616 } }, "inputs" : [ { "id" : 80265 } ], "outputs" : [ { "id" : 80232 } ], "catalysts" : [ { "id" : 80266, "points" : [ { "x" : 614, "y" : 652 } ] } ] }, { "id" : 80235, "reactomeId" : 10858250, "displayName" : "apoTF binds 2Fe3+ to form holoTF", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1477, "y" : 59 }, "minX" : 1471, "maxX" : 1483, "minY" : 53, "maxY" : 116, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1476, "y" : 60 }, "to" : { "x" : 1477, "y" : 59 } }, { "from" : { "x" : 1477, "y" : 59 }, "to" : { "x" : 1477, "y" : 116 } } ], "endShape" : { "a" : { "x" : 1473, "y" : 109 }, "b" : { "x" : 1477, "y" : 116 }, "c" : { "x" : 1481, "y" : 109 }, "type" : "ARROW", "centre" : { "x" : 1481, "y" : 109 } }, "reactionShape" : { "c" : { "x" : 1477, "y" : 59 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1477, "y" : 59 } }, "inputs" : [ { "id" : 80236, "points" : [ { "x" : 1515, "y" : 25 } ] }, { "id" : 80226, "points" : [ { "x" : 925, "y" : 180 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 80237 } ] }, { "id" : 80267, "reactomeId" : 10862903, "displayName" : "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 568, "y" : 469 }, "minX" : 502, "maxX" : 655, "minY" : 463, "maxY" : 475, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 502, "y" : 469 }, "to" : { "x" : 568, "y" : 469 } }, { "from" : { "x" : 568, "y" : 469 }, "to" : { "x" : 655, "y" : 469 } } ], "endShape" : { "a" : { "x" : 648, "y" : 473 }, "b" : { "x" : 655, "y" : 469 }, "c" : { "x" : 648, "y" : 465 }, "type" : "ARROW", "centre" : { "x" : 648, "y" : 465 } }, "reactionShape" : { "a" : { "x" : 562, "y" : 463 }, "b" : { "x" : 574, "y" : 475 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 568, "y" : 469 } }, "inputs" : [ { "id" : 80232, "points" : [ { "x" : 321, "y" : 428 } ], "stoichiometry" : 4 }, { "id" : 80268, "points" : [ { "x" : 484, "y" : 438 } ], "stoichiometry" : 4 }, { "id" : 80269, "points" : [ { "x" : 488, "y" : 489 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 80270, "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 80271, "points" : [ { "x" : 568, "y" : 428 } ] } ] }, { "id" : 80238, "reactomeId" : 10858246, "displayName" : "SLC46A1 transports hemes from extracellular region to cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 108, "y" : 1154 }, "minX" : 70, "maxX" : 159, "minY" : 1148, "maxY" : 1160, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 70, "y" : 1154 }, "to" : { "x" : 108, "y" : 1154 } }, { "from" : { "x" : 108, "y" : 1154 }, "to" : { "x" : 159, "y" : 1154 } } ], "endShape" : { "a" : { "x" : 152, "y" : 1158 }, "b" : { "x" : 159, "y" : 1154 }, "c" : { "x" : 152, "y" : 1150 }, "type" : "ARROW", "centre" : { "x" : 152, "y" : 1150 } }, "reactionShape" : { "a" : { "x" : 102, "y" : 1148 }, "b" : { "x" : 114, "y" : 1160 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 108, "y" : 1154 } }, "inputs" : [ { "id" : 80239 } ], "outputs" : [ { "id" : 80240 } ], "catalysts" : [ { "id" : 80241, "points" : [ { "x" : 108, "y" : 1190 } ] } ] }, { "id" : 80272, "reactomeId" : 10876651, "displayName" : "LCN2:2,5DHBA binds Fe3+", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 972, "y" : 218 }, "minX" : 966, "maxX" : 1010, "minY" : 212, "maxY" : 224, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 973, "y" : 216 }, "to" : { "x" : 972, "y" : 218 } }, { "from" : { "x" : 972, "y" : 218 }, "to" : { "x" : 1010, "y" : 216 } } ], "endShape" : { "a" : { "x" : 1003, "y" : 220 }, "b" : { "x" : 1010, "y" : 216 }, "c" : { "x" : 1003, "y" : 212 }, "type" : "ARROW", "centre" : { "x" : 1003, "y" : 212 } }, "reactionShape" : { "c" : { "x" : 972, "y" : 218 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 972, "y" : 218 } }, "inputs" : [ { "id" : 80273, "points" : [ { "x" : 958, "y" : 238 } ] }, { "id" : 80226, "points" : [ { "x" : 925, "y" : 195 } ] } ], "outputs" : [ { "id" : 80274 } ] }, { "id" : 80275, "reactomeId" : 10881015, "displayName" : "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1132, "y" : 375 }, "minX" : 1126, "maxX" : 1206, "minY" : 336, "maxY" : 381, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1129, "y" : 336 }, "to" : { "x" : 1132, "y" : 375 } }, { "from" : { "x" : 1132, "y" : 375 }, "to" : { "x" : 1206, "y" : 375 } } ], "reactionShape" : { "a" : { "x" : 1126, "y" : 369 }, "b" : { "x" : 1138, "y" : 381 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1132, "y" : 375 } }, "inputs" : [ { "id" : 80276 } ], "outputs" : [ { "id" : 80277, "points" : [ { "x" : 1258, "y" : 333 } ] }, { "id" : 80278, "points" : [ { "x" : 1242, "y" : 397 } ] } ], "catalysts" : [ { "id" : 80279, "points" : [ { "x" : 1022, "y" : 324 }, { "x" : 1069, "y" : 375 } ] } ] }, { "id" : 80242, "reactomeId" : 10858258, "displayName" : "FLVCR1-1 transports heme from cytosol to extracellular region", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 105, "y" : 987 }, "minX" : 23, "maxX" : 292, "minY" : 755, "maxY" : 993, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 292, "y" : 755 }, "to" : { "x" : 292, "y" : 987 } }, { "from" : { "x" : 292, "y" : 987 }, "to" : { "x" : 105, "y" : 987 } }, { "from" : { "x" : 105, "y" : 987 }, "to" : { "x" : 23, "y" : 987 } }, { "from" : { "x" : 23, "y" : 987 }, "to" : { "x" : 23, "y" : 871 } } ], "endShape" : { "a" : { "x" : 27, "y" : 878 }, "b" : { "x" : 23, "y" : 871 }, "c" : { "x" : 19, "y" : 878 }, "type" : "ARROW", "centre" : { "x" : 19, "y" : 878 } }, "reactionShape" : { "a" : { "x" : 99, "y" : 981 }, "b" : { "x" : 111, "y" : 993 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 105, "y" : 987 } }, "inputs" : [ { "id" : 80243 } ], "outputs" : [ { "id" : 80244 } ], "catalysts" : [ { "id" : 80245, "points" : [ { "x" : 105, "y" : 954 } ] } ] }, { "id" : 80246, "reactomeId" : 10858279, "displayName" : "ABCG2 tetramer transports heme from cytosol to extracellular region", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 106, "y" : 835 }, "minX" : 99, "maxX" : 111, "minY" : 829, "maxY" : 841, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 105, "y" : 835 }, "to" : { "x" : 106, "y" : 835 } }, { "from" : { "x" : 106, "y" : 835 }, "to" : { "x" : 107, "y" : 835 } } ], "reactionShape" : { "a" : { "x" : 100, "y" : 829 }, "b" : { "x" : 112, "y" : 841 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 106, "y" : 835 } }, "inputs" : [ { "id" : 80247, "points" : [ { "x" : 180, "y" : 765 } ] }, { "id" : 80248, "points" : [ { "x" : 228, "y" : 792 } ] }, { "id" : 80243, "points" : [ { "x" : 266, "y" : 749 } ] } ], "outputs" : [ { "id" : 80244, "points" : [ { "x" : 52, "y" : 847 } ] }, { "id" : 80249, "points" : [ { "x" : 172, "y" : 892 } ] }, { "id" : 80250, "points" : [ { "x" : 214, "y" : 871 } ] }, { "id" : 80251, "points" : [ { "x" : 210, "y" : 836 } ] } ], "catalysts" : [ { "id" : 80252, "points" : [ { "x" : 104, "y" : 765 } ] } ] }, { "id" : 80280, "reactomeId" : 10883595, "displayName" : "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1539, "y" : 1070 }, "minX" : 1497, "maxX" : 1623, "minY" : 1064, "maxY" : 1076, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1497, "y" : 1070 }, "to" : { "x" : 1539, "y" : 1070 } }, { "from" : { "x" : 1539, "y" : 1070 }, "to" : { "x" : 1623, "y" : 1070 } } ], "endShape" : { "a" : { "x" : 1616, "y" : 1074 }, "b" : { "x" : 1623, "y" : 1070 }, "c" : { "x" : 1616, "y" : 1066 }, "type" : "ARROW", "centre" : { "x" : 1616, "y" : 1066 } }, "reactionShape" : { "a" : { "x" : 1533, "y" : 1064 }, "b" : { "x" : 1545, "y" : 1076 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1539, "y" : 1070 } }, "inputs" : [ { "id" : 80281, "points" : [ { "x" : 1435, "y" : 1030 } ], "stoichiometry" : 4 }, { "id" : 80282, "points" : [ { "x" : 1430, "y" : 1060 } ], "stoichiometry" : 4 }, { "id" : 80283, "points" : [ { "x" : 1431, "y" : 1092 } ], "stoichiometry" : 4 } ], "outputs" : [ { "id" : 80284, "stoichiometry" : 4 } ], "catalysts" : [ { "id" : 80285, "points" : [ { "x" : 1539, "y" : 1033 } ] } ] }, { "id" : 80253, "reactomeId" : 10876987, "displayName" : "ATP6AP1 binds V-ATPase", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 905, "y" : 736 }, "minX" : 852, "maxX" : 965, "minY" : 712, "maxY" : 755, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 959, "y" : 718 }, "to" : { "x" : 905, "y" : 736 } }, { "from" : { "x" : 905, "y" : 736 }, "to" : { "x" : 852, "y" : 755 } } ], "endShape" : { "a" : { "x" : 857, "y" : 749 }, "b" : { "x" : 852, "y" : 755 }, "c" : { "x" : 860, "y" : 756 }, "type" : "ARROW", "centre" : { "x" : 860, "y" : 756 } }, "reactionShape" : { "c" : { "x" : 905, "y" : 736 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 905, "y" : 736 } }, "inputs" : [ { "id" : 80254, "points" : [ { "x" : 999, "y" : 760 } ] }, { "id" : 80255, "points" : [ { "x" : 1078, "y" : 758 } ] } ], "outputs" : [ { "id" : 80256 } ] }, { "id" : 80286, "reactomeId" : 10883478, "displayName" : "ACO1 binds 4Fe-4S", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1024, "y" : 1002 }, "minX" : 1018, "maxX" : 1067, "minY" : 996, "maxY" : 1008, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1023, "y" : 1002 }, "to" : { "x" : 1024, "y" : 1002 } }, { "from" : { "x" : 1024, "y" : 1002 }, "to" : { "x" : 1067, "y" : 1002 } } ], "endShape" : { "a" : { "x" : 1060, "y" : 1006 }, "b" : { "x" : 1067, "y" : 1002 }, "c" : { "x" : 1060, "y" : 998 }, "type" : "ARROW", "centre" : { "x" : 1060, "y" : 998 } }, "reactionShape" : { "a" : { "x" : 1018, "y" : 996 }, "b" : { "x" : 1030, "y" : 1008 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1024, "y" : 1002 } }, "inputs" : [ { "id" : 80287, "points" : [ { "x" : 994, "y" : 1021 } ] }, { "id" : 80288, "points" : [ { "x" : 994, "y" : 972 } ] } ], "outputs" : [ { "id" : 80289 } ], "catalysts" : [ { "id" : 80287, "points" : [ { "x" : 979, "y" : 1021 }, { "x" : 979, "y" : 1002 } ] } ], "activators" : [ { "id" : 80290, "points" : [ { "x" : 1149, "y" : 1073 } ] } ] } ], "compartments" : [ { "id" : 80320, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 438, "y" : 635 }, "minX" : 372, "maxX" : 504, "minY" : 596, "maxY" : 675, "prop" : { "x" : 372, "y" : 596, "width" : 132, "height" : 79 }, "textPosition" : { "x" : 382, "y" : 612 }, "insets" : { "x" : 382, "y" : 606, "width" : 112, "height" : 59 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 80301, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1554, "y" : 1054 }, "minX" : 1365, "maxX" : 1743, "minY" : 976, "maxY" : 1132, "prop" : { "x" : 1365, "y" : 976, "width" : 378, "height" : 156 }, "textPosition" : { "x" : 1440, "y" : 1084 }, "insets" : { "x" : 1375, "y" : 986, "width" : 358, "height" : 136 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 80281, 80285, 80284, 80280, 80282, 80283 ] }, { "id" : 80300, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 950, "y" : 817 }, "minX" : 100, "maxX" : 1800, "minY" : 308, "maxY" : 1327, "prop" : { "x" : 100, "y" : 308, "width" : 1700, "height" : 1019 }, "textPosition" : { "x" : 120, "y" : 332 }, "insets" : { "x" : 110, "y" : 318, "width" : 1680, "height" : 999 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 80302, 80303, 80234, 80232, 80233, 80230, 80241, 80238, 80243, 80242, 80247, 80248, 80252, 80250, 80257, 80258, 80260, 80263, 80259, 80262, 80267, 80270, 80271, 80268, 80269, 80279, 80276, 80275, 80277, 80288, 80289, 80286, 80287, 80315, 80325, 80291, 80294, 80292, 80293, 80299, 80295, 80296, 80297, 80326, 80298, 80229, 80278, 80245, 80240, 80320, 80290, 80321, 80327, 80246, 80251, 80249 ] }, { "id" : 80303, "reactomeId" : 171907, "displayName" : "endosome lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 994, "y" : 647 }, "minX" : 609, "maxX" : 1379, "minY" : 518, "maxY" : 777, "prop" : { "x" : 609, "y" : 518, "width" : 770, "height" : 259 }, "textPosition" : { "x" : 928, "y" : 649 }, "insets" : { "x" : 619, "y" : 528, "width" : 750, "height" : 239 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 80265, 80264, 80266, 80254, 80255, 80256, 80261, 80253 ] }, { "id" : 80302, "reactomeId" : 17927, "displayName" : "mitochondrial intermembrane space", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1546, "y" : 1063 }, "minX" : 1322, "maxX" : 1771, "minY" : 958, "maxY" : 1169, "prop" : { "x" : 1322, "y" : 958, "width" : 449, "height" : 211 }, "textPosition" : { "x" : 1380, "y" : 1123 }, "insets" : { "x" : 1332, "y" : 968, "width" : 429, "height" : 191 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 80301 ] } ], "notes" : [ ], "links" : [ { "id" : 80325, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 976, "y" : 1076 }, "minX" : 970, "maxX" : 982, "minY" : 1049, "maxY" : 1104, "segments" : [ { "from" : { "x" : 979, "y" : 1049 }, "to" : { "x" : 974, "y" : 1104 } } ], "reactionShape" : { "a" : { "x" : 970, "y" : 1070 }, "b" : { "x" : 982, "y" : 1082 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 976, "y" : 1076 } }, "inputs" : [ { "id" : 80287 } ], "outputs" : [ { "id" : 80315 } ] }, { "id" : 80327, "renderableClass" : "Interaction", "position" : { "x" : 1178, "y" : 1001 }, "minX" : 1161, "maxX" : 1195, "minY" : 995, "maxY" : 1007, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1161, "y" : 1001 }, "to" : { "x" : 1195, "y" : 1001 } } ], "endShape" : { "a" : { "x" : 1188, "y" : 1005 }, "b" : { "x" : 1195, "y" : 1001 }, "c" : { "x" : 1188, "y" : 997 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1188, "y" : 997 } }, "reactionShape" : { "a" : { "x" : 1172, "y" : 995 }, "b" : { "x" : 1184, "y" : 1007 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1178, "y" : 1001 } }, "inputs" : [ { "id" : 80289 } ], "outputs" : [ { "id" : 80321 } ] }, { "id" : 80326, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 937, "y" : 1076 }, "minX" : 910, "maxX" : 964, "minY" : 1048, "maxY" : 1104, "segments" : [ { "from" : { "x" : 910, "y" : 1048 }, "to" : { "x" : 964, "y" : 1104 } } ], "reactionShape" : { "a" : { "x" : 931, "y" : 1070 }, "b" : { "x" : 943, "y" : 1082 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 937, "y" : 1076 } }, "inputs" : [ { "id" : 80297 } ], "outputs" : [ { "id" : 80315 } ] } ], "shadows" : [ { "id" : 80328, "reactomeId" : 10912192, "displayName" : "Transferrin endocytosis and recycling", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 706, "y" : 654 }, "minX" : 260, "maxX" : 1153, "minY" : 398, "maxY" : 910, "prop" : { "x" : 260, "y" : 398, "width" : 893, "height" : 512 }, "points" : [ { "x" : 260, "y" : 398 }, { "x" : 1153, "y" : 398 }, { "x" : 1153, "y" : 910 }, { "x" : 260, "y" : 910 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 1800, "minY" : 0, "maxY" : 1327, "disease" : false }